VC 2.00I 15-JUL-2003 02-AUG-2003 08:30:41 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\hx156c\tlk\hx156c.inp FNI: U:\archive\hx156c\tlk\hx156c.inp FNO: U:\archive\hx156c\tlk\hx156c.out RADX: U:\archive\hx156c\tlk\hx156c.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 5.74228E-12 3.52920E-03 20.000000 Complex DSB = 1.43557E-12 8.82301E-04 5.000000 Total DSB = 7.17785E-12 4.41151E-03 25.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 2.178444E-02 (=2.178%) PHI2= 2.178444E-02 (=2.178%) (1-A1)*PHI1= 5.446110E-03 (=0.545%) (1-A2)*PHI2= 1.633833E-02 (=1.634%) (1-A1)*(1-PHI1)= 2.445539E-01 (=24.455%) (1-A2)*(1-PHI2)= 7.336617E-01 (=73.366%) RHT1= 0.100000 h (=6.00 minute) RHT2= 2.789370 h (=167.36 minute) LAM1= 6.9314718E+00 (1/h) LAM2= 2.4849595E-01 (1/h) BMR= 1.9214372E-03 (1/h) LAM1/BMR= 3.6074412E+03 LAM2/BMR= 1.2932817E+02 (LAM1+LAM2)/BMR= 3.7367694E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.0892E-01 + 8.1692E-02 = 1.9061384E-01 (1/Gy) beta: 1.9957E-02 + 2.8983E-02 = 4.8940051E-02 (1/Gy^2) alpha/beta: 3.8948435 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 5.208E-02 8.405E+01 1.000E-01 1.920E+00 1.953E-02 1.520E-10 1.9527E-02 9.806628E-01 3 1.302E-01 9.613E+01 2.500E-01 1.920E+00 5.037E-02 9.544E-11 5.0375E-02 9.508728E-01 4 2.604E-01 9.626E+01 5.000E-01 1.920E+00 1.053E-01 3.914E-10 1.0526E-01 9.000870E-01 5 5.208E-01 9.652E+01 1.000E+00 1.920E+00 2.257E-01 5.966E-10 2.2571E-01 7.979480E-01 6 7.812E-01 9.678E+01 1.500E+00 1.920E+00 3.583E-01 8.760E-10 3.5830E-01 6.988634E-01 7 1.042E+00 9.704E+01 2.000E+00 1.920E+00 5.016E-01 5.492E-11 5.0161E-01 6.055572E-01 8 1.562E+00 9.756E+01 3.000E+00 1.920E+00 8.162E-01 2.280E-10 8.1625E-01 4.420871E-01 9 2.083E+00 9.808E+01 4.000E+00 1.920E+00 1.163E+00 4.082E-10 1.1626E+00 3.126859E-01 10 2.604E+00 9.860E+01 5.000E+00 1.920E+00 1.535E+00 5.320E-10 1.5348E+00 2.154950E-01 11 3.125E+00 9.912E+01 6.000E+00 1.920E+00 1.928E+00 6.398E-10 1.9284E+00 1.453851E-01 12 3.646E+00 9.965E+01 7.000E+00 1.920E+00 2.339E+00 2.111E-10 2.3394E+00 9.638583E-02 13 4.167E+00 1.002E+02 8.000E+00 1.920E+00 2.765E+00 2.356E-10 2.7648E+00 6.299034E-02 14 4.688E+00 1.007E+02 9.000E+00 1.920E+00 3.202E+00 2.612E-10 3.2019E+00 4.068319E-02 15 5.208E+00 1.012E+02 1.000E+01 1.920E+00 3.649E+00 2.840E-10 3.6488E+00 2.602251E-02 16 6.510E+00 1.025E+02 1.250E+01 1.920E+00 4.798E+00 3.290E-10 4.7977E+00 8.248480E-03 17 7.812E+00 1.038E+02 1.500E+01 1.920E+00 5.978E+00 3.592E-10 5.9777E+00 2.534749E-03 18 9.115E+00 1.051E+02 1.750E+01 1.920E+00 7.177E+00 3.788E-10 7.1766E+00 7.642624E-04 19 1.042E+01 1.064E+02 2.000E+01 1.920E+00 8.387E+00 3.911E-10 8.3872E+00 2.277661E-04 20 1.302E+01 1.090E+02 2.500E+01 1.920E+00 1.083E+01 4.036E-10 1.0827E+01 1.985501E-05 21 1.562E+01 1.116E+02 3.000E+01 1.920E+00 1.328E+01 4.084E-10 1.3278E+01 1.711178E-06 22 1.823E+01 1.142E+02 3.500E+01 1.920E+00 1.573E+01 4.102E-10 1.5734E+01 1.468436E-07 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.667E-03 8.400E+01 1.000E-01 6.000E+01 1.955E-02 1.558E-10 1.9549E-02 9.806408E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 5.068E-02 9.932E-11 5.0684E-02 9.505786E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 1.073E-01 4.031E-10 1.0732E-01 8.982369E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 2.378E-01 6.422E-10 2.3782E-01 7.883438E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 3.903E-01 9.574E-10 3.9029E-01 6.768619E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 5.636E-01 1.141E-10 5.6359E-01 5.691598E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 9.686E-01 3.825E-10 9.6858E-01 3.796218E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 1.445E+00 6.235E-10 1.4452E+00 2.357095E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 1.987E+00 2.579E-10 1.9866E+00 1.371549E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 2.587E+00 3.694E-10 2.5872E+00 7.523158E-02 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 3.242E+00 5.035E-10 3.2416E+00 3.910107E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 3.945E+00 6.053E-10 3.9453E+00 1.934466E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 4.694E+00 6.669E-10 4.6943E+00 9.146965E-03 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 5.485E+00 7.287E-10 5.4850E+00 4.148586E-03 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 7.624E+00 8.875E-10 7.6236E+00 4.887550E-04 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 9.962E+00 2.356E-09 9.9619E+00 4.716333E-05 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 1.247E+01 2.569E-09 1.2468E+01 3.848612E-06 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 1.512E+01 2.766E-09 1.5117E+01 2.722554E-07 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 2.077E+01 3.019E-09 2.0768E+01 9.563631E-10 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 2.680E+01 3.256E-09 2.6800E+01 2.294972E-12 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 3.314E+01 3.475E-09 3.3135E+01 4.068587E-15 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 3.502E+00 1.000E-01 1.920E+00 9.8066E-01 9.8066E-01 1.0000E+00 9.8066E-01 9.8066E-01 9.8066E-01 3 4.005E+00 2.500E-01 1.920E+00 9.5087E-01 9.5087E-01 1.0000E+00 9.5087E-01 9.5087E-01 9.5087E-01 4 4.011E+00 5.000E-01 1.920E+00 9.0009E-01 9.0009E-01 1.0000E+00 9.0009E-01 9.0009E-01 9.0009E-01 5 4.022E+00 1.000E+00 1.920E+00 7.9795E-01 7.9795E-01 1.0000E+00 7.9795E-01 7.9795E-01 7.9795E-01 6 4.033E+00 1.500E+00 1.920E+00 6.9886E-01 6.9886E-01 1.0000E+00 6.9886E-01 6.9886E-01 6.9886E-01 7 4.043E+00 2.000E+00 1.920E+00 6.0556E-01 6.0556E-01 1.0000E+00 6.0556E-01 6.0556E-01 6.0556E-01 8 4.065E+00 3.000E+00 1.920E+00 4.4209E-01 4.4209E-01 1.0000E+00 4.4209E-01 4.4209E-01 4.4209E-01 9 4.087E+00 4.000E+00 1.920E+00 3.1269E-01 3.1269E-01 1.0000E+00 3.1269E-01 3.1269E-01 3.1269E-01 10 4.109E+00 5.000E+00 1.920E+00 2.1550E-01 2.1550E-01 1.0000E+00 2.1550E-01 2.1550E-01 2.1550E-01 11 4.130E+00 6.000E+00 1.920E+00 1.4539E-01 1.4539E-01 1.0000E+00 1.4539E-01 1.4539E-01 1.4539E-01 12 4.152E+00 7.000E+00 1.920E+00 9.6386E-02 9.6386E-02 1.0000E+00 9.6386E-02 9.6386E-02 9.6386E-02 13 4.174E+00 8.000E+00 1.920E+00 6.2990E-02 6.2990E-02 1.0000E+00 6.2990E-02 6.2990E-02 6.2990E-02 14 4.195E+00 9.000E+00 1.920E+00 4.0683E-02 4.0683E-02 1.0000E+00 4.0683E-02 4.0683E-02 4.0683E-02 15 4.217E+00 1.000E+01 1.920E+00 2.6023E-02 2.6023E-02 1.0000E+00 2.6023E-02 2.6023E-02 2.6023E-02 16 4.271E+00 1.250E+01 1.920E+00 8.2485E-03 8.2485E-03 1.0000E+00 8.2485E-03 8.2485E-03 8.2485E-03 17 4.326E+00 1.500E+01 1.920E+00 2.5347E-03 2.5347E-03 1.0000E+00 2.5347E-03 2.5347E-03 2.5347E-03 18 4.380E+00 1.750E+01 1.920E+00 7.6426E-04 7.6426E-04 1.0000E+00 7.6426E-04 7.6426E-04 7.6426E-04 19 4.434E+00 2.000E+01 1.920E+00 2.2777E-04 2.2777E-04 1.0000E+00 2.2777E-04 2.2777E-04 2.2777E-04 20 4.543E+00 2.500E+01 1.920E+00 1.9855E-05 1.9855E-05 1.0000E+00 1.9855E-05 1.9855E-05 1.9855E-05 21 4.651E+00 3.000E+01 1.920E+00 1.7112E-06 1.7112E-06 1.0000E+00 1.7112E-06 1.7112E-06 1.7112E-06 22 4.760E+00 3.500E+01 1.920E+00 1.4684E-07 1.4684E-07 1.0000E+00 1.4684E-07 1.4684E-07 1.4684E-07 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 3.500E+00 1.000E-01 6.000E+01 9.8064E-01 9.8064E-01 1.0000E+00 9.8064E-01 9.8064E-01 9.8064E-01 25 4.000E+00 2.500E-01 6.000E+01 9.5058E-01 9.5058E-01 1.0000E+00 9.5058E-01 9.5058E-01 9.5058E-01 26 4.000E+00 5.000E-01 6.000E+01 8.9824E-01 8.9824E-01 1.0000E+00 8.9824E-01 8.9824E-01 8.9824E-01 27 4.001E+00 1.000E+00 6.000E+01 7.8834E-01 7.8834E-01 1.0000E+00 7.8834E-01 7.8834E-01 7.8834E-01 28 4.001E+00 1.500E+00 6.000E+01 6.7686E-01 6.7686E-01 1.0000E+00 6.7686E-01 6.7686E-01 6.7686E-01 29 4.001E+00 2.000E+00 6.000E+01 5.6916E-01 5.6916E-01 1.0000E+00 5.6916E-01 5.6916E-01 5.6916E-01 30 4.002E+00 3.000E+00 6.000E+01 3.7962E-01 3.7962E-01 1.0000E+00 3.7962E-01 3.7962E-01 3.7962E-01 31 4.003E+00 4.000E+00 6.000E+01 2.3571E-01 2.3571E-01 1.0000E+00 2.3571E-01 2.3571E-01 2.3571E-01 32 4.003E+00 5.000E+00 6.000E+01 1.3715E-01 1.3715E-01 1.0000E+00 1.3715E-01 1.3715E-01 1.3715E-01 33 4.004E+00 6.000E+00 6.000E+01 7.5232E-02 7.5232E-02 1.0000E+00 7.5232E-02 7.5232E-02 7.5232E-02 34 4.005E+00 7.000E+00 6.000E+01 3.9101E-02 3.9101E-02 1.0000E+00 3.9101E-02 3.9101E-02 3.9101E-02 35 4.006E+00 8.000E+00 6.000E+01 1.9345E-02 1.9345E-02 1.0000E+00 1.9345E-02 1.9345E-02 1.9345E-02 36 4.006E+00 9.000E+00 6.000E+01 9.1470E-03 9.1470E-03 1.0000E+00 9.1470E-03 9.1470E-03 9.1470E-03 37 4.007E+00 1.000E+01 6.000E+01 4.1486E-03 4.1486E-03 1.0000E+00 4.1486E-03 4.1486E-03 4.1486E-03 38 4.009E+00 1.250E+01 6.000E+01 4.8875E-04 4.8875E-04 1.0000E+00 4.8875E-04 4.8875E-04 4.8875E-04 39 4.010E+00 1.500E+01 6.000E+01 4.7163E-05 4.7163E-05 1.0000E+00 4.7163E-05 4.7163E-05 4.7163E-05 40 4.012E+00 1.750E+01 6.000E+01 3.8486E-06 3.8486E-06 1.0000E+00 3.8486E-06 3.8486E-06 3.8486E-06 41 4.014E+00 2.000E+01 6.000E+01 2.7226E-07 2.7226E-07 1.0000E+00 2.7226E-07 2.7226E-07 2.7226E-07 42 4.017E+00 2.500E+01 6.000E+01 9.5636E-10 9.5636E-10 1.0000E+00 9.5636E-10 9.5636E-10 9.5636E-10 43 4.021E+00 3.000E+01 6.000E+01 2.2950E-12 2.2950E-12 1.0000E+00 2.2950E-12 2.2950E-12 2.2950E-12 44 4.024E+00 3.500E+01 6.000E+01 4.0686E-15 4.0686E-15 1.0000E+00 4.0686E-15 4.0686E-15 4.0686E-15 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 1.920E+00 8.563E-01 0.00E+00 8.56335E-01 3.569E-06 3.569E-06 3.639E-06 3 2.500E-01 1.920E+00 2.142E+00 0.00E+00 2.14203E+00 8.656E-06 8.656E-06 9.104E-06 4 5.000E-01 1.920E+00 4.287E+00 0.00E+00 4.28697E+00 1.640E-05 1.640E-05 1.822E-05 5 1.000E+00 1.920E+00 8.582E+00 0.00E+00 8.58161E+00 2.910E-05 2.910E-05 3.647E-05 6 1.500E+00 1.920E+00 1.288E+01 0.00E+00 1.28805E+01 3.826E-05 3.826E-05 5.474E-05 7 2.000E+00 1.920E+00 1.718E+01 0.00E+00 1.71828E+01 4.422E-05 4.422E-05 7.302E-05 8 3.000E+00 1.920E+00 2.580E+01 0.00E+00 2.57965E+01 4.847E-05 4.847E-05 1.096E-04 9 4.000E+00 1.920E+00 3.442E+01 0.00E+00 3.44206E+01 4.574E-05 4.574E-05 1.463E-04 10 5.000E+00 1.920E+00 4.305E+01 0.00E+00 4.30536E+01 3.943E-05 3.943E-05 1.830E-04 11 6.000E+00 1.920E+00 5.169E+01 0.00E+00 5.16939E+01 3.194E-05 3.194E-05 2.197E-04 12 7.000E+00 1.920E+00 6.034E+01 0.00E+00 6.03403E+01 2.471E-05 2.471E-05 2.564E-04 13 8.000E+00 1.920E+00 6.899E+01 0.00E+00 6.89919E+01 1.847E-05 1.847E-05 2.932E-04 14 9.000E+00 1.920E+00 7.765E+01 0.00E+00 7.76478E+01 1.342E-05 1.342E-05 3.299E-04 15 1.000E+01 1.920E+00 8.631E+01 0.00E+00 8.63072E+01 9.543E-06 9.543E-06 3.667E-04 16 1.250E+01 1.920E+00 1.080E+02 0.00E+00 1.07968E+02 3.784E-06 3.784E-06 4.588E-04 17 1.500E+01 1.920E+00 1.296E+02 0.00E+00 1.29639E+02 1.396E-06 1.396E-06 5.508E-04 18 1.750E+01 1.920E+00 1.513E+02 0.00E+00 1.51319E+02 4.913E-07 4.913E-07 6.429E-04 19 2.000E+01 1.920E+00 1.730E+02 0.00E+00 1.73002E+02 1.674E-07 1.674E-07 7.350E-04 20 2.500E+01 1.920E+00 2.164E+02 0.00E+00 2.16377E+02 1.825E-08 1.825E-08 9.192E-04 21 3.000E+01 1.920E+00 2.598E+02 0.00E+00 2.59755E+02 1.888E-09 1.888E-09 1.103E-03 22 3.500E+01 1.920E+00 3.031E+02 0.00E+00 3.03136E+02 1.891E-10 1.891E-10 1.287E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.000E+01 8.564E-01 0.00E+00 8.56373E-01 3.569E-06 3.569E-06 3.640E-06 25 2.500E-01 6.000E+01 2.143E+00 0.00E+00 2.14254E+00 8.656E-06 8.656E-06 9.106E-06 26 5.000E-01 6.000E+01 4.290E+00 0.00E+00 4.29038E+00 1.638E-05 1.638E-05 1.823E-05 27 1.000E+00 6.000E+01 8.601E+00 0.00E+00 8.60133E+00 2.882E-05 2.882E-05 3.655E-05 28 1.500E+00 6.000E+01 1.293E+01 0.00E+00 1.29317E+01 3.720E-05 3.720E-05 5.496E-05 29 2.000E+00 6.000E+01 1.728E+01 0.00E+00 1.72805E+01 4.180E-05 4.180E-05 7.344E-05 30 3.000E+00 6.000E+01 2.603E+01 0.00E+00 2.60292E+01 4.199E-05 4.199E-05 1.106E-04 31 4.000E+00 6.000E+01 3.484E+01 0.00E+00 3.48402E+01 3.490E-05 3.490E-05 1.481E-04 32 5.000E+00 6.000E+01 4.371E+01 0.00E+00 4.37071E+01 2.547E-05 2.547E-05 1.857E-04 33 6.000E+00 6.000E+01 5.262E+01 0.00E+00 5.26242E+01 1.682E-05 1.682E-05 2.236E-04 34 7.000E+00 6.000E+01 6.159E+01 0.00E+00 6.15866E+01 1.023E-05 1.023E-05 2.617E-04 35 8.000E+00 6.000E+01 7.059E+01 0.00E+00 7.05898E+01 5.803E-06 5.803E-06 3.000E-04 36 9.000E+00 6.000E+01 7.963E+01 0.00E+00 7.96301E+01 3.095E-06 3.095E-06 3.384E-04 37 1.000E+01 6.000E+01 8.870E+01 0.00E+00 8.87041E+01 1.564E-06 1.564E-06 3.769E-04 38 1.250E+01 6.000E+01 1.115E+02 0.00E+00 1.11517E+02 2.316E-07 2.316E-07 4.738E-04 39 1.500E+01 6.000E+01 1.345E+02 0.00E+00 1.34483E+02 2.695E-08 2.695E-08 5.714E-04 40 1.750E+01 6.000E+01 1.576E+02 0.00E+00 1.57574E+02 2.577E-09 2.577E-09 6.695E-04 41 2.000E+01 6.000E+01 1.808E+02 0.00E+00 1.80769E+02 2.091E-10 2.091E-10 7.680E-04 42 2.500E+01 6.000E+01 2.274E+02 0.00E+00 2.27409E+02 9.239E-13 9.239E-13 9.660E-04 43 3.000E+01 6.000E+01 2.743E+02 0.00E+00 2.74313E+02 2.674E-15 2.674E-15 1.165E-03 44 3.500E+01 6.000E+01 3.214E+02 0.00E+00 3.21428E+02 5.554E-18 5.554E-18 1.365E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 1.920E+00 8.563E-01 3.569E-06 3.639E-06 6.8995E-05 6.9038E-05 6.7703E-05 3 2.500E-01 1.920E+00 2.142E+00 8.656E-06 9.104E-06 6.8995E-05 6.9103E-05 6.5708E-05 4 5.000E-01 1.920E+00 4.287E+00 1.640E-05 1.822E-05 6.8994E-05 6.9211E-05 6.2296E-05 5 1.000E+00 1.920E+00 8.582E+00 2.910E-05 3.647E-05 6.8993E-05 6.9428E-05 5.5400E-05 6 1.500E+00 1.920E+00 1.288E+01 3.826E-05 5.474E-05 6.8991E-05 6.9644E-05 4.8672E-05 7 2.000E+00 1.920E+00 1.718E+01 4.422E-05 7.302E-05 6.8990E-05 6.9861E-05 4.2305E-05 8 3.000E+00 1.920E+00 2.580E+01 4.847E-05 1.096E-04 6.8988E-05 7.0295E-05 3.1077E-05 9 4.000E+00 1.920E+00 3.442E+01 4.574E-05 1.463E-04 6.8985E-05 7.0730E-05 2.2116E-05 10 5.000E+00 1.920E+00 4.305E+01 3.943E-05 1.830E-04 6.8983E-05 7.1165E-05 1.5336E-05 11 6.000E+00 1.920E+00 5.169E+01 3.194E-05 2.197E-04 6.8980E-05 7.1600E-05 1.0410E-05 12 7.000E+00 1.920E+00 6.034E+01 2.471E-05 2.564E-04 6.8978E-05 7.2036E-05 6.9433E-06 13 8.000E+00 1.920E+00 6.899E+01 1.847E-05 2.932E-04 6.8975E-05 7.2472E-05 4.5650E-06 14 9.000E+00 1.920E+00 7.765E+01 1.342E-05 3.299E-04 6.8972E-05 7.2908E-05 2.9661E-06 15 1.000E+01 1.920E+00 8.631E+01 9.543E-06 3.667E-04 6.8970E-05 7.3344E-05 1.9086E-06 16 1.250E+01 1.920E+00 1.080E+02 3.784E-06 4.588E-04 6.8964E-05 7.4436E-05 6.1398E-07 17 1.500E+01 1.920E+00 1.296E+02 1.396E-06 5.508E-04 6.8957E-05 7.5528E-05 1.9144E-07 18 1.750E+01 1.920E+00 1.513E+02 4.913E-07 6.429E-04 6.8951E-05 7.6620E-05 5.8557E-08 19 2.000E+01 1.920E+00 1.730E+02 1.674E-07 7.350E-04 6.8945E-05 7.7712E-05 1.7700E-08 20 2.500E+01 1.920E+00 2.164E+02 1.825E-08 9.192E-04 6.8932E-05 7.9896E-05 1.5863E-09 21 3.000E+01 1.920E+00 2.598E+02 1.888E-09 1.103E-03 6.8919E-05 8.2080E-05 1.4045E-10 22 3.500E+01 1.920E+00 3.031E+02 1.891E-10 1.287E-03 6.8906E-05 8.4264E-05 1.2374E-11 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.000E+01 8.564E-01 3.569E-06 3.640E-06 6.8995E-05 6.9038E-05 6.7702E-05 25 2.500E-01 6.000E+01 2.143E+00 8.656E-06 9.106E-06 6.8995E-05 6.9103E-05 6.5688E-05 26 5.000E-01 6.000E+01 4.290E+00 1.638E-05 1.823E-05 6.8994E-05 6.9211E-05 6.2168E-05 27 1.000E+00 6.000E+01 8.601E+00 2.882E-05 3.655E-05 6.8993E-05 6.9429E-05 5.4734E-05 28 1.500E+00 6.000E+01 1.293E+01 3.720E-05 5.496E-05 6.8991E-05 6.9647E-05 4.7141E-05 29 2.000E+00 6.000E+01 1.728E+01 4.180E-05 7.344E-05 6.8990E-05 6.9866E-05 3.9765E-05 30 3.000E+00 6.000E+01 2.603E+01 4.199E-05 1.106E-04 6.8988E-05 7.0307E-05 2.6690E-05 31 4.000E+00 6.000E+01 3.484E+01 3.490E-05 1.481E-04 6.8985E-05 7.0751E-05 1.6677E-05 32 5.000E+00 6.000E+01 4.371E+01 2.547E-05 1.857E-04 6.8982E-05 7.1198E-05 9.7651E-06 33 6.000E+00 6.000E+01 5.262E+01 1.682E-05 2.236E-04 6.8980E-05 7.1647E-05 5.3901E-06 34 7.000E+00 6.000E+01 6.159E+01 1.023E-05 2.617E-04 6.8977E-05 7.2099E-05 2.8191E-06 35 8.000E+00 6.000E+01 7.059E+01 5.803E-06 3.000E-04 6.8975E-05 7.2553E-05 1.4035E-06 36 9.000E+00 6.000E+01 7.963E+01 3.095E-06 3.384E-04 6.8972E-05 7.3008E-05 6.6780E-07 37 1.000E+01 6.000E+01 8.870E+01 1.564E-06 3.769E-04 6.8969E-05 7.3465E-05 3.0478E-07 38 1.250E+01 6.000E+01 1.115E+02 2.316E-07 4.738E-04 6.8963E-05 7.4615E-05 3.6468E-08 39 1.500E+01 6.000E+01 1.345E+02 2.695E-08 5.714E-04 6.8956E-05 7.5772E-05 3.5736E-09 40 1.750E+01 6.000E+01 1.576E+02 2.577E-09 6.695E-04 6.8949E-05 7.6935E-05 2.9609E-10 41 2.000E+01 6.000E+01 1.808E+02 2.091E-10 7.680E-04 6.8942E-05 7.8103E-05 2.1264E-11 42 2.500E+01 6.000E+01 2.274E+02 9.239E-13 9.660E-04 6.8929E-05 8.0452E-05 7.6941E-14 43 3.000E+01 6.000E+01 2.743E+02 2.674E-15 1.165E-03 6.8915E-05 8.2813E-05 1.9005E-16 44 3.500E+01 6.000E+01 3.214E+02 5.554E-18 1.365E-03 6.8901E-05 8.5185E-05 3.4658E-19 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.1906 (1/Gy), alpha/beta = 3.8948 (Gy), lamda1 = 6.931E+00 (1/h), lamda2 = 2.485E-01 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 5.208E-02 8.405E+01 1.000E-01 1.920E+00 8.898E-01 9.957E-01 9.506E-01 9.8066E-01 9.806628E-01 3 1.302E-01 9.613E+01 2.500E-01 1.920E+00 7.564E-01 9.893E-01 8.898E-01 9.5086E-01 9.508728E-01 4 2.604E-01 9.626E+01 5.000E-01 1.920E+00 5.951E-01 9.788E-01 8.138E-01 8.9999E-01 9.000870E-01 5 5.208E-01 9.652E+01 1.000E+00 1.920E+00 4.047E-01 9.582E-01 7.172E-01 7.9735E-01 7.979480E-01 6 7.812E-01 9.678E+01 1.500E+00 1.920E+00 3.014E-01 9.383E-01 6.573E-01 6.9723E-01 6.988634E-01 7 1.042E+00 9.704E+01 2.000E+00 1.920E+00 2.387E-01 9.190E-01 6.149E-01 6.0241E-01 6.055572E-01 8 1.562E+00 9.756E+01 3.000E+00 1.920E+00 1.676E-01 8.822E-01 5.549E-01 4.3515E-01 4.420871E-01 9 2.083E+00 9.808E+01 4.000E+00 1.920E+00 1.289E-01 8.476E-01 5.110E-01 3.0219E-01 3.126859E-01 10 2.604E+00 9.860E+01 5.000E+00 1.920E+00 1.047E-01 8.151E-01 4.755E-01 2.0273E-01 2.154950E-01 11 3.125E+00 9.912E+01 6.000E+00 1.920E+00 8.807E-02 7.845E-01 4.454E-01 1.3193E-01 1.453851E-01 12 3.646E+00 9.965E+01 7.000E+00 1.920E+00 7.601E-02 7.557E-01 4.191E-01 8.3593E-02 9.638583E-02 13 4.167E+00 1.002E+02 8.000E+00 1.920E+00 6.685E-02 7.285E-01 3.958E-01 5.1738E-02 6.299034E-02 14 4.688E+00 1.007E+02 9.000E+00 1.920E+00 5.966E-02 7.028E-01 3.750E-01 3.1369E-02 4.068319E-02 15 5.208E+00 1.012E+02 1.000E+01 1.920E+00 5.386E-02 6.786E-01 3.561E-01 1.8678E-02 2.602251E-02 16 6.510E+00 1.025E+02 1.250E+01 1.920E+00 4.334E-02 6.236E-01 3.158E-01 4.7860E-03 8.248480E-03 17 7.812E+00 1.038E+02 1.500E+01 1.920E+00 3.625E-02 5.757E-01 2.832E-01 1.1406E-03 2.534749E-03 18 9.115E+00 1.051E+02 1.750E+01 1.920E+00 3.116E-02 5.336E-01 2.563E-01 2.5794E-04 7.642624E-04 19 1.042E+01 1.064E+02 2.000E+01 1.920E+00 2.732E-02 4.966E-01 2.337E-01 5.6160E-05 2.277661E-04 20 1.302E+01 1.090E+02 2.500E+01 1.920E+00 2.191E-02 4.346E-01 1.982E-01 2.4704E-06 1.985501E-05 21 1.562E+01 1.116E+02 3.000E+01 1.920E+00 1.830E-02 3.852E-01 1.716E-01 1.0244E-07 1.711178E-06 22 1.823E+01 1.142E+02 3.500E+01 1.920E+00 1.570E-02 3.451E-01 1.512E-01 4.1186E-09 1.468436E-07 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.667E-03 8.400E+01 1.000E-01 6.000E+01 9.962E-01 9.999E-01 9.963E-01 9.8064E-01 9.806408E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 9.904E-01 9.997E-01 9.909E-01 9.5056E-01 9.505786E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.810E-01 9.993E-01 9.820E-01 8.9813E-01 8.982369E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 9.626E-01 9.986E-01 9.646E-01 7.8760E-01 7.883438E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 9.447E-01 9.979E-01 9.478E-01 6.7475E-01 6.768619E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.272E-01 9.972E-01 9.316E-01 5.6504E-01 5.691598E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 8.938E-01 9.959E-01 9.007E-01 3.7078E-01 3.796218E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 8.622E-01 9.945E-01 8.719E-01 2.2336E-01 2.357095E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 8.323E-01 9.931E-01 8.448E-01 1.2394E-01 1.371549E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 8.040E-01 9.918E-01 8.193E-01 6.3537E-02 7.523158E-02 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 7.772E-01 9.904E-01 7.954E-01 3.0172E-02 3.910107E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 7.517E-01 9.890E-01 7.728E-01 1.3304E-02 1.934466E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 7.276E-01 9.877E-01 7.514E-01 5.4593E-03 9.146965E-03 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 7.047E-01 9.863E-01 7.313E-01 2.0888E-03 4.148586E-03 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 6.522E-01 9.830E-01 6.854E-01 1.4084E-04 4.887550E-04 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 6.059E-01 9.796E-01 6.450E-01 6.3445E-06 4.716333E-05 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 5.647E-01 9.763E-01 6.093E-01 1.9450E-07 3.848612E-06 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 5.281E-01 9.730E-01 5.775E-01 4.1178E-09 2.722554E-07 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 4.661E-01 9.664E-01 5.232E-01 6.3589E-13 9.563631E-10 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 4.158E-01 9.598E-01 4.786E-01 2.5108E-17 2.294972E-12 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 3.745E-01 9.534E-01 4.414E-01 2.6698E-22 4.068587E-15 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 3.502E+00 1.000E-01 9.8066E-01 9.8066E-01 9.8066E-01 3.7506E-01 3.7506E-01 3.7506E-01 3.7506E-01 3 4.005E+00 2.500E-01 9.5087E-01 9.5087E-01 9.5087E-01 3.8640E-01 3.8640E-01 3.8640E-01 3.8640E-01 4 4.011E+00 5.000E-01 9.0009E-01 9.0009E-01 9.0009E-01 4.0653E-01 4.0653E-01 4.0653E-01 4.0653E-01 5 4.022E+00 1.000E+00 7.9795E-01 7.9795E-01 7.9795E-01 4.5025E-01 4.5025E-01 4.5025E-01 4.5025E-01 6 4.033E+00 1.500E+00 6.9886E-01 6.9886E-01 6.9886E-01 4.9715E-01 4.9715E-01 4.9715E-01 4.9715E-01 7 4.043E+00 2.000E+00 6.0556E-01 6.0556E-01 6.0556E-01 5.4577E-01 5.4577E-01 5.4577E-01 5.4577E-01 8 4.065E+00 3.000E+00 4.4209E-01 4.4209E-01 4.4209E-01 6.4269E-01 6.4269E-01 6.4269E-01 6.4269E-01 9 4.087E+00 4.000E+00 3.1269E-01 3.1269E-01 3.1269E-01 7.3148E-01 7.3148E-01 7.3148E-01 7.3148E-01 10 4.109E+00 5.000E+00 2.1550E-01 2.1550E-01 2.1550E-01 8.0614E-01 8.0614E-01 8.0614E-01 8.0614E-01 11 4.130E+00 6.000E+00 1.4539E-01 1.4539E-01 1.4539E-01 8.6469E-01 8.6469E-01 8.6469E-01 8.6469E-01 12 4.152E+00 7.000E+00 9.6386E-02 9.6386E-02 9.6386E-02 9.0811E-01 9.0811E-01 9.0811E-01 9.0811E-01 13 4.174E+00 8.000E+00 6.2990E-02 6.2990E-02 6.2990E-02 9.3895E-01 9.3895E-01 9.3895E-01 9.3895E-01 14 4.195E+00 9.000E+00 4.0683E-02 4.0683E-02 4.0683E-02 9.6013E-01 9.6013E-01 9.6013E-01 9.6013E-01 15 4.217E+00 1.000E+01 2.6023E-02 2.6023E-02 2.6023E-02 9.7431E-01 9.7431E-01 9.7431E-01 9.7431E-01 16 4.271E+00 1.250E+01 8.2485E-03 8.2485E-03 8.2485E-03 9.9179E-01 9.9179E-01 9.9179E-01 9.9179E-01 17 4.326E+00 1.500E+01 2.5347E-03 2.5347E-03 2.5347E-03 9.9747E-01 9.9747E-01 9.9747E-01 9.9747E-01 18 4.380E+00 1.750E+01 7.6426E-04 7.6426E-04 7.6426E-04 9.9924E-01 9.9924E-01 9.9924E-01 9.9924E-01 19 4.434E+00 2.000E+01 2.2777E-04 2.2777E-04 2.2777E-04 9.9977E-01 9.9977E-01 9.9977E-01 9.9977E-01 20 4.543E+00 2.500E+01 1.9855E-05 1.9855E-05 1.9855E-05 9.9998E-01 9.9998E-01 9.9998E-01 9.9998E-01 21 4.651E+00 3.000E+01 1.7112E-06 1.7112E-06 1.7112E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 4.760E+00 3.500E+01 1.4684E-07 1.4684E-07 1.4684E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 3.500E+00 1.000E-01 9.8064E-01 9.8064E-01 9.8064E-01 3.7507E-01 3.7507E-01 3.7507E-01 3.7507E-01 25 4.000E+00 2.500E-01 9.5058E-01 9.5058E-01 9.5058E-01 3.8652E-01 3.8652E-01 3.8652E-01 3.8652E-01 26 4.000E+00 5.000E-01 8.9824E-01 8.9824E-01 8.9824E-01 4.0729E-01 4.0729E-01 4.0729E-01 4.0729E-01 27 4.001E+00 1.000E+00 7.8834E-01 7.8834E-01 7.8834E-01 4.5460E-01 4.5460E-01 4.5460E-01 4.5460E-01 28 4.001E+00 1.500E+00 6.7686E-01 6.7686E-01 6.7686E-01 5.0821E-01 5.0821E-01 5.0821E-01 5.0821E-01 29 4.001E+00 2.000E+00 5.6916E-01 5.6916E-01 5.6916E-01 5.6600E-01 5.6600E-01 5.6600E-01 5.6600E-01 30 4.002E+00 3.000E+00 3.7962E-01 3.7962E-01 3.7962E-01 6.8412E-01 6.8412E-01 6.8412E-01 6.8412E-01 31 4.003E+00 4.000E+00 2.3571E-01 2.3571E-01 2.3571E-01 7.9001E-01 7.9001E-01 7.9001E-01 7.9001E-01 32 4.003E+00 5.000E+00 1.3715E-01 1.3715E-01 1.3715E-01 8.7184E-01 8.7184E-01 8.7184E-01 8.7184E-01 33 4.004E+00 6.000E+00 7.5232E-02 7.5232E-02 7.5232E-02 9.2753E-01 9.2753E-01 9.2753E-01 9.2753E-01 34 4.005E+00 7.000E+00 3.9101E-02 3.9101E-02 3.9101E-02 9.6165E-01 9.6165E-01 9.6165E-01 9.6165E-01 35 4.006E+00 8.000E+00 1.9345E-02 1.9345E-02 1.9345E-02 9.8084E-01 9.8084E-01 9.8084E-01 9.8084E-01 36 4.006E+00 9.000E+00 9.1470E-03 9.1470E-03 9.1470E-03 9.9089E-01 9.9089E-01 9.9089E-01 9.9089E-01 37 4.007E+00 1.000E+01 4.1486E-03 4.1486E-03 4.1486E-03 9.9586E-01 9.9586E-01 9.9586E-01 9.9586E-01 38 4.009E+00 1.250E+01 4.8875E-04 4.8875E-04 4.8875E-04 9.9951E-01 9.9951E-01 9.9951E-01 9.9951E-01 39 4.010E+00 1.500E+01 4.7163E-05 4.7163E-05 4.7163E-05 9.9995E-01 9.9995E-01 9.9995E-01 9.9995E-01 40 4.012E+00 1.750E+01 3.8486E-06 3.8486E-06 3.8486E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 4.014E+00 2.000E+01 2.7226E-07 2.7226E-07 2.7226E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 4.017E+00 2.500E+01 9.5636E-10 9.5636E-10 9.5636E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.021E+00 3.000E+01 2.2950E-12 2.2950E-12 2.2950E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.024E+00 3.500E+01 4.0686E-15 4.0686E-15 4.0686E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 5.208E-02 2.170E-03 0.0000E+00 1.0000E-01 0.0000E+00 1.9200E+00 3 1.302E-01 5.425E-03 0.0000E+00 2.5000E-01 0.0000E+00 1.9200E+00 4 2.604E-01 1.085E-02 0.0000E+00 5.0000E-01 0.0000E+00 1.9200E+00 5 5.208E-01 2.170E-02 0.0000E+00 1.0000E+00 0.0000E+00 1.9200E+00 6 7.812E-01 3.255E-02 0.0000E+00 1.5000E+00 0.0000E+00 1.9200E+00 7 1.042E+00 4.340E-02 0.0000E+00 2.0000E+00 0.0000E+00 1.9200E+00 8 1.562E+00 6.510E-02 0.0000E+00 3.0000E+00 0.0000E+00 1.9200E+00 9 2.083E+00 8.681E-02 0.0000E+00 4.0000E+00 0.0000E+00 1.9200E+00 10 2.604E+00 1.085E-01 0.0000E+00 5.0000E+00 0.0000E+00 1.9200E+00 11 3.125E+00 1.302E-01 0.0000E+00 6.0000E+00 0.0000E+00 1.9200E+00 12 3.646E+00 1.519E-01 0.0000E+00 7.0000E+00 0.0000E+00 1.9200E+00 13 4.167E+00 1.736E-01 0.0000E+00 8.0000E+00 0.0000E+00 1.9200E+00 14 4.688E+00 1.953E-01 0.0000E+00 9.0000E+00 0.0000E+00 1.9200E+00 15 5.208E+00 2.170E-01 0.0000E+00 1.0000E+01 0.0000E+00 1.9200E+00 16 6.510E+00 2.713E-01 0.0000E+00 1.2500E+01 0.0000E+00 1.9200E+00 17 7.812E+00 3.255E-01 0.0000E+00 1.5000E+01 0.0000E+00 1.9200E+00 18 9.115E+00 3.798E-01 0.0000E+00 1.7500E+01 0.0000E+00 1.9200E+00 19 1.042E+01 4.340E-01 0.0000E+00 2.0000E+01 0.0000E+00 1.9200E+00 20 1.302E+01 5.425E-01 0.0000E+00 2.5000E+01 0.0000E+00 1.9200E+00 21 1.562E+01 6.510E-01 0.0000E+00 3.0000E+01 0.0000E+00 1.9200E+00 22 1.823E+01 7.595E-01 0.0000E+00 3.5000E+01 0.0000E+00 1.9200E+00 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.667E-03 6.944E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E+01 25 4.167E-03 1.736E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E+01 26 8.333E-03 3.472E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E+01 27 1.667E-02 6.944E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E+01 28 2.500E-02 1.042E-03 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E+01 29 3.333E-02 1.389E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E+01 30 5.000E-02 2.083E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E+01 31 6.667E-02 2.778E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E+01 32 8.333E-02 3.472E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E+01 33 1.000E-01 4.167E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E+01 34 1.167E-01 4.861E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E+01 35 1.333E-01 5.556E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E+01 36 1.500E-01 6.250E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E+01 37 1.667E-01 6.944E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E+01 38 2.083E-01 8.681E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E+01 39 2.500E-01 1.042E-02 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E+01 40 2.917E-01 1.215E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E+01 41 3.333E-01 1.389E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E+01 42 4.167E-01 1.736E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E+01 43 5.000E-01 2.083E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E+01 44 5.833E-01 2.431E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 8.06667E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 08:30:41 PM