Features of venous return curves

Mean circulatory pressure

Conceptually, pressure becomes uniform throughout the vasculature shortly after flow is reduced to zero. This pressure, Pmc, manifests the current total volume of blood within the vasculature in relation to the lumped compliance of the entire vasculature. Does the blood volume really distribute itself to a final equilibrium before reflex-driven changes, autoregulatory responses to pressure changes and, eventually, metabolic signals, radically alter the elastic state of the vasculature? Probably not. But, regardless of measurement practicality, Pmc is useful in our thinking about total blood volume in relationship to the instantaneous elastic state of the vasculature. However, regarding it as the pressure driving Qr is an absurdity that arises from a mathematical abstraction based on the linear sloped segment of venous return curves.

Linear sloped segment

The sloped portion of a venous return curve does look like the record of flow that would be obtained if flow were driven by the difference between Pmc (constant) and Pcv (variable). The size of the resistance across which this driving pressure acts would be computed as the negative reciprocal of the slope (details in Figure 3 legend).

Guyton and others adopted this interpretation in describing venous return as driven through a vascular resistance by the (Pmc - Pcv) gradient. The resistance was interpreted as corresponding physically to, or at least being dominated by, the resistance of the venous portion of the total peripheral resistance. (1, 9). In a paper that recognized that other parameters, including arterial resistance and capacitances of the system are combined in this apparent resistance, the term "venous impedance" was used (6). Perhaps this choice reinforced the idea that the slope revealed a venous system property. The term "impedance" readily generalizes to "resistance", since the data refer to steady-state conditions of flow in which the distinction between the two terms is irrelevant.

A system with venous return driven by the difference between Pmc and Pcv through a single hydraulic resistance, R, i.e., Qr equals (Pmc - Pcv) divided by R, would indeed show a negatively sloped relationship like the linear portion of venous return curves (Figure 3). But that does not mean that the linear sloped segment may be interpreted on the basis of the physical model in Figure 1, with Pmc as the pressure in the peripheral venous compartment that drives flow against the resistance of the venous system in proportion to the difference between Pmc and Pcv.

To see this, one needs to work out the mathematical details and describe the behavior of the physical model. Levy did this with a simple one resistance, two capacitance electrical equivalent (8), sufficient to show how the change in pressure profile caused by altered cardiac output would result in transfer of volume between two compliant compartments. But, recognizing that relatively little volume change occurs within the arterial compartment and that the differences between Qo and Qr are accommodated almost entirely through dynamic distribution of volume within the venous system, the model illustrated in Figure 4 is the simplest possible first approximation to physical properties of the peripheral vasculature. It is an electrical analog of the physical model illustrated in Figure 1, augmented by a hydraulic resistance and compliance representing the arterial system.

In this model, hydraulic resistances of the arterial and venous systems are modeled by electrical resistances and compliance of the arterial system and the two compartments of the venous system are modeled by capacitances. The analogous relationships are: electrical current as blood flow, electrical resistance as hydraulic resistance, voltage as pressure, and charge as volume. System "volume" is set by the initial condition of charge in the capacitors* see footnote. The model is driven by a pure current source, i.e. one which produces a set level of current independent of voltages at its terminals. This is a reasonable analogy to the kind of pump used in setting Qo in the experiments described above.

With zero flow, voltages equilibrate, i.e. Pa = Ppv = Pcv, at a level that depends upon the total charge (system volume) set as an initial condition. Charge distributes among the capacitances in proportion to their capacitance. This uniform voltage and distribution of charge is the analog of the zero-flow situation in which mean circulatory pressure, Pmc, is seen. When flow is forced through, the development of pressure gradients causes increased charge in the arterial capacitance, and reduced charge in the venous capacitances. Progressive increase in flow results in progressive decrease in Pcv.

Figure 5 shows that the behavior of this model resembles that observed in the linear sloped segment of venous return curves. Naturally, the flat segment of high and fixed Qr over a range of Pcv is not predicted, because this is the consequence of non-linear behavior of the elastic and resistive components of the vasculature, e.g., collapse and fluttering of vessels in which subatmospheric pressures develop. But, is the slope determined by the resistance of the venous system and is flow driven by (Pmc - Pvc)?

Indeed, the equations that describe the flow:pressure relationship of the circuit can be combined in the following form:

In the above equation, Q represents flow, and Req represents the following:

Similar expressions appear in papers by Guyton et al. that specifically addressed models of this general form, though with different placement of the capacitors (2, 6). Details of the derivation are in a separate document.

These show that the relationship between central venous pressure and flow can be expressed in a mathematical abstraction in which the venous return appears to driven by a pressure gradient across an equivalent resistance. However, the equivalent resistance does not correspond to an actual physical resistance in the model. Neither does Pmc exist as a pressure at a physical node in the model, except under the specific condition of zero flow.

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Footnote 1

* Capacitors do not accurately represent compliant vascular compartments because the latter contain volume at zero distending pressure, "rest" volume. However, rest volume can be ignored in modeling of system dynamics.

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