VC 2.00I 15-JUL-2003 01-AUG-2003 02:15:39 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\c3h\mi98\lpl\c3h.inp FNI: U:\archive\c3h\Mi98\lpl\c3h.inp FNO: U:\archive\c3h\Mi98\lpl\c3h.out RADX: U:\archive\c3h\Mi98\lpl\c3h.radx (22 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- LPLM TABLE: Summary of LPL parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 RADIATION DAMAGE: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 7.17785E-12 4.41151E-03 25.000000 FL = 6.53670E-14 4.01746E-05 0.227669 DAMAGE REPAIR/MISREPAIR: A0= 9.500000E-01 (=95.000%) (1-A0)= 5.000000E-02 (=5.000%) RHT= 2.000000 h (=120.00 minute) LAM= 3.4657359E-01 (1/h) BMR= 1.3624112E-04 (1/h) LAM/BMR= 2.5438252E+03 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 0.227669 (1/Gy) beta = 0.030712 (1/Gy^2) alpha/beta = 7.413131 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 8.333E-03 7.201E+01 1.000E-01 1.200E+01 3.066E-04 2.277E-02 2.3074E-02 9.771906E-01 3 2.083E-02 7.202E+01 2.500E-01 1.200E+01 1.912E-03 5.692E-02 5.8829E-02 9.428679E-01 4 4.167E-02 7.204E+01 5.000E-01 1.200E+01 7.616E-03 1.138E-01 1.2145E-01 8.856346E-01 5 8.333E-02 7.208E+01 1.000E+00 1.200E+01 3.022E-02 2.277E-01 2.5789E-01 7.726799E-01 6 1.250E-01 7.212E+01 1.500E+00 1.200E+01 6.746E-02 3.415E-01 4.0896E-01 6.643404E-01 7 1.667E-01 7.217E+01 2.000E+00 1.200E+01 1.190E-01 4.553E-01 5.7431E-01 5.630922E-01 8 2.500E-01 7.225E+01 3.000E+00 1.200E+01 2.635E-01 6.830E-01 9.4651E-01 3.880943E-01 9 3.333E-01 7.233E+01 4.000E+00 1.200E+01 4.612E-01 9.107E-01 1.3719E+00 2.536356E-01 10 4.167E-01 7.242E+01 5.000E+00 1.200E+01 7.095E-01 1.138E+00 1.8479E+00 1.575717E-01 11 5.000E-01 7.250E+01 6.000E+00 1.200E+01 1.006E+00 1.366E+00 2.3722E+00 9.327547E-02 12 5.833E-01 7.258E+01 7.000E+00 1.200E+01 1.349E+00 1.594E+00 2.9426E+00 5.272947E-02 13 6.667E-01 7.267E+01 8.000E+00 1.200E+01 1.736E+00 1.821E+00 3.5569E+00 2.852746E-02 14 7.500E-01 7.275E+01 9.000E+00 1.200E+01 2.164E+00 2.049E+00 4.2131E+00 1.480057E-02 15 8.333E-01 7.283E+01 1.000E+01 1.200E+01 2.633E+00 2.277E+00 4.9093E+00 7.377986E-03 16 1.042E+00 7.304E+01 1.250E+01 1.200E+01 3.967E+00 2.846E+00 6.8127E+00 1.099757E-03 17 1.250E+00 7.325E+01 1.500E+01 1.200E+01 5.513E+00 3.415E+00 8.9282E+00 1.325917E-04 18 1.458E+00 7.346E+01 1.750E+01 1.200E+01 7.248E+00 3.984E+00 1.1233E+01 1.323517E-05 19 1.667E+00 7.367E+01 2.000E+01 1.200E+01 9.152E+00 4.553E+00 1.3705E+01 1.116633E-06 20 2.083E+00 7.408E+01 2.500E+01 1.200E+01 1.339E+01 5.692E+00 1.9084E+01 5.153622E-09 21 2.500E+00 7.450E+01 3.000E+01 1.200E+01 1.811E+01 6.830E+00 2.4940E+01 1.474598E-11 22 2.917E+00 7.492E+01 3.500E+01 1.200E+01 2.321E+01 7.968E+00 3.1177E+01 2.883460E-14 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 3.000E+00 1.000E-01 1.200E+01 9.7719E-01 9.7719E-01 1.0000E+00 9.7719E-01 9.7719E-01 9.7719E-01 3 3.001E+00 2.500E-01 1.200E+01 9.4287E-01 9.4287E-01 1.0000E+00 9.4287E-01 9.4287E-01 9.4287E-01 4 3.002E+00 5.000E-01 1.200E+01 8.8563E-01 8.8563E-01 1.0000E+00 8.8563E-01 8.8563E-01 8.8563E-01 5 3.003E+00 1.000E+00 1.200E+01 7.7268E-01 7.7268E-01 1.0000E+00 7.7268E-01 7.7268E-01 7.7268E-01 6 3.005E+00 1.500E+00 1.200E+01 6.6434E-01 6.6434E-01 1.0000E+00 6.6434E-01 6.6434E-01 6.6434E-01 7 3.007E+00 2.000E+00 1.200E+01 5.6309E-01 5.6309E-01 1.0000E+00 5.6309E-01 5.6309E-01 5.6309E-01 8 3.010E+00 3.000E+00 1.200E+01 3.8809E-01 3.8809E-01 1.0000E+00 3.8809E-01 3.8809E-01 3.8809E-01 9 3.014E+00 4.000E+00 1.200E+01 2.5364E-01 2.5364E-01 1.0000E+00 2.5364E-01 2.5364E-01 2.5364E-01 10 3.017E+00 5.000E+00 1.200E+01 1.5757E-01 1.5757E-01 1.0000E+00 1.5757E-01 1.5757E-01 1.5757E-01 11 3.021E+00 6.000E+00 1.200E+01 9.3275E-02 9.3275E-02 1.0000E+00 9.3275E-02 9.3275E-02 9.3275E-02 12 3.024E+00 7.000E+00 1.200E+01 5.2729E-02 5.2729E-02 1.0000E+00 5.2729E-02 5.2729E-02 5.2729E-02 13 3.028E+00 8.000E+00 1.200E+01 2.8527E-02 2.8527E-02 1.0000E+00 2.8527E-02 2.8527E-02 2.8527E-02 14 3.031E+00 9.000E+00 1.200E+01 1.4801E-02 1.4801E-02 1.0000E+00 1.4801E-02 1.4801E-02 1.4801E-02 15 3.035E+00 1.000E+01 1.200E+01 7.3780E-03 7.3780E-03 1.0000E+00 7.3780E-03 7.3780E-03 7.3780E-03 16 3.043E+00 1.250E+01 1.200E+01 1.0998E-03 1.0998E-03 1.0000E+00 1.0998E-03 1.0998E-03 1.0998E-03 17 3.052E+00 1.500E+01 1.200E+01 1.3259E-04 1.3259E-04 1.0000E+00 1.3259E-04 1.3259E-04 1.3259E-04 18 3.061E+00 1.750E+01 1.200E+01 1.3235E-05 1.3235E-05 1.0000E+00 1.3235E-05 1.3235E-05 1.3235E-05 19 3.069E+00 2.000E+01 1.200E+01 1.1166E-06 1.1166E-06 1.0000E+00 1.1166E-06 1.1166E-06 1.1166E-06 20 3.087E+00 2.500E+01 1.200E+01 5.1536E-09 5.1536E-09 1.0000E+00 5.1536E-09 5.1536E-09 5.1536E-09 21 3.104E+00 3.000E+01 1.200E+01 1.4746E-11 1.4746E-11 1.0000E+00 1.4746E-11 1.4746E-11 1.4746E-11 22 3.122E+00 3.500E+01 1.200E+01 2.8835E-14 2.8835E-14 1.0000E+00 2.8835E-14 2.8835E-14 2.8835E-14 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 1.200E+01 1.259E-01 0.00E+00 1.25859E-01 5.227E-07 5.227E-07 5.349E-07 3 2.500E-01 1.200E+01 3.179E-01 0.00E+00 3.17853E-01 1.274E-06 1.274E-06 1.351E-06 4 5.000E-01 1.200E+01 6.463E-01 0.00E+00 6.46325E-01 2.433E-06 2.433E-06 2.747E-06 5 1.000E+00 1.200E+01 1.335E+00 0.00E+00 1.33462E+00 4.383E-06 4.383E-06 5.672E-06 6 1.500E+00 1.200E+01 2.064E+00 0.00E+00 2.06388E+00 5.827E-06 5.827E-06 8.771E-06 7 2.000E+00 1.200E+01 2.833E+00 0.00E+00 2.83313E+00 6.780E-06 6.780E-06 1.204E-05 8 3.000E+00 1.200E+01 4.488E+00 0.00E+00 4.48780E+00 7.402E-06 7.402E-06 1.907E-05 9 4.000E+00 1.200E+01 6.291E+00 0.00E+00 6.29130E+00 6.782E-06 6.782E-06 2.674E-05 10 5.000E+00 1.200E+01 8.237E+00 0.00E+00 8.23668E+00 5.516E-06 5.516E-06 3.501E-05 11 6.000E+00 1.200E+01 1.032E+01 0.00E+00 1.03173E+01 4.090E-06 4.090E-06 4.385E-05 12 7.000E+00 1.200E+01 1.253E+01 0.00E+00 1.25269E+01 2.807E-06 2.807E-06 5.324E-05 13 8.000E+00 1.200E+01 1.486E+01 0.00E+00 1.48595E+01 1.802E-06 1.802E-06 6.315E-05 14 9.000E+00 1.200E+01 1.731E+01 0.00E+00 1.73094E+01 1.089E-06 1.089E-06 7.356E-05 15 1.000E+01 1.200E+01 1.987E+01 0.00E+00 1.98712E+01 6.231E-07 6.231E-07 8.445E-05 16 1.250E+01 1.200E+01 2.673E+01 0.00E+00 2.67320E+01 1.249E-07 1.249E-07 1.136E-04 17 1.500E+01 1.200E+01 3.419E+01 0.00E+00 3.41870E+01 1.926E-08 1.926E-08 1.453E-04 18 1.750E+01 1.200E+01 4.217E+01 0.00E+00 4.21706E+01 2.372E-09 2.372E-09 1.792E-04 19 2.000E+01 1.200E+01 5.063E+01 0.00E+00 5.06251E+01 2.402E-10 2.402E-10 2.151E-04 20 2.500E+01 1.200E+01 6.875E+01 0.00E+00 6.87471E+01 1.506E-12 1.506E-12 2.921E-04 21 3.000E+01 1.200E+01 8.821E+01 0.00E+00 8.82079E+01 5.527E-15 5.527E-15 3.748E-04 22 3.500E+01 1.200E+01 1.087E+02 0.00E+00 1.08735E+02 1.332E-17 1.332E-17 4.620E-04 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 1.200E+01 1.259E-01 5.227E-07 5.349E-07 6.8995E-05 6.9002E-05 6.7428E-05 3 2.500E-01 1.200E+01 3.179E-01 1.274E-06 1.351E-06 6.8995E-05 6.9011E-05 6.5068E-05 4 5.000E-01 1.200E+01 6.463E-01 2.433E-06 2.747E-06 6.8995E-05 6.9028E-05 6.1133E-05 5 1.000E+00 1.200E+01 1.335E+00 4.383E-06 5.672E-06 6.8995E-05 6.9062E-05 5.3363E-05 6 1.500E+00 1.200E+01 2.064E+00 5.827E-06 8.771E-06 6.8995E-05 6.9099E-05 4.5905E-05 7 2.000E+00 1.200E+01 2.833E+00 6.780E-06 1.204E-05 6.8994E-05 6.9138E-05 3.8931E-05 8 3.000E+00 1.200E+01 4.488E+00 7.402E-06 1.907E-05 6.8994E-05 6.9221E-05 2.6864E-05 9 4.000E+00 1.200E+01 6.291E+00 6.782E-06 2.674E-05 6.8993E-05 6.9312E-05 1.7580E-05 10 5.000E+00 1.200E+01 8.237E+00 5.516E-06 3.501E-05 6.8993E-05 6.9410E-05 1.0937E-05 11 6.000E+00 1.200E+01 1.032E+01 4.090E-06 4.385E-05 6.8992E-05 6.9515E-05 6.4841E-06 12 7.000E+00 1.200E+01 1.253E+01 2.807E-06 5.324E-05 6.8992E-05 6.9627E-05 3.6714E-06 13 8.000E+00 1.200E+01 1.486E+01 1.802E-06 6.315E-05 6.8991E-05 6.9744E-05 1.9896E-06 14 9.000E+00 1.200E+01 1.731E+01 1.089E-06 7.356E-05 6.8990E-05 6.9868E-05 1.0341E-06 15 1.000E+01 1.200E+01 1.987E+01 6.231E-07 8.445E-05 6.8989E-05 6.9997E-05 5.1643E-07 16 1.250E+01 1.200E+01 2.673E+01 1.249E-07 1.136E-04 6.8987E-05 7.0342E-05 7.7360E-08 17 1.500E+01 1.200E+01 3.419E+01 1.926E-08 1.453E-04 6.8985E-05 7.0718E-05 9.3766E-09 18 1.750E+01 1.200E+01 4.217E+01 2.372E-09 1.792E-04 6.8983E-05 7.1121E-05 9.4129E-10 19 2.000E+01 1.200E+01 5.063E+01 2.402E-10 2.151E-04 6.8980E-05 7.1547E-05 7.9891E-11 20 2.500E+01 1.200E+01 6.875E+01 1.506E-12 2.921E-04 6.8975E-05 7.2460E-05 3.7343E-13 21 3.000E+01 1.200E+01 8.821E+01 5.527E-15 3.748E-04 6.8969E-05 7.3440E-05 1.0829E-15 22 3.500E+01 1.200E+01 1.087E+02 1.332E-17 4.620E-04 6.8963E-05 7.4474E-05 2.1474E-18 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency LPLM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.228 (1/Gy), alpha/beta = 7.413 (Gy), lamda = 3.466E-01 (1/h). ====================================================================================================== --- Duration (h) --- Dose Dose Rate* ***** G FACTOR ***** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL GEFF SF1 SF2 ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 8.333E-03 7.201E+01 1.000E-01 1.200E+01 9.990E-01 9.984E-01 9.7719E-01 9.771906E-01 3 2.083E-02 7.202E+01 2.500E-01 1.200E+01 9.976E-01 9.960E-01 9.4286E-01 9.428679E-01 4 4.167E-02 7.204E+01 5.000E-01 1.200E+01 9.952E-01 9.920E-01 8.8561E-01 8.856346E-01 5 8.333E-02 7.208E+01 1.000E+00 1.200E+01 9.904E-01 9.840E-01 7.7253E-01 7.726799E-01 6 1.250E-01 7.212E+01 1.500E+00 1.200E+01 9.857E-01 9.762E-01 6.6390E-01 6.643404E-01 7 1.667E-01 7.217E+01 2.000E+00 1.200E+01 9.810E-01 9.685E-01 5.6222E-01 5.630922E-01 8 2.500E-01 7.225E+01 3.000E+00 1.200E+01 9.717E-01 9.533E-01 3.8612E-01 3.880943E-01 9 3.333E-01 7.233E+01 4.000E+00 1.200E+01 9.626E-01 9.385E-01 2.5066E-01 2.536356E-01 10 4.167E-01 7.242E+01 5.000E+00 1.200E+01 9.536E-01 9.241E-01 1.5405E-01 1.575717E-01 11 5.000E-01 7.250E+01 6.000E+00 1.200E+01 9.447E-01 9.101E-01 8.9775E-02 9.327547E-02 12 5.833E-01 7.258E+01 7.000E+00 1.200E+01 9.359E-01 8.964E-01 4.9684E-02 5.272947E-02 13 6.667E-01 7.267E+01 8.000E+00 1.200E+01 9.272E-01 8.830E-01 2.6151E-02 2.852746E-02 14 7.500E-01 7.275E+01 9.000E+00 1.200E+01 9.187E-01 8.699E-01 1.3109E-02 1.480057E-02 15 8.333E-01 7.283E+01 1.000E+01 1.200E+01 9.103E-01 8.572E-01 6.2676E-03 7.377986E-03 16 1.042E+00 7.304E+01 1.250E+01 1.200E+01 8.898E-01 8.266E-01 8.1228E-04 1.099757E-03 17 1.250E+00 7.325E+01 1.500E+01 1.200E+01 8.700E-01 7.978E-01 8.0549E-05 1.325917E-04 18 1.458E+00 7.346E+01 1.750E+01 1.200E+01 8.508E-01 7.707E-01 6.2268E-06 1.323517E-05 19 1.667E+00 7.367E+01 2.000E+01 1.200E+01 8.323E-01 7.450E-01 3.8181E-07 1.116633E-06 20 2.083E+00 7.408E+01 2.500E+01 1.200E+01 7.972E-01 6.977E-01 7.6330E-10 5.153622E-09 21 2.500E+00 7.450E+01 3.000E+01 1.200E+01 7.643E-01 6.552E-01 7.2282E-13 1.474598E-11 22 2.917E+00 7.492E+01 3.500E+01 1.200E+01 7.335E-01 6.169E-01 3.5849E-16 2.883460E-14 ------------------------------------------------------------------------------------------------------ GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/D)/(beta*D). In the formula for GEFF, SF is surviving fraction as computed using the LPL model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL. The SF estimates are: SF1=EXP{-dose*[alpha+gl*beta*dose]} and SF2=EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 3.000E+00 1.000E-01 9.7719E-01 9.7719E-01 9.7719E-01 3.7637E-01 3.7637E-01 3.7637E-01 3.7637E-01 3 3.001E+00 2.500E-01 9.4287E-01 9.4287E-01 9.4287E-01 3.8951E-01 3.8951E-01 3.8951E-01 3.8951E-01 4 3.002E+00 5.000E-01 8.8563E-01 8.8563E-01 8.8563E-01 4.1245E-01 4.1245E-01 4.1245E-01 4.1245E-01 5 3.003E+00 1.000E+00 7.7268E-01 7.7268E-01 7.7268E-01 4.6177E-01 4.6177E-01 4.6177E-01 4.6177E-01 6 3.005E+00 1.500E+00 6.6434E-01 6.6434E-01 6.6434E-01 5.1461E-01 5.1461E-01 5.1461E-01 5.1461E-01 7 3.007E+00 2.000E+00 5.6309E-01 5.6309E-01 5.6309E-01 5.6945E-01 5.6945E-01 5.6945E-01 5.6945E-01 8 3.010E+00 3.000E+00 3.8809E-01 3.8809E-01 3.8809E-01 6.7835E-01 6.7835E-01 6.7835E-01 6.7835E-01 9 3.014E+00 4.000E+00 2.5364E-01 2.5364E-01 2.5364E-01 7.7597E-01 7.7597E-01 7.7597E-01 7.7597E-01 10 3.017E+00 5.000E+00 1.5757E-01 1.5757E-01 1.5757E-01 8.5422E-01 8.5422E-01 8.5422E-01 8.5422E-01 11 3.021E+00 6.000E+00 9.3275E-02 9.3275E-02 9.3275E-02 9.1094E-01 9.1094E-01 9.1094E-01 9.1094E-01 12 3.024E+00 7.000E+00 5.2729E-02 5.2729E-02 5.2729E-02 9.4864E-01 9.4864E-01 9.4864E-01 9.4864E-01 13 3.028E+00 8.000E+00 2.8527E-02 2.8527E-02 2.8527E-02 9.7188E-01 9.7188E-01 9.7188E-01 9.7188E-01 14 3.031E+00 9.000E+00 1.4801E-02 1.4801E-02 1.4801E-02 9.8531E-01 9.8531E-01 9.8531E-01 9.8531E-01 15 3.035E+00 1.000E+01 7.3780E-03 7.3780E-03 7.3780E-03 9.9265E-01 9.9265E-01 9.9265E-01 9.9265E-01 16 3.043E+00 1.250E+01 1.0998E-03 1.0998E-03 1.0998E-03 9.9890E-01 9.9890E-01 9.9890E-01 9.9890E-01 17 3.052E+00 1.500E+01 1.3259E-04 1.3259E-04 1.3259E-04 9.9987E-01 9.9987E-01 9.9987E-01 9.9987E-01 18 3.061E+00 1.750E+01 1.3235E-05 1.3235E-05 1.3235E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 19 3.069E+00 2.000E+01 1.1166E-06 1.1166E-06 1.1166E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 20 3.087E+00 2.500E+01 5.1536E-09 5.1536E-09 5.1536E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 3.104E+00 3.000E+01 1.4746E-11 1.4746E-11 1.4746E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 3.122E+00 3.500E+01 2.8835E-14 2.8835E-14 2.8835E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 8.333E-03 3.472E-04 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+01 3 2.083E-02 8.681E-04 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+01 4 4.167E-02 1.736E-03 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+01 5 8.333E-02 3.472E-03 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+01 6 1.250E-01 5.208E-03 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+01 7 1.667E-01 6.944E-03 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+01 8 2.500E-01 1.042E-02 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+01 9 3.333E-01 1.389E-02 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+01 10 4.167E-01 1.736E-02 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+01 11 5.000E-01 2.083E-02 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+01 12 5.833E-01 2.431E-02 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+01 13 6.667E-01 2.778E-02 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+01 14 7.500E-01 3.125E-02 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+01 15 8.333E-01 3.472E-02 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+01 16 1.042E+00 4.340E-02 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+01 17 1.250E+00 5.208E-02 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+01 18 1.458E+00 6.076E-02 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+01 19 1.667E+00 6.944E-02 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+01 20 2.083E+00 8.681E-02 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+01 21 2.500E+00 1.042E-01 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+01 22 2.917E+00 1.215E-01 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 2.60000E-03 VC 2.00I 15-JUL-2003 01-AUG-2003 02:15:40 PM