Paul K. Crane, MD, MPH

RESEARCH

Current

1. 1U01HG006375-01       Larson (PI)
   NIH/NHGRI       08/15/11-07/31/15
   Development and use of network infrastructure for high-throughput GWA studies
   This project will continue the efforts of the Group Health/University of Washington eMERGE collaboration to expand the library of phenotypes derived from electronic medical records; advance the integration of genome-scale data into clinical practice; and broaden the impact of eMERGE through new collaborations.
   Role: Co-Investigator.

2. U01 AG006781       Larson (PI)
   National Institute on Aging       09/15/09-08/31/14
   Alzheimer's Disease Patient Registry (ADPR)
   The Adult Changes of Thought (ACT) study's goals are to advance understanding of factors associated with late life brain outcomes of dementia, cognitive decline, and fixed and frozen findings at autopsy. (Wrote the majority of the grant application.)
   Role: PI of UW subcontract.

3. 2U01 AG006781       Larson (PI)       03/01/12-08/31/14
   Longitudinal Effect of Anticholinergic Polypharmacy on Dementia and Neuropathology
   Role: Co-investigator. (funded Supplement)

4. U01 AR 057954       H. Crane, P. Crane, and D. Patrick (multiple PIs)
   National Institute of Arthritis and Musculoskeletal & Skin Diseaseses       09/30/09-07/31/13
   Patient reported outcomes in routine clinical care of patients infected with HIV
   The goals of this project are to evaluate the validity of Patient Reported Outcome (PRO) Measurement Information System (PROMIS) scales for patients with HIV, and to integrate PRO assessment into routine clinical care. (Wrote the majority of the grant application.)
   Role: One of 3 Principal Investigators. Annual direct costs to subcontract: $710,097.
   

5. R01 AG010220       Mungas (PI)
   National Institute on Aging       08/15/08-05/31/13
   English and Spanish assessment of cognition in elderly
   The goals of this project are to further develop and establish the validity of the Spanish and English Neuropsychological Assessment Scales (SENAS).
   Role: Co-Investigator.

6. R01 AG 029672       P. Crane (PI)
   National Institute on Aging       09/15/07-08/31/12
   Improving cognitive outcome precision & responsiveness with modern psychometrics
   The goals of this project are to identify optimal ways of scoring neuropsychological test data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Subcortical Ischemic Vascular Dementia Program Project Grant (SIVD PPG) using tools of modern psychometrics. (Wrote the majority of the grant application.)
   Role: Principal Investigator

7. R01 AG030618       Marcantonio (PI)
   National Institute on Aging       09/01/08-6/30/12
   3D-CAM: Deriving and Validating a 3-minute Diagnostic Assessment for Delirium
   The goal of this project is to develop and validate a 3 minute tool for identifying delirium in hospitalized and institutionalized individuals.
   Role: Co-Investigator.

8. U01 AG 032984       Schellenberg (PI)
   National Institutes of Health       04/01/11-03/31/12
   Genetics of robustness: psychometrically sophisticated GWAS of cognitive decline in AD
   The goals of this project are identifying SNPs associated with faster or slower rates of decline in cognitive functioning among AD cases.
   Role: Co-Investigator.

9. R01 AG 029672       P. Crane (PI)
   National Institute on Aging       09/15/07-08/31/12
   Improving cognitive outcome precision & responsiveness with modern psychometrics
   The goals of this project are to identify optimal ways of scoring neuropsychological test data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Subcortical Ischemic Vascular Dementia Program Project Grant (SIVD PPG) using tools of modern psychometrics. (Wrote the majority of the grant application.)
   Role: Principal Investigator

10. R01 AG030618       Marcantonio (PI)
    National Institute on Aging       09/01/08-6/30/12
    3D-CAM: Deriving and Validating a 3-minute Diagnostic Assessment for Delirium
    The goal of this project is to develop and validate a 3 minute tool for identifying delirium in hospitalized and institutionalized individuals.
    Role: Co-Investigator.

11. U01 AG 032984       Schellenberg (PI)
    National Institutes of Health       04/01/11-03/31/12
    Genetics of robustness: psychometrically sophisticated GWAS of cognitive decline in AD
    The goals of this project are identifying SNPs associated with faster or slower rates of decline in cognitive functioning among AD cases.
    Role: Co-investigator.

Pending

1. R01 AG 029672       P. Crane (PI)
   National Institute on Aging       9/1/2013-8/13/2018
   Improving cognitive outcome precision & responsiveness with modern psychometrics
   The goals of this project are to apply what we learned in the first cycle of this project to the new category of Early Mild Cognitive Impairment (EMCI); to use Bayesian approaches to improve our measurement; and to evaluate longitudinal relationships between brain structure, metabolism, and cognition. Role: PI.

2. R24 AHRQ       Katzan (PI)
   AHRQ       8/19/2013-8/18/2018
   Using Health IT with PROs to Improve Patient-Centered Care in Neurologic Disorders
   The goals of this project are to establish research infrastructure for evaluating patient-reported outcomes data collected at the point of care. Role: Co-investigator; PI of UW subcontract

Past

1. U01 HG004610       Larson (PI)
   National Human Genome Institute       09/27/07-09/29/11
   Development and use of network infrastructure for high-throughput GWA studies
   The goals of this project are to collaborate with partner sites in the Electronic Medical Records and Genomics (eMERGE) network to perform genome-wide association studies (GWAS) of several phenotypes identified from electronic medical records. (Wrote the majority of the grant application.)
   Role: Co-Investigator.

2. R01 AG 024180       Craft (PI)
   National Institute on Aging       04/01/06-03/31/11
   MCI, Insulin, and Cholesterol in a Community Sample
   The goals of this project are to identify and determine correlates of mild cognitive impairment (MCI) in the ACT cohort.
   Role: Co-Investigator.

3. 5 U01 AG006781       Larson (PI)
   National Institute on Aging       07/01/06-08/31/09
   Alzheimer's Disease Patient Registry (ADPR)
   Role: Co-Investigator.

4. 1 U01 AR052177       Cella (PI)
   National Institute of Arthritis and Musculoskeletal Diseases       09/28/04-07/31/09
   NIH PROMIS statistical coordinating center
   Role: Co-Investigator.

5. 5 R01 MH069864       Von Korff (PI)
   National Institute on Mental Health       01/01/04-12/31/07
   Social Role Disability and Mental-Physical Co-Morbidity
   Role: Co-Investigator.