|FDA Bans Ephedra|
By Ellen Kuwana |
Neuroscience for Kids Staff Writer
April 16, 2004
US FDA Bans the Herbal Supplement Ephedra
The Chinese call it ma-huang.
Natural Does NOT Equal Safe: The Effects on Your BodyThe active ingredient in ephedra is ephedrine, a natural chemical from a plant. Ephedrine is similar to adrenaline, the substance your body produces in a "fight-or-flight" crisis. These stimulants (such as amphetamines) excite your central nervous system, increase your heart rate, and raise your blood pressure. Adrenaline and ephedrine cause your blood to pump to your muscles, so that you could fight off an attacker, or run away from a predator. Imagine being really scared. Your heartbeat sounds loud. Your breathing is rapid. Your pupils are dilated. You are alert and ready to react. That is the effect of adrenaline...and ephedrine.
These effects, though, can stress your body to the point that it overheats (called heat stroke, when your core body temperature exceeds 104oF), sustains nerve damage, or, worse, triggers a stroke, heart attack, or even sudden death.
Ephedra Contributes to the Death of a Baseball PlayerEphedra was brought to the public's attention after 23-year-old Baltimore Orioles pitcher Steve Belcher died in February of 2003. After taking ephedra tablets for weight loss, he suffered a heat stroke during practice.
Researchers Conclude Ephedra is DangerousThe FDA commissioned an independent research organization, the RAND Corporation, to study ephedra and report any adverse effects. They concluded that ephedra caused a 2- to 3-fold increase in health problems such as depression, anxiety, insomnia, vomiting, heartburn and heartbeat irregularities. The researchers counted 15,951 cases in which a medical problem had been reported to the manufacturer either by a doctor or by the user. Of these, 283 were classified as "severe" and included 5 deaths, 11 strokes, 5 heart attacks and 4 seizures. Three states (California, New York and Illinois) and most major league sports teams have banned the use of ephedra. (Source: Science News, April 12, 2004.)
Burden of ProofWith prescription drugs, a manufacturer has to prove that medicine is safe and brings about the advertised effects. Supplements, however, do not fall under such strict laws. (Ephedrine, when manufactured in a lab, is regulated as a drug by the FDA!) Since 1994, the FDA has had to prove that a supplement is harmful; manufacturers do not have to prove that the supplement is safe and effective. Thus, the FDA does not have much power to regulate herbal products. It is up to the consumer to research what is safe. It is also important to tell your doctor what supplements you are taking, because though they may be "natural," they also may adversely interact with prescription drugs. (Remember, many poisons are "natural," too!)
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