VC 2.00I 15-JUL-2003 02-AUG-2003 02:29:10 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\tsu.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\tsu.radx (7 exposures) XDAT: ..\xdat\tsu.xdat (7 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 1.0608577E-04 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 9.1977346E-03 2201 CLRP RHT 1.00000E-02 1.20000E+01 1.50000E-01 4.2203266E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 9.74600E-03 (nfom=2004, nsim=14028, nmx=7, nox=7, ndf=3, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-6.951E-02 max=1.299E-01, mean=9.1566E-03, stdev=7.3021E-02, var=5.3321E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.33177)= 7.6189E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93402)=6.039E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-2.627E-02 max=4.910E-02, mean=3.4609E-03, stdev=2.7599E-02, var=7.6173E-04 Student's T test (mean=0, NDF=3): Pr>ABS(0.33177)= 7.6189E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93402)=6.039E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 5.74228E-12 3.52920E-03 20.000000 Complex DSB = 1.43557E-12 8.82301E-04 5.000000 Total DSB = 7.17785E-12 4.41151E-03 25.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 9.197735E-03 (=0.920%) PHI2= 9.197735E-03 (=0.920%) (1-A1)*PHI1= 2.299434E-03 (=0.230%) (1-A2)*PHI2= 6.898301E-03 (=0.690%) (1-A1)*(1-PHI1)= 2.477006E-01 (=24.770%) (1-A2)*(1-PHI2)= 7.431017E-01 (=74.310%) RHT1= 4.220327 h (=253.22 minute) RHT2= 7.000000 h (=420.00 minute) LAM1= 1.6424018E-01 (1/h) LAM2= 9.9021026E-02 (1/h) BMR= 1.0608577E-04 (1/h) LAM1/BMR= 1.5481829E+03 LAM2/BMR= 9.3340538E+02 (LAM1+LAM2)/BMR= 2.4815883E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 4.5989E-02 + 3.4492E-02 = 8.0480178E-02 (1/Gy) beta: 4.1888E-02 + 1.3144E-02 = 5.5032198E-02 (1/Gy^2) alpha/beta: 1.4624198 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (TSU cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 5.1190E-06 4.3000E-04 8.4000E+01 1.00587E+00 1.43E-01 9.99965E-01 -5.9050E-03 2 1.2015E-02 1.0092E+00 8.4000E+01 8.08286E-01 1.43E-01 8.72016E-01 7.3084E-02 3 2.3842E-02 2.0028E+00 8.4000E+01 6.65025E-01 1.43E-01 6.85755E-01 3.0230E-02 4 3.5555E-02 2.9866E+00 8.4000E+01 5.23411E-01 1.43E-01 4.89393E-01 -6.9511E-02 5 4.7589E-02 3.9975E+00 8.4000E+01 3.31045E-01 1.43E-01 3.13288E-01 -5.6679E-02 6 5.9411E-02 4.9905E+00 8.4000E+01 1.59990E-01 1.43E-01 1.83876E-01 1.2990E-01 7 7.1205E-02 5.9812E+00 8.4000E+01 1.02387E-01 1.43E-01 9.87315E-02 -3.7024E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-6.951E-02 max=1.299E-01, mean=9.1566E-03, stdev=7.3021E-02, var=5.3321E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.33177)= 7.6189E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93402)=6.039E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-2.627E-02 max=4.910E-02, mean=3.4609E-03, stdev=2.7599E-02, var=7.6173E-04 Student's T test (mean=0, NDF=3): Pr>ABS(0.33177)= 7.6189E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93402)=6.039E-01 (passed normality test) NOX=7, NPAR=3 CFE.SF: Cell survival data for TSU cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 5.1190E-06 4.3000E-04 8.4000E+01 -5.87000E-03 1.00587E+00 1.00E+01 2 2 1.2015E-02 1.0092E+00 8.4000E+01 1.91714E-01 8.08286E-01 1.00E+01 3 3 2.3842E-02 2.0028E+00 8.4000E+01 3.34975E-01 6.65025E-01 1.00E+01 4 4 3.5555E-02 2.9866E+00 8.4000E+01 4.76589E-01 5.23411E-01 1.00E+01 5 5 4.7589E-02 3.9975E+00 8.4000E+01 6.68955E-01 3.31045E-01 1.00E+01 6 6 5.9411E-02 4.9905E+00 8.4000E+01 8.40010E-01 1.59990E-01 1.00E+01 7 7 7.1205E-02 5.9812E+00 8.4000E+01 8.97613E-01 1.02387E-01 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (TSU). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 5.119E-06 1.200E+01 4.000E+02 4.3000E-04 -1.3611E+01 -5.8528E-03 2 2 1.201E-02 1.200E+01 4.000E+02 1.0092E+00 2.1089E-01 2.1284E-01 3 3 2.384E-02 1.200E+01 4.000E+02 2.0028E+00 2.0368E-01 4.0793E-01 4 4 3.555E-02 1.200E+01 4.000E+02 2.9866E+00 2.1677E-01 6.4739E-01 5 5 4.759E-02 1.200E+01 4.000E+02 3.9975E+00 2.7655E-01 1.1055E+00 6 6 5.941E-02 1.200E+01 4.000E+02 4.9905E+00 3.6722E-01 1.8326E+00 7 7 7.120E-02 1.200E+01 4.000E+02 5.9812E+00 3.8103E-01 2.2790E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 1.2417 VC 2.00I 15-JUL-2003 02-AUG-2003 02:30:25 PM