/*
REFERENCE:
Algan O, Stobbe CC, Helt AM, Hanks GE, and Chapman JD. Radiation
Inactiviation of Human
Prostate Cancer Cells: The Role of Apoptosis Radiation Research. 146,
267-275 (1996)
PREPARED
BY: JULIEN PARTOUCHE (julien@tamu.edu)
DATE: 22-JUL-2003
REVISED: 02-AUG-2003 RD STEWART
Two-parameter fit with RHT=2 hour instead of three-parameter fit (not
enough data for 3P fit)
*/
MODEL: DRM=TLK CKM=QECK
CELL: DNA=5.667D+09 NC=46
IRAD: CL=DSB
CLRP: RHT=HT4R BMR=1.0608577E-04 PHI=PML A0=PMR
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data
! TLK model inputs (simple and complex double strand breaks)
DSB = 20 5 / !Radiation damage to DNA
HT4R = 4.2203266E+00 7 / !Half-times for DSB repair
PML = 9.1977346E-03 / !Probability a misrejoined DSB is lethal
PMR = 0.75 0.25 / !Probability DSB is rejoined correctly
! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10
! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09
!IRRADIATION CONDITIONS (single fraction)
RADX: ADR=RX1 AD=RX2
RX1 = 84 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 /
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