Ellen M. Wijsman

Manuscripts in refereed journals

Lee W-P, et al. (2024) Association of Common and Rare Variants with Alzheimers Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimers Disease Sequencing Project. Alzheimers & Dementia (in press).

Xicota L,Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S; LongżLife Family Study (LLFS); Alzheimer's Disease Genetic Consortium (ADGC); Alzheimer's Biomarkers ConsortiumżDown Syndrome (ABCżDS). Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimer's Dementia 20(4):2670-2679. doi: 10.1002/alz.13718.

Leung YY, Naj AC, Chou YF, Valladares O, Schmidt M, Hamilton-Nelson K, Wheeler N, Lin H, Gangadharan P, Qu L, Clark K, Kuzma AB, Lee WP, Cantwell L, Nicaretta H; Alzheimer's Disease Sequencing Project; Haines J, Farrer L, Seshadri S, Brkanac Z, Cruchaga C, Pericak-Vance M, Mayeux RP, Bush WS, Destefano A, Martin E, Schellenberg GD, Wang LS. (2024) Human whole-exome genotype data for Alzheimer's disease. Nature Communications. 15(1):684. PMCID: PMC10805795. doi: 10.1038/s41467-024-44781-7.

Horimoto ARVR, Boyken LA, Blue EE, Grinde KE, Nafikov RA, Sohi HK, Nato AQ, Bis JC, Brusco LI, Morelli L, Ramirez A, Dalmasso MC, Temple SD, Satizabal C, Browning SR Seshadri S, Wijsman EM, Thornton TA (2023) Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer's disease in Hispanic and Latino populations. Human Genetics and Genomics Advances.4:100207. DOI: 10.1016/j.xhgg.2023.100207.

Rahman-Filipiak A, Bolton C, Grill JD, Rostamzadeh A, Chin N, Heidebrink J, Getz S, Fowler NR, Rosen A, Lingler J, Wijsman E, Clark L for the Advisory Group on Risk Evidence Education in Dementia (AGREED) (2023) Biomarker disclosure protocols in prodromal Alzheimer's disease clinical trials. Alzheimer's & Dementia. 19(9):4270-4275, DOI: 10.1002/alz.13380.

Rosen AC, Arias JJ, Ashford JW, Blacker D, Chhatwal JP, Chin NA, Clark L, Denny SS, Goldman JS, Gleason CE, Grill JD, Heidebrink JL, Henderson VW, Lavacot JA, Lingler JH, Menon M, Nosheny RL, Oliveira FF, Parker MW, Rahman-Filipiak A, Revoori A, Rumbaugh MC, Sanchez DL, Schindler SE, Schwarz CG, Toy L, Tyrone J, Walter S, Wang L-S, Wijsman EM, Zallen DT, Aggarwal NT, and members of AGREEDementia (2022) The Advisory Group on Risk Evidence Education for Dementia: Multidisciplinary and Open to All. Journal of Alzheimer's Disease. 90(3):953-962. PMC9901285, doi:10.3233/JAD-220458.

Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcón-Martan E, Alcolea D, Alegret M, Alvarez I, Ălvarez V, Armstrong NJ, Tsolaki A, Antúnez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Bossů P, Brĺthen G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, Bűrger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo Á, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen JAHR, Clark C, Conti E, Corma-Gómez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, Denning N, DeStefano A, Dichgans M, Diehl-Schmid J, Diez-Fairen M, Rossi PD, Djurovic S, Duron E, Düzel E, Dufouil C, Eiriksdottir G, Engelborghs S, Escott-Price V, Espinosa A, Ewers M, Faber KM, Fabrizio T, Nielsen SF, Fardo DW, Farotti L, Fenoglio C, Fernández-Fuertes M, Ferrari R, Ferreira CB, Ferri E, Fin B, Fischer P, Fladby T, Fließbach K, Fongang B, Fornage M, Fortea J, Foroud TM, Fostinelli S, Fox NC, i Franco-Macías E, Bullido MJ, Frank-García A, Froelich L, Fulton-Howard B, Galimberti D, García-Alberca JM, García-González P, Garcia-Madrona S, Garcia-Ribas G, Ghidoni R, Giegling I, Giorgio G, Goate AM, Goldhardt O, Gomez-Fonseca D, González-Pérez A, Graff C, Grande G, Green E, Grimmer T, Grünblatt E, Grunin M, Gudnason V, i Guetta-Baranes T, Haapasalo A, Hadjigeorgiou G, Haines JL, Hamilton-Nelson KL, Hampel H, Hanon O, Hardy J, Hartmann AM, Hausner L, Harwood J, Heilmann-Heimbach S, Helisalmi S, Heneka MT, Hernández I, Herrmann MJ, Hoffmann P, Holmes C, Holstege H, Vilas RH, Hulsman M, Humphrey J, Biessels GJ, Jian X, Johansson C, Jun GR, Kastumata Y, Kauwe J, Kehoe PG, Kilander L, Stĺhlbom AK, Kivipelto M, Koivisto A, Kornhuber J, Kosmidis MH, Kukull WA, Kuksa PP, Kunkle BW, Kuzma AB, Lage C, Laukka EJ, Launer L, Lauria A, Lee CY, Lehtisalo J, Lerch O, Lleó A, Longstreth W Jr, Lopez O, de Munain AL, Love S, Löwemark M, Luckcuck L, Lunetta KL, Ma Y, Macías J, MacLeod CA, Maier W, Mangialasche F, Spallazzi M, Marquié M, Marshall R, Martin ER, Montes AM, Rodríguez CM, Masullo C, Mayeux R, Mead S, Mecocci P, Medina M, Meggy A, Mehrabian S, Mendoza S, Menéndez-González M, Mir P, Moebus S, Mol M, Molina-Porcel L, Montrreal L, Morelli L, Moreno F, Morgan K, Mosley T, Nöthen MM, Muchnik C, Mukherjee S, Nacmias B, Ngandu T, Nicolas G, Nordestgaard BG, Olaso R, Orellana A, Orsini M, Ortega G, Padovani A, Paolo C, Papenberg G, Parnetti L, Pasquier F, Pastor P, Peloso G, Pérez-Cordón A, Pérez-Tur J, Pericard P, Peters O, Pijnenburg YAL, Pineda JA, Pińol-Ripoll G, Pisanu C, Polak T, Popp J, Posthuma D, Priller J, Puerta R, Quenez O, Quintela I, Thomassen JQ, Rábano A, Rainero I, Rajabli F, Ramakers I, Real LM, Reinders MJT, Reitz C, Reyes-Dumeyer D, Ridge P, Riedel-Heller S, Riederer P, Roberto N, Rodriguez-Rodriguez E, Rongve A, Allende IR, Rosende-Roca M, Royo JL, Rubino E, Rujescu D, Sáez ME, Sakka P, Saltvedt I, Sanabria Á, Sánchez-Arjona MB, Sanchez-Garcia F, Juan PS, Sánchez-Valle R, Sando SB, Sarnowski C, Satizabal CL, Scamosci M, Scarmeas N, Scarpini E, Scheltens P, Scherbaum N, Scherer M, Schmid M, Schneider A, Schott JM, Selbćk G, Seripa D, Serrano M, Sha J, Shadrin AA, Skrobot O, Slifer S, Snijders GJL, Soininen H, Solfrizzi V, Solomon A, Song Y, Sorbi S, Sotolongo-Grau O, Spalletta G, Spottke A, Squassina A, Stordal E, Tartan JP, Tárraga L, Tesí N, Thalamuthu A, Thomas T, Tosto G, Traykov L, Tremolizzo L, Tybjćrg-Hansen A, Uitterlinden A, Ullgren A, Ulstein I, Valero S, Valladares O, Broeckhoven CV, Vance J, Vardarajan BN, van der Lugt A, Dongen JV, van Rooij J, van Swieten J, Vandenberghe R, Verhey F, Vidal JS, Vogelgsang J, Vyhnalek M, Wagner M, Wallon D, Wang LS, Wang R, Weinhold L, Wiltfang J, Windle G, Woods B, Yannakoulia M, Zare H, Zhao Y, Zhang X, Zhu C, Zulaica M; EADB; GR@ACE; DEGESCO; EADI; GERAD; Demgene; FinnGen; ADGC; CHARGE, Farrer LA, Psaty BM, Ghanbari M, Raj T, Sachdev P, Mather K, Jessen F, Ikram MA, de Mendonça A, Hort J, Tsolaki M, Pericak-Vance MA, Amouyel P, Williams J, Frikke-Schmidt R, Clarimon J, Deleuze JF, Rossi G, Seshadri S, Andreassen OA, Ingelsson M, Hiltunen M, Sleegers K, Schellenberg GD, van Duijn CM, Sims R, van der Flier WM, Ruiz A, Ramirez A, Lambert JC (2022) New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4):412-436. PMC9005347, doi: 10.1038/s41588-022-01024-z.

Ma Y, Jun GR, Zhang X, Chung J, Naj AC, Chen Y, Bellenguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Bis JC, Debette S, DeStefano AL, Fornage M, Nicolas G,van Duijn C, Bennett DA, De Jager PL, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert JC, Schellenberg GD, Lunetta KL, Farrer LA; Alzheimer's Disease Sequencing Project and Alzheimer's Disease Exome Sequencing-France Project (2019) Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. JAMA Neurol, 76(9):1099-1108, PMC6563544, doi: 10.1001/jamaneurol.2019.1456.

Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto- Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD, Morrison RS, Rhoads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, and Jayadev J. (2019) Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Annals of Clinical and Translational Neurology. 10;6(4):762-777. PMC6469258. doi: 10:1002/acn3.755.

Zhang X, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, Farrell JJ, Chung J; Alzheimer's Disease Sequencing Project, Mayeux R, Haines JL, Schellenberg GD, Pericak-Vance MA, Lunetta KL, Farrer LA (2019). A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease. Alzheimers Dement. 15(3):441-452. PMC6408965. doi: 10.1016/j.jalz.2018.10.005.

Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Murcia JDG, Lopez OL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Kauwe JK, Lunetta KL, Farrer LA, the Alzheimer's Disease Sequencing Project (2019) Association of rare coding mutations with Alzheimer disease and other dementias among adults of European ancestry. JAMA Network Open 2(3):e191350, PMC6450321, doi: 10.1001/jamanetworkpen.2019.1350.

Ullah E, Mall R, Abbas MM, Kunji K, Nato Jr AQ, Bensmail H, Wijsman EM, Saad M (2019) Comparison and assessment of family- and population-based genotype imputation methods in large pedigrees. Genome Research 29(1):125-134. PMC6314157, DOI: 10.1101/gr.236315.118.

Saad M and Wijsman EM (2019) Association score testing for rare variants and binary traits in family data with shared controls. Briefings in Bioinformatics, 20(1):245-253. PMC6357552, doi: 10.1093/bib/bbx107.

Ullah E, Kunji K, Wijsman EM, Saad M (2019) GIGI2: A fast approach for parallel genotype imputation in large pedigrees. bioRxiv preprint doi: https://doi.org/10.1101/533687.

Beecham G, Vardarajan B, Blue E, Bush WS, Jaworski J, Barral S, DeStefano A, Hamilton-Nelson K, Kunkle B, Martin E, Naj A, Rajabli F, Reitz C, Thornton T, van Duijn CM, Goate A, Seshadri S, Farrer L, Boerwinkle E, Schellenberg G, Haines J, Wijsman E, Mayeux R, and Pericak-Vance MA (2018) Rare genetic variation implicated in Non-Hispanic White families with Alzheimer disease. Neurology: Genetics 4(6):e286, PMC6278241, doi: 10.1038/s41380-018-0112-7.

Chapman NH, Bernier RA, Webb SJ, Munson J, Blue EM, Chen D-H, Heigham E, Raskind WH, Wijsman EM (2018) Replication of a risk haplotype on 1p36.33 for autism spectrum disorder. Human Genetics 137(10):807-815, PMC6309233, DOI: 10.1007/s00439-018-1939-3.

Nafikov RA, Nato Jr AQ, Sohi H, Wang B, Brown L, Horimoto AR, Vardarajan BN, Barral SM, Tosto G, Mayeux RP, Thornton TA, Blue E, and Wijsman EM (2018) Analysis of Pedigree Data in Populations with Multiple Ancestries: Strategies for Dealing with Admixture in Caribbean Hispanic Families from the ADSP. Genetic Epidemiology 42:500-515, DOI: 10.1002/gepi.22133, PMC6160322.

Blue E, Yu C-E, Thornton T, Chapman N, Kernfeld E, Jiang N, Schively K, Buckingham K, Marvin CT, Bamshad M, Bird T, Wijsman E (2017) Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease. Genes, Brain and Behavior 17(6):e12429, doi: 10.1111/gbb.12429, PMC5902667.

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Mřller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Juliŕ A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Břrglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra J, Mayoral F, Schofield PR, Cichon S, Mühleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer TFM, Forstner AJ, Streit F, Baune BT, Air T, Sinnamon G, Wray NR, MacIntyre DJ, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp CM, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li QS, Nauck M, Schoevers RA, Beekman AT, Knowles JA, Viktorin A, Arnold P, Barr CL, Bedoya-Berrio G, Bienvenu OJ, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks EM, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna GL, Hartmann A, Hirschtritt ME, Hoekstra PJ, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon GJ, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel EC, Mir P, Nestadt G, Nicolini H, Okun MS, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter MA, Riddle MA, Robertson MM, Roessner V, Rosário M, Samuels JF, Sandor P, Stein DJ, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland JR, Wolanczyk T, Worbe Y, Zai G, Goes FS, McLaughlin N, Nestadt PS, Grabe HJ, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong SA, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kucinskas V, Lee Chee Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy KC, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders AR, Schall U, Schwab SG, Sim K, So HC, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman PV, Henskens F, Mattingsdal M, Oh SY, Scott R, Webb B, Breen G, Churchhouse C, Bulik CM, Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kendler KS, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM, Schott JM, Anney R, Elia J, Grigoroiu-Serbanescu M, Edenberg HJ, Murray R. (2018) Analysis of shared heritablity in common disorders of the brain. Science 360(6395):eaap8757, DOI:10.1126/science.aap8757, PMC6097237.

Naj A, Lin H, Vardarajan BN, White S, Lancour D, Ma Y, Schmidt M, Sun F, Butkiewicz M, Bush WS, Kunkle BW, Malamon JS, Amin N, Choi SH, Hamilton-Nelson KL, van der Lee S, Gupta N, Koboldt DC, Saad M, Wang B, Nato Jr AQ, Sohi HK, Kuzma A, Wang L-S, Cupples LA, van Duijn C, Seshadri S, Schellenberg GD, Boerwinkle E, Bis J, Dupuis J, Salerno WJ, Wijsman EM, Martin ER, DeStefano AL, Alzheimer's Disease Sequencing Project (2018) Quality Control and Integration of Genotypes from Two Calling Pipelines for Whole Genome Sequence Data in the Alzheimer's Disease Sequencing Project. Genomics S0888-7543(18)30281-30287, DOI:10.1016/j.ygeno.2018.05.004, PMC6397097.

Vardarajan BN, Barral S, Jaworski J, Beecham GW, Blue E, Tosto G, Reyes-Dumeyer D, Medrano M, Lantigua R, Naj A, Thornton T, DeStefano A, Martin E, Wang L-S, Brown L, Van Duijn C, Goate A, Farrer L, Haines JL, Boerwinkle E, Schellenberg G, Wijsman E, Pericak-Vance MA, Mayeux R. For The Alzheimer's Disease Sequencing Project (2018) Whole Genome Sequence Analysis of Caribbean Hispanic Families with Late-onset Alzheimer's Disease. Annals of Clinical and Translational Neurology 5(4):406-417, DOI:10.1002/acn3.537, PMC5899906.

Kunji K, Ullah E, Nato AQ Jr, Wijsman EM, Saad M (2018) GIGI-Quick: A fast approach to impute missing genotypes in genome-wide association family data. Bioinformatics 34(9):1591-1593, doi: 10.1093/bioinformatics/btx782, PMC5925782.

Blue E, Bis J, Dorschner M, Tsuang D, Barral S, Beecham G, Below J, Bush W, Butkiewicz M, Cruchaga C, DeStefano A, Farrer L, Goate A, Haines J, Jaworski J, Jun G, Kunkle B, Kuzma A, Lee J, Lee K, Lunetta K, Ma Y, Martin E, Naj A, Nato A, Navas P, Nguyen H, Reitz C, Reyes D, Salerno W, Schellenberg G, Seshadri S, Sohi H, Thornton T, Valadares O, van Duijn C, Vardarajan B, Wang L, Boerwinkle E, Dupuis J, Pericak-Vance M, Mayeux R, Wijsman E. (2018) Genetic variation in genes underlying diverse dementias may explain a small proportion of cases in the Alzheimer's Disease Sequencing Project. Dementia and Geriatric Cognitive Disorders. 45(1-2):1-17. doi:10.1159/000485503, PMC5971141.

Weiner D, Wigdor EM, Ripke S, Walters RK, Kosmicki JA, Grove J, Samocha KE, Goldstein JI, Okbay A, Bybjerg-Grauholm J, Werge T, Hougaard DM, Taylor J, iPSYCH-Broad Autism Group, Psychiatric Genomics Consortium Autism Group, Skuse D, Devlin B, Anney R, Sanders SJ, Bishop D, Mortensen PB, Břrglum AD, Smith GD, Daly MJ, Robinson EB (2017) Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nature Genetics. 2017 49(7):978-985, PMC5552240. doi: 10.1038/ng.3863.

Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (2017) Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Molecular Autism. May 22;8:2, PMC5441062.

Blue E, Brown LA, Conomos MP, Kirk JL, Nato AQ Jr, Popejoy AB, Raffa J, Ranola J, Wijsman EM, Thornton T (2016) Estimating relationships between phenotypes and subjects drawn from admixed families. BMC Proceedings 10(Suppl 7):357-362, PMC5133521.

Faja S, Dawson G, Aylward E, Wijsman E, Webb SJ. (2016). Early event-related potentials to emotional faces differ for adults with autism spectrum disorder and by serotonin transporter genotype. Clinical Neurophysiology 1227(6):2436-2447. PMC5279301.

Truong D, Shriberg LD, Smith SD, Chapman KL, Scheer-Cohen AR, DeMille MMC, Adams A, Nato Jr AQ, Wijsman EM, Eicher JD, Gruen JR (2016) Multipoint genome-wide linkage scan for nonword repetition further supports chromosome 13q as a locus for verbal trait disorders in a multigenerational family. Human Genetics 135(12):1329-1341, PMC5065602.

Peter B, Wijsman EM, Nato Jr. AQ, University of Washington Center for Mendelian Genomic, Matsushita MM, Chapman KL, Stanaway IB, Wolff J, Oda K, Gabo V, Raskind WH (2016) Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. PLOS ONE e0153864. doi:10.1371/journal.pone.015386, PMC4847873.

Wijsman EM (2016) Family-based approaches: design, imputation, analysis, and beyond. BMC Genetics 17(Suppl 2):9, PMC4895701.

Nato AQ J, Chapman NH, Sohi HK, Nguyen HD, Brkanac Z, Wijsman EM (2015) PBAP: A pipeline for file processing and quality control of pedigree data with dense genetic markers. Bioinformatics 31(23):3790-3798, PMC4668752.

Chapman N, Nato AQ Jr, Bernier R, Ankenman K, Sohi H, Munson J, Patowary A, Archer M, Blue E, Webb SJ, Coon H, Raskind WH, Brkanac Z, Wijsman EM (2015) Whole exome sequencing in extended families with autism spectrum disorder implicates four candidate genes. Human Genetics 134:1055-1068, PMC4578871.

Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium Psychiatric genome-wide association study analyses implicate neurona, immune and histone pathways. Nature Neuroscience 18(2):199-209, PMC4378867.

Blue E, Sun L, Tintle NL, Wijsman EM (2014) On the value of Mendelian laws of segregation in families: data quality contro, imputation and beyond. Genetic Epidemiology 38(S1):S21-S28, PMC4135526.

Kim S, Saad M, Tsuang DW, Wijsman EM (2014) Visualization of haplotype sharing patterns in pedigree samples. Human Heredity 78:1-8, PMC4112026.

Thornton TA, Conomos MP, Sverdlov S, Blue EM, Cheung C, Glazner CG, Lewis SM, and Wijsman E. (2014) Estimating and Adjusting for Ancestry Admixture in Statistical Methods for Relatedness Inference, Heritability Estimation, and Association Testing. BMC Proceedings 8(Suppl 1):S5, PMC4143704.

Blue E, Cheung CYK, Glazner CG, Conomos MP, Lewis SM, Sverdlov S, Thornton T, Wijsman EM (2014) Identity-by-descent graphs offer a flexible framework for imputation and both linkage and association analyses. BMC Proceedings 8(Suppl 1):S19, PMC4143703.

Rubenstein K, Raskind WH, Berninger VW, Matsushita MM, Wijsman EM (2014) Genome scan for cognitive trait loci of dyslexia: rapid naming and rapid switching of letter, numbers, and colors. American Journal of Medical Genetics - Neuropsychiatric Genetics 165:345-356, PMC4053475.

Cheung CY, Thompson EA, Wijsman EM (2014) Detection of Mendelian Consistent genotyping errors in pedigrees. Genetic Epidemiology 38(4):291-299, PMC4081466.

Pinto D, Delaby E, Merico D, Barbosa M, Merikangas A, Klei L, Thiruvahindrapuram B, Xu X, Ziman R, Wang Z, Vorstman JA, Thompson A, Regan R, Pilorge M, Pellecchia G, Pagnamenta AT, Oliveira B, Marshall CR, Magalhaes TR, Lowe JK, Howe JL, Griswold AJ, Gilbert J, Duketis E, Dombroski B, De Jonge MV, Cuccaro M, Crawford EL, Correia CT, Conroy J, Conceiç IC, Chiocchetti AG, Casey J, Cai G, Cabrol C, Bolshakova N, Bacchelli E, Anney R, Gallinger S, Cotterchio M, Casey G, Zwaigenbaum L, Wittemeyer K, Wing K, Wallace S, van Engeland H, Tryfon A, Thomson S, Soorya L, Rogé, Roberts W, Poustka F, Mouga S, Minshew N, McInnes LA, McGrew SG, Lord C, Leboyer M, Le Couteur AS, Kolevzon A, Jiméz Gonzáz P, Jacob S, Holt R, Guter S, Green J, Green A, Gillberg C, Fernandez BA, Duque F , Delorme R, Dawson G, Chaste P, Café, Brennan S, Bourgeron T, Bolton PF, Bö S, Bernier R, Baird G, Bailey AJ, Anagnostou E, Almeida J, Wijsman EM, Vieland VJ, Vicente AM, Schellenberg GD, Pericak-Vance M, Paterson AD, Parr JR, Oliveira G, Nurnberger JI, Monaco AP, Maestrini E, Klauck SM, Hakonarson H, Haines JL, Geschwind DH, Freitag CM, Folstein SE, Ennis S, Coon H, Battaglia A, Szatmari P, Sutcliffe JS, Hallmayer J, Gill M, Cook EH, Buxbaum JD, Devlin B, Gallagher L, Betancur C, Scherer SW. (2014) Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. American Journal of Human Genetics 94(5):677-694, PMC4067558.

Cheung CY, Blue EM, Wijsman EM (2014) A statistical framework to guide sequencing choices in pedigrees. American Journal of Human Genetics 94:257-267, PMC3928665.

Saad M, Wijsman EM (2014) Power of Family-Based Association Designs To Detect Rare Variants in Large Pedigrees Using Imputed Genotypes. Genetic Epidemiology 38:1-9, PMC3959172.

Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone S, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne E, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger C, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman P, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green E, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath A, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk W, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Lĺngström N, Lathrop M, Lawrence J, Lawson W, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane S, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough J, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon W, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp C, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades R, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson A, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga J, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders A, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner W, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith E, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier E, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov A, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland V, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker T, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zöllner S; International Inflammatory Bowel Disease Genetics Consortium (IIBDGC, Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan P, Smoller JW, Kendler KS, Wray NR (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9):984-994, PMC3800159.

Gamsiz E, Viscidi EW, Frederick AM, Nagpal S, Sanders SJ, Murtha MT, Schmidt E, Simons Simplex Collection Genetics Consortium, Triche EW, Geschwind D, State MW, Istrail S, Cook EH Jr, Devlin B, Morrow EM. (2013) Intellectual disability is associated with increased runs of homozygosity in simplex autism. American Journal of Human Genetics. 93(1):103-109, PMC3710760.

Marchani E, Chapman NH, Cheung CYK, Ankenman K, Stanaway IB, Coon HH, Nickerson D, Bernier R, Brkanac Z, Wijsman EM (2013) Identification of rare variants from exome sequence in a large pedigree with autism. Human Heredity 74:153-164, PMC3722055.

Cheung CY, Thompson EA, Wijsman EM (2013) GIGI: An approach to effective imputation of dense genotypes on large pedigrees. American Journal of Human Genetics 92:504-516, PMC3617386.

Zhao W, Marchani EE, Cheung CYK, Steinbart EJ, Schellenberg GD, Bird TD, Wijsman EM (2013) Genome scan in familial late-onset Alzheimer's disease: a locus on chromosome 6 contributes to age at onset. American Journal of Medical Genetics - Neuropsychiatric Genetics 162(2):201-212, PMC3654841.

Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bölte S, Bolton P, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, Corsello C, Crawford E, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez B, Folstein SE, Fombonne E, Gilbert J, Gillberg C, Glessner JT, Green A, Green J, Guter SJ, Heron EA, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Jacob S, Kenny G, Kim C, Kolevzon A, Kustanovich V, Lajonchere CM, Lamb JA, Law-Smith M, Leboyer M, Le Couteur A, Leventhal BL, Liu XQ, Lombard F, Lord C, Lotspeich L, Lund S, Magalhaes TR, Mantoulan C, McDougle CJ, Melhem NM, Merikangas A, Minshew NJ, Mirza G, Munson J, Noakes C, Nygren G, Papanikolaou K, Pagnamenta AT, Parrini B, Paton T, Pickles A, Posey DJ, Poustka F, Ragoussis J, Regan R, Roberts W, Roeder K, Roge B, Rutter ML, Schlitt S, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Sykes N, Tancredi R, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent J, Volkmar F, Vorstman JA, Wallace S, Wing K, Wittemeyer K, Wood S, Zurawiecki D, Zwaigenbaum L, Bailey AJ, Battaglia A, Cantor RM, Coon H, Cuccaro ML, Dawson G, Ennis S, Freitag CM, Geschwind DH, Haines JL, Klauck SM, McMahon WM, Maestrini E, Miller J, Monaco AP, Nelson SF, Nurnberger JI Jr, Oliveira G, Parr JR, Pericak-Vance M, Piven J, Schellenberg GD, Scherer SW, Vicente AM, Wassink TH, Wijsman E, Betancur C, Buxbaum JD, Cook EH, Gallagher L, Gill M, Hallmayer J, Paterson A, Sutcliffe JS, Szatmari P, Vieland VJ, Hakonarson H, Devlin B. (2012) Individual common variants exert weak effects on risk for Autism Spectrum Disorders. Human Molecular Genetics 21:4781-4792, PMC3471395.

Wijsman EM (2012) The role of large pedigrees in an era of high-throughput sequencing. Human Genetics 131:1555-1563, PMC3638020.

Kim S, Millard SP, Yu CE, Leong L, Radant A, Dobie D, Tsuang DW, Wijsman EM (2012) Inheritance model introduces differential bias in CNV calls between parents and offspring. Genetic Epidemiology 36:488-498, PMC3678551.

Casey J, Magalhaes T, Conroy JM, Regan R, Shah N, Anney R, Shields DC, Abrahams BS, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolton P, Bourgeron T, Brennan S, Cali P, Correia C, Corsello C, Coutanche M, Dawson G, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein S, Foley S, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Green J, Guter SJ, Hakonarson H, Holt R, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Lamb JA, Leboyer M, Le Couteur A, Leventhal BL, Lord C, Lund SC, Maestrini E, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Miller J, Minopoli F, Mirza GK, Munson J, Nelson SF, Nygren G, Oliveira G, Pagnamenta A, Papanikolaou K, Parr JR, Parrini B, Pickles A, Pinto D, Piven J, Posey DJ, Poustka F, Poustka F, Ragoussis J, Roge B, Rutter ML, Sequeira AF, Soorya L, Sousa I, Sykes N, Stoppioni V, Tancredi R, Tauber M, Thompson AP, Thomson S, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Vorstman JA, Wallace S, Wang K, Wassink TH, White K, Wing K, Wittemeyer K, Yaspan BL, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Geschwind DH, Haines JL, Hallmayer J, Monaco AP, Nurnberger JI Jr, Pericak-Vance M, Schellenberg GD, Scherer SW, Sutcliffe JS, Szatmari P, Vieland VJ, Wijsman E, Green A, Gill M, Gallagher L, Vicente A, Ennis S (2012) A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Human Genetics 131:565-579, PMC3303079.

Chen Y-E, Matsushita M, Girirajan S, Lisowski M, Sun E, Sul Y, Bernier R, Estes A, Dawson G, Minshew N, Schellenberg GD, Eichler EE, Rieder MJ, Nickerson D, Tsuang DT, Tsuang MT, Wijsman EM, Raskind WH, Brkanac Z (2012) Evidence for involvement of GNB1L in autism (2012) American Journal of Medical Genetics - Neuropsychiatric Genetics 159B(1):61-67, PMC3270696.

Marchani E, Wijsman EM (2011) Estimation and visualization of identity-by-descent within pedigrees simplifies interpretation of complex trait analysis. Human Heredity 72(4):289-297, PMC3267995.

Rosenthal E, Ronald J, Rothstein J, Rajagopalan R, Ranchalis J, Wolfbauer G, Albers J, Brunzell JD, Motulsky AG, Reider MJ, Nickerson DA, Wijsman EM, Jarvik GP (2011) Linkage and association of phospholipid transfer protein activity to LASS4. Journal of Lipid Research, 52:1837-1846, PMC3173000.

Choi Y, Marchani EE, Bird TD, Steinbart EJ, Blacker D, Wijsman EM (2011) Genome scan of age-at-onset in the NIMH Alzheimer disease sample uncovers multiple loc, along with evidence of both genetic and sample heterogeneity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetic, 156(7):785-798, PMC3168696.

Anney R, Kenny EM, O'Dushlaine C, Yaspan BL, Parkhomenka E; The Autism Genome Project, Buxbaum J, Sutcliffe J, Gill M, Gallagher L; The AGP Members, Bailey AJ, Fernandez BA, Szatmari P, Scherer SW, Patterson A, Marshall CR, Pinto D, Vincent JB, Fombonne E, Betancur C, Delorme R, Leboyer M, Bourgeron T, Mantoulan C, Roge B, Tauber M, Freitag C, Poustka F, Duketis E, Klauck SM, Poustka A, Papanikolaou K, Tsiantis J, Gallagher L, Gill M, Anney R, Bolshakova N, Brennan S, Hughes G, McGrath J, Merikangas A, Ennis S, Green A, Casey JP, Conroy JM, Regan R, Shah N, Maestrini E, Bacchelli E, Minopoli F, Stoppioni V, Battaglia A, Igliozzi R, Parrini B, Tancredi R, Oliveira G, Almeida J, Duque F, Vicente A, Correia C, Magalhaes TR, Gillberg C, Nygren G, Jonge MD, Van Engeland H, Vorstman JA, Wittemeyer K, Baird G, Bolton PF, Rutter M, Green J, Lamb JA, Pickles A, Parr JR, Couteur AL, Berney T, McConachie H, Wallace S, Coutanche M, Foley S, White K, Monaco AP, Holt R, Farrar P, Pagnamenta AT, Mirza G, Ragoussis J, Sousa I, Sykes N, Wing K, Hallmayer J, Cantor RM, Nelson SF, Geschwind D, Abrahams BS, Volkmar F, Pericak-Vance MA, Cuccaro ML, Gilbert J, Cook EH, Guter S, Jacob S, Nurnberger Jr JI, McDougle CJ, Posey DJ, Lord C, Corsello C, Hus V, Buxbaum J, Kolevzon A, Soorya L, Parkhomenko E, Leventhal BL, Dawson G, Vieland VJ, Hakonarson H, Glessner JT, Kim C, Wang K, Schellenberg GD, Devlin B, Klei L, Minshew N, Sutcliffe J, Haines JL, Lund SC, Thomson S, Yaspan BL, Coon H, Miller J, McMahon WM, Munson J, Estes A, Wijsman EM. (2011) Gene ontology enrichment analysis in two independent famiy-based samples highlights biologically plausible processes for autism spectrum disorders. European Journal of Human Genetic, 19:1082-1089, PMC3190264.

Liu X, Georgiades S, Duku E, Thompson A, Devlin B, Cook EH, Wijsman EM, Paterson AD, Szatmari P (2011) Identification of genetic loci underlying the phenotypic constructs of autism spectrum disorders. Journal of the American Academy of Child & Adolescent Psychiatry 50:687-696, PMC3593812.

Vieland V, Hallmayer J, Huang Y, Pagnamenta A, Pinto D, Khan H, Monaco AP, Paterson A, Scherer SW, Sutcliffe JS, Szatmari P, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes T, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader G, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, B olton P, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Filippi T, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green A, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe J, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal B, Lionel AC, Liu X-Q, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon W, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting CP, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, SAGE Consortium, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stein O, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson A, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Webber C, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Buxbaum JD, Cantor R, Cook EH, Coon H, Cuccaro ML, Devlin B, Ennis S, Gallagher L, Geschwind D, Gill M, Haines JL, Miller J, Nurnberger Jr. JI, Pericak-Vance MA, Schellenberg G, Vicente AM, Wijsman EM, Betancur C (2011) Novel method for combined linkage and genomewide association analysis finds evidence of distinct genetic architecture for two subtypes of autism. Journal of Neurodevelopmental Disorders 3:113-123, PMC3105232.

Peter B, Raskind WH, Matsushita M, Lisowski M, Vu T, Berninger VW, Wijsman EM, Brkanac Z. Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample. (2011) Journal of Neurodevelopmental Disorders 3:39-49, PMC3163991.

Wijsman E, Pankratz ND, Choi Y, Rothstein JH, Faber KM, Cheng R, Lee JH, Bird TD, Bennett D, Diaz-Arrastia R, Goate AM, Farlow M, Ghetti B, Sweet RA, Foroud TM, Mayeux R, for The NIA-LOAD/NCRAD Family Study Group (2011) Genome Wide Association of Familial Late Onset Alzheimer's Disease Replicates BIN1 and CLU, and Nominates CUGBP2 in Interaction With APOE. PLoS Genetics 7(2):e100130, PMC3040659. link to paper

Rubenstein K, Matsushita M, Berninger VW, Raskind WH, Wijsman EM (2011) Genome scan for spelling deficits: effects of verbal IQ on models of transmission and trait gene localization. Behavior Genetics 41:31-42, PMC3030654.

Noor A, Whibley A, Marshall CR, Gianakopoulos PJ, Piton A, Carson AR, Orlic-Milacic M, Lionel A, Sato D, Pinto D, Drmic I, Noakes C, Senman L, Zhang X, Mo R, Gautheir J, Crosbie J, Pagnamenta AT, Munson J, Estes AM, Fiebig A, Franke A, Schreiber S, Stewart AFR, Robers R, McPherson R, Cuter SJ, Cook JR EH, Dawson G, Schellenberg GD, Battaglia A, Maestrini E, Autism Genome Project Consortium, Jeng L, Hutchison T, Rajcan-Separovic E, Chudley AE, Lewis SME, Liu X, Holden J, Fernandez B, Zwaigenbaum L, Bryson SE, Roberts W, Szatmari P, Gallagher L, Stratton MR, Geca J, Brady AF, Schwartz CE, Schachar RJ, Monaco AP, Rouleau GA, Hui C-C, Raymond FL, Scherer SW, Vincent JB (2010) Disruption at the PTCHD1 locus on Xp22.11 in autism spectrum disorder and intellectual disability. Science in Translational Medicine 2(49):49ra68. doi:10.1126/scitranslmed.3001267. PMC2987731.

Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta A, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, Chu SH, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck S, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon W, Melhem NM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Piven J, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink T, Wing K, Wittemeyer K, Wood S, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Gallagher L, Geschwind DH, Gill M, Haines JL, Miller J, Monaco AP, Nurnberger JI Jr, Paterson AD, Pericak-Vance MA, Schellenberg G, Scherer SW, Sutcliffe JS, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Devlin B, Ennis S, Hallmayer (2010) A genomewide scan for common alleles affecting risk for autism. Human Molecular Genetics 19:4072-408, PMC2948401.

Hoofnagle A, Wu M, Albina K. Gosmanova AK, Becker JO, Wijsman EM, Brunzell JD, Kahn S, Knopp RH, Lyons TJ, Heinecke JW (2010) Low clusterin levels in high density lipoprotein associate with insulin resistanc, obesity, and dyslipoproteinemia. Arteriosclerosis, Thrombosis, and Vascular Biology 30:2528-2534, PMC2988100.

Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson A, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner J, Goldberg J, Green A, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel A, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall C, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Migita O, Minshew N, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting CP, Posey D, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Sequeira A, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stein O, Sykes N, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson AP, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Webber C, Weksberg R, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Devlin B, Ennis S, Gallagher L, Geschwind DH, Gill M, Haines JL, Hallmayer J, Miller J, Monaco AP, Nurnberger JI J, Paterson AD, Pericak-Vance MA, Schellenberg GD, Szatmari P, Vicente AM, Vieland V, Wijsman EM, Scherer SW, Sutcliffe JS, Betancur C. (2010) Functional impact of global rare copy number variation in autism spectrum disorder. Nature 466:368-37, PMC3021798.

Marchani E, Bird TD, Steinbart EJ, Rosenthal E, Yu CE, Schellenberg GD, Wijsman EM (2010) Evidence for three loci modifying age-at-onset of Alzheimer's disease in early-onset PSEN2 families. American Journal of Medical Genetics Part B 153B:1031-104, PMC3022037.

Wijsman E, Rothstein JH, Igo RP Jr, Brunzell JD, Motulsky AG, Jarvik GP (2010) Linkage and association analyses identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families. Human Genetics 127(6):705-71, PMC2877194.

Yu C, Marchani E, Nikisch G, Muller U, Nolte D, Hertel A, Wijsman E, Bird TD (2010) The N141I Mutation in Presenilin-2: Implications for the quintessential case of Alzheimer disease. Archives of Neurology 67(5):631-63, PMC3016011.

Rosenthal E, Wijsman EM. Joint linkage and segregation analysis under multiallelic trait inheritance: Simplifying interpretations for complex traits. (2010) Genetic Epidemiology 34:344-35, PMC2914272.

Jarvik G, Rajagopalan R, Rosenthal EA, Wolfbauer G, McKinstry L, Vaze A, Brunzell J, Motulsky A, Nickerson DA, Heagerty PJ, Wijsman EM, Albers JJ. Genetic and non-genetic sources of variation in phospholipid transfer protein (PLTP) activity. (2010) Journal of Lipid Research 51:983-99, PMC2853466.

Becker L, Gharib SA, Wijsman EM, Vaisar T, Oram JF, Heinecke JW. (2010) A macrophage sterol-responsive network linked to atherogenesis. Cell Metabolism 11:125-13, PMC2893224.

Choi Y, Wijsman EM, Weir BS (2009) Case-control association testing in the presence of unknown relationships. Genetic Epidemiology 35:668-67, PMC2790016.

Marchani E, Callegaro A, Daw EW, Wijsman EM (2009) Combining information from linkage and association methods. Genetic Epidemiology 33(S1):S81-S8, PMC2910520.

Weiss L, Arking DE, The Gene Discovery Project of Johns Hopkins and the Autism Consortium (2009) A genome-wide linkage and association scan reveals novel loci for autism. Nature 461:802-80, PMC2772655.

Sieh W, Choi Y, Chapman NH, Craig U-K, Steinbart EJ, Rothstein JH, Oyanagi K, Garruto R, Bird TD, Galasko DR, Schellenberg GD, Wijsman EM (2009) Identification of novel susceptibility loci for Guam neurodegenerative disease: Challenges of genome scans in genetic isolates. Human Molecular Genetics 18:3725-3738, PMC2742398.

Ng MY, Levinson DF, Faraone SV, Suarez BK, DeLisi LE, Arinami T, Riley B, Paumio T, Pulver A, Irmansyah I, Holmans PA, Escamilla M, Wildenauer DB, Williams NM, Laurent C, Mowry B, Brzustowicz L, Mziade M, Sklar P, Garver DL, Abecasis G, Lerer B, Fallin MD, Gurling HM, Gejman PV, Lindholm E, Moises H, Byerley W, Wijsman EM, Forabosco P, Tsuang MT, Hwu H-G, Okazaki Y, Kendler KS, Wormley B, Fanous A, Walsh D, O'Neill A, Peltonen L, Nestadt G, Lasseter V, Liang KY, Papadimitriou G, Dikeos D, Schwab SG, Owen MJ, O'Donovan MC, Norton N, Hare E, Raventos H, Nicolini H, Albus M, Maier W, Nimgaonkar VL, Terenius L, Mallet J, Jay M, Godard S, Nertney D, Alexander M, Crowe RR, Silverman JM, Bassett AS, Roy M-A, Merétte C, Pato C, Louw Roos J, Yohn Y, Amann-Zalcenstein D, Kalsi G, McQuillin A, Curtis D, Brynjolfson J, Sigmundsson T, Petursson H, Sanders AR, Duan J, Jazin E, Myles-Worsley M, Karayiorgou M, Lewis CM (2009) Meta-analysis of 32 genomewide linkage studies of schizophrenia. Molecular Psychiatry 14:774-78, PMC2715392.

Brkanac Z, Chapman NH, Igo RP Jr, Matsushita MM, Nielsen K, Berninger V, Wijsman EM, Raskind WH (2008) Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple loci. Behavior Genetics 38:462-7, PMC2853749.

Crawford D, Nord AS, Badzioch MD, Ranchalis J, McKinstry LA, Ahearn M, Bertucci C, Shephard C, Wong M, Rieder MJ, Schellenberg GD, Nickerson DA, Heagerty PJ, Wijsman EM, Jarvik GP (2008) VLDLR common genetic variation and interaction with APOE is associated with carotid artery disease. Journal of Lipid Research 49:588-596.

Berninger V, Nielsen KH, Abbott RD, Wijsman EM, Raskind WH (2008) Gender differences in severity of writing and reading disabilities. Journal of School Psychology 46:151-172.

Igo RP Jr, Wijsman EM (2008) Empirical significance values for linkage analysis: trait simulation using posterior model distributions from MCMC oligogenic segregation analysis. Genetic Epidemiology 32:119-131.

Berninger V, Nielsen KH, Abbott RD, Carlisle J, Nagy W, Wijsman E, Raskind W (2008) Writing problems in developmental dyslexia: Under-recognized and under-treated. Journal of School Psychology 46:1-21.

Wijsman E, Sung YJ, Buil A (2007) Summary of GAW15: Group 9 linkage analysis of the CEPH expression data. Genetic Epidemiology 31(Suppl 1):S75-S85.

Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter D, Thomas G, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni Jr. JF, Freimer NB, Gerhard DS, Gunter C, Guttmacher A, Guyer MS, Harris EL, Hirschhorn JJ, Hoh J, Hoover R, Kong C, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn D, Collins FS. What Constitutes Replication of a Genotype-Phenotype Association? Summary of an NCI-NHGRI Working Group (2007) Nature 447:655-660.

Brkanac Z, Chapman NH, Matsushita MM, Chun L, Nielsen K, Cochrane E, Berninger V, Wijsman EM, Raskind WH (2007) Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia. American Journal of Medical Genetic, Neuropsychiatric Genetics 144B:556-560.

Yu C-E, Seltman H, Peskind ER, Galloway N, Zhou PX, Rosenthal E, Wijsman EM, Tsuang D, Devlin B, Schellenberg GD (2007) Comprehensive Analysis of APOE and Selected Proximate Markers for Late-onset Alzheimer Disease: Pattern of Linkage Disequilibrium and Disease/Marker Association. Genomics 89:655-665.

The Autism Genome Project (AGP) Consortium (2007) Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics 39:319-32, PMID: 17322880.

Sundar P, Yu C-E, Sieh W, Steinbart E, Garruto RM, Oyanagi K, Craig U-K, Bird TD, Wijsman EM, Galasko DR, Schellenberg GD (2007) Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia. Human Molecular Genetics 16:295-306.

Sung Y, Wijsman EM (2007) Accounting for epistasis in linkage analysis of general pedigrees. Human Heredity 63:144-152.

Sieh W, Yu C-E, Bird TD, Schellenberg GD, Wijsman EM (2007) Accounting for linkage disequilibrium among markers in linkage analysis: impact of haplotype frequency estimation and molecular haplotypes for a gene in a candidate region for Alzheimer's disease. Human Heredity 63:26-34.

Sung Y, Thompson EA, Wijsman EM (2007) MCMC-based linkage analysis for complex traits on general pedigrees: multipoint analysis with a two-locus model and a polygenic component. Genetic Epidemiology 31:103-114.

Wijsman E, Rothstein JH, Thompson EA (2006) Multipoint linkage analysis with many multiallelic or dense diallelic markers: MCMC provides practical approaches for genome scans on general pedigrees. American Journal of Human Genetics 79:846-858. Simulated data set is available here.

Berninger V, Abbott RD, Thomson J, Wagner R, Swanson HL, Wijsman EM, Raskind W (2006) Modeling phonological core deficits within a working memory architecture in children and adults with developmental dyslexia. Scientific Studies of Reading 10:165-198.

Igo RP Jr, Chapman NH, Wijsman EM (2006) Segregation analysis of a complex quantitative trait: approaches for identifying influential data points. Human Heredity 61:80-86.

Igo RP J, Chapman NH, Berninger VW, Matsushita M, Brkanac Z, Rothstein JH, Holzman T, Nielsen K, Raskind WH, Wijsman EM (2006) Genomewide scan for real-word reading subphenotypes of dyslexia: Novel chromosome 13 locus and genetic complexity. American Journal of Medical Genetic, Neuropsychiatric Genetics 141B:15-27.

Sieh W, Basu S, Fu AQ, Rothstein JH, Scheet PA, Stewart WCL, Sung YJ, Thompson E, Wijsman EM (2005) Comparison of marker types and map assumptions using MCMC-based linkage analysis of COGA data. BMC Genetics [Suppl] 6:11.

Wilcox M, Pugh EW, Zhang H, Zhong X, Levinson DF, Kennedy GC, Wijsman EM (2005) Comparison of Single-Nucleotide Polymorphisms and Microsatellite Markers for Linkage Analysis in the COGA and Simulated Datasets for Genetic Analysis Workshop 14: Presentation Groups 1, 2 and 3. Genetic Epidemiology 29 (Suppl 1):S7-S28.

Gagnon F, Jarvik GP, Badzioch MD, Motulsky AG, Brunzell JD, Wijsman EM (2005) Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia. Human Genetics 117:494-505.

Raskind W, Igo R Jr, Chapman NH, Berninger VW, Matsushita M, Brkanac Z, Holzman T, Brown M, Thomson J, Wijsman EM (2005) A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency. Molecular Psychiatry 10:699-711.

George A, Wijsman EM, Thompson EA (2005) MCMC multilocus lod scores: application of a new approach. Human Heredity 59:98-108.

Wijsman E, Daw EW, Yu X, Steinbart EJ, Nochlin D, Bird TD, Schellenberg GD (2005) APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation. American Journal of Medical Genetics (Neuropsychiatric Genetics) 132B:14-20.

Sung Y, Dawson G, Munson J, Estes A, Schellenberg GD, Wijsman EM (2005) Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment. American Journal of Human Genetics 76:68-81.

Chapman N, Igo RP, Thomson JB, Matsushita M, Brkanac Z, Holzman T, Berninger VW, Wijsman E, Raskind WH (2004) Linkage analysis of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15q. American Journal of Medical Genetic, Neuropsychiatric Genetics 131B:67-75.

Badzioch M, Igo RP Jr, Gagnon F, Brunzell JD, Krauss RM, Motulsky AG, Wijsman E, Jarvik GP (2004) LDL particle size loci in familial combined hyperlipidemia: Evidence for multiple loci from a genome scan. Arteriosclerosis, Thrombosis and Vascular Biology 24:1942-1950.

Wijsman E, Daw EW, Yu C-E, Payami H, Steinbart EJ, Nochlin D, Conlon EM, Bird T, Schellenberg GD (2004) Evidence for a novel late-onset Alzheimer's disease locus on chromosome 19p13.2. American Journal of Human Genetics 75:398-409.

Wijsman E, Robinson NM, Ainsworth KH, Rosenthal EA, Holzman T, Raskind WH (2004). Familial aggregation patterns in mathematical ability. Behavior Genetics 34:51-62.

Wijsman EM (2003) Summary of Group 8: Development and extension of linkage methods. Genetic Epidemiology 25(Suppl 1):S64-S71.

Gagnon F, Jarvik GP, Motulsky AG, Deeb SS, Brunzell JD, Wijsman EM (2003) Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment. Human Genetics 113:522-533.

George A, Basu S, Li N, Rothstein JH, Sieberts SK, Stewart W, Wijsman EM, Thompson EA (2003) Approaches to mapping genetically correlated complex traits. Bio Med Central Genetics [Suppl 1] 4:S71.

Chapman N, Raskind WH, Thomson JB, Berninger V, Wijsman EM (2003) Segregation analysis of phenotypic components of learning disabilities. II. Phonological decoding. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 121B:60-70.

Wijsman E, Rosenthal EA, Hall D, Blundell ML, Sobin C, Heath SC, Williams R, Brownstein M, Gogos JA, Karayiorgou M (2003) Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: evidence for linkage to chromosome 2q. Molecular Psychiatry 8:695-705.

Matise T, Sachidanandam R, Kakol J, Clark AG, Kruglyak L, Wijsman E, Buyske S, Chui B, Cohen P, de Toma C, Ehm M, Glanowski S, He C, Heil J, McMullen I, Pericak-Vance M, Silbergleit A, Stein L, Wagner M, Wilson AF, Winick JD, Winn-Deen E, Yamashiro CT, Cann HM, Lai E, Holden AL. (2003) A 3.9 cM-Resolution Human SNP Linkage Map and Screening Set. The American Journal of Human Genetics 73:271-284.

Conlon E, Goode EL, Gibbs M, Stanford JL, Badzioch M, Janer M, Kolb S, Hood L, Ostrander EA, Jarvik GP, Wijsman EM (2003) Oligogenic segregation analysis of hereditary prostate cancer pedigrees: evidence for multiple loci affecting age-at-onset. International Journal of Cancer 105:630-635.

Daw E, Wijsman EM, Thompson EA (2003) A Score for Bayesian Genome Screening. Genetic Epidemiology 24:181-190.

Hall D, Wijsman EM, Roos JL, Gogos JA, Karayiorgou M (2002) Extended intermarker linkage disequilibrium in the Afrikaners. Genome Research 12:956-961.

Yu C-E, Dawson G, Munson J, D'Souza I, Osterling J, Estes A, Leutenegger A-L, Flodman P, Smith M, Raskind WH, Spence MA, McMahon W, Wijsman EM, Schellenberg GD (2002) Presence of large deletions in kindreds with autism. The American Journal of Human Genetics, 71:100-115.

Hsu H, Wijsman EM, Berninger VW, Thomson JB, Raskind WH (2002) Familial aggregation of dyslexia phenotypes II: Paired correlated measures. American Journal of Medical Genetics (Neuropsychiatric Genetics, 114:471-478.

Goddard KA, Wijsman EM (2002) Characteristics of genetic markers and maps for cost-effective genome screens using diallelic markers. Genetic Epidemiology 22:205-220.

Liu H, Heath SC, Sobin C, Roos LJ, Galke BL, Blundell ML, Lenane M, Robertson B, Wijsman EM, Rapoport JL, Gogos JA, Karayiorgou M (2002) Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proceedings of the National Academy of Science, USA 99:3717-3722.

Sieberts S, Thompson EA, Wijsman EM (2002) Relationship inference from trios of individuals in the presence of typing error. American Journal of Human Genetic, 70:170-180.

Chapman NH and Wijsman EM (2001) Introduction: Linkage analyses in the Hutterites. Genetic Epidemiology 21(Suppl 1):S222-S223. in Analysis of complex genetic traits: Applications to asthma and simulated data. Wijsman E, Almasy L, Amos CI, Borecki I, Falk C, King TM, Martinez MM, Meyers D, Neuman R, Olson JM, Rich S, Spence MA, Thomas D, Vieland VJ, Witte JS, MacCluer JW, eds., (2001). Genetic Epidemiology, Volume 21(Suppl 1), pgs. S1-S853.

Chapman N, Leutenegger A-L, Badzioch MD, Bogdan M, Conlon EM, Daw EW, Gagnon F, Li N, Maia JM, Wijsman EM, Thompson EA (2001) The Importance of Connections: Joining components of the Hutterite pedigree. Genetic Epidemiology 21(Suppl 1):S230-S235. in Analysis of complex genetic traits: Applications to asthma and simulated data. Wijsman E, Almasy L, Amos CI, Borecki I, Falk C, King TM, Martinez MM, Meyers D, Neuman R, Olson JM, Rich S, Spence MA, Thomas D, Vieland VJ, Witte JS, MacCluer JW, eds., (2001). Genetic Epidemiolog, Volume 21(Suppl 1), pgs. S1-S853.

Wijsman E, Nur N (2001) On estimating the proportion of variance attributable to a measured locus. Human Heredity 51:145-149.

Hadley E, Albers SM, Bailey-Wilson J, Baron J, Cawthon R, Christian JC, Corder EH, Franceschi F, Kestenbaum B, Kruglyak L, Lauderdale DS, Lubitz J, Martin GM, McClearn G, McGue M, Miles T, Mineau G, Ouellette G, Pedersen NL, Preston SH, Page W, Province M, Schachter F, Schork NJ, Vaupel JW, Vijg J, Wallace R, Wang E, Wijsman EM. Genetic Epidemiologic Studies on Age-Specified Traits. The American Journal of Epidemiology 11:1003-1008

Daw E, Thompson EA, Wijsman EM (2000) Bias in multipoint linkage analysis arising from map misspecification. Genetic Epidemiology 19:366-380.

Wijsman EM, Peterson D, Leutenegger A-L, Thomson JB, Goddard KAB, Hsu L, Berninger VB, Raskind WH (2000) Segregation analysis of phenotypic components of learning disabilitie, I. Nonword memory and digit span. The American Journal of Human Genetics 67:631-646.

Wijsman EM (2000) Monte Carlo Markov chain methods and model selection in genetic epidemiology. Computational statistics and data analysis. 32:349-360.

Saavedra C, Chapman N, Wijsman EM, Horowitz ST, Rosen DR (2000) Linkage of hereditary distal myopathy with desmin accumulation to 2q. Human Heredity 50:166-170.

Daw E, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM (2000) The number of trait loci in late-onset Alzheimer's disease. The American Journal of Human Genetics 66:196-204.

Daw E, Kumm J, Snow GL, Thompson EA, Wijsman EM (1999) MCMC methods for genome screening. In: Goldin L, Amos CI, Chase GA, Goldstein AM, Jarvik GP, Martinez MM, Suarez B, Weeks DE, Wijsman EM, MacCluer JW. Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases. Genetic Epidemiology 17(suppl 1):S133-S138.

Sjoberg G, Saavedra-Matiz CA, Rosen DR, Wijsman EM, Borg K, Horowitz SH, Sejersen T (1999) A missense mutation in the desmin rod domain is associated with autosomal dominant distal myopath, and exerts a dominant negative effect on filament formation. Human Moleular Genetics 8:2191-2198.

Daw E, Heath SC, Wijsman EM (1999) Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer pedigrees. American Journal of Human Genetics 64:839-851.

Austin M, Stephens K, Walden CE, Wijsman E (1999) Linkage analysis of candidate genes and the smal, dense low-density lipoprotein phenotype. Atherosclerosis. 142:79-87

Hokanson J, Brunzell JD, Jarvik GP, Wijsman EM, Austin MA (1999) Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. American Journal of Human Genetics 64:608-618.

Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD (1998) Tau is a candidate gene for chromosome 17 frontotemporal dementia. Annals of Neurology 43:815-825.

Snow G, Wijsman EM (1998) Pedigree analysis package (PAP) vs. MORGAN: Model selection and hypothesis testing on a large pedigree. Genetic Epidemiology 15:355-369.

Li H, Thompson EA, Wijsman EM (1998) Semiparametric estimation of major gene effects for age of onset. Genetic Epidemiology 15:279-298.

Raskind W, Conrad EU, Matsushita M, Wijsman EM, Wells DE, Chapman N, Sandell LJ, Wagner JH, Houck J (1998) Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostoses. Human Mutation 11:231-239.

Wijsman E, Brunzell JB, Jarvik GP, Austin MA, Motulsky AG, Deeb SS (1998) Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex. Arteriosclerosis, Thrombosis, and Vascular Biology. 18:215-226.

Berninger VW, Raskind W, McCutchen D, Richards T, Cunningham A, Nolen S, Wijsman E, Dager S, Corina D, Abbott R (1997) Educational and biological links to learning disabilities. Perspectives vol 2, no. 4.

Yu C-E, Oshima J, Wijsman EM, Nakura J, Miki T, Piussan C, Matthews S, Fu Y-H, Mulligan J, Martin GM, Schellenberg GD, and members of the International Werner's Syndrome Collaborative Group (1997) Mutations in the consensus helicase domains of the Werner's syndrome gene. American Journal of Human Genetics 60:330-341.

Graham J, Chapman NH, Goddard KAB, Goode EL, Wijsman EM, Jarvik GP (1997) Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees. Genetic Epidemiology 14:999-1004.

Heath S, Snow GL, Thompson EA, Tseng C, Wijsman EM (1997) MCMC segregation and linkage analysis. Genetic Epidemiology 14:1011-1016.

Wijsman EM (1997) Monte Carlo Methods and model selection in genetic analysis. Animal Biotechnology 8:129-144.

Wijsman E, Amos CI (1997) Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions. Genetic Epidemiology 14:719-736.

Edland S, Wijsman EM, Schoder-Ehri G, Leverenz J (1997) Little evidence of reduced survival to adulthood of apoE e4 homozygotes in Down's syndrome. NeuroReport 8:3463-3465.

Olshen A, Wijsman EM (1996) Pedigree Analysis Package vs. MIXD: fitting the mixed model on a large pedigree. Genetic Epidemiology 13:91-106.

Jarvik G, Larson EB, Goddard K, Kukull WA, Schellenberg GD, Wijsman EM (1996) Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. American Journal of Human Genetics 58:191-200.

Payami H, Zareparsi S, Montee KR, Sexton GJ, Kaye JA, Bird TD, Yu C-E, Wijsman E, Heston LL, Litt M, Schellenberg GD (1996) Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease (AD): a possible clue to the higher incidence of Alzheimer Disease in women. American Journal of Human Genetics 58:803-811.

Edland S, Silverman JM, Peskind ER, Tsuang D, Wijsman E, Morris JC (1996) Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance. Neurology 47:254-256.

Goddard KA, Yu C-E, Oshima J, Miki T, Nakura J, Piussan C, Martin GM, Schellenberg G, Wijsman EM, and members of the International Werner's Syndrome Collaborative Group (1996) Towards localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers. American Journal of Human Genetics 58:1286-1302.

Yu C-E, Oshima J, Fu Y-H, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD (1996) Positional cloning of the Werner's syndrome gene. Science 272:258-262.

Nakura J, Miki T, Le L, Mitsuda N, Zhao Y, Kihara K, Yu C-E, Oshima J, Fukuchi K, Wijsman EM, Schellenberg GD, Martin GM, Murano S, Hashimoto K, Fujiwara Y, Ogihara T (1996) Narrowing the position of the Werner syndrome locus by homozygosity analysis - extension of homozygosity. Genomics 36:130-141.

Stephens K, Zlotogorski A, Smith L, Ehrlich P, Wijsman E, Livingston R, Sybert VP (1995) Epidermolysis bullosa simplex: a keratin 5 mutation is a fully dominant allele in epidermal cytoskeleton function. American Journal of Human Genetics 56:577-585.

Goddard KA, Jarvik GP, Graham J, McNeney B, Hsu L, Siegmund K, Grosser S, Olson J, Wijsman EM (1995) Analysis of quantitative risk factors for a common oligogenic disease. Genetic Epidemiology 12:759-764.

Querfurth HW, Wijsman E, St. George-Hyslop PH, Selkoe D (1995) bAPP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Molecular Brain Research 28:319-337.

Koller W, Glatt SL, Hubble JP, Paolo A, Tröster AI, Handler MS, Horvat R, Martin C, Schmidt K, Karst A, Wijsman EM, Yu C-E, Schellenberg GD (1995) Apolipoprotein E genotypes in Parkinson's disease with and without dementia. Annals of Neurology 37:242-245.

Brunzell J, Austin MA, Deeb SS, Hokanson JE, Jarvik GP, Nevin DN, Wijsman EM, Zambon A, Motulsky AG (1995) Familial combined hyperlipidemia and genetic risk for atherosclerosis. Atherosclerosis X:624-627.

Levy-Lahad L, Wijsman EM, Nemens E, Anderson L, Goddard KAB, Weber, J, Bird TD, Schellenberg GD (1995) A familial Alzheimer's disease locus on chromosome 1. Science 269:970-973.

Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu C-E, Jondro PD, Schmidt SD, Wang K, Crowley AC, Fu Y-H, Guenette SY, Galas D, Nemens E, Wijsman EM, Bird TD, Schellenberg GD, Tanzi RE (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-977.

Levy-Lahad E, Lahad A, Wijsman EM, Bird TD, Schellenberg GD (1995) ApoE genotypes and age of onset in early-onset familial Alzheimer's disease. Annals of Neurology 38:678-680.

Palmer S, Dale DC, Livingston RJ, Wijsman EM, Stephens K (1994) Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5. Human Genetic, 93:195-197.

Lin S, Thompson EA, Wijsman EM (1994) Finding non-communicating sets for Markov chain Monte Carlo estimations on pedigrees. American Journal of Human Genetics 54:695-704.

Yu C-E, Payami H, Olson JM, Boehnke M, Wijsman EM, Orr HT, Kukull WA, Goddard KA, Nemens E, White JA, Alonso ME, Taylor TD, Ball MJ, Kaye J, Morris J, Chui H, Sadovnick AD, Martin GM, Larson EB, Heston LL, Bird TD, Schellenberg GD (1994) The Apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer's disease. American Journal of Human Genetics 54:631-642.

Palmer S, Scherer SW, Kukolich M, Wijsman EM, Tsui L-C, Stephens K, Evans JP (1994) Evidence for locus heterogeneity in human autosomal dominant split hand/split foot malformation. American Journal of Human Genetics 55:21-26.

Yu C-E, Oshima J, Goddard KAB, Miki T, Nakura J, Ogihara T, Poot M, Hoehn H, Fraccaro M, Piussan C, Martin GM, Schellenberg GD, Wijsman EM (1994) Linkage disequilibrium and haplotype studies of chromosome 8p 11.1-21.1 markers and Werner's sydrome. American Journal of Human Genetics 55:356-364.

Olson J, Wijsman EM (1994) Design and sample size considerations in the detection of linkage disequilibrium with a disease locus. American Journal of Human Genetics 55:574-580.

Lin S, Thompson E, Wijsman E (1994) An algorithm for Monte Carlo estimation of genotype probabilities on complex pedigrees. Annals of Human Genetics 58:343-357.

Nakura J, Wijsman EM, Miki T, Kamino K, Yu C-E, Oshima J, Fukuchi K, Weber J, Piussan C, Malaragno MI, Epstein CJ, Scappaticci S, Fraccaro M, Matsumura T, Murano S, Yoshida S, Fujiwara Y, Saida T, Ogihara T, Martin G, Schellenberg GD. (1994) Homozygosity mapping of the Werner's syndrome locus (WRN). Genomics 23:600-608.

Jarvik G, Brunzell JD, Austin MA, Krauss RM, Motulsky AG, Wijsman EM (1994) Genetic predictors of familial combined hyperlipidemia in four large pedigrees: influence of apolipoprotein B level major locus predicted genotype and low density lipoprotein subclass phenotype. Arteriosclerosis and Thrombosis 14:1687-1694.

Olson J, Wijsman EM (1993) Linkage between quantitative trait and marker loci: methods using all relative pairs. Genetic Epidemiology 10:87-102.

Lin S, Thompson E, Wijsman E (1993) Achieving irreducibility of the Markov chain Monte Carlo method applied to pedigree data. IMA Journal of Mathematics Applied in Medicine and Biology 10:1-17.

Wijsman E, Bird TD, Martin GM, Schellenberg GD (1993) The Seattle Alzheimer's disease data set. Genetic Epidemiology 10:365-369.

Wijsman EM (1993) Genetic analysis of Alzheimer's disease: summary of GAW8. Genetic Epidemiology 10:349-360.

Thompson E, Lin S, Olshen AB, Wijsman EM (1993) Monte Carlo segregation and linkage analysis of a large hypercholesterolemia pedigree. Genetic Epidemiology 10:677-682.

Stephens K, Sybert VP, Wijsman EM, Ehrlich P, Spencer A (1993) A keratin 14 mutational hot spot for epidermolysis bullosa simple, Dowling-Meara: implications for diagnosis. Journal of Investigative Dermatology 101:240-243.

Bonnycastle LL, Yu C-E, EM Wijsman EM, Orr HT, Patterson D, Clancy K, Goddard KAB, Alonso ME, Nemens E, White JA, Heston LL, Martin GM, Bird T, Schellenberg GD (1993) The c-fos gene and early-onset familial Alzheimer's disease. Neuroscience Letters 163:33-36.

Schellenberg G, Payami H, Wijsman EM, Orr HT, Goddard KAB, Anderson L, Nemens E, White JA, Alonso ME, Ball MJ, Kaye J, Morris JC, Chui H, Sadovnick A, Heston LL, Martin GM, Bird TD (1993) Chromosome 14 and late-onset familial Alzheimer disease. American Journal of Human Genetics 53:619-628.

Cook A, Raskind W, Blanton SH, Pauli R, Gregg RG, Francomano C, Puffenberger E, Conrad EU, Schmale G, Schellenberg G, Wijsman E, Hect J, Wells DE, Wagner JH (1993) Genetic heterogeneity in families with hereditary multiple exostoses. American Journal of Human Genetics 53:71-79.

Nakura J, Miki T, Nagano K, Kihara K, Ye L, Kamino K, Fujiwara Y, Yoshida , Murano S, Fukuchi K-I, Wijsman EM, Martin GM, Schellenberg GD, Ogihara T (1993) Close linkage of the gene for Werner's syndrome to ANK1 and D8S87 on the short arm of chromosome 8. Gerontology 39 (suppl):11-15.

Schellenberg G, Boehnke M, Wijsman EM, Moore DK, Martin GM, Bird TD (1992) Genetic association and linkage analysis of the Apo CII locus and familial Alzheimer's disease. Annals of Neurology 31:223-227.

Austin M, Horowitz H, Wijsman E, Krauss RM, Brunzell J (1992) Bimodality of Plasma Apolipoprotein B levels in Familial Combined Hyperlipidemia. Atherosclerosis 92:67-77.

Deeb S, Failor RA, Brown BG, Brunzell JD, Albers JJ, Motulsky AG, Wijsman E (1992) Association of Apolipoprotein B gene variants with Plasma apoB and LDL Cholesterol Levels. Human Genetics 88:463-470.

Kamino K, Orr HT, Payami H, Wijsman EM, Anderson L, O'dahl S, Nemens E, White JA, Sadovnick AD, Ball MJ, Warren A, Sharma V, Kukull W, Larson E, Heston LL, Martin GM, Bird TD, Schellenberg GD (1992) Linkage and mutational analysis of familial Alzheimer's disease kindreds for the APP gene region. American Journal of Human Genetics 51:998-1014.

Wijsman EM. (1992) Principles of linkage analysis applied to genetic mapping of familial Alzheimer's disease. Current Science 63:487-491.

Schellenberg G, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, White J, Bonnycastle L, Weber JL, Alonso ME, Potter H, Heston LL, Martin GM (1992) Genetic linkage evidence for a familial Alzheimer disease locus on chromosome 14. Science 258:668-671.

Schellenberg G, Pericak-Vance MA, Wijsman EM, Moore DK, Gaskell Jr. P, Yamaoka LA, Bebout JL, Anderson L, Welsh KA, Clark CM, Martin GM, Roses A, Bird TD (1991) Linkage analysis of familial Alzheimer's disease using chromosome 21 markers. The American Journal of Human Genetics 48:563-583.

Wijsman, EM. (1991) Recurrence risk of a new dominant mutation in children of unaffected parents. The American Journal of Human Genetics 48:654-661.

Schellenberg G, Anderson L, O'dahl S, Wijsman EM, Sadovnick AD, Ball M, Larson EB, Kukull WA, Martin GM, Roses AD, Bird TD (1991) APP717, APP693, and PRIP gene mutations are rare in Alzheimer's disease. The American Journal of Human Genetics 49:511-517.

Austin M, Wijsman E, Guo S, Krauss RM, Brunzell JD, Deeb S (1991) Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia. Genetic Epidemiology 8:287-297.

Schellenberg G, Bird TD, Wijsman EM, Moore DK, Martin GM (1989) The genetics of Alzheimer's Disease. Biomedicine and Pharmacotherapy 43:463-468.

Schellenberg G, Bird TD, Wijsman EM, Moore DK, Boehnke M, Bryant EM, Lampe T, Nochlin D, Sumi M, Deeb SS, Beyreuther K, Martin GM(1988) Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 241:1507-1510.

Darby J, Willems PJ, Nakashima P, Johnsen J, Ferrell RE, Wijsman EM, Gerhard JK, Dracopoli NC, Housman D, Henke J, Fowler ML, Shows TB, O'Brien J, Cavalli-Sforza LL (1988) Restriction analysis of the structural alpha-L- fucosidase gene and its linkage to fucosidosis. The American Journal of Human Genetics 43:749-755.

Bowcock A, Hebert JM, Christiano AM, Wijsman E, Cavalli-Sforza LL, Boyd CD (1987) The pro alpha 1 (IV) collagen gene is linked to the D13S3 locus at the distal end of human chromosome 13q. Cytogenetics and Cell Genetics 45:234-236.

Feder J, Yen L, Wijsman E, Wang L, Wilkins L, Schroder J, Spurr N, Cann H, Blumenberg M, Cavalli-Sforza LL (1985) A systematic approach for detecting high frequency restriction fragment length polymorphisms using large genomic probes. American Journal of Human Genetics 37:635-649.

Wijsman E, Zei G, Moroni A, Cavalli-Sforza LL (1984) Surnames in Sardinia II. Computation of migration matrices from surname distributions in different periods. Annals of Human Genetics 48:65-78.

Wijsman EM (1984) Techniques for estimating genetic admixture and applications to the problem of the origin of the Icelanders and the Ashkenazi Jews. Human Genetics 67:441-448.

Wijsman E, Cavalli-Sforza LL (1984) Migration and genetic population structure. Annual Review of Ecology and Systematic, 15:279-301.

Wijsman EM (1984) Optimizing selection of restriction enzymes in the search for DNA variants. Nucleic Acids Research 12:9209-9226.

Wijsman EM (2002) Joint linkage and segregation analysis using Markov chain Monte Carlo methods. In Methods in Molecular Biology: vol. 195: Quantitative trait loci: methods and protocols. (N Camp and A Co, eds) Humana Press, Inc. pp. 139-161.

Bird T, Lampe TH, Wijsman EM, Schellenberg GD (1998) Familial Alzheimer's disease: Genetic studies in neurobiology of primary dementia. Association for research in nervous and mental diseases (MF Folstei, ed), American Psychiatric Pres, Inc., Washington DC, pp 27-41.

Wijsman, EM (1998) Mendel's Laws. in Encyclopedia of Biostatistics, vol 5, Human Genetics (P Armitage and T Colton, Eds), John Wiley & Son, Sussex, pp 2568-2569.

Wijsman, EM (1998) Penetrance. in Encyclopedia of Biostatistics, vol 5, Human Genetics (P Armitage and T Colton, Eds), John Wiley & Sons, Susse, pp 3321-3323.

Bird T, Lampe TH, Wijsman EM, Schellenberg GD (1998) Familial Alzheimer's disease: Genetic studies. in Neurobiology of primary dementia (MF Folstei, Ed, Association for Research in Nervous and Mental Diseases, American Psychiatric Pres, Inc., Washington, DC. pp. 27-41

Wijsman EM (1997) Association vs. linkage analysis in mental disorders. in Handbook of Psychiatric genetic, K Blum and E Noble, eds., CRC Press, Inc, Boca Raton, pp. 7-23.

Bird TD, EM Nemens, D Nochlin, SM Sumi, EM Wijsman, and GD Schellenberg (1992) Familial Alzheimer's disease in Germans from Russia: A model of genetic heterogeneity in Alzheimer's disease. in Heterogeneity of Alzheimer's disease (F Bolle, F Forette, Z Khachaturian, M Poncet, and Y Christen, eds, Springer Verlag, New York, pp. 118-129.

Wijsman EM (1990) Linkage analysis of alcoholism: problems and solutions. in Banbury Report 33: Genetics and Biology of Alcoholism. Cold Spring Harbor Laboratory Pres, New York, pp. 317-326.

Schellenberg, GD, EM Wijsman, TD Bird, DK Moore, and GM Martin (1990) Linkage analysis of familial Alzheimer's disease: Genetic heterogeneity and the search for the gene. International Congress Series. Molecular Biology and Genetics of Alzheimer's Disease: Proceedings of the International Symposium on Dementia. eds. T Miyatak, DJ Selkoe, and Y Ihara., pp. 245-254.

Bird, TD, TH Lampe, EJ Nemens, SM Sumi, D Nochlin, GD Schellenberg, EM Wijsman (1988) Characteristics of familial Alzheimer's disease in nine kindreds of Volga German ancestry. in Alzheimer's disease and related disorders. Alan R. Lis, Inc., New York, pp 229-234.

Wijsman, EM (1986) Estimation of genetic admixture in the Pygmies. in African Pygmies (LL Cavalli-Sforza, ed), Academic Press, Inc., New York, pp. 347-358.

Cordell HJ, de Andrade M, Babron M-C, Bartlett CW, Beyene J, Bickebör H, Culverhouse R, Cupples A, Daw EW, Dupuis J, Falk CT, Ghosh S, Goddard KAB, Goode EL, Hauser ER, Martin LJ, Martinez M, North KE, Saccone NL, Schmidt S, Tapper W, Thomas D, Tritchler D, Vieland VJ, Wijsman EM, Wilcox MA, Witte JS, Yang Q, Ziegler A, Almasy L, MacCluer JW (eds) Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci. BMC Proceedings, Volume 1 (Suppl 1), S1-S168 (2007).

Wijsman E, Almasy L, Amos CI, Borecki I, Falk C, King TM, Martinez MM, Meyers D, Neuman R, Olson JM, Rich S, Spence MA, Thomas D, Vieland VJ, Witte JS, MacCluer JW, eds., (2001). Genetic Analysis Workshop 12. Analysis of complex genetic traits: Applications to asthma and simulated data. Genetic Epidemiology, Volume 21(Suppl 1), pgs. S1-S853.

Goldin L, Amos CI, Chase GA, goldstein AM, Jarvik GP, Martinez MM, Suarez BK, Weeks D, Wijsman EM, MacCluer JW (1999). Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases. Genetic Epidemiolog, vol 1, supplement 1.

Wijsman EM (1998) Penetrance - what is it? Proceedings of the 1998 American Statistical Association meeting, Epidemiology section, pp 16-23.

Wijsman E, Lin S (1995) Monte Carlo methods in genetic epidemiology: opportunities and problems. Proceedings of the 1995 American Statistical Association meeting, Epidemiology sectio, pp 38-47.

Evans J, Palmer S, Scherer SW, Kukolich M, Wijsman EM, Tsui L-C, Stephens K (1995) Letter to the Editor regarding "Heterogeneity of the autosomal dominant split hand/split foot malformation". American Journal Of Human Genetics 56:342-343.

Wijsman E, Lin S. (1995) Monte Carlo methods in genetic epidemiology: opportunities and problems. Proceedings of the 1995 American Statistical Association meeting, Epidemiology section, pp 38-47.

Payami H, Montee K, Kaye J, Bird T, Yu C-E, Wijsman EM, Schellenberg G (1994) Alzheimer diseas, Apolipoprotein E4 dosage, and gender. JAMA 271:1316-1317.

Jarvik GP and Wijsman EM (1994) Letter to the editor. Nature Genetics 8:115.

Schellenberg GD, GM Martin, EM Wijsman, J Nakura, T Miki, and T Ogihara (1992) Homozygosity mapping and Werner's syndrome. Lancet 339:1002.

Thompson, EA and EM Wijsman (1990) The Gibbs sampler on extended pedigrees: Monte Carlo methods for the genetic analysis of complex traits. Technical Report no. 19, Department of Statistics, University of Washington.

Wijsman EM (1985) Reply to Gilbert. Evolution 39:941-943.

Wijsman EM (1981) The effect of ether on mating behavior in D. simulans y w. Drosophila Information Service. 56:158.