Beagle is a software package that performs genotype calling, genotype phasing, imputation of ungenotyped markers, and identity-by-descent segment detection.
Beagle version 4.1 has a more accurate genotype phasing algorithm and a very fast and accurate genotype imputation algorithm.
Version 4.1 also has several changes to the command line arguments which are described in the release notes. The "ped" argument has no effect in version 4.1. If your data contains nuclear families and you want to model the parent-offspring relationships when phasing genotypes, please use version 4.0.
If you use Beagle in a published analysis, please report the program version and cite the article:
S R Browning and B L Browning (2007) Rapid and accurate haplotype phasing and missing data inference for whole genome association studies by use of localized haplotype clustering. Am J Hum Genet 81:1084-97. doi:10.1086/521987
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Beagle is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version.
Beagle is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.
You can download a copy of the the GNU General Public License using a link provided below. If not, see http://www.gnu.org/licenses/.
The Beagle 4.1 source code will be posted below as soon as the the paper describing its new methods is published.
|beagle.09Oct15.56b.jar||Beagle program file (requires Java version 8)|
|beagle_4.1_03Oct15.pdf||Beagle version 4.1 documentation|
|run.beagle.09Oct15.56b.example||a unix script which runs a short Beagle analysis|
|release_notes||description of new features in recent versions|
|gpl_license||GNU General Public License|
The following resources are also available:
|human genetic maps||HapMap GrCh36 and GrCh37 genetic maps in PLINK format for use with Refined IBD|
|human reference panel||1000 Genomes Project phase 3 reference panel.|
|conform-gt||a program for making alleles in a VCF file to be consistent with a reference VCF file.|
|bref.09Oct15.56b.jar||a program for compressing diploid reference VCF files. Enter "java -jar bref.jar" for program documentation.|
|Beagle Utilities||a suite of utility programs|
|version 4.0||the Beagle version 4.0 web page|
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Copyright: 2013-2015 Brian L. Browning
Last updated: 09 October 2015