My goal is to understand the mechanisms of plasticity in the human brain by linking changes in function to changes in neuroanatomical structure, with a particular focus on the effects of early sensory loss and prosthetic vision. My work can be roughly divided into three inter-related areas of research (I’ve provided recent example papers for each research direction).<\/p>\n\n\n\n

If humans become blind early in life, they only regain very limited ability to make use of that sense if it is ever restored in adulthood.<\/p>\n\n\n\n

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• Fine I, Wade AR, Brewer AA, May MG, Goodman DF, Boynton GM, Wandell BA, MacLeod DI. Long-term deprivation affects visual perception and cortex. Nat Neurosci 2003;6:915-916. Recommended by Faculty of 1000.<\/em><\/li>\n\n\n\n
• Huber, E., Webster, J, Brewer, A., MacLeod, D.I., Wandell, B, Boynton, G.M., Wade, A., Fine, I.<\/strong> A Lack of Experience-Dependent Plasticity after More than a Decade of Recovered Sight. Psychological Science. 2015; 26(4):393-401.<\/em><\/li>\n<\/ul>\n\n\n\n

  There is also \u201ccross-modal plasticity\u201d – colonization of the brain regions that normally serve the missing sense by remaining senses.<\/p>\n\n\n\n

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  • Fine, I. & Park, W. J. Do you hear what I see? How do early blind individuals experience object motion? Philosophical Transactions of the Royal Society B, 2023, 378, 20210460<\/em><\/li>\n\n\n\n
  • Park WJ,\u00a0Fine I. <\/strong>The perception of auditory motion in sighted and early blind individuals. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2310156120. doi: 10.1073\/pnas.2310156120. Epub 2023 Nov 28.PMID:\u00a038015842<\/em><\/li>\n<\/ul>\n\n\n\n

    This plasticity has implications for the ability to restore sight using retinal prosthetics. <\/p>\n\n\n\n

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    • Esquenazi RB, Meier K, Beyeler M, Boynton GM, Fine I.<\/strong> Learning to see again: Perceptual learning of simulated abnormal on- off-cell population responses in sighted individuals. J Vis. 2021 Dec 1;21(13):10. doi: 10.1167\/jov.21.13.10.<\/em><\/li>\n\n\n\n
    • Fine, I., Boynton, G.M., Pulse trains to percepts: A virtual patient describing the perceptual effects of human visual cortical stimulation. Scientific Reports, 2024 Jul 29;14(1):17400.<\/em><\/li>\n<\/ul>\n\n\n\n

      I work in close collaboration with other PIs, for more information see the VisCog<\/a> website. For information about human neuroscience at UW go to the CHN website<\/a>.<\/p>\n\n\n\n

      For videos on sight recovery individual MM go here<\/a> (you’ll need to ask for permission and wait for me to grant access).
      <\/p>\n\n\n\n

      A reasonably recent CV<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

      My goal is to understand the mechanisms of plasticity in the human brain by linking changes in function to changes in neuroanatomical structure, with a particular focus on the effects of early sensory loss and prosthetic vision. My work can be roughly divided into three inter-related areas of research (I’ve provided recent example papers for … Continue reading “Welcome to FineLab”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-260","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/faculty.washington.edu\/ionefine\/wp-json\/wp\/v2\/pages\/260"}],"collection":[{"href":"https:\/\/faculty.washington.edu\/ionefine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/faculty.washington.edu\/ionefine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.washington.edu\/ionefine\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.washington.edu\/ionefine\/wp-json\/wp\/v2\/comments?post=260"}],"version-history":[{"count":11,"href":"https:\/\/faculty.washington.edu\/ionefine\/wp-json\/wp\/v2\/pages\/260\/revisions"}],"predecessor-version":[{"id":373,"href":"https:\/\/faculty.washington.edu\/ionefine\/wp-json\/wp\/v2\/pages\/260\/revisions\/373"}],"wp:attachment":[{"href":"https:\/\/faculty.washington.edu\/ionefine\/wp-json\/wp\/v2\/media?parent=260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}