Paul Yager
Department of Bioengineering, Box 355061, University of Washington, Seattle, WA 98195, USA
CURRICULUM VITAE

yagerp@u.washington.edu

FAX: (206) 616-3928 Assistant: 206-543-8063


EMPLOYMENT:


EDUCATIONAL INSTITUTION, DEGREE, YEARS

Princeton University

A. B., Biochemistry, 1975

University of Oregon

Ph.D., Chemistry, 1980


HONORS:


ISSUED PATENTS


PUBLICATIONS:

1. Polarized resonance Raman spectroscopy of beta-carotene in phospholipid monolayers, Yager, P., B.A. Thesis, Department of Biochemistry, Princeton University (1975)

2. A novel mechanism for the Na-K ATPase, Yager, P., J. Theor. Biol., 66, 1-11 (1977)

3. Interpretation of biomembrane structure by Raman difference spectroscopy, Gaber, B.P., Yager, P. and Peticolas, W.L., Biophysical Journal, 21, 161-207 (1978)

4. Deuterated phospholipids as non-perturbing components for Raman studies of biomembranes, Gaber, B.P., Yager, P. and Peticolas, W.L., Biophysical Journal, 22, 191-207 (1978)

5. Conformational non-equivalence of chains 1 and 2 of dipalmitoyl phosphatidylcholine as observed by Raman spectroscopy, Gaber, B.P., Yager, P. and Peticolas, W.L., Biophysical Journal, 24, 677-688 (1978)

6. Applications of Raman spectroscopy to biomembrane structure, Gaber, B.P., Yager, P. and Peticolas, W.L., pp. 241-260 in Infrared and Raman Spectroscopy of Biological Molecules, T.M. Theophanides, ed., D. Reidel Pub. Co., Holland (1979)

7. Statistical mechanical analysis of Raman spectroscopic order parameter changes in pressure-induced lipid bilayer phase transitions, Yager, P. and Peticolas, W.L., Biophysical Journal, 31, 359-370 (1980)

8. Raman spectroscopic studies of the structure of phases of aqueous phosphatidylcholine dispersions and the kinetics of conversions between them, Yager, P., Ph.D. Dissertation, Department of Chemistry, University of Oregon, June, 1980

9. Thermodynamic properties of mixtures of deuterated and undeuterated dipalmitoyl phosphatidylcholines, Klump, H.H., Gaber, B.P., Peticolas, W.L., and Yager, P., Thermochimica Acta, 48, 361-366 (1981)

10. The kinetics of the main phase transitions of aqueous dispersions of phospholipids induced by pressure jump and monitored by Raman spectroscopy, Yager, P. and Peticolas, W.L., Biochimica et Biophysica Acta, 688, 775-785 (1982)

11. Changes in size and shape of liposomes undergoing chain melting transitions as studied by optical microscopy, Yager, P., Sheridan, J.P., and Peticolas, W.L., Biochimica et Biophysica Acta, 693, 484-491 (1982)

12. Destabilization of lipid non-bilayer phase by high pressure, Yager, P. and Chang, E.L. Biochimica et Biophysica Acta, 731, 491-494 (1983)

13. Encapsulation of hemoglobin in phospholipid vesicles, Gaber, B.P., Yager, P., Sheridan, J.P. and Chang, E.L., FEBS Letters, 153, 285-288 (1983)

14. Effect of high pressure on a lipid non-bilayer phase, Chang, E.L. and Yager, P., Molecular Crystals and Liquid Crystals, 98, 125-129 (1983)

15. The secondary structure of acetylcholine receptor reconstituted in a single lipid component as determined by Raman spectroscopy, Yager, P., Chang, E.L., Williams, R.W. and Dalziel, A.W., Biophysical Journal, 45, 26-28 (1984)

16. Formation of tubules by a polymerizable surfactant, Yager, P. and Schoen, P.E., Molecular Crystals and Liquid Crystals, 106, 371-381 (1984)

17. Spectroscopic studies of polymerized surfactants: 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine, Schoen, P.E. and Yager, P., Journal of Polymer Science, Polymer Physics Edition, 23, 2203-2216 (1985)

18. Structure of lipid tubules formed from a polymerizable lecithin, Yager, P., Schoen, P.E., Davies, C., Price, R., and Singh, A., Biophysical Journal, 48, 899-906 (1985)

19. Spectroscopic studies of a diacetylenic surfactant, Schoen, P.E., Yager, P. and Priest, R.G., in Polydiacetylenes: Synthesis, Structure, and Electronic Properties, Bloor, D. and Chance, R.R., Eds.., NATO Advance Study Institute Series, Martinus Nijhoff, Dordrecht, the Netherlands (1985)

20. Tubule formation by heterobifunctional polymerizable lipids: synthesis and characterization, Singh, A., Price, R., Schnur, J.M., Schoen, P.E., and Yager, P., Polym. Preprints, 27:393-394 (1986)

21. Functional reconstitution of a membrane protein in a diacetylenic polymerizable lecithin, Yager, P., Biosensors, 2, 363-373 (1986)

22. Membranes, Yager, P. and Gaber, B.P., in Biological Applications of Raman Spectroscopy: Vol. 1--Raman Spectra and The Conformations of Biological Macromolecules, Spiro, T.G., ed., John Wiley, New York. pp. 203-261 (1987).

23. Orientation of lipid tubules by a magnetic field, Rosenblatt, C., Yager, P., and Schoen, P.E., Biophys. J., 52, 295-301 (1987)

24. Helical and tubular microstructures formed by polymerizable phosphatidylcholines, Georger, J., Price, R., Singh, A., Schnur, J.M., Schoen, P.E. and Yager, P., J. Am. Chem. Soc. 109, 6169-6175 (1987).

25. Progress report on the fabrication of an acetylcholine receptor-based biosensor, Dalziel, A.W., Georger, J., Price, R.R., Singh, A., and Yager, P., in The Proceedings of the Membrane Protein Symposium, S.G. Goheen, Ed., BioRad Laboratories , Richmond CA, (1987)

26. Synthesis and characterization of positional isomers of 1,2-bis heptacosadiynoyl phosphocholines, Singh, A., Singh, B.P., Gaber, B.P., Burke, T., Yager, P., Schoen, P.E. and Schnur, J.M., pp. 467-476 in Surfactants in Solution, L.K. Mittal, Ed., New York, (1987)

27. Order in diacetylenic microstructures, Schoen, P.E., Yager, P., Sheridan, J.P., Price, R.R., Schnur, J.M., Singh, A., Rhodes, D.G. and Blechner, S.L., Mol. Cryst. Liq. Cryst., 153, 357-366 (1987)

28. Lipid-based tubule microstructures, Schnur, J.M, Price, R, Schoen, P.E., Yager, P., Calvert, J.M., Georger, J., and Singh, A., Thin Solid Films, 152, 181-206 (1987).

29. The mechanism of formation of tubules from liposomes, Yager, P., Schoen, P.E., Price, R., Schnur, J.M., Singh, A., and Rhodes, D.G., Chem. Phys. Lipids., 46, 171-179 (1988).

30. Light scattering investigation of electric field alignment of phospholipid tubules, Li, Z., Rosenblatt, C., Yager, P., and Schoen, P.E., Biophys. J., 54, 289-294 (1988).

31. Development of membrane-based biosensors: measurement of current from photocycling bacteriorhodopsin on patch clamp electrodes, Yager, P., in Biotechnological Applications of Lipid Microstructures, Volume 238, B.P. Gaber, ed., Plenum, Inc., (1988)

32. Lateral phase separation based on chirality in a polymerizable lipid and its influence on formation of tubular microstructures, Singh, A., Georger, J., Price, R.R., Burke, T., Schoen, P.E., and Yager, P., Chem. Phys. Lipids, 47, 135-148 (1988).

33. Fabrication of key components of a receptor-based biosensor, Ligler, F.S., Fare, T.L., Seib, E.E., Smuda, J.W., Singh, A., Ahl, P. , Ayers, M.E., Dalziel, A.W., and Yager, P., Med. Instrumentation, 22, 247-256 (1988).

34. Structure of polymerizable lipid bilayers, I -- 1,2-bis(10,12-tricosadiynoyl)-sn-phosphocholine, a tubule-forming phosphatidylcholine, Rhodes, D.G., Blechner, S.L., Yager, P. Schoen, P.E., Chem. Phys. Lipids, 49, 39-47 (1988)

35. Entrapment of 6-carboxyfluorescein within cylindrical phospholipid microstructures, Burke, T.G., Singh, A., and Yager, P., Ann. N.Y. Acad. Sci., 507, 330-333 (1988)

36. Electric field manipulation of phospholipid tubules: Optical birefringence measurements, Woods, D.M., Li, Z., Rosenblatt, C., Yager, P., and Schoen, P.E., Mol. Cryst. Liq. Cryst., 167, 1-6 (1989)

37. An optical method for detecting anesthetics and other lipid-soluble compounds, Merlo, S., Burgess, L.W., and Yager, P., Sensors and Actuators, A21-A23, 1150-1154 (1990)

38. Optical method for monitoring the concentration of general anesthetics and other small organic molecules--an example of phase transition sensing, Merlo, S. and Yager, P., Anal. Chem., 62, 2728-2735 (1990)

39. Electrostatic interactions within helical structures of chiral lipid bilayers, Chappell, J.S. and Yager, P., Chemical Physics, 150, 73-79 (1991).

40. Sensore a fibre ottiche per il monitoraggio dell'anestesia generale, Merlo, S., Yager, P., and Burgess, L.W., in Proceedings of Fotonica '91, 2° Cenvegno Nazionale Sull Techniche Fotoniche per L'Informazione, Simione, Italy, March 1991 (1991)

41. A model for crystalline order within helical and tubular structures of chiral bilayers, Chappell, J.S., and Yager, P., Chem. Phys. Lipids, 58, 253-258 (1991).

42. Electrolyte effects on bilayer tubule formation by a diacetylenic phospholipid, Chappell, J.S., and Yager, P., Biophysical Journal, 60, 1-14 (1991)

43. Structure of polymerizable lipid bilayers III: two heptacosadiynoyl phosphatidylcholine isomers, Blechner, S.L., Morris, W., Schoen, P.E., Yager, P., Singh, A. and Rhodes, D.G., Chem. Phys. Lipids, 58, 41-54.(1991)

44. Development of a fiber optic sensor for detection of general anesthetics and other small organic molecules, Merlo, S., Yager, P. and Burgess, L.W., in Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis: David Z D'Argenio, ed., Plenum Press, New York (1991)

45. Detection of general anesthetics using a fluorescence-based sensor: incorporation of a single-fiber approach, Abrams, S.B., Fleharty, H.L., and Yager, P., SPIE Proceedings 1420, 13-21, (1991)

46. Preparation and properties of macroporous poly(n-isopropylacrylamide) hydrogels, Wu, X.S., Hoffman, A.S., and Yager, P., Polymer Preprints 32(3), 463-464, (1991).

47. When lipid bilayers won't form liposomes: tubules, helices, and cochleate cylinders, Yager, P., Chappell, J, and Archibald, D.D., in Membrane Structure and Function: The State of the Art--Proceedings of the Indo-U.S. Workshop, Gaber, B.P. and Easwaran, K.R.K., Eds., pp. 1-19, Adenine Press, (1992)

48. Formation of mineral microstructures with a high aspect ratio from phospholipid bilayers, Chappell, J.S., and Yager, P., J. Mat. Sci. Lett., 11, 633-636, (1992).

49. Microstructural polymorphism in bovine brain galactocerebrosides and its subfractions, Archibald, D.D., and Yager, P., Biochemistry, 31, 9045-9055 (1992)

50. Detection of volatile and soluble general anesthetics using a fluorescence-based fiber optic sensor: Recent progress in chemical sensitivity and noise sources, Yager, P. and Abrams, S.B., SPIE Proceedings, 1648, 51-62 (1992)

51. Evaluation of signal reabsorption and sample heating in NIR-Raman measurements, Archibald, D.D., and Yager, P., Applied Spectroscopy, 46, 1613-1620 (1992)

52. Conjugation of phosphatidylethanolamine to poly-(N-isopropylacrylamide) for potential use in liposomal drug delivery systems, Wu, X.S., Hoffman, A.S., and Yager, P., Polymer, 33(21), 4659-4662 (1992).

53. Synthesis and characterization of thermally reversible macroporous poly(N-isopropylacrylamide) hydrogels, Wu, X.S., Hoffman, A.S., and Yager, P., J. Polym. Sci.: Pt. A.: Polym. Chem., 30, 2121-2129 (1992).

54. Perturbation of the chain melting transition of DPPC by galactose, agarose and Laurdan as determined by differential scanning calorimetry, Abrams, S.B. and Yager, P., Biochim. Biophys. Acta, 1146, 127-135 (1993)

55. Synthesis of and insulin release from erodible poly(N-isopropylacrylamide)-phospholipid composites, Wu, X.S., Hoffman, A.S., and Yager, P., J. Intell. Mtls. Syst. & Struct., 4, 202-209 (1993)

56. Influence of pH on the precursors of phospholipid tubules in methanolic solution, Lu, M.-H., Rosenblatt, C., and Yager, P., Chem. Phys. Lipids, 65, 77-84 (1993)

57. Use of a visible fluorescence dye in a fiberoptic sensor to detect general anesthetics, Abrams, S.B. and Yager, P., SPIE Proceedings, 1885, 62-71 (1993)

58. Effect of conjugation of phospholipid to poly(N-isopropylacrylamide) on its critical solution temperature, Wu, X.S., Hoffman, A.S., and Yager, P., Makromol. Chem. Rapid Commun., 14, 309-314 (1993)

59. Raman spectroscopic analysis of the secondary structure of spider silk fiber, Gillespie, D.B. , Viney, C., and Yager, P., in Silk Polymers: Materials Science and Biotechnology, D. Kaplan, et al., Editor. American Chemical Society: Washington, DC. pp. 155-167 (1994)

60. Fiber optic sensor for general anesthetics based on Raman spectroscopy, MacDonald, H.L, Liu, H., and Yager, P., SPIE Proceedings, 2131, 514-524 (1994)

61. Structural investigation of (Ad II)26 fiber, a novel bioengineered material based on a viral spike protein, Gillespie, D.B, Thiel, B.L., Trabbic, K.A, Viney, C, and Yager, P., Macromolecules, 27, 6177-6182 (1994)

62. Modeling success and failure of Langmuir-Blodgett transfer of phospholipid bilayers to silicon dioxide, Osborn, T.D. and Yager, P., Biophys. J., 68, 1364-1373 (1995)

63. Modeling of optical bending losses in multimode waveguides by ray tracing, Liu, H. and Yager, P. SPIE Proceedings, 2396, 120-129 (1995)

64. Application of multiplicative signal correction (MSC) to Raman spectra for use in an anesthetic sensor, Parnell, J.R. and Yager, P. SPIE Proceedings, 2388, 481-492 (1995)

65. Freely suspended solvent-free lipid bilayers by Langmuir-Blodgett transfer to micromachined apertures in silicon, Osborn, T.D. and Yager, P., Langmuir, 11, 8-12 (1995)

66. Silicon microchannel optical flow cytometry, Altendorf, E., Yager, P., Iverson, E., Yu, H., Osborn, T., Proceedings of the CHI Microfabrication Technology for Research and Diagnostics Conference, San Francisco, Sept. 28-29 (1995).

67. Liposome-based optical sensor for general anesthetics: Implementation of phase transition sensing, Yager, P., Abrams, S.B., and Merlo, S., in Biophysics of Organized Lipid Membranes for Applications in Chemical Analysis; Current Topics in Biophysics, Vol. 3 229-270, Krull, U.J., Ed., Iasi University Press, Iasi, Romania, (1995)

68. Sensors, Yager, P., in Biomaterials Science: An Introductory Text, Ratner, B.D. and Hoffman, A.S., Eds. Academic Press, Inc., Orlando, (1996)

69. Low Reynolds number micro-fluidic devices, Brody, J.P. and Yager, P., Proceedings Hilton Head MEMS conference, Solid-State Sensor and Actuator Workshop, 105-108, (1996).

70. A planar microfabricated fluid filter , Brody, J.P., Osborn, T.D., Forster, F.K. and Yager, P., (Proceedings of Transducers '95), Sensors and Actuators A (Physical), A54 (1-3), 704-708, (1996).

71. Optimal design of a microfabricated diffusion-based extraction device, Holl, M.R., Galambos, P., Forster, F.K., Brody, J.P., Afromowitz, M.A., and Yager, P., Proceedings of 1996 ASME Meeting ASME DSC59, 189-195 (1996)

72. Feasibility study for the measurement of oxyhemoglobin using whole blood without pretreatment, Wu, C., Kenny, M.A., Huang, M., Afromowitz, M.A., and Yager, P., Clinical Chemistry 42:S283, (1996).

73. Biotechnology at low Reynolds numbers, Brody, J.P., Yager-P., Goldstein, R.E., and Austin, R.H., Biophysical Journal. 71 (6), 3430-3441, (1996).

74. Optical flow cytometry utilizing microfabricated silicon flow channels, Altendorf, E., Iverson, E., Schutte, D., Weigl, B., Osborn, T.D., Sabeti, R., and Yager, P. SPIE Proceedings, Vol. 2678, 267 (1996).

75. Diffusion-based optical chemical detection in silicon flow structures, Weigl, D.H., Holl, M.R., Schutte, D., Brody, J., Yager, P., Analytical Methods & Instrumentation, Proceedings of µTAS '96, 174-184, (1996).

76. Rapid sequential chemical analysis using multiple fluorescent reporter beads, Weigl, B.H., Huang, M.C., van den Engh, G., Kaiser, R., Altendorf, E., Afromowitz, M., Yager, P., Analytical Methods & Instrumentation, Proceedings of µTAS '96, 255, (1996).

77. Fluorescent reporter beads for chemical analysis, Weigl, B.H., Huang, M.C., van den Engh, G., Kaiser, R., Altendorf, E., Afromowitz, M., Yager, P., Analytical Methods and Instrumentation, Proceedings of µTAS '96, pp. 174-184, International Journal of New Techniques and Applications, Basel, Switzerland (1996).

78. Particle discrimination capabilities of a flow cytometer utilizing microfabricated flow channels, Altendorf, E., Zebert, D., Yager, P., Journal of Microelectromechanical Systems, July 26 (1996).

79. Silicon-microfabricated diffusion-based optical chemical sensor, Weigl, B.H. and Yager, P., (Conference Proceedings Europtrode III, 1996) Sensors and Actuators B (Chemical), B39 (1-3), 452-457 (1997).

80. Patterned sol-gel structures by micro molding in capillaries, Lochhead, M.J., Yager, P., Materials Research Society Symposium Proceedings. Vol. 444. 105-110, (1997).

81. Oxyhemoglobin measurement of whole blood specimens in a silicon microfabricated cuvette, Wu, C., Holl, M., Kenny, M.A., Yager, P., SPIE Proceedings, Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications, 2978, 155-164 (1997).

82. Development of silicone waveguides for use in a Raman spectroscopy-based sensor for general anesthetics, Parnell, J.R., Schutte, D. and Yager, P., SPIE Proceedings, 2976, 20-29 (1997)

83. Prominent microscopic effects in microfabricated fluid analysis systems, Brody, J.P., Kamholz, A.E., Yager, P., SPIE Proceedings, Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications, 2978, 103-110, (1997).

84. Microfabricated interlock system for precision alignment, Sabeti, R., Holl, M.R., Altendorf, E.A., and Yager, P., SPIE Proceedings, Micro- and Nanofabricated Electro-Optical Mechanical Systems for Biomedical and Environmental Applications, 2978, 180-185, (1997).

85. Zero-order interfacial enzymatic degradation of phospholipid tubules, Carlson, P.A., Gelb, M.H., and Yager, P., Biophysical Journal, 73(1), 230-239 (1997).

86. Formation of high axial ratio microstructures from natural and synthetic sphingolipids, Goldstein, A.S., Lukyanov, A.N., Carlson, P., Yager, P., and Gelb, M.H., Chem. Phys. Lipids, 88, 21-36 (1997).

87. Diffusion-based extraction in a microfabricated device, Brody, J.P. and Yager, P., Sensors and Actuators A (Physical), A58(1), 13-18 (1997)

88. Multi-component micro-patterned sol-gel materials by capillary molding, Lochhead, M.J. and Yager, P., Sol-Gel Optics IV, SPIE Proc. Ser. 3136, 261-266 (1997)

89. Differential blood cell counts obtained using a microchannel based flow cytometer, Altendorf, E., Zebert, D., Holl, M., Yager, P., Proc. Transducers '97, 531-534, vol.1 (1997).

90. Comparative structural characterization of naturally and synthetically-spun fibers of Bombyx mori fibroin, Trabbic, K.A. and Yager, P., Macromolecules, 31(2), 462-471 (1998).

91. Formation of high axial ratio microstructures from peptides modified with glutamic acid dialkyl amides, Lee, K.J., Lukyanov, A.N., Gelb, M.H., and Yager, P., Biochim. Biophys. Acta, 1371, 168-184 (1998).

92. Integration of microelectrodes with etched microchannels for in-stream electrochemical analysis, Darling, R.B., Kriebel, J., Mayes, K.J., Weigl, B.H., and Yager, P., in Micro Total Analysis Systems '98, D. J. Harrison and A. van den Berg, eds. Kluwer Academic Publishers, Dordrecht, 105-108 (1998)

93. Applying microfluidic chemical analytical systems to imperfect samples, Yager, P., Bell, D., Brody, J.P., Qin, D., Cabrera, C., Kamholz, A., and Weigl, B.H., in Micro Total Analysis Systems '98, D. J. Harrison and A. van den Berg, eds., Kluwer Academic Publishers, Dordrecht, 207-212 (1998)

94. Simultaneous self-referencing analyte determination in complex sample solutions using microfabricated flow structures (T-Sensors), Weigl, B.H., Kriebel, J., Mayes, K.J., Yager, P. Wu, C.-C., Holl, M., Kenny, M. and Zebert, D., in Micro Total Analysis Systems '98, D. J. Harrison and A. van den Berg, eds., Kluwer Academic Publishers, Dordrecht, 81-84 (1998)

95. Design of microfluidic sample preconditioning systems for detection of biological agents in environmental samples, Yager, P., Afromowitz, M.A., Bell, D., Forster, F.K., Brody, J.P., Qin, D., Cabrera, C., Holl, M., Kamholz, A., and Weigl, B.H., SPIE Proceedings, 3515, 252-259 (1998)

96. Feasibility study of the spectroscopic measurement of oxyhemoglobin using whole blood without pre-treatment, Wu, C., Kenny, M.A., Huang, M.C., Afromowitz, M.A., and Yager, P., Analyst, 123(3), 477-481 (1998)

97. Microfluidic diffusion-based separation and detection, Weigl, B.H. and Yager, P., Science, 283(5400), 346-347 (1999)

98. Quantitative analysis of molecular interaction in a microfluidic channel: the T-sensor, Kamholz, A.E., Weigl, B.H., Finlayson, B.A. and Yager, P., Analytical Chemistry, 71(23), 5340-5347 (1999)

99. Microfabricated silicon flow-cell for optical monitoring of biological fluids, Chau, L.-K., Osborn, T., Wu, C.-C., and Yager, P., Analytical Sciences, 15, 721-724 (1999)

100. Protection of lipopeptide from proteolytic cleavage by self-assembly into lipid tubules. Model sustained release drug delivery system, Lee, K.C., Yager, P., and Gelb, M.H., Langmuir, 15 (17), 5500-5508 (1999).

101. Whole blood diagnostics in standard gravity and microgravity by use of microfluidic structures (T-sensors), Weigl, B.H., Kriebel, J., Mayes, K.J., Bui, T. and Yager, P., Mikrochimica Acta, 131, 75-83 (1999)

102. A microfluidic sedimentation particulate capture device with internal degassing membranes, Holl, M.M., Macounova, K., and Yager, P., in Micro Total Analysis Systems 2000, van den Berg, Olthuis and Bergveld, eds., Kluwer Academic Publishers, Dordrecht, 15-18 (2000).

103. Analytical devices based on transverse transport in microchannels, Yager, P., Cabrera, C., Hatch, A., Hawkins, K., Holl, M., Kamholz, A., Macounova, K., and Weigl, B.H., in Micro Total Analysis Systems 2000, van den Berg, Olthuis and Bergveld, eds., Kluwer Academic Publishers, Dordrecht, 319-322 (2000)

104. Generation of natural pH gradients in microfluidic channels for use in isoelectric focusing, Macounová, K., Cabrera, C.R., Holl, M.R. and Yager, P., Analytical Chemistry, 72(16), 3745-3751 (2000).

105. Use of isoelectric focusing for sample preconditioning in a microfluidic electrochemical flow cell, Cabrera, C.R., Macounová, K., Holl, M.R., and Yager, P., Proceedings of the IEEE 1st Annual Conference on Microtechnology in Medicine and Biology, Lyon France, October, 2000, D. Beebe, Ed.,IEEE Press (2000)

106. Theoretical analysis of molecular diffusion in pressure-driven laminar flow in microfluidic channels, Kamholz, A.E. and Yager, P., Biophysical Journal, 80, 155-160 (2001)

107. Formation of natural pH gradients in a microfluidic device under flow conditions: Model and experimental validation, Cabrera, C.R., Finlayson, B.A., and Yager, P., Analytical Chemistry, 73(3), 658-666 (2001)

108. Continuous concentration of bacteria in a microfluidic flow cell using electrokinetic techniques, Cabrera, C.R. and Yager, P., Electrophoresis, 22(2), 355-362 (2001)

109. A rapid diffusion immunoassay in a T-Sensor, Hatch, A., Kamholz, A.E., Hawkins, K.R., Munson, M.S., Schilling, E.A., Weigl, B.H. and Yager P., Nature Biotechnology, 19(5), 461- 465 (2001)

110. The relationship between the structure of the headgroup of sphingolipids and their ability to form complex high axial ratio microstructures, Goldstein, A.S., Gelb, M.G. and Yager, P., Chem. Phys. Lipids., 109(1), 1-14 (2001)

111. Continuous and highly variable rate controlled release of model drugs from sphingolipid-based complex high axial ratio microstructures, Goldstein, A.S., Yager, P. and Gelb, M.H., J. Controlled Release, 70(1-2), 125-138 (2001)

112. Optical measurement of transverse molecular diffusion in a microchannel, Kamholz, A.E., Schilling, E.A. and Yager, P., Biophysical Journal, 80(4), 1967-1972 (2001)

113. Concentration and separation of proteins in microfluidic channels on the basis of transverse IEF, Macounová, K., Cabrera, C.R., and Yager, P., Analytical Chemistry, 73(7), 1627-1633 (2001)

114. A ferrofluidic magnetic micropump, Hatch, A., Kamholz, A.E., Holman, G., Yager, P., and Böhringer, K.F., Journal of MEMS, 10(2), 1-7 (2001)

115. Mapping of pH gradients in microfluidic electrokinetic devices, Cabrera, C.R., and Yager, P., in Micro Total Analysis Systems 2001, Ramsay, J.M. & van den Berg, A., eds., Kluwer Academic Publishers, Dordrecht, 105-106 (2001)

116. Cell lysis and protein extraction in a microfluidic device with detection by a fluorogenic enzyme assay, Schilling, E.A., Kamholz, E.A., and Yager P., in Micro Total Analysis Systems 2001, Ramsay, J.M. & van den Berg, A., eds., Kluwer Academic Publishers, Dordrecht, 265-267 (2001)

117. Diffusion immunoassay in polyacrylamide hydrogels, Hatch, A. and Yager, P., in Micro Total Analysis Systems 2001, Ramsay, J.M. & van den Berg, A., eds., Kluwer Academic Publishers, Dordrecht, 571-572 (2001)

118. Testosterone delivery using glutamide based complex high axial ratio microstructures, Goldstein, A.S., Amory, J.K., Martin, S.M., Vernon, C., Matsumoto, A.M., and Yager, P., Bioorganic and Medicinal Chemistry, 9(11), 2819-2825 (2001).

119. Molecular diffusive scaling laws in pressure-driven microfluidic channels: deviation from one-dimensional Einstein approximations, Kamholz, A.E. and Yager, P. Sensors and Actuators B, 82(1), 117-121 (2002).

120. Cell lysis and protein extraction in a microfluidic device with detection by a fluorogenic enzyme assay, Schilling, E.A., Kamholz, A.E., and Yager, P., Analytical Chemistry, 74(8), 1798-1804 (2002)

121. Diffusion immunoassay for protein analytes, Hawkins, K.R., Hatch, A., Chang, H., and Yager, P. in Proceedings of Microtechnologies in Medicine and Biology, Madison, WI, IEEE Press, 535-540, (2002)

122. Passive electrophoresis in microchannels using liquid junction potentials. Munson, M.S., Cabrera, C.R, and Yager, P. Electrophoresis, 23, 2642-2652 (2002).

123. Wavelength-tunable surface plasmon resonance microscope, Fu, E., Foley, J., and Yager, P., Review of Scientific Instruments, 74(6), 3182-3184 (2003)

124. A smart microfluidic affinity chromatography matrix composed of poly(N-isopropylacrylamide)-coated beads, Malmstedt, N., Yager, P., and Stayton, P., Analytical Chemistry, 75(13), 2943-2949 (2003)

125. Nonlinear decay of background fluorescence in polymer thin-films - a survey of materials and how they can complicate fluorescence detection in µTAS, Hawkins, K.R. and Yager, P., Lab on a Chip, 3(4), 255-259 (2003)

126. Transverse diffusion in microfluidic systems, Yager, P., in Lab-on-a-chip: Chemistry in Miniaturized Synthesis and Analysis Systems, R.E. Oosterbroek, R.E., and van den Berg, A., Eds., (2003)

127. Analysis of molecular binding to human serum albumin using a T-sensor, A. Hatch, E. Garcia, and P. Yager, in Micro Total Analysis Systems 2003, Northrup, M.A., Jensen, K.F., and Harrison, D.J, eds., Mesa Monographs, 1215-1218 (2003)

128. T-sensor generated refractive index gradients: calibration of an SPR microscope, J. Foley, E. Fu, and P. Yager, in Micro Total Analysis Systems 2003, Northrup, M.A., Jensen, K.F., and Harrison, D.J, eds., Mesa Monographs, 967-970 (2003)

129. Capture-and-release concentration of bacteria using free-flow zone electrophoresis, K.J Halle, J.J. Li, M.S. Munson, J. Monteith, E. Guzman, S. Feather, J. Verba, Q. Porter, V. Kenning, A.E. Kamholz, B.H. Weigl, P. Saltsman, R. Bardell, and P. Yager, in Micro Total Analysis Systems 2003, Northrup, M.A., Jensen, K.F., and Harrison, D.J, eds., Mesa Monographs, 559-562 (2003)

130. Modeling controlled release from cavities in microchannels, E. Garcia, F. Kusmanto, B. Finlayson, and P. Yager, in Micro Total Analysis Systems 2003, Northrup, M.A., Jensen, K.F., and Harrison, D.J, eds., Mesa Monographs, 551-554 (2003)

131. A novel microfluidic mixer based on successive lamination, M.S. Munson and P. Yager, in Micro Total Analysis Systems 2003, Northrup, M.A., Jensen, K.F., and Harrison, D.J, eds., Mesa Monographs, 495-498 (2003)

132. On the importance of quality control in microfluidic device manufacturing, M.R. Steedman, K.M. Lloyd, M.S. Munson, and P. Yager, in Micro Total Analysis Systems 2003, Northrup, M.A., Jensen, K.F., and Harrison, D.J, eds., Mesa Monographs, 1069-1072 (2003)

133. Simple quantitative optical method for monitoring the extent of mixing applied to a novel microfluidic mixer, Munson, M.S. and Yager, P., Analytica Chimica Acta, 501(1), 63-71 (2004)

134. Controlled microfluidic reconstitution of functional protein from an anhydrous storage depot, Garcia, E., Kirkham, J. R., Hatch, A.V, Hawkins, K.R. and Yager, P., Lab on a Chip, 4, 78-82 (2004)

135. Characterization of a wavelength-tunable surface plasmon resonance microscope, Fu, E., Chinowsky T., Foley, J., Weinstein J., and Yager, P., Review of Scientific Instruments, 75(7), 2300-2304 (2004).

136. Diffusion-based analysis of molecular interactions in microfluidic devices, Hatch, A., Garcia, E. and Yager, P., IEEE Proceedings, 92(1), 126-139 (2004)

137. Suppression of non-specific adsorption using sheath flow, Munson, M. S., Hasenbank, M. S., Fu, E. and Yager, P., Lab on a Chip, 4, 438-445 (2004)

138. Parallel microfluidic processing of protein assembly quantified using SPR microscopy, Blaylock, M., Fu, E. and Yager, P., Micro Total Analysis Systems 2004, Vol. 1., Laurell, Nilson, Jensen, Harrison and Kutter, Eds., RSC Press, 354-356 (2004)

139. The aggregation of multivalent immune complexes expands the useful analyte size range of the diffusion immunoassay, Hawkins, K.R. and Yager, P., Micro Total Analysis Systems 2004, Vol. 1., Laurell, Nilson, Jensen, Harrison and Kutter, Eds., RSC Press, 129-131 (2004)

140. Diffusion based analysis in a sheath flow microchannel: the sheath flow T-sensor, Munson, M. S., Hawkins, K. R., Hasenbank, M. S., and Yager, P., Lab on a Chip, 5, 856-862 (2005)

141. Lab-on-a-chip and fluorescence sensing on the microscale, Chang, H. N., Hatch, A. V., Hawkins, K. R. and Yager, P., in Fluorescence Sensors and Biosensors, R. B. Thompson, ed., ISBN 0-8247-2737-1, CRC Press, Boca Raton, FL, c.400 pp (2005)

142. Transverse transport in microsystems: theory and applications, Yager, P., Cabrera, C. and Kamholz, A.E., in Separation Methods in Microanalytical Systems, Jörg P. Kutter and Yolanda Fintschenko, Eds., CRC Press, Boca Raton, FL (2005)

143. Investigation of a rapid microfluidic surface plasmon resonance imaging (SPRI) signal amplification scheme based on the rate of formation of an enzyme-catalyzed precipitate, Hasenbank, M., Fu, E. and Yager, P., Micro Total Analysis Systems 2005, Vol. 1, Jensen, K.F., Han, J., Harrison, D.J. and Voldman, J., Eds., Transducer Research Foundation, Pubs., 485-487 (2005)

144. Rapid, parallel-throughput, multiple analyte immunoassays with on-board controls on an inexpensive, disposable microfluidic device, Nelson, K.E., Foley, J.O., Mashadi-Hossein, A., and Yager, P., Micro Total Analysis Systems 2005, Vol. 2, Jensen, K.F., Han, J., Harrison, D.J. and Voldman, J., Eds., Transducer Research Foundation, Pubs., 1000-1002 (2005)

145. Microfluidic high throughout screening of enzyme inhibition in a T-sensor, Garcia, E. and Yager, P. Micro Total Analysis Systems 2005, Vol. 2, Jensen, K.F., Han, J., Harrison, D.J. and Voldman, J., Eds., Transducer Research Foundation, Pubs., 1443-1445 (2005)

146. A novel method of fluorescence detection and spectroscopy, Thariani, R. and Yager, P., Micro Total Analysis Systems 2005, Vol. 2, Jensen, K.F., Han, J., Harrison, D.J. and Voldman, J., Eds., Transducer Research Foundation, Pubs., 1470-1472 (2005).

147. Wavelength-dependent signal amplification potential of gold nanocage tags for surface plasmon resonance (SPR) imaging, Fu, E., Foley, J. O., Chen, J., Wiley, B., Xia, Y. and Yager, P. Micro Total Analysis Systems 2005, Vol. 2, Jensen, K.F., Han, J., Harrison, D.J. and Voldman, J., Eds., Transducer Research Foundation, Pubs., 1510-1512 (2005).

148. Cross-talk problem on a fluorescence multi-channel microfluidic chip system, Irawan, R., Tjin, S., Yager, P., and Zhang, D. Biomedical Microdevices, 7 (3), 205-211 (2005)

149. Fully integrated multiplexed lab-on-a-card assay for enteric pathogens, Weigl, B. H., Gerdes, J., Tarr, P., Yager, P., Dillman, L., Peck, R., Ramachandran, S., Lemba, M., Kokoris, M., Nabavi, M., Battrell, F., Hoekstra, D., Klein, E. J. and Denno, D. M., Proc. SPIE, 6112, 11 pp. (2006)

150. Microfluidic diagnostic technologies for global public health, Yager, P., Edwards, T., Fu, E., Helton, K., Nelson, K., Tam, M. and Weigl, B., Nature, 442(7101). 412-418 (2006)

151. One-dimensional surface plasmon resonance imaging system using wavelength interrogation, Fu, E., Ramsey, S., Thariani, R., and Yager, P., Review of Scientific Instruments, 77 (7): Art. No. 076106 (2006)

152. Recirculating flow accelerates DNA microarray hybridization in a microfluidic device, Lee, H.H., Smoot, J., McMurray, Z., Stahl, D. A., and Yager, P., Lab on a Chip, 6 (9): 1163-1170 (2006)

153. Lateral spread of an amplification signal using an enzymatic system on a conductive surface, Hasenbank, M. S., Fu, E., and Yager, P., Langmuir, 22 (18): 7451-7453 (2006)

154. Rapid, multiplexed competitive immunoassays using disposable microfluidic devices and SPR imaging, Nelson, K, Geisler, N., Tandon, K., and Yager, P. Micro Total Analysis Systems 2006, Vol. 1, Kitamori, T., Fujita, H., and Hasebe, S., Eds., Society for Chemistry and Micro-Nano Systems, Pubs., 825-827 (2006).

155. A novel, low-cost, compact, laser pointer driven surface plasmon resonance system, Thariani, R., and Yager, P. Micro Total Analysis Systems 2006, Vol. 1, Kitamori, T., Fujita, H., and Hasebe, S., Eds., Society for Chemistry and Micro-Nano Systems, Pubs., 1256-1258 (2006).

156. Spreading small signals over large areas: electrochemical amplification in an SPR imaging sensor array, Hasenbank, M. S., Fu, E., and Yager, P. in Micro Total Analysis Systems 2006, Vol. 1, Kitamori, T., Fujita, H., and Hasebe, S., Eds., Society for Chemistry and Micro-Nano Systems, Pubs., 1286-1288 (2006).

157. Resonance wavelength-dependent signal of absorptive particles in surface plasmon resonance-based detection, Fu, E., Ramsey, S., Chen, J., Chinowsky, T. M., Wiley, B., Xia, Y., and Yager, P., Sensors and Actuators B: Chemical, 123 (1): 606-613 (2007)

158. High-throughput screening of enzyme inhibition using an inhibitor gradient generated in a microchannel, Garcia, E. L., Hasenbank, M., Finlayson, B., and Yager, P., Lab on a Chip, 7, 249-255 (2007)

159. Compact, high performance surface plasmon resonance imaging system, Chinowsky, T. M., Grow, M. S., Johnston, K. S., Nelson, K., Edwards, T., Fu, E., and Yager, P, Biosensors and Bioelectronics, 22(9-10): 2208-2215 (2007)

160. A method for characterizing adsorption of flowing solutes to microfluidic device surfaces, Hawkins, K. R., Steedman, M. R., Baldwin, R. R., Fu, E., Ghosal, S., and Yager, P., Lab on a Chip, 7(2), 281-285 (2007)

161. SPR imaging-based salivary diagnostics system for the detection of small molecule analytes, Fu, Elain, Chinowsky, T., Nelson, K., Johnston, K., Edwards, T., Helton, K., Grow, J., Miller, J. W., and Yager, P., Ann. N.Y. Acad. Sci. 1098: 335–344 (2007)

162. Concentration gradient immunoassay I. a rapid immunoassay based on interdiffusion and surface binding in a microchannel, Nelson, K. E., Foley, J. O., and Yager, P., Analytical Chemistry, 79(10): 3542-3548 (2007)

163. Concentration gradient immunoassay II. computational modeling for analysis and optimization, Foley, J. O., Nelson, K. E., Mashadi-Hossein, A., Finlayson, B.A., and Yager, P. Analytical Chemistry, 79(10): 3549-3553 (2007)

164. Investigation of heterogeneous electrochemical processes using multi-stream laminar flow in a microchannel, Hasenbank, M. S., Fu, E., Nelson, J. B., Schwartz, D. T., and Yager, P., Lab on a Chip, 7(4): 441-447 (2007)

165. Dependence of the signal amplification potential of colloidal gold nanoparticles on resonance wavelength in surface plasmon resonance-based detection, Fu, E., Ramsey, S.A., and Yager, P., Analytica Chimica Acta, 599(1): 118-123 (2007)

166. Interfacial instabilities affect microfluidic extraction of small molecules from non-Newtonian fluids, Helton, K.L. and Yager, P., Lab on a Chip, 7(11):1581-1588 (2007)

167. Microfluidic lab-on-a-chip for microbial identification on a DNA microarray, Lee, H.H. and Yager, P., Biotechnology and Bioprocess Engineering, 12:634-639 (2007)

168. Microcontact printed antibodies on gold surfaces: function, uniformity, and silicone contamination, Foley, J., Fu, E., Gamble, L. and Yager, P., Langmuir, 24(7):3628-3635 (2008)

169. Experimental and model investigation of the time-dependent 2-dimensional distribution of binding in a herringbone microchannel, Foley, J.O., Mashadi-Hossein, A., Fu, E., Finlayson, B.A., and Yager, P., Lab on a Chip, 8(4): 557-564 (2008)

170. Demonstration of multi-analyte patterning using piezoelectric inkjet printing of multiple layers, Hasenbank, M.S., Edwards, T., Fu, E., Garzon, R., Kosar, T.F., Look, M., Mashadi-Hossein, A., and Yager, P., Analytica Chimica Acta, 611(1),: 80-88 (2008)

171. SPR imaging for clinical diagnostics, Fu, E., Chinowsky, T., Nelson, K. and Yager, P., in Handbook of Surface Plasmon Resonance, Schasfoort, R.B.M. and Tudos, A.J., eds., RSC Publishing, Enschede, (2008)

172. Point-of-care diagnostics for global health. Yager, P., Domingo, G.J., and Gerdes, J., Annual Review of Biomedical Engineering, 10: 107-144 (2008)


173. Molecular (PCR based) diagnostics for low-resource or point-of-care settings, Dr J. C. Gerdes, J.C., Weigl, B., Yager, P. and Tarr, P.I., CLi, 5: 22-25 (2008)

174. Conditioning saliva for use in a microfluidic biosensor, Helton, K.L, Nelson, K.E., Fu, E. and Yager, P., Lab on a Chip, 8: 1847 – 1851 (2008)

175. Enabling a microfluidic immunoassay for the developing world by integration of on-card dry reagent storage, Stevens, D.Y., Petri, C.R., Osborn, J.L., Spicar-Mihalic, P., McKenzie, K.G., and Yager, P., Lab on a Chip, 8: 2038-2045 (2008)

176. Novel, high-quality surface plasmon resonance microscopy, Thariani, R., and Yager, P., Sensors & Actuators: B. Chemical, 130: 765-770 (2008)

177. A practical guide to the staggered herringbone mixer. Williams, M.S., Longmuir, K.J., and Yager, P., Lab on a Chip, 8(7): 1121-1129 (2008).

178. On-chip detection of myoglobin based on fluorescence, Darain, F., Yager, P, Gan, K.L., and Tjin, S.C., Biosensors and Bioelectronics, 24: 1744-1750 (2009).

179. Dynamic bioprocessing and microfluidic transport control with smart magnetic nanoparticles in laminar-flow devices, Lai, J.J., Nelson, K., Nash, M.A, Hoffman, A.S., Yager, P. and Stayton, P.S., Lab on a Chip, 9: 1997-2002 (2009)

180. Modeling of a competitive microfluidic heterogeneous immunoassay: sensitivity of the assay response to varying system parameters, Fu, E., Nelson, K., Ramsey, S. Foley, J.O., Helton, K. and Yager, P., Analytical Chemistry, 81(9): 3407-3413 (2009)

181. Rapid protein depletion from complex samples using a bead-based microfluidic device for the point of care, McKenzie, K.G., Lafleur, L.K., Lutz, B.R. and Yager, P., Lab on a Chip, 9: 3543-3548 (2009)

182. “Smart” diblock copolymers as templates for magnetic-core gold-shell nanoparticle synthesis, Nash, M.N., Lai, J.J., Hoffman, A.S., Yager, P., and Stayton, P.S., Nano Letters, 10(1): 85-91 (2010)

183. Controlled reagent transport in disposable 2D paper networks, Fu, E., Lutz, B., Kauffman, P. and Yager, P., Lab on a Chip, 10(7): 918-920 (2010)

184. Imaging of surfaces by concurrent surface plasmon resonance and surface plasmon resonance-enhanced fluorescence, Thariani, R. and Yager, P., PLoS ONE 5(3): e9833. doi:10.1371/journal.pone.0009833 (2010)

185. Visualization and measurement of flow in two-dimensional paper networks, Kauffman, P., Fu, E., Lutz, B. and Yager, P., Lab on a Chip, 10: 2614-2617 (2010)

186. Laboratory-scale protein striping system for patterning biomolecules onto paper-based immunochromatographic test strips, Nash, M.A., Hoffman, J.M., Stevens, D.Y., Hoffman, A.S., Stayton, P.S., and Yager, P., Lab on a Chip, 10(17): 2279-2282 (2010)

187. Chemical signal amplification in two-dimensional paper networks, Fu, E., Lutz, B., Kauffman, P. and Yager, P., Sensors & Actuators: B. Chemical, 149(1): 325-328 (2010)

188. Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks, Osborn, J.L., Lutz, B., Fu, E., Kauffman, P., Stevens, D. and Yager, P., Lab on a Chip, 10, 2659 – 2665 (2010)

189. Mixed stimuli-responsive magnetic and gold nanoparticle system for rapid purification, enrichment, and detection of biomarkers, Nash, M.A., Yager, P., Hoffman, A. S.), Stayton, P. S., Bioconjugate Chemistry, 23(12), 2197-2204 (2010)

190. Transport in two-dimensional paper networks, Fu, E., Ramsey S.A., Kauffman, P., Lutz, B., and Yager, P., Microfluidics and Nanofluidics, 10(1): 29-35 (2011)

191. Enhanced sensitivity of lateral flow tests using a two-dimensional paper network format, Fu, E., Liang, T., Houghtaling, J., Ramachandran, S., Ramsey, S.A., Lutz, B. and Yager, P. Anal. Chem., 83(20): 7941-7946 (2011)

192. Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper, Lutz, B. R., Trinh, P., Ball, C., Fu, E., Yager, P., Lab on a Chip, 11(24): 4272-4278 (2011)

193. A low cost point-of-care viscous sample preparation device for molecular diagnosis in the developing world; an example of microfluidic origami, Govindarajan, A.V., Ramachandran, S., Vigil, G.D., Yager, P. and Böhringer, K.F., Lab on a Chip, 12(1): 174-181 (2012)

194.  Progress toward multiplexed sample-to-result detection in low resource settings using microfluidic immunoassay cards, Lafleur, L., Stevens, D., McKenzie, K., Ramachandran, S., Spicar-Mihalic, P., Singhal, M., Arjyal, A., Osborn, J., Kauffman, P., Yager, P. and Lutz, B., Lab on a Chip, 12(6): 1119-1127 (2012) DOI: 10.1039/C2LC20751F

195.  A two-dimensional paper network format that enables simple multi-step assays for use in low-resource settings, Fu, E., Liang, T., Spicar-Mihalic, P., Houghtaling, J., Ramachandran, S. and Yager, P., Analytical Chemistry, 84(10): 4574-4579 (2012) DOI: 10.1021/ac300689s   Published: May 15 2012

196.  Multiplexed enrichment and detection of malarial biomarkers using a stimuli-responsive iron oxide and Gold Nanoparticle Reagent System, Nash, M.A., Waitumbi, J.N., Hoffman, A.S., Yager, P.,  and Stayton, P.SACS Nano,  6(8): 6776-6785 (2012)

197.  Controlled release of dry reagents in porous media for tunable temporal and spatial distribution upon rehydration, Fridley, G.E., Le. H.Q., Fu, E., and Yager, P., Lab on a Chip, 12(21): 4321-4327 (2012)

198.  A rapid, multiplexed, high-throughput flow-through membrane immunoassay: a convenient alternative to ELISA, Ramachandran, S., Singhal, M., Mckenzie, K., Osborn, J., Arjyal, A., Dongol, S., Baker, S., Basnyat, B., Farrar, J., Dolecek, C., Domingo, G., Yager, P., and Lutz, B., Diagnostics, 3: 244-260 (2013)

199.  The evolution of nitrocellulose as a material for bioassays, Fridley, G.E., Holstein, C.A., Oza. S.B., and Yager, P., MRS Bulletin, 38(04): 326-330 (2013)

200.  CO2 laser cutting and ablative etching for the fabrication of paper-based devices, Spicar-Mihalic, P., Liang, T., Yager, P. and Fu, E., Journal of Micromechanics and Microengineering, 23: 067003 (2013)

201. Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics, Lutz, B., Liang, T., Fu, E., Ramachandran, S., Kauffman, P. and Yager, P., Lab on a Chip, DOI: 10.1039/ c3lc50178g, in press

 


PRESENTATIONS:

1. Raman spectroscopic monitoring of the kinetics of pressure-jump induced phase transitions in phospholipid dispersions, Yager, P. and Peticolas, W.L., presented at VII International Biophysics Congress, Mexico City, August, 1981

2. Encapsulation of hemoglobin in phospholipid vesicles, Gaber, B.P., Yager, P., Sheridan, J.P. and Chang, E.L., Biophysical Journal, 37, 145a (1982), presented at Biophysical Society Meeting, Boston, February, 1982

3. Optical microscopy of multilamellar phospholipid dispersions undergoing phase transitions, Yager, P., Biophysical Journal, 37, 198a (1982), presented at Biophysical Society Meeting, Boston, February, 1982

4. The secondary structure of the reconstituted acetylcholine receptor as determined by Raman spectroscopy, Chang, E.L., Yager, P., Williams, R.W. and Dalziel, A.W., Biophysical Journal, 41, 65a (1983), presented at Biophysical Society Meeting, San Diego, February, 1983

5. The inverted hexagonal phase of phosphatidylethanolamine is antagonized by high pressure, Yager, P. and Chang, E.L., Biophysical Journal, 41, 347a (1983), presented at Biophysical Society Meeting, San Diego, February, 1983

6. Spectroscopic studies of polymerizable surfactants, Yager, P., Priest, R.G., and Schoen, P.E., presented at GTE Symposium on Order in Polymeric Materials, Waltham, Mass., August, 1983

7. Spectroscopic studies of polymerized surfactants, Schoen, P.E., Yager, P. and Priest, R.G., presented at NATO Advanced Science Institute on Polydiacetylenes, Stratford on Avon, U.K., August, 1984

8. Patch clamping of bacteriorhodopsin and its reconstitution in a polymerizable lecithin, Yager, P., Biophysical Journal, 47, no. 2, 93a (1985), presented at Biophysical Society Meeting, Baltimore, February, 1985

9. The effects of pressure on the fusion of lipid vesicles, Chang, E.L., and Yager, P., Biophysical Journal, 47, no. 2, 108a (1985), presented at Biophysical Society Meeting, Baltimore, February, 1985

10. The structure of polymerized lipid tubules, Schoen, P.E., Yager, P., Singh, A., Davies, C., Price, R., and Schnur, J.M., presented at CRDC Conference on Obscuration and Aerosol Research, Aberdeen, June, 1985

11. The structure of tubules formed from a polymerizable lipid, Yager, P., and Schoen, P.E., invited talk at Gordon Conference on Macromolecular and Micellar Catalysis, Brewster Academy, July, 1985

12. The structure of tubules formed from a polymerizable lipid, Yager, P., and Schoen, P.E., invited talk at National Bureau of Standards, Gaithersburg, November, 1985

13. Protein reconstitution in polymerized substrates, Yager, P., invited talk at conference entitled "New Applications of Phospholipid Bilayers, Thin Films and Vesicles", Tenerife, Spain, January, 1986

14. Two mechanisms for forming novel tubular microstructures from polymerizable lipids, Yager, P., Schoen, P.E., Georger, J., Price, R., and Singh, A., Biophysical Journal, 49, no. 2, 320a (1986), presented at Biophysical Society Meeting, San Francisco, February, 1986

15. Reconstitution of acetylcholine receptor from Torpedo californica in polymerizable lipids, Dalziel, A.W., Price, R., Singh, A., and Yager, P., Biophysical Journal, 49, no. 2, 362a (1986), presented at Biophysical Society Meeting, San Francisco, February, 1986

16. Structure determination for drugs and drug/lipid complexes, Rhodes, D.G., Yager, P., Schoen, P.E., and Herbette, L.G., presented at American Crystallographic Association Meeting, June 1986

17. Reconstitution of acetylcholine receptor from Torpedo californica in polymerizable lipids, Dalziel, A.W., Georger, J., Price, R., Singh, A., and Yager, P., presented at Membrane Protein Symposium, San Diego, 1986

18. Orientation of lipid tubules by a magnetic field, Rosenblatt, C., Yager, P., and Schoen, P.E., Biophys. J., 51:185a (1987) presented at Biophysical Society Meeting, New Orleans, February, 1987

19. Phase behavior of a homologous series of polymerizable phospholipids: effect of diacetylene group position on tubule formation, Burke, T.G., Rudolph, A.S., Singh, B.P., Sheridan, J.P., Singh, A., Yager, P., and Schoen, P.E., Biophys. J., 51:185a (1987) presented at Biophysical Society Meeting, New Orleans, February, 1987

20. Structure of polymerized diacetylenic lipid bilayers, Rhodes, D.G., Blechner, S., Schoen, P.E., and Yager, P., Biophys. J., 51:527a (1987) presented at Biophysical Society Meeting, New Orleans, February, 1987

21. Acetylcholine receptor in planar polymerized bilayers--toward a receptor-based biosensor, Yager, P., Dalziel, A.W., Georger, J., Price, R.R., and Singh, A., Biophys. J., 51:143a (1987) presented at Biophysical Society Meeting, New Orleans, February, 1987

22. Measurement of alamethicin-mediated ion translocation through asymmetric polymerized lipid bilayers, Yager, P. and Seib, K., Biophys. J., 53:9a (1988) presented at Biophysical Society Meeting, Phoenix, February 1988

23. Application of patch clamp techniques for the development of membrane-based biosensors, Person, J.J. and Yager, P., 63rd Colloid and Surface Science Symposium, Seattle, June 1989

24. An optical method for detecting the depth of Anesthesia, Merlo, S., Burgess, L.W. and Yager, P., 63rd Colloid and Surface Science Symposium, Seattle, June 1989

25. Spectroscopic analysis and microscopic examination of tubule-forming lipid membranes, Archibald, D.D. and Yager, P., 63rd Colloid and Surface Science Symposium, Seattle, June 1989

26. An optical method for detecting the depth of anesthesia, Merlo, S., Burgess, L.W., and Yager, P., presented at Transducers '89 (5th International Conference of Solid-State Sensors and Actuators & Eurosensors III), Montreux, Switzerland, June 1989

27. Development of a fiber optic sensor for general anesthetics and other small organic molecules, Yager, P., et al., invited talk at Gordon Research Conference on Bioanalytical Sensors, Ventura, CA, March 1990

28. Development of a fiber optic biosensor for measurement of general anesthetics, Yager, P., et al., invited talk at Workshop on Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, Marina del Rey, CA, May 1990

29. The use of polymeric lipids in receptor-based biosensors, Yager, P. et al., invited talk (and session co-chair) at 33rd IUPAC Symposium on Macromolecules, Montreal, July 1990

30. Formation of tubular, helical, and cochleate structures from bilayer-forming lipids, Yager P., et al., invited talk at Membrane Structure and Function: The State of the Art--Proceedings of the Indo-U.S. Workshop, Bangalore and Hyderabad, India, January, 1991

31. Development of biosensors based on biomembranes, Yager P., et al., invited talk at Membrane Structure and Function: The State of the Art--Proceedings of the Indo-U.S. Workshop, Bangalore and Hyderabad, India, January, 1991

32. Phase transition sensing for general anesthetics and other small organic molecules, Yager P., et al., invited talk at Washington Exhibition of Science and Technology 1991, Seattle, WA, April 1991

33. Detection of volatile and soluble general anesthetics using a fluorescence-based fiber optic sensor: Recent progress in chemical sensitivity and noise, invited talk at SPIE Biomedical Optics '92, Los Angeles, January 1992

34. Quantitative formation of helical and rodlike microstructures from biological lipids: brain galactocerebroside (Gal-Cer) and its two major subfractions, Yager, P and Archibald, D.D., presented at Biophysical Society meeting, Houston, February, 1992

35. Use of a visible fluorescence dye in a fiberoptic sensor to detect general anesthetics, Susan B. Abrams and Paul Yager, invited talk at SPIE Biomedical Optics '92, Los Angeles, January 1993

36. Raman spectroscopic analysis of the secondary structure of spider silk fiber, invited talk at Army/Air Force Silk Symposium, Charlottesville, VA, January 1993

37. Raman spectroscopy of spider silk: A structural biomaterial? invited talk for Chevron Lecture Series, Department of Chemical Engineering, University of Washington, May 1993

38. Fiber optic sensor for general anesthetics based on Raman spectroscopy, Hillary L. MacDonald and Paul Yager, invited talk at SPIE Biomedical Optics '94, Los Angeles, January 1994

39. Freely suspended solvent-free phospholipid bilayers formed by Langmuir-Blodgett transfer to micromachined apertures in silicon. Osborn, T.D. and Yager, P., presented at Biophysical Society meeting, New Orleans, March, 1994

40. Self-organization of fibroin in silk fibers, Trabbic, K.A., Thiel, B.L., Gillespie, D.B., Viney, C and Yager, P., presented at Biophysical Society meeting, New Orleans, March, 1994

41. A novel drug delivery system based on degradation of tubule lipid microstructures, Carlson, P.A., and Gelb, M.H., and Yager, P., oral presentation at Materials Research Society meeting, Boston, December, 1995

42. Zero-order kinetics of hydrolysis of diacetylenic lipid tubules by phospholipase A2; the influence of microstructure on an interfacial enzyme, Yager, P, Carlson, P.A., and Gelb, M.H., Biophys. J., 70:249A (1996), oral presentation at Biophysical Society meeting, Baltimore, February, 1996

43. Silicon-microfabricated diffusion-based optical chemical sensor, Sensors & Actuators B - Chemical (Conference Proceedings Europtrode III) (1996), Weigl, B.H. and Yager, P.

44. Patterned Sol-Gel Structures by Micro Molding in Capillaries, Lochhead, M.J., Yager, P.Y. Abstract 1996 Materials Research Society Fall Meeting.

45. Fluorescence analyte sensing in whole blood based on diffusion separation in silicon-microfabricated flow structures, Weigl, B.H., Hixon, G. T., Yager, P., SPIE Biomedical Optics, San Jose, Fluorescence Sensing Technology III, 1997, submitted.

46. Diffusion-Based Optical Chemical Detection in Silicon Flow Structures, Weigl, B. H. , Holl, M. A., Schutte, D., Brody, J. P., and Yager, P., µTAS 96, Conference Proceedings, accepted.

47. Rapid Sequential Chemical Analysis Using Multiple Fluorescent Reporter Beads, Weigl, B. H. , van den Engh, G. , Kaiser, R., Altendorf, E., and Yager, P., µTAS 96, Conference Proceedings.

48. Micromachining and Microfabrication, Yager, P., 1997 Gordon Research Conference on Bio/Analytical Sensors, 7/27/97-8/1/97, New England College, New Hampshire, invited

49. Microfluidic Chemical Analytical Systems, Yager, P., NIST Chemistry Division Guest Speaker, 1/98, Gaithersburg, MD, invited

50. Design of Microfluidic Sample Preconditioning Systems for Detection of Biological Agents in Environmental Samples, Yager., P. SPIE Micromachining and Microfabrication Symposium, 9/98, Santa Clara, CA, invited

51. Applying Microfluidic Chemical Analytical Systems to Imperfect Samples, Yager, P., µTAS'98, 10/13/98 to 10/16/98, Banff Park Hotel, Alberta, Canada, invited

52. Microfluidic Chemical Analytical Systems, Yager, P., CPAC Applied Science Meeting, 11/2/99, Meany Tower Hotel, invited

53. Microfluidic Chemical Analytical Systems, Yager, P., U.W. Materials Sciences and Engineering Department Seminar, 2/8/99, invited

54. Microfluidic Chemical Analytical Systems, Yager, P., Higuchi Chemical Sciences Center, University of Kansas, 2/22/99, invited

55. Lipid High Axial Ratio Microstructures for Delivery of Therapeutics, Yager, P., UW Nanotechnology Seminar, 3/30/99, invited

56. Microfluidic Chemical Analytical Systems, Yager, P., Zeneca Conference on Microfluidic Applications to Drug Discovery, London, UK, 6/23/99, invited

57. Microfluidic Chemical Analytical Systems, Yager, P., NIH NIGMS Conference on new approaches to metabolism, Bethesda, MD, 9/13/99, invited

58. Host WTC MEMS Workshop, Aljoya/Battelle Conference Center, Seattle, WA 9/15/99, invited.

59. Recent progress in Microfluidic Chemical Analytical Systems, Yager., P. SPIE Micromachining and Microfabrication Symposium, 9/21/99, Santa Clara, CA, invited

60. Recent progress in Microfluidic Chemical Analytical Systems, Yager, P., DARPA combined Composite CAD/MicroFlumes Planning Meeting, Chantilly, VA, 9/27/99, invited

61. Recent progress in Microfluidic Chemical Analytical Systems, Yager, P., Puget Sound Biotechnology Society Forum, Bothell, WA 10/1/99, invited keynote speaker

62. Recent progress in Microfluidic Chemical Analytical Systems, Yager, P., University of Alberta Department of Chemistry, 10/4/99, invited

63. Recent progress in Microfluidic Chemical Analytical Systems, Yager, P., ARBF Annual National Meeting, Belleview, WA, 2/22/00, invited

64. Recent progress in Microfluidic Chemical Analytical Systems, and Complex High Axial Ratio Microstructures for Drug Delivery, Yager, P., Abbott Research Laboratories, Abbott Park, Illinois, 3/17/00, invited

65. Recent progress in Microfluidic Chemical Analytical Systems, Yager, P., Analytica 2000, 4/13/00, Munich, Germany, invited

66. Analytical devices based on transverse transport in microchannels, Yager, P., Cabrera, C., Hatch, A., Hawkins, K., Holl, M., Kamholz, A., Macounova, K., and Weigl, B.H., µTAS 2000, 5/20/00, University of Twente, Enschede, the Netherlands, platform talk

67. Analytical devices based on transverse transport in microchannels, Yager, P., Cabrera, C., Hatch, A., Hawkins, K., Holl, M., Kamholz, A., Macounova, K., and Weigl, B.H.,Gordon Conference on Separation and Purification, 8/10/00, Colby Sawyer College, NH, invited

68. Analytical devices based on transverse transport in microchannels, Yager, P., et al. Texas A&M Department of Chemistry, 3/1/01, College Park, TX, invited

69. Microfluidic Physics Session Chair and introductory remarks, Yager. P., Gordon Conference on the Physics and Chemistry of Microfluidics, 7/28/01, Oxford, UK, invited.

70. Microfluidics—The interface between biomaterials and MEMS, Yager, P., UWEB Symposium, 8/20/01, University of Washington, Seattle, WA, invited

71. Analytical devices based on transverse transport in microchannels, Yager P., et al., CHI BioMEMS and Nanotechnology conference, 9/24/01, Columbus OH, invited and session chair (cancelled)

72. Recent developments in microfluidic devices for chemical and biochemical analysis, Yager P. et al., Chemical Engineering Seminar Series, UW, 10/15/01, invited

73. Cell lysis, protein extraction and enzymatic assay detection in a microfluidic device, Schilling, E., Kamholz, A.E., and Yager, P., µTAS 2001, 10/23/01, Monterey, CA, platform talk.

74. The next steps in the evolution of microfluidics: A common format and robust systems for molecular assembly, Yager, P., DARPA special workshop on Novel Applications of Microfluidics12/13/01, Dulles, VA, invited talk

75. Microfluidic laminate devices for point-of-care diagnostics, Yager, P. et al., 1/31/02, UW Department of Oral Biology, Seattle, WA, invited talk

76. Microfluidic laminate devices for point-of-care diagnostics, Yager, P., 3/25/02, Nanyang Technological University, Singapore, invited seminar

77. Polymeric laminate technology for a rapid diffusion immunoassay, Yager, P. et al., 4/2/02, Materials Research Society Meeting, San Francisco, CA, invited talk

78. A microfluidic sample preconditioning system for chem-bio warfare agent detection and quantification, Yager, P. et al., 4/10/02, BioDefense Mobilization Conference, Seattle, invited talk

79. Diffusion immunoassay (DIA) for protein analytes, Yager, P. and Hawkins, K. et al., 5/4/02, IEEE MMB2002 Meeting, Madison, WI, poster and flash presentation

80. Diffusion immunoassay (DIA) for protein analytes, Yager, P. et al., 4/8/02, Microscale Life Sciences Program seminar, Seattle, invited talk

81. Diffusion immunoassay (DIA) for protein analytes, Yager, P. et al., 6/24/02, Diagnostic Technologies Panel at BECON Meeting, NIH, Bethesda, MD, invited talk and panel session

82. The diffusion immunoassay: a rapid assay in microfluidic and static multi-well formats, Yager, P. et al., 7/29/02, SmallTalk 2002, San Diego, CA, invited talk

83. Microfluidics for low cost medical diagnostics, Yager, P. et al., 9/10/02, Puget Sound AIChE chapter monthly meeting dinner speaker, invited

84. Microfluidic laminate devices for point-of-care diagnostics, Yager, P. et al., 9/17/02, Sandia National Laboratories, Albuquerque, NM, invited

85. Microfluidics for low cost medical diagnostics, Yager, P. et al., 9/18/02, UW Nanotechnology Center’s Nanotechnology Forum, Seattle, invited

86. Microfluidics for low cost medical diagnostics, Yager, P. et al., 10/18/02, Rosetta Inpharmatics, Bothell, WA, invited

87. Microfluidics for low cost medical diagnostics, Yager, P. et al., 11/18/02, UC Irvine Departments of Physiology and Bioengineering, invited

88. Biomaterials questions for low cost microfluidic medical diagnostics Yager, P. et al., 12/19/02, UWEB Meeting in honor of Allan Hoffman’s 70th birthday, Maui, HA, invited

89. Microfluidics and Engineering a New Doctor-Patient Interface, Yager, P., et al., 3/13/03, at Interface between Engineering and Biology and its Impact on the Human Condition, Regional National Academy of Engineering Meeting, Seattle, WA, invited

90. Microfluidics for low cost medical diagnostics, Yager, P. et al., 05/15/03, CHI Mainstreaming Microfluidics Conference, Boston, MA, invited

91. Microfluidics for low cost medical diagnostics, Yager, P. et al., 08/19/03, Hewlett Packard, Corvallis, OR, invited

92. Microfluidics for low cost medical diagnostics, Yager, P. et al., 08/27/03, Gordon Research Conference, Physics and Chemistry of Microfluidics, Big Sky, MT, invited

93. Microfluidics for low cost medical diagnostics, Yager, P. et al., 10/2/03, BMES Meeting, Nashville, TN, invited (and session chair)

94. Microfluidics for low cost medical diagnostics, Yager, P. et al., 10/16/03, School of Dentistry, UW, invited

95. Involvement of University faculty with startup companies, Yager, P., 10/22/03, SSTI Conference, Seattle, WA, invited

96. Microfluidics for low cost medical diagnostics, Yager, P. et al., 10/29/03, Samsung Advanced Institute of Technology, Korea, invited

97. Microfluidics for low cost medical diagnostics, Yager, P. et al., 10/30/03, Joint Korea-Japan Symposium, Korea Advanced Institute of Science and Technology, Korea, invited

98. Microfluidics for low cost medical diagnostics, Yager, P. et al., 10/30/03, Nanobiotechnology Symposium, Hanyang University, Ansan, Korea, invited

99. Microfluidics and nanotechnology for low cost medical diagnostics, Yager, P. et al., 3/04/04, NCI Nanotechnology Symposium, FHCRC, Seattle, WA, invited

100. Microfluidic technology for point-of-care diagnostic systems, Yager, P. et al., 7/15/04, Pacific Northwest Biotechnology Symposium, Seattle, WA, invited

101. Microfluidic technology for point-of-care diagnostic systems, Yager, P. et al., 7/23/04, Hewlett Packard, Corvallis, OR, invited

102. Microfluidics for point-of-care diagnostics, Yager, P., et al., 9/9/04, IBEC 2004 Conference, Singapore, invited

103. Microfluidics for point-of-care diagnostics, Yager, P., et al., 9/10/04, Hewlett Packard Corporation, Singapore, invited

104. Chair session on Microfluidic Diagnostics, 9/30/04, µTAS 2004, Malmö, Sweden, invited

105. Microfluidics for point-of-care diagnostics, Yager, P., et al., 10/11/04, UW Department of Oral Biology, invited

106. Microfluidics for point-of-care diagnostics, Yager, P., et al., 10/21/04, UW Department of Biochemistry, Seattle, WA, invited

107. Microfluidics for point-of-care diagnostics, Yager, P., et al., 10/25/04, UW Department of Oral Biology, Seattle, WA, invited

108. Microfluidics for point-of-care diagnostics, Yager, P., et al., 11/8/04, AIChE Annual Meeting, Austin, TX, invited

109. Microfluidics for point-of-care diagnostics, Yager, P., et al., 11/23/04, Biochemistry Departmental Seminar, UW, Seattle, WA, invited

110. Saliva-based immunoassays for monitoring health status, Yager, P., et al., 2/7/05, Gordon Conference on Salivary Glands and Exocrine Secretions, Ventura, CA, invited

111. Development of microfluidic-based point-of-care diagnostic systems, Yager, P., et al., 07/27/05, Regional Nanotechnology Conference, Portland State University, Portland, OR, invited

112. Session chair on Crossover Techniques, Yager, P., 8/24/05, Gordon Conference on Physical and Chemistry of Microfluidics, Oxford, UK, invited

113. Development of microfluidic-based point-of-care diagnostic systems, Yager, P., et al., 9/29/05, BMES Annual Meeting, Baltimore, MD, invited, and session chair

114. Microfluidic systems for rapid point-of-care immunoassays, Yager, P., et al., 10/15/05, AABB Annual Meeting, Seattle, WA, invited

115. Microfluidics for point-of-care diagnostics, Yager, P., et al., 11/03/05, Student-initiated speaker series, Microfluidics interest group, University of Michigan, Ann Arbor, ME, invited

116. Personalized Medicine and Microfluidics, Yager, P., 11/16/05, Seattle Bio-Tech Alliance Personalized Medicine Symposium, Seattle, WA, invited

117. Microfluidics and Global Health Issues, 2/16/06, Indus Partners Symposium on Global Health, Bellevue, WA, invited

118. Microfluidic POC diagnostics – macro- and micro-views, Yager, P., et al., 2/22/06, CHI Tri-Conference, San Francisco, CA, invited

119. Development of microfluidic-based SPR imaging immunoassays, 3/15/06, Yager, P., et al., PITTCON meeting, Orlando, FA, invited

120. Point of Care Diagnostics for the developed and the developing worlds, 4/3/06, Yager, P., et al., Transdisciplinary Conference on Distributed Diagnosis and Home Healthcare (D2H2), Washington, DC, invited

121. Point of Care Diagnostics for the Developed and the Developing Worlds, 5/23/06, Yager, P., et al., IEEE-EMBS Seattle Chapter, invited

122. Point of Care Diagnostics for the Developed and the Developing Worlds, 5/25/06, Yager, P., et al., Global Health Diagnostics Forum, Seattle, WA, invited

123. Point of Care Diagnostics for the Developing World, 6/13/06, Yager, P., et al., Council on Foreign Relations, New York City, invited

124. Point of Care Diagnostics for the Developed and the Developing Worlds, 7/3/06, Yager, P., et al., Jet Propulsion Laboratory, Pasadena, CA, invited

125. Point of Care Diagnostics for the Developed and the Developing Worlds, 10/11/06, BME-IDEA Meeting, Chicago, IL, invited

126. Point of Care Diagnostics for the Developed and the Developing Worlds, 10/31/06, Wellcome Trust Phenotyping Metabolism Meeting, London, UK, invited

127. Microfluidic Systems for Tropical Disease Detection, 2/27/07, PITTCON, Chicago, IL, invited

128. A Point-of-Care Diagnostic System for the Developing World, 4/17/07, Symposium entitled “Integrated Technology Solutions to Advance Global Health”, Rice University, Houston, TX, invited

129. Point-of-Care Diagnostics Now and Future, 4/20/07, IEEE-EMBS regional meeting, Seattle, WA, invited

130. A Point-of-Care Diagnostic System for the Developing World, 7/27/07, National Meeting of the Centers for STD Research, Seattle, WA, invited

131. Development of a Microfluidic Salivary Diagnostic System for Small Drugs based on SPR imaging., CTSA ITHS Symposium on Salivary Diagnostics, 9/11/07, Seattle, WA, invited

132. Recent Developments in Microfluidic Diagnostics, 9/14/07, Rosetta/Merck, Seattle, WA, invited

133. A Point-of-Care Diagnostic System for the Developing World, 10/7/07, Grand Challenges in Global Health Annual Meeting, Cape Town, South Africa, mandatory

134. Development of a Point-of-Care Diagnostic System for the Developing World, 10/14/07, AVS Annual Meeting, Seattle, WA, invited

135. Job Interview Seminar, 1/3/08, UW Bioengineering Department, invited

136. Point of Care Diagnostics for the Developed and the Developing Worlds, 2/10/08, Department of Chemistry, University of Utah, invited

137. Most Promising Technologies, Technical Challenges, Non-Imaging Approaches, 2/20/08, NCI Strategic Workshop on Cancer Nanotechnology: In-vitro Diagnosis and Prevention, Bethesda, MD, invited

138. Challenges Associated with Developing Diagnostic Technologies for Global Public Health: Development of a Point-of-Care Diagnostic System for the Developing World, 2/22/08, AIMBE Annual Meeting, Washington, DC, invited

139. Point-of-Care Diagnostics for the Developing World, 2/27/2008, UW School of Medicine Department of Laboratory Medicine Grand Rounds, invited (televised on UWTV)

140. Development of Microfluidic Point-of-Care Medical Diagnostic Systems for the Developed and Developing Worlds, 3/12/08, MSB2008, Berlin, Germany, invited

141. Point-of-Care Diagnostics for the Developing World, 4/02/2008, Michael Smith Laboratory, UBC, Vancouver, Canada, invited

142. Point-of-Care Diagnostics for the Developing World, 4/17/2008, AACC Oak Ridge Conference, San Jose, CA, invited

143. Point-of-Care Diagnostics for the Developing World, 4/24/2008, Department of Bioengineering, University of Virginia, invited

144. Point-of-Care Diagnostics for the Developing World, 5/7/2008, Molecular Medicine Lecture, invited (televised on UWTV)

145. Needs Assessment & Design of Products Addressing Clinical Needs in Developing Countries, 7/28/2008, AACC Annual Meeting, DC, invited

146. Point of Care Diagnostics and Global Health, Minisymposium Chair and speaker IEEE-EMBC Meeting, Vancouve, BC, Canada, 8/24/2008, invited

147. Microfluidics Meets Surface Plasmon Resonance Imaging—New Bioanalytical Methods, Panomino 2008, 9/06/2-008, Friday Harbor, WA, invited

148. SaliSense—Salivary Diagnostics of Psychoactive Drugs, Launchpad, 9/12/2008, Seattle, WA, invited

149. Point of Care Diagnostics and Global Health, Session co-chair and speaker, BMES Meeting, St. Louis, MO, 9/2/2008, invited

150. Point-of-Care Diagnostics for the Developing World, 11/20/2008, Tulane University Department of Biomedical Engineering, New Orleans, LA, invited

151. Point-of-Care Diagnostics for the Developing World, 11/24/2008, Science on Tap, Seattle, WA, invited

152. Point-of-Care Diagnostics Work in the Yager Group at University of Washington, 12/11/2008, TATRC DoD Mobile Health Summit, McLean, VA, invited

153. A Microfluidic Point-of-Care Diagnostic System for the Developing World, 1/26/09, ALA Annual Meeting, Palm Springs, CA, invited

154. Point-of-Care Diagnostics for the Developing World, 1/29/2009, Naval Research Laboratory, Washington, DC, invited

155. Combining Microfluidic Immunoassays with SPR Imaging for Detection of Small Molecules in Saliva, 3/10/2009, Emerging Biomedical Detection Technologies, PITTCON, Chicago, IL, panel and invited talk

156. Micro Total Analysis Systems (µTAS) (and an example thereof), 4/1/2009, Johnson Space Center, NASA, Houston, TX, invited

157. A Microfluidic Point-of-Care Diagnostic System for the Developing World, 4/14/2009, MEDEX Grand Rounds, UW, Seattle, WA, invited

158. A Microfluidic Point-of-Care Diagnostic System for the Developing World, and Session Chair, 6/30/2009, Physics and Chemistry of Microfluidics Gordon Conference, Lucca/Barga, Italy, invited (elected to run 2013 conference)

159. Bioengineering and Microfluidics for Medical Diagnostics, 7/28/2009, College of Engineering Math Academy, invited

160. A Microfluidic Point-of-Care Diagnostic System for the Developing World,, 8/27,2009, BEIT Symposium, Seattle, invited

161. Annual report to the Gates Foundation, 10/21/2009, Arusha, Tanzania, required

162. Panel on Washington Technology Commercialization, 12/02/2009, Seattle Convention Center, Seattle, invited

163. Microfluidics for Point-of-Care Diagnostic Systems, 1/21/2010, BioE Soirée, Foege Hall, invited

164. Microfluidics for Point-of-Care Diagnostic Systems in the Developing World, 2/2/2010, College of Engineering, Northeastern University, Boston, invited

165. Microfluidics for Point-of-Care Diagnostic Systems in the Developing World, 2/5/2010, Dept. of Biomedical Engineering, UC Irvine, CA, invited

166. New Low-Cost Diagnostic Technologies to Improve Global Health, 3/2/2010, PITTCON conference, Orlando, FL, invited

167. New Low-Cost Diagnostic Technologies to Improve Global Health, 3/17/2010, Lectures at the Leading Edge, College of Engineering, University of Toronto, Canada, invited

168. New Low-Cost Diagnostic Technologies to Improve Global Health, 3/23/2010, Symposium on Chemistry and the Developing World, ACS Meeting, San Francisco, CA, invited

169. New Low-Cost Diagnostic Technologies to Improve Global Health, 4/13/2010, MESA+ Institute, University of Twente, Enschede, the Netherlands, invited

170. A Point of Care Diagnostic System for the Developing World, 4/22/2010, Micro/Nano-technology Lecture Series, RLI, MIT, Cambridge, MA, invited

171. Panel on Widely Accessible Diagnostics, 5/4/2010, Bio2010 Meeting, Chicago, IL, invited

172. Microfluidics for Point-of-Care Diagnostics, 6/15/2010, DARPA Uncultured Microbes workshop, Seattle, WA, invited

173. Microfluidics for Point-of-Care Diagnostic Systems, 6/22/2010, Gordon Conference on Bioanlytical Sensors, New London, NH, invited

174. Microfluidics for Point-of-Care Diagnostic Systems, 7/7/2010, Neurosurgery Grand Rounds, Harborview Hosptital, Seattle, WA, invited

175. Report on progress of ARRA Grant, 8/3/2010, NIBIB Headquarters, Bethesda, MD, invited

176. Microfluidics for Point-of-Care Diagnostic Systems, 8/4/2010, Naval Research Laboratory, Washington, DC, invited

177. Global Health at the UW Department of Bioengineering, 9/21/2010, CUGH Symposium, Seattle, WA, invited

178. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 9/30/10, Procter and Gamble Lecture, Chemistry Department, University of Massachusetts, Amherst, MA, invited

179. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 10/1/10, GE Global Research Laboratory, Niskayuna, NY, invited

180. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 10/5/10, Kidney Research Institute, Seattle, WA, invited

181. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 10/14/10, Small Nucleic Acids Workshop, FHCRC, Seattle, WA, invited

182. Final report to the Gates Foundation on the DxBox Project, 10/27/2010, Seattle, WA, required

183. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 11/1/10, CPAC Annual Meeting, Seattle, Hotel Deca, WA, invited

184. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 11/18/10, Lab on a Chip Applications session, IMECE/ASME Congress, Vancouver, BC, Canada, invited

185. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 11/29/10, Biomedical Engineering Department, USC, Los Angeles, CA, invited

186. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 12/10/10, UC Berkeley Global Health Diagnostics Innovation Summit, UC Berkeley, Berkeley, CA, invited

187. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 12/17/10, Microfluidic and Nanofluidic Devices for Chemical and Biochemical Experimentation, Pacifichem Conference, Honolulu, HI, invite

188. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 1/21/11, UW-KNU Joint Symposium on Convergence Technology in Medicine, KNU Medical School, Daegu, South Korea, invited

189. Microfluidics 2.0—a Biomaterials Challenge, 2/7/2011, UWEB 21 Symposium Honoring Thomas Horbett, Seattle, WA, invited

190. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 2/17/11, DTRA Center for Biosecurity special meeting on POC Diagnostics, Baltimore, MD, invited

191. Microfluidics 2.0: Development of 2-Dimensional Paper Networks for POC Diagnostics, 3/13/11, PITTCON 2011 session on Paper Based POC analytical kits, Atlanta, GA, invited

192. Microfluidics 2.0: Development of 2-Dimensional Paper Networks for POC Diagnostics, 3/16/11, PITTCON 2011 session on Nano and Microfluidic Systems in Bioanalysis, Atlanta, GA, invited

193. Microfluidics 2.0: Development of 2-Dimensional Paper Networks for POC Diagnostics, 5/9/11, guest lecture in EPI590 Introduction to Laboratory Methods in Population Health, FHCRC, Seattle, WA, invited

194. Vice Chair, GRC on the Physics and Chemistry of Microfluidics, 6/26/11 to 7/1/11, Waterville Valley Resort, Waterville Valley, NH, invited

195. Microfluidics 2.0: 2-Dimensional Paper Networks for POC Diagnostics in the Developed and Developing Worlds, 8/8/11, DTRA/DRDE Workshop on Chemical and Biological Defence Science and Technology, Gwalior, India, invited

196. Microfluidics 2.0: Reducing the costs for diagnostic tests and screening, 8/22/11, NCI Symposium on Cancer Detection and Diagnostics Technologies for Global Health, Bethesda, MD, talk and poster and demonstration, invited

197. Microfluidics 2.0: Low Cost Microfluidic Systems for POC Diagnostics in the Developed and Developing Worlds, 9/8/11, International Workshop on Microsystems Technologies for African Health (µ-Med-A 2011), Mpumalanga, South Africa, invited

198. Microfluidics 2.0—making point-of-care testing extremely inexpensive, and what that could mean for global health, 9/28/11, Guest lecturer at IHME, Seattle, WA, invited

199. Capillarity-Based Microfluidics for Bioanalysis, 10/1/11, Hosted and gave opening talk at first Capillarity-Based Microfluidics for Bioanalysis, Seattle, WA, hosted

200. A two-dimensional paper network (2DPN) for comprehensive dengue detection at the point of care 10/6/11, µTAS 2011, Seattle, WA, invited

201. Microfluidics 2.0: Low Cost Microfluidic Systems for POC Diagnostics in the Developed and Developing Worlds, 12/2/11, Columbia University, Department of Biomedical Engineering, invited

202. Immunoassay Signal Amplification Using 2-Dimensional Paper Networks (2DPN), 3/2/12, PITTCON 2012 session on Bioanalytical Microfluidics and Emerging Nanotechnologies, Orlando, FL, invited

203. Microfluidics 2.0: Technology for Decentralizing Medical Diagnostics, 3/21/12, WBBA “Mobilizing Miracles” conference, Microsoft Conference Center, Redmond, WA, invited

204. New Ultra-low-Cost POC Diagnostics, and How They Could Change the Way We Do Disease Surveillance. 4/21/12, Northwest PRECEDENT Meeting, Seattle, WA, invited

205. Microfluidics 2.0: Technology for Decentralizing Medical Diagnostics, 4/29/12, Western Regional Global Health Association meeting, UW, Seattle, Redmond, WA, invited

206. Development of point-of-care medical assays in paper, 6/25/12, Point-of-Care Diagnostics Workshop, Nairobi, Kenya, invited

207. Microfluidics 2.0: Technology for Decentralizing Medical Diagnostics, 7/19/12, International POSTECH Biomedical Device Workshop, POSTECH, Pohang, Korea, invited

208. Design of Low-Cost Instrument-Free Point-of-Care Diagnostics based on Porous Media, 7/24/12, Lab on Chip Summer Workshop, KIST Europe, Saarbrücken, Germany, invited

209. Sophisticated point-of-care devices based on 2D paper networks, 7/27/12, EMBL Conference: Microfluidics 2012, Heidelberg, Germany, invited

210. Sophisticated point-of-care devices based on 2D paper networks, A*STAR Scientific Conference 2012—Integration and Convergence, Sentosa Conference Center, Singapore, 10/19/12, Singapore, invited

211. Sophisticated point-of-care devices based on 2D paper networks, Department of Biomedical Engineering, Georgia Tech, Atlanta, GA, 10/24/12, invited

212. Enabling Sensitive Paper-based Immunoassays and Nucleic Acid Tests, BMES 2012, Atlanta, GA, 10/25/12, invited

213. Enhanced Protein-Based Assays for Detection of Influenza Using Disposable Paper-Based Microfluidic Devices (2DPN), in session on Portable Miniaturized Analytical System for Biochemical Analysis, PITTCON 2013, Philadelphia, PA, 3/19/13, invited

214. Nucleic-Acid-Based Detection of Bacterial Infections Using a Fully-Disposable Paper-Based Microfluidic Technology (2DPN), in session on Emerging Diagnostic Technologies for Resource-Limited Countries, PITTCON 2013, Philadelphia, PA, 3/20/13, invited

215. Sophisticated Point-of-Care Diagnostic Devices Based on 2D Paper Networks, Department of Biomedical Engineering, Texas A&M, College Station, TX, 4/1/13, invited

216. Sophisticated Point-of-Care Diagnostic Devices Based on 2D Paper Networks, Department of Bioengineering, Rice University, Houston, TX, 4/2/13, invited

217. Sophisticated Point-of-Care Diagnostic Devices Based on 2D Paper Networks, WBBA Mobilizing Miracles meeting, Seattle, WA, 4/10/13, invited

218. UW Department of Bioengineering and POC Diagnostics, Keiretsu Life Sciences Group, Seattle, WA, 5/14/13, invited

219. Sophisticated point-of-care diagnostic devices based on 2D paper networks, Microfluidics in Biomedical Sciences Training Program Symposium keynote talk, University of Michigan, Anne Arbor, MI, 5/20/13, invited

220. Co–Chair Gordon Research Conference on the Physics and Chemistry of Microfluidics, Il Ciocco, Lucca-Barga, Italy, 6/8/13 – 6/14/13

221. Sophisticated point-of-care diagnostic devices based on 2D paper networks, joint UW/GE symposium, University of Washington, Seattle, WA, 6/24/13, invited

222. Sophisticated point-of-care diagnostic devices based on 2D paper networks, 11th NAMIS workshop, Seattle, WA, 7/8/13, invited

 

 

 


UW GRANT HISTORY:

National Science Foundation, Division of Chemical, Biochemical, and Thermal Engineering, CBT-8717990, "Morphological Properties of Dispersions of Tubule-Forming Phospholipids"; 8/87 - 9/88; $30,000.

Graduate School Research Fund, "Measurement of Alamethicin Activity in Asymmetric Polymerizable Bilayers; 1/88 - 12/88; $8,193.

Graduate School Research Fund Project Support, "Ion Translocation in Asymmetric Polymerizable Bilayers"; 1/89 - 12/90; $6,341.

National Science Foundation, Division of Chemical, Biochemical, and Thermal Engineering, CTS-8815027, "Structure and Formation of Lipid Tubules"; 20%; 1/89 - 6/92 (3 years plus 6 month no cost extension); $210,262 direct total.

Graduate School Research Fund Equipment Support, "NIH Small Instrumentation Award #5 (to purchase a Perkin-Elmer LS-5B Luminescence Spectrometer; 4/89; $18,310

Washington Technology Center; WTC 09-1044 (first award with this budget number), "Microbiosensor Research"; 7/89 - 6/91; $90,302.

Johnson & Johnson Corporation, "Development of a Portable Fiber Optic Anesthetic Monitoring System"; 11/89 - 2/90; $10,000.

National Science Foundation, IID, BBS SGER Program, "Toward a practical assay for ion channel activity: Can a silicon device support planar lipid bilayers?"; 10/90 - 9/91 plus 6 month extension ; $40,323 total direct .

Graduate School Research Fund BRSG Project Support, "Recognition of Subvocalization EEG by Neural Networks"; 2/91 - 1291; $7,910

Johnson and Johnson Corporation, Corporate Office of Science and Technology, "Possible improvement of biocompatibility of biomaterials by immobilizing phospholipids on their surfaces" (gift to Prof. Allan S. Hoffman and myself); 8/91 - 7/92 (one year); $33,000 direct.

Washington Technology Centers, WTC #09-1044, "Microbiosensor Research"; 15%; 7/91 - 6/93 (two years); $73,000 direct total.

Washington Technology Centers, with Robert Kaiser as Co-PI, WTC #63-1726, "Microfabricated devices for Clinical Chemistry"; 15%; 7/93 - 6/95 (two years); $41,500 direct total

With Prof. Christopher Viney at UW as PI, Yager as Co-PI., National Science Foundation Materials Synthesis and Processing Initiative, "Spinning natural and genetically engineered silk: Advancing liquid crystalline polymer technology" ; 7/92 - 6/95 (three years with additional extension to present); $304,898 total direct, most of which ultimately went to the Yager laboratory.

National Science Foundation BES-9309041 "Raman-Based Fiber Optic Sensor for Anesthetics", 7/93-6/96, $160,502 direct in three years.

University of Washington Royalty Research Fund "Self-Organization of Lipopeptides: Potential Antifungal, Antibacterial and Antitumor Agents", 3/94 - 2/95, $20,000 direct.

DARPA/U.S. Army - Grant #: DAMD17-94-J-4460, Yager as PI, "Development of a Miniaturized Clinical Chemistry Monitor", 20%, 9/94-9/96 , $800,000 Total direct

Senmed Medical Ventures/Micronics, Inc. - 63-2530 UW budget, Yager as PI, Silicon Microfabrication of Optical Devices for Biomedical Assays, 15%, 7/94 - present (open ended) ~$1,570,835 total to date

The Whitaker Foundation "Self-Assembled Prodrug Tubules for Continuous Release", with Mike Gelb of Chemistry as Co-PI, 7/95-6/99, $997,959 total, divided 50/50 with Gelb

Defense Advanced Research Projects Agency, "A Micro-Fluidic Sample Preconditioning System for CBW Agent Detection and Quantification", 5/97-7/00, $ 1,604K total, shared with Co-PI Fred Forster

College of Engineering, "Center for Applied Microtechnologies", 7/97- 5/00 , ~$75K/year total, shared with R.B. Darling, Co-PI

Washington Technology Center, Evaluation of Microfluidic Mixing Strategies for Point-of-Care Diagnostics, WTC RTP project, 1/00-12/01, $72K total

Micronics, Inc., Evaluation of Microfluidic Mixing Strategies for Point-of-Care Diagnostics, WTC RTP project, 1/00-12/01, $24K total

Mesosystems, Inc., "Development of isoelectric focusing for detection of CBW agent" Phase I SBIR subcontract, 4/00 to 8/00, $30K total.

Abbott Laboratories, Hospital Products Division, "Development of tubule-based drug delivery", 6 months, 7/1/00 - 9/30/00, $24K total

NIH NCRR, "Development of Microfluidic Diffusion Immunoassay (DIA)", 4 years, $1M total, 5/01- 4/05

Mesosystems, Inc., "Development of isoelectric focusing for detection of CBW agent" Phase II Fast Track SBIR subcontract, 4/01-3/03, ~$128K total

Singapore National Science and Technology Board, Singapore UW Alliance, 5 years, 5/02 – 4/07, amount confidential

MesoSystems, Inc., "Development of isoelectric focusing extraction and concentration of DNA" Phase II SBIR subcontract, 10/02-09/03, ~$65K total

NIH NIDCR, “Rapid parallel salivary immunoassays on a disposable”, 4 years, 9/02 – 8/06, $3.8M total

NIH NIBIB, “Microfluidic Technology for Gene Delivery Systems” (Kenneth Longmuir, UC Irvine, PI), 9/15/03-09/14/08, $433K total

Hewlett Packard Corporation, “Printing Functional Proteins”, 9 months, 12/03 – 8/04, $75K total

NIH NIAID, “1 U01 AI61187-01 -- A multiplex, point-of-care test for enteric pathogens” (Bernhard Weigl, PATH, PI), 9/04 – 8/08, ~$465K total to PY lab

NASA, Development of a DNA-Based Detector Array for Microbial Monitoring of the ISS Water System (David Stahl, PI), 1/05 – 12/07, $486K total to PY lab

The Bill and Melinda Gates Foundation, Grand Challenges in Global Health, “A Point-of-Care Diagnostic System for the Developing World”, 5 years, $15.4M total, 7/05 –6/10

Coulter Foundation Translational Research Partnership, “Revolutionizing the monitoring of therapeutic drugs, phase I: clinical demonstration of antiepileptic drug monitoring using saliva”, 1 year, $99K direct

WRF, Gift in support of Salivary Diagnostics project, 7/07 – 12/07, $50K direct

UWTT TGIF Program, “Revolutionizing Monitor of Therapeutic Drugs: Multipliexed monitoring of Antiepileptic Drugs in Saliva”, 1/08-1/09, $49.5K Direct

Microsoft Research, “Enabling Community Health Workers with Mobile Phones” (Gaetano Borriello, PI), 1/08-1/09, ~$20K Direct to Yager lab

NIH, subcontract for 1 RA under “Responsive Biopolymers”, (Patrick Stayton, PI) 9/08 – 8/13, ~$350K Direct

NIH NIBIB 1RC1EB010593-01 (ARRA Challenge Grant), “A sensitive multiplexed diagnostic platform using disposable 2D paper networks”, 10/09-9/11, $1M total

BigTek, Inc., Development of a sample conditioning system for sputum-based detection of tuberculosis, (Karl Böhringer, PI), 9/09-10/08, $100K total

DARPA DSO, Low-Cost Rapid Multiplexed Diagnostics for Emerging Diseases, 12/10 – 9/11, ~$450K total

NIH NIAID, “A high-sensitivity low-cost multiplexed immunoassay platform based on 2-dimensional paper network; demonstration using influenza”, 7/11 – 6/16, $5.8M total

DARPA, “Multiplexable Autonomous Disposables for Nucleic Acid Amplification Tests for Limited Resource Settings”, 9/11 – 8/16, $13.6 awarded through 8/14


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revised 8/7/2013