Calibrated Input File
(TLK) Human Bladder Carcinoma Cells |
/* Measured C3H 10T1/2 cell survival data from REFERENCE: AJ Mill, D Frankenberg, D Bettega, L Hieber, A Saran, LA Allen, P Calzolari, M Frankenberg-Schwager, et. al., Transformation of C3H 10T 1/2 cells by low doses of ionising radiation: a collaborative study by six European laboratories strongly supporting a linear dose response relationship. J. Radiol. Prot., 18(2), 79-100 (1998). PREPARED BY: JULIEN PARTOUCHE (julien@tamu.edu) DATE: 21-JUL-2003 */ MODEL: DRM=TLK CKM=QECK !Model Specification CELL: DNA=5.667D+09 NC=46 IRAD: CL=DSB !Radiation damage to DNA CLRP: RHT=HT4R BMR=2.75E-04 PHI=PML A0=PMR CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1 RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data ! TLK model inputs (simple and complex double strand breaks) DSB = 30 10 / !Radiation damage to DNA HT4R = 0.25 2.5157519E+00 / !Half-times for DSB repair PML = 1.4844235E-02 / !Probability a misrejoined DSB is lethal PMR = 0.75 0.25 / !Probability DSB is rejoined correctly ! Parameters that impact on solution accuracy SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10 ! Parameters that control the time steps and stopping criteria SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09 !IRRADIATION CONDITIONS (single fraction) RADX: ADR=RX1 AD=RX2 RX1 = 12 / !dose rate (Gy/h) RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 / |
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Last updated:
10 June, 2011
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