/*
REFERENCE:
Steel GG, Deacon JM, Duchesne GM, Horwich A, Kelland LR, and Peacock JH.
The dose-rate effect in
human tumour cells. Radiotherapy and Oncology. 9: 299-310 (1987)
PREPARED BY: JULIEN PARTOUCHE (julien@tamu.edu)
DATE: 22-JUL-2003
REVISED: RD STEWART 02-AUG-2003
Four-parameter fit instead of three-parameter fit (significantly better fit
to SF data)
COMMENTS: TLK with biphasic repair kinetics appears to give better fit than
LPL or RMR model.
*/
MODEL: DRM=TLK CKM=QECK
CELL: DNA=5.667D+09 NC=46
IRAD: CL=DSB
CLRP: RHT=HT4R BMR=8.2597109E-03 PHI=PML A0=PMR
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data
! TLK model inputs (simple and complex double strand breaks)
DSB = 20 5 / !Radiation damage to DNA
HT4R = 3.1814088E-02 5.9194403E-01 / !Half-times for DSB repair
PML = 3.4299332E-02 / !Probability a misrejoined DSB is lethal
PMR = 0.75 0.25 / !Probability DSB is rejoined correctly
! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10
! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09
!IRRADIATION CONDITIONS (single fraction)
RADX: ADR=RX1 AD=RX2
RX1 = 0.96 4.56 90 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 / |
