VC 2.00G 05-JUL-2003 23-JUL-2003 02:31:23 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: c:\vc\samples\bin\vc.exe c:\vc2\archive\hx118\lpl\hx118.inp FNI: C:\VC2\archive\hx118\lpl\hx118.inp FNO: C:\VC2\archive\hx118\lpl\hx118.out RADX: C:\VC2\archive\hx118\lpl\hx118.radx (66 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- LPLM TABLE: Summary of LPL parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 RADIATION DAMAGE: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 7.17785E-12 4.41151E-03 25.000000 FL = 9.02763E-14 5.54838E-05 0.314427 DAMAGE REPAIR/MISREPAIR: A0= 9.500000E-01 (=95.000%) (1-A0)= 5.000000E-02 (=5.000%) RHT= 0.282914 h (=16.97 minute) LAM= 2.4500273E+00 (1/h) BMR= 1.2243103E-03 (1/h) LAM/BMR= 2.0011490E+03 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 0.314427 (1/Gy) beta = 0.039040 (1/Gy^2) alpha/beta = 8.053951 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 1.042E-01 2.410E+01 1.000E-01 9.600E-01 3.589E-04 3.144E-02 3.1802E-02 9.686988E-01 3 2.604E-01 2.426E+01 2.500E-01 9.600E-01 1.991E-03 7.861E-02 8.0597E-02 9.225651E-01 4 5.208E-01 2.452E+01 5.000E-01 9.600E-01 6.633E-03 1.572E-01 1.6385E-01 8.488722E-01 5 1.042E+00 2.504E+01 1.000E+00 9.600E-01 1.943E-02 3.144E-01 3.3386E-01 7.161529E-01 6 1.562E+00 2.556E+01 1.500E+00 9.600E-01 3.394E-02 4.716E-01 5.0558E-01 6.031575E-01 7 2.083E+00 2.608E+01 2.000E+00 9.600E-01 4.891E-02 6.289E-01 6.7776E-01 5.077525E-01 8 3.125E+00 2.712E+01 3.000E+00 9.600E-01 7.914E-02 9.433E-01 1.0224E+00 3.597220E-01 9 4.167E+00 2.817E+01 4.000E+00 9.600E-01 1.094E-01 1.258E+00 1.3671E+00 2.548337E-01 10 5.208E+00 2.921E+01 5.000E+00 9.600E-01 1.397E-01 1.572E+00 1.7119E+00 1.805281E-01 11 6.250E+00 3.025E+01 6.000E+00 9.600E-01 1.700E-01 1.887E+00 2.0566E+00 1.278888E-01 12 7.292E+00 3.129E+01 7.000E+00 9.600E-01 2.003E-01 2.201E+00 2.4013E+00 9.059834E-02 13 8.333E+00 3.233E+01 8.000E+00 9.600E-01 2.306E-01 2.515E+00 2.7460E+00 6.418122E-02 14 9.375E+00 3.338E+01 9.000E+00 9.600E-01 2.609E-01 2.830E+00 3.0908E+00 4.546694E-02 15 1.042E+01 3.442E+01 1.000E+01 9.600E-01 2.912E-01 3.144E+00 3.4355E+00 3.220946E-02 16 1.302E+01 3.702E+01 1.250E+01 9.600E-01 3.670E-01 3.930E+00 4.2973E+00 1.360513E-02 17 1.562E+01 3.962E+01 1.500E+01 9.600E-01 4.427E-01 4.716E+00 5.1591E+00 5.746748E-03 18 1.823E+01 4.223E+01 1.750E+01 9.600E-01 5.185E-01 5.502E+00 6.0209E+00 2.427401E-03 19 2.083E+01 4.483E+01 2.000E+01 9.600E-01 5.942E-01 6.289E+00 6.8827E+00 1.025323E-03 20 2.604E+01 5.004E+01 2.500E+01 9.600E-01 7.457E-01 7.861E+00 8.6064E+00 1.829361E-04 21 3.125E+01 5.525E+01 3.000E+01 9.600E-01 8.972E-01 9.433E+00 1.0330E+01 3.263910E-05 22 3.646E+01 6.046E+01 3.500E+01 9.600E-01 1.049E+00 1.100E+01 1.2054E+01 5.823403E-06 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 2.193E-02 2.402E+01 1.000E-01 4.560E+00 3.832E-04 3.144E-02 3.1826E-02 9.686752E-01 25 5.482E-02 2.405E+01 2.500E-01 4.560E+00 2.330E-03 7.861E-02 8.0936E-02 9.222524E-01 26 1.096E-01 2.411E+01 5.000E-01 4.560E+00 8.906E-03 1.572E-01 1.6612E-01 8.469449E-01 27 2.193E-01 2.422E+01 1.000E+00 4.560E+00 3.265E-02 3.144E-01 3.4707E-01 7.067535E-01 28 3.289E-01 2.433E+01 1.500E+00 4.560E+00 6.759E-02 4.716E-01 5.3923E-01 5.831990E-01 29 4.386E-01 2.444E+01 2.000E+00 4.560E+00 1.110E-01 6.289E-01 7.3984E-01 4.771921E-01 30 6.579E-01 2.466E+01 3.000E+00 4.560E+00 2.154E-01 9.433E-01 1.1586E+00 3.139111E-01 31 8.772E-01 2.488E+01 4.000E+00 4.560E+00 3.346E-01 1.258E+00 1.5923E+00 2.034561E-01 32 1.096E+00 2.510E+01 5.000E+00 4.560E+00 4.623E-01 1.572E+00 2.0344E+00 1.307547E-01 33 1.316E+00 2.532E+01 6.000E+00 4.560E+00 5.948E-01 1.887E+00 2.4814E+00 8.362716E-02 34 1.535E+00 2.554E+01 7.000E+00 4.560E+00 7.301E-01 2.201E+00 2.9311E+00 5.333860E-02 35 1.754E+00 2.575E+01 8.000E+00 4.560E+00 8.670E-01 2.515E+00 3.3824E+00 3.396676E-02 36 1.974E+00 2.597E+01 9.000E+00 4.560E+00 1.005E+00 2.830E+00 3.8345E+00 2.161115E-02 37 2.193E+00 2.619E+01 1.000E+01 4.560E+00 1.143E+00 3.144E+00 4.2872E+00 1.374295E-02 38 2.741E+00 2.674E+01 1.250E+01 4.560E+00 1.490E+00 3.930E+00 5.4200E+00 4.427353E-03 39 3.289E+00 2.729E+01 1.500E+01 4.560E+00 1.837E+00 4.716E+00 6.5532E+00 1.425562E-03 40 3.838E+00 2.784E+01 1.750E+01 4.560E+00 2.184E+00 5.502E+00 7.6865E+00 4.589589E-04 41 4.386E+00 2.839E+01 2.000E+01 4.560E+00 2.531E+00 6.289E+00 8.8199E+00 1.477570E-04 42 5.482E+00 2.948E+01 2.500E+01 4.560E+00 3.226E+00 7.861E+00 1.1087E+01 1.531401E-05 43 6.579E+00 3.058E+01 3.000E+01 4.560E+00 3.921E+00 9.433E+00 1.3354E+01 1.587189E-06 44 7.675E+00 3.168E+01 3.500E+01 4.560E+00 4.615E+00 1.100E+01 1.5620E+01 1.645008E-07 45 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 46 1.111E-03 2.400E+01 1.000E-01 9.000E+01 3.897E-04 3.144E-02 3.1832E-02 9.686689E-01 47 2.778E-03 2.400E+01 2.500E-01 9.000E+01 2.429E-03 7.861E-02 8.1036E-02 9.221604E-01 48 5.556E-03 2.401E+01 5.000E-01 9.000E+01 9.676E-03 1.572E-01 1.6689E-01 8.462935E-01 49 1.111E-02 2.401E+01 1.000E+00 9.000E+01 3.837E-02 3.144E-01 3.5280E-01 7.027197E-01 50 1.667E-02 2.402E+01 1.500E+00 9.000E+01 8.560E-02 4.716E-01 5.5724E-01 5.727898E-01 51 2.222E-02 2.402E+01 2.000E+00 9.000E+01 1.509E-01 6.289E-01 7.7973E-01 4.585286E-01 52 3.333E-02 2.403E+01 3.000E+00 9.000E+01 3.338E-01 9.433E-01 1.2771E+00 2.788542E-01 53 4.444E-02 2.404E+01 4.000E+00 9.000E+01 5.836E-01 1.258E+00 1.8413E+00 1.586166E-01 54 5.556E-02 2.406E+01 5.000E+00 9.000E+01 8.969E-01 1.572E+00 2.4690E+00 8.467011E-02 55 6.667E-02 2.407E+01 6.000E+00 9.000E+01 1.271E+00 1.887E+00 3.1571E+00 4.254934E-02 56 7.778E-02 2.408E+01 7.000E+00 9.000E+01 1.702E+00 2.201E+00 3.9026E+00 2.018985E-02 57 8.889E-02 2.409E+01 8.000E+00 9.000E+01 2.187E+00 2.515E+00 4.7026E+00 9.071478E-03 58 1.000E-01 2.410E+01 9.000E+00 9.000E+01 2.725E+00 2.830E+00 5.5546E+00 3.869807E-03 59 1.111E-01 2.411E+01 1.000E+01 9.000E+01 3.312E+00 3.144E+00 6.4558E+00 1.571330E-03 60 1.389E-01 2.414E+01 1.250E+01 9.000E+01 4.979E+00 3.930E+00 8.9095E+00 1.350984E-04 61 1.667E-01 2.417E+01 1.500E+01 9.000E+01 6.906E+00 4.716E+00 1.1623E+01 8.960029E-06 62 1.944E-01 2.419E+01 1.750E+01 9.000E+01 9.063E+00 5.502E+00 1.4566E+01 4.723626E-07 63 2.222E-01 2.422E+01 2.000E+01 9.000E+01 1.142E+01 6.289E+00 1.7712E+01 2.032319E-08 64 2.778E-01 2.428E+01 2.500E+01 9.000E+01 1.666E+01 7.861E+00 2.4523E+01 2.237388E-11 65 3.333E-01 2.433E+01 3.000E+01 9.000E+01 2.247E+01 9.433E+00 3.1903E+01 1.395095E-14 66 3.889E-01 2.439E+01 3.500E+01 9.000E+01 2.873E+01 1.100E+01 3.9731E+01 5.557224E-18 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 1.004E+00 1.000E-01 9.600E-01 9.6870E-01 9.6870E-01 1.0000E+00 9.6870E-01 9.6870E-01 9.6870E-01 3 1.011E+00 2.500E-01 9.600E-01 9.2257E-01 9.2257E-01 1.0000E+00 9.2257E-01 9.2257E-01 9.2257E-01 4 1.022E+00 5.000E-01 9.600E-01 8.4887E-01 8.4887E-01 1.0000E+00 8.4887E-01 8.4887E-01 8.4887E-01 5 1.043E+00 1.000E+00 9.600E-01 7.1615E-01 7.1615E-01 1.0000E+00 7.1615E-01 7.1615E-01 7.1615E-01 6 1.065E+00 1.500E+00 9.600E-01 6.0316E-01 6.0316E-01 1.0000E+00 6.0316E-01 6.0316E-01 6.0316E-01 7 1.087E+00 2.000E+00 9.600E-01 5.0775E-01 5.0775E-01 1.0000E+00 5.0775E-01 5.0775E-01 5.0775E-01 8 1.130E+00 3.000E+00 9.600E-01 3.5972E-01 3.5972E-01 1.0000E+00 3.5972E-01 3.5972E-01 3.5972E-01 9 1.174E+00 4.000E+00 9.600E-01 2.5483E-01 2.5483E-01 1.0000E+00 2.5483E-01 2.5483E-01 2.5483E-01 10 1.217E+00 5.000E+00 9.600E-01 1.8053E-01 1.8053E-01 1.0000E+00 1.8053E-01 1.8053E-01 1.8053E-01 11 1.260E+00 6.000E+00 9.600E-01 1.2789E-01 1.2789E-01 1.0000E+00 1.2789E-01 1.2789E-01 1.2789E-01 12 1.304E+00 7.000E+00 9.600E-01 9.0598E-02 9.0598E-02 1.0000E+00 9.0598E-02 9.0598E-02 9.0598E-02 13 1.347E+00 8.000E+00 9.600E-01 6.4181E-02 6.4181E-02 1.0000E+00 6.4181E-02 6.4181E-02 6.4181E-02 14 1.391E+00 9.000E+00 9.600E-01 4.5467E-02 4.5467E-02 1.0000E+00 4.5467E-02 4.5467E-02 4.5467E-02 15 1.434E+00 1.000E+01 9.600E-01 3.2209E-02 3.2209E-02 1.0000E+00 3.2209E-02 3.2209E-02 3.2209E-02 16 1.543E+00 1.250E+01 9.600E-01 1.3605E-02 1.3605E-02 1.0000E+00 1.3605E-02 1.3605E-02 1.3605E-02 17 1.651E+00 1.500E+01 9.600E-01 5.7467E-03 5.7467E-03 1.0000E+00 5.7467E-03 5.7467E-03 5.7467E-03 18 1.760E+00 1.750E+01 9.600E-01 2.4274E-03 2.4274E-03 1.0000E+00 2.4274E-03 2.4274E-03 2.4274E-03 19 1.868E+00 2.000E+01 9.600E-01 1.0253E-03 1.0253E-03 1.0000E+00 1.0253E-03 1.0253E-03 1.0253E-03 20 2.085E+00 2.500E+01 9.600E-01 1.8294E-04 1.8294E-04 1.0000E+00 1.8294E-04 1.8294E-04 1.8294E-04 21 2.302E+00 3.000E+01 9.600E-01 3.2639E-05 3.2639E-05 1.0000E+00 3.2639E-05 3.2639E-05 3.2639E-05 22 2.519E+00 3.500E+01 9.600E-01 5.8234E-06 5.8234E-06 1.0000E+00 5.8234E-06 5.8234E-06 5.8234E-06 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 1.001E+00 1.000E-01 4.560E+00 9.6868E-01 9.6868E-01 1.0000E+00 9.6868E-01 9.6868E-01 9.6868E-01 25 1.002E+00 2.500E-01 4.560E+00 9.2225E-01 9.2225E-01 1.0000E+00 9.2225E-01 9.2225E-01 9.2225E-01 26 1.005E+00 5.000E-01 4.560E+00 8.4694E-01 8.4694E-01 1.0000E+00 8.4694E-01 8.4694E-01 8.4694E-01 27 1.009E+00 1.000E+00 4.560E+00 7.0675E-01 7.0675E-01 1.0000E+00 7.0675E-01 7.0675E-01 7.0675E-01 28 1.014E+00 1.500E+00 4.560E+00 5.8320E-01 5.8320E-01 1.0000E+00 5.8320E-01 5.8320E-01 5.8320E-01 29 1.018E+00 2.000E+00 4.560E+00 4.7719E-01 4.7719E-01 1.0000E+00 4.7719E-01 4.7719E-01 4.7719E-01 30 1.027E+00 3.000E+00 4.560E+00 3.1391E-01 3.1391E-01 1.0000E+00 3.1391E-01 3.1391E-01 3.1391E-01 31 1.037E+00 4.000E+00 4.560E+00 2.0346E-01 2.0346E-01 1.0000E+00 2.0346E-01 2.0346E-01 2.0346E-01 32 1.046E+00 5.000E+00 4.560E+00 1.3075E-01 1.3075E-01 1.0000E+00 1.3075E-01 1.3075E-01 1.3075E-01 33 1.055E+00 6.000E+00 4.560E+00 8.3627E-02 8.3627E-02 1.0000E+00 8.3627E-02 8.3627E-02 8.3627E-02 34 1.064E+00 7.000E+00 4.560E+00 5.3339E-02 5.3339E-02 1.0000E+00 5.3339E-02 5.3339E-02 5.3339E-02 35 1.073E+00 8.000E+00 4.560E+00 3.3967E-02 3.3967E-02 1.0000E+00 3.3967E-02 3.3967E-02 3.3967E-02 36 1.082E+00 9.000E+00 4.560E+00 2.1611E-02 2.1611E-02 1.0000E+00 2.1611E-02 2.1611E-02 2.1611E-02 37 1.091E+00 1.000E+01 4.560E+00 1.3743E-02 1.3743E-02 1.0000E+00 1.3743E-02 1.3743E-02 1.3743E-02 38 1.114E+00 1.250E+01 4.560E+00 4.4274E-03 4.4274E-03 1.0000E+00 4.4274E-03 4.4274E-03 4.4274E-03 39 1.137E+00 1.500E+01 4.560E+00 1.4256E-03 1.4256E-03 1.0000E+00 1.4256E-03 1.4256E-03 1.4256E-03 40 1.160E+00 1.750E+01 4.560E+00 4.5896E-04 4.5896E-04 1.0000E+00 4.5896E-04 4.5896E-04 4.5896E-04 41 1.183E+00 2.000E+01 4.560E+00 1.4776E-04 1.4776E-04 1.0000E+00 1.4776E-04 1.4776E-04 1.4776E-04 42 1.228E+00 2.500E+01 4.560E+00 1.5314E-05 1.5314E-05 1.0000E+00 1.5314E-05 1.5314E-05 1.5314E-05 43 1.274E+00 3.000E+01 4.560E+00 1.5872E-06 1.5872E-06 1.0000E+00 1.5872E-06 1.5872E-06 1.5872E-06 44 1.320E+00 3.500E+01 4.560E+00 1.6450E-07 1.6450E-07 1.0000E+00 1.6450E-07 1.6450E-07 1.6450E-07 45 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 46 1.000E+00 1.000E-01 9.000E+01 9.6867E-01 9.6867E-01 1.0000E+00 9.6867E-01 9.6867E-01 9.6867E-01 47 1.000E+00 2.500E-01 9.000E+01 9.2216E-01 9.2216E-01 1.0000E+00 9.2216E-01 9.2216E-01 9.2216E-01 48 1.000E+00 5.000E-01 9.000E+01 8.4629E-01 8.4629E-01 1.0000E+00 8.4629E-01 8.4629E-01 8.4629E-01 49 1.000E+00 1.000E+00 9.000E+01 7.0272E-01 7.0272E-01 1.0000E+00 7.0272E-01 7.0272E-01 7.0272E-01 50 1.001E+00 1.500E+00 9.000E+01 5.7279E-01 5.7279E-01 1.0000E+00 5.7279E-01 5.7279E-01 5.7279E-01 51 1.001E+00 2.000E+00 9.000E+01 4.5853E-01 4.5853E-01 1.0000E+00 4.5853E-01 4.5853E-01 4.5853E-01 52 1.001E+00 3.000E+00 9.000E+01 2.7885E-01 2.7885E-01 1.0000E+00 2.7885E-01 2.7885E-01 2.7885E-01 53 1.002E+00 4.000E+00 9.000E+01 1.5862E-01 1.5862E-01 1.0000E+00 1.5862E-01 1.5862E-01 1.5862E-01 54 1.002E+00 5.000E+00 9.000E+01 8.4670E-02 8.4670E-02 1.0000E+00 8.4670E-02 8.4670E-02 8.4670E-02 55 1.003E+00 6.000E+00 9.000E+01 4.2549E-02 4.2549E-02 1.0000E+00 4.2549E-02 4.2549E-02 4.2549E-02 56 1.003E+00 7.000E+00 9.000E+01 2.0190E-02 2.0190E-02 1.0000E+00 2.0190E-02 2.0190E-02 2.0190E-02 57 1.004E+00 8.000E+00 9.000E+01 9.0715E-03 9.0715E-03 1.0000E+00 9.0715E-03 9.0715E-03 9.0715E-03 58 1.004E+00 9.000E+00 9.000E+01 3.8698E-03 3.8698E-03 1.0000E+00 3.8698E-03 3.8698E-03 3.8698E-03 59 1.005E+00 1.000E+01 9.000E+01 1.5713E-03 1.5713E-03 1.0000E+00 1.5713E-03 1.5713E-03 1.5713E-03 60 1.006E+00 1.250E+01 9.000E+01 1.3510E-04 1.3510E-04 1.0000E+00 1.3510E-04 1.3510E-04 1.3510E-04 61 1.007E+00 1.500E+01 9.000E+01 8.9600E-06 8.9600E-06 1.0000E+00 8.9600E-06 8.9600E-06 8.9600E-06 62 1.008E+00 1.750E+01 9.000E+01 4.7236E-07 4.7236E-07 1.0000E+00 4.7236E-07 4.7236E-07 4.7236E-07 63 1.009E+00 2.000E+01 9.000E+01 2.0323E-08 2.0323E-08 1.0000E+00 2.0323E-08 2.0323E-08 2.0323E-08 64 1.012E+00 2.500E+01 9.000E+01 2.2374E-11 2.2374E-11 1.0000E+00 2.2374E-11 2.2374E-11 2.2374E-11 65 1.014E+00 3.000E+01 9.000E+01 1.3951E-14 1.3951E-14 1.0000E+00 1.3951E-14 1.3951E-14 1.3951E-14 66 1.016E+00 3.500E+01 9.000E+01 5.5572E-18 5.5572E-18 1.0000E+00 5.5572E-18 5.5572E-18 5.5572E-18 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 9.600E-01 1.260E-01 0.00E+00 1.26005E-01 5.188E-07 5.188E-07 5.355E-07 3 2.500E-01 9.600E-01 3.181E-01 0.00E+00 3.18074E-01 1.247E-06 1.247E-06 1.352E-06 4 5.000E-01 9.600E-01 6.436E-01 0.00E+00 6.43573E-01 2.322E-06 2.322E-06 2.735E-06 5 1.000E+00 9.600E-01 1.304E+00 0.00E+00 1.30442E+00 3.970E-06 3.970E-06 5.544E-06 6 1.500E+00 9.600E-01 1.970E+00 0.00E+00 1.97002E+00 5.050E-06 5.050E-06 8.373E-06 7 2.000E+00 9.600E-01 2.637E+00 0.00E+00 2.63694E+00 5.690E-06 5.690E-06 1.121E-05 8 3.000E+00 9.600E-01 3.972E+00 0.00E+00 3.97160E+00 6.072E-06 6.072E-06 1.688E-05 9 4.000E+00 9.600E-01 5.306E+00 0.00E+00 5.30642E+00 5.747E-06 5.747E-06 2.255E-05 10 5.000E+00 9.600E-01 6.641E+00 0.00E+00 6.64126E+00 5.095E-06 5.095E-06 2.822E-05 11 6.000E+00 9.600E-01 7.976E+00 0.00E+00 7.97609E+00 4.335E-06 4.335E-06 3.390E-05 12 7.000E+00 9.600E-01 9.311E+00 0.00E+00 9.31093E+00 3.585E-06 3.585E-06 3.957E-05 13 8.000E+00 9.600E-01 1.065E+01 0.00E+00 1.06458E+01 2.904E-06 2.904E-06 4.524E-05 14 9.000E+00 9.600E-01 1.198E+01 0.00E+00 1.19806E+01 2.315E-06 2.315E-06 5.092E-05 15 1.000E+01 9.600E-01 1.332E+01 0.00E+00 1.33154E+01 1.823E-06 1.823E-06 5.659E-05 16 1.250E+01 9.600E-01 1.665E+01 0.00E+00 1.66525E+01 9.628E-07 9.628E-07 7.077E-05 17 1.500E+01 9.600E-01 1.999E+01 0.00E+00 1.99896E+01 4.882E-07 4.882E-07 8.495E-05 18 1.750E+01 9.600E-01 2.333E+01 0.00E+00 2.33267E+01 2.406E-07 2.406E-07 9.913E-05 19 2.000E+01 9.600E-01 2.666E+01 0.00E+00 2.66638E+01 1.162E-07 1.162E-07 1.133E-04 20 2.500E+01 9.600E-01 3.334E+01 0.00E+00 3.33380E+01 2.592E-08 2.592E-08 1.417E-04 21 3.000E+01 9.600E-01 4.001E+01 0.00E+00 4.00121E+01 5.550E-09 5.550E-09 1.700E-04 22 3.500E+01 9.600E-01 4.669E+01 0.00E+00 4.66863E+01 1.155E-09 1.155E-09 1.984E-04 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 4.560E+00 1.261E-01 0.00E+00 1.26073E-01 5.190E-07 5.190E-07 5.358E-07 25 2.500E-01 4.560E+00 3.190E-01 0.00E+00 3.19023E-01 1.250E-06 1.250E-06 1.356E-06 26 5.000E-01 4.560E+00 6.499E-01 0.00E+00 6.49938E-01 2.339E-06 2.339E-06 2.762E-06 27 1.000E+00 4.560E+00 1.341E+00 0.00E+00 1.34141E+00 4.029E-06 4.029E-06 5.701E-06 28 1.500E+00 4.560E+00 2.064E+00 0.00E+00 2.06424E+00 5.116E-06 5.116E-06 8.773E-06 29 2.000E+00 4.560E+00 2.811E+00 0.00E+00 2.81075E+00 5.700E-06 5.700E-06 1.195E-05 30 3.000E+00 4.560E+00 4.353E+00 0.00E+00 4.35302E+00 5.807E-06 5.807E-06 1.850E-05 31 4.000E+00 4.560E+00 5.937E+00 0.00E+00 5.93687E+00 5.133E-06 5.133E-06 2.523E-05 32 5.000E+00 4.560E+00 7.544E+00 0.00E+00 7.54443E+00 4.192E-06 4.192E-06 3.206E-05 33 6.000E+00 4.560E+00 9.166E+00 0.00E+00 9.16551E+00 3.258E-06 3.258E-06 3.895E-05 34 7.000E+00 4.560E+00 1.079E+01 0.00E+00 1.07943E+01 2.447E-06 2.447E-06 4.587E-05 35 8.000E+00 4.560E+00 1.243E+01 0.00E+00 1.24275E+01 1.794E-06 1.794E-06 5.282E-05 36 9.000E+00 4.560E+00 1.406E+01 0.00E+00 1.40632E+01 1.292E-06 1.292E-06 5.977E-05 37 1.000E+01 4.560E+00 1.570E+01 0.00E+00 1.57003E+01 9.170E-07 9.170E-07 6.672E-05 38 1.250E+01 4.560E+00 1.980E+01 0.00E+00 1.97959E+01 3.725E-07 3.725E-07 8.413E-05 39 1.500E+01 4.560E+00 2.389E+01 0.00E+00 2.38930E+01 1.448E-07 1.448E-07 1.015E-04 40 1.750E+01 4.560E+00 2.799E+01 0.00E+00 2.79904E+01 5.459E-08 5.459E-08 1.190E-04 41 2.000E+01 4.560E+00 3.209E+01 0.00E+00 3.20879E+01 2.015E-08 2.015E-08 1.364E-04 42 2.500E+01 4.560E+00 4.028E+01 0.00E+00 4.02830E+01 2.622E-09 2.622E-09 1.712E-04 43 3.000E+01 4.560E+00 4.848E+01 0.00E+00 4.84781E+01 3.270E-10 3.270E-10 2.060E-04 44 3.500E+01 4.560E+00 5.667E+01 0.00E+00 5.66732E+01 3.962E-11 3.962E-11 2.408E-04 45 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 46 1.000E-01 9.000E+01 1.261E-01 0.00E+00 1.26091E-01 5.191E-07 5.191E-07 5.359E-07 47 2.500E-01 9.000E+01 3.193E-01 0.00E+00 3.19302E-01 1.251E-06 1.251E-06 1.357E-06 48 5.000E-01 9.000E+01 6.521E-01 0.00E+00 6.52092E-01 2.345E-06 2.345E-06 2.771E-06 49 1.000E+00 9.000E+01 1.357E+00 0.00E+00 1.35744E+00 4.054E-06 4.054E-06 5.769E-06 50 1.500E+00 9.000E+01 2.115E+00 0.00E+00 2.11467E+00 5.148E-06 5.148E-06 8.987E-06 51 2.000E+00 9.000E+01 2.922E+00 0.00E+00 2.92246E+00 5.695E-06 5.695E-06 1.242E-05 52 3.000E+00 9.000E+01 4.685E+00 0.00E+00 4.68460E+00 5.552E-06 5.552E-06 1.991E-05 53 4.000E+00 9.000E+01 6.634E+00 0.00E+00 6.63396E+00 4.472E-06 4.472E-06 2.819E-05 54 5.000E+00 9.000E+01 8.761E+00 0.00E+00 8.76120E+00 3.153E-06 3.153E-06 3.723E-05 55 6.000E+00 9.000E+01 1.106E+01 0.00E+00 1.10575E+01 2.000E-06 2.000E-06 4.699E-05 56 7.000E+00 9.000E+01 1.351E+01 0.00E+00 1.35144E+01 1.160E-06 1.160E-06 5.743E-05 57 8.000E+00 9.000E+01 1.612E+01 0.00E+00 1.61242E+01 6.216E-07 6.216E-07 6.853E-05 58 9.000E+00 9.000E+01 1.888E+01 0.00E+00 1.88792E+01 3.105E-07 3.105E-07 8.023E-05 59 1.000E+01 9.000E+01 2.177E+01 0.00E+00 2.17724E+01 1.454E-07 1.454E-07 9.253E-05 60 1.250E+01 9.000E+01 2.957E+01 0.00E+00 2.95667E+01 1.698E-08 1.698E-08 1.257E-04 61 1.500E+01 9.000E+01 3.809E+01 0.00E+00 3.80877E+01 1.450E-09 1.450E-09 1.619E-04 62 1.750E+01 9.000E+01 4.725E+01 0.00E+00 4.72515E+01 9.485E-11 9.485E-11 2.008E-04 63 2.000E+01 9.000E+01 5.698E+01 0.00E+00 5.69843E+01 4.921E-12 4.921E-12 2.422E-04 64 2.500E+01 9.000E+01 7.790E+01 0.00E+00 7.79049E+01 7.407E-15 7.407E-15 3.310E-04 65 3.000E+01 9.000E+01 1.004E+02 0.00E+00 1.00417E+02 5.953E-18 5.953E-18 4.267E-04 66 3.500E+01 9.000E+01 1.242E+02 0.00E+00 1.24184E+02 2.932E-21 2.932E-21 5.276E-04 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 9.600E-01 1.260E-01 5.188E-07 5.355E-07 6.8995E-05 6.9002E-05 6.6842E-05 3 2.500E-01 9.600E-01 3.181E-01 1.247E-06 1.352E-06 6.8995E-05 6.9011E-05 6.3667E-05 4 5.000E-01 9.600E-01 6.436E-01 2.322E-06 2.735E-06 6.8995E-05 6.9028E-05 5.8596E-05 5 1.000E+00 9.600E-01 1.304E+00 3.970E-06 5.544E-06 6.8995E-05 6.9061E-05 4.9458E-05 6 1.500E+00 9.600E-01 1.970E+00 5.050E-06 8.373E-06 6.8995E-05 6.9095E-05 4.1675E-05 7 2.000E+00 9.600E-01 2.637E+00 5.690E-06 1.121E-05 6.8994E-05 6.9128E-05 3.5100E-05 8 3.000E+00 9.600E-01 3.972E+00 6.072E-06 1.688E-05 6.8994E-05 6.9195E-05 2.4891E-05 9 4.000E+00 9.600E-01 5.306E+00 5.747E-06 2.255E-05 6.8994E-05 6.9263E-05 1.7650E-05 10 5.000E+00 9.600E-01 6.641E+00 5.095E-06 2.822E-05 6.8993E-05 6.9330E-05 1.2516E-05 11 6.000E+00 9.600E-01 7.976E+00 4.335E-06 3.390E-05 6.8993E-05 6.9397E-05 8.8751E-06 12 7.000E+00 9.600E-01 9.311E+00 3.585E-06 3.957E-05 6.8992E-05 6.9464E-05 6.2934E-06 13 8.000E+00 9.600E-01 1.065E+01 2.904E-06 4.524E-05 6.8992E-05 6.9532E-05 4.4626E-06 14 9.000E+00 9.600E-01 1.198E+01 2.315E-06 5.092E-05 6.8992E-05 6.9599E-05 3.1645E-06 15 1.000E+01 9.600E-01 1.332E+01 1.823E-06 5.659E-05 6.8991E-05 6.9666E-05 2.2439E-06 16 1.250E+01 9.600E-01 1.665E+01 9.628E-07 7.077E-05 6.8990E-05 6.9835E-05 9.5011E-07 17 1.500E+01 9.600E-01 1.999E+01 4.882E-07 8.495E-05 6.8989E-05 7.0003E-05 4.0229E-07 18 1.750E+01 9.600E-01 2.333E+01 2.406E-07 9.913E-05 6.8988E-05 7.0171E-05 1.7033E-07 19 2.000E+01 9.600E-01 2.666E+01 1.162E-07 1.133E-04 6.8987E-05 7.0339E-05 7.2120E-08 20 2.500E+01 9.600E-01 3.334E+01 2.592E-08 1.417E-04 6.8985E-05 7.0675E-05 1.2929E-08 21 3.000E+01 9.600E-01 4.001E+01 5.550E-09 1.700E-04 6.8983E-05 7.1012E-05 2.3178E-09 22 3.500E+01 9.600E-01 4.669E+01 1.155E-09 1.984E-04 6.8982E-05 7.1348E-05 4.1549E-10 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 4.560E+00 1.261E-01 5.190E-07 5.358E-07 6.8995E-05 6.9002E-05 6.6840E-05 25 2.500E-01 4.560E+00 3.190E-01 1.250E-06 1.356E-06 6.8995E-05 6.9011E-05 6.3646E-05 26 5.000E-01 4.560E+00 6.499E-01 2.339E-06 2.762E-06 6.8995E-05 6.9028E-05 5.8463E-05 27 1.000E+00 4.560E+00 1.341E+00 4.029E-06 5.701E-06 6.8995E-05 6.9063E-05 4.8810E-05 28 1.500E+00 4.560E+00 2.064E+00 5.116E-06 8.773E-06 6.8995E-05 6.9099E-05 4.0299E-05 29 2.000E+00 4.560E+00 2.811E+00 5.700E-06 1.195E-05 6.8994E-05 6.9137E-05 3.2992E-05 30 3.000E+00 4.560E+00 4.353E+00 5.807E-06 1.850E-05 6.8994E-05 6.9215E-05 2.1727E-05 31 4.000E+00 4.560E+00 5.937E+00 5.133E-06 2.523E-05 6.8993E-05 6.9294E-05 1.4098E-05 32 5.000E+00 4.560E+00 7.544E+00 4.192E-06 3.206E-05 6.8993E-05 6.9375E-05 9.0712E-06 33 6.000E+00 4.560E+00 9.166E+00 3.258E-06 3.895E-05 6.8993E-05 6.9457E-05 5.8085E-06 34 7.000E+00 4.560E+00 1.079E+01 2.447E-06 4.587E-05 6.8992E-05 6.9539E-05 3.7091E-06 35 8.000E+00 4.560E+00 1.243E+01 1.794E-06 5.282E-05 6.8992E-05 6.9622E-05 2.3648E-06 36 9.000E+00 4.560E+00 1.406E+01 1.292E-06 5.977E-05 6.8991E-05 6.9704E-05 1.5064E-06 37 1.000E+01 4.560E+00 1.570E+01 9.170E-07 6.672E-05 6.8991E-05 6.9787E-05 9.5907E-07 38 1.250E+01 4.560E+00 1.980E+01 3.725E-07 8.413E-05 6.8989E-05 6.9993E-05 3.0988E-07 39 1.500E+01 4.560E+00 2.389E+01 1.448E-07 1.015E-04 6.8988E-05 7.0199E-05 1.0007E-07 40 1.750E+01 4.560E+00 2.799E+01 5.459E-08 1.190E-04 6.8987E-05 7.0406E-05 3.2313E-08 41 2.000E+01 4.560E+00 3.209E+01 2.015E-08 1.364E-04 6.8986E-05 7.0612E-05 1.0433E-08 42 2.500E+01 4.560E+00 4.028E+01 2.622E-09 1.712E-04 6.8983E-05 7.1025E-05 1.0877E-09 43 3.000E+01 4.560E+00 4.848E+01 3.270E-10 2.060E-04 6.8981E-05 7.1438E-05 1.1339E-10 44 3.500E+01 4.560E+00 5.667E+01 3.962E-11 2.408E-04 6.8979E-05 7.1851E-05 1.1820E-11 45 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 46 1.000E-01 9.000E+01 1.261E-01 5.191E-07 5.359E-07 6.8995E-05 6.9002E-05 6.6840E-05 47 2.500E-01 9.000E+01 3.193E-01 1.251E-06 1.357E-06 6.8995E-05 6.9011E-05 6.3639E-05 48 5.000E-01 9.000E+01 6.521E-01 2.345E-06 2.771E-06 6.8995E-05 6.9028E-05 5.8418E-05 49 1.000E+00 9.000E+01 1.357E+00 4.054E-06 5.769E-06 6.8995E-05 6.9064E-05 4.8532E-05 50 1.500E+00 9.000E+01 2.115E+00 5.148E-06 8.987E-06 6.8995E-05 6.9102E-05 3.9581E-05 51 2.000E+00 9.000E+01 2.922E+00 5.695E-06 1.242E-05 6.8994E-05 6.9143E-05 3.1704E-05 52 3.000E+00 9.000E+01 4.685E+00 5.552E-06 1.991E-05 6.8994E-05 6.9231E-05 1.9305E-05 53 4.000E+00 9.000E+01 6.634E+00 4.472E-06 2.819E-05 6.8993E-05 6.9330E-05 1.0997E-05 54 5.000E+00 9.000E+01 8.761E+00 3.153E-06 3.723E-05 6.8993E-05 6.9437E-05 5.8792E-06 55 6.000E+00 9.000E+01 1.106E+01 2.000E-06 4.699E-05 6.8992E-05 6.9553E-05 2.9594E-06 56 7.000E+00 9.000E+01 1.351E+01 1.160E-06 5.743E-05 6.8991E-05 6.9676E-05 1.4068E-06 57 8.000E+00 9.000E+01 1.612E+01 6.216E-07 6.853E-05 6.8990E-05 6.9808E-05 6.3326E-07 58 9.000E+00 9.000E+01 1.888E+01 3.105E-07 8.023E-05 6.8990E-05 6.9947E-05 2.7068E-07 59 1.000E+01 9.000E+01 2.177E+01 1.454E-07 9.253E-05 6.8989E-05 7.0093E-05 1.1014E-07 60 1.250E+01 9.000E+01 2.957E+01 1.698E-08 1.257E-04 6.8987E-05 7.0485E-05 9.5225E-09 61 1.500E+01 9.000E+01 3.809E+01 1.450E-09 1.619E-04 6.8984E-05 7.0915E-05 6.3540E-10 62 1.750E+01 9.000E+01 4.725E+01 9.485E-11 2.008E-04 6.8981E-05 7.1377E-05 3.3716E-11 63 2.000E+01 9.000E+01 5.698E+01 4.921E-12 2.422E-04 6.8979E-05 7.1867E-05 1.4606E-12 64 2.500E+01 9.000E+01 7.790E+01 7.407E-15 3.310E-04 6.8972E-05 7.2921E-05 1.6315E-15 65 3.000E+01 9.000E+01 1.004E+02 5.953E-18 4.267E-04 6.8966E-05 7.4055E-05 1.0331E-18 66 3.500E+01 9.000E+01 1.242E+02 2.932E-21 5.276E-04 6.8959E-05 7.5253E-05 4.1820E-22 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency LPLM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.314 (1/Gy), alpha/beta = 8.054 (Gy), lamda = 2.450E+00 (1/h). ====================================================================================================== --- Duration (h) --- Dose Dose Rate* ***** G FACTOR ***** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL GEFF SF1 SF2 ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 1.042E-01 2.410E+01 1.000E-01 9.600E-01 9.201E-01 9.194E-01 9.6870E-01 9.686988E-01 3 2.604E-01 2.426E+01 2.500E-01 9.600E-01 8.173E-01 8.158E-01 9.2256E-01 9.225651E-01 4 5.208E-01 2.452E+01 5.000E-01 9.600E-01 6.819E-01 6.796E-01 8.4885E-01 8.488722E-01 5 1.042E+00 2.504E+01 1.000E+00 9.600E-01 5.005E-01 4.978E-01 7.1608E-01 7.161529E-01 6 1.562E+00 2.556E+01 1.500E+00 9.600E-01 3.889E-01 3.863E-01 6.0302E-01 6.031575E-01 7 2.083E+00 2.608E+01 2.000E+00 9.600E-01 3.155E-01 3.132E-01 5.0757E-01 5.077525E-01 8 3.125E+00 2.712E+01 3.000E+00 9.600E-01 2.271E-01 2.252E-01 3.5949E-01 3.597220E-01 9 4.167E+00 2.817E+01 4.000E+00 9.600E-01 1.767E-01 1.752E-01 2.5459E-01 2.548337E-01 10 5.208E+00 2.921E+01 5.000E+00 9.600E-01 1.445E-01 1.432E-01 1.8030E-01 1.805281E-01 11 6.250E+00 3.025E+01 6.000E+00 9.600E-01 1.221E-01 1.210E-01 1.2769E-01 1.278888E-01 12 7.292E+00 3.129E+01 7.000E+00 9.600E-01 1.057E-01 1.047E-01 9.0432E-02 9.059834E-02 13 8.333E+00 3.233E+01 8.000E+00 9.600E-01 9.316E-02 9.231E-02 6.4044E-02 6.418122E-02 14 9.375E+00 3.338E+01 9.000E+00 9.600E-01 8.328E-02 8.251E-02 4.5356E-02 4.546694E-02 15 1.042E+01 3.442E+01 1.000E+01 9.600E-01 7.530E-02 7.460E-02 3.2122E-02 3.220946E-02 16 1.302E+01 3.702E+01 1.250E+01 9.600E-01 6.073E-02 6.016E-02 1.3558E-02 1.360513E-02 17 1.562E+01 3.962E+01 1.500E+01 9.600E-01 5.088E-02 5.040E-02 5.7226E-03 5.746748E-03 18 1.823E+01 4.223E+01 1.750E+01 9.600E-01 4.378E-02 4.336E-02 2.4154E-03 2.427401E-03 19 2.083E+01 4.483E+01 2.000E+01 9.600E-01 3.842E-02 3.805E-02 1.0195E-03 1.025323E-03 20 2.604E+01 5.004E+01 2.500E+01 9.600E-01 3.086E-02 3.056E-02 1.8163E-04 1.829361E-04 21 3.125E+01 5.525E+01 3.000E+01 9.600E-01 2.578E-02 2.553E-02 3.2358E-05 3.263910E-05 22 3.646E+01 6.046E+01 3.500E+01 9.600E-01 2.214E-02 2.193E-02 5.7647E-06 5.823403E-06 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 2.193E-02 2.402E+01 1.000E-01 4.560E+00 9.823E-01 9.815E-01 9.6867E-01 9.686752E-01 25 5.482E-02 2.405E+01 2.500E-01 4.560E+00 9.567E-01 9.547E-01 9.2225E-01 9.222524E-01 26 1.096E-01 2.411E+01 5.000E-01 4.560E+00 9.162E-01 9.125E-01 8.4691E-01 8.469449E-01 27 2.193E-01 2.422E+01 1.000E+00 4.560E+00 8.426E-01 8.362E-01 7.0658E-01 7.067535E-01 28 3.289E-01 2.433E+01 1.500E+00 4.560E+00 7.778E-01 7.694E-01 5.8277E-01 5.831990E-01 29 4.386E-01 2.444E+01 2.000E+00 4.560E+00 7.206E-01 7.107E-01 4.7646E-01 4.771921E-01 30 6.579E-01 2.466E+01 3.000E+00 4.560E+00 6.246E-01 6.129E-01 3.1263E-01 3.139111E-01 31 8.772E-01 2.488E+01 4.000E+00 4.560E+00 5.481E-01 5.357E-01 2.0189E-01 2.034561E-01 32 1.096E+00 2.510E+01 5.000E+00 4.560E+00 4.862E-01 4.737E-01 1.2916E-01 1.307547E-01 33 1.316E+00 2.532E+01 6.000E+00 4.560E+00 4.356E-01 4.232E-01 8.2184E-02 8.362716E-02 34 1.535E+00 2.554E+01 7.000E+00 4.560E+00 3.937E-01 3.817E-01 5.2127E-02 5.333860E-02 35 1.754E+00 2.575E+01 8.000E+00 4.560E+00 3.585E-01 3.470E-01 3.3002E-02 3.396676E-02 36 1.974E+00 2.597E+01 9.000E+00 4.560E+00 3.287E-01 3.177E-01 2.0870E-02 2.161115E-02 37 2.193E+00 2.619E+01 1.000E+01 4.560E+00 3.033E-01 2.928E-01 1.3190E-02 1.374295E-02 38 2.741E+00 2.674E+01 1.250E+01 4.560E+00 2.535E-01 2.442E-01 4.1830E-03 4.427353E-03 39 3.289E+00 2.729E+01 1.500E+01 4.560E+00 2.174E-01 2.091E-01 1.3256E-03 1.425562E-03 40 3.838E+00 2.784E+01 1.750E+01 4.560E+00 1.901E-01 1.827E-01 4.2004E-04 4.589589E-04 41 4.386E+00 2.839E+01 2.000E+01 4.560E+00 1.688E-01 1.621E-01 1.3308E-04 1.477570E-04 42 5.482E+00 2.948E+01 2.500E+01 4.560E+00 1.378E-01 1.322E-01 1.3360E-05 1.531401E-05 43 6.579E+00 3.058E+01 3.000E+01 4.560E+00 1.164E-01 1.116E-01 1.3411E-06 1.587189E-06 44 7.675E+00 3.168E+01 3.500E+01 4.560E+00 1.007E-01 9.651E-02 1.3463E-07 1.645008E-07 45 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 46 1.111E-03 2.400E+01 1.000E-01 9.000E+01 9.991E-01 9.983E-01 9.6867E-01 9.686689E-01 47 2.778E-03 2.400E+01 2.500E-01 9.000E+01 9.977E-01 9.957E-01 9.2216E-01 9.221604E-01 48 5.556E-03 2.401E+01 5.000E-01 9.000E+01 9.955E-01 9.914E-01 8.4626E-01 8.462935E-01 49 1.111E-02 2.401E+01 1.000E+00 9.000E+01 9.910E-01 9.828E-01 7.0250E-01 7.027197E-01 50 1.667E-02 2.402E+01 1.500E+00 9.000E+01 9.865E-01 9.745E-01 5.7218E-01 5.727898E-01 51 2.222E-02 2.402E+01 2.000E+00 9.000E+01 9.821E-01 9.662E-01 4.5739E-01 4.585286E-01 52 3.333E-02 2.403E+01 3.000E+00 9.000E+01 9.733E-01 9.500E-01 2.7658E-01 2.788542E-01 53 4.444E-02 2.404E+01 4.000E+00 9.000E+01 9.647E-01 9.342E-01 1.5563E-01 1.586166E-01 54 5.556E-02 2.406E+01 5.000E+00 9.000E+01 9.561E-01 9.189E-01 8.1649E-02 8.467011E-02 55 6.667E-02 2.407E+01 6.000E+00 9.000E+01 9.477E-01 9.040E-01 4.0015E-02 4.254934E-02 56 7.778E-02 2.408E+01 7.000E+00 9.000E+01 9.394E-01 8.895E-01 1.8352E-02 2.018985E-02 57 8.889E-02 2.409E+01 8.000E+00 9.000E+01 9.312E-01 8.754E-01 7.8908E-03 9.071478E-03 58 1.000E-01 2.410E+01 9.000E+00 9.000E+01 9.231E-01 8.616E-01 3.1863E-03 3.869807E-03 59 1.111E-01 2.411E+01 1.000E+01 9.000E+01 9.151E-01 8.482E-01 1.2103E-03 1.571330E-03 60 1.389E-01 2.414E+01 1.250E+01 9.000E+01 8.956E-01 8.163E-01 8.3263E-05 1.350984E-04 61 1.667E-01 2.417E+01 1.500E+01 9.000E+01 8.767E-01 7.862E-01 4.0470E-06 8.960029E-06 62 1.944E-01 2.419E+01 1.750E+01 9.000E+01 8.584E-01 7.580E-01 1.4219E-07 4.723626E-07 63 2.222E-01 2.422E+01 2.000E+01 9.000E+01 8.408E-01 7.315E-01 3.6894E-09 2.032319E-08 64 2.778E-01 2.428E+01 2.500E+01 9.000E+01 8.070E-01 6.829E-01 1.0819E-12 2.237388E-11 65 3.333E-01 2.433E+01 3.000E+01 9.000E+01 7.754E-01 6.395E-01 1.1790E-16 1.395095E-14 66 3.889E-01 2.439E+01 3.500E+01 9.000E+01 7.456E-01 6.007E-01 5.4159E-21 5.557224E-18 ------------------------------------------------------------------------------------------------------ GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/D)/(beta*D). In the formula for GEFF, SF is surviving fraction as computed using the LPL model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL. The SF estimates are: SF1=EXP{-dose*[alpha+gl*beta*dose]} and SF2=EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 1.004E+00 1.000E-01 9.6870E-01 9.6870E-01 9.6870E-01 3.7958E-01 3.7958E-01 3.7958E-01 3.7958E-01 3 1.011E+00 2.500E-01 9.2257E-01 9.2257E-01 9.2257E-01 3.9750E-01 3.9750E-01 3.9750E-01 3.9750E-01 4 1.022E+00 5.000E-01 8.4887E-01 8.4887E-01 8.4887E-01 4.2790E-01 4.2790E-01 4.2790E-01 4.2790E-01 5 1.043E+00 1.000E+00 7.1615E-01 7.1615E-01 7.1615E-01 4.8863E-01 4.8863E-01 4.8863E-01 4.8863E-01 6 1.065E+00 1.500E+00 6.0316E-01 6.0316E-01 6.0316E-01 5.4708E-01 5.4708E-01 5.4708E-01 5.4708E-01 7 1.087E+00 2.000E+00 5.0775E-01 5.0775E-01 5.0775E-01 6.0185E-01 6.0185E-01 6.0185E-01 6.0185E-01 8 1.130E+00 3.000E+00 3.5972E-01 3.5972E-01 3.5972E-01 6.9787E-01 6.9787E-01 6.9787E-01 6.9787E-01 9 1.174E+00 4.000E+00 2.5483E-01 2.5483E-01 2.5483E-01 7.7505E-01 7.7505E-01 7.7505E-01 7.7505E-01 10 1.217E+00 5.000E+00 1.8053E-01 1.8053E-01 1.8053E-01 8.3483E-01 8.3483E-01 8.3483E-01 8.3483E-01 11 1.260E+00 6.000E+00 1.2789E-01 1.2789E-01 1.2789E-01 8.7995E-01 8.7995E-01 8.7995E-01 8.7995E-01 12 1.304E+00 7.000E+00 9.0598E-02 9.0598E-02 9.0598E-02 9.1338E-01 9.1338E-01 9.1338E-01 9.1338E-01 13 1.347E+00 8.000E+00 6.4181E-02 6.4181E-02 6.4181E-02 9.3784E-01 9.3784E-01 9.3784E-01 9.3784E-01 14 1.391E+00 9.000E+00 4.5467E-02 4.5467E-02 4.5467E-02 9.5555E-01 9.5555E-01 9.5555E-01 9.5555E-01 15 1.434E+00 1.000E+01 3.2209E-02 3.2209E-02 3.2209E-02 9.6830E-01 9.6830E-01 9.6830E-01 9.6830E-01 16 1.543E+00 1.250E+01 1.3605E-02 1.3605E-02 1.3605E-02 9.8649E-01 9.8649E-01 9.8649E-01 9.8649E-01 17 1.651E+00 1.500E+01 5.7467E-03 5.7467E-03 5.7467E-03 9.9427E-01 9.9427E-01 9.9427E-01 9.9427E-01 18 1.760E+00 1.750E+01 2.4274E-03 2.4274E-03 2.4274E-03 9.9758E-01 9.9758E-01 9.9758E-01 9.9758E-01 19 1.868E+00 2.000E+01 1.0253E-03 1.0253E-03 1.0253E-03 9.9898E-01 9.9898E-01 9.9898E-01 9.9898E-01 20 2.085E+00 2.500E+01 1.8294E-04 1.8294E-04 1.8294E-04 9.9982E-01 9.9982E-01 9.9982E-01 9.9982E-01 21 2.302E+00 3.000E+01 3.2639E-05 3.2639E-05 3.2639E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 22 2.519E+00 3.500E+01 5.8234E-06 5.8234E-06 5.8234E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 1.001E+00 1.000E-01 9.6868E-01 9.6868E-01 9.6868E-01 3.7959E-01 3.7959E-01 3.7959E-01 3.7959E-01 25 1.002E+00 2.500E-01 9.2225E-01 9.2225E-01 9.2225E-01 3.9762E-01 3.9762E-01 3.9762E-01 3.9762E-01 26 1.005E+00 5.000E-01 8.4694E-01 8.4694E-01 8.4694E-01 4.2872E-01 4.2872E-01 4.2872E-01 4.2872E-01 27 1.009E+00 1.000E+00 7.0675E-01 7.0675E-01 7.0675E-01 4.9324E-01 4.9324E-01 4.9324E-01 4.9324E-01 28 1.014E+00 1.500E+00 5.8320E-01 5.8320E-01 5.8320E-01 5.5811E-01 5.5811E-01 5.5811E-01 5.5811E-01 29 1.018E+00 2.000E+00 4.7719E-01 4.7719E-01 4.7719E-01 6.2052E-01 6.2052E-01 6.2052E-01 6.2052E-01 30 1.027E+00 3.000E+00 3.1391E-01 3.1391E-01 3.1391E-01 7.3058E-01 7.3058E-01 7.3058E-01 7.3058E-01 31 1.037E+00 4.000E+00 2.0346E-01 2.0346E-01 2.0346E-01 8.1591E-01 8.1591E-01 8.1591E-01 8.1591E-01 32 1.046E+00 5.000E+00 1.3075E-01 1.3075E-01 1.3075E-01 8.7743E-01 8.7743E-01 8.7743E-01 8.7743E-01 33 1.055E+00 6.000E+00 8.3627E-02 8.3627E-02 8.3627E-02 9.1977E-01 9.1977E-01 9.1977E-01 9.1977E-01 34 1.064E+00 7.000E+00 5.3339E-02 5.3339E-02 5.3339E-02 9.4806E-01 9.4806E-01 9.4806E-01 9.4806E-01 35 1.073E+00 8.000E+00 3.3967E-02 3.3967E-02 3.3967E-02 9.6660E-01 9.6660E-01 9.6660E-01 9.6660E-01 36 1.082E+00 9.000E+00 2.1611E-02 2.1611E-02 2.1611E-02 9.7862E-01 9.7862E-01 9.7862E-01 9.7862E-01 37 1.091E+00 1.000E+01 1.3743E-02 1.3743E-02 1.3743E-02 9.8635E-01 9.8635E-01 9.8635E-01 9.8635E-01 38 1.114E+00 1.250E+01 4.4274E-03 4.4274E-03 4.4274E-03 9.9558E-01 9.9558E-01 9.9558E-01 9.9558E-01 39 1.137E+00 1.500E+01 1.4256E-03 1.4256E-03 1.4256E-03 9.9858E-01 9.9858E-01 9.9858E-01 9.9858E-01 40 1.160E+00 1.750E+01 4.5896E-04 4.5896E-04 4.5896E-04 9.9954E-01 9.9954E-01 9.9954E-01 9.9954E-01 41 1.183E+00 2.000E+01 1.4776E-04 1.4776E-04 1.4776E-04 9.9985E-01 9.9985E-01 9.9985E-01 9.9985E-01 42 1.228E+00 2.500E+01 1.5314E-05 1.5314E-05 1.5314E-05 9.9998E-01 9.9998E-01 9.9998E-01 9.9998E-01 43 1.274E+00 3.000E+01 1.5872E-06 1.5872E-06 1.5872E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 1.320E+00 3.500E+01 1.6450E-07 1.6450E-07 1.6450E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 45 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 46 1.000E+00 1.000E-01 9.6867E-01 9.6867E-01 9.6867E-01 3.7959E-01 3.7959E-01 3.7959E-01 3.7959E-01 47 1.000E+00 2.500E-01 9.2216E-01 9.2216E-01 9.2216E-01 3.9766E-01 3.9766E-01 3.9766E-01 3.9766E-01 48 1.000E+00 5.000E-01 8.4629E-01 8.4629E-01 8.4629E-01 4.2900E-01 4.2900E-01 4.2900E-01 4.2900E-01 49 1.000E+00 1.000E+00 7.0272E-01 7.0272E-01 7.0272E-01 4.9524E-01 4.9524E-01 4.9524E-01 4.9524E-01 50 1.001E+00 1.500E+00 5.7279E-01 5.7279E-01 5.7279E-01 5.6395E-01 5.6395E-01 5.6395E-01 5.6395E-01 51 1.001E+00 2.000E+00 4.5853E-01 4.5853E-01 4.5853E-01 6.3221E-01 6.3221E-01 6.3221E-01 6.3221E-01 52 1.001E+00 3.000E+00 2.7885E-01 2.7885E-01 2.7885E-01 7.5665E-01 7.5665E-01 7.5665E-01 7.5665E-01 53 1.002E+00 4.000E+00 1.5862E-01 1.5862E-01 1.5862E-01 8.5332E-01 8.5332E-01 8.5332E-01 8.5332E-01 54 1.002E+00 5.000E+00 8.4670E-02 8.4670E-02 8.4670E-02 9.1882E-01 9.1882E-01 9.1882E-01 9.1882E-01 55 1.003E+00 6.000E+00 4.2549E-02 4.2549E-02 4.2549E-02 9.5834E-01 9.5834E-01 9.5834E-01 9.5834E-01 56 1.003E+00 7.000E+00 2.0190E-02 2.0190E-02 2.0190E-02 9.8001E-01 9.8001E-01 9.8001E-01 9.8001E-01 57 1.004E+00 8.000E+00 9.0715E-03 9.0715E-03 9.0715E-03 9.9097E-01 9.9097E-01 9.9097E-01 9.9097E-01 58 1.004E+00 9.000E+00 3.8698E-03 3.8698E-03 3.8698E-03 9.9614E-01 9.9614E-01 9.9614E-01 9.9614E-01 59 1.005E+00 1.000E+01 1.5713E-03 1.5713E-03 1.5713E-03 9.9843E-01 9.9843E-01 9.9843E-01 9.9843E-01 60 1.006E+00 1.250E+01 1.3510E-04 1.3510E-04 1.3510E-04 9.9986E-01 9.9986E-01 9.9986E-01 9.9986E-01 61 1.007E+00 1.500E+01 8.9600E-06 8.9600E-06 8.9600E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 62 1.008E+00 1.750E+01 4.7236E-07 4.7236E-07 4.7236E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 63 1.009E+00 2.000E+01 2.0323E-08 2.0323E-08 2.0323E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 64 1.012E+00 2.500E+01 2.2374E-11 2.2374E-11 2.2374E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 65 1.014E+00 3.000E+01 1.3951E-14 1.3951E-14 1.3951E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 66 1.016E+00 3.500E+01 5.5572E-18 5.5572E-18 5.5572E-18 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 1.042E-01 4.340E-03 0.0000E+00 1.0000E-01 0.0000E+00 9.6000E-01 3 2.604E-01 1.085E-02 0.0000E+00 2.5000E-01 0.0000E+00 9.6000E-01 4 5.208E-01 2.170E-02 0.0000E+00 5.0000E-01 0.0000E+00 9.6000E-01 5 1.042E+00 4.340E-02 0.0000E+00 1.0000E+00 0.0000E+00 9.6000E-01 6 1.562E+00 6.510E-02 0.0000E+00 1.5000E+00 0.0000E+00 9.6000E-01 7 2.083E+00 8.681E-02 0.0000E+00 2.0000E+00 0.0000E+00 9.6000E-01 8 3.125E+00 1.302E-01 0.0000E+00 3.0000E+00 0.0000E+00 9.6000E-01 9 4.167E+00 1.736E-01 0.0000E+00 4.0000E+00 0.0000E+00 9.6000E-01 10 5.208E+00 2.170E-01 0.0000E+00 5.0000E+00 0.0000E+00 9.6000E-01 11 6.250E+00 2.604E-01 0.0000E+00 6.0000E+00 0.0000E+00 9.6000E-01 12 7.292E+00 3.038E-01 0.0000E+00 7.0000E+00 0.0000E+00 9.6000E-01 13 8.333E+00 3.472E-01 0.0000E+00 8.0000E+00 0.0000E+00 9.6000E-01 14 9.375E+00 3.906E-01 0.0000E+00 9.0000E+00 0.0000E+00 9.6000E-01 15 1.042E+01 4.340E-01 0.0000E+00 1.0000E+01 0.0000E+00 9.6000E-01 16 1.302E+01 5.425E-01 0.0000E+00 1.2500E+01 0.0000E+00 9.6000E-01 17 1.562E+01 6.510E-01 0.0000E+00 1.5000E+01 0.0000E+00 9.6000E-01 18 1.823E+01 7.595E-01 0.0000E+00 1.7500E+01 0.0000E+00 9.6000E-01 19 2.083E+01 8.681E-01 0.0000E+00 2.0000E+01 0.0000E+00 9.6000E-01 20 2.604E+01 1.085E+00 0.0000E+00 2.5000E+01 0.0000E+00 9.6000E-01 21 3.125E+01 1.302E+00 0.0000E+00 3.0000E+01 0.0000E+00 9.6000E-01 22 3.646E+01 1.519E+00 0.0000E+00 3.5000E+01 0.0000E+00 9.6000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 2.193E-02 9.137E-04 0.0000E+00 1.0000E-01 0.0000E+00 4.5600E+00 25 5.482E-02 2.284E-03 0.0000E+00 2.5000E-01 0.0000E+00 4.5600E+00 26 1.096E-01 4.569E-03 0.0000E+00 5.0000E-01 0.0000E+00 4.5600E+00 27 2.193E-01 9.137E-03 0.0000E+00 1.0000E+00 0.0000E+00 4.5600E+00 28 3.289E-01 1.371E-02 0.0000E+00 1.5000E+00 0.0000E+00 4.5600E+00 29 4.386E-01 1.827E-02 0.0000E+00 2.0000E+00 0.0000E+00 4.5600E+00 30 6.579E-01 2.741E-02 0.0000E+00 3.0000E+00 0.0000E+00 4.5600E+00 31 8.772E-01 3.655E-02 0.0000E+00 4.0000E+00 0.0000E+00 4.5600E+00 32 1.096E+00 4.569E-02 0.0000E+00 5.0000E+00 0.0000E+00 4.5600E+00 33 1.316E+00 5.482E-02 0.0000E+00 6.0000E+00 0.0000E+00 4.5600E+00 34 1.535E+00 6.396E-02 0.0000E+00 7.0000E+00 0.0000E+00 4.5600E+00 35 1.754E+00 7.310E-02 0.0000E+00 8.0000E+00 0.0000E+00 4.5600E+00 36 1.974E+00 8.224E-02 0.0000E+00 9.0000E+00 0.0000E+00 4.5600E+00 37 2.193E+00 9.137E-02 0.0000E+00 1.0000E+01 0.0000E+00 4.5600E+00 38 2.741E+00 1.142E-01 0.0000E+00 1.2500E+01 0.0000E+00 4.5600E+00 39 3.289E+00 1.371E-01 0.0000E+00 1.5000E+01 0.0000E+00 4.5600E+00 40 3.838E+00 1.599E-01 0.0000E+00 1.7500E+01 0.0000E+00 4.5600E+00 41 4.386E+00 1.827E-01 0.0000E+00 2.0000E+01 0.0000E+00 4.5600E+00 42 5.482E+00 2.284E-01 0.0000E+00 2.5000E+01 0.0000E+00 4.5600E+00 43 6.579E+00 2.741E-01 0.0000E+00 3.0000E+01 0.0000E+00 4.5600E+00 44 7.675E+00 3.198E-01 0.0000E+00 3.5000E+01 0.0000E+00 4.5600E+00 45 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 46 1.111E-03 4.630E-05 0.0000E+00 1.0000E-01 0.0000E+00 9.0000E+01 47 2.778E-03 1.157E-04 0.0000E+00 2.5000E-01 0.0000E+00 9.0000E+01 48 5.556E-03 2.315E-04 0.0000E+00 5.0000E-01 0.0000E+00 9.0000E+01 49 1.111E-02 4.630E-04 0.0000E+00 1.0000E+00 0.0000E+00 9.0000E+01 50 1.667E-02 6.944E-04 0.0000E+00 1.5000E+00 0.0000E+00 9.0000E+01 51 2.222E-02 9.259E-04 0.0000E+00 2.0000E+00 0.0000E+00 9.0000E+01 52 3.333E-02 1.389E-03 0.0000E+00 3.0000E+00 0.0000E+00 9.0000E+01 53 4.444E-02 1.852E-03 0.0000E+00 4.0000E+00 0.0000E+00 9.0000E+01 54 5.556E-02 2.315E-03 0.0000E+00 5.0000E+00 0.0000E+00 9.0000E+01 55 6.667E-02 2.778E-03 0.0000E+00 6.0000E+00 0.0000E+00 9.0000E+01 56 7.778E-02 3.241E-03 0.0000E+00 7.0000E+00 0.0000E+00 9.0000E+01 57 8.889E-02 3.704E-03 0.0000E+00 8.0000E+00 0.0000E+00 9.0000E+01 58 1.000E-01 4.167E-03 0.0000E+00 9.0000E+00 0.0000E+00 9.0000E+01 59 1.111E-01 4.630E-03 0.0000E+00 1.0000E+01 0.0000E+00 9.0000E+01 60 1.389E-01 5.787E-03 0.0000E+00 1.2500E+01 0.0000E+00 9.0000E+01 61 1.667E-01 6.944E-03 0.0000E+00 1.5000E+01 0.0000E+00 9.0000E+01 62 1.944E-01 8.102E-03 0.0000E+00 1.7500E+01 0.0000E+00 9.0000E+01 63 2.222E-01 9.259E-03 0.0000E+00 2.0000E+01 0.0000E+00 9.0000E+01 64 2.778E-01 1.157E-02 0.0000E+00 2.5000E+01 0.0000E+00 9.0000E+01 65 3.333E-01 1.389E-02 0.0000E+00 3.0000E+01 0.0000E+00 9.0000E+01 66 3.889E-01 1.620E-02 0.0000E+00 3.5000E+01 0.0000E+00 9.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 5.71667E-03 VC 2.00G 05-JUL-2003 23-JUL-2003 02:31:23 PM