/*
 Measured C3H 10T1/2 cell survival data from

 REFERENCE:
  Wells R.L. and Bedford J.S., (1983). Dose-rate effects in mammalian cells. IV.
  Repairable and nonrepairable damage in noncycling C3H 10T 1/2 cells. Radiat.
  Res. 94(1), 105-134.

 PREPARED BY: JULIEN PARTOUCHE (JULIEN@TAMU.edu)
 DATE: 22-JUL-2003
*/
  
MODEL: DRM=TLK CKM=QECK
CELL: DNA=5.667D+09 NC=46
IRAD: CL=DSB
CLRP: RHT=HT4R BMR=6.6925972E-04 PHI=PML A0=PMR
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data

! TLK model inputs (simple and complex double strand breaks)
DSB = 30 2.0145345E+00 / !Radiation damage to DNA
HT4R = 1.3592738E-01 8.6513721E+00 / !Half-times for DSB repair
PML = 1.0665171E-02 / !Probability a misrejoined DSB is lethal
PMR = 0.75 0.25 / !Probability DSB is rejoined correctly

! TLK model inputs (simple and complex double strand breaks)
DSB = 20 5 / !Radiation damage to DNA
HT4R =5.9489839E-01 8.0047369E+00 / !Half-times for DSB repair
PML =1.1606471E-02 / !Probability a misrejoined DSB is lethal
PMR = 0.75 0.25 / !Probability DSB is rejoined correctly

! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10

! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09

RADX: ADR=RX1 AD=RX2
RX1 = 0.06 0.17 0.29 0.49 2.4 55 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 40 45 50 55 60 65 70 75 /

Last updated: 10 June, 2011
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