VC 2.00I 15-JUL-2003 02-AUG-2003 07:13:00 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc rmr.inp ..\xdat\ht144.xdat -c FNI: rmr.inp FNO: rmr.out RADX: ..\xdat\ht144.radx (10 exposures) XDAT: ..\xdat\ht144.xdat (10 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E+00 1.00000E-04 4.8929477E-01 2401 CLRP PHI 0.00000E+00 1.00000E+00 1.00000E-02 1.2367501E-02 2201 CLRP RHT 1.00000E-03 2.40000E+01 2.00000E+00 2.2829899E-03 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 2.83421E-02 (nfom=3191, nsim=31910, nmx=10, nox=10, ndf=6, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-2.926E-01 max=6.532E-01, mean=9.5297E-02, stdev=2.8136E-01, var=7.9162E-02 Student's T test (mean=0, NDF=6): Pr>ABS(1.07107)= 3.2532E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.87016)=9.599E-02 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-9.252E-02 max=2.066E-01, mean=3.0135E-02, stdev=8.8973E-02, var=7.9162E-03 Student's T test (mean=0, NDF=6): Pr>ABS(1.07107)= 3.2532E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.87016)=9.599E-02 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- RMRM TABLE: Summary of RMR parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 2.58403E-11 1.58814E-02 90.000000 DAMAGE REPAIR/MISREPAIR: A0= 0.000000E+00 (=0.000%) (1-A0)*PHI= 1.236750E-02 (=1.237%) (1-A0)*(1-PHI)= 9.876325E-01 (=98.763%) RHT= 0.002283 h (=0.14 minute) LAM= 3.0361378E+02 (1/h) BMR= 4.8929477E-01 (1/h) LAM/BMR= 6.2051303E+02 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 1.113075 (1/Gy) beta = 1.550993 (1/Gy^2) alpha/beta = 0.717653 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (HT 144 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 1.9272E+00 1.0175E+00 5.2800E-01 3.20250E-01 1.00E-01 3.20435E-01 5.7778E-04 2 3.8211E+00 2.0175E+00 5.2800E-01 8.81160E-02 1.00E-01 1.04712E-01 1.5849E-01 3 7.6422E+00 4.0351E+00 5.2800E-01 1.05190E-02 1.00E-01 1.09644E-02 4.0619E-02 4 1.1463E+01 6.0526E+00 5.2800E-01 1.48400E-03 1.00E-01 1.14809E-03 -2.9258E-01 5 1.5251E+01 8.0526E+00 5.2800E-01 4.25180E-05 1.00E-01 1.22599E-04 6.5320E-01 6 1.5403E-02 1.0351E+00 6.7200E+01 9.22220E-02 1.00E-01 1.85077E-01 5.0171E-01 7 3.0284E-02 2.0351E+00 6.7200E+01 3.43770E-02 1.00E-01 3.19089E-02 -7.7349E-02 8 4.5165E-02 3.0351E+00 6.7200E+01 5.90780E-03 1.00E-01 5.49631E-03 -7.4867E-02 9 6.0307E-02 4.0526E+00 6.7200E+01 8.99180E-04 1.00E-01 9.17971E-04 2.0471E-02 10 7.5188E-02 5.0526E+00 6.7200E+01 1.54530E-04 1.00E-01 1.58119E-04 2.2701E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-2.926E-01 max=6.532E-01, mean=9.5297E-02, stdev=2.8136E-01, var=7.9162E-02 Student's T test (mean=0, NDF=6): Pr>ABS(1.07107)= 3.2532E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.87016)=9.599E-02 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-9.252E-02 max=2.066E-01, mean=3.0135E-02, stdev=8.8973E-02, var=7.9162E-03 Student's T test (mean=0, NDF=6): Pr>ABS(1.07107)= 3.2532E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.87016)=9.599E-02 (passed normality test) NOX=10, NPAR=3 CFE.SF: Cell survival data for HT 144 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 1.9272E+00 1.0175E+00 5.2800E-01 6.79750E-01 3.20250E-01 1.00E+01 2 2 3.8211E+00 2.0175E+00 5.2800E-01 9.11884E-01 8.81160E-02 1.00E+01 3 3 7.6422E+00 4.0351E+00 5.2800E-01 9.89481E-01 1.05190E-02 1.00E+01 4 4 1.1463E+01 6.0526E+00 5.2800E-01 9.98516E-01 1.48400E-03 1.00E+01 5 5 1.5251E+01 8.0526E+00 5.2800E-01 9.99957E-01 4.25180E-05 1.00E+01 6 6 1.5403E-02 1.0351E+00 6.7200E+01 9.07778E-01 9.22220E-02 1.00E+01 7 7 3.0284E-02 2.0351E+00 6.7200E+01 9.65623E-01 3.43770E-02 1.00E+01 8 8 4.5165E-02 3.0351E+00 6.7200E+01 9.94092E-01 5.90780E-03 1.00E+01 9 9 6.0307E-02 4.0526E+00 6.7200E+01 9.99101E-01 8.99180E-04 1.00E+01 10 10 7.5188E-02 5.0526E+00 6.7200E+01 9.99845E-01 1.54530E-04 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (HT 144). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 1.927E+00 1.200E+01 4.000E+02 1.0175E+00 1.1190E+00 1.1387E+00 2 2 3.821E+00 1.200E+01 4.000E+02 2.0175E+00 1.2040E+00 2.4291E+00 3 3 7.642E+00 1.200E+01 4.000E+02 4.0351E+00 1.1287E+00 4.5546E+00 4 4 1.146E+01 1.200E+01 4.000E+02 6.0526E+00 1.0761E+00 6.5130E+00 5 5 1.525E+01 1.200E+01 4.000E+02 8.0526E+00 1.2500E+00 1.0066E+01 6 6 1.540E-02 1.200E+01 4.000E+02 1.0351E+00 2.3028E+00 2.3836E+00 7 7 3.028E-02 1.200E+01 4.000E+02 2.0351E+00 1.6561E+00 3.3704E+00 8 8 4.517E-02 1.200E+01 4.000E+02 3.0351E+00 1.6907E+00 5.1315E+00 9 9 6.031E-02 1.200E+01 4.000E+02 4.0526E+00 1.7307E+00 7.0140E+00 10 10 7.519E-02 1.200E+01 4.000E+02 5.0526E+00 1.7367E+00 8.7751E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 1.2659 VC 2.00I 15-JUL-2003 02-AUG-2003 07:14:15 PM