Table of Nominal Mass Differences for Single Substitutions Among the 20 Common Amino Acids

Mass Possible Substitutions
-129 Trp->Gly
-115 Trp->Ala
-106 Tyr->Gly
- 99 Arg->Gly, Trp->Ser
- 92 Tyr->Ala
- 90 Phe->Gly
- 89 Trp->Pro
- 87 Trp->Val
- 85 Arg->Ala, Trp->Thr
- 83 Trp->Cys
- 80 His->Gly
- 76 Tyr->Ser, Phe->Ala
- 74 Met->Gly
- 73 Trp->Ile/Leu
- 72 Trp->Asn, Glu->Gly
- 71 Lys/Gln->Gly, Trp->Asp
- 69 Arg->Ser
- 66 Tyr->Pro, His->Ala
- 64 Tyr->Val
- 62 Tyr->Thr
- 60 Phe->Ser, Met->Ala, Tyr->Cys
- 59 Arg->Pro
- 58 Glu->Ala, Asp->Gly, Trp->Lys/Gln
- 57 Lys/Gln->Ala, Asn->Gly, Arg->Val, Trp->Glu
- 56 Ile/Leu->Gly
- 55 Arg->Thr, Trp->Met
- 53 Arg->Cys
- 50 Phe->Pro, His->Ser, Tyr->Ile/Leu
- 49 Tyr->Asn, Trp->His
- 48 Phe->Val, Tyr->Asp
- 46 Phe->Thr, Cys->Gly
- 44 Met->Ser, Asp->Ala, Thr->Gly, Phe->Cys
- 43 Asn->Ala, Arg->Ile/Leu
- 42 Val->Gly, Ile/Leu->Ala, Glu->Ser, Arg->Asn
- 41 Lys/Gln->Ser, Arg->Asp
- 40 Pro->Gly, His->Pro
- 39 Trp->Phe
- 38 His->Val
- 36 His->Thr
- 35 Tyr->Lys/Gln
- 34 Met->Pro, His->Cys, Phe->Ile/Leu, Tyr->Glu
- 33 Phe->Asn
- 32 Cys->Ala, Glu->Pro, Met->Val, Phe->Asp, Tyr->Met
- 31 Lys/Gln->Pro
- 30 Ser->Gly, Thr->Ala, Glu->Val, Met->Thr, Trp->Arg
- 29 Lys/Gln->Val
- 28 Val->Ala, Asp->Ser, Glu->Thr, Met->Cys, Arg->Lys/Gln
- 27 Asn->Ser, Lys/Gln->Thr, Arg->Glu
- 26 Pro->Ala, Ile/Leu->Ser, Glu->Cys, Tyr->His
- 25 Lys/Gln->Cys, Arg->Met
- 24 His->Ile/Leu
- 23 His->Asn, Trp->Tyr
- 22 His->Asp
- 19 Phe->Lys/Gln, Arg->His
- 18 Asp->Pro, Met->Ile/Leu, Phe->Glu
- 17 Asn->Pro, Met->Asn
- 16 Ser->Ala, Cys->Ser, Ile/Leu->Pro, Asp->Val, Glu->Ile/Leu, Met->Asp, Phe->Met, Tyr->Phe
- 15 Asn->Val, Lys/Gln->Ile/Leu, Glu->Asn
- 14 Ala->Gly, Thr->Ser, Ile/Leu->Val, Asp->Thr, Glu->Asp, Lys/Gln->Asn
- 13 Asn->Thr, Lys/Gln->Asp
- 12 Val->Ser, Ile/Leu->Thr, Asp->Cys
- 11 Asn->Cys
- 10 Pro->Ser, Ile/Leu->Cys, Phe->His
- 9 His->Lys/Gln, Arg->Phe
- 8 His->Glu
- 7 Tyr->Arg
- 6 Cys->Pro, His->Met
- 4 Thr->Pro, Cys->Val
- 3 Met->Lys/Gln
- 2 Val->Pro, Thr->Val, Cys->Thr, Asp->Ile/Leu, Met->Glu
- 1 Asn->Ile/Leu, Asp->Asn, Glu->Lys/Gln
1 Ile/Leu->Asn, Asn->Asp, Lys/Gln->Glu
2 Pro->Val, Val->Thr, Thr->Cys, Ile/Leu->Asp, Glu->Met
3 Lys/Gln->Met
4 Pro->Thr, Val->Cys
6 Pro->Cys, Met->His
7 Arg->Tyr
8 Glu->His
9 Lys/Gln->His, Phe->Arg
10 Ser->Pro, Cys->Ile/Leu, His->Phe
11 Cys->Asn
12 Ser->Val, Thr->Ile/Leu, Cys->Asp
13 Thr->Asn, Asp->Lys/Gln
14 Gly->Ala, Ser->Thr, Val->Ile/Leu, Thr->Asp, Asn->Lys/Gln, Asp->Glu
15 Val->Asn, Ile/Leu->Lys/Gln, Asn->Glu
16 Ala->Ser, Ser->Cys, Pro->Ile/Leu, Val->Asp, Ile/Leu->Glu, Asp->Met, Met->Phe, Phe->Tyr
17 Pro->Asn, Asn->Met
18 Pro->Asp, Ile/Leu->Met, Glu->Phe
19 Lys/Gln->Phe, His->Arg
22 Asp->His
23 Asn->His, Tyr->Trp
24 Ile/Leu->His
25 Cys->Lys/Gln, Met->Arg
26 Ala->Pro, Ser->Ile/Leu, Cys->Glu, His->Tyr
27 Ser->Asn, Thr->Lys/Gln, Glu->Arg
28 Ala->Val, Ser->Asp, Thr->Glu, Cys->Met, Lys/Gln->Arg
29 Val->Lys/Gln
30 Gly->Ser, Ala->Thr, Val->Glu, Thr->Met, Arg->Trp
31 Pro->Lys/Gln
32 Ala->Cys, Pro->Glu, Val->Met, Asp->Phe, Met->Tyr
33 Asn->Phe
34 Pro->Met, Cys->His, Ile/Leu->Phe, Glu->Tyr
35 Lys/Gln->Tyr
36 Thr->His
38 Val->His
39 Phe->Trp
40 Gly->Pro, Pro->His
41 Ser->Lys/Gln, Asp->Arg
42 Gly->Val, Ala->Ile/Leu, Ser->Glu, Asn->Arg
43 Ala->Asn, Ile/Leu->Arg
44 Gly->Thr, Ala->Asp, Ser->Met, Cys->Phe
46 Gly->Cys, Thr->Phe
48 Val->Phe, Asp->Tyr
49 Asn->Tyr, His->Trp
50 Ser->His, Pro->Phe, Ile/Leu->Tyr
53 Cys->Arg
55 Thr->Arg, Met->Trp
56 Gly->Ile/Leu
57 Gly->Asn, Ala->Lys/Gln, Val->Arg, Glu->Trp
58 Gly->Asp, Ala->Glu, Lys/Gln->Trp
59 Pro->Arg
60 Ala->Met, Ser->Phe, Cys->Tyr
62 Thr->Tyr
64 Val->Tyr
66 Ala->His, Pro->Tyr
69 Ser->Arg
71 Gly->Lys/Gln, Asp->Trp
72 Gly->Glu, Asn->Trp
73 Ile/Leu->Trp
74 Gly->Met
76 Ala->Phe, Ser->Tyr
80 Gly->His
83 Cys->Trp
85 Ala->Arg, Thr->Trp
87 Val->Trp
89 Pro->Trp
90 Gly->Phe
92 Ala->Tyr
99 Gly->Arg, Ser->Trp
106 Gly->Tyr
115 Ala->Trp
129 Gly->Trp


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Last Updated January 7, 2000













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