VC 2.00I 15-JUL-2003 02-AUG-2003 07:32:30 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\ht144\tlk\ht144.inp FNI: U:\archive\ht144\tlk\ht144.inp FNO: U:\archive\ht144\tlk\ht144.out RADX: U:\archive\ht144\tlk\ht144.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 12.00000 h Potential doubling time (Tpot): 1008.00000 h (= 42.000 days) Cell birth rate (AX): 1.3863E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.3698E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 1.6504E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 1.93802E-11 1.19111E-02 67.500000 Complex DSB = 6.46006E-12 3.97035E-03 22.500000 Total DSB = 2.58403E-11 1.58814E-02 90.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 3.297468E-02 (=3.297%) PHI2= 3.297468E-02 (=3.297%) (1-A1)*PHI1= 8.243670E-03 (=0.824%) (1-A2)*PHI2= 2.473101E-02 (=2.473%) (1-A1)*(1-PHI1)= 2.417563E-01 (=24.176%) (1-A2)*(1-PHI2)= 7.252690E-01 (=72.527%) RHT1= 0.001000 h (=0.06 minute) RHT2= 0.001000 h (=0.06 minute) LAM1= 6.9314718E+02 (1/h) LAM2= 6.9314718E+02 (1/h) BMR= 2.4665271E+00 (1/h) LAM1/BMR= 2.8102151E+02 LAM2/BMR= 2.8102151E+02 (LAM1+LAM2)/BMR= 5.6204303E+02 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 5.5645E-01 + 5.5645E-01 = 1.1128955E+00 (1/Gy) beta: 2.5908E+00 + 8.3390E-01 = 3.4247189E+00 (1/Gy^2) alpha/beta: 0.3249597 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 1.894E-01 2.419E+01 1.000E-01 5.280E-01 1.118E-01 1.356E-37 1.1181E-01 8.942168E-01 3 4.735E-01 2.447E+01 2.500E-01 5.280E-01 2.795E-01 1.104E-37 2.7952E-01 7.561439E-01 4 9.470E-01 2.495E+01 5.000E-01 5.280E-01 5.591E-01 6.664E-38 5.5905E-01 5.717513E-01 5 1.894E+00 2.589E+01 1.000E+00 5.280E-01 1.118E+00 6.883E-38 1.1181E+00 3.268982E-01 6 2.841E+00 2.684E+01 1.500E+00 5.280E-01 1.677E+00 1.211E-37 1.6772E+00 1.869037E-01 7 3.788E+00 2.779E+01 2.000E+00 5.280E-01 2.236E+00 1.060E-37 2.2362E+00 1.068620E-01 8 5.682E+00 2.968E+01 3.000E+00 5.280E-01 3.354E+00 8.276E-38 3.3543E+00 3.493286E-02 9 7.576E+00 3.158E+01 4.000E+00 5.280E-01 4.472E+00 6.883E-38 4.4724E+00 1.141944E-02 10 9.470E+00 3.347E+01 5.000E+00 5.280E-01 5.591E+00 1.134E-37 5.5905E+00 3.732981E-03 11 1.136E+01 3.536E+01 6.000E+00 5.280E-01 6.709E+00 1.107E-37 6.7087E+00 1.220300E-03 12 1.326E+01 3.726E+01 7.000E+00 5.280E-01 7.827E+00 1.134E-37 7.8268E+00 3.989122E-04 13 1.515E+01 3.915E+01 8.000E+00 5.280E-01 8.945E+00 1.119E-37 8.9449E+00 1.304032E-04 14 1.705E+01 4.105E+01 9.000E+00 5.280E-01 1.006E+01 1.246E-37 1.0063E+01 4.262839E-05 15 1.894E+01 4.294E+01 1.000E+01 5.280E-01 1.118E+01 1.274E-37 1.1181E+01 1.393509E-05 16 2.367E+01 4.767E+01 1.250E+01 5.280E-01 1.398E+01 1.274E-37 1.3976E+01 8.514061E-07 17 2.841E+01 5.241E+01 1.500E+01 5.280E-01 1.677E+01 1.060E-37 1.6772E+01 5.201921E-08 18 3.314E+01 5.714E+01 1.750E+01 5.280E-01 1.957E+01 1.274E-37 1.9567E+01 3.178270E-09 19 3.788E+01 6.188E+01 2.000E+01 5.280E-01 2.236E+01 1.274E-37 2.2362E+01 1.941859E-10 20 4.735E+01 7.135E+01 2.500E+01 5.280E-01 2.795E+01 6.547E-38 2.7953E+01 7.248894E-13 21 5.682E+01 8.082E+01 3.000E+01 5.280E-01 3.354E+01 1.274E-37 3.3543E+01 2.705987E-15 22 6.629E+01 9.029E+01 3.500E+01 5.280E-01 3.913E+01 6.546E-38 3.9134E+01 1.010136E-17 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.488E-03 2.400E+01 1.000E-01 6.720E+01 1.358E-01 0.000E+00 1.3583E-01 8.729945E-01 25 3.720E-03 2.400E+01 2.500E-01 6.720E+01 3.812E-01 1.075E-33 3.8118E-01 6.830526E-01 26 7.440E-03 2.401E+01 5.000E-01 6.720E+01 8.124E-01 0.000E+00 8.1237E-01 4.438030E-01 27 1.488E-02 2.401E+01 1.000E+00 6.720E+01 1.681E+00 0.000E+00 1.6815E+00 1.861019E-01 28 2.232E-02 2.402E+01 1.500E+00 6.720E+01 2.551E+00 0.000E+00 2.5508E+00 7.802032E-02 29 2.976E-02 2.403E+01 2.000E+00 6.720E+01 3.420E+00 0.000E+00 3.4201E+00 3.270876E-02 30 4.464E-02 2.404E+01 3.000E+00 6.720E+01 5.159E+00 0.000E+00 5.1588E+00 5.748795E-03 31 5.952E-02 2.406E+01 4.000E+00 6.720E+01 6.897E+00 0.000E+00 6.8974E+00 1.010391E-03 32 7.440E-02 2.407E+01 5.000E+00 6.720E+01 8.636E+00 0.000E+00 8.6361E+00 1.775834E-04 33 8.929E-02 2.409E+01 6.000E+00 6.720E+01 1.037E+01 0.000E+00 1.0375E+01 3.121153E-05 34 1.042E-01 2.410E+01 7.000E+00 6.720E+01 1.211E+01 0.000E+00 1.2113E+01 5.485647E-06 35 1.190E-01 2.412E+01 8.000E+00 6.720E+01 1.385E+01 0.000E+00 1.3852E+01 9.641411E-07 36 1.339E-01 2.413E+01 9.000E+00 6.720E+01 1.559E+01 0.000E+00 1.5591E+01 1.694546E-07 37 1.488E-01 2.415E+01 1.000E+01 6.720E+01 1.733E+01 0.000E+00 1.7329E+01 2.978284E-08 38 1.860E-01 2.419E+01 1.250E+01 6.720E+01 2.168E+01 0.000E+00 2.1676E+01 3.856985E-10 39 2.232E-01 2.422E+01 1.500E+01 6.720E+01 2.602E+01 0.000E+00 2.6023E+01 4.994935E-12 40 2.604E-01 2.426E+01 1.750E+01 6.720E+01 3.037E+01 0.000E+00 3.0369E+01 6.468621E-14 41 2.976E-01 2.430E+01 2.000E+01 6.720E+01 3.472E+01 0.000E+00 3.4716E+01 8.377098E-16 42 3.720E-01 2.437E+01 2.500E+01 6.720E+01 4.341E+01 0.000E+00 4.3409E+01 1.404939E-19 43 4.464E-01 2.445E+01 3.000E+01 6.720E+01 5.210E+01 0.000E+00 5.2102E+01 2.356249E-23 44 5.208E-01 2.452E+01 3.500E+01 6.720E+01 6.080E+01 0.000E+00 6.0796E+01 3.951708E-27 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=12.0000 h, Tpot=42.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 1.008E+00 1.000E-01 5.280E-01 8.9422E-01 8.9422E-01 1.0000E+00 8.9422E-01 8.9422E-01 8.9422E-01 3 1.020E+00 2.500E-01 5.280E-01 7.5614E-01 7.5614E-01 1.0000E+00 7.5614E-01 7.5614E-01 7.5614E-01 4 1.039E+00 5.000E-01 5.280E-01 5.7175E-01 5.7175E-01 1.0000E+00 5.7175E-01 5.7175E-01 5.7175E-01 5 1.079E+00 1.000E+00 5.280E-01 3.2690E-01 3.2690E-01 1.0000E+00 3.2690E-01 3.2690E-01 3.2690E-01 6 1.118E+00 1.500E+00 5.280E-01 1.8690E-01 1.8690E-01 1.0000E+00 1.8690E-01 1.8690E-01 1.8690E-01 7 1.158E+00 2.000E+00 5.280E-01 1.0686E-01 1.0686E-01 1.0000E+00 1.0686E-01 1.0686E-01 1.0686E-01 8 1.237E+00 3.000E+00 5.280E-01 3.4933E-02 3.4933E-02 1.0000E+00 3.4933E-02 3.4933E-02 3.4933E-02 9 1.316E+00 4.000E+00 5.280E-01 1.1419E-02 1.1419E-02 1.0000E+00 1.1419E-02 1.1419E-02 1.1419E-02 10 1.395E+00 5.000E+00 5.280E-01 3.7330E-03 3.7330E-03 1.0000E+00 3.7330E-03 3.7330E-03 3.7330E-03 11 1.473E+00 6.000E+00 5.280E-01 1.2203E-03 1.2203E-03 1.0000E+00 1.2203E-03 1.2203E-03 1.2203E-03 12 1.552E+00 7.000E+00 5.280E-01 3.9891E-04 3.9891E-04 1.0000E+00 3.9891E-04 3.9891E-04 3.9891E-04 13 1.631E+00 8.000E+00 5.280E-01 1.3040E-04 1.3040E-04 1.0000E+00 1.3040E-04 1.3040E-04 1.3040E-04 14 1.710E+00 9.000E+00 5.280E-01 4.2628E-05 4.2628E-05 1.0000E+00 4.2628E-05 4.2628E-05 4.2628E-05 15 1.789E+00 1.000E+01 5.280E-01 1.3935E-05 1.3935E-05 1.0000E+00 1.3935E-05 1.3935E-05 1.3935E-05 16 1.986E+00 1.250E+01 5.280E-01 8.5141E-07 8.5141E-07 1.0000E+00 8.5141E-07 8.5141E-07 8.5141E-07 17 2.184E+00 1.500E+01 5.280E-01 5.2019E-08 5.2019E-08 1.0000E+00 5.2019E-08 5.2019E-08 5.2019E-08 18 2.381E+00 1.750E+01 5.280E-01 3.1783E-09 3.1783E-09 1.0000E+00 3.1783E-09 3.1783E-09 3.1783E-09 19 2.578E+00 2.000E+01 5.280E-01 1.9419E-10 1.9419E-10 1.0000E+00 1.9419E-10 1.9419E-10 1.9419E-10 20 2.973E+00 2.500E+01 5.280E-01 7.2489E-13 7.2489E-13 1.0000E+00 7.2489E-13 7.2489E-13 7.2489E-13 21 3.367E+00 3.000E+01 5.280E-01 2.7060E-15 2.7060E-15 1.0000E+00 2.7060E-15 2.7060E-15 2.7060E-15 22 3.762E+00 3.500E+01 5.280E-01 1.0101E-17 1.0101E-17 1.0000E+00 1.0101E-17 1.0101E-17 1.0101E-17 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 1.000E+00 1.000E-01 6.720E+01 8.7299E-01 8.7299E-01 1.0000E+00 8.7299E-01 8.7299E-01 8.7299E-01 25 1.000E+00 2.500E-01 6.720E+01 6.8305E-01 6.8305E-01 1.0000E+00 6.8305E-01 6.8305E-01 6.8305E-01 26 1.000E+00 5.000E-01 6.720E+01 4.4380E-01 4.4380E-01 1.0000E+00 4.4380E-01 4.4380E-01 4.4380E-01 27 1.001E+00 1.000E+00 6.720E+01 1.8610E-01 1.8610E-01 1.0000E+00 1.8610E-01 1.8610E-01 1.8610E-01 28 1.001E+00 1.500E+00 6.720E+01 7.8020E-02 7.8020E-02 1.0000E+00 7.8020E-02 7.8020E-02 7.8020E-02 29 1.001E+00 2.000E+00 6.720E+01 3.2709E-02 3.2709E-02 1.0000E+00 3.2709E-02 3.2709E-02 3.2709E-02 30 1.002E+00 3.000E+00 6.720E+01 5.7488E-03 5.7488E-03 1.0000E+00 5.7488E-03 5.7488E-03 5.7488E-03 31 1.002E+00 4.000E+00 6.720E+01 1.0104E-03 1.0104E-03 1.0000E+00 1.0104E-03 1.0104E-03 1.0104E-03 32 1.003E+00 5.000E+00 6.720E+01 1.7758E-04 1.7758E-04 1.0000E+00 1.7758E-04 1.7758E-04 1.7758E-04 33 1.004E+00 6.000E+00 6.720E+01 3.1212E-05 3.1212E-05 1.0000E+00 3.1212E-05 3.1212E-05 3.1212E-05 34 1.004E+00 7.000E+00 6.720E+01 5.4856E-06 5.4856E-06 1.0000E+00 5.4856E-06 5.4856E-06 5.4856E-06 35 1.005E+00 8.000E+00 6.720E+01 9.6414E-07 9.6414E-07 1.0000E+00 9.6414E-07 9.6414E-07 9.6414E-07 36 1.006E+00 9.000E+00 6.720E+01 1.6945E-07 1.6945E-07 1.0000E+00 1.6945E-07 1.6945E-07 1.6945E-07 37 1.006E+00 1.000E+01 6.720E+01 2.9783E-08 2.9783E-08 1.0000E+00 2.9783E-08 2.9783E-08 2.9783E-08 38 1.008E+00 1.250E+01 6.720E+01 3.8570E-10 3.8570E-10 1.0000E+00 3.8570E-10 3.8570E-10 3.8570E-10 39 1.009E+00 1.500E+01 6.720E+01 4.9949E-12 4.9949E-12 1.0000E+00 4.9949E-12 4.9949E-12 4.9949E-12 40 1.011E+00 1.750E+01 6.720E+01 6.4686E-14 6.4686E-14 1.0000E+00 6.4686E-14 6.4686E-14 6.4686E-14 41 1.012E+00 2.000E+01 6.720E+01 8.3771E-16 8.3771E-16 1.0000E+00 8.3771E-16 8.3771E-16 8.3771E-16 42 1.016E+00 2.500E+01 6.720E+01 1.4049E-19 1.4049E-19 1.0000E+00 1.4049E-19 1.4049E-19 1.4049E-19 43 1.019E+00 3.000E+01 6.720E+01 2.3562E-23 2.3562E-23 1.0000E+00 2.3562E-23 2.3562E-23 2.3562E-23 44 1.022E+00 3.500E+01 6.720E+01 3.9517E-27 3.9517E-27 1.0000E+00 3.9517E-27 3.9517E-27 3.9517E-27 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 5.280E-01 3.265E+00 0.00E+00 3.26455E+00 1.241E-05 1.241E-05 1.387E-05 3 2.500E-01 5.280E-01 8.161E+00 0.00E+00 8.16139E+00 2.623E-05 2.623E-05 3.469E-05 4 5.000E-01 5.280E-01 1.632E+01 0.00E+00 1.63228E+01 3.966E-05 3.966E-05 6.937E-05 5 1.000E+00 5.280E-01 3.265E+01 0.00E+00 3.26456E+01 4.535E-05 4.535E-05 1.387E-04 6 1.500E+00 5.280E-01 4.897E+01 0.00E+00 4.89684E+01 3.889E-05 3.889E-05 2.081E-04 7 2.000E+00 5.280E-01 6.529E+01 0.00E+00 6.52912E+01 2.965E-05 2.965E-05 2.774E-04 8 3.000E+00 5.280E-01 9.794E+01 0.00E+00 9.79368E+01 1.454E-05 1.454E-05 4.161E-04 9 4.000E+00 5.280E-01 1.306E+02 0.00E+00 1.30582E+02 6.336E-06 6.336E-06 5.548E-04 10 5.000E+00 5.280E-01 1.632E+02 0.00E+00 1.63228E+02 2.589E-06 2.589E-06 6.935E-04 11 6.000E+00 5.280E-01 1.959E+02 0.00E+00 1.95874E+02 1.015E-06 1.015E-06 8.321E-04 12 7.000E+00 5.280E-01 2.285E+02 0.00E+00 2.28519E+02 3.872E-07 3.872E-07 9.707E-04 13 8.000E+00 5.280E-01 2.612E+02 0.00E+00 2.61165E+02 1.447E-07 1.447E-07 1.109E-03 14 9.000E+00 5.280E-01 2.938E+02 0.00E+00 2.93810E+02 5.320E-08 5.320E-08 1.248E-03 15 1.000E+01 5.280E-01 3.265E+02 0.00E+00 3.26456E+02 1.932E-08 1.932E-08 1.386E-03 16 1.250E+01 5.280E-01 4.081E+02 0.00E+00 4.08070E+02 1.475E-09 1.475E-09 1.733E-03 17 1.500E+01 5.280E-01 4.897E+02 0.00E+00 4.89684E+02 1.081E-10 1.081E-10 2.079E-03 18 1.750E+01 5.280E-01 5.713E+02 0.00E+00 5.71298E+02 7.708E-12 7.708E-12 2.425E-03 19 2.000E+01 5.280E-01 6.529E+02 0.00E+00 6.52912E+02 5.381E-13 5.381E-13 2.771E-03 20 2.500E+01 5.280E-01 8.161E+02 0.00E+00 8.16140E+02 2.510E-15 2.510E-15 3.463E-03 21 3.000E+01 5.280E-01 9.794E+02 0.00E+00 9.79368E+02 1.124E-17 1.124E-17 4.154E-03 22 3.500E+01 5.280E-01 1.143E+03 0.00E+00 1.14260E+03 4.893E-20 4.893E-20 4.844E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.720E+01 3.304E+00 0.00E+00 3.30371E+00 1.226E-05 1.226E-05 1.404E-05 25 2.500E-01 6.720E+01 8.327E+00 0.00E+00 8.32711E+00 2.417E-05 2.417E-05 3.539E-05 26 5.000E-01 6.720E+01 1.674E+01 0.00E+00 1.67357E+01 3.157E-05 3.157E-05 7.112E-05 27 1.000E+00 6.720E+01 3.356E+01 0.00E+00 3.35639E+01 2.654E-05 2.654E-05 1.426E-04 28 1.500E+00 6.720E+01 5.039E+01 0.00E+00 5.03925E+01 1.671E-05 1.671E-05 2.141E-04 29 2.000E+00 6.720E+01 6.722E+01 0.00E+00 6.72211E+01 9.343E-06 9.343E-06 2.856E-04 30 3.000E+00 6.720E+01 1.009E+02 0.00E+00 1.00878E+02 2.464E-06 2.464E-06 4.286E-04 31 4.000E+00 6.720E+01 1.345E+02 0.00E+00 1.34535E+02 5.776E-07 5.776E-07 5.716E-04 32 5.000E+00 6.720E+01 1.682E+02 0.00E+00 1.68192E+02 1.269E-07 1.269E-07 7.146E-04 33 6.000E+00 6.720E+01 2.018E+02 0.00E+00 2.01850E+02 2.676E-08 2.676E-08 8.575E-04 34 7.000E+00 6.720E+01 2.355E+02 0.00E+00 2.35507E+02 5.488E-09 5.488E-09 1.000E-03 35 8.000E+00 6.720E+01 2.692E+02 0.00E+00 2.69164E+02 1.102E-09 1.102E-09 1.143E-03 36 9.000E+00 6.720E+01 3.028E+02 0.00E+00 3.02821E+02 2.179E-10 2.179E-10 1.286E-03 37 1.000E+01 6.720E+01 3.365E+02 0.00E+00 3.36478E+02 4.256E-11 4.256E-11 1.429E-03 38 1.250E+01 6.720E+01 4.206E+02 0.00E+00 4.20621E+02 6.889E-13 6.889E-13 1.786E-03 39 1.500E+01 6.720E+01 5.048E+02 0.00E+00 5.04764E+02 1.070E-14 1.070E-14 2.143E-03 40 1.750E+01 6.720E+01 5.889E+02 0.00E+00 5.88907E+02 1.617E-16 1.617E-16 2.500E-03 41 2.000E+01 6.720E+01 6.730E+02 0.00E+00 6.73050E+02 2.393E-18 2.393E-18 2.856E-03 42 2.500E+01 6.720E+01 8.413E+02 0.00E+00 8.41335E+02 5.015E-22 5.015E-22 3.569E-03 43 3.000E+01 6.720E+01 1.010E+03 0.00E+00 1.00962E+03 1.009E-25 1.009E-25 4.282E-03 44 3.500E+01 6.720E+01 1.178E+03 0.00E+00 1.17791E+03 1.973E-29 1.973E-29 4.994E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 5.280E-01 3.265E+00 1.241E-05 1.387E-05 6.8994E-05 6.9160E-05 6.1844E-05 3 2.500E-01 5.280E-01 8.161E+00 2.623E-05 3.469E-05 6.8993E-05 6.9407E-05 5.2481E-05 4 5.000E-01 5.280E-01 1.632E+01 3.966E-05 6.937E-05 6.8990E-05 6.9818E-05 3.9918E-05 5 1.000E+00 5.280E-01 3.265E+01 4.535E-05 1.387E-04 6.8986E-05 7.0641E-05 2.3092E-05 6 1.500E+00 5.280E-01 4.897E+01 3.889E-05 2.081E-04 6.8981E-05 7.1463E-05 1.3357E-05 7 2.000E+00 5.280E-01 6.529E+01 2.965E-05 2.774E-04 6.8976E-05 7.2286E-05 7.7246E-06 8 3.000E+00 5.280E-01 9.794E+01 1.454E-05 4.161E-04 6.8967E-05 7.3930E-05 2.5826E-06 9 4.000E+00 5.280E-01 1.306E+02 6.336E-06 5.548E-04 6.8957E-05 7.5575E-05 8.6302E-07 10 5.000E+00 5.280E-01 1.632E+02 2.589E-06 6.935E-04 6.8947E-05 7.7219E-05 2.8826E-07 11 6.000E+00 5.280E-01 1.959E+02 1.015E-06 8.321E-04 6.8938E-05 7.8864E-05 9.6237E-08 12 7.000E+00 5.280E-01 2.285E+02 3.872E-07 9.707E-04 6.8928E-05 8.0507E-05 3.2115E-08 13 8.000E+00 5.280E-01 2.612E+02 1.447E-07 1.109E-03 6.8919E-05 8.2151E-05 1.0713E-08 14 9.000E+00 5.280E-01 2.938E+02 5.320E-08 1.248E-03 6.8909E-05 8.3795E-05 3.5720E-09 15 1.000E+01 5.280E-01 3.265E+02 1.932E-08 1.386E-03 6.8900E-05 8.5438E-05 1.1906E-09 16 1.250E+01 5.280E-01 4.081E+02 1.475E-09 1.733E-03 6.8876E-05 8.9545E-05 7.6239E-11 17 1.500E+01 5.280E-01 4.897E+02 1.081E-10 2.079E-03 6.8852E-05 9.3651E-05 4.8716E-12 18 1.750E+01 5.280E-01 5.713E+02 7.708E-12 2.425E-03 6.8828E-05 9.7755E-05 3.1069E-13 19 2.000E+01 5.280E-01 6.529E+02 5.381E-13 2.771E-03 6.8804E-05 1.0186E-04 1.9779E-14 20 2.500E+01 5.280E-01 8.161E+02 2.510E-15 3.463E-03 6.8756E-05 1.1006E-04 7.9781E-17 21 3.000E+01 5.280E-01 9.794E+02 1.124E-17 4.154E-03 6.8709E-05 1.1825E-04 3.2000E-19 22 3.500E+01 5.280E-01 1.143E+03 4.893E-20 4.844E-03 6.8661E-05 1.2644E-04 1.2773E-21 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.720E+01 3.304E+00 1.226E-05 1.404E-05 6.8994E-05 6.9162E-05 6.0378E-05 25 2.500E-01 6.720E+01 8.327E+00 2.417E-05 3.539E-05 6.8993E-05 6.9415E-05 4.7414E-05 26 5.000E-01 6.720E+01 1.674E+01 3.157E-05 7.112E-05 6.8990E-05 6.9839E-05 3.0995E-05 27 1.000E+00 6.720E+01 3.356E+01 2.654E-05 1.426E-04 6.8985E-05 7.0687E-05 1.3155E-05 28 1.500E+00 6.720E+01 5.039E+01 1.671E-05 2.141E-04 6.8980E-05 7.1535E-05 5.5812E-06 29 2.000E+00 6.720E+01 6.722E+01 9.343E-06 2.856E-04 6.8976E-05 7.2383E-05 2.3676E-06 30 3.000E+00 6.720E+01 1.009E+02 2.464E-06 4.286E-04 6.8966E-05 7.4079E-05 4.2586E-07 31 4.000E+00 6.720E+01 1.345E+02 5.776E-07 5.716E-04 6.8956E-05 7.5774E-05 7.6562E-08 32 5.000E+00 6.720E+01 1.682E+02 1.269E-07 7.146E-04 6.8946E-05 7.7469E-05 1.3757E-08 33 6.000E+00 6.720E+01 2.018E+02 2.676E-08 8.575E-04 6.8936E-05 7.9164E-05 2.4708E-09 34 7.000E+00 6.720E+01 2.355E+02 5.488E-09 1.000E-03 6.8926E-05 8.0859E-05 4.4357E-10 35 8.000E+00 6.720E+01 2.692E+02 1.102E-09 1.143E-03 6.8916E-05 8.2554E-05 7.9594E-11 36 9.000E+00 6.720E+01 3.028E+02 2.179E-10 1.286E-03 6.8906E-05 8.4248E-05 1.4276E-11 37 1.000E+01 6.720E+01 3.365E+02 4.256E-11 1.429E-03 6.8897E-05 8.5942E-05 2.5596E-12 38 1.250E+01 6.720E+01 4.206E+02 6.889E-13 1.786E-03 6.8872E-05 9.0176E-05 3.4781E-14 39 1.500E+01 6.720E+01 5.048E+02 1.070E-14 2.143E-03 6.8847E-05 9.4409E-05 4.7157E-16 40 1.750E+01 6.720E+01 5.889E+02 1.617E-16 2.500E-03 6.8823E-05 9.8640E-05 6.3807E-18 41 2.000E+01 6.720E+01 6.730E+02 2.393E-18 2.856E-03 6.8798E-05 1.0287E-04 8.6175E-20 42 2.500E+01 6.720E+01 8.413E+02 5.015E-22 3.569E-03 6.8749E-05 1.1132E-04 1.5640E-23 43 3.000E+01 6.720E+01 1.010E+03 1.009E-25 4.282E-03 6.8700E-05 1.1977E-04 2.8222E-27 44 3.500E+01 6.720E+01 1.178E+03 1.973E-29 4.994E-03 6.8651E-05 1.2822E-04 5.0667E-31 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 1.1129 (1/Gy), alpha/beta = 0.3250 (Gy), lamda1 = 6.931E+02 (1/h), lamda2 = 6.931E+02 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 1.894E-01 2.419E+01 1.000E-01 5.280E-01 1.512E-02 1.512E-02 1.511E-02 8.9422E-01 8.942168E-01 3 4.735E-01 2.447E+01 2.500E-01 5.280E-01 6.075E-03 6.075E-03 6.072E-03 7.5614E-01 7.561439E-01 4 9.470E-01 2.495E+01 5.000E-01 5.280E-01 3.042E-03 3.042E-03 3.041E-03 5.7175E-01 5.717513E-01 5 1.894E+00 2.589E+01 1.000E+00 5.280E-01 1.522E-03 1.522E-03 1.522E-03 3.2690E-01 3.268982E-01 6 2.841E+00 2.684E+01 1.500E+00 5.280E-01 1.015E-03 1.015E-03 1.015E-03 1.8690E-01 1.869037E-01 7 3.788E+00 2.779E+01 2.000E+00 5.280E-01 7.615E-04 7.615E-04 7.611E-04 1.0686E-01 1.068620E-01 8 5.682E+00 2.968E+01 3.000E+00 5.280E-01 5.077E-04 5.077E-04 5.075E-04 3.4933E-02 3.493286E-02 9 7.576E+00 3.158E+01 4.000E+00 5.280E-01 3.808E-04 3.808E-04 3.806E-04 1.1419E-02 1.141944E-02 10 9.470E+00 3.347E+01 5.000E+00 5.280E-01 3.047E-04 3.047E-04 3.045E-04 3.7329E-03 3.732981E-03 11 1.136E+01 3.536E+01 6.000E+00 5.280E-01 2.539E-04 2.539E-04 2.538E-04 1.2203E-03 1.220300E-03 12 1.326E+01 3.726E+01 7.000E+00 5.280E-01 2.176E-04 2.176E-04 2.175E-04 3.9891E-04 3.989122E-04 13 1.515E+01 3.915E+01 8.000E+00 5.280E-01 1.904E-04 1.904E-04 1.903E-04 1.3040E-04 1.304032E-04 14 1.705E+01 4.105E+01 9.000E+00 5.280E-01 1.693E-04 1.693E-04 1.692E-04 4.2627E-05 4.262839E-05 15 1.894E+01 4.294E+01 1.000E+01 5.280E-01 1.523E-04 1.523E-04 1.523E-04 1.3935E-05 1.393509E-05 16 2.367E+01 4.767E+01 1.250E+01 5.280E-01 1.219E-04 1.219E-04 1.218E-04 8.5138E-07 8.514061E-07 17 2.841E+01 5.241E+01 1.500E+01 5.280E-01 1.016E-04 1.016E-04 1.015E-04 5.2017E-08 5.201921E-08 18 3.314E+01 5.714E+01 1.750E+01 5.280E-01 8.705E-05 8.705E-05 8.701E-05 3.1781E-09 3.178270E-09 19 3.788E+01 6.188E+01 2.000E+01 5.280E-01 7.617E-05 7.617E-05 7.613E-05 1.9418E-10 1.941859E-10 20 4.735E+01 7.135E+01 2.500E+01 5.280E-01 6.094E-05 6.094E-05 6.091E-05 7.2484E-13 7.248894E-13 21 5.682E+01 8.082E+01 3.000E+01 5.280E-01 5.078E-05 5.078E-05 5.076E-05 2.7058E-15 2.705987E-15 22 6.629E+01 9.029E+01 3.500E+01 5.280E-01 4.353E-05 4.353E-05 4.351E-05 1.0100E-17 1.010136E-17 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.488E-03 2.400E+01 1.000E-01 6.720E+01 7.293E-01 7.293E-01 7.165E-01 8.7261E-01 8.729945E-01 25 3.720E-03 2.400E+01 2.500E-01 6.720E+01 4.976E-01 4.976E-01 4.810E-01 6.8063E-01 6.830526E-01 26 7.440E-03 2.401E+01 5.000E-01 6.720E+01 3.130E-01 3.130E-01 2.989E-01 4.3847E-01 4.438030E-01 27 1.488E-02 2.401E+01 1.000E+00 6.720E+01 1.751E-01 1.751E-01 1.660E-01 1.8040E-01 1.861019E-01 28 2.232E-02 2.402E+01 1.500E+00 6.720E+01 1.209E-01 1.209E-01 1.144E-01 7.4197E-02 7.802032E-02 29 2.976E-02 2.403E+01 2.000E+00 6.720E+01 9.225E-02 9.225E-02 8.718E-02 3.0516E-02 3.270876E-02 30 4.464E-02 2.404E+01 3.000E+00 6.720E+01 6.254E-02 6.254E-02 5.905E-02 5.1619E-03 5.748795E-03 31 5.952E-02 2.406E+01 4.000E+00 6.720E+01 4.730E-02 4.730E-02 4.464E-02 8.7316E-04 1.010391E-03 32 7.440E-02 2.407E+01 5.000E+00 6.720E+01 3.803E-02 3.803E-02 3.588E-02 1.4770E-04 1.775834E-04 33 8.929E-02 2.409E+01 6.000E+00 6.720E+01 3.179E-02 3.179E-02 2.999E-02 2.4984E-05 3.121153E-05 34 1.042E-01 2.410E+01 7.000E+00 6.720E+01 2.732E-02 2.732E-02 2.576E-02 4.2262E-06 5.485647E-06 35 1.190E-01 2.412E+01 8.000E+00 6.720E+01 2.394E-02 2.394E-02 2.258E-02 7.1487E-07 9.641411E-07 36 1.339E-01 2.413E+01 9.000E+00 6.720E+01 2.131E-02 2.131E-02 2.010E-02 1.2092E-07 1.694546E-07 37 1.488E-01 2.415E+01 1.000E+01 6.720E+01 1.920E-02 1.920E-02 1.810E-02 2.0455E-08 2.978284E-08 38 1.860E-01 2.419E+01 1.250E+01 6.720E+01 1.539E-02 1.539E-02 1.451E-02 2.4072E-10 3.856985E-10 39 2.232E-01 2.422E+01 1.500E+01 6.720E+01 1.284E-02 1.284E-02 1.211E-02 2.8328E-12 4.994935E-12 40 2.604E-01 2.426E+01 1.750E+01 6.720E+01 1.102E-02 1.102E-02 1.039E-02 3.3337E-14 6.468621E-14 41 2.976E-01 2.430E+01 2.000E+01 6.720E+01 9.648E-03 9.648E-03 9.094E-03 3.9231E-16 8.377098E-16 42 3.720E-01 2.437E+01 2.500E+01 6.720E+01 7.726E-03 7.726E-03 7.282E-03 5.4332E-20 1.404939E-19 43 4.464E-01 2.445E+01 3.000E+01 6.720E+01 6.442E-03 6.442E-03 6.072E-03 7.5244E-24 2.356249E-23 44 5.208E-01 2.452E+01 3.500E+01 6.720E+01 5.525E-03 5.525E-03 5.207E-03 1.0421E-27 3.951708E-27 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=12.0000 h, Tpot=42.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 1.008E+00 1.000E-01 8.9422E-01 8.9422E-01 8.9422E-01 4.0893E-01 4.0893E-01 4.0893E-01 4.0893E-01 3 1.020E+00 2.500E-01 7.5614E-01 7.5614E-01 7.5614E-01 4.6947E-01 4.6947E-01 4.6947E-01 4.6947E-01 4 1.039E+00 5.000E-01 5.7175E-01 5.7175E-01 5.7175E-01 5.6454E-01 5.6454E-01 5.6454E-01 5.6454E-01 5 1.079E+00 1.000E+00 3.2690E-01 3.2690E-01 3.2690E-01 7.2116E-01 7.2116E-01 7.2116E-01 7.2116E-01 6 1.118E+00 1.500E+00 1.8690E-01 1.8690E-01 1.8690E-01 8.2952E-01 8.2952E-01 8.2952E-01 8.2952E-01 7 1.158E+00 2.000E+00 1.0686E-01 1.0686E-01 1.0686E-01 8.9865E-01 8.9865E-01 8.9865E-01 8.9865E-01 8 1.237E+00 3.000E+00 3.4933E-02 3.4933E-02 3.4933E-02 9.6567E-01 9.6567E-01 9.6567E-01 9.6567E-01 9 1.316E+00 4.000E+00 1.1419E-02 1.1419E-02 1.1419E-02 9.8865E-01 9.8865E-01 9.8865E-01 9.8865E-01 10 1.395E+00 5.000E+00 3.7330E-03 3.7330E-03 3.7330E-03 9.9627E-01 9.9627E-01 9.9627E-01 9.9627E-01 11 1.473E+00 6.000E+00 1.2203E-03 1.2203E-03 1.2203E-03 9.9878E-01 9.9878E-01 9.9878E-01 9.9878E-01 12 1.552E+00 7.000E+00 3.9891E-04 3.9891E-04 3.9891E-04 9.9960E-01 9.9960E-01 9.9960E-01 9.9960E-01 13 1.631E+00 8.000E+00 1.3040E-04 1.3040E-04 1.3040E-04 9.9987E-01 9.9987E-01 9.9987E-01 9.9987E-01 14 1.710E+00 9.000E+00 4.2628E-05 4.2628E-05 4.2628E-05 9.9996E-01 9.9996E-01 9.9996E-01 9.9996E-01 15 1.789E+00 1.000E+01 1.3935E-05 1.3935E-05 1.3935E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 16 1.986E+00 1.250E+01 8.5141E-07 8.5141E-07 8.5141E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 17 2.184E+00 1.500E+01 5.2019E-08 5.2019E-08 5.2019E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 18 2.381E+00 1.750E+01 3.1783E-09 3.1783E-09 3.1783E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 19 2.578E+00 2.000E+01 1.9419E-10 1.9419E-10 1.9419E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 20 2.973E+00 2.500E+01 7.2489E-13 7.2489E-13 7.2489E-13 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 3.367E+00 3.000E+01 2.7060E-15 2.7060E-15 2.7060E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 3.762E+00 3.500E+01 1.0101E-17 1.0101E-17 1.0101E-17 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 1.000E+00 1.000E-01 8.7299E-01 8.7299E-01 8.7299E-01 4.1770E-01 4.1770E-01 4.1770E-01 4.1770E-01 25 1.000E+00 2.500E-01 6.8305E-01 6.8305E-01 6.8305E-01 5.0507E-01 5.0507E-01 5.0507E-01 5.0507E-01 26 1.000E+00 5.000E-01 4.4380E-01 4.4380E-01 4.4380E-01 6.4159E-01 6.4159E-01 6.4159E-01 6.4159E-01 27 1.001E+00 1.000E+00 1.8610E-01 1.8610E-01 1.8610E-01 8.3019E-01 8.3019E-01 8.3019E-01 8.3019E-01 28 1.001E+00 1.500E+00 7.8020E-02 7.8020E-02 7.8020E-02 9.2495E-01 9.2495E-01 9.2495E-01 9.2495E-01 29 1.001E+00 2.000E+00 3.2709E-02 3.2709E-02 3.2709E-02 9.6782E-01 9.6782E-01 9.6782E-01 9.6782E-01 30 1.002E+00 3.000E+00 5.7488E-03 5.7488E-03 5.7488E-03 9.9427E-01 9.9427E-01 9.9427E-01 9.9427E-01 31 1.002E+00 4.000E+00 1.0104E-03 1.0104E-03 1.0104E-03 9.9899E-01 9.9899E-01 9.9899E-01 9.9899E-01 32 1.003E+00 5.000E+00 1.7758E-04 1.7758E-04 1.7758E-04 9.9982E-01 9.9982E-01 9.9982E-01 9.9982E-01 33 1.004E+00 6.000E+00 3.1212E-05 3.1212E-05 3.1212E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 34 1.004E+00 7.000E+00 5.4856E-06 5.4856E-06 5.4856E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 35 1.005E+00 8.000E+00 9.6414E-07 9.6414E-07 9.6414E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 36 1.006E+00 9.000E+00 1.6945E-07 1.6945E-07 1.6945E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 37 1.006E+00 1.000E+01 2.9783E-08 2.9783E-08 2.9783E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 38 1.008E+00 1.250E+01 3.8570E-10 3.8570E-10 3.8570E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 39 1.009E+00 1.500E+01 4.9949E-12 4.9949E-12 4.9949E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 40 1.011E+00 1.750E+01 6.4686E-14 6.4686E-14 6.4686E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 1.012E+00 2.000E+01 8.3771E-16 8.3771E-16 8.3771E-16 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 1.016E+00 2.500E+01 1.4049E-19 1.4049E-19 1.4049E-19 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 1.019E+00 3.000E+01 2.3562E-23 2.3562E-23 2.3562E-23 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 1.022E+00 3.500E+01 3.9517E-27 3.9517E-27 3.9517E-27 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 1.894E-01 7.891E-03 0.0000E+00 1.0000E-01 0.0000E+00 5.2800E-01 3 4.735E-01 1.973E-02 0.0000E+00 2.5000E-01 0.0000E+00 5.2800E-01 4 9.470E-01 3.946E-02 0.0000E+00 5.0000E-01 0.0000E+00 5.2800E-01 5 1.894E+00 7.891E-02 0.0000E+00 1.0000E+00 0.0000E+00 5.2800E-01 6 2.841E+00 1.184E-01 0.0000E+00 1.5000E+00 0.0000E+00 5.2800E-01 7 3.788E+00 1.578E-01 0.0000E+00 2.0000E+00 0.0000E+00 5.2800E-01 8 5.682E+00 2.367E-01 0.0000E+00 3.0000E+00 0.0000E+00 5.2800E-01 9 7.576E+00 3.157E-01 0.0000E+00 4.0000E+00 0.0000E+00 5.2800E-01 10 9.470E+00 3.946E-01 0.0000E+00 5.0000E+00 0.0000E+00 5.2800E-01 11 1.136E+01 4.735E-01 0.0000E+00 6.0000E+00 0.0000E+00 5.2800E-01 12 1.326E+01 5.524E-01 0.0000E+00 7.0000E+00 0.0000E+00 5.2800E-01 13 1.515E+01 6.313E-01 0.0000E+00 8.0000E+00 0.0000E+00 5.2800E-01 14 1.705E+01 7.102E-01 0.0000E+00 9.0000E+00 0.0000E+00 5.2800E-01 15 1.894E+01 7.891E-01 0.0000E+00 1.0000E+01 0.0000E+00 5.2800E-01 16 2.367E+01 9.864E-01 0.0000E+00 1.2500E+01 0.0000E+00 5.2800E-01 17 2.841E+01 1.184E+00 0.0000E+00 1.5000E+01 0.0000E+00 5.2800E-01 18 3.314E+01 1.381E+00 0.0000E+00 1.7500E+01 0.0000E+00 5.2800E-01 19 3.788E+01 1.578E+00 0.0000E+00 2.0000E+01 0.0000E+00 5.2800E-01 20 4.735E+01 1.973E+00 0.0000E+00 2.5000E+01 0.0000E+00 5.2800E-01 21 5.682E+01 2.367E+00 0.0000E+00 3.0000E+01 0.0000E+00 5.2800E-01 22 6.629E+01 2.762E+00 0.0000E+00 3.5000E+01 0.0000E+00 5.2800E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.488E-03 6.200E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.7200E+01 25 3.720E-03 1.550E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.7200E+01 26 7.440E-03 3.100E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.7200E+01 27 1.488E-02 6.200E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.7200E+01 28 2.232E-02 9.301E-04 0.0000E+00 1.5000E+00 0.0000E+00 6.7200E+01 29 2.976E-02 1.240E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.7200E+01 30 4.464E-02 1.860E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.7200E+01 31 5.952E-02 2.480E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.7200E+01 32 7.440E-02 3.100E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.7200E+01 33 8.929E-02 3.720E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.7200E+01 34 1.042E-01 4.340E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.7200E+01 35 1.190E-01 4.960E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.7200E+01 36 1.339E-01 5.580E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.7200E+01 37 1.488E-01 6.200E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.7200E+01 38 1.860E-01 7.750E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.7200E+01 39 2.232E-01 9.301E-03 0.0000E+00 1.5000E+01 0.0000E+00 6.7200E+01 40 2.604E-01 1.085E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.7200E+01 41 2.976E-01 1.240E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.7200E+01 42 3.720E-01 1.550E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.7200E+01 43 4.464E-01 1.860E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.7200E+01 44 5.208E-01 2.170E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.7200E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 6.50000E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 07:32:30 PM