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Calibrated Input File (RMR)
TSU Prostate Carcinoma Cells

/*
 REFERENCE:
  Algan O, Stobbe CC, Helt AM, Hanks GE, and Chapman JD. Radiation Inactiviation of Human
  Prostate Cancer Cells: The Role of Apoptosis Radiation Research. 146, 267-275 (1996)
 

 PREPARED BY: JULIEN PARTOUCHE (julien@tamu.edu)
 DATE: 22-JUL-2003
 REVISED: 02-AUG-2003 RD STEWART
 Two-parameter fit with RHT=2 hour instead of three-parameter fit (not enough data for 3P fit)

*/

MODEL: DRM=RMR CKM=QECK !Model Specification
CELL: DNA=5.667D+09 NC=46
IRAD: CL=25 !Radiation damage to DNA
CLRP: RHT=2.0 BMR=2.4890480E-04 PHI=3.2073303E-03 A0=0.00
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data

! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10

! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0E+00 RCUT=1.0D-09


!IRRADIATION CONDITIONS (single fraction)
RADX: ADR=RX1 AD=RX2
RX1 = 84 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 /


 


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