VC 2.00I 15-JUL-2003 02-AUG-2003 07:17:55 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\ht144\rmr\ht144.inp FNI: U:\archive\ht144\rmr\ht144.inp FNO: U:\archive\ht144\rmr\ht144.out RADX: U:\archive\ht144\rmr\ht144.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- RMRM TABLE: Summary of RMR parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 2.58403E-11 1.58814E-02 90.000000 DAMAGE REPAIR/MISREPAIR: A0= 0.000000E+00 (=0.000%) (1-A0)*PHI= 1.236750E-02 (=1.237%) (1-A0)*(1-PHI)= 9.876325E-01 (=98.763%) RHT= 0.002283 h (=0.14 minute) LAM= 3.0361377E+02 (1/h) BMR= 4.8929477E-01 (1/h) LAM/BMR= 6.2051302E+02 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 1.113075 (1/Gy) beta = 1.550993 (1/Gy^2) alpha/beta = 0.717653 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 1.894E-01 2.419E+01 1.000E-01 5.280E-01 1.118E-01 0.000E+00 1.1184E-01 8.941897E-01 3 4.735E-01 2.447E+01 2.500E-01 5.280E-01 2.796E-01 0.000E+00 2.7961E-01 7.560806E-01 4 9.470E-01 2.495E+01 5.000E-01 5.280E-01 5.592E-01 0.000E+00 5.5922E-01 5.716525E-01 5 1.894E+00 2.589E+01 1.000E+00 5.280E-01 1.118E+00 0.000E+00 1.1185E+00 3.267835E-01 6 2.841E+00 2.684E+01 1.500E+00 5.280E-01 1.678E+00 0.000E+00 1.6777E+00 1.868048E-01 7 3.788E+00 2.779E+01 2.000E+00 5.280E-01 2.237E+00 0.000E+00 2.2369E+00 1.067864E-01 8 5.682E+00 2.968E+01 3.000E+00 5.280E-01 3.355E+00 0.000E+00 3.3554E+00 3.489571E-02 9 7.576E+00 3.158E+01 4.000E+00 5.280E-01 4.474E+00 0.000E+00 4.4739E+00 1.140324E-02 10 9.470E+00 3.347E+01 5.000E+00 5.280E-01 5.592E+00 0.000E+00 5.5923E+00 3.726354E-03 11 1.136E+01 3.536E+01 6.000E+00 5.280E-01 6.711E+00 0.000E+00 6.7108E+00 1.217699E-03 12 1.326E+01 3.726E+01 7.000E+00 5.280E-01 7.829E+00 0.000E+00 7.8293E+00 3.979203E-04 13 1.515E+01 3.915E+01 8.000E+00 5.280E-01 8.948E+00 0.000E+00 8.9477E+00 1.300326E-04 14 1.705E+01 4.105E+01 9.000E+00 5.280E-01 1.007E+01 0.000E+00 1.0066E+01 4.249209E-05 15 1.894E+01 4.294E+01 1.000E+01 5.280E-01 1.118E+01 0.000E+00 1.1185E+01 1.388558E-05 16 2.367E+01 4.767E+01 1.250E+01 5.280E-01 1.398E+01 0.000E+00 1.3981E+01 8.476257E-07 17 2.841E+01 5.241E+01 1.500E+01 5.280E-01 1.678E+01 0.000E+00 1.6777E+01 5.174211E-08 18 3.314E+01 5.714E+01 1.750E+01 5.280E-01 1.957E+01 0.000E+00 1.9573E+01 3.158524E-09 19 3.788E+01 6.188E+01 2.000E+01 5.280E-01 2.237E+01 0.000E+00 2.2369E+01 1.928076E-10 20 4.735E+01 7.135E+01 2.500E+01 5.280E-01 2.796E+01 0.000E+00 2.7962E+01 7.184626E-13 21 5.682E+01 8.082E+01 3.000E+01 5.280E-01 3.355E+01 0.000E+00 3.3554E+01 2.677221E-15 22 6.629E+01 9.029E+01 3.500E+01 5.280E-01 3.915E+01 0.000E+00 3.9146E+01 9.976178E-18 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.488E-03 2.400E+01 1.000E-01 6.720E+01 1.246E-01 0.000E+00 1.2460E-01 8.828462E-01 25 3.720E-03 2.400E+01 2.500E-01 6.720E+01 3.457E-01 0.000E+00 3.4572E-01 7.077119E-01 26 7.440E-03 2.401E+01 5.000E-01 6.720E+01 7.571E-01 0.000E+00 7.5712E-01 4.690145E-01 27 1.488E-02 2.401E+01 1.000E+00 6.720E+01 1.625E+00 0.000E+00 1.6254E+00 1.968255E-01 28 2.232E-02 2.402E+01 1.500E+00 6.720E+01 2.504E+00 3.880E-30 2.5038E+00 8.177048E-02 29 2.976E-02 2.403E+01 2.000E+00 6.720E+01 3.383E+00 4.303E-30 3.3832E+00 3.394019E-02 30 4.464E-02 2.404E+01 3.000E+00 6.720E+01 5.142E+00 4.118E-30 5.1420E+00 5.846206E-03 31 5.952E-02 2.406E+01 4.000E+00 6.720E+01 6.901E+00 3.588E-30 6.9008E+00 1.007002E-03 32 7.440E-02 2.407E+01 5.000E+00 6.720E+01 8.660E+00 4.243E-30 8.6596E+00 1.734547E-04 33 8.929E-02 2.409E+01 6.000E+00 6.720E+01 1.042E+01 4.165E-30 1.0418E+01 2.987736E-05 34 1.042E-01 2.410E+01 7.000E+00 6.720E+01 1.218E+01 4.370E-30 1.2177E+01 5.146337E-06 35 1.190E-01 2.412E+01 8.000E+00 6.720E+01 1.394E+01 3.893E-30 1.3936E+01 8.864499E-07 36 1.339E-01 2.413E+01 9.000E+00 6.720E+01 1.569E+01 3.894E-30 1.5695E+01 1.526899E-07 37 1.488E-01 2.415E+01 1.000E+01 6.720E+01 1.745E+01 3.953E-30 1.7454E+01 2.630063E-08 38 1.860E-01 2.419E+01 1.250E+01 6.720E+01 2.185E+01 4.300E-30 2.1851E+01 3.238592E-10 39 2.232E-01 2.422E+01 1.500E+01 6.720E+01 2.625E+01 4.119E-30 2.6248E+01 3.987918E-12 40 2.604E-01 2.426E+01 1.750E+01 6.720E+01 3.064E+01 3.625E-30 3.0645E+01 4.910619E-14 41 2.976E-01 2.430E+01 2.000E+01 6.720E+01 3.504E+01 4.329E-30 3.5042E+01 6.046809E-16 42 3.720E-01 2.437E+01 2.500E+01 6.720E+01 4.384E+01 4.099E-30 4.3836E+01 9.168668E-20 43 4.464E-01 2.445E+01 3.000E+01 6.720E+01 5.263E+01 4.283E-30 5.2630E+01 1.390229E-23 44 5.208E-01 2.452E+01 3.500E+01 6.720E+01 6.142E+01 3.903E-30 6.1424E+01 2.107979E-27 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 1.008E+00 1.000E-01 5.280E-01 8.9419E-01 8.9419E-01 1.0000E+00 8.9419E-01 8.9419E-01 8.9419E-01 3 1.020E+00 2.500E-01 5.280E-01 7.5608E-01 7.5608E-01 1.0000E+00 7.5608E-01 7.5608E-01 7.5608E-01 4 1.039E+00 5.000E-01 5.280E-01 5.7165E-01 5.7165E-01 1.0000E+00 5.7165E-01 5.7165E-01 5.7165E-01 5 1.079E+00 1.000E+00 5.280E-01 3.2678E-01 3.2678E-01 1.0000E+00 3.2678E-01 3.2678E-01 3.2678E-01 6 1.118E+00 1.500E+00 5.280E-01 1.8680E-01 1.8680E-01 1.0000E+00 1.8680E-01 1.8680E-01 1.8680E-01 7 1.158E+00 2.000E+00 5.280E-01 1.0679E-01 1.0679E-01 1.0000E+00 1.0679E-01 1.0679E-01 1.0679E-01 8 1.237E+00 3.000E+00 5.280E-01 3.4896E-02 3.4896E-02 1.0000E+00 3.4896E-02 3.4896E-02 3.4896E-02 9 1.316E+00 4.000E+00 5.280E-01 1.1403E-02 1.1403E-02 1.0000E+00 1.1403E-02 1.1403E-02 1.1403E-02 10 1.395E+00 5.000E+00 5.280E-01 3.7264E-03 3.7264E-03 1.0000E+00 3.7264E-03 3.7264E-03 3.7264E-03 11 1.473E+00 6.000E+00 5.280E-01 1.2177E-03 1.2177E-03 1.0000E+00 1.2177E-03 1.2177E-03 1.2177E-03 12 1.552E+00 7.000E+00 5.280E-01 3.9792E-04 3.9792E-04 1.0000E+00 3.9792E-04 3.9792E-04 3.9792E-04 13 1.631E+00 8.000E+00 5.280E-01 1.3003E-04 1.3003E-04 1.0000E+00 1.3003E-04 1.3003E-04 1.3003E-04 14 1.710E+00 9.000E+00 5.280E-01 4.2492E-05 4.2492E-05 1.0000E+00 4.2492E-05 4.2492E-05 4.2492E-05 15 1.789E+00 1.000E+01 5.280E-01 1.3886E-05 1.3886E-05 1.0000E+00 1.3886E-05 1.3886E-05 1.3886E-05 16 1.986E+00 1.250E+01 5.280E-01 8.4763E-07 8.4763E-07 1.0000E+00 8.4763E-07 8.4763E-07 8.4763E-07 17 2.184E+00 1.500E+01 5.280E-01 5.1742E-08 5.1742E-08 1.0000E+00 5.1742E-08 5.1742E-08 5.1742E-08 18 2.381E+00 1.750E+01 5.280E-01 3.1585E-09 3.1585E-09 1.0000E+00 3.1585E-09 3.1585E-09 3.1585E-09 19 2.578E+00 2.000E+01 5.280E-01 1.9281E-10 1.9281E-10 1.0000E+00 1.9281E-10 1.9281E-10 1.9281E-10 20 2.973E+00 2.500E+01 5.280E-01 7.1846E-13 7.1846E-13 1.0000E+00 7.1846E-13 7.1846E-13 7.1846E-13 21 3.367E+00 3.000E+01 5.280E-01 2.6772E-15 2.6772E-15 1.0000E+00 2.6772E-15 2.6772E-15 2.6772E-15 22 3.762E+00 3.500E+01 5.280E-01 9.9762E-18 9.9762E-18 1.0000E+00 9.9762E-18 9.9762E-18 9.9762E-18 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 1.000E+00 1.000E-01 6.720E+01 8.8285E-01 8.8285E-01 1.0000E+00 8.8285E-01 8.8285E-01 8.8285E-01 25 1.000E+00 2.500E-01 6.720E+01 7.0771E-01 7.0771E-01 1.0000E+00 7.0771E-01 7.0771E-01 7.0771E-01 26 1.000E+00 5.000E-01 6.720E+01 4.6901E-01 4.6901E-01 1.0000E+00 4.6901E-01 4.6901E-01 4.6901E-01 27 1.001E+00 1.000E+00 6.720E+01 1.9683E-01 1.9683E-01 1.0000E+00 1.9683E-01 1.9683E-01 1.9683E-01 28 1.001E+00 1.500E+00 6.720E+01 8.1770E-02 8.1770E-02 1.0000E+00 8.1770E-02 8.1770E-02 8.1770E-02 29 1.001E+00 2.000E+00 6.720E+01 3.3940E-02 3.3940E-02 1.0000E+00 3.3940E-02 3.3940E-02 3.3940E-02 30 1.002E+00 3.000E+00 6.720E+01 5.8462E-03 5.8462E-03 1.0000E+00 5.8462E-03 5.8462E-03 5.8462E-03 31 1.002E+00 4.000E+00 6.720E+01 1.0070E-03 1.0070E-03 1.0000E+00 1.0070E-03 1.0070E-03 1.0070E-03 32 1.003E+00 5.000E+00 6.720E+01 1.7345E-04 1.7345E-04 1.0000E+00 1.7345E-04 1.7345E-04 1.7345E-04 33 1.004E+00 6.000E+00 6.720E+01 2.9877E-05 2.9877E-05 1.0000E+00 2.9877E-05 2.9877E-05 2.9877E-05 34 1.004E+00 7.000E+00 6.720E+01 5.1463E-06 5.1463E-06 1.0000E+00 5.1463E-06 5.1463E-06 5.1463E-06 35 1.005E+00 8.000E+00 6.720E+01 8.8645E-07 8.8645E-07 1.0000E+00 8.8645E-07 8.8645E-07 8.8645E-07 36 1.006E+00 9.000E+00 6.720E+01 1.5269E-07 1.5269E-07 1.0000E+00 1.5269E-07 1.5269E-07 1.5269E-07 37 1.006E+00 1.000E+01 6.720E+01 2.6301E-08 2.6301E-08 1.0000E+00 2.6301E-08 2.6301E-08 2.6301E-08 38 1.008E+00 1.250E+01 6.720E+01 3.2386E-10 3.2386E-10 1.0000E+00 3.2386E-10 3.2386E-10 3.2386E-10 39 1.009E+00 1.500E+01 6.720E+01 3.9879E-12 3.9879E-12 1.0000E+00 3.9879E-12 3.9879E-12 3.9879E-12 40 1.011E+00 1.750E+01 6.720E+01 4.9106E-14 4.9106E-14 1.0000E+00 4.9106E-14 4.9106E-14 4.9106E-14 41 1.012E+00 2.000E+01 6.720E+01 6.0468E-16 6.0468E-16 1.0000E+00 6.0468E-16 6.0468E-16 6.0468E-16 42 1.016E+00 2.500E+01 6.720E+01 9.1687E-20 9.1687E-20 1.0000E+00 9.1687E-20 9.1687E-20 9.1687E-20 43 1.019E+00 3.000E+01 6.720E+01 1.3902E-23 1.3902E-23 1.0000E+00 1.3902E-23 1.3902E-23 1.3902E-23 44 1.022E+00 3.500E+01 6.720E+01 2.1080E-27 2.1080E-27 1.0000E+00 2.1080E-27 2.1080E-27 2.1080E-27 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 5.280E-01 8.888E+00 0.00E+00 8.88816E+00 3.378E-05 3.378E-05 3.777E-05 3 2.500E-01 5.280E-01 2.222E+01 0.00E+00 2.22204E+01 7.140E-05 7.140E-05 9.443E-05 4 5.000E-01 5.280E-01 4.444E+01 0.00E+00 4.44408E+01 1.080E-04 1.080E-04 1.889E-04 5 1.000E+00 5.280E-01 8.888E+01 0.00E+00 8.88815E+01 1.234E-04 1.234E-04 3.777E-04 6 1.500E+00 5.280E-01 1.333E+02 0.00E+00 1.33322E+02 1.058E-04 1.058E-04 5.665E-04 7 2.000E+00 5.280E-01 1.778E+02 0.00E+00 1.77763E+02 8.065E-05 8.065E-05 7.552E-04 8 3.000E+00 5.280E-01 2.666E+02 0.00E+00 2.66645E+02 3.952E-05 3.952E-05 1.133E-03 9 4.000E+00 5.280E-01 3.555E+02 0.00E+00 3.55526E+02 1.722E-05 1.722E-05 1.510E-03 10 5.000E+00 5.280E-01 4.444E+02 0.00E+00 4.44408E+02 7.031E-06 7.031E-06 1.887E-03 11 6.000E+00 5.280E-01 5.333E+02 0.00E+00 5.33289E+02 2.757E-06 2.757E-06 2.264E-03 12 7.000E+00 5.280E-01 6.222E+02 0.00E+00 6.22171E+02 1.051E-06 1.051E-06 2.641E-03 13 8.000E+00 5.280E-01 7.111E+02 0.00E+00 7.11052E+02 3.924E-07 3.924E-07 3.017E-03 14 9.000E+00 5.280E-01 7.999E+02 0.00E+00 7.99934E+02 1.442E-07 1.442E-07 3.394E-03 15 1.000E+01 5.280E-01 8.888E+02 0.00E+00 8.88815E+02 5.235E-08 5.235E-08 3.770E-03 16 1.250E+01 5.280E-01 1.111E+03 0.00E+00 1.11102E+03 3.993E-09 3.993E-09 4.711E-03 17 1.500E+01 5.280E-01 1.333E+03 0.00E+00 1.33322E+03 2.924E-10 2.924E-10 5.650E-03 18 1.750E+01 5.280E-01 1.555E+03 0.00E+00 1.55543E+03 2.081E-11 2.081E-11 6.589E-03 19 2.000E+01 5.280E-01 1.778E+03 0.00E+00 1.77763E+03 1.451E-12 1.451E-12 7.526E-03 20 2.500E+01 5.280E-01 2.222E+03 0.00E+00 2.22204E+03 6.753E-15 6.753E-15 9.399E-03 21 3.000E+01 5.280E-01 2.666E+03 0.00E+00 2.66645E+03 3.017E-17 3.017E-17 1.127E-02 22 3.500E+01 5.280E-01 3.111E+03 0.00E+00 3.11085E+03 1.310E-19 1.310E-19 1.313E-02 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.720E+01 8.875E+00 0.00E+00 8.87540E+00 3.330E-05 3.330E-05 3.772E-05 25 2.500E-01 6.720E+01 2.215E+01 0.00E+00 2.21543E+01 6.663E-05 6.663E-05 9.415E-05 26 5.000E-01 6.720E+01 4.424E+01 0.00E+00 4.42429E+01 8.818E-05 8.818E-05 1.880E-04 27 1.000E+00 6.720E+01 8.837E+01 0.00E+00 8.83746E+01 7.391E-05 7.391E-05 3.755E-04 28 1.500E+00 6.720E+01 1.325E+02 0.00E+00 1.32496E+02 4.603E-05 4.603E-05 5.630E-04 29 2.000E+00 6.720E+01 1.766E+02 0.00E+00 1.76617E+02 2.547E-05 2.547E-05 7.503E-04 30 3.000E+00 6.720E+01 2.649E+02 0.00E+00 2.64858E+02 6.577E-06 6.577E-06 1.125E-03 31 4.000E+00 6.720E+01 3.531E+02 0.00E+00 3.53099E+02 1.510E-06 1.510E-06 1.500E-03 32 5.000E+00 6.720E+01 4.413E+02 0.00E+00 4.41340E+02 3.250E-07 3.250E-07 1.874E-03 33 6.000E+00 6.720E+01 5.296E+02 0.00E+00 5.29582E+02 6.717E-08 6.717E-08 2.248E-03 34 7.000E+00 6.720E+01 6.178E+02 0.00E+00 6.17823E+02 1.350E-08 1.350E-08 2.622E-03 35 8.000E+00 6.720E+01 7.061E+02 0.00E+00 7.06064E+02 2.656E-09 2.656E-09 2.996E-03 36 9.000E+00 6.720E+01 7.943E+02 0.00E+00 7.94305E+02 5.146E-10 5.146E-10 3.370E-03 37 1.000E+01 6.720E+01 8.825E+02 0.00E+00 8.82546E+02 9.846E-11 9.846E-11 3.744E-03 38 1.250E+01 6.720E+01 1.103E+03 0.00E+00 1.10315E+03 1.515E-12 1.515E-12 4.677E-03 39 1.500E+01 6.720E+01 1.324E+03 0.00E+00 1.32375E+03 2.237E-14 2.237E-14 5.610E-03 40 1.750E+01 6.720E+01 1.544E+03 0.00E+00 1.54436E+03 3.213E-16 3.213E-16 6.542E-03 41 2.000E+01 6.720E+01 1.765E+03 0.00E+00 1.76496E+03 4.519E-18 4.519E-18 7.473E-03 42 2.500E+01 6.720E+01 2.206E+03 0.00E+00 2.20616E+03 8.557E-22 8.557E-22 9.332E-03 43 3.000E+01 6.720E+01 2.647E+03 0.00E+00 2.64737E+03 1.555E-25 1.555E-25 1.119E-02 44 3.500E+01 6.720E+01 3.089E+03 0.00E+00 3.08858E+03 2.749E-29 2.749E-29 1.304E-02 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 5.280E-01 8.888E+00 3.378E-05 3.777E-05 6.8993E-05 6.9443E-05 6.2095E-05 3 2.500E-01 5.280E-01 2.222E+01 7.140E-05 9.443E-05 6.8989E-05 7.0115E-05 5.3013E-05 4 5.000E-01 5.280E-01 4.444E+01 1.080E-04 1.889E-04 6.8982E-05 7.1235E-05 4.0722E-05 5 1.000E+00 5.280E-01 8.888E+01 1.234E-04 3.777E-04 6.8969E-05 7.3474E-05 2.4010E-05 6 1.500E+00 5.280E-01 1.333E+02 1.058E-04 5.665E-04 6.8956E-05 7.5713E-05 1.4144E-05 7 2.000E+00 5.280E-01 1.778E+02 8.065E-05 7.552E-04 6.8943E-05 7.7951E-05 8.3242E-06 8 3.000E+00 5.280E-01 2.666E+02 3.952E-05 1.133E-03 6.8917E-05 8.2427E-05 2.8763E-06 9 4.000E+00 5.280E-01 3.555E+02 1.722E-05 1.510E-03 6.8891E-05 8.6901E-05 9.9095E-07 10 5.000E+00 5.280E-01 4.444E+02 7.031E-06 1.887E-03 6.8865E-05 9.1373E-05 3.4049E-07 11 6.000E+00 5.280E-01 5.333E+02 2.757E-06 2.264E-03 6.8839E-05 9.5844E-05 1.1671E-07 12 7.000E+00 5.280E-01 6.222E+02 1.051E-06 2.641E-03 6.8813E-05 1.0031E-04 3.9916E-08 13 8.000E+00 5.280E-01 7.111E+02 3.924E-07 3.017E-03 6.8787E-05 1.0478E-04 1.3625E-08 14 9.000E+00 5.280E-01 7.999E+02 1.442E-07 3.394E-03 6.8761E-05 1.0925E-04 4.6420E-09 15 1.000E+01 5.280E-01 8.888E+02 5.235E-08 3.770E-03 6.8735E-05 1.1371E-04 1.5789E-09 16 1.250E+01 5.280E-01 1.111E+03 3.993E-09 4.711E-03 6.8670E-05 1.2486E-04 1.0584E-10 17 1.500E+01 5.280E-01 1.333E+03 2.924E-10 5.650E-03 6.8605E-05 1.3600E-04 7.0370E-12 18 1.750E+01 5.280E-01 1.555E+03 2.081E-11 6.589E-03 6.8541E-05 1.4713E-04 4.6472E-13 19 2.000E+01 5.280E-01 1.778E+03 1.451E-12 7.526E-03 6.8476E-05 1.5825E-04 3.0513E-14 20 2.500E+01 5.280E-01 2.222E+03 6.753E-15 9.399E-03 6.8347E-05 1.8046E-04 1.2966E-16 21 3.000E+01 5.280E-01 2.666E+03 3.017E-17 1.127E-02 6.8218E-05 2.0263E-04 5.4249E-19 22 3.500E+01 5.280E-01 3.111E+03 1.310E-19 1.313E-02 6.8089E-05 2.2476E-04 2.2422E-21 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.720E+01 8.875E+00 3.330E-05 3.772E-05 6.8993E-05 6.9443E-05 6.1307E-05 25 2.500E-01 6.720E+01 2.215E+01 6.663E-05 9.415E-05 6.8989E-05 7.0112E-05 4.9619E-05 26 5.000E-01 6.720E+01 4.424E+01 8.818E-05 1.880E-04 6.8982E-05 7.1225E-05 3.3406E-05 27 1.000E+00 6.720E+01 8.837E+01 7.391E-05 3.755E-04 6.8969E-05 7.3449E-05 1.4457E-05 28 1.500E+00 6.720E+01 1.325E+02 4.603E-05 5.630E-04 6.8956E-05 7.5671E-05 6.1877E-06 29 2.000E+00 6.720E+01 1.766E+02 2.547E-05 7.503E-04 6.8943E-05 7.7894E-05 2.6437E-06 30 3.000E+00 6.720E+01 2.649E+02 6.577E-06 1.125E-03 6.8918E-05 8.2337E-05 4.8136E-07 31 4.000E+00 6.720E+01 3.531E+02 1.510E-06 1.500E-03 6.8892E-05 8.6779E-05 8.7386E-08 32 5.000E+00 6.720E+01 4.413E+02 3.250E-07 1.874E-03 6.8866E-05 9.1219E-05 1.5822E-08 33 6.000E+00 6.720E+01 5.296E+02 6.717E-08 2.248E-03 6.8840E-05 9.5657E-05 2.8580E-09 34 7.000E+00 6.720E+01 6.178E+02 1.350E-08 2.622E-03 6.8814E-05 1.0009E-04 5.1512E-10 35 8.000E+00 6.720E+01 7.061E+02 2.656E-09 2.996E-03 6.8788E-05 1.0453E-04 9.2660E-11 36 9.000E+00 6.720E+01 7.943E+02 5.146E-10 3.370E-03 6.8763E-05 1.0896E-04 1.6637E-11 37 1.000E+01 6.720E+01 8.825E+02 9.846E-11 3.744E-03 6.8737E-05 1.1339E-04 2.9823E-12 38 1.250E+01 6.720E+01 1.103E+03 1.515E-12 4.677E-03 6.8673E-05 1.2447E-04 4.0309E-14 39 1.500E+01 6.720E+01 1.324E+03 2.237E-14 5.610E-03 6.8608E-05 1.3553E-04 5.4047E-16 40 1.750E+01 6.720E+01 1.544E+03 3.213E-16 6.542E-03 6.8544E-05 1.4658E-04 7.1979E-18 41 2.000E+01 6.720E+01 1.765E+03 4.519E-18 7.473E-03 6.8480E-05 1.5762E-04 9.5310E-20 42 2.500E+01 6.720E+01 2.206E+03 8.557E-22 9.332E-03 6.8351E-05 1.7967E-04 1.6473E-23 43 3.000E+01 6.720E+01 2.647E+03 1.555E-25 1.119E-02 6.8223E-05 2.0168E-04 2.8038E-27 44 3.500E+01 6.720E+01 3.089E+03 2.749E-29 1.304E-02 6.8095E-05 2.2365E-04 4.7145E-31 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency RMRM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 1.113 (1/Gy), alpha/beta = 0.718 (Gy) , lamda = 3.036E+02 (1/h). ====================================================================================================== --- Duration (h) --- Dose Dose Rate* ***** G FACTOR ***** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL GEFF SF1 SF2 ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 1.894E-01 2.419E+01 1.000E-01 5.280E-01 3.418E-02 3.416E-02 8.9419E-01 8.941897E-01 3 4.735E-01 2.447E+01 2.500E-01 5.280E-01 1.382E-02 1.381E-02 7.5608E-01 7.560806E-01 4 9.470E-01 2.495E+01 5.000E-01 5.280E-01 6.932E-03 6.929E-03 5.7165E-01 5.716525E-01 5 1.894E+00 2.589E+01 1.000E+00 5.280E-01 3.472E-03 3.470E-03 3.2678E-01 3.267835E-01 6 2.841E+00 2.684E+01 1.500E+00 5.280E-01 2.316E-03 2.315E-03 1.8680E-01 1.868048E-01 7 3.788E+00 2.779E+01 2.000E+00 5.280E-01 1.738E-03 1.737E-03 1.0679E-01 1.067864E-01 8 5.682E+00 2.968E+01 3.000E+00 5.280E-01 1.159E-03 1.158E-03 3.4895E-02 3.489571E-02 9 7.576E+00 3.158E+01 4.000E+00 5.280E-01 8.691E-04 8.687E-04 1.1403E-02 1.140324E-02 10 9.470E+00 3.347E+01 5.000E+00 5.280E-01 6.954E-04 6.950E-04 3.7263E-03 3.726354E-03 11 1.136E+01 3.536E+01 6.000E+00 5.280E-01 5.795E-04 5.792E-04 1.2177E-03 1.217699E-03 12 1.326E+01 3.726E+01 7.000E+00 5.280E-01 4.967E-04 4.965E-04 3.9791E-04 3.979203E-04 13 1.515E+01 3.915E+01 8.000E+00 5.280E-01 4.347E-04 4.344E-04 1.3003E-04 1.300326E-04 14 1.705E+01 4.105E+01 9.000E+00 5.280E-01 3.864E-04 3.862E-04 4.2491E-05 4.249209E-05 15 1.894E+01 4.294E+01 1.000E+01 5.280E-01 3.477E-04 3.476E-04 1.3885E-05 1.388558E-05 16 2.367E+01 4.767E+01 1.250E+01 5.280E-01 2.782E-04 2.781E-04 8.4760E-07 8.476257E-07 17 2.841E+01 5.241E+01 1.500E+01 5.280E-01 2.318E-04 2.317E-04 5.1740E-08 5.174211E-08 18 3.314E+01 5.714E+01 1.750E+01 5.280E-01 1.987E-04 1.986E-04 3.1584E-09 3.158524E-09 19 3.788E+01 6.188E+01 2.000E+01 5.280E-01 1.739E-04 1.738E-04 1.9280E-10 1.928076E-10 20 4.735E+01 7.135E+01 2.500E+01 5.280E-01 1.391E-04 1.390E-04 7.1841E-13 7.184626E-13 21 5.682E+01 8.082E+01 3.000E+01 5.280E-01 1.159E-04 1.159E-04 2.6770E-15 2.677221E-15 22 6.629E+01 9.029E+01 3.500E+01 5.280E-01 9.937E-05 9.932E-05 9.9752E-18 9.976178E-18 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.488E-03 2.400E+01 1.000E-01 6.720E+01 8.650E-01 8.573E-01 8.8274E-01 8.828462E-01 25 3.720E-03 2.400E+01 2.500E-01 6.720E+01 7.097E-01 6.958E-01 7.0676E-01 7.077119E-01 26 7.440E-03 2.401E+01 5.000E-01 6.720E+01 5.344E-01 5.173E-01 4.6592E-01 4.690145E-01 27 1.488E-02 2.401E+01 1.000E+00 6.720E+01 3.458E-01 3.303E-01 1.9218E-01 1.968255E-01 28 2.232E-02 2.402E+01 1.500E+00 6.720E+01 2.516E-01 2.391E-01 7.8263E-02 8.177048E-02 29 2.976E-02 2.403E+01 2.000E+00 6.720E+01 1.968E-01 1.865E-01 3.1830E-02 3.394019E-02 30 4.464E-02 2.404E+01 3.000E+00 6.720E+01 1.367E-01 1.291E-01 5.2634E-03 5.846206E-03 31 5.952E-02 2.406E+01 4.000E+00 6.720E+01 1.045E-01 9.867E-02 8.7033E-04 1.007002E-03 32 7.440E-02 2.407E+01 5.000E+00 6.720E+01 8.461E-02 7.980E-02 1.4392E-04 1.734547E-04 33 8.929E-02 2.409E+01 6.000E+00 6.720E+01 7.106E-02 6.698E-02 2.3797E-05 2.987736E-05 34 1.042E-01 2.410E+01 7.000E+00 6.720E+01 6.124E-02 5.771E-02 3.9351E-06 5.146337E-06 35 1.190E-01 2.412E+01 8.000E+00 6.720E+01 5.380E-02 5.069E-02 6.5069E-07 8.864499E-07 36 1.339E-01 2.413E+01 9.000E+00 6.720E+01 4.798E-02 4.519E-02 1.0760E-07 1.526899E-07 37 1.488E-01 2.415E+01 1.000E+01 6.720E+01 4.329E-02 4.077E-02 1.7792E-08 2.630063E-08 38 1.860E-01 2.419E+01 1.250E+01 6.720E+01 3.479E-02 3.275E-02 1.9782E-10 3.238592E-10 39 2.232E-01 2.422E+01 1.500E+01 6.720E+01 2.908E-02 2.737E-02 2.1995E-12 3.987918E-12 40 2.604E-01 2.426E+01 1.750E+01 6.720E+01 2.498E-02 2.351E-02 2.4456E-14 4.910619E-14 41 2.976E-01 2.430E+01 2.000E+01 6.720E+01 2.189E-02 2.060E-02 2.7192E-16 6.046809E-16 42 3.720E-01 2.437E+01 2.500E+01 6.720E+01 1.755E-02 1.651E-02 3.3616E-20 9.168668E-20 43 4.464E-01 2.445E+01 3.000E+01 6.720E+01 1.465E-02 1.378E-02 4.1558E-24 1.390229E-23 44 5.208E-01 2.452E+01 3.500E+01 6.720E+01 1.257E-02 1.182E-02 5.1377E-28 2.107979E-27 ------------------------------------------------------------------------------------------------------ GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/D)/(beta*D). In the formula for GEFF, SF is surviving fraction as computed using the RMR model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL. The SF estimates are: SF1=EXP{-dose*[alpha+gl*beta*dose]} and SF2=EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 1.008E+00 1.000E-01 8.9419E-01 8.9419E-01 8.9419E-01 4.0894E-01 4.0894E-01 4.0894E-01 4.0894E-01 3 1.020E+00 2.500E-01 7.5608E-01 7.5608E-01 7.5608E-01 4.6950E-01 4.6950E-01 4.6950E-01 4.6950E-01 4 1.039E+00 5.000E-01 5.7165E-01 5.7165E-01 5.7165E-01 5.6459E-01 5.6459E-01 5.6459E-01 5.6459E-01 5 1.079E+00 1.000E+00 3.2678E-01 3.2678E-01 3.2678E-01 7.2124E-01 7.2124E-01 7.2124E-01 7.2124E-01 6 1.118E+00 1.500E+00 1.8680E-01 1.8680E-01 1.8680E-01 8.2961E-01 8.2961E-01 8.2961E-01 8.2961E-01 7 1.158E+00 2.000E+00 1.0679E-01 1.0679E-01 1.0679E-01 8.9872E-01 8.9872E-01 8.9872E-01 8.9872E-01 8 1.237E+00 3.000E+00 3.4896E-02 3.4896E-02 3.4896E-02 9.6571E-01 9.6571E-01 9.6571E-01 9.6571E-01 9 1.316E+00 4.000E+00 1.1403E-02 1.1403E-02 1.1403E-02 9.8866E-01 9.8866E-01 9.8866E-01 9.8866E-01 10 1.395E+00 5.000E+00 3.7264E-03 3.7264E-03 3.7264E-03 9.9628E-01 9.9628E-01 9.9628E-01 9.9628E-01 11 1.473E+00 6.000E+00 1.2177E-03 1.2177E-03 1.2177E-03 9.9878E-01 9.9878E-01 9.9878E-01 9.9878E-01 12 1.552E+00 7.000E+00 3.9792E-04 3.9792E-04 3.9792E-04 9.9960E-01 9.9960E-01 9.9960E-01 9.9960E-01 13 1.631E+00 8.000E+00 1.3003E-04 1.3003E-04 1.3003E-04 9.9987E-01 9.9987E-01 9.9987E-01 9.9987E-01 14 1.710E+00 9.000E+00 4.2492E-05 4.2492E-05 4.2492E-05 9.9996E-01 9.9996E-01 9.9996E-01 9.9996E-01 15 1.789E+00 1.000E+01 1.3886E-05 1.3886E-05 1.3886E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 16 1.986E+00 1.250E+01 8.4763E-07 8.4763E-07 8.4763E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 17 2.184E+00 1.500E+01 5.1742E-08 5.1742E-08 5.1742E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 18 2.381E+00 1.750E+01 3.1585E-09 3.1585E-09 3.1585E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 19 2.578E+00 2.000E+01 1.9281E-10 1.9281E-10 1.9281E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 20 2.973E+00 2.500E+01 7.1846E-13 7.1846E-13 7.1846E-13 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 3.367E+00 3.000E+01 2.6772E-15 2.6772E-15 2.6772E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 3.762E+00 3.500E+01 9.9762E-18 9.9762E-18 9.9762E-18 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 1.000E+00 1.000E-01 8.8285E-01 8.8285E-01 8.8285E-01 4.1360E-01 4.1360E-01 4.1360E-01 4.1360E-01 25 1.000E+00 2.500E-01 7.0771E-01 7.0771E-01 7.0771E-01 4.9277E-01 4.9277E-01 4.9277E-01 4.9277E-01 26 1.000E+00 5.000E-01 4.6901E-01 4.6901E-01 4.6901E-01 6.2562E-01 6.2562E-01 6.2562E-01 6.2562E-01 27 1.001E+00 1.000E+00 1.9683E-01 1.9683E-01 1.9683E-01 8.2133E-01 8.2133E-01 8.2133E-01 8.2133E-01 28 1.001E+00 1.500E+00 8.1770E-02 8.1770E-02 8.1770E-02 9.2148E-01 9.2148E-01 9.2148E-01 9.2148E-01 29 1.001E+00 2.000E+00 3.3940E-02 3.3940E-02 3.3940E-02 9.6663E-01 9.6663E-01 9.6663E-01 9.6663E-01 30 1.002E+00 3.000E+00 5.8462E-03 5.8462E-03 5.8462E-03 9.9417E-01 9.9417E-01 9.9417E-01 9.9417E-01 31 1.002E+00 4.000E+00 1.0070E-03 1.0070E-03 1.0070E-03 9.9899E-01 9.9899E-01 9.9899E-01 9.9899E-01 32 1.003E+00 5.000E+00 1.7345E-04 1.7345E-04 1.7345E-04 9.9983E-01 9.9983E-01 9.9983E-01 9.9983E-01 33 1.004E+00 6.000E+00 2.9877E-05 2.9877E-05 2.9877E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 34 1.004E+00 7.000E+00 5.1463E-06 5.1463E-06 5.1463E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 35 1.005E+00 8.000E+00 8.8645E-07 8.8645E-07 8.8645E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 36 1.006E+00 9.000E+00 1.5269E-07 1.5269E-07 1.5269E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 37 1.006E+00 1.000E+01 2.6301E-08 2.6301E-08 2.6301E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 38 1.008E+00 1.250E+01 3.2386E-10 3.2386E-10 3.2386E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 39 1.009E+00 1.500E+01 3.9879E-12 3.9879E-12 3.9879E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 40 1.011E+00 1.750E+01 4.9106E-14 4.9106E-14 4.9106E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 1.012E+00 2.000E+01 6.0468E-16 6.0468E-16 6.0468E-16 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 1.016E+00 2.500E+01 9.1687E-20 9.1687E-20 9.1687E-20 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 1.019E+00 3.000E+01 1.3902E-23 1.3902E-23 1.3902E-23 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 1.022E+00 3.500E+01 2.1080E-27 2.1080E-27 2.1080E-27 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 1.894E-01 7.891E-03 0.0000E+00 1.0000E-01 0.0000E+00 5.2800E-01 3 4.735E-01 1.973E-02 0.0000E+00 2.5000E-01 0.0000E+00 5.2800E-01 4 9.470E-01 3.946E-02 0.0000E+00 5.0000E-01 0.0000E+00 5.2800E-01 5 1.894E+00 7.891E-02 0.0000E+00 1.0000E+00 0.0000E+00 5.2800E-01 6 2.841E+00 1.184E-01 0.0000E+00 1.5000E+00 0.0000E+00 5.2800E-01 7 3.788E+00 1.578E-01 0.0000E+00 2.0000E+00 0.0000E+00 5.2800E-01 8 5.682E+00 2.367E-01 0.0000E+00 3.0000E+00 0.0000E+00 5.2800E-01 9 7.576E+00 3.157E-01 0.0000E+00 4.0000E+00 0.0000E+00 5.2800E-01 10 9.470E+00 3.946E-01 0.0000E+00 5.0000E+00 0.0000E+00 5.2800E-01 11 1.136E+01 4.735E-01 0.0000E+00 6.0000E+00 0.0000E+00 5.2800E-01 12 1.326E+01 5.524E-01 0.0000E+00 7.0000E+00 0.0000E+00 5.2800E-01 13 1.515E+01 6.313E-01 0.0000E+00 8.0000E+00 0.0000E+00 5.2800E-01 14 1.705E+01 7.102E-01 0.0000E+00 9.0000E+00 0.0000E+00 5.2800E-01 15 1.894E+01 7.891E-01 0.0000E+00 1.0000E+01 0.0000E+00 5.2800E-01 16 2.367E+01 9.864E-01 0.0000E+00 1.2500E+01 0.0000E+00 5.2800E-01 17 2.841E+01 1.184E+00 0.0000E+00 1.5000E+01 0.0000E+00 5.2800E-01 18 3.314E+01 1.381E+00 0.0000E+00 1.7500E+01 0.0000E+00 5.2800E-01 19 3.788E+01 1.578E+00 0.0000E+00 2.0000E+01 0.0000E+00 5.2800E-01 20 4.735E+01 1.973E+00 0.0000E+00 2.5000E+01 0.0000E+00 5.2800E-01 21 5.682E+01 2.367E+00 0.0000E+00 3.0000E+01 0.0000E+00 5.2800E-01 22 6.629E+01 2.762E+00 0.0000E+00 3.5000E+01 0.0000E+00 5.2800E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.488E-03 6.200E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.7200E+01 25 3.720E-03 1.550E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.7200E+01 26 7.440E-03 3.100E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.7200E+01 27 1.488E-02 6.200E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.7200E+01 28 2.232E-02 9.301E-04 0.0000E+00 1.5000E+00 0.0000E+00 6.7200E+01 29 2.976E-02 1.240E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.7200E+01 30 4.464E-02 1.860E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.7200E+01 31 5.952E-02 2.480E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.7200E+01 32 7.440E-02 3.100E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.7200E+01 33 8.929E-02 3.720E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.7200E+01 34 1.042E-01 4.340E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.7200E+01 35 1.190E-01 4.960E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.7200E+01 36 1.339E-01 5.580E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.7200E+01 37 1.488E-01 6.200E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.7200E+01 38 1.860E-01 7.750E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.7200E+01 39 2.232E-01 9.301E-03 0.0000E+00 1.5000E+01 0.0000E+00 6.7200E+01 40 2.604E-01 1.085E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.7200E+01 41 2.976E-01 1.240E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.7200E+01 42 3.720E-01 1.550E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.7200E+01 43 4.464E-01 1.860E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.7200E+01 44 5.208E-01 2.170E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.7200E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 6.76667E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 07:17:55 PM