{"id":1549,"date":"2024-01-29T00:22:00","date_gmt":"2024-01-29T08:22:00","guid":{"rendered":"https:\/\/faculty.washington.edu\/libinxu\/?p=1549"},"modified":"2024-04-04T00:23:37","modified_gmt":"2024-04-04T07:23:37","slug":"our-collaborative-paper-with-the-wang-lab-on-the-transport-of-benzalkonium-chlorides-bacs-by-octs-and-hmates-was-published-in-drug-metabolism-and-disposition","status":"publish","type":"post","link":"https:\/\/faculty.washington.edu\/libinxu\/2024\/01\/29\/our-collaborative-paper-with-the-wang-lab-on-the-transport-of-benzalkonium-chlorides-bacs-by-octs-and-hmates-was-published-in-drug-metabolism-and-disposition\/","title":{"rendered":"Our collaborative paper with the Wang Lab on the transport of benzalkonium chlorides (BACs) by OCTs and hMATEs was published in Drug Metabolism and Disposition!"},"content":{"rendered":"\n<p>Congratulations to Dr. Vieira in the Joanne Wang&#8217;s Lab in the Department of Pharmaceutics and Dr. Ryan Seguin in our lab! We found that short-chain (C8 and C10) BACs are substrates of OCTs and hMATES while all BACs are inhibitors of these transporters using metformin as the probe substrate. Check out the paper <a href=\"https:\/\/dmd.aspetjournals.org\/content\/52\/4\/312\" target=\"_blank\" rel=\"noreferrer noopener\">here<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2024\/04\/BAC-transport-scaled.jpg\"><img loading=\"lazy\" width=\"1024\" height=\"300\" src=\"https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2024\/04\/BAC-transport-1024x300.jpg\" alt=\"\" class=\"wp-image-1547\" srcset=\"https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2024\/04\/BAC-transport-1024x300.jpg 1024w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2024\/04\/BAC-transport-300x88.jpg 300w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2024\/04\/BAC-transport-768x225.jpg 768w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2024\/04\/BAC-transport-1536x450.jpg 1536w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2024\/04\/BAC-transport-2048x600.jpg 2048w, https:\/\/faculty.washington.edu\/libinxu\/wordpress\/wp-content\/uploads\/2024\/04\/BAC-transport-624x183.jpg 624w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to Dr. Vieira in the Joanne Wang&#8217;s Lab in the Department of Pharmaceutics and Dr. Ryan Seguin in our lab! We found that short-chain (C8 and C10) BACs are substrates of OCTs and hMATES while all BACs are inhibitors of these transporters using metformin as the probe substrate. Check out the paper here.<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[],"_links":{"self":[{"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/posts\/1549"}],"collection":[{"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/comments?post=1549"}],"version-history":[{"count":1,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/posts\/1549\/revisions"}],"predecessor-version":[{"id":1550,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/posts\/1549\/revisions\/1550"}],"wp:attachment":[{"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/media?parent=1549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/categories?post=1549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/faculty.washington.edu\/libinxu\/wp-json\/wp\/v2\/tags?post=1549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}