Understanding natural resistance to neurodegeneration

We are using quantitative genetics, proteomics, and metabolomics to identify genes and pathways that confer resistance to neurodegenerative diseases, with a particular focus on Alzheimer's Disease.

An atlas of cell-types for the fly brain

We are using massively parallel single-cell sequencing methods to map the diversity of neuronal cell-types found in the Drosophila central nervous system.

Origins of cell-type specific neurodegeneration

We are combining genetic manipulations with molecular physiology, electrophysiology, and behavior to understand why specific neuronal cell-types are susceptible or resistant to neurodegenerative diseases such as Alzheimer's.

Who we are