VC 2.00J 25-SEP-2003 20-NOV-2003 01:07:29 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: p:\usr\bin\vc.exe p:\shared\rwx\djc\tsupr1\tlk\tsupr1.inp FNI: P:\shared\RWX\djc\tsupr1\tlk\tsupr1.inp FNO: P:\shared\RWX\djc\tsupr1\tlk\tsupr1.out RADX: P:\shared\RWX\djc\tsupr1\tlk\tsupr1.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 4.550000E-03 (=0.455%) PHI2= 4.550000E-03 (=0.455%) (1-A1)*PHI1= 4.550000E-03 (=0.455%) (1-A2)*PHI2= 4.550000E-03 (=0.455%) (1-A1)*(1-PHI1)= 9.954500E-01 (=99.545%) (1-A2)*(1-PHI2)= 9.954500E-01 (=99.545%) RHT1= 0.250000 h (=15.00 minute) RHT2= 12.192903 h (=731.57 minute) LAM1= 2.7725887E+00 (1/h) LAM2= 5.6848413E-02 (1/h) BMR= 1.3163500E-04 (1/h) LAM1/BMR= 2.1062702E+04 LAM2/BMR= 4.3186396E+02 (LAM1+LAM2)/BMR= 2.1494566E+04 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.3650E-01 + 4.5500E-02 = 1.8200000E-01 (1/Gy) beta: 8.6697E-03 + 3.1843E-02 = 4.0512998E-02 (1/Gy^2) alpha/beta: 4.4923854 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 1.856E-02 4.206E-03 2.2764E-02 9.774928E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 4.766E-02 1.030E-02 5.7959E-02 9.436884E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 9.916E-02 1.992E-02 1.1908E-01 8.877369E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 2.124E-01 3.729E-02 2.4967E-01 7.790603E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 3.378E-01 5.243E-02 3.9018E-01 6.769347E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 4.737E-01 6.563E-02 5.3936E-01 5.831203E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 7.723E-01 8.720E-02 8.5947E-01 4.233856E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 1.099E+00 1.036E-01 1.2028E+00 3.003590E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 1.448E+00 1.161E-01 1.5638E+00 2.093452E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 1.813E+00 1.257E-01 1.9383E+00 1.439548E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 2.190E+00 1.329E-01 2.3230E+00 9.797632E-02 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 2.577E+00 1.385E-01 2.7157E+00 6.616191E-02 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 2.972E+00 1.427E-01 3.1143E+00 4.441153E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 3.372E+00 1.459E-01 3.5174E+00 2.967572E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 4.388E+00 1.510E-01 4.5388E+00 1.068592E-02 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 5.418E+00 1.536E-01 5.5716E+00 3.804230E-03 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 6.455E+00 1.549E-01 6.6103E+00 1.346494E-03 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 7.496E+00 1.555E-01 7.6518E+00 4.751861E-04 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 9.583E+00 1.560E-01 9.7387E+00 5.895944E-05 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 1.167E+01 1.562E-01 1.1827E+01 7.302857E-06 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 1.376E+01 1.562E-01 1.3916E+01 9.041463E-07 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 1.859E-02 4.254E-03 2.2839E-02 9.774199E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 4.797E-02 1.059E-02 5.8568E-02 9.431140E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 1.009E-01 2.106E-02 1.2201E-01 8.851422E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 2.217E-01 4.161E-02 2.6326E-01 7.685435E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 3.616E-01 6.166E-02 4.2329E-01 6.548912E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 5.204E-01 8.123E-02 6.0164E-01 5.479124E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 8.926E-01 1.190E-01 1.0116E+00 3.636378E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 1.335E+00 1.551E-01 1.4898E+00 2.254142E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 1.844E+00 1.896E-01 2.0332E+00 1.309162E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 2.416E+00 2.226E-01 2.6388E+00 7.144389E-02 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 3.050E+00 2.541E-01 3.3040E+00 3.673483E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 3.742E+00 2.844E-01 4.0262E+00 1.784189E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 4.490E+00 3.134E-01 4.8030E+00 8.205333E-03 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 5.291E+00 3.413E-01 5.6321E+00 3.581166E-03 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 7.514E+00 4.064E-01 7.9201E+00 3.633680E-04 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 1.003E+01 4.655E-01 1.0492E+01 2.775360E-05 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 1.280E+01 5.196E-01 1.3322E+01 1.637894E-06 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 1.582E+01 5.691E-01 1.6387E+01 7.640957E-08 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 2.249E+01 6.566E-01 2.3145E+01 8.877092E-11 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 2.990E+01 7.316E-01 3.0632E+01 4.973615E-14 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 3.795E+01 7.966E-01 3.8743E+01 1.493032E-17 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 4.017E+00 1.000E-01 2.500E-01 9.7749E-01 9.7749E-01 1.0000E+00 9.7749E-01 9.7749E-01 9.8161E-01 3 4.042E+00 2.500E-01 2.500E-01 9.4369E-01 9.4369E-01 1.0000E+00 9.4369E-01 9.4369E-01 9.5346E-01 4 4.083E+00 5.000E-01 2.500E-01 8.8774E-01 8.8774E-01 1.0000E+00 8.8774E-01 8.8774E-01 9.0560E-01 5 4.167E+00 1.000E+00 2.500E-01 7.7906E-01 7.7906E-01 1.0000E+00 7.7906E-01 7.7906E-01 8.0866E-01 6 4.250E+00 1.500E+00 2.500E-01 6.7693E-01 6.7693E-01 1.0000E+00 6.7693E-01 6.7693E-01 7.1337E-01 7 4.333E+00 2.000E+00 2.500E-01 5.8312E-01 5.8312E-01 1.0000E+00 5.8312E-01 5.8312E-01 6.2268E-01 8 4.500E+00 3.000E+00 2.500E-01 4.2339E-01 4.2339E-01 1.0000E+00 4.2339E-01 4.2339E-01 4.6196E-01 9 4.667E+00 4.000E+00 2.500E-01 3.0036E-01 3.0036E-01 1.0000E+00 3.0036E-01 3.0036E-01 3.3315E-01 10 4.833E+00 5.000E+00 2.500E-01 2.0935E-01 2.0935E-01 1.0000E+00 2.0935E-01 2.0935E-01 2.3512E-01 11 5.000E+00 6.000E+00 2.500E-01 1.4395E-01 1.4395E-01 1.0000E+00 1.4395E-01 1.4395E-01 1.6323E-01 12 5.167E+00 7.000E+00 2.500E-01 9.7976E-02 9.7976E-02 1.0000E+00 9.7976E-02 9.7976E-02 1.1190E-01 13 5.333E+00 8.000E+00 2.500E-01 6.6162E-02 6.6162E-02 1.0000E+00 6.6162E-02 6.6162E-02 7.5987E-02 14 5.500E+00 9.000E+00 2.500E-01 4.4412E-02 4.4412E-02 1.0000E+00 4.4412E-02 4.4412E-02 5.1222E-02 15 5.667E+00 1.000E+01 2.500E-01 2.9676E-02 2.9676E-02 1.0000E+00 2.9676E-02 2.9676E-02 3.4337E-02 16 6.083E+00 1.250E+01 2.500E-01 1.0686E-02 1.0686E-02 1.0000E+00 1.0686E-02 1.0686E-02 1.2427E-02 17 6.500E+00 1.500E+01 2.500E-01 3.8042E-03 3.8042E-03 1.0000E+00 3.8042E-03 3.8042E-03 4.4356E-03 18 6.917E+00 1.750E+01 2.500E-01 1.3465E-03 1.3465E-03 1.0000E+00 1.3465E-03 1.3465E-03 1.5720E-03 19 7.333E+00 2.000E+01 2.500E-01 4.7519E-04 4.7519E-04 1.0000E+00 4.7519E-04 4.7519E-04 5.5515E-04 20 8.167E+00 2.500E+01 2.500E-01 5.8959E-05 5.8959E-05 1.0000E+00 5.8959E-05 5.8959E-05 6.8916E-05 21 9.000E+00 3.000E+01 2.500E-01 7.3029E-06 7.3029E-06 1.0000E+00 7.3029E-06 7.3029E-06 8.5373E-06 22 9.833E+00 3.500E+01 2.500E-01 9.0415E-07 9.0415E-07 1.0000E+00 9.0415E-07 9.0415E-07 1.0570E-06 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 4.000E+00 1.000E-01 6.000E+01 9.7742E-01 9.7742E-01 1.0000E+00 9.7742E-01 9.7742E-01 9.8159E-01 25 4.000E+00 2.500E-01 6.000E+01 9.4311E-01 9.4311E-01 1.0000E+00 9.4311E-01 9.4311E-01 9.5316E-01 26 4.000E+00 5.000E-01 6.000E+01 8.8514E-01 8.8514E-01 1.0000E+00 8.8514E-01 8.8514E-01 9.0398E-01 27 4.001E+00 1.000E+00 6.000E+01 7.6854E-01 7.6854E-01 1.0000E+00 7.6854E-01 7.6854E-01 8.0119E-01 28 4.001E+00 1.500E+00 6.000E+01 6.5489E-01 6.5489E-01 1.0000E+00 6.5489E-01 6.5489E-01 6.9654E-01 29 4.001E+00 2.000E+00 6.000E+01 5.4791E-01 5.4791E-01 1.0000E+00 5.4791E-01 5.4791E-01 5.9428E-01 30 4.002E+00 3.000E+00 6.000E+01 3.6364E-01 3.6364E-01 1.0000E+00 3.6364E-01 3.6364E-01 4.0960E-01 31 4.003E+00 4.000E+00 6.000E+01 2.2541E-01 2.2541E-01 1.0000E+00 2.2541E-01 2.2541E-01 2.6323E-01 32 4.003E+00 5.000E+00 6.000E+01 1.3092E-01 1.3092E-01 1.0000E+00 1.3092E-01 1.3092E-01 1.5824E-01 33 4.004E+00 6.000E+00 6.000E+01 7.1444E-02 7.1444E-02 1.0000E+00 7.1444E-02 7.1444E-02 8.9253E-02 34 4.005E+00 7.000E+00 6.000E+01 3.6735E-02 3.6735E-02 1.0000E+00 3.6735E-02 3.6735E-02 4.7364E-02 35 4.006E+00 8.000E+00 6.000E+01 1.7842E-02 1.7842E-02 1.0000E+00 1.7842E-02 1.7842E-02 2.3712E-02 36 4.006E+00 9.000E+00 6.000E+01 8.2053E-03 8.2053E-03 1.0000E+00 8.2053E-03 8.2053E-03 1.1226E-02 37 4.007E+00 1.000E+01 6.000E+01 3.5812E-03 3.5812E-03 1.0000E+00 3.5812E-03 3.5812E-03 5.0380E-03 38 4.009E+00 1.250E+01 6.000E+01 3.6337E-04 3.6337E-04 1.0000E+00 3.6337E-04 3.6337E-04 5.4555E-04 39 4.010E+00 1.500E+01 6.000E+01 2.7754E-05 2.7754E-05 1.0000E+00 2.7754E-05 2.7754E-05 4.4208E-05 40 4.012E+00 1.750E+01 6.000E+01 1.6379E-06 1.6379E-06 1.0000E+00 1.6379E-06 1.6379E-06 2.7538E-06 41 4.014E+00 2.000E+01 6.000E+01 7.6410E-08 7.6410E-08 1.0000E+00 7.6410E-08 7.6410E-08 1.3499E-07 42 4.017E+00 2.500E+01 6.000E+01 8.8771E-11 8.8771E-11 1.0000E+00 8.8771E-11 8.8771E-11 1.7118E-10 43 4.021E+00 3.000E+01 6.000E+01 4.9736E-14 4.9736E-14 1.0000E+00 4.9736E-14 4.9736E-14 1.0338E-13 44 4.024E+00 3.500E+01 6.000E+01 1.4930E-17 1.4930E-17 1.0000E+00 1.4930E-17 1.4930E-17 3.3114E-17 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 2.500E-01 3.977E+00 0.00E+00 3.97724E+00 1.652E-05 1.652E-05 1.690E-05 3 2.500E-01 2.500E-01 9.942E+00 0.00E+00 9.94204E+00 3.987E-05 3.987E-05 4.225E-05 4 5.000E-01 2.500E-01 1.988E+01 0.00E+00 1.98809E+01 7.501E-05 7.501E-05 8.449E-05 5 1.000E+00 2.500E-01 3.975E+01 0.00E+00 3.97503E+01 1.316E-04 1.316E-04 1.689E-04 6 1.500E+00 2.500E-01 5.961E+01 0.00E+00 5.96098E+01 1.715E-04 1.715E-04 2.533E-04 7 2.000E+00 2.500E-01 7.946E+01 0.00E+00 7.94606E+01 1.969E-04 1.969E-04 3.377E-04 8 3.000E+00 2.500E-01 1.191E+02 0.00E+00 1.19141E+02 2.143E-04 2.143E-04 5.062E-04 9 4.000E+00 2.500E-01 1.588E+02 0.00E+00 1.58797E+02 2.026E-04 2.026E-04 6.747E-04 10 5.000E+00 2.500E-01 1.984E+02 0.00E+00 1.98436E+02 1.765E-04 1.765E-04 8.430E-04 11 6.000E+00 2.500E-01 2.381E+02 0.00E+00 2.38062E+02 1.456E-04 1.456E-04 1.011E-03 12 7.000E+00 2.500E-01 2.777E+02 0.00E+00 2.77677E+02 1.156E-04 1.156E-04 1.179E-03 13 8.000E+00 2.500E-01 3.173E+02 0.00E+00 3.17284E+02 8.916E-05 8.916E-05 1.348E-03 14 9.000E+00 2.500E-01 3.569E+02 0.00E+00 3.56886E+02 6.731E-05 6.731E-05 1.516E-03 15 1.000E+01 2.500E-01 3.965E+02 0.00E+00 3.96483E+02 4.996E-05 4.996E-05 1.684E-03 16 1.250E+01 2.500E-01 4.955E+02 0.00E+00 4.95461E+02 2.248E-05 2.248E-05 2.103E-03 17 1.500E+01 2.500E-01 5.944E+02 0.00E+00 5.94428E+02 9.599E-06 9.599E-06 2.523E-03 18 1.750E+01 2.500E-01 6.934E+02 0.00E+00 6.93390E+02 3.962E-06 3.962E-06 2.943E-03 19 2.000E+01 2.500E-01 7.923E+02 0.00E+00 7.92348E+02 1.597E-06 1.597E-06 3.362E-03 20 2.500E+01 2.500E-01 9.903E+02 0.00E+00 9.90261E+02 2.476E-07 2.476E-07 4.200E-03 21 3.000E+01 2.500E-01 1.188E+03 0.00E+00 1.18817E+03 3.678E-08 3.678E-08 5.037E-03 22 3.500E+01 2.500E-01 1.386E+03 0.00E+00 1.38608E+03 5.311E-09 5.311E-09 5.874E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.000E+01 3.977E+00 0.00E+00 3.97716E+00 1.652E-05 1.652E-05 1.690E-05 25 2.500E-01 6.000E+01 9.941E+00 0.00E+00 9.94143E+00 3.985E-05 3.985E-05 4.225E-05 26 5.000E-01 6.000E+01 1.988E+01 0.00E+00 1.98780E+01 7.477E-05 7.477E-05 8.448E-05 27 1.000E+00 6.000E+01 3.974E+01 0.00E+00 3.97367E+01 1.298E-04 1.298E-04 1.689E-04 28 1.500E+00 6.000E+01 5.958E+01 0.00E+00 5.95767E+01 1.658E-04 1.658E-04 2.532E-04 29 2.000E+00 6.000E+01 7.940E+01 0.00E+00 7.93984E+01 1.849E-04 1.849E-04 3.374E-04 30 3.000E+00 6.000E+01 1.190E+02 0.00E+00 1.18988E+02 1.838E-04 1.838E-04 5.056E-04 31 4.000E+00 6.000E+01 1.585E+02 0.00E+00 1.58510E+02 1.518E-04 1.518E-04 6.734E-04 32 5.000E+00 6.000E+01 1.980E+02 0.00E+00 1.97967E+02 1.101E-04 1.101E-04 8.410E-04 33 6.000E+00 6.000E+01 2.374E+02 0.00E+00 2.37361E+02 7.204E-05 7.204E-05 1.008E-03 34 7.000E+00 6.000E+01 2.767E+02 0.00E+00 2.76696E+02 4.317E-05 4.317E-05 1.175E-03 35 8.000E+00 6.000E+01 3.160E+02 0.00E+00 3.15974E+02 2.394E-05 2.394E-05 1.342E-03 36 9.000E+00 6.000E+01 3.552E+02 0.00E+00 3.55197E+02 1.238E-05 1.238E-05 1.508E-03 37 1.000E+01 6.000E+01 3.944E+02 0.00E+00 3.94368E+02 5.997E-06 5.997E-06 1.675E-03 38 1.250E+01 6.000E+01 4.921E+02 0.00E+00 4.92080E+02 7.591E-07 7.591E-07 2.089E-03 39 1.500E+01 6.000E+01 5.895E+02 0.00E+00 5.89508E+02 6.945E-08 6.945E-08 2.502E-03 40 1.750E+01 6.000E+01 6.867E+02 0.00E+00 6.86678E+02 4.773E-09 4.773E-09 2.914E-03 41 2.000E+01 6.000E+01 7.836E+02 0.00E+00 7.83613E+02 2.540E-10 2.540E-10 3.325E-03 42 2.500E+01 6.000E+01 9.769E+02 0.00E+00 9.76855E+02 3.678E-13 3.678E-13 4.143E-03 43 3.000E+01 6.000E+01 1.169E+03 0.00E+00 1.16937E+03 2.466E-16 2.466E-16 4.957E-03 44 3.500E+01 6.000E+01 1.361E+03 0.00E+00 1.36126E+03 8.613E-20 8.613E-20 5.769E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 2.500E-01 3.977E+00 1.652E-05 1.690E-05 6.8994E-05 6.9196E-05 6.7638E-05 3 2.500E-01 2.500E-01 9.942E+00 3.987E-05 4.225E-05 6.8992E-05 6.9496E-05 6.5583E-05 4 5.000E-01 2.500E-01 1.988E+01 7.501E-05 8.449E-05 6.8989E-05 6.9997E-05 6.2139E-05 5 1.000E+00 2.500E-01 3.975E+01 1.316E-04 1.689E-04 6.8984E-05 7.0999E-05 5.5312E-05 6 1.500E+00 2.500E-01 5.961E+01 1.715E-04 2.533E-04 6.8978E-05 7.1999E-05 4.8739E-05 7 2.000E+00 2.500E-01 7.946E+01 1.969E-04 3.377E-04 6.8972E-05 7.3000E-05 4.2568E-05 8 3.000E+00 2.500E-01 1.191E+02 2.143E-04 5.062E-04 6.8960E-05 7.4999E-05 3.1753E-05 9 4.000E+00 2.500E-01 1.588E+02 2.026E-04 6.747E-04 6.8949E-05 7.6996E-05 2.3127E-05 10 5.000E+00 2.500E-01 1.984E+02 1.765E-04 8.430E-04 6.8937E-05 7.8993E-05 1.6537E-05 11 6.000E+00 2.500E-01 2.381E+02 1.456E-04 1.011E-03 6.8925E-05 8.0988E-05 1.1659E-05 12 7.000E+00 2.500E-01 2.777E+02 1.156E-04 1.179E-03 6.8914E-05 8.2982E-05 8.1303E-06 13 8.000E+00 2.500E-01 3.173E+02 8.916E-05 1.348E-03 6.8902E-05 8.4976E-05 5.6222E-06 14 9.000E+00 2.500E-01 3.569E+02 6.731E-05 1.516E-03 6.8891E-05 8.6969E-05 3.8624E-06 15 1.000E+01 2.500E-01 3.965E+02 4.996E-05 1.684E-03 6.8879E-05 8.8962E-05 2.6400E-06 16 1.250E+01 2.500E-01 4.955E+02 2.248E-05 2.103E-03 6.8850E-05 9.3941E-05 1.0038E-06 17 1.500E+01 2.500E-01 5.944E+02 9.599E-06 2.523E-03 6.8821E-05 9.8918E-05 3.7631E-07 18 1.750E+01 2.500E-01 6.934E+02 3.962E-06 2.943E-03 6.8792E-05 1.0389E-04 1.3989E-07 19 2.000E+01 2.500E-01 7.923E+02 1.597E-06 3.362E-03 6.8763E-05 1.0886E-04 5.1731E-08 20 2.500E+01 2.500E-01 9.903E+02 2.476E-07 4.200E-03 6.8705E-05 1.1880E-04 7.0045E-09 21 3.000E+01 2.500E-01 1.188E+03 3.678E-08 5.037E-03 6.8648E-05 1.2873E-04 9.4010E-10 22 3.500E+01 2.500E-01 1.386E+03 5.311E-09 5.874E-03 6.8590E-05 1.3865E-04 1.2536E-10 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.000E+01 3.977E+00 1.652E-05 1.690E-05 6.8994E-05 6.9196E-05 6.7633E-05 25 2.500E-01 6.000E+01 9.941E+00 3.985E-05 4.225E-05 6.8992E-05 6.9496E-05 6.5543E-05 26 5.000E-01 6.000E+01 1.988E+01 7.477E-05 8.448E-05 6.8989E-05 6.9997E-05 6.1957E-05 27 1.000E+00 6.000E+01 3.974E+01 1.298E-04 1.689E-04 6.8984E-05 7.0998E-05 5.4565E-05 28 1.500E+00 6.000E+01 5.958E+01 1.658E-04 2.532E-04 6.8978E-05 7.1998E-05 4.7151E-05 29 2.000E+00 6.000E+01 7.940E+01 1.849E-04 3.374E-04 6.8972E-05 7.2996E-05 3.9996E-05 30 3.000E+00 6.000E+01 1.190E+02 1.838E-04 5.056E-04 6.8960E-05 7.4991E-05 2.7270E-05 31 4.000E+00 6.000E+01 1.585E+02 1.518E-04 6.734E-04 6.8949E-05 7.6982E-05 1.7353E-05 32 5.000E+00 6.000E+01 1.980E+02 1.101E-04 8.410E-04 6.8937E-05 7.8969E-05 1.0338E-05 33 6.000E+00 6.000E+01 2.374E+02 7.204E-05 1.008E-03 6.8926E-05 8.0953E-05 5.7836E-06 34 7.000E+00 6.000E+01 2.767E+02 4.317E-05 1.175E-03 6.8914E-05 8.2933E-05 3.0465E-06 35 8.000E+00 6.000E+01 3.160E+02 2.394E-05 1.342E-03 6.8903E-05 8.4910E-05 1.5150E-06 36 9.000E+00 6.000E+01 3.552E+02 1.238E-05 1.508E-03 6.8891E-05 8.6884E-05 7.1292E-07 37 1.000E+01 6.000E+01 3.944E+02 5.997E-06 1.675E-03 6.8880E-05 8.8856E-05 3.1821E-07 38 1.250E+01 6.000E+01 4.921E+02 7.591E-07 2.089E-03 6.8851E-05 9.3771E-05 3.4073E-08 39 1.500E+01 6.000E+01 5.895E+02 6.945E-08 2.502E-03 6.8823E-05 9.8670E-05 2.7385E-09 40 1.750E+01 6.000E+01 6.867E+02 4.773E-09 2.914E-03 6.8794E-05 1.0355E-04 1.6961E-10 41 2.000E+01 6.000E+01 7.836E+02 2.540E-10 3.325E-03 6.8766E-05 1.0843E-04 8.2847E-12 42 2.500E+01 6.000E+01 9.769E+02 3.678E-13 4.143E-03 6.8709E-05 1.1813E-04 1.0486E-14 43 3.000E+01 6.000E+01 1.169E+03 2.466E-16 4.957E-03 6.8653E-05 1.2779E-04 6.3557E-18 44 3.500E+01 6.000E+01 1.361E+03 8.613E-20 5.769E-03 6.8597E-05 1.3741E-04 2.0515E-21 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.1820 (1/Gy), alpha/beta = 4.4924 (Gy), lamda1 = 2.773E+00 (1/h), lamda2 = 5.685E-02 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 7.137E-01 9.925E-01 1.127E+01 9.8159E-01 9.774928E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 4.774E-01 9.813E-01 4.921E+00 9.5341E-01 9.436884E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 2.959E-01 9.632E-01 2.772E+00 9.0546E-01 8.877369E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 1.641E-01 9.283E-01 1.670E+00 8.0817E-01 7.790603E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 1.130E-01 8.954E-01 1.286E+00 7.1223E-01 6.769347E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 8.610E-02 8.642E-01 1.082E+00 6.2061E-01 5.831203E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 5.831E-02 8.066E-01 8.597E-01 4.5762E-01 4.233856E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 4.407E-02 7.549E-01 7.324E-01 3.2670E-01 3.003590E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 3.542E-02 7.082E-01 6.455E-01 2.2730E-01 2.093452E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 2.960E-02 6.660E-01 5.802E-01 1.5493E-01 1.439548E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 2.543E-02 6.278E-01 5.284E-01 1.0390E-01 9.797632E-02 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 2.229E-02 5.931E-01 4.858E-01 6.8768E-02 6.616191E-02 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 1.984E-02 5.614E-01 4.499E-01 4.5048E-02 4.441153E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 1.787E-02 5.325E-01 4.190E-01 2.9267E-02 2.967572E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 1.432E-02 4.705E-01 3.576E-01 9.7020E-03 1.068592E-02 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 1.195E-02 4.201E-01 3.117E-01 3.1405E-03 3.804230E-03 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 1.025E-02 3.787E-01 2.761E-01 1.0029E-03 1.346494E-03 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 8.976E-03 3.441E-01 2.476E-01 3.1785E-04 4.751861E-04 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 7.187E-03 2.901E-01 2.049E-01 3.1571E-05 5.895944E-05 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 5.993E-03 2.502E-01 1.746E-01 3.1171E-06 7.302857E-06 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 5.139E-03 2.197E-01 1.521E-01 3.0717E-07 9.041463E-07 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 9.985E-01 1.000E+00 1.145E+01 9.8157E-01 9.774199E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 9.962E-01 9.999E-01 5.161E+00 9.5311E-01 9.431140E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.923E-01 9.998E-01 3.061E+00 9.0383E-01 8.851422E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 9.848E-01 9.997E-01 2.006E+00 8.0062E-01 7.685435E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 9.773E-01 9.995E-01 1.649E+00 6.9512E-01 6.548912E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.699E-01 9.994E-01 1.466E+00 5.9160E-01 5.479124E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 9.553E-01 9.991E-01 1.277E+00 4.0379E-01 3.636378E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 9.411E-01 9.987E-01 1.175E+00 2.5477E-01 2.254142E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 9.272E-01 9.984E-01 1.109E+00 1.4870E-01 1.309162E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 9.136E-01 9.981E-01 1.061E+00 8.0351E-02 7.144389E-02 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 9.004E-01 9.978E-01 1.023E+00 4.0221E-02 3.673483E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 8.874E-01 9.975E-01 9.913E-01 1.8663E-02 1.784189E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 8.747E-01 9.972E-01 9.645E-01 8.0328E-03 8.205333E-03 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 8.622E-01 9.968E-01 9.409E-01 3.2089E-03 3.581166E-03 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 8.323E-01 9.961E-01 8.918E-01 2.3441E-04 3.633680E-04 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 8.040E-01 9.953E-01 8.515E-01 1.0872E-05 2.775360E-05 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 7.772E-01 9.945E-01 8.170E-01 3.2260E-07 1.637894E-06 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 7.517E-01 9.937E-01 7.866E-01 6.1661E-09 7.640957E-08 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 7.047E-01 9.922E-01 7.344E-01 6.1685E-13 8.877092E-11 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 6.622E-01 9.906E-01 6.904E-01 1.1363E-17 4.973615E-14 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 6.237E-01 9.890E-01 6.523E-01 3.9944E-23 1.493032E-17 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 4.017E+00 1.000E-01 9.7749E-01 9.7749E-01 9.8161E-01 3.7625E-01 3.7625E-01 3.7471E-01 3.7471E-01 3 4.042E+00 2.500E-01 9.4369E-01 9.4369E-01 9.5346E-01 3.8919E-01 3.8919E-01 3.8540E-01 3.8540E-01 4 4.083E+00 5.000E-01 8.8774E-01 8.8774E-01 9.0560E-01 4.1159E-01 4.1159E-01 4.0430E-01 4.0430E-01 5 4.167E+00 1.000E+00 7.7906E-01 7.7906E-01 8.0866E-01 4.5884E-01 4.5884E-01 4.4546E-01 4.4546E-01 6 4.250E+00 1.500E+00 6.7693E-01 6.7693E-01 7.1337E-01 5.0817E-01 5.0817E-01 4.8999E-01 4.8999E-01 7 4.333E+00 2.000E+00 5.8312E-01 5.8312E-01 6.2268E-01 5.5815E-01 5.5815E-01 5.3651E-01 5.3651E-01 8 4.500E+00 3.000E+00 4.2339E-01 4.2339E-01 4.6196E-01 6.5483E-01 6.5483E-01 6.3004E-01 6.3004E-01 9 4.667E+00 4.000E+00 3.0036E-01 3.0036E-01 3.3315E-01 7.4055E-01 7.4055E-01 7.1666E-01 7.1666E-01 10 4.833E+00 5.000E+00 2.0935E-01 2.0935E-01 2.3512E-01 8.1112E-01 8.1112E-01 7.9047E-01 7.9047E-01 11 5.000E+00 6.000E+00 1.4395E-01 1.4395E-01 1.6323E-01 8.6593E-01 8.6593E-01 8.4940E-01 8.4940E-01 12 5.167E+00 7.000E+00 9.7976E-02 9.7976E-02 1.1190E-01 9.0667E-01 9.0667E-01 8.9413E-01 8.9413E-01 13 5.333E+00 8.000E+00 6.6162E-02 6.6162E-02 7.5987E-02 9.3598E-01 9.3598E-01 9.2683E-01 9.2683E-01 14 5.500E+00 9.000E+00 4.4412E-02 4.4412E-02 5.1222E-02 9.5656E-01 9.5656E-01 9.5007E-01 9.5007E-01 15 5.667E+00 1.000E+01 2.9676E-02 2.9676E-02 3.4337E-02 9.7076E-01 9.7076E-01 9.6625E-01 9.6625E-01 16 6.083E+00 1.250E+01 1.0686E-02 1.0686E-02 1.2427E-02 9.8937E-01 9.8937E-01 9.8765E-01 9.8765E-01 17 6.500E+00 1.500E+01 3.8042E-03 3.8042E-03 4.4356E-03 9.9620E-01 9.9620E-01 9.9557E-01 9.9557E-01 18 6.917E+00 1.750E+01 1.3465E-03 1.3465E-03 1.5720E-03 9.9865E-01 9.9865E-01 9.9843E-01 9.9843E-01 19 7.333E+00 2.000E+01 4.7519E-04 4.7519E-04 5.5515E-04 9.9952E-01 9.9952E-01 9.9945E-01 9.9945E-01 20 8.167E+00 2.500E+01 5.8959E-05 5.8959E-05 6.8916E-05 9.9994E-01 9.9994E-01 9.9993E-01 9.9993E-01 21 9.000E+00 3.000E+01 7.3029E-06 7.3029E-06 8.5373E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 22 9.833E+00 3.500E+01 9.0415E-07 9.0415E-07 1.0570E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 4.000E+00 1.000E-01 9.7742E-01 9.7742E-01 9.8159E-01 3.7628E-01 3.7628E-01 3.7472E-01 3.7472E-01 25 4.000E+00 2.500E-01 9.4311E-01 9.4311E-01 9.5316E-01 3.8941E-01 3.8941E-01 3.8552E-01 3.8552E-01 26 4.000E+00 5.000E-01 8.8514E-01 8.8514E-01 9.0398E-01 4.1266E-01 4.1266E-01 4.0495E-01 4.0495E-01 27 4.001E+00 1.000E+00 7.6854E-01 7.6854E-01 8.0119E-01 4.6369E-01 4.6369E-01 4.4879E-01 4.4879E-01 28 4.001E+00 1.500E+00 6.5489E-01 6.5489E-01 6.9654E-01 5.1950E-01 5.1950E-01 4.9831E-01 4.9831E-01 29 4.001E+00 2.000E+00 5.4791E-01 5.4791E-01 5.9428E-01 5.7816E-01 5.7816E-01 5.5196E-01 5.5196E-01 30 4.002E+00 3.000E+00 3.6364E-01 3.6364E-01 4.0960E-01 6.9514E-01 6.9514E-01 6.6392E-01 6.6392E-01 31 4.003E+00 4.000E+00 2.2541E-01 2.2541E-01 2.6323E-01 7.9819E-01 7.9819E-01 7.6856E-01 7.6856E-01 32 4.003E+00 5.000E+00 1.3092E-01 1.3092E-01 1.5824E-01 8.7729E-01 8.7729E-01 8.5364E-01 8.5364E-01 33 4.004E+00 6.000E+00 7.1444E-02 7.1444E-02 8.9253E-02 9.3105E-01 9.3105E-01 9.1461E-01 9.1461E-01 34 4.005E+00 7.000E+00 3.6735E-02 3.6735E-02 4.7364E-02 9.6393E-01 9.6393E-01 9.5374E-01 9.5374E-01 35 4.006E+00 8.000E+00 1.7842E-02 1.7842E-02 2.3712E-02 9.8232E-01 9.8232E-01 9.7657E-01 9.7657E-01 36 4.006E+00 9.000E+00 8.2053E-03 8.2053E-03 1.1226E-02 9.9183E-01 9.9183E-01 9.8884E-01 9.8884E-01 37 4.007E+00 1.000E+01 3.5812E-03 3.5812E-03 5.0380E-03 9.9643E-01 9.9643E-01 9.9497E-01 9.9497E-01 38 4.009E+00 1.250E+01 3.6337E-04 3.6337E-04 5.4555E-04 9.9964E-01 9.9964E-01 9.9945E-01 9.9945E-01 39 4.010E+00 1.500E+01 2.7754E-05 2.7754E-05 4.4208E-05 9.9997E-01 9.9997E-01 9.9996E-01 9.9996E-01 40 4.012E+00 1.750E+01 1.6379E-06 1.6379E-06 2.7538E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 4.014E+00 2.000E+01 7.6410E-08 7.6410E-08 1.3499E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 4.017E+00 2.500E+01 8.8771E-11 8.8771E-11 1.7118E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.021E+00 3.000E+01 4.9736E-14 4.9736E-14 1.0338E-13 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.024E+00 3.500E+01 1.4930E-17 1.4930E-17 3.3114E-17 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 4.000E-01 1.667E-02 0.0000E+00 1.0000E-01 0.0000E+00 2.5000E-01 3 1.000E+00 4.167E-02 0.0000E+00 2.5000E-01 0.0000E+00 2.5000E-01 4 2.000E+00 8.333E-02 0.0000E+00 5.0000E-01 0.0000E+00 2.5000E-01 5 4.000E+00 1.667E-01 0.0000E+00 1.0000E+00 0.0000E+00 2.5000E-01 6 6.000E+00 2.500E-01 0.0000E+00 1.5000E+00 0.0000E+00 2.5000E-01 7 8.000E+00 3.333E-01 0.0000E+00 2.0000E+00 0.0000E+00 2.5000E-01 8 1.200E+01 5.000E-01 0.0000E+00 3.0000E+00 0.0000E+00 2.5000E-01 9 1.600E+01 6.667E-01 0.0000E+00 4.0000E+00 0.0000E+00 2.5000E-01 10 2.000E+01 8.333E-01 0.0000E+00 5.0000E+00 0.0000E+00 2.5000E-01 11 2.400E+01 1.000E+00 0.0000E+00 6.0000E+00 0.0000E+00 2.5000E-01 12 2.800E+01 1.167E+00 0.0000E+00 7.0000E+00 0.0000E+00 2.5000E-01 13 3.200E+01 1.333E+00 0.0000E+00 8.0000E+00 0.0000E+00 2.5000E-01 14 3.600E+01 1.500E+00 0.0000E+00 9.0000E+00 0.0000E+00 2.5000E-01 15 4.000E+01 1.667E+00 0.0000E+00 1.0000E+01 0.0000E+00 2.5000E-01 16 5.000E+01 2.083E+00 0.0000E+00 1.2500E+01 0.0000E+00 2.5000E-01 17 6.000E+01 2.500E+00 0.0000E+00 1.5000E+01 0.0000E+00 2.5000E-01 18 7.000E+01 2.917E+00 0.0000E+00 1.7500E+01 0.0000E+00 2.5000E-01 19 8.000E+01 3.333E+00 0.0000E+00 2.0000E+01 0.0000E+00 2.5000E-01 20 1.000E+02 4.167E+00 0.0000E+00 2.5000E+01 0.0000E+00 2.5000E-01 21 1.200E+02 5.000E+00 0.0000E+00 3.0000E+01 0.0000E+00 2.5000E-01 22 1.400E+02 5.833E+00 0.0000E+00 3.5000E+01 0.0000E+00 2.5000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.667E-03 6.944E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E+01 25 4.167E-03 1.736E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E+01 26 8.333E-03 3.472E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E+01 27 1.667E-02 6.944E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E+01 28 2.500E-02 1.042E-03 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E+01 29 3.333E-02 1.389E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E+01 30 5.000E-02 2.083E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E+01 31 6.667E-02 2.778E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E+01 32 8.333E-02 3.472E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E+01 33 1.000E-01 4.167E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E+01 34 1.167E-01 4.861E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E+01 35 1.333E-01 5.556E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E+01 36 1.500E-01 6.250E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E+01 37 1.667E-01 6.944E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E+01 38 2.083E-01 8.681E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E+01 39 2.500E-01 1.042E-02 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E+01 40 2.917E-01 1.215E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E+01 41 3.333E-01 1.389E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E+01 42 4.167E-01 1.736E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E+01 43 5.000E-01 2.083E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E+01 44 5.833E-01 2.431E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 8.06667E-03 VC 2.00J 25-SEP-2003 20-NOV-2003 01:07:30 PM