VC 2.00I 15-JUL-2003 01-AUG-2003 02:37:32 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\c3h.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\c3h.radx (7 exposures) XDAT: ..\xdat\c3h.xdat (7 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 1.4844235E-02 2202 CLRP RHT 1.00000E-02 2.40000E+01 2.00000E+00 2.5157519E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 5.33819E-03 (nfom=72, nsim=504, nmx=7, nox=7, ndf=4, nap=2) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-6.848E-02 max=5.063E-02, mean=-1.5798E-02, stdev=4.6910E-02, var=2.2005E-03 Student's T test (mean=0, NDF=4): Pr>ABS(0.89105)= 4.2326E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.90194)=3.568E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-1.167E-02 max=2.983E-02, mean=-1.3076E-03, stdev=1.5190E-02, var=2.3072E-04 Student's T test (mean=0, NDF=4): Pr>ABS(0.22776)= 8.3100E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.76040)=1.593E-02 (normality questionable) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 1.484424E-02 (=1.484%) PHI2= 1.484424E-02 (=1.484%) (1-A1)*PHI1= 3.711059E-03 (=0.371%) (1-A2)*PHI2= 1.113318E-02 (=1.113%) (1-A1)*(1-PHI1)= 2.462889E-01 (=24.629%) (1-A2)*(1-PHI2)= 7.388668E-01 (=73.887%) RHT1= 0.250000 h (=15.00 minute) RHT2= 2.515752 h (=150.95 minute) LAM1= 2.7725887E+00 (1/h) LAM2= 2.7552287E-01 (1/h) BMR= 2.7500000E-04 (1/h) LAM1/BMR= 1.0082141E+04 LAM2/BMR= 1.0019013E+03 (LAM1+LAM2)/BMR= 1.1084042E+04 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.1133E-01 + 1.1133E-01 = 2.2266353E-01 (1/Gy) beta: 1.7558E-02 + 1.8486E-02 = 3.6044579E-02 (1/Gy^2) alpha/beta: 6.1774483 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (C3H 10T1/2 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 2.0833E-02 2.5000E-01 1.2000E+01 9.70000E-01 1.68E-01 9.43752E-01 -2.7813E-02 2 4.1667E-02 5.0000E-01 1.2000E+01 8.50000E-01 5.17E-01 8.86802E-01 4.1500E-02 3 8.3333E-02 1.0000E+00 1.2000E+01 8.00000E-01 1.14E-01 7.73312E-01 -3.4511E-02 4 1.2500E-01 1.5000E+00 1.2000E+01 6.70000E-01 1.43E-01 6.63841E-01 -9.2782E-03 5 1.6667E-01 2.0000E+00 1.2000E+01 6.00000E-01 2.86E-02 5.61547E-01 -6.8476E-02 6 2.5000E-01 3.0000E+00 1.2000E+01 4.10000E-01 1.34E-02 3.85830E-01 -6.2645E-02 7 4.1667E-01 5.0000E+00 1.2000E+01 1.50000E-01 1.61E-02 1.58000E-01 5.0634E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-6.848E-02 max=5.063E-02, mean=-1.5798E-02, stdev=4.6910E-02, var=2.2005E-03 Student's T test (mean=0, NDF=4): Pr>ABS(0.89105)= 4.2326E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.90194)=3.568E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-1.167E-02 max=2.983E-02, mean=-1.3076E-03, stdev=1.5190E-02, var=2.3072E-04 Student's T test (mean=0, NDF=4): Pr>ABS(0.22776)= 8.3100E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.76040)=1.593E-02 (normality questionable) NOX=7, NPAR=2 CFE.SF: Cell survival data for C3H 10T1/2 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 2.0833E-02 2.5000E-01 1.2000E+01 3.00000E-02 9.70000E-01 4.12E-02 2 2 4.1667E-02 5.0000E-01 1.2000E+01 1.50000E-01 8.50000E-01 2.35E-02 3 3 8.3333E-02 1.0000E+00 1.2000E+01 2.00000E-01 8.00000E-01 5.00E-02 4 4 1.2500E-01 1.5000E+00 1.2000E+01 3.30000E-01 6.70000E-01 4.48E-02 5 5 1.6667E-01 2.0000E+00 1.2000E+01 4.00000E-01 6.00000E-01 1.00E-01 6 6 2.5000E-01 3.0000E+00 1.2000E+01 5.90000E-01 4.10000E-01 1.46E-01 7 7 4.1667E-01 5.0000E+00 1.2000E+01 8.50000E-01 1.50000E-01 1.33E-01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (C3H 10T1/2). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 2.083E-02 1.200E+01 4.000E+02 2.5000E-01 1.2184E-01 3.0459E-02 2 2 4.167E-02 1.200E+01 4.000E+02 5.0000E-01 3.2504E-01 1.6252E-01 3 3 8.333E-02 1.200E+01 4.000E+02 1.0000E+00 2.2314E-01 2.2314E-01 4 4 1.250E-01 1.200E+01 4.000E+02 1.5000E+00 2.6699E-01 4.0048E-01 5 5 1.667E-01 1.200E+01 4.000E+02 2.0000E+00 2.5541E-01 5.1083E-01 6 6 2.500E-01 1.200E+01 4.000E+02 3.0000E+00 2.9720E-01 8.9160E-01 7 7 4.167E-01 1.200E+01 4.000E+02 5.0000E+00 3.7942E-01 1.8971E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 4.71333E-02 VC 2.00I 15-JUL-2003 01-AUG-2003 02:37:35 PM