=============================== MCDS Version 2.01 19-JAN-2006 =============================== 8.895 running time (min) 1141749760 seed 100000 number of cells RADIATION TYPE: 4He 3.2000E+00 Kinetic energy (MeV) >= 1.9882E+00 MeV 3.7264E+03 Rest mass energy (MeV) 4.1416E-02 Speed (beta=v/c) 2.1566E+03 (Zeff/beta)^2 <= 3200 DAMAGE FORMATION AND CLUSTERING: 39216 segment length, nseg (bp per cell per Gy) 1300 number of strand breaks, sigSb (per cell per Gy) 3900 number of base damages, sigBd (per cell per Gy) 3.0 base damage to strand break ratio, f 9 minimum distance between clusters, Nmin (bp) 10 maximum distance between two Sb to compose a DSB, Ndsb (bp) 0.0 fraction Bl/Bd DMSO SIMULATION: 5.0000E-01 fraction of non-scavengeable DNA damage 5.0000E-01 concentration at half-level (mol dm^-3) 0.0000E+00 DMSO concentration (mol dm^-3) % DAMAGE YIELD (See Nikjoo et al. 1997 Int.J.Radiat.Biol. 71, 467-483; Nikjoo et al. 2001 Radiat.Res. 156, 577-583) =================================================================================================================== 45.754 BD - one or more Bd (no Sb) 33.108 SSB - Sb (no auxilary damage) 7.803 SSB+ - two Sb on the same strand 3.386 2SSB - two or more Sb on opposite strands separated by at least 10 bp 4.545 DSB - two Sb on opposite strands with a separation <= 10 bp 2.915 DSB+ - DSB accompanied by one (or more) additional Sb within 10 bp separation 2.491 DSB++ - more than one DSB whether within the 10 bp separation or further apart 25.258 SSBc - fraction of complex damage (SSB+ and 2SSB) among SSBs 84.147 SSBcb - fraction of complex damage (SSB+ and 2SSB) among SSBs; base damage included 54.325 DSBc - fraction of complex damage (DSB+ and DSB++) among DSBs 93.328 DSBcb - fraction of complex damage (DSB+ and DSB++) among DSBs; base damage included =================================================================================================================== NUMBER OF CLUSTERS (per cell per Gy) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.02746E+02 3.03571E-02 3.08255E+02 5.09550E-02 4.11001E+02 5.79552E-02 2 9.70623E+00 9.72605E-03 1.19827E+02 3.30204E-02 1.66549E+02 3.84899E-02 2.96082E+02 5.08810E-02 3 1.63794E+01 1.24937E-02 1.06582E+02 3.14307E-02 8.96934E+01 2.85034E-02 2.12655E+02 4.37699E-02 4 1.86961E+01 1.33624E-02 8.58801E+01 2.85412E-02 4.83717E+01 2.10279E-02 1.52948E+02 3.73869E-02 5 1.81797E+01 1.31864E-02 6.56117E+01 2.49339E-02 2.60611E+01 1.56156E-02 1.09852E+02 3.16623E-02 6 1.62998E+01 1.25052E-02 4.86098E+01 2.13823E-02 1.40569E+01 1.15839E-02 7.89665E+01 2.67812E-02 7 1.39277E+01 1.15593E-02 3.52514E+01 1.82612E-02 7.56407E+00 8.54162E-03 5.67432E+01 2.27590E-02 8 1.14928E+01 1.05038E-02 2.51616E+01 1.53957E-02 4.06833E+00 6.28823E-03 4.07227E+01 1.92630E-02 9 9.30785E+00 9.46330E-03 1.78123E+01 1.30737E-02 2.19267E+00 4.64186E-03 2.93128E+01 1.64471E-02 10 7.37732E+00 8.44273E-03 1.24676E+01 1.09513E-02 1.17855E+00 3.41529E-03 2.10235E+01 1.40050E-02 11 5.76902E+00 7.46461E-03 8.69945E+00 9.16330E-03 6.39060E-01 2.52200E-03 1.51075E+01 1.18794E-02 12 4.47336E+00 6.58464E-03 6.02960E+00 7.64595E-03 3.41000E-01 1.84153E-03 1.08440E+01 1.01074E-02 13 3.44259E+00 5.78724E-03 4.18003E+00 6.37241E-03 1.82440E-01 1.34803E-03 7.80506E+00 8.60720E-03 14 2.62913E+00 5.06771E-03 2.87567E+00 5.29061E-03 9.84200E-02 9.88810E-04 5.60322E+00 7.30642E-03 15 1.99567E+00 4.43580E-03 1.98564E+00 4.42571E-03 5.38300E-02 7.33027E-04 4.03514E+00 6.27200E-03 16 1.50184E+00 3.84850E-03 1.36162E+00 3.66847E-03 2.85500E-02 5.34370E-04 2.89201E+00 5.31042E-03 17 1.12525E+00 3.33756E-03 9.31760E-01 3.02756E-03 1.64200E-02 4.03615E-04 2.07343E+00 4.49755E-03 18 8.44970E-01 2.89970E-03 6.36530E-01 2.51385E-03 8.29000E-03 2.88814E-04 1.48979E+00 3.82937E-03 19 6.29420E-01 2.49547E-03 4.39900E-01 2.08867E-03 4.38000E-03 2.09305E-04 1.07370E+00 3.24703E-03 20 4.63760E-01 2.13750E-03 3.03230E-01 1.73944E-03 2.26000E-03 1.50164E-04 7.69250E-01 2.75386E-03 21 3.44560E-01 1.85192E-03 2.04130E-01 1.42865E-03 1.19000E-03 1.09023E-04 5.49880E-01 2.33465E-03 22 2.56060E-01 1.59548E-03 1.38790E-01 1.17443E-03 6.80000E-04 8.24345E-05 3.95530E-01 1.97517E-03 23 1.90300E-01 1.38003E-03 9.73500E-02 9.85971E-04 4.20000E-04 6.47941E-05 2.88070E-01 1.69230E-03 24 1.39210E-01 1.18098E-03 6.59600E-02 8.12588E-04 1.90000E-04 4.35851E-05 2.05360E-01 1.42916E-03 25 1.01630E-01 1.00619E-03 4.50500E-02 6.71126E-04 1.10000E-04 3.31646E-05 1.46790E-01 1.21204E-03 26 7.52300E-02 8.65281E-04 3.03400E-02 5.49361E-04 7.00000E-05 2.64567E-05 1.05640E-01 1.02304E-03 27 5.42900E-02 7.36499E-04 2.17000E-02 4.64858E-04 1.00000E-05 1.00000E-05 7.60000E-02 8.69280E-04 28 3.95800E-02 6.29077E-04 1.43900E-02 3.77930E-04 --- --- 5.39700E-02 7.34968E-04 29 2.85100E-02 5.35327E-04 9.82000E-03 3.13108E-04 1.00000E-05 1.00000E-05 3.83400E-02 6.19439E-04 30 2.11100E-02 4.58744E-04 6.42000E-03 2.52564E-04 --- --- 2.75300E-02 5.24141E-04 31 1.54500E-02 3.91554E-04 4.75000E-03 2.17887E-04 --- --- 2.02000E-02 4.48020E-04 32 1.11300E-02 3.33260E-04 3.28000E-03 1.80811E-04 --- --- 1.44100E-02 3.78715E-04 33 8.03000E-03 2.82942E-04 2.16000E-03 1.46811E-04 --- --- 1.01900E-02 3.20098E-04 34 5.82000E-03 2.41789E-04 1.58000E-03 1.25599E-04 --- --- 7.40000E-03 2.72494E-04 35 4.39000E-03 2.10018E-04 9.10000E-04 9.53510E-05 --- --- 5.30000E-03 2.30477E-04 36 3.10000E-03 1.75796E-04 6.80000E-04 8.24345E-05 --- --- 3.78000E-03 1.94055E-04 37 2.33000E-03 1.53121E-04 4.00000E-04 6.32332E-05 --- --- 2.73000E-03 1.65607E-04 38 1.70000E-03 1.30274E-04 2.60000E-04 5.09838E-05 --- --- 1.96000E-03 1.39863E-04 39 1.15000E-03 1.07177E-04 2.80000E-04 5.29079E-05 --- --- 1.43000E-03 1.19498E-04 40 9.20000E-04 9.58730E-05 1.50000E-04 3.87271E-05 --- --- 1.07000E-03 1.03386E-04 41 6.80000E-04 8.24345E-05 7.00000E-05 2.64567E-05 --- --- 7.50000E-04 8.65705E-05 42 4.60000E-04 6.78080E-05 8.00000E-05 2.82833E-05 --- --- 5.40000E-04 7.34652E-05 43 4.20000E-04 6.47941E-05 6.00000E-05 2.44943E-05 --- --- 4.80000E-04 6.92657E-05 44 2.10000E-04 4.58212E-05 5.00000E-05 2.23602E-05 --- --- 2.60000E-04 5.09838E-05 45 1.40000E-04 3.74141E-05 4.00000E-05 1.99997E-05 --- --- 1.80000E-04 4.24228E-05 46 1.30000E-04 3.60533E-05 1.00000E-05 1.00000E-05 --- --- 1.40000E-04 3.74141E-05 47 9.00000E-05 2.99988E-05 2.00000E-05 1.41421E-05 --- --- 1.10000E-04 3.31646E-05 48 5.00000E-05 2.23602E-05 --- --- --- --- 5.00000E-05 2.23602E-05 49 1.00000E-04 3.16214E-05 --- --- --- --- 1.00000E-04 3.16214E-05 50 4.00000E-05 1.99997E-05 --- --- --- --- 4.00000E-05 1.99997E-05 Total 1.45549E+02 2.82746E-02 6.48042E+02 5.92962E-02 6.69368E+02 5.98201E-02 1.46296E+03 6.21626E-02 ------------------------------------------------------------------------------------------------------------------- NOTES: The damage yields are for an average human cell (genome length = 6E+09 base pairs). The category OTHER includes all classes of single and clustered damage sites that do not contain strand breaks (Sb). SEM - standard error of the mean. CLUSTER COMPOSITION (% Sb) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.00000E+02 0.00000E+00 0.00000E+00 0.00000E+00 2.49987E+01 6.49064E-03 2 1.00000E+02 0.00000E+00 5.36668E+01 3.78279E-03 0.00000E+00 0.00000E+00 2.49969E+01 5.30826E-03 3 7.18878E+01 9.80195E-03 3.88438E+01 3.96190E-03 0.00000E+00 0.00000E+00 2.50039E+01 5.09908E-03 4 5.83997E+01 9.92438E-03 3.18186E+01 4.22440E-03 0.00000E+00 0.00000E+00 2.50021E+01 5.19554E-03 5 5.06340E+01 1.00037E-02 2.78266E+01 4.63472E-03 0.00000E+00 0.00000E+00 2.49974E+01 5.55369E-03 6 4.56101E+01 1.03351E-02 2.52985E+01 5.12423E-03 0.00000E+00 0.00000E+00 2.49861E+01 6.04693E-03 7 4.21269E+01 1.08651E-02 2.36099E+01 5.82454E-03 0.00000E+00 0.00000E+00 2.50043E+01 6.67586E-03 8 3.95295E+01 1.16317E-02 2.24133E+01 6.63993E-03 0.00000E+00 0.00000E+00 2.50033E+01 7.40981E-03 9 3.75480E+01 1.26397E-02 2.15463E+01 7.72446E-03 0.00000E+00 0.00000E+00 2.50129E+01 8.36058E-03 10 3.59771E+01 1.39740E-02 2.08712E+01 9.09308E-03 0.00000E+00 0.00000E+00 2.50028E+01 9.48652E-03 11 3.46957E+01 1.57979E-02 2.03976E+01 1.08817E-02 0.00000E+00 0.00000E+00 2.49897E+01 1.08448E-02 12 3.36475E+01 1.78190E-02 2.00302E+01 1.31881E-02 0.00000E+00 0.00000E+00 2.50140E+01 1.24943E-02 13 3.27384E+01 2.00116E-02 1.97289E+01 1.58570E-02 0.00000E+00 0.00000E+00 2.49957E+01 1.45576E-02 14 3.19986E+01 2.23011E-02 1.95231E+01 1.88528E-02 0.00000E+00 0.00000E+00 2.50397E+01 1.72200E-02 15 3.13351E+01 2.46452E-02 1.92762E+01 2.17527E-02 0.00000E+00 0.00000E+00 2.49931E+01 2.01856E-02 16 3.08008E+01 2.73767E-02 1.91848E+01 2.51762E-02 0.00000E+00 0.00000E+00 2.50364E+01 2.34797E-02 17 3.02641E+01 3.02903E-02 1.90494E+01 2.88777E-02 0.00000E+00 0.00000E+00 2.49816E+01 2.67052E-02 18 2.98172E+01 3.32634E-02 1.89976E+01 3.34909E-02 0.00000E+00 0.00000E+00 2.50292E+01 2.98022E-02 19 2.93686E+01 3.70708E-02 1.88966E+01 3.86657E-02 0.00000E+00 0.00000E+00 2.49613E+01 3.33025E-02 20 2.89949E+01 4.15037E-02 1.87342E+01 4.45167E-02 0.00000E+00 0.00000E+00 2.48785E+01 3.75783E-02 21 2.87920E+01 4.73372E-02 1.88824E+01 5.27305E-02 0.00000E+00 0.00000E+00 2.50624E+01 4.27792E-02 22 2.85375E+01 5.30923E-02 1.86271E+01 6.16697E-02 0.00000E+00 0.00000E+00 2.50157E+01 4.86378E-02 23 2.82017E+01 6.07271E-02 1.84949E+01 7.20943E-02 0.00000E+00 0.00000E+00 2.48736E+01 5.54220E-02 24 2.80356E+01 6.85349E-02 1.87935E+01 8.70185E-02 0.00000E+00 0.00000E+00 2.50244E+01 6.29456E-02 25 2.79448E+01 7.78269E-02 1.85645E+01 1.03580E-01 0.00000E+00 0.00000E+00 2.50567E+01 7.30453E-02 26 2.75835E+01 8.87879E-02 1.85106E+01 1.18269E-01 0.00000E+00 0.00000E+00 2.49539E+01 8.28534E-02 27 2.74872E+01 1.04083E-01 1.83739E+01 1.35553E-01 0.00000E+00 0.00000E+00 2.48695E+01 9.66854E-02 28 2.73374E+01 1.19281E-01 1.83179E+01 1.73267E-01 --- --- 2.49400E+01 1.13260E-01 29 2.71439E+01 1.37258E-01 1.85493E+01 1.99047E-01 0.00000E+00 0.00000E+00 2.49279E+01 1.29735E-01 30 2.68252E+01 1.57798E-01 1.83645E+01 2.48681E-01 --- --- 2.48559E+01 1.50660E-01 31 2.71311E+01 1.85296E-01 1.86471E+01 2.81322E-01 --- --- 2.51295E+01 1.76062E-01 32 2.67092E+01 2.00230E-01 1.89310E+01 3.42968E-01 --- --- 2.49314E+01 1.93510E-01 33 2.65766E+01 2.40186E-01 1.83221E+01 4.27334E-01 --- --- 2.48479E+01 2.35080E-01 34 2.66509E+01 2.88324E-01 1.82800E+01 4.97129E-01 --- --- 2.48541E+01 2.80719E-01 35 2.68258E+01 3.27270E-01 1.87755E+01 6.53366E-01 --- --- 2.54383E+01 3.21629E-01 36 2.64606E+01 3.80070E-01 1.78105E+01 7.27462E-01 --- --- 2.49045E+01 3.78548E-01 37 2.67766E+01 4.57743E-01 1.83784E+01 9.54078E-01 --- --- 2.55415E+01 4.51936E-01 38 2.65789E+01 5.56177E-01 1.80162E+01 1.08936E+00 --- --- 2.54431E+01 5.44030E-01 39 2.61538E+01 6.05222E-01 1.78571E+01 8.28686E-01 --- --- 2.45293E+01 5.81709E-01 40 2.63587E+01 6.42421E-01 1.78333E+01 1.35547E+00 --- --- 2.51636E+01 6.49076E-01 41 2.55022E+01 7.05198E-01 1.84669E+01 1.58399E+00 --- --- 2.48455E+01 6.95575E-01 42 2.62422E+01 1.01067E+00 1.72619E+01 2.83688E+00 --- --- 2.49118E+01 1.04321E+00 43 2.45847E+01 8.86611E-01 1.35659E+01 1.26192E+00 --- --- 2.32074E+01 9.50650E-01 44 2.77056E+01 1.49296E+00 1.86364E+01 2.31774E+00 --- --- 2.59615E+01 1.45484E+00 45 2.90476E+01 2.25211E+00 1.77778E+01 1.81444E+00 --- --- 2.65432E+01 2.10644E+00 46 2.85953E+01 1.70262E+00 1.08696E+01 0.00000E+00 --- --- 2.73292E+01 2.02185E+00 47 2.83688E+01 2.62986E+00 8.51064E+00 0.00000E+00 --- --- 2.47582E+01 3.22386E+00 48 2.41667E+01 1.69251E+00 --- --- --- --- 2.41667E+01 1.69251E+00 49 2.57143E+01 1.46535E+00 --- --- --- --- 2.57143E+01 1.46535E+00 50 2.05000E+01 2.06155E+00 --- --- --- --- 2.05000E+01 2.06155E+00 Average 5.04492E+01 5.31122E-03 4.51041E+01 3.03814E-03 0.00000E+00 0.00000E+00 2.49995E+01 1.66460E-03 ------------------------------------------------------------------------------------------------------------------- NOTES: (% Sb) is the percentage of lesions that are strand breaks. The number of Sb is ((% Sb)/100)*(# lesions). The number of Bd is (1-(% Sb)/100)*(# lesions). CLUSTER LENGTH (base pairs) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.00000E+00 0.00000E+00 1.00000E+00 0.00000E+00 1.00000E+00 0.00000E+00 2 4.72574E+00 2.87004E-03 4.92035E+00 7.43164E-04 4.90567E+00 6.30537E-04 4.90569E+00 4.71547E-04 3 8.28932E+00 2.82799E-03 8.91366E+00 1.11925E-03 8.83202E+00 1.21211E-03 8.83118E+00 7.80760E-04 4 1.19669E+01 3.25686E-03 1.29234E+01 1.52286E-03 1.27550E+01 2.03901E-03 1.27531E+01 1.13365E-03 5 1.57617E+01 3.85699E-03 1.69284E+01 2.00702E-03 1.66777E+01 3.23942E-03 1.66758E+01 1.54691E-03 6 1.96376E+01 4.56290E-03 2.09232E+01 2.61080E-03 2.05986E+01 5.02876E-03 2.05993E+01 2.04194E-03 7 2.35337E+01 5.49446E-03 2.49144E+01 3.37454E-03 2.45290E+01 7.86337E-03 2.45247E+01 2.65397E-03 8 2.74534E+01 6.59173E-03 2.89065E+01 4.34832E-03 2.84378E+01 1.22666E-02 2.84499E+01 3.38079E-03 9 3.13963E+01 7.98612E-03 3.28899E+01 5.57271E-03 3.23681E+01 1.79615E-02 3.23765E+01 4.30182E-03 10 3.53180E+01 9.71447E-03 3.68567E+01 7.18112E-03 3.62691E+01 2.49642E-02 3.62859E+01 5.45432E-03 11 3.92361E+01 1.18954E-02 4.08660E+01 9.30808E-03 4.02556E+01 3.43107E-02 4.02219E+01 6.83273E-03 12 4.31859E+01 1.45382E-02 4.48258E+01 1.21652E-02 4.41868E+01 4.77248E-02 4.41305E+01 8.62491E-03 13 4.71177E+01 1.74638E-02 4.88164E+01 1.57430E-02 4.81487E+01 6.68212E-02 4.80491E+01 1.08662E-02 14 5.10988E+01 2.09865E-02 5.28139E+01 1.99937E-02 5.20592E+01 9.42484E-02 5.19919E+01 1.38252E-02 15 5.50326E+01 2.45639E-02 5.68031E+01 2.47645E-02 5.60641E+01 1.31931E-01 5.59036E+01 1.74466E-02 16 5.89621E+01 2.88870E-02 6.07820E+01 3.01122E-02 5.99206E+01 1.84701E-01 5.98233E+01 2.15313E-02 17 6.29477E+01 3.39620E-02 6.47845E+01 3.64979E-02 6.33489E+01 2.46384E-01 6.37925E+01 2.60196E-02 18 6.68359E+01 3.92442E-02 6.87502E+01 4.46722E-02 6.77987E+01 3.69001E-01 6.76387E+01 3.09239E-02 19 7.08192E+01 4.59136E-02 7.28096E+01 5.38733E-02 7.16522E+01 5.30528E-01 7.16440E+01 3.65458E-02 20 7.47305E+01 5.46833E-02 7.68114E+01 6.63080E-02 7.57832E+01 6.67969E-01 7.55483E+01 4.37720E-02 21 7.87415E+01 6.37446E-02 8.07612E+01 8.10085E-02 8.13277E+01 1.03899E+00 7.94776E+01 5.14860E-02 22 8.27357E+01 7.61536E-02 8.46910E+01 1.01154E-01 8.61765E+01 1.48876E+00 8.34291E+01 6.22226E-02 23 8.65023E+01 8.87722E-02 8.86805E+01 1.22160E-01 8.89286E+01 2.30598E+00 8.72491E+01 7.30845E-02 24 9.05173E+01 1.05769E-01 9.28100E+01 1.50959E-01 8.84737E+01 2.86374E+00 9.12759E+01 8.79009E-02 25 9.45012E+01 1.26086E-01 9.68912E+01 1.87343E-01 9.47273E+01 3.14813E+00 9.52269E+01 1.05706E-01 26 9.85093E+01 1.47129E-01 1.00574E+02 2.34355E-01 9.45714E+01 3.44243E+00 9.91144E+01 1.25623E-01 27 1.02619E+02 1.78393E-01 1.04740E+02 2.79322E-01 1.07000E+02 0.00000E+00 1.03227E+02 1.51275E-01 28 1.06472E+02 2.13405E-01 1.09086E+02 3.46598E-01 --- --- 1.07190E+02 1.82923E-01 29 1.09830E+02 2.54717E-01 1.13536E+02 4.26326E-01 1.26000E+02 0.00000E+00 1.10801E+02 2.20395E-01 30 1.14613E+02 2.90762E-01 1.16022E+02 5.52584E-01 --- --- 1.14955E+02 2.58396E-01 31 1.18827E+02 3.56372E-01 1.21123E+02 6.45938E-01 --- --- 1.19347E+02 3.12191E-01 32 1.21732E+02 4.29161E-01 1.24558E+02 7.84448E-01 --- --- 1.22373E+02 3.78143E-01 33 1.25724E+02 5.03902E-01 1.30384E+02 9.75862E-01 --- --- 1.26748E+02 4.51926E-01 34 1.28711E+02 5.93114E-01 1.33019E+02 1.17392E+00 --- --- 1.29635E+02 5.33043E-01 35 1.33638E+02 6.95744E-01 1.31341E+02 1.40549E+00 --- --- 1.33242E+02 6.25320E-01 36 1.37158E+02 9.09229E-01 1.39485E+02 2.12406E+00 --- --- 1.37577E+02 8.37884E-01 37 1.42705E+02 1.06951E+00 1.41275E+02 2.08043E+00 --- --- 1.42494E+02 9.61340E-01 38 1.48035E+02 1.19719E+00 1.47269E+02 3.01971E+00 --- --- 1.47934E+02 1.11032E+00 39 1.51383E+02 1.42397E+00 1.53750E+02 3.20409E+00 --- --- 1.51846E+02 1.30290E+00 40 1.54609E+02 1.69101E+00 1.60267E+02 4.66136E+00 --- --- 1.55402E+02 1.59670E+00 41 1.58985E+02 2.10026E+00 1.59714E+02 6.03843E+00 --- --- 1.59053E+02 1.97424E+00 42 1.65717E+02 1.94307E+00 1.72125E+02 6.16278E+00 --- --- 1.66667E+02 1.88988E+00 43 1.68833E+02 2.43854E+00 1.67167E+02 7.43154E+00 --- --- 1.68625E+02 2.29778E+00 44 1.68905E+02 3.49210E+00 1.78800E+02 6.07783E+00 --- --- 1.70808E+02 3.10237E+00 45 1.83000E+02 4.56335E+00 1.56750E+02 8.70225E+00 --- --- 1.77167E+02 4.72875E+00 46 1.84769E+02 5.67061E+00 1.65000E+02 0.00000E+00 --- --- 1.83357E+02 5.43655E+00 47 1.91778E+02 4.48695E+00 1.73000E+02 5.00000E+00 --- --- 1.88364E+02 4.34485E+00 48 1.87600E+02 6.40000E+00 --- --- --- --- 1.87600E+02 6.40000E+00 49 1.88700E+02 6.96826E+00 --- --- --- --- 1.88700E+02 6.96826E+00 50 2.06750E+02 4.60751E+00 --- --- --- --- 2.06750E+02 4.60751E+00 Average 2.36905E+01 4.28201E-03 1.37765E+01 1.39944E-03 5.58209E+00 7.77782E-04 1.10132E+01 7.82854E-04 ------------------------------------------------------------------------------------------------------------------- NUMBER OF LESIONS DIVIDED BY TWICE THE CLUSTER LENGTH (lesions per nucleotide) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 5.00000E-01 0.00000E+00 5.00000E-01 0.00000E+00 5.00000E-01 0.00000E+00 2 3.25002E-01 2.72832E-04 2.89284E-01 5.91684E-05 2.91935E-01 5.09878E-05 2.91944E-01 3.81420E-05 3 2.26719E-01 1.04458E-04 2.09390E-01 3.67332E-05 2.11627E-01 4.03715E-05 2.11668E-01 2.60807E-05 4 1.95635E-01 6.94575E-05 1.79646E-01 2.88032E-05 1.82441E-01 3.92896E-05 1.82488E-01 2.19355E-05 5 1.78887E-01 5.46919E-05 1.64873E-01 2.50975E-05 1.67884E-01 4.16602E-05 1.67908E-01 1.99047E-05 6 1.68129E-01 4.74746E-05 1.56387E-01 2.39895E-05 1.59379E-01 4.77550E-05 1.59350E-01 1.94200E-05 7 1.60967E-01 4.45387E-05 1.50888E-01 2.42313E-05 1.53737E-01 5.86034E-05 1.53738E-01 1.97705E-05 8 1.55767E-01 4.33303E-05 1.47056E-01 2.55414E-05 1.49882E-01 7.49905E-05 1.49796E-01 2.06693E-05 9 1.51867E-01 4.39157E-05 1.44272E-01 2.77851E-05 1.46934E-01 9.26866E-05 1.46883E-01 2.22422E-05 10 1.49006E-01 4.61072E-05 1.42154E-01 3.09552E-05 1.44789E-01 1.11811E-04 1.44702E-01 2.44181E-05 11 1.46734E-01 4.93553E-05 1.40373E-01 3.53980E-05 1.42735E-01 1.34685E-04 1.42887E-01 2.69178E-05 12 1.44795E-01 5.36823E-05 1.39075E-01 4.13839E-05 1.41246E-01 1.66295E-04 1.41497E-01 3.03903E-05 13 1.43194E-01 5.78265E-05 1.37883E-01 4.82844E-05 1.39987E-01 2.13641E-04 1.40289E-01 3.45131E-05 14 1.41803E-01 6.31968E-05 1.36866E-01 5.58996E-05 1.39056E-01 2.73554E-04 1.39221E-01 4.00530E-05 15 1.40663E-01 6.76820E-05 1.36060E-01 6.38408E-05 1.37996E-01 3.49491E-04 1.38400E-01 4.65255E-05 16 1.39755E-01 7.33771E-05 1.35328E-01 7.17856E-05 1.37353E-01 4.53874E-04 1.37660E-01 5.30922E-05 17 1.38845E-01 7.97446E-05 1.34657E-01 8.08388E-05 1.37740E-01 5.73838E-04 1.36914E-01 5.93907E-05 18 1.38179E-01 8.62927E-05 1.34156E-01 9.22817E-05 1.36145E-01 7.75080E-04 1.36486E-01 6.62481E-05 19 1.37442E-01 9.43659E-05 1.33493E-01 1.04425E-04 1.35954E-01 1.06712E-03 1.35811E-01 7.32851E-05 20 1.36983E-01 1.06018E-04 1.33077E-01 1.21254E-04 1.34320E-01 1.21165E-03 1.35448E-01 8.29440E-05 21 1.36282E-01 1.16156E-04 1.32684E-01 1.39542E-04 1.31877E-01 1.88933E-03 1.34966E-01 9.20069E-05 22 1.35828E-01 1.32113E-04 1.32484E-01 1.65632E-04 1.30239E-01 2.28267E-03 1.34646E-01 1.05879E-04 23 1.35611E-01 1.45860E-04 1.32125E-01 1.90241E-04 1.32942E-01 3.49763E-03 1.34419E-01 1.18077E-04 24 1.35111E-01 1.64521E-04 1.31607E-01 2.22829E-04 1.38437E-01 4.87877E-03 1.33959E-01 1.34554E-04 25 1.34704E-01 1.87287E-04 1.31238E-01 2.63663E-04 1.33608E-01 5.02919E-03 1.33649E-01 1.54662E-04 26 1.34226E-01 2.08054E-04 1.31431E-01 3.14349E-04 1.38539E-01 4.94934E-03 1.33408E-01 1.74817E-04 27 1.33749E-01 2.39906E-04 1.30945E-01 3.62630E-04 1.26168E-01 0.00000E+00 1.32945E-01 2.01421E-04 28 1.33636E-01 2.77899E-04 1.30247E-01 4.25109E-04 --- --- 1.32706E-01 2.34605E-04 29 1.34111E-01 3.23405E-04 1.29532E-01 5.02047E-04 1.15079E-01 0.00000E+00 1.32909E-01 2.74860E-04 30 1.32692E-01 3.45360E-04 1.31229E-01 6.46418E-04 --- --- 1.32338E-01 3.05693E-04 31 1.32309E-01 4.10491E-04 1.29719E-01 7.03229E-04 --- --- 1.31714E-01 3.54692E-04 32 1.33299E-01 4.85586E-04 1.30244E-01 8.81831E-04 --- --- 1.32609E-01 4.27109E-04 33 1.32974E-01 5.46878E-04 1.28166E-01 1.01937E-03 --- --- 1.31912E-01 4.85958E-04 34 1.33723E-01 6.24796E-04 1.29424E-01 1.18237E-03 --- --- 1.32800E-01 5.55723E-04 35 1.32564E-01 7.18346E-04 1.34608E-01 1.43430E-03 --- --- 1.32916E-01 6.44220E-04 36 1.33088E-01 9.17476E-04 1.31141E-01 2.08230E-03 --- --- 1.32737E-01 8.40193E-04 37 1.31424E-01 1.03801E-03 1.32122E-01 2.05085E-03 --- --- 1.31526E-01 9.34132E-04 38 1.29810E-01 1.08080E-03 1.30331E-01 2.58365E-03 --- --- 1.29879E-01 9.95871E-04 39 1.30168E-01 1.27759E-03 1.28329E-01 2.68281E-03 --- --- 1.29808E-01 1.15132E-03 40 1.30910E-01 1.58200E-03 1.26384E-01 3.95644E-03 --- --- 1.30276E-01 1.46986E-03 41 1.30442E-01 1.71525E-03 1.29467E-01 4.94770E-03 --- --- 1.30351E-01 1.61292E-03 42 1.27520E-01 1.52029E-03 1.23158E-01 4.61912E-03 --- --- 1.26874E-01 1.46099E-03 43 1.28472E-01 1.91574E-03 1.29889E-01 5.76031E-03 --- --- 1.28649E-01 1.80202E-03 44 1.31398E-01 2.78931E-03 1.23616E-01 4.22553E-03 --- --- 1.29902E-01 2.43986E-03 45 1.24027E-01 3.34288E-03 1.44910E-01 8.25591E-03 --- --- 1.28668E-01 3.70855E-03 46 1.25814E-01 3.64444E-03 1.39394E-01 0.00000E+00 --- --- 1.26784E-01 3.51076E-03 47 1.23063E-01 2.81489E-03 1.35952E-01 3.92924E-03 --- --- 1.25407E-01 2.81747E-03 48 1.28539E-01 4.46107E-03 --- --- --- --- 1.28539E-01 4.46107E-03 49 1.31399E-01 4.75404E-03 --- --- --- --- 1.31399E-01 4.75404E-03 50 1.21093E-01 2.60974E-03 --- --- --- --- 1.21093E-01 2.60974E-03 Average 1.82139E-01 2.75823E-05 2.46022E-01 1.96333E-05 3.57967E-01 2.13007E-05 2.90885E-01 1.38428E-05 -------------------------------------------------------------------------------------------------------------------