VC 2.00J 25-SEP-2003 20-NOV-2003 01:02:41 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\tsupr1.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\tsupr1.radx (8 exposures) XDAT: ..\xdat\tsupr1.xdat (8 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 1.3163500E-04 2202 CLRP RHT 1.00000E-03 2.40000E+01 8.00000E+00 1.2192903E+01 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 2.18028E-02 (nfom=57, nsim=456, nmx=8, nox=8, ndf=5, nap=2) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-3.334E-01 max=2.022E-01, mean=-7.5240E-03, stdev=1.8629E-01, var=3.4705E-02 Student's T test (mean=0, NDF=5): Pr>ABS(0.11424)= 9.1350E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93243)=5.430E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-1.179E-01 max=7.149E-02, mean=-2.6601E-03, stdev=6.5864E-02, var=4.3381E-03 Student's T test (mean=0, NDF=5): Pr>ABS(0.11424)= 9.1350E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93243)=5.430E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 4.550000E-03 (=0.455%) PHI2= 4.550000E-03 (=0.455%) (1-A1)*PHI1= 4.550000E-03 (=0.455%) (1-A2)*PHI2= 4.550000E-03 (=0.455%) (1-A1)*(1-PHI1)= 9.954500E-01 (=99.545%) (1-A2)*(1-PHI2)= 9.954500E-01 (=99.545%) RHT1= 0.250000 h (=15.00 minute) RHT2= 12.192903 h (=731.57 minute) LAM1= 2.7725887E+00 (1/h) LAM2= 5.6848412E-02 (1/h) BMR= 1.3163500E-04 (1/h) LAM1/BMR= 2.1062701E+04 LAM2/BMR= 4.3186395E+02 (LAM1+LAM2)/BMR= 2.1494565E+04 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.3650E-01 + 4.5500E-02 = 1.8200000E-01 (1/Gy) beta: 8.6697E-03 + 3.1843E-02 = 4.0512999E-02 (1/Gy^2) alpha/beta: 4.4923852 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (TSUPR1 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 2.4000E+01 6.0000E+00 2.5000E-01 1.91949E-01 1.25E-01 1.43955E-01 -3.3340E-01 2 4.7828E+01 1.1957E+01 2.5000E-01 1.37610E-02 1.25E-01 1.33567E-02 -3.0270E-02 3 7.1692E+01 1.7923E+01 2.5000E-01 9.32000E-04 1.25E-01 1.12911E-03 1.7457E-01 4 3.3762E-02 2.0257E+00 6.0000E+01 6.08920E-01 1.25E-01 5.42648E-01 -1.2213E-01 5 6.6705E-02 4.0023E+00 6.0000E+01 2.01070E-01 1.25E-01 2.25149E-01 1.0695E-01 6 9.9647E-02 5.9788E+00 6.0000E+01 6.53700E-02 1.25E-01 7.24125E-02 9.7255E-02 7 1.3284E-01 7.9707E+00 6.0000E+01 1.45500E-02 1.25E-01 1.82378E-02 2.0221E-01 8 1.6605E-01 9.9631E+00 6.0000E+01 4.27000E-03 1.25E-01 3.69576E-03 -1.5538E-01 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-3.334E-01 max=2.022E-01, mean=-7.5240E-03, stdev=1.8629E-01, var=3.4705E-02 Student's T test (mean=0, NDF=5): Pr>ABS(0.11424)= 9.1350E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93243)=5.430E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-1.179E-01 max=7.149E-02, mean=-2.6601E-03, stdev=6.5864E-02, var=4.3381E-03 Student's T test (mean=0, NDF=5): Pr>ABS(0.11424)= 9.1350E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93243)=5.430E-01 (passed normality test) NOX=8, NPAR=2 CFE.SF: Cell survival data for TSUPR1 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 2.4000E+01 6.0000E+00 2.5000E-01 8.08051E-01 1.91949E-01 1.00E+01 2 2 4.7828E+01 1.1957E+01 2.5000E-01 9.86239E-01 1.37610E-02 1.00E+01 3 3 7.1692E+01 1.7923E+01 2.5000E-01 9.99068E-01 9.32000E-04 1.00E+01 4 4 3.3762E-02 2.0257E+00 6.0000E+01 3.91080E-01 6.08920E-01 1.00E+01 5 5 6.6705E-02 4.0023E+00 6.0000E+01 7.98930E-01 2.01070E-01 1.00E+01 6 6 9.9647E-02 5.9788E+00 6.0000E+01 9.34630E-01 6.53700E-02 1.00E+01 7 7 1.3284E-01 7.9707E+00 6.0000E+01 9.85450E-01 1.45500E-02 1.00E+01 8 8 1.6605E-01 9.9631E+00 6.0000E+01 9.95730E-01 4.27000E-03 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (TSUPR1). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 2.400E+01 1.200E+01 4.000E+02 6.0000E+00 2.7509E-01 1.6505E+00 2 2 4.783E+01 1.200E+01 4.000E+02 1.1957E+01 3.5844E-01 4.2859E+00 3 3 7.169E+01 1.200E+01 4.000E+02 1.7923E+01 3.8934E-01 6.9782E+00 4 4 3.376E-02 1.200E+01 4.000E+02 2.0257E+00 2.4489E-01 4.9607E-01 5 5 6.671E-02 1.200E+01 4.000E+02 4.0023E+00 4.0080E-01 1.6041E+00 6 6 9.965E-02 1.200E+01 4.000E+02 5.9788E+00 4.5623E-01 2.7277E+00 7 7 1.328E-01 1.200E+01 4.000E+02 7.9707E+00 5.3071E-01 4.2302E+00 8 8 1.661E-01 1.200E+01 4.000E+02 9.9631E+00 5.4763E-01 5.4561E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 5.41667E-02 VC 2.00J 25-SEP-2003 20-NOV-2003 01:02:44 PM