SISMID 2017 Module 16 on Evaluating Vaccine Efficacy

Instructors: Peter Gilbert, Dean Follmann, Erin Gabriel, Michael Sachs

Session 1 Slides on Introduction to Study Designs for Evaluating Vaccine Efficacy (Elizabeth Halloran)

• Introduction to VE Study Designs: Session 1

Session 2 Slides on Introduction to Vaccination Assays and Immune Response

• Introduction to Vaccination Assays and Immune Response: Session 2

Session 3 Slides on Introduction to Frameworks for Assessing Surrogate Endpoints/Immunological Correlates of VE

• Introduction to Frameworks for Evaluating Surrogate Endpoints: Session 3

Session 4 Slides on Additional Study Designs for Evaluating VE

• Additional Study Designs for Evaluating VE: Session 4

Session 5 Slides on Methods for Assessing Immunological Correlates of Risk and Optimal Surrogate Endpoints

• Evaluating Correlates of Risk and Optimal Surrogates: Session 5

Session 6 Slides on Effect Modifier Methods for Assessing Immunological Correlates of VE (Part I)

• Effect Modifier Methods for Correlates of VE- Part I: Session 6

Session 7 Slides on Effect Modifier Methods for Assessing Immunological Correlates of VE (Part II)

• Effect Modifier Methods for Correlates of VE- Part II: Session 7

Session 8 Slides on Tutorial for the R Package pseval for Effect Modifier Methods for Assessing Immunological Correlates of VE

• Tutorial for R Package pseval: Session 8
• Slides on the R Package pseval: Session 8

Session 9 Slides on Introduction to Sieve Analysis of Pathogen Sequences, for Assessing How VE Depends on Pathogen Genomics

• Introduction to Sieve Analysis: Session 9- Part I
• Introduction to Sieve Analysis: Session 9- Part II

Session 10 Slides on Methods for VE and Sieve Analysis Accounting for Multiple Founders

• Introduction to Sieve Analysis for Multiple Founders: Session 10

References for Statistical Methods for Assessing Correlates of Vaccine Protection

• Selected Published Papers

Data Set

• HIV Vaccine Efficacy Trial Dataset
• Dataset Documentation

Computer Code

• R code implementing cch Borgan estimator II, Breslow et al. (2009, AJE), and Gilbert and Hudgens (2008, Biometrics)