2023
2024
Bailey L.R.J, Bugg D., Reichardt I.M., Ortaç C.D., Nagle A., Gunaje J., Martinson A., Johnson R., MacCoss M.J., Sakamoto T., Kelly D.P., Regnier M., Davis J. (2024). MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States. Circulation. Jun 4;149(23):1812-1829. https://doi.org/10.1161/circulationaha.123.066860
Bugg D., Davis J. Sox9-coordinated cellular neighborhoods generate fibrosis. (2024). Cell Stem Cell. 2;31(5):589-590.
2023
Bretherton, R.C., Reichardt, I.M., Zabrecky, K.A., Goldstein, A.J., Bailey, L.R.J., Bugg, D., McMillen, T.S., Kooiker, K.B., Flint, G.V., Martinson, A., Gunaje, J., Kozer, F., Plaster, E., Linke, W.A., Regnier, M., Moussavi-Harami, F., Sniadecki, N.J., DeForest, C.A., Davis, J. (2023). Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency. Biorxiv Preprint
Cai S., Zhao M., Zhou B., Yoshii A., Bugg D., Villet O., Sahu A., Olson G.S., Davis J., Tian R. (2023). Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction. J Clin Invest. 15;133(4):e159498. https://doi.org/10.1172/jci159498
Bretherton R.C., Haack A.J., Kopyeva I., Rahman F., Kern J.D., Bugg D., Theberge A.B., Davis J., DeForest C.A. (2023). User-Controlled 4D Biomaterial Degradation with Substrate-Selective Sortase Transpeptidases for Single-Cell Biology. Adv Mater. 35(19):e2209904. https://doi.org/10.1002/adma.202209904
Nelson A.R., Bugg D., Davis J., Saucerman J.J. (2023). Network model integrated with multi-omic data predicts MBNL1 signals that drive myofibroblast activation. iScience. 26(4):106502. https://doi.org/10.1016/j.isci.2023.106502
2022
Bugg, D., Bailey, L.R.J., Bretherton, R.C., Beach, K.E., Reichardt, I.M., Robeson, K.Z., Reese, A.C., Gunaje, J., Flint, G., DeForest, C.A., Stempien-Otero, A., Davis, J. (2022). MBNL1 drives dynamic transitions between fibroblasts and myofibroblasts in cardiac wound healing. Cell Stem Cell, 29(3), 419-433 https://doi.org/10.1016/j.stem.2022.01.012
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Bailey, L.R.J. & Davis, J. (2022). If these myocytes could talk, they would speak the language of metabolites. Journal of Clinical Investigation. https://doi.org/10.1172/JCI156296
Ngwenyama N., Kaur K., Bugg D., Theall B., Aronovitz M., Berland R., Panagiotidou S., Genco C., Perrin M.A., Davis J., Alcaide P. (2022). Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction. Nat Cardiovasc Res. 1(8):761-774. https://doi.org/10.1038/s44161-022-00116-7
2021
Mijailovich, S.M., Prodanovic, M., Poggesi, C., Powers, J.D., Davis, J., Geeves, M.A., Regnier, M. (2021). The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions. Journal of Molecular and Cellular Cardiology, (155) 112-124 https://doi.org/10.1016/j.yjmcc.2021.02.009
Reichardt, I.M., Robeson, K.Z., Regnier, M., Davis, J.M. (2021). Controlling cardiac fibrosis through cardiac fibroblast state space modulation. Cellular Signaling, (79) 109888 https://doi.org/10.1016/j.cellsig.2020.109888
El-Nachef, D., Bugg, D., Beussman, K., Martinson, A., Murry, C., Sniadecki, N., & Davis, J. (2021). Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion In Vivo. Circulation, (143), 1635-1638. https://doi.org/10.1161/CIRCULATIONAHA.119.044974
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2020
Powers, J. D., Kooiker, K. B., Mason, A. B., Teitgen, A. E., Flint, G. V., Tardiff, J. C., Davis, J.M., Moussavi-Harami, F. (2020). Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts. JCI Insight. https://doi.org/10.1172/jci.insight.142446
Bugg, D.*, Bretherton, R. C.*, Kim, P.*, Olszewski, E., Nagle, A., Schumacher, A. E., Chu, N., Gunaje, J., DeForest, C. A., Stevens, K., Kim, D.H., Davis, J. M. (2020). Infarct Collagen Topography Regulates Fibroblast Fate Via p38-Yap-TEAD Signals. Circulation Research, (127) 1306-1322 https://doi.org/10.1161/CIRCRESAHA.119.316162
Bretherton, R.*, Bugg, D.*, Olszewski, E.*, & Davis, J. (2020). Regulators of cardiac fibroblast cell state. Matrix Biology. (91-92) 117-135 https://doi.org/10.1016/j.matbio.2020.04.002
Mandrycky, C. J., Williams, N. P., Batalov, I., El-Nachef, D., de Bakker, B. S., Davis, J., … Sniadecki, N. J. (2020). Engineering Heart Morphogenesis. Trends in Biotechnology. 38(8) 835-845 https://doi.org/10.1016/j.tibtech.2020.01.006
Brady, E.L., Kirby, M.A., Olszewski, E., Grosjean, P., Johansson, F., Davis, J., Wang, R.K., Stevens, K.R. (2020). Guided vascularization in the rat heart leads to transient vessel patterning. APL Bioengineering, (4) 016105. https://doi.org/10.1063/1.5122804
El-Nachef, D., Shi, K., Beussman, K. M., Martinez, R., Regier, M. C., Everett, G. W., … Davis, J. (2020). A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives. Stem Cell Reports, 15(1), 226–241. https://doi.org/10.1016/j.stemcr.2020.06.005
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Earlier Publications
Reiger, M.C., Olszewski, E., Carter, C., Aitchison, J.D., Kaushansky, A., Davis, J., Berthier, E., Beebe, D.J., Stevens, K.R. (2019) Spatial presentation of biological molecules to cells by localized diffusive transfer. Lab on a Chip, 19 2114-2126. https://doi.org/10.1039/C9LC00122K
Kwong, J.Q., Huo, J., Bround, M.J., Boyer, J.G., Shwanekamp, J.A., Ghazal, N., Maxwell, J.T., Jang, Y.C., Khuchua, Z., Shi, K., Bers, D.M., Davis, J., Molkentin, J.D. (2018). The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI Insight, 3(22). https://doi.org/10.1172/jci.insight.121689
Liu, L., Shadish, J. A., Arakawa, C. K., Shi, K., Davis, J., & DeForest, C. A. (2018). Cyclic Stiffness Modulation of Cell‐Laden Protein–Polymer Hydrogels in Response to User‐Specified Stimuli Including Light. Advanced Biosystems, 2(12), 1800240. https://doi.org/10.1002/adbi.201800240
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Molkentin, J. D., Bugg, D., Ghearing, N., Dorn, L. E., Kim, P., Sargent, M. A., … Davis, J. (2017). Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis. Circulation, 136(6), 549–561. https://doi.org/10.1161/CIRCULATIONAHA.116.026238
Vanhoutte, D., Schips, T.G., Kwong, J.Q., Davis, J., … McNally, E.M., Molkentin, J.D. (2016) Thrombospondin expression in myofibers stabilizes muscle membranes. Elife. https://doi.org/10.7554/elife.17589
Stempien-Otero, A., Kim, D.-H., & Davis, J. (2016). Molecular networks underlying myofibroblast fate and fibrosis. Journal of Molecular and Cellular Cardiology, 97, 153–161. https://doi.org/10.1016/J.YJMCC.2016.05.002
Davis, J., Davis, L. C., Correll, R. N., Makarewich, C. A., Schwanekamp, J. A., Moussavi-Harami, F., … Molkentin, J. D. (2016). A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell, 165(5), 1147–1159. https://doi.org/10.1016/J.CELL.2016.04.002
Highlighted in Cell, Nature Reviews Cardiology, and Trends in Molecular Medicine and featured in Medical News Today
Davis, J., Salomonis, N., Ghearing, N., Lin, S.-C. J., Kwong, J. Q., Mohan, A., … Molkentin, J. D. (2015). MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response. Nature Communications, 6(1), 10084. https://doi.org/10.1038/ncomms10084
Davis, J., & Molkentin, J. D. (2014). Myofibroblasts: trust your heart and let fate decide. Journal of Molecular and Cellular Cardiology, 70, 9–18. https://doi.org/10.1016/j.yjmcc.2013.10.019
Goonasekera, S.A.*, Davis, J.*, … , Molkentin, J.D. (2014). Enhanced Ca2+ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Human Molecular Genetics, 23(14), 3706-3715. https://doi.org/10.1093/hmg/ddu079
Wang W., Barnabei M.S., Asp M.L., Heinis F.I., Arden E., Davis J., Braunlin E., Li Q., Davis J.P., Potter J.D., Metzger J.M. (2013). Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance. Nature Medicine, 19(3):305-12. https://doi.org/10.1038/nm.3079
Davis J, Kwong JQ, Kitsis RN, Molkentin JD. (2013). Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle. PLoS One. 8(12):e82053. https://doi.org/10.1371/journal.pone.0082053
Davis, J., Burr, A. R., Davis, G. F., Birnbaumer, L., & Molkentin, J. D. (2012). A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo. Developmental Cell, 23(4), 705–715. https://doi.org/10.1016/j.devcel.2012.08.017
Davis, J., Maillet, M., Miano, J. M., & Molkentin, J. D. (2012). Lost in Transgenesis. Circulation Research, 111(6), 761–777. https://doi.org/10.1161/CIRCRESAHA.111.262717
Kehat I., Davis J., Tiburcy M., Accornero F., Saba-El-Leil M.K., Maillet M., York A.J., Lorenz J.N., Zimmermann W.H., Meloche S., Molkentin J.D. (2011) Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circulation Research, 108(2), 176-183. https://doi.org/10.1161/circresaha.110.231514