VC 2.00I 15-JUL-2003 02-AUG-2003 03:02:14 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\hx118\tlk\hx118.inp FNI: U:\archive\hx118\tlk\hx118.inp FNO: U:\archive\hx118\tlk\hx118.out RADX: U:\archive\hx118\tlk\hx118.radx (66 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 5.74228E-12 3.52920E-03 20.000000 Complex DSB = 1.43557E-12 8.82301E-04 5.000000 Total DSB = 7.17785E-12 4.41151E-03 25.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 3.429933E-02 (=3.430%) PHI2= 3.429933E-02 (=3.430%) (1-A1)*PHI1= 8.574833E-03 (=0.857%) (1-A2)*PHI2= 2.572450E-02 (=2.572%) (1-A1)*(1-PHI1)= 2.414252E-01 (=24.143%) (1-A2)*(1-PHI2)= 7.242755E-01 (=72.428%) RHT1= 0.031814 h (=1.91 minute) RHT2= 0.591944 h (=35.52 minute) LAM1= 2.1787429E+01 (1/h) LAM2= 1.1709674E+00 (1/h) BMR= 8.2597109E-03 (1/h) LAM1/BMR= 2.6377956E+03 LAM2/BMR= 1.4176857E+02 (LAM1+LAM2)/BMR= 2.7795642E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.7150E-01 + 1.2862E-01 = 3.0011915E-01 (1/Gy) beta: 2.6682E-02 + 2.8152E-02 = 5.4834310E-02 (1/Gy^2) alpha/beta: 5.4732002 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 1.042E-01 3.610E+01 1.000E-01 9.600E-01 3.042E-02 0.000E+00 3.0424E-02 9.700344E-01 3 2.604E-01 3.626E+01 2.500E-01 9.600E-01 7.710E-02 1.964E-29 7.7098E-02 9.257993E-01 4 5.208E-01 3.652E+01 5.000E-01 9.600E-01 1.569E-01 0.000E+00 1.5687E-01 8.548173E-01 5 1.042E+00 3.704E+01 1.000E+00 9.600E-01 3.215E-01 0.000E+00 3.2148E-01 7.250784E-01 6 1.562E+00 3.756E+01 1.500E+00 9.600E-01 4.901E-01 0.000E+00 4.9009E-01 6.125739E-01 7 2.083E+00 3.808E+01 2.000E+00 9.600E-01 6.608E-01 0.000E+00 6.6079E-01 5.164425E-01 8 3.125E+00 3.912E+01 3.000E+00 9.600E-01 1.005E+00 2.333E-42 1.0050E+00 3.660553E-01 9 4.167E+00 4.017E+01 4.000E+00 9.600E-01 1.350E+00 0.000E+00 1.3505E+00 2.591152E-01 10 5.208E+00 4.121E+01 5.000E+00 9.600E-01 1.696E+00 0.000E+00 1.6964E+00 1.833499E-01 11 6.250E+00 4.225E+01 6.000E+00 9.600E-01 2.042E+00 0.000E+00 2.0423E+00 1.297254E-01 12 7.292E+00 4.329E+01 7.000E+00 9.600E-01 2.388E+00 0.000E+00 2.3883E+00 9.178201E-02 13 8.333E+00 4.433E+01 8.000E+00 9.600E-01 2.734E+00 0.000E+00 2.7344E+00 6.493620E-02 14 9.375E+00 4.538E+01 9.000E+00 9.600E-01 3.080E+00 0.000E+00 3.0804E+00 4.594257E-02 15 1.042E+01 4.642E+01 1.000E+01 9.600E-01 3.426E+00 0.000E+00 3.4264E+00 3.250450E-02 16 1.302E+01 4.902E+01 1.250E+01 9.600E-01 4.291E+00 0.000E+00 4.2914E+00 1.368559E-02 17 1.562E+01 5.162E+01 1.500E+01 9.600E-01 5.156E+00 0.000E+00 5.1564E+00 5.762140E-03 18 1.823E+01 5.423E+01 1.750E+01 9.600E-01 6.021E+00 2.414E-30 6.0215E+00 2.426074E-03 19 2.083E+01 5.683E+01 2.000E+01 9.600E-01 6.887E+00 0.000E+00 6.8865E+00 1.021467E-03 20 2.604E+01 6.204E+01 2.500E+01 9.600E-01 8.617E+00 0.000E+00 8.6166E+00 1.810775E-04 21 3.125E+01 6.725E+01 3.000E+01 9.600E-01 1.035E+01 0.000E+00 1.0347E+01 3.209999E-05 22 3.646E+01 7.246E+01 3.500E+01 9.600E-01 1.208E+01 0.000E+00 1.2077E+01 5.690432E-06 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 2.193E-02 3.602E+01 1.000E-01 4.560E+00 3.052E-02 0.000E+00 3.0519E-02 9.699420E-01 25 5.482E-02 3.605E+01 2.500E-01 4.560E+00 7.790E-02 0.000E+00 7.7901E-02 9.250559E-01 26 1.096E-01 3.611E+01 5.000E-01 4.560E+00 1.602E-01 0.000E+00 1.6017E-01 8.519991E-01 27 2.193E-01 3.622E+01 1.000E+00 4.560E+00 3.342E-01 3.009E-30 3.3420E-01 7.159101E-01 28 3.289E-01 3.633E+01 1.500E+00 4.560E+00 5.186E-01 0.000E+00 5.1855E-01 5.953810E-01 29 4.386E-01 3.644E+01 2.000E+00 4.560E+00 7.115E-01 0.000E+00 7.1155E-01 4.908834E-01 30 6.579E-01 3.666E+01 3.000E+00 4.560E+00 1.118E+00 1.336E-31 1.1184E+00 3.267892E-01 31 8.772E-01 3.688E+01 4.000E+00 4.560E+00 1.547E+00 1.437E-12 1.5467E+00 2.129572E-01 32 1.096E+00 3.710E+01 5.000E+00 4.560E+00 1.990E+00 0.000E+00 1.9903E+00 1.366542E-01 33 1.316E+00 3.732E+01 6.000E+00 4.560E+00 2.445E+00 0.000E+00 2.4451E+00 8.671980E-02 34 1.535E+00 3.754E+01 7.000E+00 4.560E+00 2.908E+00 0.000E+00 2.9079E+00 5.459092E-02 35 1.754E+00 3.775E+01 8.000E+00 4.560E+00 3.377E+00 0.000E+00 3.3765E+00 3.416644E-02 36 1.974E+00 3.797E+01 9.000E+00 4.560E+00 3.849E+00 0.000E+00 3.8493E+00 2.129399E-02 37 2.193E+00 3.819E+01 1.000E+01 4.560E+00 4.325E+00 0.000E+00 4.3252E+00 1.323117E-02 38 2.741E+00 3.874E+01 1.250E+01 4.560E+00 5.523E+00 0.000E+00 5.5231E+00 3.993479E-03 39 3.289E+00 3.929E+01 1.500E+01 4.560E+00 6.727E+00 0.000E+00 6.7274E+00 1.197702E-03 40 3.838E+00 3.984E+01 1.750E+01 4.560E+00 7.934E+00 0.000E+00 7.9344E+00 3.581999E-04 41 4.386E+00 4.039E+01 2.000E+01 4.560E+00 9.143E+00 0.000E+00 9.1427E+00 1.069944E-04 42 5.482E+00 4.148E+01 2.500E+01 4.560E+00 1.156E+01 0.000E+00 1.1561E+01 9.533378E-06 43 6.579E+00 4.258E+01 3.000E+01 4.560E+00 1.398E+01 0.000E+00 1.3979E+01 8.490075E-07 44 7.675E+00 4.368E+01 3.500E+01 4.560E+00 1.640E+01 0.000E+00 1.6398E+01 7.560193E-08 45 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 46 1.111E-03 3.600E+01 1.000E-01 9.000E+01 3.056E-02 0.000E+00 3.0557E-02 9.699052E-01 47 2.778E-03 3.600E+01 2.500E-01 9.000E+01 7.841E-02 0.000E+00 7.8406E-02 9.245891E-01 48 5.556E-03 3.601E+01 5.000E-01 9.000E+01 1.634E-01 0.000E+00 1.6337E-01 8.492806E-01 49 1.111E-02 3.601E+01 1.000E+00 9.000E+01 3.518E-01 1.696E-36 3.5183E-01 7.034024E-01 50 1.667E-02 3.602E+01 1.500E+00 9.000E+01 5.633E-01 5.042E-30 5.6330E-01 5.693277E-01 51 2.222E-02 3.602E+01 2.000E+00 9.000E+01 7.959E-01 1.001E-11 7.9593E-01 4.511599E-01 52 3.333E-02 3.603E+01 3.000E+00 9.000E+01 1.318E+00 0.000E+00 1.3183E+00 2.675976E-01 53 4.444E-02 3.604E+01 4.000E+00 9.000E+01 1.908E+00 0.000E+00 1.9077E+00 1.484275E-01 54 5.556E-02 3.606E+01 5.000E+00 9.000E+01 2.555E+00 4.703E-29 2.5551E+00 7.768199E-02 55 6.667E-02 3.607E+01 6.000E+00 9.000E+01 3.253E+00 5.011E-28 3.2534E+00 3.864105E-02 56 7.778E-02 3.608E+01 7.000E+00 9.000E+01 3.997E+00 7.417E-12 3.9967E+00 1.837672E-02 57 8.889E-02 3.609E+01 8.000E+00 9.000E+01 4.780E+00 9.372E-12 4.7800E+00 8.396368E-03 58 1.000E-01 3.610E+01 9.000E+00 9.000E+01 5.599E+00 0.000E+00 5.5993E+00 3.700636E-03 59 1.111E-01 3.611E+01 1.000E+01 9.000E+01 6.451E+00 0.000E+00 6.4512E+00 1.578691E-03 60 1.389E-01 3.614E+01 1.250E+01 9.000E+01 8.706E+00 1.364E-41 8.7057E+00 1.656336E-04 61 1.667E-01 3.617E+01 1.500E+01 9.000E+01 1.111E+01 1.870E-12 1.1112E+01 1.493031E-05 62 1.944E-01 3.619E+01 1.750E+01 9.000E+01 1.365E+01 0.000E+00 1.3645E+01 1.185779E-06 63 2.222E-01 3.622E+01 2.000E+01 9.000E+01 1.629E+01 1.444E-12 1.6286E+01 8.457122E-08 64 2.778E-01 3.628E+01 2.500E+01 9.000E+01 2.183E+01 0.000E+00 2.1832E+01 3.299089E-10 65 3.333E-01 3.633E+01 3.000E+01 9.000E+01 2.766E+01 3.416E-12 2.7661E+01 9.707514E-13 66 3.889E-01 3.639E+01 3.500E+01 9.000E+01 3.371E+01 0.000E+00 3.3706E+01 2.299051E-15 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 1.504E+00 1.000E-01 9.600E-01 9.7003E-01 9.7003E-01 1.0000E+00 9.7003E-01 9.7003E-01 9.7003E-01 3 1.511E+00 2.500E-01 9.600E-01 9.2580E-01 9.2580E-01 1.0000E+00 9.2580E-01 9.2580E-01 9.2580E-01 4 1.522E+00 5.000E-01 9.600E-01 8.5482E-01 8.5482E-01 1.0000E+00 8.5482E-01 8.5482E-01 8.5482E-01 5 1.543E+00 1.000E+00 9.600E-01 7.2508E-01 7.2508E-01 1.0000E+00 7.2508E-01 7.2508E-01 7.2508E-01 6 1.565E+00 1.500E+00 9.600E-01 6.1257E-01 6.1257E-01 1.0000E+00 6.1257E-01 6.1257E-01 6.1257E-01 7 1.587E+00 2.000E+00 9.600E-01 5.1644E-01 5.1644E-01 1.0000E+00 5.1644E-01 5.1644E-01 5.1644E-01 8 1.630E+00 3.000E+00 9.600E-01 3.6606E-01 3.6606E-01 1.0000E+00 3.6606E-01 3.6606E-01 3.6606E-01 9 1.674E+00 4.000E+00 9.600E-01 2.5912E-01 2.5912E-01 1.0000E+00 2.5912E-01 2.5912E-01 2.5912E-01 10 1.717E+00 5.000E+00 9.600E-01 1.8335E-01 1.8335E-01 1.0000E+00 1.8335E-01 1.8335E-01 1.8335E-01 11 1.760E+00 6.000E+00 9.600E-01 1.2973E-01 1.2973E-01 1.0000E+00 1.2973E-01 1.2973E-01 1.2973E-01 12 1.804E+00 7.000E+00 9.600E-01 9.1782E-02 9.1782E-02 1.0000E+00 9.1782E-02 9.1782E-02 9.1782E-02 13 1.847E+00 8.000E+00 9.600E-01 6.4936E-02 6.4936E-02 1.0000E+00 6.4936E-02 6.4936E-02 6.4936E-02 14 1.891E+00 9.000E+00 9.600E-01 4.5943E-02 4.5943E-02 1.0000E+00 4.5943E-02 4.5943E-02 4.5943E-02 15 1.934E+00 1.000E+01 9.600E-01 3.2504E-02 3.2504E-02 1.0000E+00 3.2504E-02 3.2504E-02 3.2504E-02 16 2.043E+00 1.250E+01 9.600E-01 1.3686E-02 1.3686E-02 1.0000E+00 1.3686E-02 1.3686E-02 1.3686E-02 17 2.151E+00 1.500E+01 9.600E-01 5.7621E-03 5.7621E-03 1.0000E+00 5.7621E-03 5.7621E-03 5.7621E-03 18 2.260E+00 1.750E+01 9.600E-01 2.4261E-03 2.4261E-03 1.0000E+00 2.4261E-03 2.4261E-03 2.4261E-03 19 2.368E+00 2.000E+01 9.600E-01 1.0215E-03 1.0215E-03 1.0000E+00 1.0215E-03 1.0215E-03 1.0215E-03 20 2.585E+00 2.500E+01 9.600E-01 1.8108E-04 1.8108E-04 1.0000E+00 1.8108E-04 1.8108E-04 1.8108E-04 21 2.802E+00 3.000E+01 9.600E-01 3.2100E-05 3.2100E-05 1.0000E+00 3.2100E-05 3.2100E-05 3.2100E-05 22 3.019E+00 3.500E+01 9.600E-01 5.6904E-06 5.6904E-06 1.0000E+00 5.6904E-06 5.6904E-06 5.6904E-06 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 1.501E+00 1.000E-01 4.560E+00 9.6994E-01 9.6994E-01 1.0000E+00 9.6994E-01 9.6994E-01 9.6994E-01 25 1.502E+00 2.500E-01 4.560E+00 9.2506E-01 9.2506E-01 1.0000E+00 9.2506E-01 9.2506E-01 9.2506E-01 26 1.505E+00 5.000E-01 4.560E+00 8.5200E-01 8.5200E-01 1.0000E+00 8.5200E-01 8.5200E-01 8.5200E-01 27 1.509E+00 1.000E+00 4.560E+00 7.1591E-01 7.1591E-01 1.0000E+00 7.1591E-01 7.1591E-01 7.1591E-01 28 1.514E+00 1.500E+00 4.560E+00 5.9538E-01 5.9538E-01 1.0000E+00 5.9538E-01 5.9538E-01 5.9538E-01 29 1.518E+00 2.000E+00 4.560E+00 4.9088E-01 4.9088E-01 1.0000E+00 4.9088E-01 4.9088E-01 4.9088E-01 30 1.527E+00 3.000E+00 4.560E+00 3.2679E-01 3.2679E-01 1.0000E+00 3.2679E-01 3.2679E-01 3.2679E-01 31 1.537E+00 4.000E+00 4.560E+00 2.1296E-01 2.1296E-01 1.0000E+00 2.1296E-01 2.1296E-01 2.1296E-01 32 1.546E+00 5.000E+00 4.560E+00 1.3665E-01 1.3665E-01 1.0000E+00 1.3665E-01 1.3665E-01 1.3665E-01 33 1.555E+00 6.000E+00 4.560E+00 8.6720E-02 8.6720E-02 1.0000E+00 8.6720E-02 8.6720E-02 8.6720E-02 34 1.564E+00 7.000E+00 4.560E+00 5.4591E-02 5.4591E-02 1.0000E+00 5.4591E-02 5.4591E-02 5.4591E-02 35 1.573E+00 8.000E+00 4.560E+00 3.4166E-02 3.4166E-02 1.0000E+00 3.4166E-02 3.4166E-02 3.4166E-02 36 1.582E+00 9.000E+00 4.560E+00 2.1294E-02 2.1294E-02 1.0000E+00 2.1294E-02 2.1294E-02 2.1294E-02 37 1.591E+00 1.000E+01 4.560E+00 1.3231E-02 1.3231E-02 1.0000E+00 1.3231E-02 1.3231E-02 1.3231E-02 38 1.614E+00 1.250E+01 4.560E+00 3.9935E-03 3.9935E-03 1.0000E+00 3.9935E-03 3.9935E-03 3.9935E-03 39 1.637E+00 1.500E+01 4.560E+00 1.1977E-03 1.1977E-03 1.0000E+00 1.1977E-03 1.1977E-03 1.1977E-03 40 1.660E+00 1.750E+01 4.560E+00 3.5820E-04 3.5820E-04 1.0000E+00 3.5820E-04 3.5820E-04 3.5820E-04 41 1.683E+00 2.000E+01 4.560E+00 1.0699E-04 1.0699E-04 1.0000E+00 1.0699E-04 1.0699E-04 1.0699E-04 42 1.728E+00 2.500E+01 4.560E+00 9.5334E-06 9.5334E-06 1.0000E+00 9.5334E-06 9.5334E-06 9.5334E-06 43 1.774E+00 3.000E+01 4.560E+00 8.4901E-07 8.4901E-07 1.0000E+00 8.4901E-07 8.4901E-07 8.4901E-07 44 1.820E+00 3.500E+01 4.560E+00 7.5602E-08 7.5602E-08 1.0000E+00 7.5602E-08 7.5602E-08 7.5602E-08 45 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 46 1.500E+00 1.000E-01 9.000E+01 9.6991E-01 9.6991E-01 1.0000E+00 9.6991E-01 9.6991E-01 9.6991E-01 47 1.500E+00 2.500E-01 9.000E+01 9.2459E-01 9.2459E-01 1.0000E+00 9.2459E-01 9.2459E-01 9.2459E-01 48 1.500E+00 5.000E-01 9.000E+01 8.4928E-01 8.4928E-01 1.0000E+00 8.4928E-01 8.4928E-01 8.4928E-01 49 1.500E+00 1.000E+00 9.000E+01 7.0340E-01 7.0340E-01 1.0000E+00 7.0340E-01 7.0340E-01 7.0340E-01 50 1.501E+00 1.500E+00 9.000E+01 5.6933E-01 5.6933E-01 1.0000E+00 5.6933E-01 5.6933E-01 5.6933E-01 51 1.501E+00 2.000E+00 9.000E+01 4.5116E-01 4.5116E-01 1.0000E+00 4.5116E-01 4.5116E-01 4.5116E-01 52 1.501E+00 3.000E+00 9.000E+01 2.6760E-01 2.6760E-01 1.0000E+00 2.6760E-01 2.6760E-01 2.6760E-01 53 1.502E+00 4.000E+00 9.000E+01 1.4843E-01 1.4843E-01 1.0000E+00 1.4843E-01 1.4843E-01 1.4843E-01 54 1.502E+00 5.000E+00 9.000E+01 7.7682E-02 7.7682E-02 1.0000E+00 7.7682E-02 7.7682E-02 7.7682E-02 55 1.503E+00 6.000E+00 9.000E+01 3.8641E-02 3.8641E-02 1.0000E+00 3.8641E-02 3.8641E-02 3.8641E-02 56 1.503E+00 7.000E+00 9.000E+01 1.8377E-02 1.8377E-02 1.0000E+00 1.8377E-02 1.8377E-02 1.8377E-02 57 1.504E+00 8.000E+00 9.000E+01 8.3964E-03 8.3964E-03 1.0000E+00 8.3964E-03 8.3964E-03 8.3964E-03 58 1.504E+00 9.000E+00 9.000E+01 3.7006E-03 3.7006E-03 1.0000E+00 3.7006E-03 3.7006E-03 3.7006E-03 59 1.505E+00 1.000E+01 9.000E+01 1.5787E-03 1.5787E-03 1.0000E+00 1.5787E-03 1.5787E-03 1.5787E-03 60 1.506E+00 1.250E+01 9.000E+01 1.6563E-04 1.6563E-04 1.0000E+00 1.6563E-04 1.6563E-04 1.6563E-04 61 1.507E+00 1.500E+01 9.000E+01 1.4930E-05 1.4930E-05 1.0000E+00 1.4930E-05 1.4930E-05 1.4930E-05 62 1.508E+00 1.750E+01 9.000E+01 1.1858E-06 1.1858E-06 1.0000E+00 1.1858E-06 1.1858E-06 1.1858E-06 63 1.509E+00 2.000E+01 9.000E+01 8.4571E-08 8.4571E-08 1.0000E+00 8.4571E-08 8.4571E-08 8.4571E-08 64 1.512E+00 2.500E+01 9.000E+01 3.2991E-10 3.2991E-10 1.0000E+00 3.2991E-10 3.2991E-10 3.2991E-10 65 1.514E+00 3.000E+01 9.000E+01 9.7075E-13 9.7075E-13 1.0000E+00 9.7075E-13 9.7075E-13 9.7075E-13 66 1.516E+00 3.500E+01 9.000E+01 2.2991E-15 2.2991E-15 1.0000E+00 2.2991E-15 2.2991E-15 2.2991E-15 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 9.600E-01 8.454E-01 0.00E+00 8.45359E-01 3.485E-06 3.485E-06 3.593E-06 3 2.500E-01 9.600E-01 2.114E+00 0.00E+00 2.11401E+00 8.318E-06 8.318E-06 8.985E-06 4 5.000E-01 9.600E-01 4.229E+00 0.00E+00 4.22931E+00 1.536E-05 1.536E-05 1.797E-05 5 1.000E+00 9.600E-01 8.462E+00 0.00E+00 8.46206E+00 2.608E-05 2.608E-05 3.596E-05 6 1.500E+00 9.600E-01 1.270E+01 0.00E+00 1.26965E+01 3.305E-05 3.305E-05 5.396E-05 7 2.000E+00 9.600E-01 1.693E+01 0.00E+00 1.69319E+01 3.716E-05 3.716E-05 7.196E-05 8 3.000E+00 9.600E-01 2.540E+01 0.00E+00 2.54039E+01 3.952E-05 3.952E-05 1.080E-04 9 4.000E+00 9.600E-01 3.388E+01 0.00E+00 3.38765E+01 3.730E-05 3.730E-05 1.440E-04 10 5.000E+00 9.600E-01 4.235E+01 0.00E+00 4.23492E+01 3.300E-05 3.300E-05 1.800E-04 11 6.000E+00 9.600E-01 5.082E+01 0.00E+00 5.08219E+01 2.802E-05 2.802E-05 2.160E-04 12 7.000E+00 9.600E-01 5.929E+01 0.00E+00 5.92947E+01 2.313E-05 2.313E-05 2.520E-04 13 8.000E+00 9.600E-01 6.777E+01 0.00E+00 6.77675E+01 1.870E-05 1.870E-05 2.880E-04 14 9.000E+00 9.600E-01 7.624E+01 0.00E+00 7.62402E+01 1.488E-05 1.488E-05 3.240E-04 15 1.000E+01 9.600E-01 8.471E+01 0.00E+00 8.47130E+01 1.170E-05 1.170E-05 3.600E-04 16 1.250E+01 9.600E-01 1.059E+02 0.00E+00 1.05895E+02 6.158E-06 6.158E-06 4.500E-04 17 1.500E+01 9.600E-01 1.271E+02 0.00E+00 1.27077E+02 3.111E-06 3.111E-06 5.399E-04 18 1.750E+01 9.600E-01 1.483E+02 0.00E+00 1.48259E+02 1.528E-06 1.528E-06 6.299E-04 19 2.000E+01 9.600E-01 1.694E+02 0.00E+00 1.69441E+02 7.353E-07 7.353E-07 7.199E-04 20 2.500E+01 9.600E-01 2.118E+02 0.00E+00 2.11805E+02 1.629E-07 1.629E-07 8.998E-04 21 3.000E+01 9.600E-01 2.542E+02 0.00E+00 2.54168E+02 3.466E-08 3.466E-08 1.080E-03 22 3.500E+01 9.600E-01 2.965E+02 0.00E+00 2.96532E+02 7.167E-09 7.167E-09 1.259E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 4.560E+00 8.455E-01 0.00E+00 8.45519E-01 3.485E-06 3.485E-06 3.593E-06 25 2.500E-01 4.560E+00 2.115E+00 0.00E+00 2.11529E+00 8.316E-06 8.316E-06 8.990E-06 26 5.000E-01 4.560E+00 4.234E+00 0.00E+00 4.23400E+00 1.533E-05 1.533E-05 1.799E-05 27 1.000E+00 4.560E+00 8.477E+00 0.00E+00 8.47658E+00 2.579E-05 2.579E-05 3.602E-05 28 1.500E+00 4.560E+00 1.272E+01 0.00E+00 1.27239E+01 3.220E-05 3.220E-05 5.408E-05 29 2.000E+00 4.560E+00 1.698E+01 0.00E+00 1.69750E+01 3.541E-05 3.541E-05 7.214E-05 30 3.000E+00 4.560E+00 2.549E+01 0.00E+00 2.54867E+01 3.540E-05 3.540E-05 1.083E-04 31 4.000E+00 4.560E+00 3.401E+01 0.00E+00 3.40080E+01 3.078E-05 3.078E-05 1.445E-04 32 5.000E+00 4.560E+00 4.254E+01 0.00E+00 4.25364E+01 2.470E-05 2.470E-05 1.808E-04 33 6.000E+00 4.560E+00 5.107E+01 0.00E+00 5.10700E+01 1.882E-05 1.882E-05 2.170E-04 34 7.000E+00 4.560E+00 5.961E+01 0.00E+00 5.96073E+01 1.383E-05 1.383E-05 2.533E-04 35 8.000E+00 4.560E+00 6.815E+01 0.00E+00 6.81474E+01 9.894E-06 9.894E-06 2.896E-04 36 9.000E+00 4.560E+00 7.669E+01 0.00E+00 7.66895E+01 6.939E-06 6.939E-06 3.259E-04 37 1.000E+01 4.560E+00 8.523E+01 0.00E+00 8.52330E+01 4.792E-06 4.792E-06 3.622E-04 38 1.250E+01 4.560E+00 1.066E+02 0.00E+00 1.06596E+02 1.809E-06 1.809E-06 4.529E-04 39 1.500E+01 4.560E+00 1.280E+02 0.00E+00 1.27962E+02 6.512E-07 6.512E-07 5.437E-04 40 1.750E+01 4.560E+00 1.493E+02 0.00E+00 1.49329E+02 2.273E-07 2.273E-07 6.344E-04 41 2.000E+01 4.560E+00 1.707E+02 0.00E+00 1.70696E+02 7.759E-08 7.759E-08 7.252E-04 42 2.500E+01 4.560E+00 2.134E+02 0.00E+00 2.13432E+02 8.644E-09 8.644E-09 9.067E-04 43 3.000E+01 4.560E+00 2.562E+02 0.00E+00 2.56169E+02 9.238E-10 9.238E-10 1.088E-03 44 3.500E+01 4.560E+00 2.989E+02 0.00E+00 2.98905E+02 9.598E-11 9.598E-11 1.270E-03 45 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 46 1.000E-01 9.000E+01 8.456E-01 0.00E+00 8.45584E-01 3.486E-06 3.486E-06 3.594E-06 47 2.500E-01 9.000E+01 2.116E+00 0.00E+00 2.11615E+00 8.315E-06 8.315E-06 8.994E-06 48 5.000E-01 9.000E+01 4.239E+00 0.00E+00 4.23941E+00 1.530E-05 1.530E-05 1.802E-05 49 1.000E+00 9.000E+01 8.506E+00 0.00E+00 8.50571E+00 2.543E-05 2.543E-05 3.615E-05 50 1.500E+00 9.000E+01 1.280E+01 0.00E+00 1.27961E+01 3.096E-05 3.096E-05 5.438E-05 51 2.000E+00 9.000E+01 1.711E+01 0.00E+00 1.71082E+01 3.280E-05 3.280E-05 7.271E-05 52 3.000E+00 9.000E+01 2.579E+01 0.00E+00 2.57888E+01 2.933E-05 2.933E-05 1.096E-04 53 4.000E+00 9.000E+01 3.453E+01 0.00E+00 3.45333E+01 2.178E-05 2.178E-05 1.468E-04 54 5.000E+00 9.000E+01 4.333E+01 0.00E+00 4.33303E+01 1.430E-05 1.430E-05 1.841E-04 55 6.000E+00 9.000E+01 5.217E+01 0.00E+00 5.21711E+01 8.567E-06 8.567E-06 2.217E-04 56 7.000E+00 9.000E+01 6.105E+01 0.00E+00 6.10488E+01 4.767E-06 4.767E-06 2.594E-04 57 8.000E+00 9.000E+01 6.996E+01 0.00E+00 6.99580E+01 2.496E-06 2.496E-06 2.973E-04 58 9.000E+00 9.000E+01 7.889E+01 0.00E+00 7.88944E+01 1.241E-06 1.241E-06 3.352E-04 59 1.000E+01 9.000E+01 8.785E+01 0.00E+00 8.78547E+01 5.893E-07 5.893E-07 3.733E-04 60 1.250E+01 9.000E+01 1.103E+02 0.00E+00 1.10343E+02 7.766E-08 7.766E-08 4.688E-04 61 1.500E+01 9.000E+01 1.329E+02 0.00E+00 1.32934E+02 8.433E-09 8.433E-09 5.648E-04 62 1.750E+01 9.000E+01 1.556E+02 0.00E+00 1.55608E+02 7.839E-10 7.839E-10 6.611E-04 63 2.000E+01 9.000E+01 1.784E+02 0.00E+00 1.78353E+02 6.408E-11 6.408E-11 7.577E-04 64 2.500E+01 9.000E+01 2.240E+02 0.00E+00 2.24021E+02 3.140E-13 3.140E-13 9.516E-04 65 3.000E+01 9.000E+01 2.699E+02 0.00E+00 2.69883E+02 1.113E-15 1.113E-15 1.146E-03 66 3.500E+01 9.000E+01 3.159E+02 0.00E+00 3.15900E+02 3.085E-18 3.085E-18 1.342E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 9.600E-01 8.454E-01 3.485E-06 3.593E-06 6.8995E-05 6.9038E-05 6.6969E-05 3 2.500E-01 9.600E-01 2.114E+00 8.318E-06 8.985E-06 6.8995E-05 6.9102E-05 6.3974E-05 4 5.000E-01 9.600E-01 4.229E+00 1.536E-05 1.797E-05 6.8994E-05 6.9208E-05 5.9161E-05 5 1.000E+00 9.600E-01 8.462E+00 2.608E-05 3.596E-05 6.8993E-05 6.9422E-05 5.0336E-05 6 1.500E+00 9.600E-01 1.270E+01 3.305E-05 5.396E-05 6.8991E-05 6.9635E-05 4.2657E-05 7 2.000E+00 9.600E-01 1.693E+01 3.716E-05 7.196E-05 6.8990E-05 6.9849E-05 3.6073E-05 8 3.000E+00 9.600E-01 2.540E+01 3.952E-05 1.080E-04 6.8988E-05 7.0276E-05 2.5725E-05 9 4.000E+00 9.600E-01 3.388E+01 3.730E-05 1.440E-04 6.8985E-05 7.0703E-05 1.8320E-05 10 5.000E+00 9.600E-01 4.235E+01 3.300E-05 1.800E-04 6.8983E-05 7.1130E-05 1.3042E-05 11 6.000E+00 9.600E-01 5.082E+01 2.802E-05 2.160E-04 6.8980E-05 7.1556E-05 9.2827E-06 12 7.000E+00 9.600E-01 5.929E+01 2.313E-05 2.520E-04 6.8978E-05 7.1983E-05 6.6068E-06 13 8.000E+00 9.600E-01 6.777E+01 1.870E-05 2.880E-04 6.8975E-05 7.2410E-05 4.7021E-06 14 9.000E+00 9.600E-01 7.624E+01 1.488E-05 3.240E-04 6.8973E-05 7.2837E-05 3.3463E-06 15 1.000E+01 9.600E-01 8.471E+01 1.170E-05 3.600E-04 6.8970E-05 7.3264E-05 2.3814E-06 16 1.250E+01 9.600E-01 1.059E+02 6.158E-06 4.500E-04 6.8964E-05 7.4331E-05 1.0173E-06 17 1.500E+01 9.600E-01 1.271E+02 3.111E-06 5.399E-04 6.8958E-05 7.5398E-05 4.3446E-07 18 1.750E+01 9.600E-01 1.483E+02 1.528E-06 6.299E-04 6.8952E-05 7.6465E-05 1.8551E-07 19 2.000E+01 9.600E-01 1.694E+02 7.353E-07 7.199E-04 6.8946E-05 7.7532E-05 7.9197E-08 20 2.500E+01 9.600E-01 2.118E+02 1.629E-07 8.998E-04 6.8933E-05 7.9666E-05 1.4426E-08 21 3.000E+01 9.600E-01 2.542E+02 3.466E-08 1.080E-03 6.8921E-05 8.1799E-05 2.6257E-09 22 3.500E+01 9.600E-01 2.965E+02 7.167E-09 1.259E-03 6.8908E-05 8.3932E-05 4.7761E-10 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 4.560E+00 8.455E-01 3.485E-06 3.593E-06 6.8995E-05 6.9038E-05 6.6963E-05 25 2.500E-01 4.560E+00 2.115E+00 8.316E-06 8.990E-06 6.8995E-05 6.9102E-05 6.3923E-05 26 5.000E-01 4.560E+00 4.234E+00 1.533E-05 1.799E-05 6.8994E-05 6.9209E-05 5.8966E-05 27 1.000E+00 4.560E+00 8.477E+00 2.579E-05 3.602E-05 6.8993E-05 6.9422E-05 4.9700E-05 28 1.500E+00 4.560E+00 1.272E+01 3.220E-05 5.408E-05 6.8991E-05 6.9637E-05 4.1460E-05 29 2.000E+00 4.560E+00 1.698E+01 3.541E-05 7.214E-05 6.8990E-05 6.9851E-05 3.4289E-05 30 3.000E+00 4.560E+00 2.549E+01 3.540E-05 1.083E-04 6.8988E-05 7.0280E-05 2.2967E-05 31 4.000E+00 4.560E+00 3.401E+01 3.078E-05 1.445E-04 6.8985E-05 7.0709E-05 1.5058E-05 32 5.000E+00 4.560E+00 4.254E+01 2.470E-05 1.808E-04 6.8983E-05 7.1139E-05 9.7214E-06 33 6.000E+00 4.560E+00 5.107E+01 1.882E-05 2.170E-04 6.8980E-05 7.1569E-05 6.2064E-06 34 7.000E+00 4.560E+00 5.961E+01 1.383E-05 2.533E-04 6.8978E-05 7.1999E-05 3.9305E-06 35 8.000E+00 4.560E+00 6.815E+01 9.894E-06 2.896E-04 6.8975E-05 7.2429E-05 2.4747E-06 36 9.000E+00 4.560E+00 7.669E+01 6.939E-06 3.259E-04 6.8973E-05 7.2860E-05 1.5515E-06 37 1.000E+01 4.560E+00 8.523E+01 4.792E-06 3.622E-04 6.8970E-05 7.3290E-05 9.6972E-07 38 1.250E+01 4.560E+00 1.066E+02 1.809E-06 4.529E-04 6.8964E-05 7.4367E-05 2.9698E-07 39 1.500E+01 4.560E+00 1.280E+02 6.512E-07 5.437E-04 6.8958E-05 7.5443E-05 9.0358E-08 40 1.750E+01 4.560E+00 1.493E+02 2.273E-07 6.344E-04 6.8951E-05 7.6519E-05 2.7409E-08 41 2.000E+01 4.560E+00 1.707E+02 7.759E-08 7.252E-04 6.8945E-05 7.7596E-05 8.3023E-09 42 2.500E+01 4.560E+00 2.134E+02 8.644E-09 9.067E-04 6.8933E-05 7.9748E-05 7.6027E-10 43 3.000E+01 4.560E+00 2.562E+02 9.238E-10 1.088E-03 6.8920E-05 8.1900E-05 6.9533E-11 44 3.500E+01 4.560E+00 2.989E+02 9.598E-11 1.270E-03 6.8908E-05 8.4051E-05 6.3544E-12 45 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 46 1.000E-01 9.000E+01 8.456E-01 3.486E-06 3.594E-06 6.8995E-05 6.9038E-05 6.6960E-05 47 2.500E-01 9.000E+01 2.116E+00 8.315E-06 8.994E-06 6.8995E-05 6.9102E-05 6.3891E-05 48 5.000E-01 9.000E+01 4.239E+00 1.530E-05 1.802E-05 6.8994E-05 6.9209E-05 5.8778E-05 49 1.000E+00 9.000E+01 8.506E+00 2.543E-05 3.615E-05 6.8993E-05 6.9424E-05 4.8833E-05 50 1.500E+00 9.000E+01 1.280E+01 3.096E-05 5.438E-05 6.8991E-05 6.9640E-05 3.9648E-05 51 2.000E+00 9.000E+01 1.711E+01 3.280E-05 7.271E-05 6.8990E-05 6.9857E-05 3.1517E-05 52 3.000E+00 9.000E+01 2.579E+01 2.933E-05 1.096E-04 6.8988E-05 7.0295E-05 1.8811E-05 53 4.000E+00 9.000E+01 3.453E+01 2.178E-05 1.468E-04 6.8985E-05 7.0736E-05 1.0499E-05 54 5.000E+00 9.000E+01 4.333E+01 1.430E-05 1.841E-04 6.8983E-05 7.1179E-05 5.5293E-06 55 6.000E+00 9.000E+01 5.217E+01 8.567E-06 2.217E-04 6.8980E-05 7.1624E-05 2.7676E-06 56 7.000E+00 9.000E+01 6.105E+01 4.767E-06 2.594E-04 6.8977E-05 7.2072E-05 1.3244E-06 57 8.000E+00 9.000E+01 6.996E+01 2.496E-06 2.973E-04 6.8975E-05 7.2521E-05 6.0891E-07 58 9.000E+00 9.000E+01 7.889E+01 1.241E-06 3.352E-04 6.8972E-05 7.2971E-05 2.7004E-07 59 1.000E+01 9.000E+01 8.785E+01 5.893E-07 3.733E-04 6.8969E-05 7.3422E-05 1.1591E-07 60 1.250E+01 9.000E+01 1.103E+02 7.766E-08 4.688E-04 6.8963E-05 7.4555E-05 1.2349E-08 61 1.500E+01 9.000E+01 1.329E+02 8.433E-09 5.648E-04 6.8956E-05 7.5693E-05 1.1301E-09 62 1.750E+01 9.000E+01 1.556E+02 7.839E-10 6.611E-04 6.8950E-05 7.6836E-05 9.1110E-11 63 2.000E+01 9.000E+01 1.784E+02 6.408E-11 7.577E-04 6.8943E-05 7.7981E-05 6.5950E-12 64 2.500E+01 9.000E+01 2.240E+02 3.140E-13 9.516E-04 6.8930E-05 8.0281E-05 2.6485E-14 65 3.000E+01 9.000E+01 2.699E+02 1.113E-15 1.146E-03 6.8916E-05 8.2590E-05 8.0174E-17 66 3.500E+01 9.000E+01 3.159E+02 3.085E-18 1.342E-03 6.8903E-05 8.4907E-05 1.9520E-19 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.3001 (1/Gy), alpha/beta = 5.4732 (Gy), lamda1 = 2.179E+01 (1/h), lamda2 = 1.171E+00 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 1.042E-01 3.610E+01 1.000E-01 9.600E-01 5.331E-01 9.606E-01 7.511E-01 9.7003E-01 9.700344E-01 3 2.604E-01 3.626E+01 2.500E-01 9.600E-01 2.906E-01 9.057E-01 6.034E-01 9.2579E-01 9.257993E-01 4 5.208E-01 3.652E+01 5.000E-01 9.600E-01 1.607E-01 8.243E-01 4.966E-01 8.5476E-01 8.548173E-01 5 1.042E+00 3.704E+01 1.000E+00 9.600E-01 8.424E-02 6.924E-01 3.895E-01 7.2480E-01 7.250784E-01 6 1.562E+00 3.756E+01 1.500E+00 9.600E-01 5.702E-02 5.915E-01 3.235E-01 6.1197E-01 6.125739E-01 7 2.083E+00 3.808E+01 2.000E+00 9.600E-01 4.309E-02 5.131E-01 2.761E-01 5.1550E-01 5.164425E-01 8 3.125E+00 3.912E+01 3.000E+00 9.600E-01 2.894E-02 4.010E-01 2.120E-01 3.6461E-01 3.660553E-01 9 4.167E+00 4.017E+01 4.000E+00 9.600E-01 2.179E-02 3.265E-01 1.710E-01 2.5747E-01 2.591152E-01 10 5.208E+00 4.121E+01 5.000E+00 9.600E-01 1.747E-02 2.743E-01 1.428E-01 1.8172E-01 1.833499E-01 11 6.250E+00 4.225E+01 6.000E+00 9.600E-01 1.458E-02 2.360E-01 1.224E-01 1.2824E-01 1.297254E-01 12 7.292E+00 4.329E+01 7.000E+00 9.600E-01 1.251E-02 2.068E-01 1.070E-01 9.0494E-02 9.178201E-02 13 8.333E+00 4.433E+01 8.000E+00 9.600E-01 1.095E-02 1.840E-01 9.500E-02 6.3858E-02 6.493620E-02 14 9.375E+00 4.538E+01 9.000E+00 9.600E-01 9.744E-03 1.656E-01 8.540E-02 4.5061E-02 4.594257E-02 15 1.042E+01 4.642E+01 1.000E+01 9.600E-01 8.774E-03 1.505E-01 7.754E-02 3.1798E-02 3.250450E-02 16 1.302E+01 4.902E+01 1.250E+01 9.600E-01 7.025E-03 1.226E-01 6.302E-02 1.3301E-02 1.368559E-02 17 1.562E+01 5.162E+01 1.500E+01 9.600E-01 5.858E-03 1.033E-01 5.306E-02 5.5636E-03 5.762140E-03 18 1.823E+01 5.423E+01 1.750E+01 9.600E-01 5.023E-03 8.931E-02 4.582E-02 2.3272E-03 2.426074E-03 19 2.083E+01 5.683E+01 2.000E+01 9.600E-01 4.397E-03 7.862E-02 4.031E-02 9.7345E-04 1.021467E-03 20 2.604E+01 6.204E+01 2.500E+01 9.600E-01 3.519E-03 6.344E-02 3.249E-02 1.7032E-04 1.810775E-04 21 3.125E+01 6.725E+01 3.000E+01 9.600E-01 2.933E-03 5.316E-02 2.721E-02 2.9801E-05 3.209999E-05 22 3.646E+01 7.246E+01 3.500E+01 9.600E-01 2.515E-03 4.575E-02 2.341E-02 5.2142E-06 5.690432E-06 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 2.193E-02 3.602E+01 1.000E-01 4.560E+00 8.581E-01 9.915E-01 9.248E-01 9.6994E-01 9.699420E-01 25 5.482E-02 3.605E+01 2.500E-01 4.560E+00 6.971E-01 9.789E-01 8.378E-01 9.2504E-01 9.250559E-01 26 1.096E-01 3.611E+01 5.000E-01 4.560E+00 5.189E-01 9.585E-01 7.375E-01 8.5192E-01 8.519991E-01 27 2.193E-01 3.622E+01 1.000E+00 4.560E+00 3.317E-01 9.196E-01 6.215E-01 7.1544E-01 7.159101E-01 28 3.289E-01 3.633E+01 1.500E+00 4.560E+00 2.402E-01 8.831E-01 5.542E-01 5.9420E-01 5.953810E-01 29 4.386E-01 3.644E+01 2.000E+00 4.560E+00 1.874E-01 8.487E-01 5.075E-01 4.8880E-01 4.908834E-01 30 6.579E-01 3.666E+01 3.000E+00 4.560E+00 1.298E-01 7.859E-01 4.419E-01 3.2282E-01 3.267892E-01 31 8.772E-01 3.688E+01 4.000E+00 4.560E+00 9.917E-02 7.302E-01 3.946E-01 2.0769E-01 2.129572E-01 32 1.096E+00 3.710E+01 5.000E+00 4.560E+00 8.021E-02 6.805E-01 3.572E-01 1.3094E-01 1.366542E-01 33 1.316E+00 3.732E+01 6.000E+00 4.560E+00 6.733E-02 6.361E-01 3.264E-01 8.1267E-02 8.671980E-02 34 1.535E+00 3.754E+01 7.000E+00 4.560E+00 5.801E-02 5.962E-01 3.004E-01 4.9830E-02 5.459092E-02 35 1.754E+00 3.775E+01 8.000E+00 4.560E+00 5.095E-02 5.604E-01 2.780E-01 3.0269E-02 3.416644E-02 36 1.974E+00 3.797E+01 9.000E+00 4.560E+00 4.543E-02 5.281E-01 2.585E-01 1.8253E-02 2.129399E-02 37 2.193E+00 3.819E+01 1.000E+01 4.560E+00 4.098E-02 4.988E-01 2.415E-01 1.0946E-02 1.323117E-02 38 2.741E+00 3.874E+01 1.250E+01 4.560E+00 3.293E-02 4.368E-01 2.068E-01 2.9970E-03 3.993479E-03 39 3.289E+00 3.929E+01 1.500E+01 4.560E+00 2.752E-02 3.873E-01 1.804E-01 8.0863E-04 1.197702E-03 40 3.838E+00 3.984E+01 1.750E+01 4.560E+00 2.363E-02 3.471E-01 1.597E-01 2.1649E-04 3.581999E-04 41 4.386E+00 4.039E+01 2.000E+01 4.560E+00 2.071E-02 3.140E-01 1.432E-01 5.7726E-05 1.069944E-04 42 5.482E+00 4.148E+01 2.500E+01 4.560E+00 1.660E-02 2.631E-01 1.184E-01 4.0821E-06 9.533378E-06 43 6.579E+00 4.258E+01 3.000E+01 4.560E+00 1.386E-02 2.259E-01 1.008E-01 2.8790E-07 8.490075E-07 44 7.675E+00 4.368E+01 3.500E+01 4.560E+00 1.189E-02 1.978E-01 8.774E-02 2.0291E-08 7.560193E-08 45 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 46 1.111E-03 3.600E+01 1.000E-01 9.000E+01 9.920E-01 9.996E-01 9.940E-01 9.6990E-01 9.699052E-01 47 2.778E-03 3.600E+01 2.500E-01 9.000E+01 9.801E-01 9.989E-01 9.851E-01 9.2457E-01 9.245891E-01 48 5.556E-03 3.601E+01 5.000E-01 9.000E+01 9.608E-01 9.978E-01 9.706E-01 8.4917E-01 8.492806E-01 49 1.111E-02 3.601E+01 1.000E+00 9.000E+01 9.240E-01 9.957E-01 9.430E-01 7.0272E-01 7.034024E-01 50 1.667E-02 3.602E+01 1.500E+00 9.000E+01 8.892E-01 9.935E-01 9.169E-01 5.6751E-01 5.693277E-01 51 2.222E-02 3.602E+01 2.000E+00 9.000E+01 8.564E-01 9.914E-01 8.922E-01 4.4786E-01 4.511599E-01 52 3.333E-02 3.603E+01 3.000E+00 9.000E+01 7.962E-01 9.871E-01 8.468E-01 2.6141E-01 2.675976E-01 53 4.444E-02 3.604E+01 4.000E+00 9.000E+01 7.424E-01 9.829E-01 8.060E-01 1.4084E-01 1.484275E-01 54 5.556E-02 3.606E+01 5.000E+00 9.000E+01 6.941E-01 9.787E-01 7.693E-01 7.0481E-02 7.768199E-02 55 6.667E-02 3.607E+01 6.000E+00 9.000E+01 6.508E-01 9.745E-01 7.359E-01 3.2928E-02 3.864105E-02 56 7.778E-02 3.608E+01 7.000E+00 9.000E+01 6.117E-01 9.703E-01 7.056E-01 1.4421E-02 1.837672E-02 57 8.889E-02 3.609E+01 8.000E+00 9.000E+01 5.764E-01 9.662E-01 6.779E-01 5.9404E-03 8.396368E-03 58 1.000E-01 3.610E+01 9.000E+00 9.000E+01 5.443E-01 9.621E-01 6.525E-01 2.3081E-03 3.700636E-03 59 1.111E-01 3.611E+01 1.000E+01 9.000E+01 5.152E-01 9.580E-01 6.292E-01 8.4779E-04 1.578691E-03 60 1.389E-01 3.614E+01 1.250E+01 9.000E+01 4.531E-01 9.479E-01 5.782E-01 5.4887E-05 1.656336E-04 61 1.667E-01 3.617E+01 1.500E+01 9.000E+01 4.031E-01 9.380E-01 5.358E-01 2.5912E-06 1.493031E-05 62 1.944E-01 3.619E+01 1.750E+01 9.000E+01 3.623E-01 9.282E-01 4.998E-01 9.0749E-08 1.185779E-06 63 2.222E-01 3.622E+01 2.000E+01 9.000E+01 3.284E-01 9.186E-01 4.688E-01 2.3895E-09 8.457122E-08 64 2.778E-01 3.628E+01 2.500E+01 9.000E+01 2.760E-01 8.998E-01 4.181E-01 7.3538E-13 3.299089E-10 65 3.333E-01 3.633E+01 3.000E+01 9.000E+01 2.375E-01 8.817E-01 3.781E-01 8.1558E-17 9.707514E-13 66 3.889E-01 3.639E+01 3.500E+01 9.000E+01 2.082E-01 8.640E-01 3.454E-01 3.4838E-21 2.299051E-15 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 1.504E+00 1.000E-01 9.7003E-01 9.7003E-01 9.7003E-01 3.7907E-01 3.7907E-01 3.7907E-01 3.7907E-01 3 1.511E+00 2.500E-01 9.2580E-01 9.2580E-01 9.2580E-01 3.9621E-01 3.9621E-01 3.9621E-01 3.9621E-01 4 1.522E+00 5.000E-01 8.5482E-01 8.5482E-01 8.5482E-01 4.2536E-01 4.2536E-01 4.2536E-01 4.2536E-01 5 1.543E+00 1.000E+00 7.2508E-01 7.2508E-01 7.2508E-01 4.8429E-01 4.8429E-01 4.8429E-01 4.8429E-01 6 1.565E+00 1.500E+00 6.1257E-01 6.1257E-01 6.1257E-01 5.4195E-01 5.4195E-01 5.4195E-01 5.4195E-01 7 1.587E+00 2.000E+00 5.1644E-01 5.1644E-01 5.1644E-01 5.9664E-01 5.9664E-01 5.9664E-01 5.9664E-01 8 1.630E+00 3.000E+00 3.6606E-01 3.6606E-01 3.6606E-01 6.9346E-01 6.9346E-01 6.9346E-01 6.9346E-01 9 1.674E+00 4.000E+00 2.5912E-01 2.5912E-01 2.5912E-01 7.7173E-01 7.7173E-01 7.7173E-01 7.7173E-01 10 1.717E+00 5.000E+00 1.8335E-01 1.8335E-01 1.8335E-01 8.3248E-01 8.3248E-01 8.3248E-01 8.3248E-01 11 1.760E+00 6.000E+00 1.2973E-01 1.2973E-01 1.2973E-01 8.7834E-01 8.7834E-01 8.7834E-01 8.7834E-01 12 1.804E+00 7.000E+00 9.1782E-02 9.1782E-02 9.1782E-02 9.1230E-01 9.1230E-01 9.1230E-01 9.1230E-01 13 1.847E+00 8.000E+00 6.4936E-02 6.4936E-02 6.4936E-02 9.3713E-01 9.3713E-01 9.3713E-01 9.3713E-01 14 1.891E+00 9.000E+00 4.5943E-02 4.5943E-02 4.5943E-02 9.5510E-01 9.5510E-01 9.5510E-01 9.5510E-01 15 1.934E+00 1.000E+01 3.2504E-02 3.2504E-02 3.2504E-02 9.6802E-01 9.6802E-01 9.6802E-01 9.6802E-01 16 2.043E+00 1.250E+01 1.3686E-02 1.3686E-02 1.3686E-02 9.8641E-01 9.8641E-01 9.8641E-01 9.8641E-01 17 2.151E+00 1.500E+01 5.7621E-03 5.7621E-03 5.7621E-03 9.9425E-01 9.9425E-01 9.9425E-01 9.9425E-01 18 2.260E+00 1.750E+01 2.4261E-03 2.4261E-03 2.4261E-03 9.9758E-01 9.9758E-01 9.9758E-01 9.9758E-01 19 2.368E+00 2.000E+01 1.0215E-03 1.0215E-03 1.0215E-03 9.9898E-01 9.9898E-01 9.9898E-01 9.9898E-01 20 2.585E+00 2.500E+01 1.8108E-04 1.8108E-04 1.8108E-04 9.9982E-01 9.9982E-01 9.9982E-01 9.9982E-01 21 2.802E+00 3.000E+01 3.2100E-05 3.2100E-05 3.2100E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 22 3.019E+00 3.500E+01 5.6904E-06 5.6904E-06 5.6904E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 1.501E+00 1.000E-01 9.6994E-01 9.6994E-01 9.6994E-01 3.7911E-01 3.7911E-01 3.7911E-01 3.7911E-01 25 1.502E+00 2.500E-01 9.2506E-01 9.2506E-01 9.2506E-01 3.9651E-01 3.9651E-01 3.9651E-01 3.9651E-01 26 1.505E+00 5.000E-01 8.5200E-01 8.5200E-01 8.5200E-01 4.2656E-01 4.2656E-01 4.2656E-01 4.2656E-01 27 1.509E+00 1.000E+00 7.1591E-01 7.1591E-01 7.1591E-01 4.8875E-01 4.8875E-01 4.8875E-01 4.8875E-01 28 1.514E+00 1.500E+00 5.9538E-01 5.9538E-01 5.9538E-01 5.5135E-01 5.5135E-01 5.5135E-01 5.5135E-01 29 1.518E+00 2.000E+00 4.9088E-01 4.9088E-01 4.9088E-01 6.1209E-01 6.1209E-01 6.1209E-01 6.1209E-01 30 1.527E+00 3.000E+00 3.2679E-01 3.2679E-01 3.2679E-01 7.2124E-01 7.2124E-01 7.2124E-01 7.2124E-01 31 1.537E+00 4.000E+00 2.1296E-01 2.1296E-01 2.1296E-01 8.0819E-01 8.0819E-01 8.0819E-01 8.0819E-01 32 1.546E+00 5.000E+00 1.3665E-01 1.3665E-01 1.3665E-01 8.7227E-01 8.7227E-01 8.7227E-01 8.7227E-01 33 1.555E+00 6.000E+00 8.6720E-02 8.6720E-02 8.6720E-02 9.1693E-01 9.1693E-01 9.1693E-01 9.1693E-01 34 1.564E+00 7.000E+00 5.4591E-02 5.4591E-02 5.4591E-02 9.4687E-01 9.4687E-01 9.4687E-01 9.4687E-01 35 1.573E+00 8.000E+00 3.4166E-02 3.4166E-02 3.4166E-02 9.6641E-01 9.6641E-01 9.6641E-01 9.6641E-01 36 1.582E+00 9.000E+00 2.1294E-02 2.1294E-02 2.1294E-02 9.7893E-01 9.7893E-01 9.7893E-01 9.7893E-01 37 1.591E+00 1.000E+01 1.3231E-02 1.3231E-02 1.3231E-02 9.8686E-01 9.8686E-01 9.8686E-01 9.8686E-01 38 1.614E+00 1.250E+01 3.9935E-03 3.9935E-03 3.9935E-03 9.9601E-01 9.9601E-01 9.9601E-01 9.9601E-01 39 1.637E+00 1.500E+01 1.1977E-03 1.1977E-03 1.1977E-03 9.9880E-01 9.9880E-01 9.9880E-01 9.9880E-01 40 1.660E+00 1.750E+01 3.5820E-04 3.5820E-04 3.5820E-04 9.9964E-01 9.9964E-01 9.9964E-01 9.9964E-01 41 1.683E+00 2.000E+01 1.0699E-04 1.0699E-04 1.0699E-04 9.9989E-01 9.9989E-01 9.9989E-01 9.9989E-01 42 1.728E+00 2.500E+01 9.5334E-06 9.5334E-06 9.5334E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 43 1.774E+00 3.000E+01 8.4901E-07 8.4901E-07 8.4901E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 1.820E+00 3.500E+01 7.5602E-08 7.5602E-08 7.5602E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 45 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 46 1.500E+00 1.000E-01 9.6991E-01 9.6991E-01 9.6991E-01 3.7912E-01 3.7912E-01 3.7912E-01 3.7912E-01 47 1.500E+00 2.500E-01 9.2459E-01 9.2459E-01 9.2459E-01 3.9669E-01 3.9669E-01 3.9669E-01 3.9669E-01 48 1.500E+00 5.000E-01 8.4928E-01 8.4928E-01 8.4928E-01 4.2772E-01 4.2772E-01 4.2772E-01 4.2772E-01 49 1.500E+00 1.000E+00 7.0340E-01 7.0340E-01 7.0340E-01 4.9490E-01 4.9490E-01 4.9490E-01 4.9490E-01 50 1.501E+00 1.500E+00 5.6933E-01 5.6933E-01 5.6933E-01 5.6591E-01 5.6591E-01 5.6591E-01 5.6591E-01 51 1.501E+00 2.000E+00 4.5116E-01 4.5116E-01 4.5116E-01 6.3689E-01 6.3689E-01 6.3689E-01 6.3689E-01 52 1.501E+00 3.000E+00 2.6760E-01 2.6760E-01 2.6760E-01 7.6522E-01 7.6522E-01 7.6522E-01 7.6522E-01 53 1.502E+00 4.000E+00 1.4843E-01 1.4843E-01 1.4843E-01 8.6206E-01 8.6206E-01 8.6206E-01 8.6206E-01 54 1.502E+00 5.000E+00 7.7682E-02 7.7682E-02 7.7682E-02 9.2526E-01 9.2526E-01 9.2526E-01 9.2526E-01 55 1.503E+00 6.000E+00 3.8641E-02 3.8641E-02 3.8641E-02 9.6210E-01 9.6210E-01 9.6210E-01 9.6210E-01 56 1.503E+00 7.000E+00 1.8377E-02 1.8377E-02 1.8377E-02 9.8179E-01 9.8179E-01 9.8179E-01 9.8179E-01 57 1.504E+00 8.000E+00 8.3964E-03 8.3964E-03 8.3964E-03 9.9164E-01 9.9164E-01 9.9164E-01 9.9164E-01 58 1.504E+00 9.000E+00 3.7006E-03 3.7006E-03 3.7006E-03 9.9631E-01 9.9631E-01 9.9631E-01 9.9631E-01 59 1.505E+00 1.000E+01 1.5787E-03 1.5787E-03 1.5787E-03 9.9842E-01 9.9842E-01 9.9842E-01 9.9842E-01 60 1.506E+00 1.250E+01 1.6563E-04 1.6563E-04 1.6563E-04 9.9983E-01 9.9983E-01 9.9983E-01 9.9983E-01 61 1.507E+00 1.500E+01 1.4930E-05 1.4930E-05 1.4930E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 62 1.508E+00 1.750E+01 1.1858E-06 1.1858E-06 1.1858E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 63 1.509E+00 2.000E+01 8.4571E-08 8.4571E-08 8.4571E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 64 1.512E+00 2.500E+01 3.2991E-10 3.2991E-10 3.2991E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 65 1.514E+00 3.000E+01 9.7075E-13 9.7075E-13 9.7075E-13 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 66 1.516E+00 3.500E+01 2.2991E-15 2.2991E-15 2.2991E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 1.042E-01 4.340E-03 0.0000E+00 1.0000E-01 0.0000E+00 9.6000E-01 3 2.604E-01 1.085E-02 0.0000E+00 2.5000E-01 0.0000E+00 9.6000E-01 4 5.208E-01 2.170E-02 0.0000E+00 5.0000E-01 0.0000E+00 9.6000E-01 5 1.042E+00 4.340E-02 0.0000E+00 1.0000E+00 0.0000E+00 9.6000E-01 6 1.562E+00 6.510E-02 0.0000E+00 1.5000E+00 0.0000E+00 9.6000E-01 7 2.083E+00 8.681E-02 0.0000E+00 2.0000E+00 0.0000E+00 9.6000E-01 8 3.125E+00 1.302E-01 0.0000E+00 3.0000E+00 0.0000E+00 9.6000E-01 9 4.167E+00 1.736E-01 0.0000E+00 4.0000E+00 0.0000E+00 9.6000E-01 10 5.208E+00 2.170E-01 0.0000E+00 5.0000E+00 0.0000E+00 9.6000E-01 11 6.250E+00 2.604E-01 0.0000E+00 6.0000E+00 0.0000E+00 9.6000E-01 12 7.292E+00 3.038E-01 0.0000E+00 7.0000E+00 0.0000E+00 9.6000E-01 13 8.333E+00 3.472E-01 0.0000E+00 8.0000E+00 0.0000E+00 9.6000E-01 14 9.375E+00 3.906E-01 0.0000E+00 9.0000E+00 0.0000E+00 9.6000E-01 15 1.042E+01 4.340E-01 0.0000E+00 1.0000E+01 0.0000E+00 9.6000E-01 16 1.302E+01 5.425E-01 0.0000E+00 1.2500E+01 0.0000E+00 9.6000E-01 17 1.562E+01 6.510E-01 0.0000E+00 1.5000E+01 0.0000E+00 9.6000E-01 18 1.823E+01 7.595E-01 0.0000E+00 1.7500E+01 0.0000E+00 9.6000E-01 19 2.083E+01 8.681E-01 0.0000E+00 2.0000E+01 0.0000E+00 9.6000E-01 20 2.604E+01 1.085E+00 0.0000E+00 2.5000E+01 0.0000E+00 9.6000E-01 21 3.125E+01 1.302E+00 0.0000E+00 3.0000E+01 0.0000E+00 9.6000E-01 22 3.646E+01 1.519E+00 0.0000E+00 3.5000E+01 0.0000E+00 9.6000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 2.193E-02 9.137E-04 0.0000E+00 1.0000E-01 0.0000E+00 4.5600E+00 25 5.482E-02 2.284E-03 0.0000E+00 2.5000E-01 0.0000E+00 4.5600E+00 26 1.096E-01 4.569E-03 0.0000E+00 5.0000E-01 0.0000E+00 4.5600E+00 27 2.193E-01 9.137E-03 0.0000E+00 1.0000E+00 0.0000E+00 4.5600E+00 28 3.289E-01 1.371E-02 0.0000E+00 1.5000E+00 0.0000E+00 4.5600E+00 29 4.386E-01 1.827E-02 0.0000E+00 2.0000E+00 0.0000E+00 4.5600E+00 30 6.579E-01 2.741E-02 0.0000E+00 3.0000E+00 0.0000E+00 4.5600E+00 31 8.772E-01 3.655E-02 0.0000E+00 4.0000E+00 0.0000E+00 4.5600E+00 32 1.096E+00 4.569E-02 0.0000E+00 5.0000E+00 0.0000E+00 4.5600E+00 33 1.316E+00 5.482E-02 0.0000E+00 6.0000E+00 0.0000E+00 4.5600E+00 34 1.535E+00 6.396E-02 0.0000E+00 7.0000E+00 0.0000E+00 4.5600E+00 35 1.754E+00 7.310E-02 0.0000E+00 8.0000E+00 0.0000E+00 4.5600E+00 36 1.974E+00 8.224E-02 0.0000E+00 9.0000E+00 0.0000E+00 4.5600E+00 37 2.193E+00 9.137E-02 0.0000E+00 1.0000E+01 0.0000E+00 4.5600E+00 38 2.741E+00 1.142E-01 0.0000E+00 1.2500E+01 0.0000E+00 4.5600E+00 39 3.289E+00 1.371E-01 0.0000E+00 1.5000E+01 0.0000E+00 4.5600E+00 40 3.838E+00 1.599E-01 0.0000E+00 1.7500E+01 0.0000E+00 4.5600E+00 41 4.386E+00 1.827E-01 0.0000E+00 2.0000E+01 0.0000E+00 4.5600E+00 42 5.482E+00 2.284E-01 0.0000E+00 2.5000E+01 0.0000E+00 4.5600E+00 43 6.579E+00 2.741E-01 0.0000E+00 3.0000E+01 0.0000E+00 4.5600E+00 44 7.675E+00 3.198E-01 0.0000E+00 3.5000E+01 0.0000E+00 4.5600E+00 45 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 46 1.111E-03 4.630E-05 0.0000E+00 1.0000E-01 0.0000E+00 9.0000E+01 47 2.778E-03 1.157E-04 0.0000E+00 2.5000E-01 0.0000E+00 9.0000E+01 48 5.556E-03 2.315E-04 0.0000E+00 5.0000E-01 0.0000E+00 9.0000E+01 49 1.111E-02 4.630E-04 0.0000E+00 1.0000E+00 0.0000E+00 9.0000E+01 50 1.667E-02 6.944E-04 0.0000E+00 1.5000E+00 0.0000E+00 9.0000E+01 51 2.222E-02 9.259E-04 0.0000E+00 2.0000E+00 0.0000E+00 9.0000E+01 52 3.333E-02 1.389E-03 0.0000E+00 3.0000E+00 0.0000E+00 9.0000E+01 53 4.444E-02 1.852E-03 0.0000E+00 4.0000E+00 0.0000E+00 9.0000E+01 54 5.556E-02 2.315E-03 0.0000E+00 5.0000E+00 0.0000E+00 9.0000E+01 55 6.667E-02 2.778E-03 0.0000E+00 6.0000E+00 0.0000E+00 9.0000E+01 56 7.778E-02 3.241E-03 0.0000E+00 7.0000E+00 0.0000E+00 9.0000E+01 57 8.889E-02 3.704E-03 0.0000E+00 8.0000E+00 0.0000E+00 9.0000E+01 58 1.000E-01 4.167E-03 0.0000E+00 9.0000E+00 0.0000E+00 9.0000E+01 59 1.111E-01 4.630E-03 0.0000E+00 1.0000E+01 0.0000E+00 9.0000E+01 60 1.389E-01 5.787E-03 0.0000E+00 1.2500E+01 0.0000E+00 9.0000E+01 61 1.667E-01 6.944E-03 0.0000E+00 1.5000E+01 0.0000E+00 9.0000E+01 62 1.944E-01 8.102E-03 0.0000E+00 1.7500E+01 0.0000E+00 9.0000E+01 63 2.222E-01 9.259E-03 0.0000E+00 2.0000E+01 0.0000E+00 9.0000E+01 64 2.778E-01 1.157E-02 0.0000E+00 2.5000E+01 0.0000E+00 9.0000E+01 65 3.333E-01 1.389E-02 0.0000E+00 3.0000E+01 0.0000E+00 9.0000E+01 66 3.889E-01 1.620E-02 0.0000E+00 3.5000E+01 0.0000E+00 9.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 9.63333E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 03:02:15 PM