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Calibrated Input File (RMR)
Human Bladder Carcinoma Cells

/*
 Measured C3H 10T1/2 cell survival data from

REFERENCE:
  AJ Mill, D Frankenberg, D Bettega, L Hieber, A Saran, LA Allen,
  P Calzolari, M Frankenberg-Schwager, et. al., Transformation of
  C3H 10T 1/2 cells by low doses of ionising radiation: a
  collaborative study by six European laboratories strongly
  supporting a linear dose response relationship. J. Radiol.
  Prot., 18(2), 79-100 (1998).

 PREPARED BY: JULIEN PARTOUCHE (julien@tamu.edu)
 DATE: 21-JUL-2003
 REVISED: RD Stewart (01-AUG-2003)
 Used 2-parameter fit with RHT=2 instead of three parameter fit (RHT=12 h)

*/
   

MODEL: DRM=RMR CKM=QECK !Model Specification
CELL: DNA=5.667D+09 NC=46
IRAD: CL=25 !Radiation damage to DNA
CLRP: RHT=2.0 BMR=1.4157080E-04 PHI=9.1055012E-03 A0=0.00
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data

! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10

! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0E+00 RCUT=1.0D-09

!IRRADIATION CONDITIONS (single fraction)
RADX: ADR=RX1 AD=RX2
RX1 = 12 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 /


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