Ellen M. Wijsman

Manuscripts in refereed journals


In Press
Saad M, Wijsman EM (2014) Combining family- and population-based imputation data for association analysis of rare and common variants in large pedigrees. Genetic Epidemiology (in press).


2014
Blue EM, Sun L, Tintle NL, Wijsman EM (2014) On the value of Mendelian laws of segregation in families: data quality control, imputation and beyond. Genetic Epidemiology 38(S1):S21-S28, PMC4135526.

Kim S, Saad M, Tsuang DW, Wijsman EM (2014) Visualization of haplotype sharing patterns in pedigree samples. Human Heredity 78:1-8, PMC4112026.

Thornton T, Conomos MP, Sverdlov S, Blue EM, Cheung C, Glazner CG, Lewis SM, and Wijsman E. (2014) Estimating and Adjusting for Ancestry Admixture in Statistical Methods for Relatedness Inference, Heritability Estimation, and Association Testing. BMC Proceedings 8(Suppl 1):S5.

Blue EE, Cheung CYK, Glazner CG, Conomos MP, Lewis SM, Sverdlov S, Thornton T, Wijsman EM (2014) Identity-by-descent graphs offer a flexible framework for imputation and both linkage and association analyses. BMC Proceedings 8(Suppl 1):S19.

Rubenstein K, Raskind WH, Berninger VW, Matsushita MM, Wijsman EM (2014) Genome scan for cognitive trait loci of dyslexia: rapid naming and rapid switching of letters, numbers, and colors. American Journal of Medical Genetics - Neuropsychiatric Genetics 165:345-356, PMC4053475.

Cheung CYK, Thompson EA, Wijsman EM (2014) Detection of Mendelian Consistent genotyping errors in pedigrees. Genetic Epidemiology 38(4):291-299, PMC4081466.

Pinto D, Delaby E, Merico D, Barbosa M, Merikangas A, Klei L, Thiruvahindrapuram B, Xu X, Ziman R, Wang Z, Vorstman JA, Thompson A, Regan R, Pilorge M, Pellecchia G, Pagnamenta AT, Oliveira B, Marshall CR, Magalhaes TR, Lowe JK, Howe JL, Griswold AJ, Gilbert J, Duketis E, Dombroski BA, De Jonge MV, Cuccaro M, Crawford EL, Correia CT, Conroy J, Conceiç IC, Chiocchetti AG, Casey JP, Cai G, Cabrol C, Bolshakova N, Bacchelli E, Anney R, Gallinger S, Cotterchio M, Casey G, Zwaigenbaum L, Wittemeyer K, Wing K, Wallace S, van Engeland H, Tryfon A, Thomson S, Soorya L, Rogé, Roberts W, Poustka F, Mouga S, Minshew N, McInnes LA, McGrew SG, Lord C, Leboyer M, Le Couteur AS, Kolevzon A, Jiméz Gonzáz P, Jacob S, Holt R, Guter S, Green J, Green A, Gillberg C, Fernandez BA, Duque F, Delorme R, Dawson G, Chaste P, Café, Brennan S, Bourgeron T, Bolton PF, Bö S, Bernier R, Baird G, Bailey AJ, Anagnostou E, Almeida J, Wijsman EM, Vieland VJ, Vicente AM, Schellenberg GD, Pericak-Vance M, Paterson AD, Parr JR, Oliveira G, Nurnberger JI, Monaco AP, Maestrini E, Klauck SM, Hakonarson H, Haines JL, Geschwind DH, Freitag CM, Folstein SE, Ennis S, Coon H, Battaglia A, Szatmari P, Sutcliffe JS, Hallmayer J, Gill M, Cook EH, Buxbaum JD, Devlin B, Gallagher L, Betancur C, Scherer SW. (2014) Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. American Journal of Human Genetics 94(5):677-694, PMC4067558.

Cheung CYK, Blue EM, Wijsman EM (2014) A statistical framework to guide sequencing choices in pedigrees. American Journal of Human Genetics 94:257-267, PMC3928665.

Saad M, Wijsman EM (2014) Power of Family-Based Association Designs To Detect Rare Variants in Large Pedigrees Using Imputed Genotypes. Genetic Epidemiology 38:1-9, PMC3959172.


2013
Rosenthal EA, Ranchalis J, Crosslin DR, Burt A, Brunzell JD, Motulsky AG, Nickerson DA, NHLBI GO Exome Sequencing Project, Wijsman EM, Jarvik GP (2013) Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia. American Journal of Human Genetics 93:1035-1045, PMC3852929.

Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Långström N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zöllner S; International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9):984-994, PMC3800159.

Gamsiz ED, Viscidi EW, Frederick AM, Nagpal S, Sanders SJ, Murtha MT, Schmidt M, Simons Simplex Collection Genetics Consortium, Triche EW, Geschwind DH, State MW, Istrail S, Cook EH Jr, Devlin B, Morrow EM. (2013) Intellectual disability is associated with increased runs of homozygosity in simplex autism. American Journal of Human Genetics. 93(1):103-109, PMC3710760.

Marchani EE, Chapman NH, Cheung CYK, Ankenman K, Stanaway IB, Coon HH, Nickerson D, Bernier R, Brkanac Z, Wijsman EM (2013) Identification of rare variants from exome sequence in a large pedigree with autism. Human Heredity 74:153-164, PMC3722055.

Cheung CYK, Thompson EA, Wijsman EM (2013) GIGI: An approach to effective imputation of dense genotypes on large pedigrees. American Journal of Human Genetics 92:504-516, PMC3617386.

Zhao W, Marchani EE, Cheung CYK, Steinbart EJ, Schellenberg GD, Bird TD, Wijsman EM (2013) Genome scan in familial late-onset Alzheimer's disease: a locus on chromosome 6 contributes to age at onset. American Journal of Medical Genetics - Neuropsychiatric Genetics 162(2):201-212, PMC3654841.


2012
Suzuki M, Becker L, Pritchard DK, Gharib SA, Wijsman E, Bammler TK, Beyer RP, Vaisar T, Oram JF, Heinecke JW (2012) Cholesterol accumulation regulates the expression of macrophage proteins implicated in proteolysis and complement activation. Arteriosclerosis, Thrombosis, and Vascular Biology 32:2910-2918, PMC3501207.

Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, Corsello C, Crawford EL, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Gilbert J, Gillberg C, Glessner JT, Green A, Green J, Guter SJ, Heron EA, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Jacob S, Kenny GP, Kim C, Kolevzon A, Kustanovich V, Lajonchere CM, Lamb JA, Law-Smith M, Leboyer M, Le Couteur A, Leventhal BL, Liu XQ, Lombard F, Lord C, Lotspeich L, Lund SC, Magalhaes TR, Mantoulan C, McDougle CJ, Melhem NM, Merikangas A, Minshew NJ, Mirza GK, Munson J, Noakes C, Nygren G, Papanikolaou K, Pagnamenta AT, Parrini B, Paton T, Pickles A, Posey DJ, Poustka F, Ragoussis J, Regan R, Roberts W, Roeder K, Roge B, Rutter ML, Schlitt S, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Sykes N, Tancredi R, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Vorstman JA, Wallace S, Wing K, Wittemeyer K, Wood S, Zurawiecki D, Zwaigenbaum L, Bailey AJ, Battaglia A, Cantor RM, Coon H, Cuccaro ML, Dawson G, Ennis S, Freitag CM, Geschwind DH, Haines JL, Klauck SM, McMahon WM, Maestrini E, Miller J, Monaco AP, Nelson SF, Nurnberger JI Jr, Oliveira G, Parr JR, Pericak-Vance MA, Piven J, Schellenberg GD, Scherer SW, Vicente AM, Wassink TH, Wijsman EM, Betancur C, Buxbaum JD, Cook EH, Gallagher L, Gill M, Hallmayer J, Paterson AD, Sutcliffe JS, Szatmari P, Vieland VJ, Hakonarson H, Devlin B. (2012) Individual common variants exert weak effects on risk for Autism Spectrum Disorders. Human Molecular Genetics 21:4781-4792, PMC3471395.

Wijsman EM (2012) The role of large pedigrees in an era of high-throughput sequencing. Human Genetics 131:1555-1563, PMC3638020.

Kim S, Millard SP, Yu CE, Leong L, Radant A, Dobie D, Tsuang DW, Wijsman EM (2012) Inheritance model introduces differential bias in CNV calls between parents and offspring. Genetic Epidemiology 36:488-498, PMC3678551.

Casey JP, Magalhaes T, Conroy JM, Regan R, Shah N, Anney R, Shields DC, Abrahams BS, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolton PF, Bourgeron T, Brennan S, Cali P, Correia C, Corsello C, Coutanche M, Dawson G, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Foley S, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Green J, Guter SJ, Hakonarson H, Holt R, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Lamb JA, Leboyer M, Le Couteur A, Leventhal BL, Lord C, Lund SC, Maestrini E, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Miller J, Minopoli F, Mirza GK, Munson J, Nelson SF, Nygren G, Oliveira G, Pagnamenta AT, Papanikolaou K, Parr JR, Parrini B, Pickles A, Pinto D, Piven J, Posey DJ, Poustka A, Poustka F, Ragoussis J, Roge B, Rutter ML, Sequeira AF, Soorya L, Sousa I, Sykes N, Stoppioni V, Tancredi R, Tauber M, Thompson AP, Thomson S, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Vorstman JA, Wallace S, Wang K, Wassink TH, White K, Wing K, Wittemeyer K, Yaspan BL, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Geschwind DH, Haines JL, Hallmayer J, Monaco AP, Nurnberger JI Jr, Pericak-Vance MA, Schellenberg GD, Scherer SW, Sutcliffe JS, Szatmari P, Vieland VJ, Wijsman EM, Green A, Gill M, Gallagher L, Vicente A, Ennis S (2012) A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Human Genetics 131:565-579, PMC3303079.

Chen Y-Z, Matsushita M, Girirajan S, Lisowski M, Sun E, Sul Y, Bernier R, Estes A, Dawson G, Minshew N, Schellenberg GD, Eichler EE, Rieder MJ, Nickerson DA, Tsuang DT, Tsuang MT, Wijsman EM, Raskind WH, Brkanac Z (2012) Evidence for involvement of GNB1L in autism (2012) American Journal of Medical Genetics - Neuropsychiatric Genetics 159B(1):61-71, PMC3270696.


2011

Marchani EE, Wijsman EM (2011) Estimation and visualization of identity-by-descent within pedigrees simplifies interpretation of complex trait analysis. Human Heredity 72(4):289-297, PMC3267995.

Rosenthal EA, Ronald J, Rothstein J, Rajagopalan R, Ranchalis J, Wolfbauer G, Albers JJ, Brunzell JD, Motulsky AG, Reider MJ, Nickerson DA, Wijsman EM, Jarvik GP (2011) Linkage and association of phospholipid transfer protein activity to LASS4. Journal of Lipid Research, 52:1837-1846, PMC3173000.

Choi Y, Marchani EE, Bird TD, Steinbart EJ, Blacker D, Wijsman EM (2011) Genome scan of age-at-onset in the NIMH Alzheimer disease sample uncovers multiple loci, along with evidence of both genetic and sample heterogeneity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 156(7):785-798, PMC3168696.

Anney RJ, Kenny EM, O'Dushlaine C, Yaspan BL, Parkhomenka E; The Autism Genome Project, Buxbaum JD, Sutcliffe J, Gill M, Gallagher L; The AGP Members, Bailey AJ, Fernandez BA, Szatmari P, Scherer SW, Patterson A, Marshall CR, Pinto D, Vincent JB, Fombonne E, Betancur C, Delorme R, Leboyer M, Bourgeron T, Mantoulan C, Roge B, Tauber M, Freitag CM, Poustka F, Duketis E, Klauck SM, Poustka A, Papanikolaou K, Tsiantis J, Gallagher L, Gill M, Anney R, Bolshakova N, Brennan S, Hughes G, McGrath J, Merikangas A, Ennis S, Green A, Casey JP, Conroy JM, Regan R, Shah N, Maestrini E, Bacchelli E, Minopoli F, Stoppioni V, Battaglia A, Igliozzi R, Parrini B, Tancredi R, Oliveira G, Almeida J, Duque F, Vicente A, Correia C, Magalhaes TR, Gillberg C, Nygren G, Jonge MD, Van Engeland H, Vorstman JA, Wittemeyer K, Baird G, Bolton PF, Rutter ML, Green J, Lamb JA, Pickles A, Parr JR, Couteur AL, Berney T, McConachie H, Wallace S, Coutanche M, Foley S, White K, Monaco AP, Holt R, Farrar P, Pagnamenta AT, Mirza GK, Ragoussis J, Sousa I, Sykes N, Wing K, Hallmayer J, Cantor RM, Nelson SF, Geschwind DH, Abrahams BS, Volkmar F, Pericak-Vance MA, Cuccaro ML, Gilbert J, Cook EH, Guter SJ, Jacob S, Nurnberger Jr JI, McDougle CJ, Posey DJ, Lord C, Corsello C, Hus V, Buxbaum JD, Kolevzon A, Soorya L, Parkhomenko E, Leventhal BL, Dawson G, Vieland VJ, Hakonarson H, Glessner JT, Kim C, Wang K, Schellenberg GD, Devlin B, Klei L, Minshew N, Sutcliffe JS, Haines JL, Lund SC, Thomson S, Yaspan BL, Coon H, Miller J, McMahon WM, Munson J, Estes A, Wijsman EM. (2011) Gene ontology enrichment analysis in two independent famiy-based samples highlights biologically plausible processes for autism spectrum disorders. European Journal of Human Genetics, 19:1082-1089, PMC3190264.

Liu XQ, Georgiades S, Duku E, Thompson A, Devlin B, Cook EH, Wijsman EM, Paterson AD, Szatmari P (2011) Identification of genetic loci underlying the phenotypic constructs of autism spectrum disorders. Journal of the American Academy of Child & Adolescent Psychiatry 50:687-696, PMC3593812.

Vieland VJ, Hallmayer J, Huang Y, Pagnamenta A, Pinto D, Khan H, Monaco AP, Paterson AD, Scherer SW, Sutcliffe JS, Szatmari P, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes T, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, B olton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Filippi T, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green A, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu X-Q, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting CP, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, SAGE Consortium, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stein O, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Webber C, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Devlin B, Ennis S, Gallagher L, Geschwind DH, Gill M, Haines JL, Miller J, Nurnberger Jr. JI, Pericak-Vance MA, Schellenberg GD, Vicente AM, Wijsman EM, Betancur C (2011) Novel method for combined linkage and genomewide association analysis finds evidence of distinct genetic architecture for two subtypes of autism. Journal of Neurodevelopmental Disorders 3:113-123, PMC3105232.

Peter B, Raskind WH, Matsushita M, Lisowski M, Vu T, Berninger VW, Wijsman EM, Brkanac Z. Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample. (2011) Journal of Neurodevelopmental Disorders 3:39-49, PMC3163991.

Wijsman EM, Pankratz ND, Choi Y, Rothstein JH, Faber KM, Cheng R, Lee JH, Bird TD, Bennett DA, Diaz-Arrastia R, Goate AM, Farlow M, Ghetti B, Sweet RA, Foroud TM, Mayeux R, for The NIA-LOAD/NCRAD Family Study Group (2011) Genome Wide Association of Familial Late Onset Alzheimer's Disease Replicates BIN1 and CLU, and Nominates CUGBP2 in Interaction With APOE. PLoS Genetics 7(2):e1001308, PMC3040659. link to paper

Rubenstein K, Matsushita M, Berninger VW, Raskind WH, Wijsman EM (2011) Genome scan for spelling deficits: effects of verbal IQ on models of transmission and trait gene localization. Behavior Genetics 41:31-42, PMC3030654.


2010
Chapman NH, Estes A, Munson J, Bernier R, Webb SJ, Rothstein JH, Minshew NJ, Dawson G, Schellenberg GD, Wijsman EM (2010) Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16. Human Genetics 129:59-70, PMC3082447.

Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, Chu SH, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Melhem NM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Piven J, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Wing K, Wittemeyer K, Wood S, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Gallagher L, Geschwind DH, Gill M, Haines JL, Miller J, Monaco AP, Nurnberger JI Jr, Paterson AD, Pericak-Vance MA, Schellenberg GD, Scherer SW, Sutcliffe JS, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Devlin B, Ennis S, Hallmayer (2010) A genomewide scan for common alleles affecting risk for autism. Human Molecular Genetics 19:4072-4082, PMC2948401.

Hoofnagle AN, Wu M, Albina K. Gosmanova AK, Becker JO, Wijsman EM, Brunzell JD, Kahn SE, Knopp RH, Lyons TJ, Heinecke JW (2010) Low clusterin levels in high density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia. Arteriosclerosis, Thrombosis, and Vascular Biology 30:2528-2534, PMC2988100.

Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green A, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting CP, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Sequeira AF, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stein O, Sykes N, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Webber C, Weksberg R, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Devlin B, Ennis S, Gallagher L, Geschwind DH, Gill M, Haines JL, Hallmayer J, Miller J, Monaco AP, Nurnberger JI Jr, Paterson AD, Pericak-Vance MA, Schellenberg GD, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Scherer SW, Sutcliffe JS, Betancur C. (2010) Functional impact of global rare copy number variation in autism spectrum disorder. Nature 466:368-372, PMC3021798.

Marchani EE, Bird TD, Steinbart EJ, Rosenthal E, Yu CE, Schellenberg GD, Wijsman EM (2010) Evidence for three loci modifying age-at-onset of Alzheimer's disease in early-onset PSEN2 families. American Journal of Medical Genetics Part B 153B:1031-1041, PMC3022037.

Wijsman EM, Rothstein JH, Igo RP Jr, Brunzell JD, Motulsky AG, Jarvik GP (2010) Linkage and association analyses identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families. Human Genetics 127(6):705-719, PMC2877194.

Yu CE, Marchani E, Nikisch G, Muller U, Nolte D, Hertel A, Wijsman E, Bird TD (2010) The N141I Mutation in Presenilin-2: Implications for the quintessential case of Alzheimer disease. Archives of Neurology 67(5):631-633, PMC3016011.

Rosenthal EA, Wijsman EM. Joint linkage and segregation analysis under multiallelic trait inheritance: Simplifying interpretations for complex traits. (2010) Genetic Epidemiology 34:344-353, PMC2914272.

Jarvik GP, Rajagopalan R, Rosenthal EA, Wolfbauer G, McKinstry L, Vaze A, Brunzell J, Motulsky AG, Nickerson DA, Heagerty PJ, Wijsman EM, Albers JJ. Genetic and non-genetic sources of variation in phospholipid transfer protein (PLTP) activity. (2010) Journal of Lipid Research 51:983-990, PMC2853466.

Becker L, Gharib SA, Wijsman EM, Vaisar T, Oram JF, Heinecke JW. (2010) A macrophage sterol-responsive network linked to atherogenesis. Cell Metabolism 11:125-135, PMC2893224.


2009
Marchani EE, Di Y, Choi Y, Cheung C, Su M, Boehm F, Thompson EA, Wijsman EM (2009) Contrasting IBD estimators, association studies, and linkage analysis using the Framingham data. BMC Proceedings 3(Suppl 7):S102, PMC2795873.

Choi Y, Wijsman EM, Weir BS (2009) Case-control association testing in the presence of unknown relationships. Genetic Epidemiology 35:668-678, PMC2790016.

Marchani EE, Callegaro A, Daw EW, Wijsman EM (2009) Combining information from linkage and association methods. Genetic Epidemiology 33(S1):S81-S87, PMC2910520.

Weiss LA, Arking DE, The Gene Discovery Project of Johns Hopkins and the Autism Consortium (2009) A genome-wide linkage and association scan reveals novel loci for autism. Nature 461:802-808, PMC2772655.

Sieh W, Choi Y, Chapman NH, Craig U-K, Steinbart EJ, Rothstein JH, Oyanagi K, Garruto RM, Bird TD, Galasko DR, Schellenberg GD, Wijsman EM (2009) Identification of novel susceptibility loci for Guam neurodegenerative disease: Challenges of genome scans in genetic isolates. Human Molecular Genetics 18:3725-3738, PMC2742398.

Ng MYM, Levinson DF, Faraone SV, Suarez BK, DeLisi LE, Arinami T, Riley B, Paumio T, Pulver AE, Irmansyah I, Holmans PA, Escamilla M, Wildenauer DB, Williams NM, Laurent C, Mowry BJ, Brzustowicz L, Mziade M, Sklar P, Garver DL, Abecasis G, Lerer B, Fallin MD, Gurling HMD, Gejman PV, Lindholm E, Moises H, Byerley W, Wijsman EM, Forabosco P, Tsuang MT, Hwu H-G, Okazaki Y, Kendler KS, Wormley B, Fanous A, Walsh D, O’Neill A, Peltonen L, Nestadt G, Lasseter VK, Liang KY, Papadimitriou G, Dikeos D, Schwab SG, Owen MJ, O’Donovan MC, Norton N, Hare E, Raventos H, Nicolini H, Albus M, Maier W, Nimgaonkar VL, Terenius L, Mallet J, Jay M, Godard S, Nertney D, Alexander M, Crowe RR, Silverman JM, Bassett AS, Roy M-A, Merétte C, Pato CN, Louw Roos J, Yohn Y, Amann-Zalcenstein D, Kalsi G, McQuillin A, Curtis D, Brynjolfson J, Sigmundsson T, Petursson H, Sanders AR, Duan J, Jazin E, Myles-Worsley M, Karayiorgou M, Lewis CM (2009) Meta-analysis of 32 genomewide linkage studies of schizophrenia. Molecular Psychiatry 14:774-785, PMC2715392.


2008
Liu X-Q, Paterson AD, Szatmari P, and the Autism Genome Project Consortium (2008). Genome-wide linkage analyses of quantitative and categorical autism sub-phenotypes. Biological Psychiatry 64:561-570, PMC2670970.

Brkanac Z, Chapman NH, Igo RP Jr, Matsushita MM, Nielsen K, Berninger VW, Wijsman EM, Raskind WH (2008) Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple loci. Behavior Genetics 38:462-75, PMC2853749.

Crawford DC, Nord AS, Badzioch MD, Ranchalis J, McKinstry LA, Ahearn M, Bertucci C, Shephard C, Wong M, Rieder MJ, Schellenberg GD, Nickerson DA, Heagerty PJ, Wijsman EM, Jarvik GP (2008) VLDLR common genetic variation and interaction with APOE is associated with carotid artery disease. Journal of Lipid Research 49:588-596.

Berninger VW, Nielsen KH, Abbott RD, Wijsman EM, Raskind WH (2008) Gender differences in severity of writing and reading disabilities. Journal of School Psychology 46:151-172.

Igo RP Jr, Wijsman EM (2008) Empirical significance values for linkage analysis: trait simulation using posterior model distributions from MCMC oligogenic segregation analysis. Genetic Epidemiology 32:119-131.

Berninger VW, Nielsen KH, Abbott RD, Carlisle J, Nagy W, Wijsman E, Raskind W (2008) Writing problems in developmental dyslexia: Under-recognized and under-treated. Journal of School Psychology 46:1-21.


2007
Sung YJ, Di Y, Fu AQ, Rothstein JH, Sieh W, Tong L, Thompson EA, Wijsman EM (2007) Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric lod scores, variance components lod scores, and Bayes factors. BMC Proceedings 1(Suppl 1):S93.

Wijsman EM, Sung YJ, Buil A (2007) Summary of GAW15: Group 9 linkage analysis of the CEPH expression data. Genetic Epidemiology 31(Suppl 1):S75-S85.

Chanock S, Manolio T, Boehnke M, Boerwinkle E, Hunter D, Thomas G, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni Jr. JF, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hirschhorn JJ, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM, Collins FS. What Constitutes Replication of a Genotype-Phenotype Association? Summary of an NCI-NHGRI Working Group (2007) Nature 447:655-660.

Brkanac Z, Chapman NH, Matsushita MM, Chun L, Nielsen K, Cochrane E, Berninger VW, Wijsman EM, Raskind WH (2007) Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia. American Journal of Medical Genetics, Neuropsychiatric Genetics 144B:556-560.

Yu C-E, Seltman H, Peskind ER, Galloway N, Zhou PX, Rosenthal E, Wijsman EM, Tsuang DW, Devlin B, Schellenberg GD (2007) Comprehensive Analysis of APOE and Selected Proximate Markers for Late-onset Alzheimer Disease: Pattern of Linkage Disequilibrium and Disease/Marker Association. Genomics 89:655-665.

The Autism Genome Project (AGP) Consortium (2007) Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics 39:319-328, PMID: 17322880.

Sundar PD, Yu C-E, Sieh W, Steinbart E, Garruto RM, Oyanagi K, Craig U-K, Bird TD, Wijsman E, Galasko DR, Schellenberg GD (2007) Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia. Human Molecular Genetics 16:295-306.

Sung YJ, Wijsman EM (2007) Accounting for epistasis in linkage analysis of general pedigrees. Human Heredity 63:144-152.

Sieh W, Yu C-E, Bird TD, Schellenberg GD, Wijsman EM (2007) Accounting for linkage disequilibrium among markers in linkage analysis: impact of haplotype frequency estimation and molecular haplotypes for a gene in a candidate region for Alzheimer's disease. Human Heredity 63:26-34.

Sung YJ, Thompson EA, Wijsman EM (2007) MCMC-based linkage analysis for complex traits on general pedigrees: multipoint analysis with a two-locus model and a polygenic component. Genetic Epidemiology 31:103-114.


2006
Schellenberg GD, Dawson G, Sung YJ, Estes A, Munson J, Rosenthal E, Rothstein J, Flodman P, Smith M, Coon H, Leong L, Yu C-E, Stodgell C, Rodier PM, Spence MA, Minshew N, McMahon WM, Wijsman EM (2006) Evidence for multiple loci from a genome scan of autism kindreds. Molecular Psychiatry 11:1049-1060.

Wijsman EM, Rothstein JH, Thompson EA (2006) Multipoint linkage analysis with many multiallelic or dense diallelic markers: MCMC provides practical approaches for genome scans on general pedigrees. American Journal of Human Genetics 79:846-858. Simulated data set is available here.

Berninger VW, Abbott RD, Thomson J, Wagner R, Swanson HL, Wijsman EM, Raskind W (2006) Modeling phonological core deficits within a working memory architecture in children and adults with developmental dyslexia. Scientific Studies of Reading 10:165-198.

Igo RP Jr, Chapman NH, Wijsman EM (2006) Segregation analysis of a complex quantitative trait: approaches for identifying influential data points. Human Heredity 61:80-86.

Igo RP Jr, Chapman NH, Berninger VW, Matsushita M, Brkanac Z, Rothstein JH, Holzman T, Nielsen K, Raskind WH, Wijsman EM (2006) Genomewide scan for real-word reading subphenotypes of dyslexia: Novel chromosome 13 locus and genetic complexity. American Journal of Medical Genetics, Neuropsychiatric Genetics 141B:15-27.


2005
Dawson G, Webb SJ, Wijsman E, Schellenberg G, Estes A, Munson J, Faja S (2005) Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: Implications for a model of abnormal development of social brain circuitry in autism. Development and Psychopathology 17:679-697

Sieh W, Basu S, Fu AQ, Rothstein JH, Scheet PA, Stewart WCL, Sung YJ, Thompson EA, Wijsman EM (2005) Comparison of marker types and map assumptions using MCMC-based linkage analysis of COGA data. BMC Genetics [Suppl] 6:11.

Wilcox MA, Pugh EW, Zhang H, Zhong X, Levinson DF, Kennedy GC, Wijsman EM (2005) Comparison of Single-Nucleotide Polymorphisms and Microsatellite Markers for Linkage Analysis in the COGA and Simulated Datasets for Genetic Analysis Workshop 14: Presentation Groups 1, 2 and 3. Genetic Epidemiology 29 (Suppl 1):S7-S28.

Gagnon F, Jarvik GP, Badzioch MD, Motulsky AG, Brunzell JD, Wijsman EM (2005) Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia. Human Genetics 117:494-505.

Raskind WH, Igo R Jr, Chapman NH, Berninger VW, Matsushita M, Brkanac Z, Holzman T, Brown M, Thomson J, Wijsman EM (2005) A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency. Molecular Psychiatry 10:699-711.

George AW, Wijsman EM, Thompson EA (2005) MCMC multilocus lod scores: application of a new approach. Human Heredity 59:98-108.

Wijsman EM, Daw EW, Yu X, Steinbart EJ, Nochlin D, Bird TD, Schellenberg GD (2005) APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation. American Journal of Medical Genetics (Neuropsychiatric Genetics) 132B:14-20.

Sung YJ, Dawson G, Munson J, Estes A, Schellenberg GD, Wijsman EM (2005) Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment. American Journal of Human Genetics 76:68-81.


2004
Wijsman EM, Yu D (2004) Joint oligogenic segregation and linkage analysis using Bayesian Markov chain Monte Carlo Methods. Molecular Biotechnology 28:205-226.

Chapman NH, Igo RP, Thomson JB, Matsushita M, Brkanac Z, Holzman T, Berninger VW, Wijsman EM, Raskind WH (2004) Linkage analysis of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15q. American Journal of Medical Genetics, Neuropsychiatric Genetics 131B:67-75.

Badzioch MD, Igo RP Jr, Gagnon F, Brunzell JD, Krauss RM, Motulsky AG, Wijsman EM, Jarvik GP (2004) LDL particle size loci in familial combined hyperlipidemia: Evidence for multiple loci from a genome scan. Arteriosclerosis, Thrombosis and Vascular Biology 24:1942-1950.

Wijsman EM, Daw EW, Yu C-E, Payami H, Steinbart EJ, Nochlin D, Conlon EM, Bird TD, Schellenberg GD (2004) Evidence for a novel late-onset Alzheimer's disease locus on chromosome 19p13.2. American Journal of Human Genetics 75:398-409.

Wijsman EM, Robinson NM, Ainsworth KH, Rosenthal EA, Holzman T, Raskind WH (2004). Familial aggregation patterns in mathematical ability. Behavior Genetics 34:51-62.


2003
Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D, Heffernan M, Daw JAW, Robarge J, Ott J, Kwok P-Y, Menter A, Bowcock AM (2003) A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nature Genetics 35:349-356.

Wijsman EM (2003) Summary of Group 8: Development and extension of linkage methods. Genetic Epidemiology 25(Suppl 1):S64-S71.

Gagnon, F, Jarvik GP, Motulsky AG, Deeb SS, Brunzell JD, Wijsman EM (2003) Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment. Human Genetics 113:522-533.

George AW, Basu S, Li N, Rothstein JH, Sieberts SK, Stewart W, Wijsman EM, Thompson EA (2003) Approaches to mapping genetically correlated complex traits. Bio Med Central Genetics [Suppl 1] 4:S71.

Chapman NH, Raskind WH, Thomson JB, Berninger V, Wijsman EM (2003) Segregation analysis of phenotypic components of learning disabilities. II. Phonological decoding. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 121B:60-70.

Wijsman EM, Rosenthal EA, Hall D, Blundell ML, Sobin C, Heath SC, Williams R, Brownstein MJ, Gogos JA, Karayiorgou M (2003) Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: evidence for linkage to chromosome 2q. Molecular Psychiatry 8:695-705.

Matise TC, Sachidanandam R, Kakol J, Clark AG, Kruglyak L, Wijsman E, Buyske S, Chui B, Cohen P, de Toma C, Ehm M, Glanowski S, He C, Heil J, McMullen I, Pericak-Vance MA, Silbergleit A, Stein L, Wagner M, Wilson AF, Winick JD, Winn-Deen ES, Yamashiro CT, Cann HM, Lai E, Holden AL. (2003) A 3.9 cM-Resolution Human SNP Linkage Map and Screening Set. The American Journal of Human Genetics 73:271-284.

Conlon EM, Goode EL, Gibbs M, Stanford JL, Badzioch M, Janer M, Kolb S, Hood L, Ostrander EA, Jarvik GP, Wijsman EM (2003) Oligogenic segregation analysis of hereditary prostate cancer pedigrees: evidence for multiple loci affecting age-at-onset. International Journal of Cancer 105:630-635.

Daw EW, Wijsman EM, Thompson EA (2003) A Score for Bayesian Genome Screening. Genetic Epidemiology 24:181-190.


2002
Sultana R, Yu C-E, Yu J, Munson J, Chen D, Hua W, Estes A, Cortes F, de la Barra F, Yu D, Haider ST, Trask BJ, Green ED, Raskind WH, Disteche CM, Wijsman E, Dawson G, Storm DR, Schellenberg GD, Villacres EC (2002) Identification of a Novel Gene on Chromosome 7q11.2 Interrupted by a Translocation Breakpoint in a Pair of Autistic Twins. Genomics 80:129-134.

Hall D, Wijsman EM, Roos JL, Gogos JA, Karayiorgou M (2002) Extended intermarker linkage disequilibrium in the Afrikaners. Genome Research 12:956-961.

Yu C-E, Dawson G, Munson J, D'Souza I, Osterling J, Estes A, Leutenegger A-L, Flodman P, Smith M, Raskind WH, Spence MA, McMahon W, Wijsman EM, Schellenberg GD (2002) Presence of large deletions in kindreds with autism. The American Journal of Human Genetics, 71:100-115.

Hsu L, Wijsman EM, Berninger VW, Thomson JB, Raskind WH (2002) Familial aggregation of dyslexia phenotypes II: Paired correlated measures. American Journal of Medical Genetics (Neuropsychiatric Genetics), 114:471-478.

Goddard KAB, Wijsman EM (2002) Characteristics of genetic markers and maps for cost-effective genome screens using diallelic markers. Genetic Epidemiology 22:205-220.

Liu H, Heath SC, Sobin C, Roos LJ, Galke BL, Blundell ML, Lenane M, Robertson B, Wijsman EM, Rapoport JL, Gogos JA, Karayiorgou M (2002) Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proceedings of the National Academy of Sciences, USA 99:3717-3722.

Sieberts SK, Thompson EA, Wijsman EM (2002) Relationship inference from trios of individuals in the presence of typing error. American Journal of Human Genetics, 70:170-180.


2001
Poorkaj P, Tsuang D, Wijsman E, Steinbart E, Garruto RM, Craig UK, Chapman NH, Anderson L, Bird TD, Plato CC, Perl DP, Weiderholt W, Galasko D, Schellenberg GD (2001) Tau is a candidate gene for amyotrophic lateral sclerosis-parkinsonism dementia complex of Guam. Archives of Neurology 58:1871-1878.

Chapman NH and Wijsman EM (2001) Introduction: Linkage analyses in the Hutterites. Genetic Epidemiology 21(Suppl 1):S222-S223. in Analysis of complex genetic traits: Applications to asthma and simulated data. Wijsman EM, Almasy L, Amos CI, Borecki I, Falk CT, King TM, Martinez MM, Meyers D, Neuman R, Olson JM, Rich S, Spence MA, Thomas DC, Vieland VJ, Witte JS, MacCluer JW, eds., (2001). Genetic Epidemiology, Volume 21(Suppl 1), pgs. S1-S853.

Chapman NH, Leutenegger A-L, Badzioch MD, Bogdan M, Conlon EM, Daw EW, Gagnon F, Li N, Maia JM, Wijsman EM, Thompson EA (2001) The Importance of Connections: Joining components of the Hutterite pedigree. Genetic Epidemiology 21(Suppl 1):S230-S235. in Analysis of complex genetic traits: Applications to asthma and simulated data. Wijsman EM, Almasy L, Amos CI, Borecki I, Falk CT, King TM, Martinez MM, Meyers D, Neuman R, Olson JM, Rich S, Spence MA, Thomas DC, Vieland VJ, Witte JS, MacCluer JW, eds., (2001). Genetic Epidemiology, Volume 21(Suppl 1), pgs. S1-S853.

Wijsman EM, Nur N (2001) On estimating the proportion of variance attributable to a measured locus. Human Heredity 51:145-149.


2000
Raskind, WH, Hsu L, Berninger VW, Thomson JB, Wijsman EM (2000) Familial aggregation of dyslexia phenotypes. Behavior Genetics 30:385-396.

Hadley EC, Albers SM, Bailey-Wilson J, Baron J, Cawthon R, Christian JC, Corder EH, Franceschi C, Kestenbaum B, Kruglyak L, Lauderdale DS, Lubitz J, Martin GM, McClearn GE, McGue M, Miles T, Mineau G, Ouellette G, Pedersen NL, Preston SH, Page WF, Province M, Schachter F, Schork NJ, Vaupel JW, Vijg J, Wallace R, Wang E, Wijsman EM. Genetic Epidemiologic Studies on Age-Specified Traits. The American Journal of Epidemiology 11:1003-1008

Daw EW, Thompson EA, Wijsman EM (2000) Bias in multipoint linkage analysis arising from map misspecification. Genetic Epidemiology 19:366-380.

Wijsman, EM, Peterson D, Leutenegger A-L, Thomson JB, Goddard KAB, Hsu L, Berninger VB, Raskind WH (2000) Segregation analysis of phenotypic components of learning disabilities, I. Nonword memory and digit span. The American Journal of Human Genetics 67:631-646.

Wijsman EM (2000) Monte Carlo Markov chain methods and model selection in genetic epidemiology. Computational statistics and data analysis. 32:349-360.

Saavedra CA, Chapman N, Wijsman EM, Horowitz ST, Rosen DR (2000) Linkage of hereditary distal myopathy with desmin accumulation to 2q. Human Heredity 50:166-170.

Daw EW, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM (2000) The number of trait loci in late-onset Alzheimer's disease. The American Journal of Human Genetics 66:196-204.


1999
Schaid DJ, Buetow K, Weeks DE, Wijsman E, Guo S-W, Ott J, Dahl C (1999) Discovery of cancer susceptibility genes: study designs, analytic approaches, and trends in technology. Journal of the National Cancer Institute Monographs 26:1-16.

Daw EW, Kumm J, Snow GL, Thompson EA, Wijsman EM (1999) MCMC methods for genome screening. In: Goldin L, Amos CI, Chase GA, Goldstein AM, Jarvik GP, Martinez MM, Suarez BK, Weeks DE, Wijsman EM, MacCluer JW. Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases. Genetic Epidemiology 17(suppl 1):S133-S138.

Sjoberg G, Saavedra-Matiz CA, Rosen DR, Wijsman EM, Borg K, Horowitz SH, Sejersen T (1999) A missense mutation in the desmin rod domain is associated with autosomal dominant distal myopathy, and exerts a dominant negative effect on filament formation. Human Moleular Genetics 8:2191-2198.

Daw EW, Heath SC, Wijsman EM (1999) Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer pedigrees. American Journal of Human Genetics 64:839-851.

Austin MA, Stephens K, Walden CE, Wijsman E (1999) Linkage analysis of candidate genes and the small, dense low-density lipoprotein phenotype. Atherosclerosis. 142:79-87

Hokanson JE, Brunzell JD, Jarvik GP, Wijsman EM, Austin MA (1999) Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. American Journal of Human Genetics 64:608-618.


1998
Chapman NH, Wijsman EM (1998) Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility. American Journal of Human Genetics 63:1872-1885.

Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD (1998) Tau is a candidate gene for chromosome 17 frontotemporal dementia. Annals of Neurology 43:815-825.

Snow GL, Wijsman EM (1998) Pedigree analysis package (PAP) vs. MORGAN: Model selection and hypothesis testing on a large pedigree. Genetic Epidemiology 15:355-369.

Li H, Thompson EA, Wijsman EM (1998) Semiparametric estimation of major gene effects for age of onset. Genetic Epidemiology 15:279-298.

Raskind WH, Conrad EU, Matsushita M, Wijsman EM, Wells DE, Chapman N, Sandell LJ, Wagner JH, Houck J (1998) Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostoses. Human Mutation 11:231-239.

Wijsman EM, Brunzell JB, Jarvik GP, Austin MA, Motulsky AG, Deeb SS (1998) Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex. Arteriosclerosis, Thrombosis, and Vascular Biology. 18:215-226.


1997
Bird TD, Wijsman EM, Nochlin D, Leehey M, Sumi SM, Payami H, Poorkaj P, Nemens E, Raskind M, Schellenberg GD (1997) Chromosome 17 and hereditary dementia: linkage studies in three non-Alzheimer families and kindreds with late-onset FAD. Neurology 48:949-954.

Berninger V, Raskind W, McCutchen D, Richards T, Cunningham A, Nolen S, Wijsman E, Dager S, Corina D, Abbott R (1997) Educational and biological links to learning disabilities. Perspectives vol 23, no. 4.

Yu C-E, Oshima J, Wijsman EM, Nakura J, Miki T, Piussan C, Matthews S, Fu Y-H, Mulligan J, Martin GM, Schellenberg GD, and members of the International Werner's Syndrome Collaborative Group (1997) Mutations in the consensus helicase domains of the Werner's syndrome gene. American Journal of Human Genetics 60:330-341.

Graham J, Chapman NH, Goddard KAB, Goode EL, Wijsman EM, Jarvik GP (1997) Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees. Genetic Epidemiology 14:999-1004.

Heath SC, Snow GL, Thompson EA, Tseng C, Wijsman EM (1997) MCMC segregation and linkage analysis. Genetic Epidemiology 14:1011-1016.

Wijsman EM (1997) Monte Carlo Methods and model selection in genetic analysis. Animal Biotechnology 8:129-144.

Wijsman EM, Amos CI (1997) Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions. Genetic Epidemiology 14:719-736.

Edland S, Wijsman EM, Schoder-Ehri G, Leverenz J (1997) Little evidence of reduced survival to adulthood of apoE e4 homozygotes in Down's syndrome. NeuroReport 8:3463-3465.


1996
Marcovina SM, Albers JJ, Wijsman EM, Zhang ZH, Chapman NH, Kennedy H (1996) Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans. Journal of Lipid Research 37:2569-2585.

Olshen AB, Wijsman EM (1996) Pedigree Analysis Package vs. MIXD: fitting the mixed model on a large pedigree. Genetic Epidemiology 13:91-106.

Jarvik GP, Larson EB, Goddard K, Kukull WA, Schellenberg GD, Wijsman EM (1996) Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. American Journal of Human Genetics 58:191-200.

Payami H, Zareparsi S, Montee KR, Sexton GJ, Kaye JA, Bird TD, Yu C-E, Wijsman EM, Heston LL, Litt M, Schellenberg GD (1996) Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease (AD): a possible clue to the higher incidence of Alzheimer Disease in women. American Journal of Human Genetics 58:803-811.

Edland SD, Silverman JM, Peskind ER, Tsuang D, Wijsman E, Morris JC (1996) Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance. Neurology 47:254-256.

Goddard KAB, Yu C-E, Oshima J, Miki T, Nakura J, Piussan C, Martin GM, Schellenberg GD, Wijsman EM, and members of the International Werner's Syndrome Collaborative Group (1996) Towards localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers. American Journal of Human Genetics 58:1286-1302.

Yu C-E, Oshima J, Fu Y-H, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD (1996) Positional cloning of the Werner's syndrome gene. Science 272:258-262.

Nakura J, Miki T, Le L, Mitsuda N, Zhao Y, Kihara K, Yu C-E, Oshima J, Fukuchi K, Wijsman EM, Schellenberg GD, Martin GM, Murano S, Hashimoto K, Fujiwara Y, Ogihara T (1996) Narrowing the position of the Werner syndrome locus by homozygosity analysis - extension of homozygosity. Genomics 36:130-141.


1995
Jarvik GP, Kukull WA, Schellenberg GD, Yu C, Larson EB, Wijsman EM (1995) Interactions of Apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer disease in a case-control study. Neurology 45:1092-1096.

Stephens K, Zlotogorski A, Smith L, Ehrlich P, Wijsman E, Livingston RJ, Sybert VP (1995) Epidermolysis bullosa simplex: a keratin 5 mutation is a fully dominant allele in epidermal cytoskeleton function. American Journal of Human Genetics 56:577-585.

Goddard KAB, Jarvik GP, Graham J, McNeney B, Hsu L, Siegmund K, Grosser S, Olson J, Wijsman EM (1995) Analysis of quantitative risk factors for a common oligogenic disease. Genetic Epidemiology 12:759-764.

Querfurth H, Wijsman E, St. George-Hyslop PH, Selkoe D (1995) bAPP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Molecular Brain Research 28:319-337.

Koller WC, Glatt SL, Hubble JP, Paolo A, Tröster AI, Handler MS, Horvat RT, Martin C, Schmidt K, Karst A, Wijsman EM, Yu C-E, Schellenberg GD (1995) Apolipoprotein E genotypes in Parkinson's disease with and without dementia. Annals of Neurology 37:242-245.

Brunzell JD, Austin MA, Deeb SS, Hokanson JE, Jarvik GP, Nevin DN, Wijsman E, Zambon A, Motulsky AG (1995) Familial combined hyperlipidemia and genetic risk for atherosclerosis. Atherosclerosis X:624-627.

Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KAB, Weber, JL, Bird TD, Schellenberg GD (1995) A familial Alzheimer's disease locus on chromosome 1. Science 269:970-973.

Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu C-E, Jondro PD, Schmidt SD, Wang K, Crowley AC, Fu Y-H, Guenette SY, Galas D, Nemens E, Wijsman EM, Bird TD, Schellenberg GD, Tanzi RE (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-977.

Levy-Lahad E, Lahad A, Wijsman EM, Bird TD, Schellenberg GD (1995) ApoE genotypes and age of onset in early-onset familial Alzheimer's disease. Annals of Neurology 38:678-680.


1994
Commenges D, Olson J, Wijsman E (1994) The weighted rank pairwise correlation statistic for linkage analysis: simulation study and application to Alzheimer's disease. Genetic Epidemiology 11:201-212.

Palmer SE, Dale DC, Livingston RJ, Wijsman EM, Stephens K (1994) Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5. Human Genetics, 93:195-197.

Lin S, Thompson EA, Wijsman EM (1994) Finding non-communicating sets for Markov chain Monte Carlo estimations on pedigrees. American Journal of Human Genetics 54:695-704.

Yu C-E, Payami H, Olson JM, Boehnke M, Wijsman EM, Orr HT, Kukull WA, Goddard KAB, Nemens E, White JA, Alonso ME, Taylor TD, Ball MJ, Kaye J, Morris J, Chui H, Sadovnick AD, Martin GM, Larson EB, Heston LL, Bird TD, Schellenberg GD (1994) The Apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer's disease. American Journal of Human Genetics 54:631-642.

Palmer SE, Scherer SW, Kukolich M, Wijsman EM, Tsui L-C, Stephens K, Evans JP (1994) Evidence for locus heterogeneity in human autosomal dominant split hand/split foot malformation. American Journal of Human Genetics 55:21-26.

Yu C-E, Oshima J, Goddard KAB, Miki T, Nakura J, Ogihara T, Poot M, Hoehn H, Fraccaro M, Piussan C, Martin GM, Schellenberg GD, Wijsman EM (1994) Linkage disequilibrium and haplotype studies of chromosome 8p 11.1-21.1 markers and Werner's sydrome. American Journal of Human Genetics 55:356-364.

Olson JM, Wijsman EM (1994) Design and sample size considerations in the detection of linkage disequilibrium with a disease locus. American Journal of Human Genetics 55:574-580.

Lin S, Thompson E, Wijsman E (1994) An algorithm for Monte Carlo estimation of genotype probabilities on complex pedigrees. Annals of Human Genetics 58:343-357.

Nakura J, Wijsman EM, Miki T, Kamino K, Yu C-E, Oshima J, Fukuchi K, Weber JL, Piussan C, Malaragno MI, Epstein CJ, Scappaticci S, Fraccaro M, Matsumura T, Murano S, Yoshida S, Fujiwara Y, Saida T, Ogihara T, Martin GM, Schellenberg GD. (1994) Homozygosity mapping of the Werner's syndrome locus (WRN). Genomics 23:600-608.

Jarvik GP, Brunzell JD, Austin MA, Krauss RM, Motulsky AG, Wijsman EM (1994) Genetic predictors of familial combined hyperlipidemia in four large pedigrees: influence of apolipoprotein B level major locus predicted genotype and low density lipoprotein subclass phenotype. Arteriosclerosis and Thrombosis 14:1687-1694.


1993
Jarvik GP, Wijsman E, Little RER, Albers JJ, Motulsky AG, Brunzell JB (1993) Host and environmental effects on plasma apolipoprotein B. International Journal of Clinical and Laboratory Research. 23:215-220.

Olson JM, Wijsman EM (1993) Linkage between quantitative trait and marker loci: methods using all relative pairs. Genetic Epidemiology 10:87-102.

Lin S, Thompson E, Wijsman E (1993) Achieving irreducibility of the Markov chain Monte Carlo method applied to pedigree data. IMA Journal of Mathematics Applied in Medicine and Biology 10:1-17.

Wijsman EM, Bird TD, Martin GM, Schellenberg GD (1993) The Seattle Alzheimer's disease data set. Genetic Epidemiology 10:365-369.

Wijsman EM (1993) Genetic analysis of Alzheimer's disease: summary of GAW8. Genetic Epidemiology 10:349-360.

Thompson EA, Lin S, Olshen AB, Wijsman EM (1993) Monte Carlo segregation and linkage analysis of a large hypercholesterolemia pedigree. Genetic Epidemiology 10:677-682.

Stephens K, Sybert VP, Wijsman EM, Ehrlich P, Spencer A (1993) A keratin 14 mutational hot spot for epidermolysis bullosa simplex, Dowling-Meara: implications for diagnosis. Journal of Investigative Dermatology 101:240-243.

Bonnycastle LLC, Yu C-E, EM Wijsman EM, Orr HT, Patterson D, Clancy KP, Goddard KAB, Alonso ME, Nemens E, White JA, Heston LL, Martin GM, Bird TD, Schellenberg GD (1993) The c-fos gene and early-onset familial Alzheimer's disease. Neuroscience Letters 163:33-36.

Schellenberg GD, Payami H, Wijsman EM, Orr HT, Goddard KAB, Anderson L, Nemens E, White JA, Alonso ME, Ball MJ, Kaye J, Morris JC, Chui H, Sadovnick AD, Heston LL, Martin GM, Bird TD (1993) Chromosome 14 and late-onset familial Alzheimer disease. American Journal of Human Genetics 53:619-628.

Cook A, Raskind W, Blanton SH, Pauli R, Gregg RG, Francomano C, Puffenberger E, Conrad EU, Schmale G, Schellenberg G, Wijsman E, Hect J, Wells DE, Wagner JH (1993) Genetic heterogeneity in families with hereditary multiple exostoses. American Journal of Human Genetics 53:71-79.

Nakura J, Miki T, Nagano K, Kihara K, Ye L, Kamino K, Fujiwara Y, Yoshida S, Murano S, Fukuchi K-I, Wijsman EM, Martin GM, Schellenberg GD, Ogihara T (1993) Close linkage of the gene for Werner's syndrome to ANK1 and D8S87 on the short arm of chromosome 8. Gerontology 39 (suppl):11-15.


1992
Blossey H, Guo SW, McKnight B, Tierney C, Thompson E, Wijsman E (1992) Linkage analysis of malignant melanoma with the chromosome 1 markers D1S47 and PND. Cytogenetics and Cell Genetics 59:182-184.

Schellenberg GD, Boehnke M, Wijsman EM, Moore DK, Martin GM, Bird TD (1992) Genetic association and linkage analysis of the Apo CII locus and familial Alzheimer's disease. Annals of Neurology 31:223-227.

Austin MA, Horowitz H, Wijsman E, Krauss RM, Brunzell J (1992) Bimodality of Plasma Apolipoprotein B levels in Familial Combined Hyperlipidemia. Atherosclerosis 92:67-77.

Deeb SS, Failor RA, Brown BG, Brunzell JD, Albers JJ, Motulsky AG, Wijsman E (1992) Association of Apolipoprotein B gene variants with Plasma apoB and LDL Cholesterol Levels. Human Genetics 88:463-470.

Kamino K, Orr HT, Payami H, Wijsman EM, Anderson L, O'dahl S, Nemens E, White JA, Sadovnick AD, Ball MJ, Warren A, Sharma V, Kukull W, Larson E, Heston LL, Martin GM, Bird TD, Schellenberg GD (1992) Linkage and mutational analysis of familial Alzheimer's disease kindreds for the APP gene region. American Journal of Human Genetics 51:998-1014.

Wijsman EM. (1992) Principles of linkage analysis applied to genetic mapping of familial Alzheimer's disease. Current Science 63:487-491.

Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, White JA, Bonnycastle L, Weber JL, Alonso ME, Potter H, Heston LL, Martin GM (1992) Genetic linkage evidence for a familial Alzheimer disease locus on chromosome 14. Science 258:668-671.


1991
Raskind WH, Wijsman EM, Pagon RA, Cox TC, Bawden MJ, May BK, Bird TD (1991) X-linked sideroblastic anemia and ataxia: linkage to phosphoglycerate kinase at Xq13. The American Journal of Human Genetics 48:335-341.

Schellenberg GD, Pericak-Vance MA, Wijsman EM, Moore DK, Gaskell Jr. PC, Yamaoka LA, Bebout JL, Anderson L, Welsh KA, Clark CM, Martin GM, Roses AD, Bird TD (1991) Linkage analysis of familial Alzheimer's disease using chromosome 21 markers. The American Journal of Human Genetics 48:563-583.

Wijsman, EM. (1991) Recurrence risk of a new dominant mutation in children of unaffected parents. The American Journal of Human Genetics 48:654-661.

Schellenberg GD, Anderson L, O'dahl S, Wijsman EM, Sadovnick AD, Ball MJ, Larson EB, Kukull WA, Martin GM, Roses AD, Bird TD (1991) APP717, APP693, and PRIP gene mutations are rare in Alzheimer's disease. The American Journal of Human Genetics 49:511-517.

Austin MA, Wijsman E, Guo S, Krauss RM, Brunzell JD, Deeb S (1991) Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia. Genetic Epidemiology 8:287-297.


1990
Martin GM, Schellenberg GD, Wijsman EM, Bird TD (1990) Dominant Susceptibility Genes. Nature 347:124.


1989
Bird TD, Schellenberg GD, Wijsman EM, Martin GM (1989) Evidence for etiologic heterogeneity in Alzhheimer's disease. Neurobiology of Aging. 10:432-434.

Schellenberg GD, Bird TD, Wijsman EM, Moore DK, Martin GM (1989) The genetics of Alzheimer's Disease. Biomedicine and Pharmacotherapy 43:463-468.


1988
Bowcock AM, Hebert JM, Wijsman E, Gadi I, Cavalli-Sforza LL, Boyd CD (1988) High recombination between two physically close human basement membrane collagen genes at the distal end of chromosome 13q. Proceedings of the National Academy of Sciences USA 85:2701-2705.

Schellenberg GD, Bird TD, Wijsman EM, Moore DK, Boehnke M, Bryant EM, Lampe TH, Nochlin D, Sumi M, Deeb SS, Beyreuther K, Martin GM(1988) Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 241:1507-1510.

Darby JK, Willems PJ, Nakashima P, Johnsen J, Ferrell RE, Wijsman EM, Gerhard D, Dracopoli NC, Housman D, Henke J, Fowler ML, Shows TB, O'Brien JS, Cavalli-Sforza LL (1988) Restriction analysis of the structural alpha-L- fucosidase gene and its linkage to fucosidosis. The American Journal of Human Genetics 43:749-755.


1987
Wijsman EM (1987) A deductive method of haplotype analysis in pedigrees. American Journal of Human Genetics 41:356-373.

Bowcock AM, Hebert JM, Christiano AM, Wijsman E, Cavalli-Sforza LL, Boyd CD (1987) The pro alpha 1 (IV) collagen gene is linked to the D13S3 locus at the distal end of human chromosome 13q. Cytogenetics and Cell Genetics 45:234-236.


1986
Wijsman EM, Neves WA (1986) The use of nonmetric variation in estimating human population admixture: a test case with Brazilian Blacks and Whites. American Journal of Physical Anthropology 70:395-405.


1985
Astolfi P, Pagnacco G, Wijsman EM (1985) Estimation of racial mixture in a native Italian Cattle breed. Journal of Animal Breeding and Genetics 1102:56-64.

Feder J, Yen L, Wijsman E, Wang L, Wilkins L, Schroder J, Spurr N, Cann H, Blumenberg M, Cavalli-Sforza LL (1985) A systematic approach for detecting high frequency restriction fragment length polymorphisms using large genomic probes. American Journal of Human Genetics 37:635-649.


1984
Wijsman EM (1984) The effect of mutagenesis on competitive ability in Drosophila. Evolution 38:571-581.

Wijsman EM, Zei G, Moroni A, Cavalli-Sforza LL (1984) Surnames in Sardinia II. Computation of migration matrices from surname distributions in different periods. Annals of Human Genetics 48:65-78.

Wijsman EM (1984) Techniques for estimating genetic admixture and applications to the problem of the origin of the Icelanders and the Ashkenazi Jews. Human Genetics 67:441-448.

Wijsman EM, Cavalli-Sforza LL (1984) Migration and genetic population structure. Annual Review of Ecology and Systematics, 15:279-301.

Wijsman EM (1984) Optimizing selection of restriction enzymes in the search for DNA variants. Nucleic Acids Research 12:9209-9226.


Book chapters
Wijsman EM (2005) Gene mapping and the transition from STRPs to SNPs. In Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, Vol. 1. (LB Jorde, PFR Little, MJ Dunn, S Subramaniam, eds). John Wiley & Sons, Inc. (2005) pp 389-398.

Wijsman EM (2002) Joint linkage and segregation analysis using Markov chain Monte Carlo methods. In Methods in Molecular Biology: vol. 195: Quantitative trait loci: methods and protocols. (N Camp and A Cox, eds) Humana Press, Inc. pp. 139-161.

Bird TD, Lampe TH, Wijsman EM, Schellenberg GD (1998) Familial Alzheimer's disease: Genetic studies in neurobiology of primary dementia. Association for research in nervous and mental diseases (MF Folstein, ed), American Psychiatric Press, Inc., Washington DC, pp 27-41.

Wijsman, EM (1998) Mendel's Laws. in Encyclopedia of Biostatistics, vol 5, Human Genetics (P Armitage and T Colton, Eds), John Wiley & Sons, Sussex, pp 2568-2569.

Wijsman, EM (1998) Penetrance. in Encyclopedia of Biostatistics, vol 5, Human Genetics (P Armitage and T Colton, Eds), John Wiley & Sons, Sussex, pp 3321-3323.

Bird TD, Lampe TH, Wijsman EM, Schellenberg GD (1998) Familial Alzheimer's disease: Genetic studies. in Neurobiology of primary dementia (MF Folstein, Ed), Association for Research in Nervous and Mental Diseases, American Psychiatric Press, Inc., Washington, DC. pp. 27-41

Wijsman EM (1997) Association vs. linkage analysis in mental disorders. in Handbook of Psychiatric genetics, K Blum and E Noble, eds., CRC Press, Inc., Boca Raton, pp. 7-23.

Bird, TD, EM Nemens, D Nochlin, SM Sumi, EM Wijsman, and GD Schellenberg (1992) Familial Alzheimer's disease in Germans from Russia: A model of genetic heterogeneity in Alzheimer's disease. in Heterogeneity of Alzheimer's disease (F Boller, F Forette, Z Khachaturian, M Poncet, and Y Christen, eds), Springer Verlag, New York, pp. 118-129.

Wijsman EM (1990) Linkage analysis of alcoholism: problems and solutions. in Banbury Report 33: Genetics and Biology of Alcoholism. Cold Spring Harbor Laboratory Press, New York, pp. 317-326.

Schellenberg, GD, EM Wijsman, TD Bird, DK Moore, and GM Martin (1990) Linkage analysis of familial Alzheimer's disease: Genetic heterogeneity and the search for the gene. International Congress Series. Molecular Biology and Genetics of Alzheimer's Disease: Proceedings of the International Symposium on Dementia. eds. T Miyatake, DJ Selkoe, and Y Ihara., pp. 245-254.

Bird, TD, TH Lampe, EJ Nemens, SM Sumi, D Nochlin, GD Schellenberg, EM Wijsman (1988) Characteristics of familial Alzheimer's disease in nine kindreds of Volga German ancestry. in Alzheimer's disease and related disorders. Alan R. Liss, Inc., New York, pp 229-234.

Wijsman, EM (1986) Estimation of genetic admixture in the Pygmies. in African Pygmies (LL Cavalli-Sforza, ed), Academic Press, Inc., New York, pp. 347-358.


Letters to the editor/Technical Reports/Symposium reports
Heather J Cordell, Mariza de Andrade, Marie-Claude Babron, Christopher W Bartlett, Joseph Beyene, Heike Bickebör, Robert Culverhouse, Adrienne Cupples, E Warwick Daw, JoséDupuis, Catherine T Falk, Saurabh Ghosh, Katrina A Goddard, Ellen L Goode, Elizabeth R Hauser, Lisa J Martin, Maria Martinez, Kari E North, Nancy L Saccone, Silke Schmidt, William Tapper, Duncan Thomas, David Tritchler, Veronica J Vieland, Ellen M Wijsman, Marsha A Wilcox, John S Witte, Qiong Yang, Andreas Ziegler, Laura Almasy and Jean W MacCluer (eds) Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci . BMC Proceedings, Volume 1 (Suppl 1), S1-S168 (2007).

Wijsman EM, Almasy L, Amos CI, Borecki I, Falk CT, King TM, Martinez MM, Meyers D, Neuman R, Olson JM, Rich S, Spence MA, Thomas DC, Vieland VJ, Witte JS, MacCluer JW, eds., (2001). Genetic Analysis Workshop 12. Analysis of complex genetic traits: Applications to asthma and simulated data. Genetic Epidemiology, Volume 21(Suppl 1), pgs. S1-S853.

Goldin L, Amos CI, Chase GA, goldstein AM, Jarvik GP, Martinez MM, Suarez BK, Weeks DE, Wijsman EM, MacCluer JW (1999). Genetic Analysis Workshop 11: Analysis of genetic and environmental factors in common diseases. Genetic Epidemiology, vol 17, supplement 1.

Wijsman EM (1998) Penetrance - what is it? Proceedings of the 1998 American Statistical Association meetings, Epidemiology section, pp 16-23.

Wijsman EM, Lin S (1995) Monte Carlo methods in genetic epidemiology: opportunities and problems. Proceedings of the 1995 American Statistical Association meetings, Epidemiology section, pp 38-47.

Evans JP, Palmer S, Scherer SW, Kukolich M, Wijsman EM, Tsui L-C, Stephens K (1995) Letter to the Editor regarding "Heterogeneity of the autosomal dominant split hand/split foot malformation". American Journal Of Human Genetics 56:342-343.

Wijsman EM, Lin S. (1995) Monte Carlo methods in genetic epidemiology: opportunities and problems. Proceedings of the 1995 American Statistical Association meetings, Epidemiology section, pp 38-47.

Payami H, Montee K, Kaye J, Bird T, Yu C-E, Wijsman EM, Schellenberg G (1994) Alzheimer disease, Apolipoprotein E4 dosage, and gender. JAMA 271:1316-1317.

Jarvik GP and Wijsman EM (1994) Letter to the editor. Nature Genetics 8:115.

Schellenberg, G.D., G.M. Martin, E.M. Wijsman, J. Nakura, T. Miki, and T. Ogihara (1992) Homozygosity mapping and Werner's syndrome. Lancet 339:1002.

Thompson, EA and EM Wijsman (1990) The Gibbs sampler on extended pedigrees: Monte Carlo methods for the genetic analysis of complex traits. Technical Report no. 193, Department of Statistics, University of Washington.

Wijsman EM (1985) Reply to Gilbert. Evolution 39:941-943.

Wijsman EM (1981) The effect of ether on mating behavior in D. simulans y w. Drosophila Information Service. 56:158.


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Last updated: Friday, 05-Sep-2014 16:02:46 PDT