{"id":740,"date":"2018-10-18T23:49:41","date_gmt":"2018-10-19T06:49:41","guid":{"rendered":"http:\/\/faculty.washington.edu\/libinxu\/?p=740"},"modified":"2018-11-02T23:00:28","modified_gmt":"2018-11-03T06:00:28","slug":"our-collaborative-work-on-smoothened-activating-cilia-oxysterols-is-published-in-molecular-cell","status":"publish","type":"post","link":"https:\/\/faculty.washington.edu\/libinxu\/2018\/10\/18\/our-collaborative-work-on-smoothened-activating-cilia-oxysterols-is-published-in-molecular-cell\/","title":{"rendered":"Our collaborative work on Smoothened-activating cilia oxysterols was published in Molecular Cell!"},"content":{"rendered":"<p>This work reported cilia-associated oxysterols can activate Hedgehog signaling through Smoothened and inhibition of the formation of such oxysterols can impede Hedgehog pathway activation. This is a multi-institutional collaboration led by David Raleigh and Jeremy Reiter at UCSF. Good job by Kelly on the oxysterol analysis in this work! Check out the <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1097276518306944?dgcid=author\" target=\"_blank\" rel=\"noopener\">paper here<\/a> and the <a href=\"https:\/\/www.cell.com\/molecular-cell\/current\" target=\"_blank\" rel=\"noopener\">Cover Art of the issue<\/a> illustrating findings in this paper.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2018\/10\/TOC_CiliaOxy.jpg\"><img loading=\"lazy\" class=\"alignnone wp-image-741\" src=\"https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2018\/10\/TOC_CiliaOxy-300x300.jpg\" alt=\"\" width=\"231\" height=\"231\" srcset=\"https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2018\/10\/TOC_CiliaOxy-300x300.jpg 300w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2018\/10\/TOC_CiliaOxy-150x150.jpg 150w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2018\/10\/TOC_CiliaOxy-768x766.jpg 768w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2018\/10\/TOC_CiliaOxy-1024x1022.jpg 1024w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2018\/10\/TOC_CiliaOxy-624x622.jpg 624w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2018\/10\/TOC_CiliaOxy.jpg 1235w\" sizes=\"(max-width: 231px) 100vw, 231px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This work reported cilia-associated oxysterols can activate Hedgehog signaling through Smoothened and inhibition of the formation of such oxysterols can impede Hedgehog pathway activation. This is a multi-institutional collaboration led by David Raleigh and Jeremy Reiter at UCSF. Good job by Kelly on the oxysterol analysis in this work! Check out the paper here and [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[],"_links":{"self":[{"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/posts\/740"}],"collection":[{"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/comments?post=740"}],"version-history":[{"count":2,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/posts\/740\/revisions"}],"predecessor-version":[{"id":759,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/posts\/740\/revisions\/759"}],"wp:attachment":[{"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/media?parent=740"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/categories?post=740"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/tags?post=740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}