VC 2.00I 15-JUL-2003 02-AUG-2003 08:40:09 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\hx160c.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\hx160c.radx (12 exposures) XDAT: ..\xdat\hx160c.xdat (12 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E+00 2.00000E-04 1.2292998E-03 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 4.7622082E-03 2201 CLRP RHT 1.00000E-02 2.40000E+01 1.50000E-01 1.4370717E-01 2202 CLRP RHT 1.00000E-02 2.40000E+01 1.00000E+00 7.0988963E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 1.40869E-02 (nfom=668, nsim=8016, nmx=12, nox=12, ndf=7, nap=4) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-4.016E-01 max=2.136E-01, mean=3.8985E-02, stdev=1.7180E-01, var=2.9515E-02 Student's T test (mean=0, NDF=7): Pr>ABS(0.78607)= 4.5760E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.84629)=3.057E-02 (normality questionable) COMBINED WEIGHTED RESIDUAL: Stats: min=-1.159E-01 max=6.166E-02, mean=1.1254E-02, stdev=4.9594E-02, var=2.4596E-03 Student's T test (mean=0, NDF=7): Pr>ABS(0.78607)= 4.5760E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.84629)=3.057E-02 (normality questionable) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 4.762208E-03 (=0.476%) PHI2= 4.762208E-03 (=0.476%) (1-A1)*PHI1= 1.190552E-03 (=0.119%) (1-A2)*PHI2= 3.571656E-03 (=0.357%) (1-A1)*(1-PHI1)= 2.488094E-01 (=24.881%) (1-A2)*(1-PHI2)= 7.464283E-01 (=74.643%) RHT1= 0.143707 h (=8.62 minute) RHT2= 7.098896 h (=425.93 minute) LAM1= 4.8233307E+00 (1/h) LAM2= 9.7641542E-02 (1/h) BMR= 1.2292998E-03 (1/h) LAM1/BMR= 3.9236406E+03 LAM2/BMR= 7.9428582E+01 (LAM1+LAM2)/BMR= 4.0030692E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 3.5717E-02 + 3.5717E-02 = 7.1433123E-02 (1/Gy) beta: 4.7093E-02 + 1.7368E-01 = 2.2077590E-01 (1/Gy^2) alpha/beta: 0.3235549 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (HX 160C cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 1.0729E+00 2.0600E+00 1.9200E+00 3.81739E-01 8.33E-02 4.40456E-01 1.3331E-01 2 2.0625E+00 3.9600E+00 1.9200E+00 1.31560E-01 8.33E-02 9.38614E-02 -4.0164E-01 3 2.5677E+00 4.9300E+00 1.9200E+00 3.56650E-02 8.33E-02 3.51452E-02 -1.4789E-02 4 3.0625E+00 5.8800E+00 1.9200E+00 1.12150E-02 8.33E-02 1.22046E-02 8.1083E-02 5 3.5469E+00 6.8100E+00 1.9200E+00 3.63700E-03 8.33E-02 4.01871E-03 9.4984E-02 6 4.0677E+00 7.8100E+00 1.9200E+00 1.08700E-03 8.33E-02 1.13612E-03 4.3237E-02 7 1.8667E-02 1.1200E+00 6.0000E+01 6.50261E-01 8.33E-02 7.14814E-01 9.0307E-02 8 3.4333E-02 2.0600E+00 6.0000E+01 3.12680E-01 8.33E-02 3.83562E-01 1.8480E-01 9 5.0000E-02 3.0000E+00 6.0000E+01 1.27644E-01 8.33E-02 1.59350E-01 1.9897E-01 10 6.6167E-02 3.9700E+00 6.0000E+01 5.23750E-02 8.33E-02 5.12835E-02 -2.1284E-02 11 8.1500E-02 4.8900E+00 6.0000E+01 1.14530E-02 8.33E-02 1.45638E-02 2.1360E-01 12 9.7167E-02 5.8300E+00 6.0000E+01 3.88900E-03 8.33E-02 3.42716E-03 -1.3476E-01 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-4.016E-01 max=2.136E-01, mean=3.8985E-02, stdev=1.7180E-01, var=2.9515E-02 Student's T test (mean=0, NDF=7): Pr>ABS(0.78607)= 4.5760E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.84629)=3.057E-02 (normality questionable) WEIGHTED RESIDUAL: Stats: min=-1.159E-01 max=6.166E-02, mean=1.1254E-02, stdev=4.9594E-02, var=2.4596E-03 Student's T test (mean=0, NDF=7): Pr>ABS(0.78607)= 4.5760E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.84629)=3.057E-02 (normality questionable) NOX=12, NPAR=4 CFE.SF: Cell survival data for HX 160C cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 1.0729E+00 2.0600E+00 1.9200E+00 6.18261E-01 3.81739E-01 1.00E+01 2 2 2.0625E+00 3.9600E+00 1.9200E+00 8.68440E-01 1.31560E-01 1.00E+01 3 3 2.5677E+00 4.9300E+00 1.9200E+00 9.64335E-01 3.56650E-02 1.00E+01 4 4 3.0625E+00 5.8800E+00 1.9200E+00 9.88785E-01 1.12150E-02 1.00E+01 5 5 3.5469E+00 6.8100E+00 1.9200E+00 9.96363E-01 3.63700E-03 1.00E+01 6 6 4.0677E+00 7.8100E+00 1.9200E+00 9.98913E-01 1.08700E-03 1.00E+01 7 7 1.8667E-02 1.1200E+00 6.0000E+01 3.49739E-01 6.50261E-01 1.00E+01 8 8 3.4333E-02 2.0600E+00 6.0000E+01 6.87320E-01 3.12680E-01 1.00E+01 9 9 5.0000E-02 3.0000E+00 6.0000E+01 8.72356E-01 1.27644E-01 1.00E+01 10 10 6.6167E-02 3.9700E+00 6.0000E+01 9.47625E-01 5.23750E-02 1.00E+01 11 11 8.1500E-02 4.8900E+00 6.0000E+01 9.88547E-01 1.14530E-02 1.00E+01 12 12 9.7167E-02 5.8300E+00 6.0000E+01 9.96111E-01 3.88900E-03 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (HX 160C). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 1.073E+00 1.200E+01 4.000E+02 2.0600E+00 4.6748E-01 9.6302E-01 2 2 2.062E+00 1.200E+01 4.000E+02 3.9600E+00 5.1220E-01 2.0283E+00 3 3 2.568E+00 1.200E+01 4.000E+02 4.9300E+00 6.7618E-01 3.3336E+00 4 4 3.062E+00 1.200E+01 4.000E+02 5.8800E+00 7.6369E-01 4.4905E+00 5 5 3.547E+00 1.200E+01 4.000E+02 6.8100E+00 8.2476E-01 5.6166E+00 6 6 4.068E+00 1.200E+01 4.000E+02 7.8100E+00 8.7379E-01 6.8243E+00 7 7 1.867E-02 1.200E+01 4.000E+02 1.1200E+00 3.8427E-01 4.3038E-01 8 8 3.433E-02 1.200E+01 4.000E+02 2.0600E+00 5.6436E-01 1.1626E+00 9 9 5.000E-02 1.200E+01 4.000E+02 3.0000E+00 6.8617E-01 2.0585E+00 10 10 6.617E-02 1.200E+01 4.000E+02 3.9700E+00 7.4290E-01 2.9493E+00 11 11 8.150E-02 1.200E+01 4.000E+02 4.8900E+00 9.1401E-01 4.4695E+00 12 12 9.717E-02 1.200E+01 4.000E+02 5.8300E+00 9.5190E-01 5.5496E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.98853 VC 2.00I 15-JUL-2003 02-AUG-2003 08:41:09 PM