TLK input file used to
generate fit Human Bladder Carcinoma Cells |
*/ MODEL: DRM=TLK CKM=QECK CELL: DNA=5.667D+09 NC=46 IRAD: CL=DSB CLRP: RHT=HT4R BMR=2.75E-04 PHI=PML A0=PMR CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1 RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data ! TLK model inputs (simple and complex double strand breaks) DSB = 20 5 / !Radiation damage to DNA HT4R = 0.25 7 / !Half-times for DSB repair PML = 0.01 / !Probability a misrejoined DSB is lethal PMR = 0.75 0.25 / !Probability DSB is rejoined correctly ! Parameters that impact on solution accuracy SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10 ! Parameters that control the time steps and stopping criteria SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09 BCONF: MITR=10000 MXFN=100000 SGT=1.0D-04 SST=1.0D-09 FCT=1.0D-09 MCAT: NPAR=4 !npar=2 or 3 for small datasets, npar=3-5 for large datasets AMP1: CID=CLRP PNAM=BMR PLB=0.0 PUB=1.0D-02 PIG=2.0E-04 AMP2: CID=CLRP PNAM=PHI PLB=0.0 PUB=0.25 PIG=0.01 LI=0 !Both DSB AMP3: CID=CLRP PNAM=RHT PLB=0.01 PUB=12 PIG=0.15 LI=1 !Simple DSB AMP4: CID=CLRP PNAM=RHT PLB=0.01 PUB=12 PIG=8 LI=2 !Complex DSB AMP5: CID=IRAD PNAM=CL PLB=1 PUB=20.0 PIG=5 LI=2 !Complex DSB /* Figure of Merit (FOM) Weight 1: cell survival data 2: DSB rejoining data (FAR) 3: DSB rejoining data (Avg. DSB/cell) 4: Transformed cells per survivor 5: Transformed cells per irradiated cell */ FOM: UW=LFWT LFWT = 1 0 0 0 0 / |
|
School
of Health Sciences Purdue University Disclaimer |
Last updated:
10 June, 2011
|