=============================== MCDS Version 3.00B 15-JUL-2011 =============================== 5.382 running time (min) 1.0000E+00 DNA content (Gbp) 5.0000E+00 Dia. of cell nucleus (um) 50000 number of cells (nocs) 987654321 random number seed MXRF TABLE: Particle types and properties of the (input) mixed radiation field. The hypoxia reduction factor (HRF) for DSB induction is estimated as [1/(1-pcr)]^2, where pcr = the probability a lesion undergoes chemical repair for the specified (input) oxygen concentration compared to fully aerobic (100% O2) conditions. The frequency-mean specific energy (zf) is for a spherical target representative of the cell nucleus. Radiative losses by the primary charged particle are assumed non-local and do not not contribute to specific energy or the dose per unit fluence (DPUF). The reported stopping power is at the point of entry into the cell nucleus (pO2 = 100.000%). =================================================================================================================== Normed -- Kinetic Energy -- Stopping Power (keV/um) CSDA Dosimetry (Gy) HRF Ion wt (MeV) (MeV/A) zeb Coll+Nuc Radiat Total Range (cm) DPUF zf DSB =================================================================================================================== e- 3.44E-03 3.315E-03 0.000E+00 7.782E+01 5.03E+00 3.54E-04 5.030E+00 4.180E-05 1.383E-02 7.04E-05 1.005 e- 4.06E-03 9.945E-03 0.000E+00 2.644E+01 2.29E+00 4.02E-04 2.287E+00 2.551E-04 2.196E+00 1.12E-02 1.005 e- 6.12E-03 1.657E-02 0.000E+00 1.617E+01 1.55E+00 4.05E-04 1.548E+00 6.153E-04 7.552E+00 3.85E-02 1.005 e- 7.68E-03 2.320E-02 0.000E+00 1.177E+01 1.19E+00 4.03E-04 1.195E+00 1.108E-03 3.490E+00 1.78E-02 1.005 e- 7.86E-03 2.984E-02 0.000E+00 9.321E+00 9.85E-01 4.01E-04 9.857E-01 1.722E-03 2.396E+00 1.22E-02 1.005 e- 1.00E-02 3.646E-02 0.000E+00 7.765E+00 8.46E-01 3.99E-04 8.466E-01 2.450E-03 1.864E+00 9.50E-03 1.005 e- 1.07E-02 4.310E-02 0.000E+00 6.689E+00 7.47E-01 3.98E-04 7.472E-01 3.286E-03 1.546E+00 7.87E-03 1.005 e- 1.22E-02 4.972E-02 0.000E+00 5.900E+00 6.72E-01 3.97E-04 6.724E-01 4.223E-03 1.332E+00 6.78E-03 1.005 e- 1.24E-02 5.636E-02 0.000E+00 5.297E+00 6.14E-01 3.97E-04 6.142E-01 5.256E-03 1.179E+00 6.00E-03 1.005 e- 1.27E-02 6.298E-02 0.000E+00 4.821E+00 5.67E-01 3.98E-04 5.674E-01 6.381E-03 1.063E+00 5.41E-03 1.005 e- 1.38E-02 6.961E-02 0.000E+00 4.436E+00 5.29E-01 3.99E-04 5.291E-01 7.592E-03 9.723E-01 4.95E-03 1.005 e- 1.39E-02 7.624E-02 0.000E+00 4.118E+00 4.97E-01 4.01E-04 4.970E-01 8.886E-03 8.994E-01 4.58E-03 1.005 e- 1.43E-02 8.288E-02 0.000E+00 3.852E+00 4.69E-01 4.03E-04 4.699E-01 1.026E-02 8.394E-01 4.28E-03 1.005 e- 1.41E-02 8.951E-02 0.000E+00 3.625E+00 4.46E-01 4.05E-04 4.465E-01 1.171E-02 7.892E-01 4.02E-03 1.005 e- 1.44E-02 9.613E-02 0.000E+00 3.429E+00 4.26E-01 4.08E-04 4.263E-01 1.323E-02 7.466E-01 3.80E-03 1.005 e- 1.35E-02 1.028E-01 0.000E+00 3.259E+00 4.08E-01 4.11E-04 4.085E-01 1.482E-02 7.099E-01 3.62E-03 1.005 e- 1.42E-02 1.094E-01 0.000E+00 3.110E+00 3.92E-01 4.14E-04 3.929E-01 1.647E-02 6.780E-01 3.45E-03 1.005 e- 1.36E-02 1.160E-01 0.000E+00 2.978E+00 3.78E-01 4.17E-04 3.789E-01 1.819E-02 6.501E-01 3.31E-03 1.005 e- 1.27E-02 1.227E-01 0.000E+00 2.860E+00 3.66E-01 4.21E-04 3.664E-01 1.997E-02 6.254E-01 3.19E-03 1.005 e- 1.26E-02 1.293E-01 0.000E+00 2.754E+00 3.55E-01 4.24E-04 3.552E-01 2.181E-02 6.034E-01 3.07E-03 1.005 e- 1.29E-02 1.359E-01 0.000E+00 2.659E+00 3.45E-01 4.28E-04 3.450E-01 2.370E-02 5.837E-01 2.97E-03 1.005 e- 1.37E-02 1.426E-01 0.000E+00 2.573E+00 3.35E-01 4.32E-04 3.358E-01 2.565E-02 5.659E-01 2.88E-03 1.005 e- 1.31E-02 1.492E-01 0.000E+00 2.495E+00 3.27E-01 4.37E-04 3.274E-01 2.765E-02 5.498E-01 2.80E-03 1.005 e- 1.45E-02 1.558E-01 0.000E+00 2.423E+00 3.19E-01 4.41E-04 3.196E-01 2.970E-02 5.352E-01 2.73E-03 1.005 e- 1.34E-02 1.624E-01 0.000E+00 2.357E+00 3.12E-01 4.45E-04 3.125E-01 3.180E-02 5.219E-01 2.66E-03 1.005 e- 1.29E-02 1.691E-01 0.000E+00 2.297E+00 3.06E-01 4.50E-04 3.060E-01 3.394E-02 5.096E-01 2.60E-03 1.005 e- 1.35E-02 1.757E-01 0.000E+00 2.241E+00 2.99E-01 4.54E-04 2.999E-01 3.613E-02 4.983E-01 2.54E-03 1.005 e- 1.22E-02 1.823E-01 0.000E+00 2.189E+00 2.94E-01 4.59E-04 2.943E-01 3.837E-02 4.880E-01 2.49E-03 1.005 e- 1.22E-02 1.890E-01 0.000E+00 2.141E+00 2.89E-01 4.64E-04 2.891E-01 4.064E-02 4.783E-01 2.44E-03 1.005 e- 1.30E-02 1.956E-01 0.000E+00 2.096E+00 2.84E-01 4.69E-04 2.842E-01 4.295E-02 4.694E-01 2.39E-03 1.005 e- 1.35E-02 2.022E-01 0.000E+00 2.055E+00 2.79E-01 4.74E-04 2.796E-01 4.530E-02 4.611E-01 2.35E-03 1.005 e- 1.24E-02 2.089E-01 0.000E+00 2.016E+00 2.75E-01 4.79E-04 2.754E-01 4.769E-02 4.534E-01 2.31E-03 1.005 e- 1.13E-02 2.155E-01 0.000E+00 1.979E+00 2.71E-01 4.84E-04 2.714E-01 5.012E-02 4.462E-01 2.27E-03 1.005 e- 1.30E-02 2.221E-01 0.000E+00 1.945E+00 2.67E-01 4.89E-04 2.677E-01 5.258E-02 4.394E-01 2.24E-03 1.005 e- 1.23E-02 2.287E-01 0.000E+00 1.913E+00 2.64E-01 4.95E-04 2.641E-01 5.507E-02 4.331E-01 2.21E-03 1.005 e- 1.23E-02 2.354E-01 0.000E+00 1.882E+00 2.60E-01 5.00E-04 2.608E-01 5.760E-02 4.271E-01 2.18E-03 1.005 e- 1.28E-02 2.420E-01 0.000E+00 1.854E+00 2.57E-01 5.06E-04 2.577E-01 6.016E-02 4.215E-01 2.15E-03 1.005 e- 1.27E-02 2.486E-01 0.000E+00 1.827E+00 2.54E-01 5.11E-04 2.547E-01 6.274E-02 4.162E-01 2.12E-03 1.005 e- 1.23E-02 2.553E-01 0.000E+00 1.801E+00 2.51E-01 5.17E-04 2.519E-01 6.536E-02 4.112E-01 2.09E-03 1.005 e- 1.23E-02 2.619E-01 0.000E+00 1.777E+00 2.49E-01 5.22E-04 2.493E-01 6.801E-02 4.065E-01 2.07E-03 1.005 e- 1.20E-02 2.685E-01 0.000E+00 1.754E+00 2.46E-01 5.28E-04 2.467E-01 7.068E-02 4.021E-01 2.05E-03 1.005 e- 1.21E-02 2.752E-01 0.000E+00 1.732E+00 2.44E-01 5.34E-04 2.444E-01 7.338E-02 3.978E-01 2.03E-03 1.005 e- 1.26E-02 2.818E-01 0.000E+00 1.711E+00 2.42E-01 5.39E-04 2.421E-01 7.611E-02 3.938E-01 2.01E-03 1.005 e- 1.22E-02 2.884E-01 0.000E+00 1.691E+00 2.39E-01 5.45E-04 2.399E-01 7.886E-02 3.900E-01 1.99E-03 1.005 e- 1.29E-02 2.950E-01 0.000E+00 1.672E+00 2.37E-01 5.51E-04 2.379E-01 8.163E-02 3.864E-01 1.97E-03 1.005 e- 1.28E-02 3.017E-01 0.000E+00 1.654E+00 2.35E-01 5.57E-04 2.359E-01 8.443E-02 3.829E-01 1.95E-03 1.005 e- 1.21E-02 3.083E-01 0.000E+00 1.637E+00 2.33E-01 5.63E-04 2.340E-01 8.725E-02 3.797E-01 1.93E-03 1.005 e- 1.24E-02 3.149E-01 0.000E+00 1.620E+00 2.32E-01 5.69E-04 2.323E-01 9.010E-02 3.765E-01 1.92E-03 1.005 e- 1.24E-02 3.216E-01 0.000E+00 1.604E+00 2.30E-01 5.75E-04 2.305E-01 9.296E-02 3.735E-01 1.90E-03 1.005 e- 1.32E-02 3.282E-01 0.000E+00 1.589E+00 2.28E-01 5.81E-04 2.289E-01 9.585E-02 3.707E-01 1.89E-03 1.005 e- 1.17E-02 3.348E-01 0.000E+00 1.575E+00 2.27E-01 5.88E-04 2.274E-01 9.876E-02 3.680E-01 1.87E-03 1.005 e- 1.32E-02 3.414E-01 0.000E+00 1.561E+00 2.25E-01 5.94E-04 2.259E-01 1.017E-01 3.654E-01 1.86E-03 1.005 e- 1.33E-02 3.481E-01 0.000E+00 1.548E+00 2.24E-01 6.00E-04 2.244E-01 1.046E-01 3.629E-01 1.85E-03 1.005 e- 1.39E-02 3.547E-01 0.000E+00 1.535E+00 2.22E-01 6.06E-04 2.230E-01 1.076E-01 3.605E-01 1.84E-03 1.005 e- 1.36E-02 3.613E-01 0.000E+00 1.522E+00 2.21E-01 6.13E-04 2.217E-01 1.106E-01 3.582E-01 1.82E-03 1.005 e- 1.37E-02 3.680E-01 0.000E+00 1.511E+00 2.20E-01 6.19E-04 2.205E-01 1.136E-01 3.560E-01 1.81E-03 1.005 e- 1.35E-02 3.746E-01 0.000E+00 1.499E+00 2.19E-01 6.25E-04 2.192E-01 1.166E-01 3.539E-01 1.80E-03 1.005 e- 1.51E-02 3.812E-01 0.000E+00 1.488E+00 2.17E-01 6.32E-04 2.181E-01 1.196E-01 3.518E-01 1.79E-03 1.005 e- 1.56E-02 3.879E-01 0.000E+00 1.478E+00 2.16E-01 6.38E-04 2.169E-01 1.227E-01 3.499E-01 1.78E-03 1.005 e- 1.64E-02 3.945E-01 0.000E+00 1.467E+00 2.15E-01 6.45E-04 2.159E-01 1.257E-01 3.480E-01 1.77E-03 1.005 e- 1.66E-02 4.011E-01 0.000E+00 1.457E+00 2.14E-01 6.51E-04 2.148E-01 1.288E-01 3.462E-01 1.76E-03 1.005 e- 1.70E-02 4.078E-01 0.000E+00 1.448E+00 2.13E-01 6.58E-04 2.138E-01 1.319E-01 3.445E-01 1.75E-03 1.005 e- 1.86E-02 4.144E-01 0.000E+00 1.439E+00 2.12E-01 6.64E-04 2.129E-01 1.350E-01 3.428E-01 1.75E-03 1.005 e- 1.71E-02 4.210E-01 0.000E+00 1.430E+00 2.11E-01 6.71E-04 2.119E-01 1.381E-01 3.412E-01 1.74E-03 1.005 e- 1.90E-02 4.276E-01 0.000E+00 1.421E+00 2.10E-01 6.78E-04 2.110E-01 1.413E-01 3.396E-01 1.73E-03 1.005 e- 2.12E-02 4.343E-01 0.000E+00 1.413E+00 2.09E-01 6.84E-04 2.102E-01 1.444E-01 3.381E-01 1.72E-03 1.005 e- 2.08E-02 4.409E-01 0.000E+00 1.405E+00 2.09E-01 6.91E-04 2.093E-01 1.476E-01 3.367E-01 1.71E-03 1.005 e- 2.25E-02 4.475E-01 0.000E+00 1.397E+00 2.08E-01 6.98E-04 2.085E-01 1.508E-01 3.353E-01 1.71E-03 1.005 e- 2.52E-02 4.542E-01 0.000E+00 1.389E+00 2.07E-01 7.05E-04 2.077E-01 1.539E-01 3.340E-01 1.70E-03 1.005 e- 2.65E-02 4.608E-01 0.000E+00 1.382E+00 2.06E-01 7.12E-04 2.070E-01 1.571E-01 3.327E-01 1.69E-03 1.005 e- 2.55E-02 4.674E-01 0.000E+00 1.375E+00 2.06E-01 7.18E-04 2.062E-01 1.603E-01 3.314E-01 1.69E-03 1.005 e- 2.16E-02 4.741E-01 0.000E+00 1.368E+00 2.05E-01 7.25E-04 2.055E-01 1.636E-01 3.302E-01 1.68E-03 1.005 e- 2.18E-03 4.807E-01 0.000E+00 1.362E+00 2.04E-01 7.32E-04 2.049E-01 1.668E-01 3.290E-01 1.68E-03 1.005 e- 2.94E-04 4.873E-01 0.000E+00 1.355E+00 2.03E-01 7.39E-04 2.042E-01 1.700E-01 3.279E-01 1.67E-03 1.005 e- 1.18E-04 4.939E-01 0.000E+00 1.349E+00 2.03E-01 7.46E-04 2.036E-01 1.733E-01 3.268E-01 1.66E-03 1.005 e- 4.02E-28 5.006E-01 0.000E+00 1.343E+00 2.02E-01 7.53E-04 2.029E-01 1.765E-01 3.257E-01 1.66E-03 1.005 e- 4.02E-28 5.072E-01 0.000E+00 1.337E+00 2.02E-01 7.60E-04 2.023E-01 1.798E-01 3.247E-01 1.65E-03 1.005 e- 4.02E-28 5.138E-01 0.000E+00 1.331E+00 2.01E-01 7.67E-04 2.018E-01 1.831E-01 3.237E-01 1.65E-03 1.005 e- 4.02E-28 5.205E-01 0.000E+00 1.325E+00 2.00E-01 7.74E-04 2.012E-01 1.864E-01 3.227E-01 1.64E-03 1.005 e- 4.02E-28 5.271E-01 0.000E+00 1.320E+00 2.00E-01 7.81E-04 2.007E-01 1.897E-01 3.218E-01 1.64E-03 1.005 e- 4.02E-28 5.337E-01 0.000E+00 1.314E+00 1.99E-01 7.88E-04 2.001E-01 1.930E-01 3.209E-01 1.63E-03 1.005 e- 4.02E-28 5.403E-01 0.000E+00 1.309E+00 1.99E-01 7.96E-04 1.996E-01 1.963E-01 3.200E-01 1.63E-03 1.005 e- 4.02E-28 5.470E-01 0.000E+00 1.304E+00 1.98E-01 8.03E-04 1.991E-01 1.996E-01 3.192E-01 1.63E-03 1.005 e- 4.02E-28 5.536E-01 0.000E+00 1.299E+00 1.98E-01 8.10E-04 1.986E-01 2.030E-01 3.183E-01 1.62E-03 1.005 e- 4.02E-28 5.602E-01 0.000E+00 1.295E+00 1.97E-01 8.17E-04 1.982E-01 2.063E-01 3.175E-01 1.62E-03 1.005 e- 4.02E-28 5.669E-01 0.000E+00 1.290E+00 1.97E-01 8.24E-04 1.977E-01 2.097E-01 3.168E-01 1.61E-03 1.005 e- 4.02E-28 5.735E-01 0.000E+00 1.285E+00 1.96E-01 8.32E-04 1.973E-01 2.130E-01 3.160E-01 1.61E-03 1.005 e- 4.02E-28 5.801E-01 0.000E+00 1.281E+00 1.96E-01 8.39E-04 1.969E-01 2.164E-01 3.153E-01 1.61E-03 1.005 e- 4.02E-28 5.868E-01 0.000E+00 1.277E+00 1.96E-01 8.46E-04 1.964E-01 2.198E-01 3.146E-01 1.60E-03 1.005 e- 4.02E-28 5.934E-01 0.000E+00 1.272E+00 1.95E-01 8.54E-04 1.960E-01 2.231E-01 3.139E-01 1.60E-03 1.005 e- 4.02E-28 6.000E-01 0.000E+00 1.268E+00 1.95E-01 8.61E-04 1.957E-01 2.265E-01 3.132E-01 1.60E-03 1.005 e- 4.02E-28 6.067E-01 0.000E+00 1.264E+00 1.94E-01 8.69E-04 1.953E-01 2.299E-01 3.125E-01 1.59E-03 1.005 e- 4.02E-28 6.133E-01 0.000E+00 1.260E+00 1.94E-01 8.76E-04 1.949E-01 2.333E-01 3.119E-01 1.59E-03 1.005 e- 4.02E-28 6.199E-01 0.000E+00 1.257E+00 1.94E-01 8.83E-04 1.945E-01 2.367E-01 3.113E-01 1.59E-03 1.005 e- 4.02E-28 6.265E-01 0.000E+00 1.253E+00 1.93E-01 8.91E-04 1.942E-01 2.401E-01 3.107E-01 1.58E-03 1.005 e- 4.02E-28 6.332E-01 0.000E+00 1.249E+00 1.93E-01 8.98E-04 1.939E-01 2.435E-01 3.101E-01 1.58E-03 1.005 e- 4.02E-28 6.398E-01 0.000E+00 1.246E+00 1.93E-01 9.06E-04 1.935E-01 2.470E-01 3.095E-01 1.58E-03 1.005 e- 4.02E-28 6.464E-01 0.000E+00 1.242E+00 1.92E-01 9.13E-04 1.932E-01 2.504E-01 3.090E-01 1.57E-03 1.005 e- 4.02E-28 6.531E-01 0.000E+00 1.239E+00 1.92E-01 9.21E-04 1.929E-01 2.538E-01 3.084E-01 1.57E-03 1.005 e- 8.83E-05 6.597E-01 0.000E+00 1.235E+00 1.92E-01 9.29E-04 1.926E-01 2.573E-01 3.079E-01 1.57E-03 1.005 Avg 1.00E-02 2.685E-01 0.000E+00 2.785E+00 3.38E-01 5.43E-04 3.390E-01 7.737E-02 5.901E-01 3.01E-03 1.005 =================================================================================================================== ZEB = (zeff/beta)^2 (Barkas 1963); DPUF = absorbed dose per unit fluence (nGy-cm^2/particle); zf in units of Gy TABLE 1. Percent (%) cluster yields by complexity, as classified using the scheme of Nikjoo et al. (IJRB 71, 467-483 1997 and and Radiat. Res. 156, 577-583 2001). =================================================================================================================== 68.306 BD - one or more Bd (no Sb) 28.866 SSB - Sb (no auxilary damage) 1.314 SSB+ - two Sb on the same strand 0.165 2SSB - two or more Sb on opposite strands separated by at least 10 bp 1.169 DSB - two Sb on opposite strands with a separation <= 10 bp 0.161 DSB+ - DSB accompanied by one (or more) additional Sb within 10 bp separation 0.019 DSB++ - more than one DSB whether within the 10 bp separation or further apart 4.874 SSBc - fraction of complex damage (SSB+ and 2SSB) among SSBs 40.789 SSBcb - fraction of complex damage (SSB+ and 2SSB) among SSBs; base damage included 13.297 DSBc - fraction of complex damage (DSB+ and DSB++) among DSBs 51.613 DSBcb - fraction of complex damage (DSB+ and DSB++) among DSBs; base damage included =================================================================================================================== TABLE 2. Number of clusters per cell per Gy. Cluster yields are for a representative cell containing an average of 1.000 Gbp (giga basepair) of DNA. Cluster induction is proportional to absorbed dose up to at least a hundred or thousand Gy. The category "OTHER" includes all classes of individual and clustered DNA lesion, except for SSB and DSB. SEM = standard error of the mean. =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.12370E+02 1.48358E-02 3.37033E+02 2.98559E-02 4.49402E+02 3.67185E-02 2 4.04729E+00 3.55989E-03 5.08350E+01 1.14417E-02 7.05393E+01 1.28846E-02 1.25422E+02 1.68137E-02 3 2.54235E+00 2.84557E-03 1.76848E+01 7.24627E-03 1.47537E+01 6.56514E-03 3.49809E+01 9.82354E-03 4 1.09888E+00 1.89537E-03 5.57293E+00 4.24902E-03 3.08277E+00 3.14368E-03 9.75458E+00 5.50997E-03 5 4.07807E-01 1.15509E-03 1.66582E+00 2.35204E-03 6.44837E-01 1.45826E-03 2.71846E+00 2.98858E-03 6 1.40313E-01 6.81817E-04 4.83850E-01 1.27290E-03 1.33563E-01 6.70881E-04 7.57727E-01 1.59708E-03 7 4.63233E-02 3.91986E-04 1.35353E-01 6.77757E-04 2.84100E-02 3.09055E-04 2.10087E-01 8.40342E-04 8 1.46367E-02 2.20390E-04 3.76033E-02 3.55184E-04 6.18000E-03 1.43345E-04 5.84200E-02 4.41275E-04 9 4.90333E-03 1.27965E-04 1.05433E-02 1.87764E-04 1.30333E-03 6.59924E-05 1.67500E-02 2.37442E-04 10 1.39667E-03 6.82721E-05 2.91333E-03 9.89242E-05 2.93333E-04 3.12422E-05 4.60333E-03 1.24494E-04 11 4.13333E-04 3.70727E-05 7.80000E-04 5.10892E-05 3.66667E-05 1.10543E-05 1.23000E-03 6.39691E-05 12 1.43333E-04 2.18489E-05 2.40000E-04 2.82642E-05 3.33333E-06 3.33333E-06 3.86667E-04 3.61683E-05 13 4.33333E-05 1.20171E-05 4.66667E-05 1.24706E-05 --- --- 9.00000E-05 1.73160E-05 14 1.00000E-05 5.77339E-06 2.33333E-05 8.81864E-06 3.33333E-06 3.33333E-06 3.66667E-05 1.10543E-05 15 3.33333E-06 3.33333E-06 1.00000E-05 5.77339E-06 --- --- 1.33333E-05 6.66647E-06 16 --- --- --- --- --- --- --- --- 17 --- --- --- --- --- --- --- --- 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Total 8.30451E+00 4.88514E-03 1.88800E+02 1.11237E-02 4.26223E+02 2.30738E-02 6.23327E+02 2.44793E-02 ------------------------------------------------------------------------------------------------------------------- TABLE 3. Cluster composition (% Sb per cluster) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.66667E+01 0.00000E+00 0.00000E+00 0.00000E+00 4.16737E+00 4.31361E-04 2 1.66667E+01 0.00000E+00 8.95590E+00 5.57404E-04 0.00000E+00 0.00000E+00 4.16762E+00 7.01536E-04 3 1.20240E+01 2.43099E-03 6.51454E+00 9.55584E-04 0.00000E+00 0.00000E+00 4.16717E+00 1.20800E-03 4 9.80254E+00 4.27986E-03 5.36300E+00 1.66251E-03 0.00000E+00 0.00000E+00 4.16804E+00 2.09384E-03 5 8.52362E+00 7.40048E-03 4.71454E+00 3.03307E-03 0.00000E+00 0.00000E+00 4.16654E+00 3.67502E-03 6 7.70657E+00 1.14995E-02 4.29827E+00 5.88779E-03 0.00000E+00 0.00000E+00 4.17476E+00 7.07203E-03 7 7.13061E+00 1.84956E-02 4.03455E+00 9.99400E-03 0.00000E+00 0.00000E+00 4.17672E+00 1.22523E-02 8 6.66845E+00 2.99874E-02 3.83079E+00 1.73123E-02 0.00000E+00 0.00000E+00 4.14525E+00 2.01654E-02 9 6.38137E+00 5.07300E-02 3.64682E+00 3.06499E-02 0.00000E+00 0.00000E+00 4.15557E+00 3.47016E-02 10 6.14908E+00 9.09900E-02 3.59019E+00 5.62715E-02 0.00000E+00 0.00000E+00 4.12977E+00 6.21640E-02 11 5.90176E+00 1.77634E-01 3.26766E+00 9.45569E-02 0.00000E+00 0.00000E+00 4.05756E+00 1.12615E-01 12 5.52326E+00 2.90441E-01 3.47222E+00 1.86323E-01 0.00000E+00 0.00000E+00 4.17874E+00 1.85155E-01 13 5.62130E+00 5.14020E-01 3.57143E+00 3.34063E-01 --- --- 4.55840E+00 3.57765E-01 14 5.55556E+00 3.96825E-01 3.06122E+00 5.72534E-01 0.00000E+00 0.00000E+00 3.46320E+00 6.10298E-01 15 4.44444E+00 0.00000E+00 2.59259E+00 3.70370E-01 --- --- 3.05556E+00 5.31904E-01 16 --- --- --- --- --- --- --- --- 17 --- --- --- --- --- --- --- --- 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Average 1.37070E+01 2.20007E-03 1.31559E+01 6.00734E-04 0.00000E+00 0.00000E+00 4.16743E+00 1.86475E-04 ------------------------------------------------------------------------------------------------------------------- NOTES: (% Sb) is the percentage of lesions that are strand breaks. The number of Sb is ((% Sb)/100)*(# lesions). The number of Bd is (1-(% Sb)/100)*(# lesions). TABLE 4. Cluster Length (in base pair) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.66667E-01 0.00000E+00 1.66667E-01 0.00000E+00 1.66667E-01 0.00000E+00 2 9.11826E-01 4.24698E-04 9.37159E-01 1.13578E-04 9.35414E-01 9.65940E-05 9.35358E-01 7.25749E-05 3 1.60544E+00 7.40301E-04 1.72006E+00 2.74528E-04 1.70511E+00 3.02246E-04 1.70544E+00 1.95530E-04 4 2.33823E+00 1.47773E-03 2.50286E+00 5.96615E-04 2.47540E+00 8.16132E-04 2.47561E+00 4.49908E-04 5 3.08425E+00 2.96715E-03 3.28343E+00 1.32043E-03 3.24992E+00 2.33597E-03 3.24594E+00 1.01125E-03 6 3.86439E+00 5.26402E-03 4.07072E+00 3.00695E-03 4.01722E+00 5.37560E-03 4.02239E+00 2.38667E-03 7 4.62137E+00 9.49808E-03 4.84289E+00 5.79484E-03 4.80083E+00 1.19065E-02 4.78828E+00 4.83490E-03 8 5.36757E+00 1.82995E-02 5.62624E+00 1.12260E-02 5.55146E+00 2.79152E-02 5.55333E+00 9.27068E-03 9 6.17460E+00 3.36348E-02 6.42405E+00 2.20821E-02 6.31384E+00 6.43343E-02 6.34588E+00 1.80301E-02 10 6.88809E+00 6.37832E-02 7.14233E+00 4.54125E-02 7.13068E+00 1.45226E-01 7.06574E+00 3.61312E-02 11 7.58737E+00 1.16193E-01 7.98534E+00 9.14745E-02 7.31818E+00 3.72308E-01 7.83130E+00 7.14401E-02 12 8.31783E+00 2.15866E-01 8.81944E+00 1.84397E-01 8.66667E+00 0.00000E+00 8.63406E+00 1.41464E-01 13 9.60256E+00 4.97694E-01 8.80952E+00 4.00266E-01 --- --- 9.19136E+00 3.20343E-01 14 1.04444E+01 1.21843E+00 9.09524E+00 2.43587E-01 1.18333E+01 0.00000E+00 9.71212E+00 4.28228E-01 15 1.18333E+01 0.00000E+00 1.23889E+01 1.18764E+00 --- --- 1.22500E+01 8.51197E-01 16 --- --- --- --- --- --- --- --- 17 --- --- --- --- --- --- --- --- 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Average 1.50265E+00 6.26247E-04 6.31097E-01 1.03199E-04 3.70201E-01 4.38395E-05 4.64327E-01 4.70035E-05 ------------------------------------------------------------------------------------------------------------------- TABLE 5. NUMBER OF LESIONS DIVIDED BY TWICE THE CLUSTER LENGTH (lesions per nucleotide) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 8.33333E-02 0.00000E+00 8.33333E-02 0.00000E+00 8.33333E-02 0.00000E+00 2 4.53958E-02 3.44844E-05 4.12752E-02 7.74270E-06 4.15682E-02 6.72464E-06 4.15731E-02 5.04464E-06 3 3.17073E-02 2.13584E-05 2.91692E-02 7.09072E-06 2.94896E-02 7.90186E-06 2.94885E-02 5.11082E-06 4 2.72107E-02 2.33711E-05 2.50350E-02 8.35375E-06 2.53982E-02 1.16844E-05 2.53953E-02 6.45823E-06 5 2.48968E-02 3.09712E-05 2.30843E-02 1.20166E-05 2.33856E-02 2.17848E-05 2.34232E-02 9.44095E-06 6 2.32906E-02 3.89684E-05 2.19115E-02 1.97274E-05 2.22629E-02 3.66041E-05 2.22352E-02 1.64290E-05 7 2.23961E-02 5.44238E-05 2.12280E-02 2.99492E-05 2.14415E-02 6.26144E-05 2.15179E-02 2.56625E-05 8 2.18864E-02 8.68500E-05 2.07122E-02 4.73627E-05 2.10778E-02 1.22824E-04 2.10437E-02 4.06478E-05 9 2.12212E-02 1.28421E-04 2.02759E-02 8.06071E-05 2.06397E-02 2.20954E-04 2.05746E-02 6.64993E-05 10 2.09618E-02 2.15077E-04 2.01721E-02 1.36595E-04 2.02356E-02 4.45470E-04 2.04137E-02 1.12932E-04 11 2.07579E-02 3.40407E-04 1.97538E-02 2.39421E-04 2.14161E-02 1.07213E-03 2.01418E-02 1.94181E-04 12 2.07358E-02 6.87636E-04 1.95225E-02 4.29657E-04 1.92308E-02 0.00000E+00 1.99683E-02 3.73041E-04 13 1.93967E-02 9.73043E-04 2.10084E-02 8.78505E-04 --- --- 2.02324E-02 6.59873E-04 14 1.91747E-02 2.40158E-03 2.14693E-02 5.65487E-04 1.64319E-02 0.00000E+00 2.03856E-02 8.32781E-04 15 1.76056E-02 0.00000E+00 1.71138E-02 1.55723E-03 --- --- 1.72368E-02 1.10797E-03 16 --- --- --- --- --- --- --- --- 17 --- --- --- --- --- --- --- --- 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Average 3.72310E-02 1.88604E-05 6.44622E-02 3.79928E-06 7.40204E-02 1.96545E-06 7.06348E-02 1.86773E-06 ------------------------------------------------------------------------------------------------------------------- TABLE 6. Number of clusters per cell per Gy per track. Cluster yields are for a representative cell containing an average of 1.000 Gbp (giga basepair) of DNA. Cluster induction is proportional to absorbed dose up to at least a hundred or thousand Gy. The category "OTHER" includes all classes of individual and clustered DNA lesion, except for SSB and DSB. SEM = standard error of the mean. =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 3.36261E-01 1.72624E-03 1.00864E+00 5.18020E-03 1.34490E+00 6.90534E-03 2 1.21828E-02 6.69016E-05 1.52903E-01 8.04852E-04 2.12265E-01 1.11947E-03 3.77351E-01 1.98734E-03 3 7.69042E-03 4.35628E-05 5.35308E-02 2.92636E-04 4.45907E-02 2.41510E-04 1.05812E-01 5.73449E-04 4 3.33538E-03 2.04501E-05 1.69595E-02 9.60481E-05 9.39046E-03 5.43647E-05 2.96854E-02 1.66579E-04 5 1.24543E-03 8.85553E-06 5.09043E-03 3.06408E-05 1.96687E-03 1.31085E-05 8.30273E-03 4.86173E-05 6 4.31436E-04 4.09075E-06 1.47868E-03 1.01473E-05 4.07029E-04 3.91203E-06 2.31715E-03 1.49339E-05 7 1.45531E-04 2.17832E-06 4.13370E-04 3.98760E-06 8.63390E-05 1.54712E-06 6.45240E-04 5.48118E-06 8 4.49086E-05 1.07854E-06 1.15153E-04 1.80381E-06 1.89897E-05 6.93506E-07 1.79051E-04 2.33729E-06 9 1.52055E-05 6.09119E-07 3.40717E-05 1.10032E-06 3.75645E-06 2.62456E-07 5.30337E-05 1.29405E-06 10 4.16213E-06 3.24321E-07 9.25111E-06 5.20997E-07 8.11886E-07 1.01977E-07 1.42251E-05 6.47247E-07 11 1.14236E-06 1.24790E-07 2.29321E-06 2.25541E-07 9.91527E-08 3.29898E-08 3.53473E-06 2.59637E-07 12 5.06517E-07 1.47634E-07 6.95303E-07 1.11581E-07 5.90806E-09 0.00000E+00 1.20773E-06 1.85396E-07 13 2.45729E-07 1.34103E-07 1.46354E-07 5.25730E-08 --- --- 3.92083E-07 1.44035E-07 14 2.13066E-08 1.27730E-08 4.48491E-08 1.91692E-08 5.60563E-09 0.00000E+00 7.17613E-08 2.37060E-08 15 7.35207E-09 0.00000E+00 2.21993E-08 1.31969E-08 --- --- 2.95514E-08 1.51064E-08 16 --- --- --- --- --- --- --- --- 17 --- --- --- --- --- --- --- --- 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Total 2.50972E-02 1.37160E-04 5.66799E-01 2.95342E-03 1.27737E+00 6.60291E-03 1.86927E+00 9.69087E-03 -------------------------------------------------------------------------------------------------------------------