VC 2.00I 15-JUL-2003 02-AUG-2003 07:32:33 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\ht144.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\ht144.radx (10 exposures) XDAT: ..\xdat\ht144.xdat (10 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E+01 2.00000E-04 2.4665271E+00 2201 CLRP RHT 1.00000E-03 2.40000E+01 1.50000E-01 1.0000000E-03 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 3.2974681E-02 2202 CLRP RHT 1.00000E-03 2.40000E+01 1.00000E+00 1.0000000E-03 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 2.80718E-02 (nfom=1096, nsim=10960, nmx=10, nox=10, ndf=5, nap=4) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-2.898E-01 max=6.542E-01, mean=9.0148E-02, stdev=2.8023E-01, var=7.8529E-02 Student's T test (mean=0, NDF=5): Pr>ABS(1.01728)= 3.5569E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.89507)=1.843E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-9.164E-02 max=2.069E-01, mean=2.8507E-02, stdev=8.8616E-02, var=7.8529E-03 Student's T test (mean=0, NDF=5): Pr>ABS(1.01728)= 3.5569E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.89507)=1.843E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 12.00000 h Potential doubling time (Tpot): 1008.00000 h (= 42.000 days) Cell birth rate (AX): 1.3863E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.3698E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 1.6504E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 1.93802E-11 1.19111E-02 67.500000 Complex DSB = 6.46006E-12 3.97035E-03 22.500000 Total DSB = 2.58403E-11 1.58814E-02 90.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 3.297468E-02 (=3.297%) PHI2= 3.297468E-02 (=3.297%) (1-A1)*PHI1= 8.243670E-03 (=0.824%) (1-A2)*PHI2= 2.473101E-02 (=2.473%) (1-A1)*(1-PHI1)= 2.417563E-01 (=24.176%) (1-A2)*(1-PHI2)= 7.252690E-01 (=72.527%) RHT1= 0.001000 h (=0.06 minute) RHT2= 0.001000 h (=0.06 minute) LAM1= 6.9314718E+02 (1/h) LAM2= 6.9314718E+02 (1/h) BMR= 2.4665271E+00 (1/h) LAM1/BMR= 2.8102151E+02 LAM2/BMR= 2.8102151E+02 (LAM1+LAM2)/BMR= 5.6204303E+02 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 5.5645E-01 + 5.5645E-01 = 1.1128955E+00 (1/Gy) beta: 2.5908E+00 + 8.3390E-01 = 3.4247189E+00 (1/Gy^2) alpha/beta: 0.3249597 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (HT 144 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 1.9272E+00 1.0175E+00 5.2800E-01 3.20250E-01 1.00E-01 3.20550E-01 9.3476E-04 2 3.8211E+00 2.0175E+00 5.2800E-01 8.81160E-02 1.00E-01 1.04787E-01 1.5909E-01 3 7.6422E+00 4.0351E+00 5.2800E-01 1.05190E-02 1.00E-01 1.09801E-02 4.1993E-02 4 1.1463E+01 6.0526E+00 5.2800E-01 1.48400E-03 1.00E-01 1.15056E-03 -2.8980E-01 5 1.5251E+01 8.0526E+00 5.2800E-01 4.25180E-05 1.00E-01 1.22951E-04 6.5419E-01 6 1.5403E-02 1.0351E+00 6.7200E+01 9.22220E-02 1.00E-01 1.75087E-01 4.7328E-01 7 3.0284E-02 2.0351E+00 6.7200E+01 3.43770E-02 1.00E-01 3.07729E-02 -1.1712E-01 8 4.5165E-02 3.0351E+00 6.7200E+01 5.90780E-03 1.00E-01 5.40855E-03 -9.2308E-02 9 6.0307E-02 4.0526E+00 6.7200E+01 8.99180E-04 1.00E-01 9.22039E-04 2.4792E-02 10 7.5188E-02 5.0526E+00 6.7200E+01 1.54530E-04 1.00E-01 1.62055E-04 4.6434E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-2.898E-01 max=6.542E-01, mean=9.0148E-02, stdev=2.8023E-01, var=7.8529E-02 Student's T test (mean=0, NDF=5): Pr>ABS(1.01728)= 3.5569E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.89507)=1.843E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-9.164E-02 max=2.069E-01, mean=2.8507E-02, stdev=8.8616E-02, var=7.8529E-03 Student's T test (mean=0, NDF=5): Pr>ABS(1.01728)= 3.5569E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.89507)=1.843E-01 (passed normality test) NOX=10, NPAR=4 CFE.SF: Cell survival data for HT 144 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 1.9272E+00 1.0175E+00 5.2800E-01 6.79750E-01 3.20250E-01 1.00E+01 2 2 3.8211E+00 2.0175E+00 5.2800E-01 9.11884E-01 8.81160E-02 1.00E+01 3 3 7.6422E+00 4.0351E+00 5.2800E-01 9.89481E-01 1.05190E-02 1.00E+01 4 4 1.1463E+01 6.0526E+00 5.2800E-01 9.98516E-01 1.48400E-03 1.00E+01 5 5 1.5251E+01 8.0526E+00 5.2800E-01 9.99957E-01 4.25180E-05 1.00E+01 6 6 1.5403E-02 1.0351E+00 6.7200E+01 9.07778E-01 9.22220E-02 1.00E+01 7 7 3.0284E-02 2.0351E+00 6.7200E+01 9.65623E-01 3.43770E-02 1.00E+01 8 8 4.5165E-02 3.0351E+00 6.7200E+01 9.94092E-01 5.90780E-03 1.00E+01 9 9 6.0307E-02 4.0526E+00 6.7200E+01 9.99101E-01 8.99180E-04 1.00E+01 10 10 7.5188E-02 5.0526E+00 6.7200E+01 9.99845E-01 1.54530E-04 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (HT 144). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 1.927E+00 1.200E+01 4.000E+02 1.0175E+00 1.1190E+00 1.1387E+00 2 2 3.821E+00 1.200E+01 4.000E+02 2.0175E+00 1.2040E+00 2.4291E+00 3 3 7.642E+00 1.200E+01 4.000E+02 4.0351E+00 1.1287E+00 4.5546E+00 4 4 1.146E+01 1.200E+01 4.000E+02 6.0526E+00 1.0761E+00 6.5130E+00 5 5 1.525E+01 1.200E+01 4.000E+02 8.0526E+00 1.2500E+00 1.0066E+01 6 6 1.540E-02 1.200E+01 4.000E+02 1.0351E+00 2.3028E+00 2.3836E+00 7 7 3.028E-02 1.200E+01 4.000E+02 2.0351E+00 1.6561E+00 3.3704E+00 8 8 4.517E-02 1.200E+01 4.000E+02 3.0351E+00 1.6907E+00 5.1315E+00 9 9 6.031E-02 1.200E+01 4.000E+02 4.0526E+00 1.7307E+00 7.0140E+00 10 10 7.519E-02 1.200E+01 4.000E+02 5.0526E+00 1.7367E+00 8.7751E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.77995 VC 2.00I 15-JUL-2003 02-AUG-2003 07:33:19 PM