VC 2.00I 15-JUL-2003 02-AUG-2003 08:43:24 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\hx160c\tlk\hx160c.inp FNI: U:\archive\hx160c\tlk\hx160c.inp FNO: U:\archive\hx160c\tlk\hx160c.out RADX: U:\archive\hx160c\tlk\hx160c.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 4.762208E-03 (=0.476%) PHI2= 4.762208E-03 (=0.476%) (1-A1)*PHI1= 1.190552E-03 (=0.119%) (1-A2)*PHI2= 3.571656E-03 (=0.357%) (1-A1)*(1-PHI1)= 2.488094E-01 (=24.881%) (1-A2)*(1-PHI2)= 7.464283E-01 (=74.643%) RHT1= 0.143707 h (=8.62 minute) RHT2= 7.098896 h (=425.93 minute) LAM1= 4.8233305E+00 (1/h) LAM2= 9.7641542E-02 (1/h) BMR= 1.2292998E-03 (1/h) LAM1/BMR= 3.9236405E+03 LAM2/BMR= 7.9428584E+01 (LAM1+LAM2)/BMR= 4.0030691E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 3.5717E-02 + 3.5717E-02 = 7.1433123E-02 (1/Gy) beta: 4.7093E-02 + 1.7368E-01 = 2.2077590E-01 (1/Gy^2) alpha/beta: 0.3235549 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 5.208E-02 9.605E+01 1.000E-01 1.920E+00 9.295E-03 8.361E-05 9.3787E-03 9.906651E-01 3 1.302E-01 9.613E+01 2.500E-01 1.920E+00 3.084E-02 2.042E-04 3.1047E-02 9.694304E-01 4 2.604E-01 9.626E+01 5.000E-01 1.920E+00 8.503E-02 3.934E-04 8.5419E-02 9.181278E-01 5 5.208E-01 9.652E+01 1.000E+00 1.920E+00 2.525E-01 7.325E-04 2.5326E-01 7.762634E-01 6 7.812E-01 9.678E+01 1.500E+00 1.920E+00 4.874E-01 1.027E-03 4.8840E-01 6.136092E-01 7 1.042E+00 9.704E+01 2.000E+00 1.920E+00 7.800E-01 1.284E-03 7.8128E-01 4.578213E-01 8 1.562E+00 9.756E+01 3.000E+00 1.920E+00 1.511E+00 1.710E-03 1.5129E+00 2.202725E-01 9 2.083E+00 9.808E+01 4.000E+00 1.920E+00 2.402E+00 2.044E-03 2.4042E+00 9.033547E-02 10 2.604E+00 9.860E+01 5.000E+00 1.920E+00 3.421E+00 2.310E-03 3.4232E+00 3.260781E-02 11 3.125E+00 9.912E+01 6.000E+00 1.920E+00 4.543E+00 2.523E-03 4.5454E+00 1.061611E-02 12 3.646E+00 9.965E+01 7.000E+00 1.920E+00 5.749E+00 2.696E-03 5.7517E+00 3.177274E-03 13 4.167E+00 1.002E+02 8.000E+00 1.920E+00 7.024E+00 2.837E-03 7.0272E+00 8.874171E-04 14 4.688E+00 1.007E+02 9.000E+00 1.920E+00 8.357E+00 2.953E-03 8.3597E+00 2.341115E-04 15 5.208E+00 1.012E+02 1.000E+01 1.920E+00 9.736E+00 3.049E-03 9.7395E+00 5.890847E-05 16 6.510E+00 1.025E+02 1.250E+01 1.920E+00 1.334E+01 3.222E-03 1.3347E+01 1.597340E-06 17 7.812E+00 1.038E+02 1.500E+01 1.920E+00 1.711E+01 3.331E-03 1.7114E+01 3.694612E-08 18 9.115E+00 1.051E+02 1.750E+01 1.920E+00 2.098E+01 3.402E-03 2.0983E+01 7.714950E-10 19 1.042E+01 1.064E+02 2.000E+01 1.920E+00 2.491E+01 3.447E-03 2.4918E+01 1.507870E-11 20 1.302E+01 1.090E+02 2.500E+01 1.920E+00 3.290E+01 3.495E-03 3.2902E+01 5.139944E-15 21 1.562E+01 1.116E+02 3.000E+01 1.920E+00 4.096E+01 3.516E-03 4.0962E+01 1.623331E-18 22 1.823E+01 1.142E+02 3.500E+01 1.920E+00 4.905E+01 3.525E-03 4.9055E+01 4.962994E-22 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 9.334E-03 8.381E-05 9.4174E-03 9.906268E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 3.139E-02 2.054E-04 3.1597E-02 9.688971E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 8.884E-02 3.980E-04 8.9238E-02 9.146280E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 2.764E-01 7.488E-04 2.7711E-01 7.579717E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 5.526E-01 1.060E-03 5.5365E-01 5.748496E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.091E-01 1.339E-03 9.1041E-01 4.023609E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 1.835E+00 1.816E-03 1.8366E+00 1.593504E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 3.007E+00 2.210E-03 3.0088E+00 4.935281E-02 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 4.388E+00 2.541E-03 4.3905E+00 1.239398E-02 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 5.951E+00 2.823E-03 5.9534E+00 2.596880E-03 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 7.671E+00 3.065E-03 7.6744E+00 4.645469E-04 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 9.531E+00 3.276E-03 9.5347E+00 7.230034E-05 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 1.151E+01 3.462E-03 1.1518E+01 9.945026E-06 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 1.361E+01 3.626E-03 1.3612E+01 1.225107E-06 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 1.926E+01 3.964E-03 1.9260E+01 4.320139E-09 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 2.539E+01 4.227E-03 2.5392E+01 9.379583E-12 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 3.191E+01 4.436E-03 3.1912E+01 1.383509E-14 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 3.874E+01 4.606E-03 3.8745E+01 1.490695E-17 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 5.314E+01 4.867E-03 5.3146E+01 8.294887E-24 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 6.828E+01 5.055E-03 6.8290E+01 2.198012E-30 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 8.398E+01 5.196E-03 8.3982E+01 3.366248E-37 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 4.002E+00 1.000E-01 1.920E+00 9.9067E-01 9.9067E-01 1.0000E+00 9.9067E-01 9.9067E-01 9.9075E-01 3 4.005E+00 2.500E-01 1.920E+00 9.6943E-01 9.6943E-01 1.0000E+00 9.6943E-01 9.6943E-01 9.6963E-01 4 4.011E+00 5.000E-01 1.920E+00 9.1813E-01 9.1813E-01 1.0000E+00 9.1813E-01 9.1813E-01 9.1849E-01 5 4.022E+00 1.000E+00 1.920E+00 7.7626E-01 7.7626E-01 1.0000E+00 7.7626E-01 7.7626E-01 7.7683E-01 6 4.033E+00 1.500E+00 1.920E+00 6.1361E-01 6.1361E-01 1.0000E+00 6.1361E-01 6.1361E-01 6.1424E-01 7 4.043E+00 2.000E+00 1.920E+00 4.5782E-01 4.5782E-01 1.0000E+00 4.5782E-01 4.5782E-01 4.5841E-01 8 4.065E+00 3.000E+00 1.920E+00 2.2027E-01 2.2027E-01 1.0000E+00 2.2027E-01 2.2027E-01 2.2065E-01 9 4.087E+00 4.000E+00 1.920E+00 9.0335E-02 9.0335E-02 1.0000E+00 9.0335E-02 9.0335E-02 9.0520E-02 10 4.109E+00 5.000E+00 1.920E+00 3.2608E-02 3.2608E-02 1.0000E+00 3.2608E-02 3.2608E-02 3.2683E-02 11 4.130E+00 6.000E+00 1.920E+00 1.0616E-02 1.0616E-02 1.0000E+00 1.0616E-02 1.0616E-02 1.0643E-02 12 4.152E+00 7.000E+00 1.920E+00 3.1773E-03 3.1773E-03 1.0000E+00 3.1773E-03 3.1773E-03 3.1859E-03 13 4.174E+00 8.000E+00 1.920E+00 8.8742E-04 8.8742E-04 1.0000E+00 8.8742E-04 8.8742E-04 8.8994E-04 14 4.195E+00 9.000E+00 1.920E+00 2.3411E-04 2.3411E-04 1.0000E+00 2.3411E-04 2.3411E-04 2.3480E-04 15 4.217E+00 1.000E+01 1.920E+00 5.8908E-05 5.8908E-05 1.0000E+00 5.8908E-05 5.8908E-05 5.9088E-05 16 4.271E+00 1.250E+01 1.920E+00 1.5973E-06 1.5973E-06 1.0000E+00 1.5973E-06 1.5973E-06 1.6025E-06 17 4.326E+00 1.500E+01 1.920E+00 3.6946E-08 3.6946E-08 1.0000E+00 3.6946E-08 3.6946E-08 3.7069E-08 18 4.380E+00 1.750E+01 1.920E+00 7.7149E-10 7.7149E-10 1.0000E+00 7.7149E-10 7.7149E-10 7.7412E-10 19 4.434E+00 2.000E+01 1.920E+00 1.5079E-11 1.5079E-11 1.0000E+00 1.5079E-11 1.5079E-11 1.5131E-11 20 4.543E+00 2.500E+01 1.920E+00 5.1399E-15 5.1399E-15 1.0000E+00 5.1399E-15 5.1399E-15 5.1579E-15 21 4.651E+00 3.000E+01 1.920E+00 1.6233E-18 1.6233E-18 1.0000E+00 1.6233E-18 1.6233E-18 1.6290E-18 22 4.760E+00 3.500E+01 1.920E+00 4.9630E-22 4.9630E-22 1.0000E+00 4.9630E-22 4.9630E-22 4.9805E-22 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 4.000E+00 1.000E-01 6.000E+01 9.9063E-01 9.9063E-01 1.0000E+00 9.9063E-01 9.9063E-01 9.9071E-01 25 4.000E+00 2.500E-01 6.000E+01 9.6890E-01 9.6890E-01 1.0000E+00 9.6890E-01 9.6890E-01 9.6910E-01 26 4.000E+00 5.000E-01 6.000E+01 9.1463E-01 9.1463E-01 1.0000E+00 9.1463E-01 9.1463E-01 9.1499E-01 27 4.001E+00 1.000E+00 6.000E+01 7.5797E-01 7.5797E-01 1.0000E+00 7.5797E-01 7.5797E-01 7.5854E-01 28 4.001E+00 1.500E+00 6.000E+01 5.7485E-01 5.7485E-01 1.0000E+00 5.7485E-01 5.7485E-01 5.7546E-01 29 4.001E+00 2.000E+00 6.000E+01 4.0236E-01 4.0236E-01 1.0000E+00 4.0236E-01 4.0236E-01 4.0290E-01 30 4.002E+00 3.000E+00 6.000E+01 1.5935E-01 1.5935E-01 1.0000E+00 1.5935E-01 1.5935E-01 1.5964E-01 31 4.003E+00 4.000E+00 6.000E+01 4.9353E-02 4.9353E-02 1.0000E+00 4.9353E-02 4.9353E-02 4.9462E-02 32 4.003E+00 5.000E+00 6.000E+01 1.2394E-02 1.2394E-02 1.0000E+00 1.2394E-02 1.2394E-02 1.2426E-02 33 4.004E+00 6.000E+00 6.000E+01 2.5969E-03 2.5969E-03 1.0000E+00 2.5969E-03 2.5969E-03 2.6042E-03 34 4.005E+00 7.000E+00 6.000E+01 4.6455E-04 4.6455E-04 1.0000E+00 4.6455E-04 4.6455E-04 4.6597E-04 35 4.006E+00 8.000E+00 6.000E+01 7.2300E-05 7.2300E-05 1.0000E+00 7.2300E-05 7.2300E-05 7.2538E-05 36 4.006E+00 9.000E+00 6.000E+01 9.9450E-06 9.9450E-06 1.0000E+00 9.9450E-06 9.9450E-06 9.9795E-06 37 4.007E+00 1.000E+01 6.000E+01 1.2251E-06 1.2251E-06 1.0000E+00 1.2251E-06 1.2251E-06 1.2296E-06 38 4.009E+00 1.250E+01 6.000E+01 4.3201E-09 4.3201E-09 1.0000E+00 4.3201E-09 4.3201E-09 4.3373E-09 39 4.010E+00 1.500E+01 6.000E+01 9.3796E-12 9.3796E-12 1.0000E+00 9.3796E-12 9.3796E-12 9.4193E-12 40 4.012E+00 1.750E+01 6.000E+01 1.3835E-14 1.3835E-14 1.0000E+00 1.3835E-14 1.3835E-14 1.3897E-14 41 4.014E+00 2.000E+01 6.000E+01 1.4907E-17 1.4907E-17 1.0000E+00 1.4907E-17 1.4907E-17 1.4976E-17 42 4.017E+00 2.500E+01 6.000E+01 8.2949E-24 8.2949E-24 1.0000E+00 8.2949E-24 8.2949E-24 8.3354E-24 43 4.021E+00 3.000E+01 6.000E+01 2.1980E-30 2.1980E-30 1.0000E+00 2.1980E-30 2.1980E-30 2.2092E-30 44 4.024E+00 3.500E+01 6.000E+01 3.3662E-37 3.3662E-37 1.0000E+00 3.3662E-37 3.3662E-37 3.3838E-37 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 1.920E+00 1.494E+00 0.00E+00 1.49371E+00 6.289E-06 6.289E-06 6.348E-06 3 2.500E-01 1.920E+00 3.737E+00 0.00E+00 3.73721E+00 1.540E-05 1.540E-05 1.588E-05 4 5.000E-01 1.920E+00 7.482E+00 0.00E+00 7.48223E+00 2.920E-05 2.920E-05 3.180E-05 5 1.000E+00 1.920E+00 1.499E+01 0.00E+00 1.49868E+01 4.944E-05 4.944E-05 6.369E-05 6 1.500E+00 1.920E+00 2.250E+01 0.00E+00 2.25042E+01 5.868E-05 5.868E-05 9.564E-05 7 2.000E+00 1.920E+00 3.003E+01 0.00E+00 3.00317E+01 5.843E-05 5.843E-05 1.276E-04 8 3.000E+00 1.920E+00 4.511E+01 0.00E+00 4.51126E+01 4.223E-05 4.223E-05 1.917E-04 9 4.000E+00 1.920E+00 6.022E+01 0.00E+00 6.02243E+01 2.312E-05 2.312E-05 2.559E-04 10 5.000E+00 1.920E+00 7.536E+01 0.00E+00 7.53636E+01 1.044E-05 1.044E-05 3.202E-04 11 6.000E+00 1.920E+00 9.053E+01 0.00E+00 9.05272E+01 4.084E-06 4.084E-06 3.847E-04 12 7.000E+00 1.920E+00 1.057E+02 0.00E+00 1.05712E+02 1.427E-06 1.427E-06 4.492E-04 13 8.000E+00 1.920E+00 1.209E+02 0.00E+00 1.20916E+02 4.559E-07 4.559E-07 5.138E-04 14 9.000E+00 1.920E+00 1.361E+02 0.00E+00 1.36137E+02 1.354E-07 1.354E-07 5.784E-04 15 1.000E+01 1.920E+00 1.514E+02 0.00E+00 1.51371E+02 3.789E-08 3.789E-08 6.431E-04 16 1.250E+01 1.920E+00 1.895E+02 0.00E+00 1.89508E+02 1.286E-09 1.286E-09 8.051E-04 17 1.500E+01 1.920E+00 2.277E+02 0.00E+00 2.27699E+02 3.574E-11 3.574E-11 9.673E-04 18 1.750E+01 1.920E+00 2.659E+02 0.00E+00 2.65925E+02 8.714E-13 8.714E-13 1.130E-03 19 2.000E+01 1.920E+00 3.042E+02 0.00E+00 3.04176E+02 1.948E-14 1.948E-14 1.292E-03 20 2.500E+01 1.920E+00 3.807E+02 0.00E+00 3.80719E+02 8.310E-18 8.310E-18 1.617E-03 21 3.000E+01 1.920E+00 4.573E+02 0.00E+00 4.57292E+02 3.152E-21 3.152E-21 1.942E-03 22 3.500E+01 1.920E+00 5.339E+02 0.00E+00 5.33877E+02 1.125E-24 1.125E-24 2.266E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.000E+01 1.494E+00 0.00E+00 1.49377E+00 6.289E-06 6.289E-06 6.348E-06 25 2.500E-01 6.000E+01 3.738E+00 0.00E+00 3.73804E+00 1.539E-05 1.539E-05 1.589E-05 26 5.000E-01 6.000E+01 7.488E+00 0.00E+00 7.48798E+00 2.911E-05 2.911E-05 3.182E-05 27 1.000E+00 6.000E+01 1.502E+01 0.00E+00 1.50225E+01 4.839E-05 4.839E-05 6.384E-05 28 1.500E+00 6.000E+01 2.260E+01 0.00E+00 2.26013E+01 5.521E-05 5.521E-05 9.605E-05 29 2.000E+00 6.000E+01 3.022E+01 0.00E+00 3.02223E+01 5.168E-05 5.168E-05 1.284E-04 30 3.000E+00 6.000E+01 4.558E+01 0.00E+00 4.55836E+01 3.087E-05 3.087E-05 1.937E-04 31 4.000E+00 6.000E+01 6.109E+01 0.00E+00 6.10918E+01 1.281E-05 1.281E-05 2.596E-04 32 5.000E+00 6.000E+01 7.673E+01 0.00E+00 7.67342E+01 4.041E-06 4.041E-06 3.261E-04 33 6.000E+00 6.000E+01 9.250E+01 0.00E+00 9.24993E+01 1.021E-06 1.021E-06 3.930E-04 34 7.000E+00 6.000E+01 1.084E+02 0.00E+00 1.08377E+02 2.139E-07 2.139E-07 4.605E-04 35 8.000E+00 6.000E+01 1.244E+02 0.00E+00 1.24357E+02 3.820E-08 3.820E-08 5.284E-04 36 9.000E+00 6.000E+01 1.404E+02 0.00E+00 1.40432E+02 5.934E-09 5.934E-09 5.967E-04 37 1.000E+01 6.000E+01 1.566E+02 0.00E+00 1.56593E+02 8.151E-10 8.151E-10 6.653E-04 38 1.250E+01 6.000E+01 1.973E+02 0.00E+00 1.97333E+02 3.622E-12 3.622E-12 8.383E-04 39 1.500E+01 6.000E+01 2.385E+02 0.00E+00 2.38482E+02 9.502E-15 9.502E-15 1.013E-03 40 1.750E+01 6.000E+01 2.800E+02 0.00E+00 2.79968E+02 1.645E-17 1.645E-17 1.189E-03 41 2.000E+01 6.000E+01 3.217E+02 0.00E+00 3.21735E+02 2.037E-20 2.037E-20 1.366E-03 42 2.500E+01 6.000E+01 4.059E+02 0.00E+00 4.05941E+02 1.430E-26 1.430E-26 1.724E-03 43 3.000E+01 6.000E+01 4.908E+02 0.00E+00 4.90835E+02 4.580E-33 4.580E-33 2.084E-03 44 3.500E+01 6.000E+01 5.762E+02 0.00E+00 5.76247E+02 8.234E-40 8.234E-40 2.446E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 1.920E+00 1.494E+00 6.289E-06 6.348E-06 6.8995E-05 6.9071E-05 6.8426E-05 3 2.500E-01 1.920E+00 3.737E+00 1.540E-05 1.588E-05 6.8994E-05 6.9184E-05 6.7069E-05 4 5.000E-01 1.920E+00 7.482E+00 2.920E-05 3.180E-05 6.8993E-05 6.9372E-05 6.3693E-05 5 1.000E+00 1.920E+00 1.499E+01 4.944E-05 6.369E-05 6.8991E-05 6.9751E-05 5.4145E-05 6 1.500E+00 1.920E+00 2.250E+01 5.868E-05 9.564E-05 6.8989E-05 7.0129E-05 4.3032E-05 7 2.000E+00 1.920E+00 3.003E+01 5.843E-05 1.276E-04 6.8986E-05 7.0509E-05 3.2280E-05 8 3.000E+00 1.920E+00 4.511E+01 4.223E-05 1.917E-04 6.8982E-05 7.1269E-05 1.5699E-05 9 4.000E+00 1.920E+00 6.022E+01 2.312E-05 2.559E-04 6.8978E-05 7.2030E-05 6.5069E-06 10 5.000E+00 1.920E+00 7.536E+01 1.044E-05 3.202E-04 6.8973E-05 7.2793E-05 2.3736E-06 11 6.000E+00 1.920E+00 9.053E+01 4.084E-06 3.847E-04 6.8969E-05 7.3557E-05 7.8089E-07 12 7.000E+00 1.920E+00 1.057E+02 1.427E-06 4.492E-04 6.8964E-05 7.4322E-05 2.3614E-07 13 8.000E+00 1.920E+00 1.209E+02 4.559E-07 5.138E-04 6.8960E-05 7.5088E-05 6.6634E-08 14 9.000E+00 1.920E+00 1.361E+02 1.354E-07 5.784E-04 6.8955E-05 7.5855E-05 1.7758E-08 15 1.000E+01 1.920E+00 1.514E+02 3.789E-08 6.431E-04 6.8951E-05 7.6622E-05 4.5137E-09 16 1.250E+01 1.920E+00 1.895E+02 1.286E-09 8.051E-04 6.8940E-05 7.8543E-05 1.2546E-10 17 1.500E+01 1.920E+00 2.277E+02 3.574E-11 9.673E-04 6.8928E-05 8.0466E-05 2.9729E-12 18 1.750E+01 1.920E+00 2.659E+02 8.714E-13 1.130E-03 6.8917E-05 8.2391E-05 6.3564E-14 19 2.000E+01 1.920E+00 3.042E+02 1.948E-14 1.292E-03 6.8906E-05 8.4316E-05 1.2714E-15 20 2.500E+01 1.920E+00 3.807E+02 8.310E-18 1.617E-03 6.8884E-05 8.8169E-05 4.5318E-19 21 3.000E+01 1.920E+00 4.573E+02 3.152E-21 1.942E-03 6.8861E-05 9.2021E-05 1.4938E-22 22 3.500E+01 1.920E+00 5.339E+02 1.125E-24 2.266E-03 6.8839E-05 9.5873E-05 4.7582E-26 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.000E+01 1.494E+00 6.289E-06 6.348E-06 6.8995E-05 6.9071E-05 6.8423E-05 25 2.500E-01 6.000E+01 3.738E+00 1.539E-05 1.589E-05 6.8994E-05 6.9184E-05 6.7032E-05 26 5.000E-01 6.000E+01 7.488E+00 2.911E-05 3.182E-05 6.8993E-05 6.9373E-05 6.3450E-05 27 1.000E+00 6.000E+01 1.502E+01 4.839E-05 6.384E-05 6.8991E-05 6.9752E-05 5.2870E-05 28 1.500E+00 6.000E+01 2.260E+01 5.521E-05 9.605E-05 6.8989E-05 7.0134E-05 4.0317E-05 29 2.000E+00 6.000E+01 3.022E+01 5.168E-05 1.284E-04 6.8986E-05 7.0518E-05 2.8374E-05 30 3.000E+00 6.000E+01 4.558E+01 3.087E-05 1.937E-04 6.8982E-05 7.1292E-05 1.1360E-05 31 4.000E+00 6.000E+01 6.109E+01 1.281E-05 2.596E-04 6.8977E-05 7.2074E-05 3.5571E-06 32 5.000E+00 6.000E+01 7.673E+01 4.041E-06 3.261E-04 6.8973E-05 7.2862E-05 9.0305E-07 33 6.000E+00 6.000E+01 9.250E+01 1.021E-06 3.930E-04 6.8968E-05 7.3656E-05 1.9128E-07 34 7.000E+00 6.000E+01 1.084E+02 2.139E-07 4.605E-04 6.8963E-05 7.4456E-05 3.4588E-08 35 8.000E+00 6.000E+01 1.244E+02 3.820E-08 5.284E-04 6.8959E-05 7.5261E-05 5.4414E-09 36 9.000E+00 6.000E+01 1.404E+02 5.934E-09 5.967E-04 6.8954E-05 7.6071E-05 7.5653E-10 37 1.000E+01 6.000E+01 1.566E+02 8.151E-10 6.653E-04 6.8949E-05 7.6885E-05 9.4193E-11 38 1.250E+01 6.000E+01 1.973E+02 3.622E-12 8.383E-04 6.8937E-05 7.8937E-05 3.4102E-13 39 1.500E+01 6.000E+01 2.385E+02 9.502E-15 1.013E-03 6.8925E-05 8.1009E-05 7.5983E-16 40 1.750E+01 6.000E+01 2.800E+02 1.645E-17 1.189E-03 6.8913E-05 8.3098E-05 1.1497E-18 41 2.000E+01 6.000E+01 3.217E+02 2.037E-20 1.366E-03 6.8901E-05 8.5200E-05 1.2701E-21 42 2.500E+01 6.000E+01 4.059E+02 1.430E-26 1.724E-03 6.8876E-05 8.9438E-05 7.4188E-28 43 3.000E+01 6.000E+01 4.908E+02 4.580E-33 2.084E-03 6.8851E-05 9.3708E-05 2.0597E-34 44 3.500E+01 6.000E+01 5.762E+02 8.234E-40 2.446E-03 6.8826E-05 9.8004E-05 3.2990E-41 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.0714 (1/Gy), alpha/beta = 0.3236 (Gy), lamda1 = 4.823E+00 (1/h), lamda2 = 9.764E-02 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 5.208E-02 9.605E+01 1.000E-01 1.920E+00 9.213E-01 9.983E-01 1.013E+00 9.9073E-01 9.906651E-01 3 1.302E-01 9.613E+01 2.500E-01 1.920E+00 8.198E-01 9.958E-01 9.558E-01 9.6940E-01 9.694304E-01 4 2.604E-01 9.626E+01 5.000E-01 1.920E+00 6.856E-01 9.916E-01 9.005E-01 9.1682E-01 9.181278E-01 5 5.208E-01 9.652E+01 1.000E+00 1.920E+00 5.049E-01 9.833E-01 8.236E-01 7.6645E-01 7.762634E-01 6 7.812E-01 9.678E+01 1.500E+00 1.920E+00 3.932E-01 9.751E-01 7.675E-01 5.8870E-01 6.136092E-01 7 1.042E+00 9.704E+01 2.000E+00 1.920E+00 3.194E-01 9.669E-01 7.229E-01 4.1695E-01 4.578213E-01 8 1.562E+00 9.756E+01 3.000E+00 1.920E+00 2.302E-01 9.510E-01 6.535E-01 1.6555E-01 2.202725E-01 9 2.083E+00 9.808E+01 4.000E+00 1.920E+00 1.792E-01 9.355E-01 5.997E-01 4.8778E-02 9.033547E-02 10 2.604E+00 9.860E+01 5.000E+00 1.920E+00 1.465E-01 9.204E-01 5.555E-01 1.0824E-02 3.260781E-02 11 3.125E+00 9.912E+01 6.000E+00 1.920E+00 1.239E-01 9.056E-01 5.180E-01 1.8345E-03 1.061611E-02 12 3.646E+00 9.965E+01 7.000E+00 1.920E+00 1.073E-01 8.912E-01 4.855E-01 2.4069E-04 3.177274E-03 13 4.167E+00 1.002E+02 8.000E+00 1.920E+00 9.456E-02 8.771E-01 4.569E-01 2.4757E-05 8.874171E-04 14 4.688E+00 1.007E+02 9.000E+00 1.920E+00 8.455E-02 8.634E-01 4.315E-01 2.0206E-06 2.341115E-04 15 5.208E+00 1.012E+02 1.000E+01 1.920E+00 7.644E-02 8.500E-01 4.088E-01 1.3237E-07 5.890847E-05 16 6.510E+00 1.025E+02 1.250E+01 1.920E+00 6.166E-02 8.179E-01 3.610E-01 5.9614E-11 1.597340E-06 17 7.812E+00 1.038E+02 1.500E+01 1.920E+00 5.167E-02 7.877E-01 3.229E-01 8.4901E-15 3.694612E-08 18 9.115E+00 1.051E+02 1.750E+01 1.920E+00 4.446E-02 7.591E-01 2.918E-01 4.3871E-19 7.714950E-10 19 1.042E+01 1.064E+02 2.000E+01 1.920E+00 3.901E-02 7.322E-01 2.660E-01 9.2836E-24 1.507870E-11 20 1.302E+01 1.090E+02 2.500E+01 1.920E+00 3.134E-02 6.828E-01 2.255E-01 4.3175E-34 5.139944E-15 21 1.562E+01 1.116E+02 3.000E+01 1.920E+00 2.619E-02 6.385E-01 1.954E-01 1.7352E-45 1.623331E-18 22 1.823E+01 1.142E+02 3.500E+01 1.920E+00 2.249E-02 5.988E-01 1.721E-01 1.0442E-57 4.962994E-22 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 9.973E-01 9.999E-01 1.030E+00 9.9069E-01 9.906268E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 9.933E-01 9.999E-01 9.957E-01 9.6886E-01 9.688971E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.867E-01 9.997E-01 9.697E-01 9.1325E-01 9.146280E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 9.737E-01 9.995E-01 9.316E-01 7.4761E-01 7.579717E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 9.610E-01 9.992E-01 8.988E-01 5.4912E-01 5.748496E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.485E-01 9.989E-01 8.691E-01 3.6222E-01 4.023609E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 9.242E-01 9.984E-01 8.165E-01 1.1456E-01 1.593504E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 9.009E-01 9.978E-01 7.709E-01 2.3815E-02 4.935281E-02 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 8.785E-01 9.973E-01 7.308E-01 3.2740E-03 1.239398E-02 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 8.569E-01 9.968E-01 6.951E-01 2.9944E-04 2.596880E-03 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 8.361E-01 9.962E-01 6.632E-01 1.8318E-05 4.645469E-04 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 8.161E-01 9.957E-01 6.344E-01 7.5333E-07 7.230034E-05 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 7.968E-01 9.951E-01 6.082E-01 2.0925E-08 9.945026E-06 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 7.783E-01 9.946E-01 5.842E-01 3.9430E-10 1.225107E-06 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 7.348E-01 9.933E-01 5.324E-01 3.6128E-15 4.320139E-09 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 6.950E-01 9.919E-01 4.896E-01 3.1773E-21 9.379583E-12 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 6.586E-01 9.906E-01 4.535E-01 2.8140E-28 1.383509E-14 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 6.252E-01 9.892E-01 4.226E-01 2.6144E-36 1.490695E-17 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 5.664E-01 9.866E-01 3.722E-01 2.9808E-55 8.294887E-24 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 5.163E-01 9.839E-01 3.329E-01 5.9054E-78 2.198012E-30 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 4.733E-01 9.813E-01 3.013E-01 0.0000E+00 3.366248E-37 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 4.002E+00 1.000E-01 9.9067E-01 9.9067E-01 9.9075E-01 3.7133E-01 3.7133E-01 3.7130E-01 3.7130E-01 3 4.005E+00 2.500E-01 9.6943E-01 9.6943E-01 9.6963E-01 3.7930E-01 3.7930E-01 3.7922E-01 3.7922E-01 4 4.011E+00 5.000E-01 9.1813E-01 9.1813E-01 9.1849E-01 3.9927E-01 3.9927E-01 3.9912E-01 3.9912E-01 5 4.022E+00 1.000E+00 7.7626E-01 7.7626E-01 7.7683E-01 4.6012E-01 4.6012E-01 4.5986E-01 4.5986E-01 6 4.033E+00 1.500E+00 6.1361E-01 6.1361E-01 6.1424E-01 5.4139E-01 5.4139E-01 5.4105E-01 5.4105E-01 7 4.043E+00 2.000E+00 4.5782E-01 4.5782E-01 4.5841E-01 6.3266E-01 6.3266E-01 6.3229E-01 6.3229E-01 8 4.065E+00 3.000E+00 2.2027E-01 2.2027E-01 2.2065E-01 8.0230E-01 8.0230E-01 8.0200E-01 8.0200E-01 9 4.087E+00 4.000E+00 9.0335E-02 9.0335E-02 9.0520E-02 9.1362E-01 9.1362E-01 9.1346E-01 9.1346E-01 10 4.109E+00 5.000E+00 3.2608E-02 3.2608E-02 3.2683E-02 9.6792E-01 9.6792E-01 9.6785E-01 9.6785E-01 11 4.130E+00 6.000E+00 1.0616E-02 1.0616E-02 1.0643E-02 9.8944E-01 9.8944E-01 9.8941E-01 9.8941E-01 12 4.152E+00 7.000E+00 3.1773E-03 3.1773E-03 3.1859E-03 9.9683E-01 9.9683E-01 9.9682E-01 9.9682E-01 13 4.174E+00 8.000E+00 8.8742E-04 8.8742E-04 8.8994E-04 9.9911E-01 9.9911E-01 9.9911E-01 9.9911E-01 14 4.195E+00 9.000E+00 2.3411E-04 2.3411E-04 2.3480E-04 9.9977E-01 9.9977E-01 9.9977E-01 9.9977E-01 15 4.217E+00 1.000E+01 5.8908E-05 5.8908E-05 5.9088E-05 9.9994E-01 9.9994E-01 9.9994E-01 9.9994E-01 16 4.271E+00 1.250E+01 1.5973E-06 1.5973E-06 1.6025E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 17 4.326E+00 1.500E+01 3.6946E-08 3.6946E-08 3.7069E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 18 4.380E+00 1.750E+01 7.7149E-10 7.7149E-10 7.7412E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 19 4.434E+00 2.000E+01 1.5079E-11 1.5079E-11 1.5131E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 20 4.543E+00 2.500E+01 5.1399E-15 5.1399E-15 5.1579E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 4.651E+00 3.000E+01 1.6233E-18 1.6233E-18 1.6290E-18 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 4.760E+00 3.500E+01 4.9630E-22 4.9630E-22 4.9805E-22 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 4.000E+00 1.000E-01 9.9063E-01 9.9063E-01 9.9071E-01 3.7134E-01 3.7134E-01 3.7131E-01 3.7131E-01 25 4.000E+00 2.500E-01 9.6890E-01 9.6890E-01 9.6910E-01 3.7950E-01 3.7950E-01 3.7943E-01 3.7943E-01 26 4.000E+00 5.000E-01 9.1463E-01 9.1463E-01 9.1499E-01 4.0067E-01 4.0067E-01 4.0052E-01 4.0052E-01 27 4.001E+00 1.000E+00 7.5797E-01 7.5797E-01 7.5854E-01 4.6862E-01 4.6862E-01 4.6835E-01 4.6835E-01 28 4.001E+00 1.500E+00 5.7485E-01 5.7485E-01 5.7546E-01 5.6279E-01 5.6279E-01 5.6245E-01 5.6245E-01 29 4.001E+00 2.000E+00 4.0236E-01 4.0236E-01 4.0290E-01 6.6874E-01 6.6874E-01 6.6838E-01 6.6838E-01 30 4.002E+00 3.000E+00 1.5935E-01 1.5935E-01 1.5964E-01 8.5270E-01 8.5270E-01 8.5245E-01 8.5245E-01 31 4.003E+00 4.000E+00 4.9353E-02 4.9353E-02 4.9462E-02 9.5185E-01 9.5185E-01 9.5174E-01 9.5174E-01 32 4.003E+00 5.000E+00 1.2394E-02 1.2394E-02 1.2426E-02 9.8768E-01 9.8768E-01 9.8765E-01 9.8765E-01 33 4.004E+00 6.000E+00 2.5969E-03 2.5969E-03 2.6042E-03 9.9741E-01 9.9741E-01 9.9740E-01 9.9740E-01 34 4.005E+00 7.000E+00 4.6455E-04 4.6455E-04 4.6597E-04 9.9954E-01 9.9954E-01 9.9953E-01 9.9953E-01 35 4.006E+00 8.000E+00 7.2300E-05 7.2300E-05 7.2538E-05 9.9993E-01 9.9993E-01 9.9993E-01 9.9993E-01 36 4.006E+00 9.000E+00 9.9450E-06 9.9450E-06 9.9795E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 37 4.007E+00 1.000E+01 1.2251E-06 1.2251E-06 1.2296E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 38 4.009E+00 1.250E+01 4.3201E-09 4.3201E-09 4.3373E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 39 4.010E+00 1.500E+01 9.3796E-12 9.3796E-12 9.4193E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 40 4.012E+00 1.750E+01 1.3835E-14 1.3835E-14 1.3897E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 4.014E+00 2.000E+01 1.4907E-17 1.4907E-17 1.4976E-17 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 4.017E+00 2.500E+01 8.2949E-24 8.2949E-24 8.3354E-24 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.021E+00 3.000E+01 2.1980E-30 2.1980E-30 2.2092E-30 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.024E+00 3.500E+01 3.3662E-37 3.3662E-37 3.3838E-37 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 5.208E-02 2.170E-03 0.0000E+00 1.0000E-01 0.0000E+00 1.9200E+00 3 1.302E-01 5.425E-03 0.0000E+00 2.5000E-01 0.0000E+00 1.9200E+00 4 2.604E-01 1.085E-02 0.0000E+00 5.0000E-01 0.0000E+00 1.9200E+00 5 5.208E-01 2.170E-02 0.0000E+00 1.0000E+00 0.0000E+00 1.9200E+00 6 7.812E-01 3.255E-02 0.0000E+00 1.5000E+00 0.0000E+00 1.9200E+00 7 1.042E+00 4.340E-02 0.0000E+00 2.0000E+00 0.0000E+00 1.9200E+00 8 1.562E+00 6.510E-02 0.0000E+00 3.0000E+00 0.0000E+00 1.9200E+00 9 2.083E+00 8.681E-02 0.0000E+00 4.0000E+00 0.0000E+00 1.9200E+00 10 2.604E+00 1.085E-01 0.0000E+00 5.0000E+00 0.0000E+00 1.9200E+00 11 3.125E+00 1.302E-01 0.0000E+00 6.0000E+00 0.0000E+00 1.9200E+00 12 3.646E+00 1.519E-01 0.0000E+00 7.0000E+00 0.0000E+00 1.9200E+00 13 4.167E+00 1.736E-01 0.0000E+00 8.0000E+00 0.0000E+00 1.9200E+00 14 4.688E+00 1.953E-01 0.0000E+00 9.0000E+00 0.0000E+00 1.9200E+00 15 5.208E+00 2.170E-01 0.0000E+00 1.0000E+01 0.0000E+00 1.9200E+00 16 6.510E+00 2.713E-01 0.0000E+00 1.2500E+01 0.0000E+00 1.9200E+00 17 7.812E+00 3.255E-01 0.0000E+00 1.5000E+01 0.0000E+00 1.9200E+00 18 9.115E+00 3.798E-01 0.0000E+00 1.7500E+01 0.0000E+00 1.9200E+00 19 1.042E+01 4.340E-01 0.0000E+00 2.0000E+01 0.0000E+00 1.9200E+00 20 1.302E+01 5.425E-01 0.0000E+00 2.5000E+01 0.0000E+00 1.9200E+00 21 1.562E+01 6.510E-01 0.0000E+00 3.0000E+01 0.0000E+00 1.9200E+00 22 1.823E+01 7.595E-01 0.0000E+00 3.5000E+01 0.0000E+00 1.9200E+00 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.667E-03 6.944E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E+01 25 4.167E-03 1.736E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E+01 26 8.333E-03 3.472E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E+01 27 1.667E-02 6.944E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E+01 28 2.500E-02 1.042E-03 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E+01 29 3.333E-02 1.389E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E+01 30 5.000E-02 2.083E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E+01 31 6.667E-02 2.778E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E+01 32 8.333E-02 3.472E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E+01 33 1.000E-01 4.167E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E+01 34 1.167E-01 4.861E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E+01 35 1.333E-01 5.556E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E+01 36 1.500E-01 6.250E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E+01 37 1.667E-01 6.944E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E+01 38 2.083E-01 8.681E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E+01 39 2.500E-01 1.042E-02 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E+01 40 2.917E-01 1.215E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E+01 41 3.333E-01 1.389E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E+01 42 4.167E-01 1.736E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E+01 43 5.000E-01 2.083E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E+01 44 5.833E-01 2.431E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 8.85000E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 08:43:24 PM