=============================== MCDS Version 3.00B 15-JUL-2011 =============================== 5.304 running time (min) 1.0000E+00 DNA content (Gbp) 5.0000E+00 Dia. of cell nucleus (um) 50000 number of cells (nocs) 987654321 random number seed MXRF TABLE: Particle types and properties of the (input) mixed radiation field. The hypoxia reduction factor (HRF) for DSB induction is estimated as [1/(1-pcr)]^2, where pcr = the probability a lesion undergoes chemical repair for the specified (input) oxygen concentration compared to fully aerobic (100% O2) conditions. The frequency-mean specific energy (zf) is for a spherical target representative of the cell nucleus. Radiative losses by the primary charged particle are assumed non-local and do not not contribute to specific energy or the dose per unit fluence (DPUF). The reported stopping power is at the point of entry into the cell nucleus (pO2 = 100.000%). =================================================================================================================== Normed -- Kinetic Energy -- Stopping Power (keV/um) CSDA Dosimetry (Gy) HRF Ion wt (MeV) (MeV/A) zeb Coll+Nuc Radiat Total Range (cm) DPUF zf DSB =================================================================================================================== e- 3.02E-03 6.700E-03 0.000E+00 3.889E+01 3.07E+00 3.91E-04 3.068E+00 1.310E-04 3.442E-01 1.75E-03 1.005 e- 4.12E-03 2.010E-02 0.000E+00 1.347E+01 1.33E+00 4.04E-04 1.335E+00 8.613E-04 4.564E+00 2.32E-02 1.005 e- 6.66E-03 3.350E-02 0.000E+00 8.385E+00 9.02E-01 4.00E-04 9.026E-01 2.111E-03 2.065E+00 1.05E-02 1.005 e- 7.47E-03 4.690E-02 0.000E+00 6.209E+00 7.01E-01 3.97E-04 7.019E-01 3.812E-03 1.414E+00 7.20E-03 1.005 e- 9.07E-03 6.030E-02 0.000E+00 5.001E+00 5.85E-01 3.98E-04 5.852E-01 5.915E-03 1.106E+00 5.63E-03 1.005 e- 9.69E-03 7.370E-02 0.000E+00 4.234E+00 5.08E-01 4.00E-04 5.087E-01 8.380E-03 9.256E-01 4.71E-03 1.005 e- 8.40E-03 8.710E-02 0.000E+00 3.703E+00 4.54E-01 4.04E-04 4.546E-01 1.117E-02 8.064E-01 4.11E-03 1.005 e- 1.01E-02 1.005E-01 0.000E+00 3.315E+00 4.14E-01 4.10E-04 4.144E-01 1.427E-02 7.219E-01 3.68E-03 1.005 e- 1.04E-02 1.139E-01 0.000E+00 3.018E+00 3.83E-01 4.16E-04 3.832E-01 1.763E-02 6.587E-01 3.35E-03 1.005 e- 9.98E-03 1.273E-01 0.000E+00 2.785E+00 3.58E-01 4.23E-04 3.584E-01 2.125E-02 6.097E-01 3.11E-03 1.005 e- 1.01E-02 1.407E-01 0.000E+00 2.596E+00 3.38E-01 4.31E-04 3.383E-01 2.510E-02 5.707E-01 2.91E-03 1.005 e- 9.04E-03 1.541E-01 0.000E+00 2.441E+00 3.21E-01 4.40E-04 3.216E-01 2.917E-02 5.389E-01 2.74E-03 1.005 e- 9.98E-03 1.675E-01 0.000E+00 2.311E+00 3.07E-01 4.49E-04 3.075E-01 3.343E-02 5.124E-01 2.61E-03 1.005 e- 1.04E-02 1.809E-01 0.000E+00 2.200E+00 2.95E-01 4.58E-04 2.955E-01 3.788E-02 4.901E-01 2.50E-03 1.005 e- 1.02E-02 1.943E-01 0.000E+00 2.105E+00 2.85E-01 4.68E-04 2.851E-01 4.250E-02 4.711E-01 2.40E-03 1.005 e- 1.11E-02 2.077E-01 0.000E+00 2.022E+00 2.76E-01 4.78E-04 2.761E-01 4.728E-02 4.547E-01 2.32E-03 1.005 e- 1.05E-02 2.211E-01 0.000E+00 1.950E+00 2.68E-01 4.89E-04 2.682E-01 5.220E-02 4.404E-01 2.24E-03 1.005 e- 1.06E-02 2.345E-01 0.000E+00 1.886E+00 2.61E-01 4.99E-04 2.612E-01 5.727E-02 4.279E-01 2.18E-03 1.005 e- 1.03E-02 2.479E-01 0.000E+00 1.829E+00 2.55E-01 5.11E-04 2.550E-01 6.246E-02 4.168E-01 2.12E-03 1.005 e- 1.01E-02 2.613E-01 0.000E+00 1.779E+00 2.49E-01 5.22E-04 2.495E-01 6.777E-02 4.069E-01 2.07E-03 1.005 e- 1.04E-02 2.747E-01 0.000E+00 1.733E+00 2.44E-01 5.33E-04 2.445E-01 7.320E-02 3.981E-01 2.03E-03 1.005 e- 1.01E-02 2.881E-01 0.000E+00 1.692E+00 2.39E-01 5.45E-04 2.400E-01 7.873E-02 3.902E-01 1.99E-03 1.005 e- 1.02E-02 3.015E-01 0.000E+00 1.654E+00 2.35E-01 5.57E-04 2.360E-01 8.436E-02 3.830E-01 1.95E-03 1.005 e- 9.93E-03 3.149E-01 0.000E+00 1.620E+00 2.32E-01 5.69E-04 2.323E-01 9.008E-02 3.765E-01 1.92E-03 1.005 e- 9.79E-03 3.283E-01 0.000E+00 1.589E+00 2.28E-01 5.81E-04 2.289E-01 9.590E-02 3.706E-01 1.89E-03 1.005 e- 9.79E-03 3.417E-01 0.000E+00 1.560E+00 2.25E-01 5.94E-04 2.258E-01 1.018E-01 3.653E-01 1.86E-03 1.005 e- 9.53E-03 3.551E-01 0.000E+00 1.534E+00 2.22E-01 6.07E-04 2.230E-01 1.078E-01 3.603E-01 1.84E-03 1.005 e- 9.34E-03 3.685E-01 0.000E+00 1.510E+00 2.20E-01 6.19E-04 2.204E-01 1.138E-01 3.558E-01 1.81E-03 1.005 e- 9.12E-03 3.819E-01 0.000E+00 1.487E+00 2.17E-01 6.32E-04 2.180E-01 1.199E-01 3.516E-01 1.79E-03 1.005 e- 1.06E-02 3.953E-01 0.000E+00 1.466E+00 2.15E-01 6.45E-04 2.157E-01 1.261E-01 3.478E-01 1.77E-03 1.005 e- 9.69E-03 4.087E-01 0.000E+00 1.447E+00 2.13E-01 6.59E-04 2.137E-01 1.323E-01 3.442E-01 1.75E-03 1.005 e- 9.77E-03 4.221E-01 0.000E+00 1.428E+00 2.11E-01 6.72E-04 2.118E-01 1.386E-01 3.409E-01 1.74E-03 1.005 e- 9.77E-03 4.355E-01 0.000E+00 1.411E+00 2.09E-01 6.86E-04 2.100E-01 1.450E-01 3.379E-01 1.72E-03 1.005 e- 1.03E-02 4.489E-01 0.000E+00 1.395E+00 2.08E-01 6.99E-04 2.083E-01 1.514E-01 3.350E-01 1.71E-03 1.005 e- 1.01E-02 4.623E-01 0.000E+00 1.381E+00 2.06E-01 7.13E-04 2.068E-01 1.579E-01 3.324E-01 1.69E-03 1.005 e- 1.03E-02 4.757E-01 0.000E+00 1.367E+00 2.05E-01 7.27E-04 2.054E-01 1.644E-01 3.299E-01 1.68E-03 1.005 e- 9.95E-03 4.891E-01 0.000E+00 1.353E+00 2.03E-01 7.41E-04 2.040E-01 1.709E-01 3.276E-01 1.67E-03 1.005 e- 9.93E-03 5.025E-01 0.000E+00 1.341E+00 2.02E-01 7.55E-04 2.028E-01 1.775E-01 3.254E-01 1.66E-03 1.005 e- 8.88E-03 5.159E-01 0.000E+00 1.329E+00 2.01E-01 7.69E-04 2.016E-01 1.841E-01 3.234E-01 1.65E-03 1.005 e- 9.82E-03 5.293E-01 0.000E+00 1.318E+00 2.00E-01 7.84E-04 2.005E-01 1.908E-01 3.215E-01 1.64E-03 1.005 e- 9.95E-03 5.427E-01 0.000E+00 1.308E+00 1.99E-01 7.98E-04 1.994E-01 1.975E-01 3.197E-01 1.63E-03 1.005 e- 1.05E-02 5.561E-01 0.000E+00 1.298E+00 1.98E-01 8.13E-04 1.985E-01 2.042E-01 3.180E-01 1.62E-03 1.005 e- 9.15E-03 5.695E-01 0.000E+00 1.288E+00 1.97E-01 8.27E-04 1.975E-01 2.110E-01 3.165E-01 1.61E-03 1.005 e- 9.66E-03 5.829E-01 0.000E+00 1.279E+00 1.96E-01 8.42E-04 1.967E-01 2.178E-01 3.150E-01 1.60E-03 1.005 e- 9.77E-03 5.963E-01 0.000E+00 1.271E+00 1.95E-01 8.57E-04 1.959E-01 2.246E-01 3.136E-01 1.60E-03 1.005 e- 1.08E-02 6.097E-01 0.000E+00 1.262E+00 1.94E-01 8.72E-04 1.951E-01 2.315E-01 3.122E-01 1.59E-03 1.005 e- 9.95E-03 6.231E-01 0.000E+00 1.255E+00 1.93E-01 8.87E-04 1.944E-01 2.384E-01 3.110E-01 1.58E-03 1.005 e- 1.08E-02 6.365E-01 0.000E+00 1.247E+00 1.93E-01 9.02E-04 1.937E-01 2.453E-01 3.098E-01 1.58E-03 1.005 e- 1.02E-02 6.499E-01 0.000E+00 1.240E+00 1.92E-01 9.17E-04 1.930E-01 2.522E-01 3.087E-01 1.57E-03 1.005 e- 1.01E-02 6.633E-01 0.000E+00 1.234E+00 1.91E-01 9.33E-04 1.924E-01 2.591E-01 3.076E-01 1.57E-03 1.005 e- 9.15E-03 6.767E-01 0.000E+00 1.227E+00 1.91E-01 9.48E-04 1.919E-01 2.661E-01 3.066E-01 1.56E-03 1.005 e- 1.01E-02 6.901E-01 0.000E+00 1.221E+00 1.90E-01 9.64E-04 1.913E-01 2.731E-01 3.057E-01 1.56E-03 1.005 e- 1.01E-02 7.035E-01 0.000E+00 1.215E+00 1.90E-01 9.79E-04 1.908E-01 2.801E-01 3.048E-01 1.55E-03 1.005 e- 1.06E-02 7.169E-01 0.000E+00 1.209E+00 1.89E-01 9.95E-04 1.903E-01 2.872E-01 3.039E-01 1.55E-03 1.005 e- 1.07E-02 7.303E-01 0.000E+00 1.204E+00 1.89E-01 1.01E-03 1.898E-01 2.942E-01 3.031E-01 1.54E-03 1.005 e- 1.06E-02 7.437E-01 0.000E+00 1.199E+00 1.88E-01 1.03E-03 1.894E-01 3.013E-01 3.024E-01 1.54E-03 1.005 e- 9.47E-03 7.571E-01 0.000E+00 1.194E+00 1.88E-01 1.04E-03 1.890E-01 3.084E-01 3.016E-01 1.54E-03 1.005 e- 1.17E-02 7.705E-01 0.000E+00 1.189E+00 1.88E-01 1.06E-03 1.886E-01 3.155E-01 3.010E-01 1.53E-03 1.005 e- 1.09E-02 7.839E-01 0.000E+00 1.184E+00 1.87E-01 1.07E-03 1.882E-01 3.226E-01 3.003E-01 1.53E-03 1.005 e- 1.16E-02 7.973E-01 0.000E+00 1.180E+00 1.87E-01 1.09E-03 1.878E-01 3.297E-01 2.997E-01 1.53E-03 1.005 e- 1.22E-02 8.107E-01 0.000E+00 1.176E+00 1.86E-01 1.11E-03 1.875E-01 3.368E-01 2.991E-01 1.52E-03 1.005 e- 1.11E-02 8.241E-01 0.000E+00 1.172E+00 1.86E-01 1.12E-03 1.872E-01 3.440E-01 2.985E-01 1.52E-03 1.005 e- 1.23E-02 8.375E-01 0.000E+00 1.168E+00 1.86E-01 1.14E-03 1.869E-01 3.512E-01 2.980E-01 1.52E-03 1.005 e- 1.17E-02 8.509E-01 0.000E+00 1.164E+00 1.85E-01 1.16E-03 1.866E-01 3.583E-01 2.975E-01 1.52E-03 1.005 e- 1.38E-02 8.643E-01 0.000E+00 1.160E+00 1.85E-01 1.17E-03 1.863E-01 3.655E-01 2.970E-01 1.51E-03 1.005 e- 1.30E-02 8.777E-01 0.000E+00 1.157E+00 1.85E-01 1.19E-03 1.861E-01 3.727E-01 2.965E-01 1.51E-03 1.005 e- 1.33E-02 8.911E-01 0.000E+00 1.153E+00 1.85E-01 1.21E-03 1.858E-01 3.799E-01 2.961E-01 1.51E-03 1.005 e- 1.20E-02 9.045E-01 0.000E+00 1.150E+00 1.84E-01 1.22E-03 1.856E-01 3.871E-01 2.957E-01 1.51E-03 1.005 e- 1.35E-02 9.179E-01 0.000E+00 1.147E+00 1.84E-01 1.24E-03 1.854E-01 3.944E-01 2.953E-01 1.50E-03 1.005 e- 1.53E-02 9.313E-01 0.000E+00 1.144E+00 1.84E-01 1.26E-03 1.852E-01 4.016E-01 2.949E-01 1.50E-03 1.005 e- 1.43E-02 9.447E-01 0.000E+00 1.141E+00 1.84E-01 1.27E-03 1.850E-01 4.088E-01 2.945E-01 1.50E-03 1.005 e- 1.54E-02 9.581E-01 0.000E+00 1.138E+00 1.83E-01 1.29E-03 1.848E-01 4.161E-01 2.942E-01 1.50E-03 1.005 e- 1.66E-02 9.715E-01 0.000E+00 1.135E+00 1.83E-01 1.31E-03 1.846E-01 4.233E-01 2.938E-01 1.50E-03 1.005 e- 1.63E-02 9.849E-01 0.000E+00 1.132E+00 1.83E-01 1.32E-03 1.844E-01 4.306E-01 2.935E-01 1.49E-03 1.005 e- 1.78E-02 9.983E-01 0.000E+00 1.129E+00 1.83E-01 1.34E-03 1.843E-01 4.379E-01 2.932E-01 1.49E-03 1.005 e- 1.80E-02 1.012E+00 0.000E+00 1.127E+00 1.83E-01 1.36E-03 1.841E-01 4.452E-01 2.930E-01 1.49E-03 1.005 e- 1.87E-02 1.025E+00 0.000E+00 1.124E+00 1.83E-01 1.38E-03 1.840E-01 4.524E-01 2.927E-01 1.49E-03 1.005 e- 2.08E-02 1.038E+00 0.000E+00 1.122E+00 1.82E-01 1.39E-03 1.838E-01 4.597E-01 2.924E-01 1.49E-03 1.005 e- 2.28E-02 1.052E+00 0.000E+00 1.120E+00 1.82E-01 1.41E-03 1.837E-01 4.670E-01 2.922E-01 1.49E-03 1.005 e- 2.25E-02 1.065E+00 0.000E+00 1.117E+00 1.82E-01 1.43E-03 1.836E-01 4.743E-01 2.920E-01 1.49E-03 1.005 e- 2.62E-02 1.079E+00 0.000E+00 1.115E+00 1.82E-01 1.45E-03 1.835E-01 4.816E-01 2.917E-01 1.49E-03 1.005 e- 2.81E-02 1.092E+00 0.000E+00 1.113E+00 1.82E-01 1.46E-03 1.834E-01 4.889E-01 2.915E-01 1.48E-03 1.005 e- 3.10E-02 1.105E+00 0.000E+00 1.111E+00 1.82E-01 1.48E-03 1.833E-01 4.962E-01 2.913E-01 1.48E-03 1.005 e- 1.84E-02 1.119E+00 0.000E+00 1.109E+00 1.82E-01 1.50E-03 1.832E-01 5.035E-01 2.911E-01 1.48E-03 1.005 e- 2.89E-04 1.132E+00 0.000E+00 1.107E+00 1.82E-01 1.52E-03 1.831E-01 5.109E-01 2.909E-01 1.48E-03 1.005 e- 3.21E-05 1.146E+00 0.000E+00 1.105E+00 1.81E-01 1.53E-03 1.830E-01 5.182E-01 2.908E-01 1.48E-03 1.005 e- 1.06E-27 1.159E+00 0.000E+00 1.103E+00 1.81E-01 1.55E-03 1.829E-01 5.255E-01 2.906E-01 1.48E-03 1.005 e- 1.06E-27 1.173E+00 0.000E+00 1.101E+00 1.81E-01 1.57E-03 1.828E-01 5.328E-01 2.905E-01 1.48E-03 1.005 e- 1.06E-27 1.186E+00 0.000E+00 1.100E+00 1.81E-01 1.59E-03 1.828E-01 5.402E-01 2.903E-01 1.48E-03 1.005 e- 1.06E-27 1.199E+00 0.000E+00 1.098E+00 1.81E-01 1.61E-03 1.827E-01 5.475E-01 2.902E-01 1.48E-03 1.005 e- 1.06E-27 1.213E+00 0.000E+00 1.096E+00 1.81E-01 1.62E-03 1.826E-01 5.548E-01 2.900E-01 1.48E-03 1.005 e- 1.06E-27 1.226E+00 0.000E+00 1.095E+00 1.81E-01 1.64E-03 1.826E-01 5.622E-01 2.899E-01 1.48E-03 1.005 e- 1.06E-27 1.240E+00 0.000E+00 1.093E+00 1.81E-01 1.66E-03 1.825E-01 5.695E-01 2.898E-01 1.48E-03 1.005 e- 1.06E-27 1.253E+00 0.000E+00 1.092E+00 1.81E-01 1.68E-03 1.825E-01 5.769E-01 2.897E-01 1.48E-03 1.005 e- 1.06E-27 1.266E+00 0.000E+00 1.090E+00 1.81E-01 1.70E-03 1.824E-01 5.842E-01 2.896E-01 1.47E-03 1.005 e- 1.06E-27 1.280E+00 0.000E+00 1.089E+00 1.81E-01 1.71E-03 1.824E-01 5.915E-01 2.895E-01 1.47E-03 1.005 e- 1.06E-27 1.293E+00 0.000E+00 1.087E+00 1.81E-01 1.73E-03 1.824E-01 5.989E-01 2.894E-01 1.47E-03 1.005 e- 1.06E-27 1.306E+00 0.000E+00 1.086E+00 1.81E-01 1.75E-03 1.823E-01 6.062E-01 2.893E-01 1.47E-03 1.005 e- 1.06E-27 1.320E+00 0.000E+00 1.084E+00 1.81E-01 1.77E-03 1.823E-01 6.136E-01 2.892E-01 1.47E-03 1.005 e- 1.06E-27 1.333E+00 0.000E+00 1.083E+00 1.80E-01 1.79E-03 1.823E-01 6.209E-01 2.892E-01 1.47E-03 1.005 Avg 1.00E-02 6.559E-01 0.000E+00 1.718E+00 2.39E-01 9.58E-04 2.403E-01 2.658E-01 3.932E-01 2.00E-03 1.005 =================================================================================================================== ZEB = (zeff/beta)^2 (Barkas 1963); DPUF = absorbed dose per unit fluence (nGy-cm^2/particle); zf in units of Gy TABLE 1. Percent (%) cluster yields by complexity, as classified using the scheme of Nikjoo et al. (IJRB 71, 467-483 1997 and and Radiat. Res. 156, 577-583 2001). =================================================================================================================== 68.365 BD - one or more Bd (no Sb) 28.843 SSB - Sb (no auxilary damage) 1.298 SSB+ - two Sb on the same strand 0.162 2SSB - two or more Sb on opposite strands separated by at least 10 bp 1.157 DSB - two Sb on opposite strands with a separation <= 10 bp 0.158 DSB+ - DSB accompanied by one (or more) additional Sb within 10 bp separation 0.018 DSB++ - more than one DSB whether within the 10 bp separation or further apart 4.818 SSBc - fraction of complex damage (SSB+ and 2SSB) among SSBs 40.537 SSBcb - fraction of complex damage (SSB+ and 2SSB) among SSBs; base damage included 13.193 DSBc - fraction of complex damage (DSB+ and DSB++) among DSBs 51.334 DSBcb - fraction of complex damage (DSB+ and DSB++) among DSBs; base damage included =================================================================================================================== TABLE 2. Number of clusters per cell per Gy. Cluster yields are for a representative cell containing an average of 1.000 Gbp (giga basepair) of DNA. Cluster induction is proportional to absorbed dose up to at least a hundred or thousand Gy. The category "OTHER" includes all classes of individual and clustered DNA lesion, except for SSB and DSB. SEM = standard error of the mean. =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.12604E+02 1.42119E-02 3.37727E+02 2.72440E-02 4.50331E+02 3.27561E-02 2 4.04401E+00 3.55177E-03 5.08264E+01 1.13415E-02 7.04951E+01 1.29114E-02 1.25365E+02 1.67463E-02 3 2.53248E+00 2.84285E-03 1.76144E+01 7.15831E-03 1.46966E+01 6.51986E-03 3.48435E+01 9.65037E-03 4 1.08956E+00 1.88958E-03 5.53476E+00 4.18515E-03 3.06564E+00 3.13143E-03 9.68997E+00 5.42918E-03 5 4.05990E-01 1.15893E-03 1.65330E+00 2.31406E-03 6.43367E-01 1.44810E-03 2.70266E+00 2.92290E-03 6 1.40490E-01 6.82646E-04 4.77557E-01 1.25583E-03 1.33100E-01 6.66656E-04 7.51147E-01 1.57315E-03 7 4.60433E-02 3.90801E-04 1.34720E-01 6.68312E-04 2.77867E-02 3.04529E-04 2.08550E-01 8.33938E-04 8 1.48400E-02 2.21953E-04 3.76200E-02 3.53282E-04 5.83333E-03 1.39634E-04 5.82933E-02 4.40703E-04 9 4.25667E-03 1.19462E-04 1.00267E-02 1.83821E-04 1.10333E-03 6.06278E-05 1.53867E-02 2.26322E-04 10 1.38667E-03 6.80316E-05 2.82000E-03 9.73940E-05 2.56667E-04 2.92276E-05 4.46333E-03 1.22164E-04 11 4.10000E-04 3.69233E-05 7.66667E-04 5.04366E-05 2.66667E-05 9.42743E-06 1.20333E-03 6.31049E-05 12 8.66667E-05 1.69925E-05 1.86667E-04 2.53724E-05 6.66667E-06 4.71400E-06 2.80000E-04 3.08870E-05 13 1.00000E-05 5.77339E-06 7.00000E-05 1.52722E-05 --- --- 8.00000E-05 1.63262E-05 14 1.00000E-05 5.77339E-06 --- --- --- --- 1.00000E-05 5.77339E-06 15 6.66667E-06 4.71400E-06 6.66667E-06 4.71400E-06 --- --- 1.33333E-05 6.66647E-06 16 3.33333E-06 3.33333E-06 --- --- --- --- 3.33333E-06 3.33333E-06 17 3.33333E-06 3.33333E-06 --- --- --- --- 3.33333E-06 3.33333E-06 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Total 8.27959E+00 4.82867E-03 1.88897E+02 1.09674E-02 4.26796E+02 2.05112E-02 6.23972E+02 2.14074E-02 ------------------------------------------------------------------------------------------------------------------- TABLE 3. Cluster composition (% Sb per cluster) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.66667E+01 0.00000E+00 0.00000E+00 0.00000E+00 4.16747E+00 4.31578E-04 2 1.66667E+01 0.00000E+00 8.95455E+00 5.54484E-04 0.00000E+00 0.00000E+00 4.16791E+00 7.03074E-04 3 1.20227E+01 2.44116E-03 6.51587E+00 9.52731E-04 0.00000E+00 0.00000E+00 4.16759E+00 1.21413E-03 4 9.80644E+00 4.34357E-03 5.36491E+00 1.66733E-03 0.00000E+00 0.00000E+00 4.16666E+00 2.09441E-03 5 8.53084E+00 7.44416E-03 4.70919E+00 3.02950E-03 0.00000E+00 0.00000E+00 4.16151E+00 3.66223E-03 6 7.69964E+00 1.14254E-02 4.29101E+00 5.96826E-03 0.00000E+00 0.00000E+00 4.17169E+00 7.11378E-03 7 7.09329E+00 1.83173E-02 4.00781E+00 1.00101E-02 0.00000E+00 0.00000E+00 4.15608E+00 1.21651E-02 8 6.62562E+00 3.03205E-02 3.83832E+00 1.73279E-02 0.00000E+00 0.00000E+00 4.16834E+00 2.00049E-02 9 6.35773E+00 5.24892E-02 3.67873E+00 3.16067E-02 0.00000E+00 0.00000E+00 4.15020E+00 3.52209E-02 10 6.03261E+00 8.97060E-02 3.55389E+00 5.74739E-02 0.00000E+00 0.00000E+00 4.11423E+00 6.19964E-02 11 5.94974E+00 1.71538E-01 3.51779E+00 1.07714E-01 0.00000E+00 0.00000E+00 4.26845E+00 1.13551E-01 12 5.87607E+00 4.02595E-01 3.33333E+00 1.78761E-01 0.00000E+00 0.00000E+00 4.04953E+00 2.26126E-01 13 3.84615E+00 7.40193E-01 4.09035E+00 3.49642E-01 --- --- 4.05983E+00 3.15047E-01 14 6.34921E+00 1.04990E+00 --- --- --- --- 6.34921E+00 1.04990E+00 15 5.00000E+00 5.55556E-01 2.22222E+00 0.00000E+00 --- --- 3.61111E+00 8.33333E-01 16 5.20833E+00 0.00000E+00 --- --- --- --- 5.20833E+00 0.00000E+00 17 3.92157E+00 0.00000E+00 --- --- --- --- 3.92157E+00 0.00000E+00 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Average 1.37133E+01 2.19542E-03 1.31652E+01 5.73071E-04 0.00000E+00 0.00000E+00 4.16752E+00 1.86320E-04 ------------------------------------------------------------------------------------------------------------------- NOTES: (% Sb) is the percentage of lesions that are strand breaks. The number of Sb is ((% Sb)/100)*(# lesions). The number of Bd is (1-(% Sb)/100)*(# lesions). TABLE 4. Cluster Length (in base pair) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 1.66667E-01 0.00000E+00 1.66667E-01 0.00000E+00 1.66667E-01 0.00000E+00 2 9.11708E-01 4.23666E-04 9.37391E-01 1.13225E-04 9.35548E-01 9.65896E-05 9.35528E-01 7.24244E-05 3 1.60583E+00 7.37174E-04 1.72060E+00 2.73968E-04 1.70501E+00 2.98328E-04 1.70569E+00 1.93222E-04 4 2.33583E+00 1.48765E-03 2.50264E+00 6.04436E-04 2.47620E+00 8.23402E-04 2.47557E+00 4.54158E-04 5 3.09177E+00 2.97725E-03 3.28607E+00 1.32780E-03 3.24334E+00 2.35207E-03 3.24691E+00 1.01469E-03 6 3.85214E+00 5.29487E-03 4.05924E+00 3.03053E-03 4.02654E+00 5.36917E-03 4.01505E+00 2.39035E-03 7 4.61783E+00 9.59769E-03 4.84502E+00 5.78499E-03 4.79876E+00 1.22660E-02 4.78686E+00 4.84984E-03 8 5.42444E+00 1.79561E-02 5.61958E+00 1.12064E-02 5.61474E+00 2.80812E-02 5.56941E+00 9.19929E-03 9 6.19265E+00 3.58271E-02 6.40502E+00 2.29917E-02 6.26818E+00 6.93220E-02 6.33844E+00 1.87327E-02 10 6.88667E+00 6.53993E-02 7.16058E+00 4.41062E-02 7.03030E+00 1.48846E-01 7.07051E+00 3.56793E-02 11 8.10027E+00 1.40812E-01 7.84928E+00 8.67030E-02 8.62500E+00 5.47134E-01 7.95199E+00 7.43806E-02 12 8.47436E+00 3.77429E-01 8.87424E+00 1.72267E-01 1.05833E+01 1.08333E+00 8.79016E+00 1.68174E-01 13 9.38889E+00 6.26079E-01 9.38889E+00 3.41242E-01 --- --- 9.38889E+00 3.04731E-01 14 1.19444E+01 1.05556E+00 --- --- --- --- 1.19444E+01 1.05556E+00 15 1.03333E+01 2.33333E+00 1.15833E+01 5.83333E-01 --- --- 1.09583E+01 1.04610E+00 16 1.25000E+01 0.00000E+00 --- --- --- --- 1.25000E+01 0.00000E+00 17 1.08333E+01 0.00000E+00 --- --- --- --- 1.08333E+01 0.00000E+00 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Average 1.50125E+00 6.20341E-04 6.29497E-01 9.81193E-05 3.69527E-01 4.20508E-05 4.63254E-01 4.22752E-05 ------------------------------------------------------------------------------------------------------------------- TABLE 5. NUMBER OF LESIONS DIVIDED BY TWICE THE CLUSTER LENGTH (lesions per nucleotide) =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 8.33333E-02 0.00000E+00 8.33333E-02 0.00000E+00 8.33333E-02 0.00000E+00 2 4.54513E-02 3.47028E-05 4.12494E-02 7.74307E-06 4.15647E-02 6.71362E-06 4.15621E-02 5.03577E-06 3 3.17046E-02 2.12833E-05 2.91631E-02 7.08220E-06 2.95047E-02 7.84599E-06 2.94914E-02 5.08186E-06 4 2.72246E-02 2.33426E-05 2.50303E-02 8.46738E-06 2.53829E-02 1.17395E-05 2.53889E-02 6.50601E-06 5 2.48250E-02 3.04512E-05 2.30501E-02 1.19964E-05 2.34469E-02 2.19001E-05 2.34096E-02 9.45469E-06 6 2.33970E-02 3.93202E-05 2.19784E-02 2.00954E-05 2.22121E-02 3.63509E-05 2.22808E-02 1.63395E-05 7 2.24472E-02 5.60061E-05 2.12057E-02 2.96560E-05 2.15120E-02 6.60456E-05 2.15308E-02 2.59189E-05 8 2.16143E-02 8.33377E-05 2.07300E-02 4.73285E-05 2.07659E-02 1.18154E-04 2.09554E-02 3.98245E-05 9 2.11595E-02 1.40639E-04 2.03429E-02 8.15285E-05 2.08778E-02 2.69359E-04 2.05984E-02 6.89618E-05 10 2.10489E-02 2.37762E-04 2.00546E-02 1.31925E-04 2.05105E-02 4.88038E-04 2.03812E-02 1.15606E-04 11 1.96217E-02 3.70441E-04 2.00558E-02 2.42570E-04 1.82382E-02 1.19176E-03 1.98676E-02 2.01462E-04 12 2.06001E-02 8.52995E-04 1.92677E-02 4.62588E-04 1.59148E-02 1.62907E-03 1.96043E-02 4.15153E-04 13 1.94026E-02 1.29096E-03 1.97431E-02 7.10112E-04 --- --- 1.97005E-02 6.34304E-04 14 1.65628E-02 1.60558E-03 --- --- --- --- 1.65628E-02 1.60558E-03 15 2.12445E-02 4.79715E-03 1.80313E-02 9.08053E-04 --- --- 1.96379E-02 2.19846E-03 16 1.77778E-02 0.00000E+00 --- --- --- --- 1.77778E-02 0.00000E+00 17 2.17949E-02 0.00000E+00 --- --- --- --- 2.17949E-02 0.00000E+00 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Average 3.72694E-02 1.89845E-05 6.45046E-02 3.68704E-06 7.40478E-02 1.91041E-06 7.06705E-02 1.74571E-06 ------------------------------------------------------------------------------------------------------------------- TABLE 6. Number of clusters per cell per Gy per track. Cluster yields are for a representative cell containing an average of 1.000 Gbp (giga basepair) of DNA. Cluster induction is proportional to absorbed dose up to at least a hundred or thousand Gy. The category "OTHER" includes all classes of individual and clustered DNA lesion, except for SSB and DSB. SEM = standard error of the mean. =================================================================================================================== Number of --------- DSB ---------- --------- SSB ---------- -------- OTHER --------- ----- ALL CLUSTERS ----- lesions Average SEM Average SEM Average SEM Average SEM =================================================================================================================== 1 --- --- 2.25058E-01 8.58701E-04 6.74891E-01 2.56698E-03 8.99948E-01 3.42497E-03 2 8.09692E-03 3.27651E-05 1.01852E-01 3.98327E-04 1.41255E-01 5.52739E-04 2.51204E-01 9.81347E-04 3 5.07896E-03 2.13145E-05 3.53663E-02 1.41331E-04 2.95262E-02 1.19144E-04 6.99715E-02 2.78971E-04 4 2.19066E-03 1.01292E-05 1.11537E-02 4.71670E-05 6.17152E-03 2.64808E-05 1.95158E-02 8.10443E-05 5 8.20184E-04 4.68012E-06 3.34560E-03 1.56959E-05 1.30111E-03 6.82120E-06 5.46689E-03 2.46596E-05 6 2.81909E-04 2.11973E-06 9.66685E-04 5.22761E-06 2.68530E-04 2.14930E-06 1.51712E-03 7.49734E-06 7 9.33926E-05 1.14962E-06 2.74266E-04 2.26180E-06 5.58762E-05 8.51793E-07 4.23535E-04 3.02637E-06 8 3.00720E-05 6.01513E-07 7.55584E-05 9.90694E-07 1.15307E-05 3.44110E-07 1.17161E-04 1.24102E-06 9 8.54511E-06 3.15269E-07 1.99764E-05 4.81277E-07 2.49336E-06 2.19624E-07 3.10149E-05 6.12738E-07 10 2.93689E-06 2.07675E-07 5.52471E-06 2.30859E-07 5.76023E-07 1.03082E-07 9.03762E-06 3.30594E-07 11 9.44204E-07 1.35579E-07 1.51586E-06 1.32408E-07 4.58812E-08 1.65766E-08 2.50595E-06 1.90070E-07 12 1.49316E-07 2.96345E-08 3.93836E-07 6.49355E-08 1.03232E-08 7.30314E-09 5.53476E-07 7.17327E-08 13 2.83365E-08 1.81463E-08 1.41180E-07 3.28918E-08 --- --- 1.69516E-07 3.75633E-08 14 1.53158E-08 8.84849E-09 --- --- --- --- 1.53158E-08 8.84849E-09 15 1.09859E-08 7.80661E-09 1.12347E-08 8.00121E-09 --- --- 2.22206E-08 1.11784E-08 16 5.73596E-09 0.00000E+00 --- --- --- --- 5.73596E-09 0.00000E+00 17 5.39915E-09 0.00000E+00 --- --- --- --- 5.39915E-09 0.00000E+00 18 --- --- --- --- --- --- --- --- 19 --- --- --- --- --- --- --- --- 20 --- --- --- --- --- --- --- --- 21 --- --- --- --- --- --- --- --- 22 --- --- --- --- --- --- --- --- 23 --- --- --- --- --- --- --- --- 24 --- --- --- --- --- --- --- --- 25 --- --- --- --- --- --- --- --- 26 --- --- --- --- --- --- --- --- 27 --- --- --- --- --- --- --- --- 28 --- --- --- --- --- --- --- --- 29 --- --- --- --- --- --- --- --- 30 --- --- --- --- --- --- --- --- 31 --- --- --- --- --- --- --- --- 32 --- --- --- --- --- --- --- --- 33 --- --- --- --- --- --- --- --- 34 --- --- --- --- --- --- --- --- 35 --- --- --- --- --- --- --- --- 36 --- --- --- --- --- --- --- --- 37 --- --- --- --- --- --- --- --- 38 --- --- --- --- --- --- --- --- 39 --- --- --- --- --- --- --- --- 40 --- --- --- --- --- --- --- --- 41 --- --- --- --- --- --- --- --- 42 --- --- --- --- --- --- --- --- 43 --- --- --- --- --- --- --- --- 44 --- --- --- --- --- --- --- --- 45 --- --- --- --- --- --- --- --- 46 --- --- --- --- --- --- --- --- 47 --- --- --- --- --- --- --- --- 48 --- --- --- --- --- --- --- --- 49 --- --- --- --- --- --- --- --- 50 --- --- --- --- --- --- --- --- Total 1.66047E-02 6.65214E-05 3.78119E-01 1.46130E-03 8.53484E-01 3.26791E-03 1.24821E+00 4.79403E-03 -------------------------------------------------------------------------------------------------------------------