=============================== MCDS Version 2.01 19-JAN-2006 =============================== 9.454 running time (min) 1141749120 seed 100000 number of cells RADIATION TYPE: 4He 4.0000E+00 Kinetic energy (MeV) >= 1.9882E+00 MeV 3.7264E+03 Rest mass energy (MeV) 4.6297E-02 Speed (beta=v/c) 1.7700E+03 (Zeff/beta)^2 <= 3200 DAMAGE FORMATION AND CLUSTERING: 41800 segment length, nseg (bp per cell per Gy) 1300 number of strand breaks, sigSb (per cell per Gy) 3900 number of base damages, sigBd (per cell per Gy) 3.0 base damage to strand break ratio, f 9 minimum distance between clusters, Nmin (bp) 10 maximum distance between two Sb to compose a DSB, Ndsb (bp) 0.0 fraction Bl/Bd DMSO SIMULATION: 5.0000E-01 fraction of non-scavengeable DNA damage 5.0000E-01 concentration at half-level (mol dm^-3) 0.0000E+00 DMSO concentration (mol dm^-3) % DAMAGE YIELD (See Nikjoo et al. 1997 Int.J.Radiat.Biol. 71, 467-483; Nikjoo et al. 2001 Radiat.Res. 156, 577-583) =================================================================================================================== 47.776 BD - one or more Bd (no Sb) 33.266 SSB - Sb (no auxilary damage) 7.187 SSB+ - two Sb on the same strand 2.937 2SSB - two or more Sb on opposite strands separated by at least 10 bp 4.322 DSB - two Sb on opposite strands with a separation <= 10 bp 2.571 DSB+ - DSB accompanied by one (or more) additional Sb within 10 bp separation 1.941 DSB++ - more than one DSB whether within the 10 bp separation or further apart 23.332 SSBc - fraction of complex damage (SSB+ and 2SSB) among SSBs 82.456 SSBcb - fraction of complex damage (SSB+ and 2SSB) among SSBs; base damage included 51.076 DSBc - fraction of complex damage (DSB+ and DSB++) among DSBs 92.145 DSBcb - fraction of complex damage (DSB+ and DSB++) among DSBs; base damage included =================================================================================================================== NUMBER OF CLUSTERS (per cell per Gy) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.20800E+02 3.24253E-02 3.62452E+02 5.47674E-02 4.83252E+02 6.21826E-02 2 1.10125E+01 1.03525E-02 1.36218E+02 3.49522E-02 1.89274E+02 4.08955E-02 3.36504E+02 5.41354E-02 3 1.79481E+01 1.31095E-02 1.17274E+02 3.30310E-02 9.86585E+01 2.98549E-02 2.33880E+02 4.59757E-02 4 1.97316E+01 1.36828E-02 9.14105E+01 2.92661E-02 5.14070E+01 2.16786E-02 1.62549E+02 3.82167E-02 5 1.85467E+01 1.32545E-02 6.75846E+01 2.52020E-02 2.67908E+01 1.58250E-02 1.12922E+02 3.19474E-02 6 1.60730E+01 1.23644E-02 4.84741E+01 2.13798E-02 1.39648E+01 1.15578E-02 7.85119E+01 2.66432E-02 7 1.32665E+01 1.12904E-02 3.40181E+01 1.79436E-02 7.26829E+00 8.36448E-03 5.45529E+01 2.22473E-02 8 1.06006E+01 1.01103E-02 2.35303E+01 1.49076E-02 3.78063E+00 6.05616E-03 3.79115E+01 1.85792E-02 9 8.26100E+00 8.91179E-03 1.60706E+01 1.23350E-02 1.97253E+00 4.41001E-03 2.63041E+01 1.55504E-02 10 6.35326E+00 7.81004E-03 1.08727E+01 1.01859E-02 1.02910E+00 3.19747E-03 1.82550E+01 1.29767E-02 11 4.82451E+00 6.83614E-03 7.35782E+00 8.41928E-03 5.33900E-01 2.30984E-03 1.27162E+01 1.09311E-02 12 3.61085E+00 5.93470E-03 4.92695E+00 6.91701E-03 2.75850E-01 1.65704E-03 8.81365E+00 9.18076E-03 13 2.68146E+00 5.11056E-03 3.29885E+00 5.67229E-03 1.45880E-01 1.20350E-03 6.12619E+00 7.66011E-03 14 1.98243E+00 4.41604E-03 2.19905E+00 4.65032E-03 7.51600E-02 8.67478E-04 4.25664E+00 6.41091E-03 15 1.45575E+00 3.78832E-03 1.46714E+00 3.79860E-03 3.97600E-02 6.29758E-04 2.96265E+00 5.35821E-03 16 1.05475E+00 3.23030E-03 9.67690E-01 3.10064E-03 2.05100E-02 4.51991E-04 2.04295E+00 4.48036E-03 17 7.69910E-01 2.75952E-03 6.43180E-01 2.52683E-03 1.02200E-02 3.18679E-04 1.42331E+00 3.72965E-03 18 5.54280E-01 2.34840E-03 4.27780E-01 2.05570E-03 5.56000E-03 2.35141E-04 9.87620E-01 3.11528E-03 19 4.04560E-01 2.00917E-03 2.82400E-01 1.67545E-03 2.49000E-03 1.57602E-04 6.89450E-01 2.61273E-03 20 2.84200E-01 1.67855E-03 1.88450E-01 1.36755E-03 1.38000E-03 1.17393E-04 4.74030E-01 2.16377E-03 21 2.05750E-01 1.43073E-03 1.24540E-01 1.11405E-03 7.60000E-04 8.71453E-05 3.31050E-01 1.81218E-03 22 1.47980E-01 1.21599E-03 8.19600E-02 9.05999E-04 4.10000E-04 6.40184E-05 2.30350E-01 1.51450E-03 23 1.05110E-01 1.02617E-03 5.48400E-02 7.40764E-04 2.90000E-04 5.38441E-05 1.60240E-01 1.26675E-03 24 7.42500E-02 8.61497E-04 3.60200E-02 6.00024E-04 6.00000E-05 2.44943E-05 1.10330E-01 1.05099E-03 25 5.26100E-02 7.23897E-04 2.38000E-02 4.87379E-04 6.00000E-05 2.44943E-05 7.64700E-02 8.74432E-04 26 3.75900E-02 6.14307E-04 1.55200E-02 3.93945E-04 2.00000E-05 1.41421E-05 5.31300E-02 7.28888E-04 27 2.75900E-02 5.27343E-04 1.05200E-02 3.23874E-04 1.00000E-05 1.00000E-05 3.81200E-02 6.17473E-04 28 1.84500E-02 4.29532E-04 6.63000E-03 2.58188E-04 1.00000E-05 1.00000E-05 2.50900E-02 5.00207E-04 29 1.29800E-02 3.60439E-04 4.63000E-03 2.14677E-04 --- --- 1.76100E-02 4.19524E-04 30 9.76000E-03 3.12487E-04 3.06000E-03 1.74662E-04 --- --- 1.28200E-02 3.57991E-04 31 6.53000E-03 2.54704E-04 1.92000E-03 1.38432E-04 --- --- 8.45000E-03 2.89460E-04 32 4.41000E-03 2.10014E-04 1.40000E-03 1.18239E-04 --- --- 5.81000E-03 2.41584E-04 33 3.25000E-03 1.80540E-04 9.60000E-04 9.79330E-05 --- --- 4.21000E-03 2.05239E-04 34 2.30000E-03 1.51484E-04 6.60000E-04 8.12140E-05 --- --- 2.96000E-03 1.71793E-04 35 1.80000E-03 1.34788E-04 3.50000E-04 5.91507E-05 --- --- 2.15000E-03 1.47153E-04 36 1.19000E-03 1.09023E-04 3.50000E-04 5.91507E-05 --- --- 1.54000E-03 1.24806E-04 37 9.40000E-04 9.69085E-05 1.50000E-04 3.87271E-05 --- --- 1.09000E-03 1.04347E-04 38 4.80000E-04 6.92657E-05 1.40000E-04 3.74141E-05 --- --- 6.20000E-04 7.87161E-05 39 3.50000E-04 5.91507E-05 3.00000E-05 1.73203E-05 --- --- 3.80000E-04 6.16327E-05 40 1.80000E-04 4.24228E-05 7.00000E-05 2.64567E-05 --- --- 2.50000E-04 4.99940E-05 41 1.80000E-04 4.24228E-05 4.00000E-05 1.99997E-05 --- --- 2.20000E-04 4.68992E-05 42 2.10000E-04 4.58212E-05 4.00000E-05 1.99997E-05 --- --- 2.50000E-04 4.99940E-05 43 1.10000E-04 3.31646E-05 1.00000E-05 1.00000E-05 --- --- 1.20000E-04 3.46391E-05 44 8.00000E-05 2.82833E-05 --- --- --- --- 8.00000E-05 2.82833E-05 45 2.00000E-05 1.41421E-05 1.00000E-05 1.00000E-05 --- --- 3.00000E-05 1.73203E-05 46 7.00000E-05 2.64567E-05 --- --- --- --- 7.00000E-05 2.64567E-05 47 2.00000E-05 1.41421E-05 --- --- --- --- 2.00000E-05 1.41421E-05 48 --- --- 1.00000E-05 1.00000E-05 --- --- 1.00000E-05 1.00000E-05 49 --- --- --- --- --- --- --- --- 50 2.00000E-05 1.41421E-05 --- --- --- --- 2.00000E-05 1.41421E-05 Total 1.40130E+02 2.81194E-02 6.88379E+02 5.98081E-02 7.57709E+02 6.22069E-02 1.58622E+03 6.45970E-02 ------------------------------------------------------------------------------------------------------------------- NOTES: The damage yields are for an average human cell (genome length = 6E+09 base pairs). The category OTHER includes all classes of single and clustered damage sites that do not contain strand breaks (Sb). SEM - standard error of the mean. CLUSTER COMPOSITION (% Sb) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.00000E+02 0.00000E+00 0.00000E+00 0.00000E+00 2.49976E+01 5.90798E-03 2 1.00000E+02 0.00000E+00 5.36734E+01 3.52656E-03 0.00000E+00 0.00000E+00 2.49992E+01 4.93009E-03 3 7.19105E+01 9.31469E-03 3.88583E+01 3.77608E-03 0.00000E+00 0.00000E+00 2.50015E+01 4.82035E-03 4 5.84437E+01 9.67034E-03 3.18405E+01 4.07813E-03 0.00000E+00 0.00000E+00 2.49981E+01 5.03472E-03 5 5.06925E+01 9.97370E-03 2.78606E+01 4.55854E-03 0.00000E+00 0.00000E+00 2.49981E+01 5.46114E-03 6 4.56843E+01 1.04056E-02 2.53529E+01 5.15382E-03 0.00000E+00 0.00000E+00 2.50047E+01 6.02800E-03 7 4.21828E+01 1.11972E-02 2.36520E+01 5.94171E-03 0.00000E+00 0.00000E+00 2.50034E+01 6.82509E-03 8 3.95988E+01 1.22069E-02 2.24623E+01 6.95868E-03 0.00000E+00 0.00000E+00 2.50092E+01 7.75037E-03 9 3.76049E+01 1.36798E-02 2.15810E+01 8.20783E-03 0.00000E+00 0.00000E+00 2.49935E+01 8.89255E-03 10 3.60062E+01 1.54475E-02 2.09336E+01 9.80229E-03 0.00000E+00 0.00000E+00 2.50023E+01 1.02343E-02 11 3.47289E+01 1.76513E-02 2.04475E+01 1.20620E-02 0.00000E+00 0.00000E+00 2.50120E+01 1.19827E-02 12 3.36605E+01 2.01292E-02 2.00446E+01 1.49115E-02 0.00000E+00 0.00000E+00 2.50013E+01 1.41656E-02 13 3.27569E+01 2.27227E-02 1.97793E+01 1.81226E-02 0.00000E+00 0.00000E+00 2.49852E+01 1.69567E-02 14 3.20109E+01 2.54286E-02 1.95548E+01 2.15748E-02 0.00000E+00 0.00000E+00 2.50078E+01 2.03190E-02 15 3.13560E+01 2.83198E-02 1.93331E+01 2.51126E-02 0.00000E+00 0.00000E+00 2.49762E+01 2.38932E-02 16 3.06909E+01 3.17252E-02 1.92334E+01 2.91828E-02 0.00000E+00 0.00000E+00 2.49697E+01 2.74608E-02 17 3.02867E+01 3.55321E-02 1.91427E+01 3.40722E-02 0.00000E+00 0.00000E+00 2.50334E+01 3.12088E-02 18 2.98187E+01 4.04525E-02 1.89899E+01 3.98786E-02 0.00000E+00 0.00000E+00 2.49419E+01 3.56311E-02 19 2.94960E+01 4.56315E-02 1.89440E+01 4.71464E-02 0.00000E+00 0.00000E+00 2.50498E+01 4.06031E-02 20 2.90954E+01 5.22296E-02 1.88596E+01 5.58840E-02 0.00000E+00 0.00000E+00 2.49474E+01 4.66614E-02 21 2.88272E+01 5.95636E-02 1.87850E+01 6.74745E-02 0.00000E+00 0.00000E+00 2.49710E+01 5.37761E-02 22 2.85052E+01 6.83899E-02 1.86552E+01 7.99867E-02 0.00000E+00 0.00000E+00 2.49474E+01 6.21143E-02 23 2.84915E+01 8.03087E-02 1.87712E+01 9.62469E-02 0.00000E+00 0.00000E+00 2.51098E+01 7.34076E-02 24 2.80789E+01 9.22961E-02 1.87347E+01 1.16596E-01 0.00000E+00 0.00000E+00 2.50168E+01 8.44205E-02 25 2.79423E+01 1.07751E-01 1.87604E+01 1.36001E-01 0.00000E+00 0.00000E+00 2.50640E+01 9.88224E-02 26 2.78492E+01 1.25920E-01 1.87712E+01 1.68224E-01 0.00000E+00 0.00000E+00 2.51721E+01 1.17058E-01 27 2.76933E+01 1.47890E-01 1.88525E+01 2.06099E-01 0.00000E+00 0.00000E+00 2.52350E+01 1.37577E-01 28 2.72048E+01 1.74621E-01 1.85671E+01 2.52675E-01 0.00000E+00 0.00000E+00 2.49028E+01 1.63552E-01 29 2.70391E+01 2.03932E-01 1.86490E+01 3.16307E-01 --- --- 2.48183E+01 1.93559E-01 30 2.71147E+01 2.31456E-01 1.81699E+01 3.56204E-01 --- --- 2.49647E+01 2.23039E-01 31 2.70414E+01 2.77216E-01 1.92204E+01 3.79542E-01 --- --- 2.52644E+01 2.56925E-01 32 2.63885E+01 3.42139E-01 1.84821E+01 5.17167E-01 --- --- 2.44783E+01 3.20620E-01 33 2.61878E+01 3.82394E-01 1.90972E+01 7.02575E-01 --- --- 2.45671E+01 3.65645E-01 34 2.67136E+01 4.41615E-01 1.89840E+01 6.22808E-01 --- --- 2.49901E+01 4.14465E-01 35 2.64884E+01 5.14729E-01 1.82041E+01 9.44966E-01 --- --- 2.51335E+01 5.02583E-01 36 2.67507E+01 5.47611E-01 1.85714E+01 8.95020E-01 --- --- 2.48548E+01 5.36519E-01 37 2.57044E+01 7.28697E-01 2.23423E+01 1.13344E+00 --- --- 2.52418E+01 6.55487E-01 38 2.59320E+01 7.95167E-01 1.65414E+01 1.71011E+00 --- --- 2.38115E+01 8.77853E-01 39 2.64469E+01 1.28214E+00 1.70940E+01 3.41880E+00 --- --- 2.57085E+01 1.27009E+00 40 2.65278E+01 1.77513E+00 1.64286E+01 1.52919E+00 --- --- 2.37000E+01 1.62096E+00 41 2.68293E+01 1.26259E+00 1.95122E+01 2.98718E+00 --- --- 2.54989E+01 1.29108E+00 42 2.50567E+01 1.12182E+00 2.02381E+01 1.53690E+00 --- --- 2.42857E+01 1.02869E+00 43 2.51586E+01 1.53040E+00 2.79070E+01 0.00000E+00 --- --- 2.53876E+01 1.41571E+00 44 2.21591E+01 2.09315E+00 --- --- --- --- 2.21591E+01 2.09315E+00 45 2.00000E+01 2.22222E+00 2.00000E+01 0.00000E+00 --- --- 2.00000E+01 1.28300E+00 46 2.70186E+01 2.76031E+00 --- --- --- --- 2.70186E+01 2.76031E+00 47 2.02128E+01 7.44681E+00 --- --- --- --- 2.02128E+01 7.44681E+00 48 --- --- 1.45833E+01 0.00000E+00 --- --- 1.45833E+01 0.00000E+00 49 --- --- --- --- --- --- --- --- 50 2.90000E+01 3.00000E+00 --- --- --- --- 2.90000E+01 3.00000E+00 Average 5.23502E+01 5.58006E-03 4.69470E+01 2.97483E-03 0.00000E+00 0.00000E+00 2.49992E+01 1.59160E-03 ------------------------------------------------------------------------------------------------------------------- NOTES: (% Sb) is the percentage of lesions that are strand breaks. The number of Sb is ((% Sb)/100)*(# lesions). The number of Bd is (1-(% Sb)/100)*(# lesions). CLUSTER LENGTH (base pairs) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.00000E+00 0.00000E+00 1.00000E+00 0.00000E+00 1.00000E+00 0.00000E+00 2 4.78161E+00 2.67068E-03 4.97953E+00 7.03209E-04 4.96519E+00 5.96647E-04 4.96509E+00 4.47265E-04 3 8.40206E+00 2.71787E-03 9.02965E+00 1.07350E-03 8.94704E+00 1.16729E-03 8.94666E+00 7.54217E-04 4 1.21323E+01 3.17929E-03 1.31014E+01 1.47935E-03 1.29312E+01 1.98741E-03 1.29300E+01 1.10671E-03 5 1.59851E+01 3.84328E-03 1.71582E+01 1.99123E-03 1.69059E+01 3.20056E-03 1.69059E+01 1.53657E-03 6 1.99245E+01 4.65769E-03 2.12143E+01 2.62637E-03 2.08897E+01 5.04414E-03 2.08919E+01 2.05787E-03 7 2.38802E+01 5.66653E-03 2.52586E+01 3.45386E-03 2.48758E+01 8.09278E-03 2.48723E+01 2.72392E-03 8 2.78644E+01 6.96047E-03 2.93041E+01 4.51030E-03 2.88694E+01 1.28156E-02 2.88563E+01 3.54159E-03 9 3.18544E+01 8.54047E-03 3.33509E+01 5.89960E-03 3.28422E+01 1.88284E-02 3.28417E+01 4.56772E-03 10 3.58473E+01 1.06806E-02 3.73832E+01 7.73241E-03 3.68243E+01 2.65933E-02 3.68171E+01 5.87193E-03 11 3.98300E+01 1.32775E-02 4.14323E+01 1.03054E-02 4.08170E+01 3.72123E-02 4.07964E+01 7.54283E-03 12 4.38123E+01 1.64563E-02 4.54596E+01 1.38281E-02 4.48032E+01 5.28954E-02 4.47647E+01 9.74018E-03 13 4.78074E+01 2.00230E-02 4.95367E+01 1.81167E-02 4.87478E+01 7.57465E-02 4.87617E+01 1.27399E-02 14 5.18176E+01 2.39355E-02 5.35807E+01 2.28329E-02 5.27045E+01 1.08822E-01 5.27466E+01 1.63455E-02 15 5.58377E+01 2.85265E-02 5.75972E+01 2.83241E-02 5.67011E+01 1.55018E-01 5.67224E+01 2.06673E-02 16 5.98004E+01 3.38252E-02 6.16040E+01 3.49832E-02 6.08648E+01 2.20193E-01 6.06590E+01 2.55562E-02 17 6.38400E+01 4.00145E-02 6.57405E+01 4.31918E-02 6.48799E+01 3.25040E-01 6.46947E+01 3.08564E-02 18 6.78032E+01 4.75806E-02 6.97168E+01 5.34102E-02 6.83687E+01 4.40575E-01 6.86469E+01 3.70589E-02 19 7.17326E+01 5.62545E-02 7.37377E+01 6.67218E-02 7.28956E+01 7.36181E-01 7.25614E+01 4.45290E-02 20 7.59587E+01 6.80428E-02 7.77410E+01 8.32416E-02 7.58986E+01 9.99539E-01 7.66491E+01 5.40460E-02 21 7.98964E+01 8.21440E-02 8.17916E+01 1.03994E-01 8.15263E+01 1.38355E+00 8.05951E+01 6.56430E-02 22 8.37816E+01 9.92134E-02 8.59271E+01 1.30997E-01 8.43902E+01 1.46707E+00 8.45447E+01 8.01623E-02 23 8.79949E+01 1.17895E-01 8.97829E+01 1.62229E-01 9.05172E+01 1.95303E+00 8.85967E+01 9.64543E-02 24 9.19436E+01 1.45122E-01 9.38841E+01 2.10732E-01 9.10000E+01 4.13924E+00 9.25834E+01 1.20480E-01 25 9.57781E+01 1.74779E-01 9.80992E+01 2.57649E-01 9.78333E+01 5.78168E+00 9.64937E+01 1.45852E-01 26 9.99715E+01 2.10043E-01 1.01690E+02 3.21320E-01 9.90000E+01 0.00000E+00 1.00467E+02 1.76745E-01 27 1.03675E+02 2.46876E-01 1.07071E+02 3.96551E-01 1.10000E+02 0.00000E+00 1.04624E+02 2.11180E-01 28 1.08151E+02 3.13157E-01 1.10565E+02 5.30070E-01 9.60000E+01 0.00000E+00 1.08791E+02 2.70797E-01 29 1.11812E+02 3.82239E-01 1.14758E+02 6.21692E-01 --- --- 1.12588E+02 3.27676E-01 30 1.15294E+02 4.59957E-01 1.18013E+02 7.71186E-01 --- --- 1.15950E+02 3.97350E-01 31 1.20210E+02 5.45465E-01 1.23354E+02 9.94366E-01 --- --- 1.20924E+02 4.80126E-01 32 1.22565E+02 6.50740E-01 1.24800E+02 1.29697E+00 --- --- 1.23120E+02 5.86862E-01 33 1.28759E+02 7.95676E-01 1.31250E+02 1.65792E+00 --- --- 1.29329E+02 7.22185E-01 34 1.29130E+02 1.00171E+00 1.34788E+02 2.04524E+00 --- --- 1.30392E+02 9.10798E-01 35 1.35028E+02 1.16105E+00 1.37914E+02 2.99281E+00 --- --- 1.35500E+02 1.08695E+00 36 1.37487E+02 1.46078E+00 1.43857E+02 1.93123E+00 --- --- 1.38899E+02 1.22656E+00 37 1.44106E+02 1.47553E+00 1.44733E+02 4.04906E+00 --- --- 1.44193E+02 1.38192E+00 38 1.44771E+02 2.02866E+00 1.48429E+02 2.33397E+00 --- --- 1.45597E+02 1.65994E+00 39 1.48029E+02 2.78818E+00 1.44333E+02 9.38675E+00 --- --- 1.47737E+02 2.64244E+00 40 1.53333E+02 2.81685E+00 1.63143E+02 7.79325E+00 --- --- 1.56080E+02 3.01768E+00 41 1.54167E+02 4.15803E+00 1.66250E+02 5.80768E+00 --- --- 1.56364E+02 3.65536E+00 42 1.60286E+02 3.28789E+00 1.77250E+02 1.23988E+01 --- --- 1.63000E+02 3.50048E+00 43 1.71000E+02 6.04679E+00 1.95000E+02 0.00000E+00 --- --- 1.73000E+02 5.87109E+00 44 1.73625E+02 5.86435E+00 --- --- --- --- 1.73625E+02 5.86435E+00 45 1.77000E+02 1.40000E+01 1.96000E+02 0.00000E+00 --- --- 1.83333E+02 1.02686E+01 46 1.78571E+02 5.86701E+00 --- --- --- --- 1.78571E+02 5.86701E+00 47 1.72000E+02 1.50000E+01 --- --- --- --- 1.72000E+02 1.50000E+01 48 --- --- 1.88000E+02 0.00000E+00 --- --- 1.88000E+02 0.00000E+00 49 --- --- --- --- --- --- --- --- 50 1.90500E+02 8.50000E+00 --- --- --- --- 1.90500E+02 8.50000E+00 Average 2.20606E+01 4.07902E-03 1.28294E+01 1.27694E-03 5.32950E+00 7.00999E-04 1.00621E+01 6.97943E-04 ------------------------------------------------------------------------------------------------------------------- NUMBER OF LESIONS DIVIDED BY TWICE THE CLUSTER LENGTH (lesions per nucleotide) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 5.00000E-01 0.00000E+00 5.00000E-01 0.00000E+00 5.00000E-01 0.00000E+00 2 3.21002E-01 2.52058E-04 2.85559E-01 5.49822E-05 2.88190E-01 4.73617E-05 2.88190E-01 3.55688E-05 3 2.23239E-01 9.84884E-05 2.06237E-01 3.44843E-05 2.08467E-01 3.80630E-05 2.08482E-01 2.46237E-05 4 1.92674E-01 6.59335E-05 1.76839E-01 2.72796E-05 1.79610E-01 3.73365E-05 1.79636E-01 2.08272E-05 5 1.76130E-01 5.31614E-05 1.62380E-01 2.42741E-05 1.65315E-01 4.01790E-05 1.65335E-01 1.92683E-05 6 1.65502E-01 4.69264E-05 1.53991E-01 2.34531E-05 1.56863E-01 4.64029E-05 1.56862E-01 1.89385E-05 7 1.58445E-01 4.45981E-05 1.48663E-01 2.41020E-05 1.51369E-01 5.84587E-05 1.51402E-01 1.97459E-05 8 1.53333E-01 4.43690E-05 1.44902E-01 2.57428E-05 1.47456E-01 7.59028E-05 1.47526E-01 2.09925E-05 9 1.49549E-01 4.56868E-05 1.42149E-01 2.85681E-05 1.44617E-01 9.42209E-05 1.44667E-01 2.29341E-05 10 1.46670E-01 4.92175E-05 1.40042E-01 3.24930E-05 1.42443E-01 1.15309E-04 1.42486E-01 2.55712E-05 11 1.44395E-01 5.33967E-05 1.38324E-01 3.79639E-05 1.40613E-01 1.41343E-04 1.40736E-01 2.88553E-05 12 1.42612E-01 5.88398E-05 1.37020E-01 4.56947E-05 1.39225E-01 1.81687E-04 1.39377E-01 3.33329E-05 13 1.41082E-01 6.42824E-05 1.35804E-01 5.42457E-05 1.38285E-01 2.34392E-04 1.38168E-01 3.94120E-05 14 1.39726E-01 7.00541E-05 1.34845E-01 6.23126E-05 1.37294E-01 3.04709E-04 1.37152E-01 4.61474E-05 15 1.38624E-01 7.63697E-05 1.34073E-01 7.06318E-05 1.36448E-01 4.00261E-04 1.36339E-01 5.34922E-05 16 1.37740E-01 8.35049E-05 1.33441E-01 8.07920E-05 1.35200E-01 5.25372E-04 1.35705E-01 6.12931E-05 17 1.36799E-01 9.14332E-05 1.32632E-01 9.29170E-05 1.34526E-01 7.06048E-04 1.34934E-01 6.86394E-05 18 1.36144E-01 1.01309E-04 1.32211E-01 1.07420E-04 1.34842E-01 9.16465E-04 1.34412E-01 7.70717E-05 19 1.35603E-01 1.11864E-04 1.31777E-01 1.25589E-04 1.33889E-01 1.46962E-03 1.34026E-01 8.66862E-05 20 1.34617E-01 1.26909E-04 1.31439E-01 1.48908E-04 1.35004E-01 1.84202E-03 1.33384E-01 9.91017E-05 21 1.34279E-01 1.44949E-04 1.31002E-01 1.74224E-04 1.31416E-01 2.08701E-03 1.33065E-01 1.13690E-04 22 1.34039E-01 1.65986E-04 1.30519E-01 2.08641E-04 1.31951E-01 2.32509E-03 1.32784E-01 1.31990E-04 23 1.33200E-01 1.87216E-04 1.30444E-01 2.45913E-04 1.28802E-01 2.92200E-03 1.32275E-01 1.50907E-04 24 1.33013E-01 2.20804E-04 1.30239E-01 3.08586E-04 1.33300E-01 6.34024E-03 1.32093E-01 1.81048E-04 25 1.32884E-01 2.55171E-04 1.29589E-01 3.55376E-04 1.30094E-01 7.92940E-03 1.31870E-01 2.09346E-04 26 1.32223E-01 2.84591E-04 1.29890E-01 4.27746E-04 1.31313E-01 0.00000E+00 1.31553E-01 2.38389E-04 27 1.32304E-01 3.26987E-04 1.27976E-01 4.92481E-04 1.22727E-01 0.00000E+00 1.31092E-01 2.74971E-04 28 1.31503E-01 3.93201E-04 1.28626E-01 6.42677E-04 1.45833E-01 0.00000E+00 1.30743E-01 3.36794E-04 29 1.31714E-01 4.68205E-04 1.28163E-01 7.35345E-04 --- --- 1.30782E-01 3.97894E-04 30 1.32173E-01 5.42832E-04 1.28793E-01 8.55725E-04 --- --- 1.31361E-01 4.63188E-04 31 1.30690E-01 5.98854E-04 1.27278E-01 1.07095E-03 --- --- 1.29915E-01 5.24872E-04 32 1.32202E-01 7.19272E-04 1.30212E-01 1.40443E-03 --- --- 1.31708E-01 6.44378E-04 33 1.29779E-01 8.29554E-04 1.27643E-01 1.62455E-03 --- --- 1.29291E-01 7.40222E-04 34 1.33511E-01 1.06675E-03 1.28161E-01 2.09790E-03 --- --- 1.32318E-01 9.58871E-04 35 1.31356E-01 1.16167E-03 1.28994E-01 2.87861E-03 --- --- 1.30970E-01 1.07852E-03 36 1.32705E-01 1.43683E-03 1.25900E-01 1.70772E-03 --- --- 1.31192E-01 1.19698E-03 37 1.29662E-01 1.36475E-03 1.29206E-01 3.56337E-03 --- --- 1.29599E-01 1.26881E-03 38 1.32521E-01 1.95730E-03 1.28431E-01 2.07455E-03 --- --- 1.31598E-01 1.59383E-03 39 1.33405E-01 2.65171E-03 1.36223E-01 8.61604E-03 --- --- 1.33627E-01 2.50674E-03 40 1.31186E-01 2.41629E-03 1.24286E-01 5.93693E-03 --- --- 1.29254E-01 2.41761E-03 41 1.34637E-01 3.72790E-03 1.23765E-01 4.36288E-03 --- --- 1.32660E-01 3.24597E-03 42 1.32169E-01 2.82861E-03 1.20069E-01 7.60345E-03 --- --- 1.30233E-01 2.75261E-03 43 1.27296E-01 4.51388E-03 1.10256E-01 0.00000E+00 --- --- 1.25876E-01 4.35840E-03 44 1.27773E-01 4.52073E-03 --- --- --- --- 1.27773E-01 4.52073E-03 45 1.27919E-01 1.01179E-02 1.14796E-01 0.00000E+00 --- --- 1.23545E-01 7.29785E-03 46 1.29700E-01 4.57218E-03 --- --- --- --- 1.29700E-01 4.57218E-03 47 1.37675E-01 1.20065E-02 --- --- --- --- 1.37675E-01 1.20065E-02 48 --- --- 1.27660E-01 0.00000E+00 --- --- 1.27660E-01 0.00000E+00 49 --- --- --- --- --- --- --- --- 50 1.31495E-01 5.86725E-03 --- --- --- --- 1.31495E-01 5.86725E-03 Average 1.83709E-01 2.94185E-05 2.51847E-01 1.92824E-05 3.62166E-01 1.98733E-05 2.98525E-01 1.33265E-05 -------------------------------------------------------------------------------------------------------------------