VC 2.00J 25-SEP-2003 20-NOV-2003 05:35:42 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: c:\kbem\bin\vc.exe c:\kbem\archive\human\prostate\ppc1\tlk\ppc1.inp FNI: C:\KBEM\archive\human\Prostate\ppc1\tlk\ppc1.inp FNO: C:\KBEM\archive\human\Prostate\ppc1\tlk\ppc1.out RADX: C:\KBEM\archive\human\Prostate\ppc1\tlk\ppc1.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 7.17785E-12 4.41151E-03 25.000000 Complex DSB = 2.87114E-13 1.76460E-04 1.000000 Total DSB = 7.46496E-12 4.58797E-03 26.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 5.333333E-03 (=0.533%) PHI2= 5.333333E-03 (=0.533%) (1-A1)*PHI1= 5.333333E-03 (=0.533%) (1-A2)*PHI2= 5.333333E-03 (=0.533%) (1-A1)*(1-PHI1)= 9.946667E-01 (=99.467%) (1-A2)*(1-PHI2)= 9.946667E-01 (=99.467%) RHT1= 8.633745 h (=518.02 minute) RHT2= 2.499567 h (=149.97 minute) LAM1= 8.0283488E-02 (1/h) LAM2= 2.7730685E-01 (1/h) BMR= 7.6195843E-05 (1/h) LAM1/BMR= 1.0536466E+03 LAM2/BMR= 3.6393960E+03 (LAM1+LAM2)/BMR= 4.6930426E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.3333E-01 + 5.3333E-03 = 1.3866666E-01 (1/Gy) beta: 7.3869E-02 + 1.3370E-03 = 7.5205756E-02 (1/Gy^2) alpha/beta: 1.8438304 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 1.460E-02 1.103E-03 1.5707E-02 9.844159E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 3.921E-02 2.684E-03 4.1891E-02 9.589747E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 8.697E-02 5.132E-03 9.2099E-02 9.120153E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 2.051E-01 9.400E-03 2.1453E-01 8.069221E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 3.491E-01 1.295E-02 3.6208E-01 6.962235E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 5.146E-01 1.591E-02 5.3049E-01 5.883176E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 8.959E-01 2.041E-02 9.1632E-01 3.999882E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 1.327E+00 2.353E-02 1.3504E+00 2.591252E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 1.792E+00 2.570E-02 1.8180E+00 1.623500E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 2.282E+00 2.720E-02 2.3087E+00 9.938801E-02 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 2.787E+00 2.824E-02 2.8155E+00 5.987437E-02 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 3.304E+00 2.896E-02 3.3334E+00 3.567070E-02 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 3.830E+00 2.946E-02 3.8591E+00 2.108765E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 4.360E+00 2.981E-02 4.3901E+00 1.239991E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 5.701E+00 3.028E-02 5.7314E+00 3.242457E-03 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 7.052E+00 3.047E-02 7.0826E+00 8.395511E-04 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 8.407E+00 3.054E-02 8.4378E+00 2.165229E-04 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 9.764E+00 3.057E-02 9.7946E+00 5.575359E-05 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 1.248E+01 3.059E-02 1.2510E+01 3.691042E-06 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 1.519E+01 3.059E-02 1.5225E+01 2.442353E-07 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 1.791E+01 3.059E-02 1.7941E+01 1.615969E-08 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 1.461E-02 1.121E-03 1.5733E-02 9.843904E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 3.933E-02 2.793E-03 4.2126E-02 9.587494E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 8.795E-02 5.551E-03 9.3504E-02 9.107346E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 2.126E-01 1.097E-02 2.2357E-01 7.996566E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 3.731E-01 1.626E-02 3.8934E-01 6.775063E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 5.685E-01 2.142E-02 5.8995E-01 5.543527E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 1.061E+00 3.139E-02 1.0925E+00 3.353662E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 1.684E+00 4.091E-02 1.7251E+00 1.781487E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 2.432E+00 5.002E-02 2.4820E+00 8.357593E-02 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 3.299E+00 5.872E-02 3.3577E+00 3.481446E-02 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 4.280E+00 6.706E-02 4.3472E+00 1.294244E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 5.371E+00 7.506E-02 5.4458E+00 4.314338E-03 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 6.566E+00 8.272E-02 6.6490E+00 1.295369E-03 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 7.862E+00 9.008E-02 7.9525E+00 3.517865E-04 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 1.152E+01 1.073E-01 1.1625E+01 8.939693E-06 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 1.572E+01 1.229E-01 1.5845E+01 1.314461E-07 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 2.043E+01 1.371E-01 2.0563E+01 1.174208E-09 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 2.559E+01 1.501E-01 2.5736E+01 6.650669E-12 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 3.713E+01 1.731E-01 3.7304E+01 6.293988E-17 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 5.010E+01 1.927E-01 5.0296E+01 1.434370E-22 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 6.430E+01 2.097E-01 6.4510E+01 9.627585E-29 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 4.017E+00 1.000E-01 2.500E-01 9.8442E-01 9.8442E-01 1.0000E+00 9.8442E-01 9.8442E-01 9.8550E-01 3 4.042E+00 2.500E-01 2.500E-01 9.5897E-01 9.5897E-01 1.0000E+00 9.5897E-01 9.5897E-01 9.6155E-01 4 4.083E+00 5.000E-01 2.500E-01 9.1202E-01 9.1202E-01 1.0000E+00 9.1202E-01 9.1202E-01 9.1671E-01 5 4.167E+00 1.000E+00 2.500E-01 8.0692E-01 8.0692E-01 1.0000E+00 8.0692E-01 8.0692E-01 8.1454E-01 6 4.250E+00 1.500E+00 2.500E-01 6.9622E-01 6.9622E-01 1.0000E+00 6.9622E-01 6.9622E-01 7.0530E-01 7 4.333E+00 2.000E+00 2.500E-01 5.8832E-01 5.8832E-01 1.0000E+00 5.8832E-01 5.8832E-01 5.9775E-01 8 4.500E+00 3.000E+00 2.500E-01 3.9999E-01 3.9999E-01 1.0000E+00 3.9999E-01 3.9999E-01 4.0824E-01 9 4.667E+00 4.000E+00 2.500E-01 2.5913E-01 2.5913E-01 1.0000E+00 2.5913E-01 2.5913E-01 2.6530E-01 10 4.833E+00 5.000E+00 2.500E-01 1.6235E-01 1.6235E-01 1.0000E+00 1.6235E-01 1.6235E-01 1.6658E-01 11 5.000E+00 6.000E+00 2.500E-01 9.9388E-02 9.9388E-02 1.0000E+00 9.9388E-02 9.9388E-02 1.0213E-01 12 5.167E+00 7.000E+00 2.500E-01 5.9874E-02 5.9874E-02 1.0000E+00 5.9874E-02 5.9874E-02 6.1589E-02 13 5.333E+00 8.000E+00 2.500E-01 3.5671E-02 3.5671E-02 1.0000E+00 3.5671E-02 3.5671E-02 3.6719E-02 14 5.500E+00 9.000E+00 2.500E-01 2.1088E-02 2.1088E-02 1.0000E+00 2.1088E-02 2.1088E-02 2.1718E-02 15 5.667E+00 1.000E+01 2.500E-01 1.2400E-02 1.2400E-02 1.0000E+00 1.2400E-02 1.2400E-02 1.2775E-02 16 6.083E+00 1.250E+01 2.500E-01 3.2425E-03 3.2425E-03 1.0000E+00 3.2425E-03 3.2425E-03 3.3421E-03 17 6.500E+00 1.500E+01 2.500E-01 8.3955E-04 8.3955E-04 1.0000E+00 8.3955E-04 8.3955E-04 8.6552E-04 18 6.917E+00 1.750E+01 2.500E-01 2.1652E-04 2.1652E-04 1.0000E+00 2.1652E-04 2.1652E-04 2.2324E-04 19 7.333E+00 2.000E+01 2.500E-01 5.5754E-05 5.5754E-05 1.0000E+00 5.5754E-05 5.5754E-05 5.7484E-05 20 8.167E+00 2.500E+01 2.500E-01 3.6910E-06 3.6910E-06 1.0000E+00 3.6910E-06 3.6910E-06 3.8057E-06 21 9.000E+00 3.000E+01 2.500E-01 2.4424E-07 2.4424E-07 1.0000E+00 2.4424E-07 2.4424E-07 2.5182E-07 22 9.833E+00 3.500E+01 2.500E-01 1.6160E-08 1.6160E-08 1.0000E+00 1.6160E-08 1.6160E-08 1.6662E-08 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 4.000E+00 1.000E-01 6.000E+01 9.8439E-01 9.8439E-01 1.0000E+00 9.8439E-01 9.8439E-01 9.8549E-01 25 4.000E+00 2.500E-01 6.000E+01 9.5875E-01 9.5875E-01 1.0000E+00 9.5875E-01 9.5875E-01 9.6143E-01 26 4.000E+00 5.000E-01 6.000E+01 9.1073E-01 9.1073E-01 1.0000E+00 9.1073E-01 9.1073E-01 9.1580E-01 27 4.001E+00 1.000E+00 6.000E+01 7.9966E-01 7.9966E-01 1.0000E+00 7.9966E-01 7.9966E-01 8.0848E-01 28 4.001E+00 1.500E+00 6.000E+01 6.7751E-01 6.7751E-01 1.0000E+00 6.7751E-01 6.7751E-01 6.8861E-01 29 4.001E+00 2.000E+00 6.000E+01 5.5435E-01 5.5435E-01 1.0000E+00 5.5435E-01 5.5435E-01 5.6636E-01 30 4.002E+00 3.000E+00 6.000E+01 3.3537E-01 3.3537E-01 1.0000E+00 3.3537E-01 3.3537E-01 3.4606E-01 31 4.003E+00 4.000E+00 6.000E+01 1.7815E-01 1.7815E-01 1.0000E+00 1.7815E-01 1.7815E-01 1.8559E-01 32 4.003E+00 5.000E+00 6.000E+01 8.3576E-02 8.3576E-02 1.0000E+00 8.3576E-02 8.3576E-02 8.7862E-02 33 4.004E+00 6.000E+00 6.000E+01 3.4814E-02 3.4814E-02 1.0000E+00 3.4814E-02 3.4814E-02 3.6920E-02 34 4.005E+00 7.000E+00 6.000E+01 1.2942E-02 1.2942E-02 1.0000E+00 1.2942E-02 1.2942E-02 1.3840E-02 35 4.006E+00 8.000E+00 6.000E+01 4.3143E-03 4.3143E-03 1.0000E+00 4.3143E-03 4.3143E-03 4.6506E-03 36 4.006E+00 9.000E+00 6.000E+01 1.2954E-03 1.2954E-03 1.0000E+00 1.2954E-03 1.2954E-03 1.4071E-03 37 4.007E+00 1.000E+01 6.000E+01 3.5179E-04 3.5179E-04 1.0000E+00 3.5179E-04 3.5179E-04 3.8495E-04 38 4.009E+00 1.250E+01 6.000E+01 8.9397E-06 8.9397E-06 1.0000E+00 8.9397E-06 8.9397E-06 9.9518E-06 39 4.010E+00 1.500E+01 6.000E+01 1.3145E-07 1.3145E-07 1.0000E+00 1.3145E-07 1.3145E-07 1.4863E-07 40 4.012E+00 1.750E+01 6.000E+01 1.1742E-09 1.1742E-09 1.0000E+00 1.1742E-09 1.1742E-09 1.3467E-09 41 4.014E+00 2.000E+01 6.000E+01 6.6507E-12 6.6507E-12 1.0000E+00 6.6507E-12 6.6507E-12 7.7278E-12 42 4.017E+00 2.500E+01 6.000E+01 6.2940E-17 6.2940E-17 1.0000E+00 6.2940E-17 6.2940E-17 7.4835E-17 43 4.021E+00 3.000E+01 6.000E+01 1.4344E-22 1.4344E-22 1.0000E+00 1.4344E-22 1.4344E-22 1.7393E-22 44 4.024E+00 3.500E+01 6.000E+01 9.6276E-29 9.6276E-29 1.0000E+00 9.6276E-29 9.6276E-29 1.1873E-28 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 2.500E-01 2.584E+00 0.00E+00 2.58429E+00 1.081E-05 1.081E-05 1.098E-05 3 2.500E-01 2.500E-01 6.458E+00 0.00E+00 6.45811E+00 2.632E-05 2.632E-05 2.745E-05 4 5.000E-01 2.500E-01 1.291E+01 0.00E+00 1.29079E+01 5.003E-05 5.003E-05 5.486E-05 5 1.000E+00 2.500E-01 2.579E+01 0.00E+00 2.57855E+01 8.842E-05 8.842E-05 1.096E-04 6 1.500E+00 2.500E-01 3.864E+01 0.00E+00 3.86379E+01 1.143E-04 1.143E-04 1.642E-04 7 2.000E+00 2.500E-01 5.147E+01 0.00E+00 5.14695E+01 1.287E-04 1.287E-04 2.187E-04 8 3.000E+00 2.500E-01 7.708E+01 0.00E+00 7.70837E+01 1.310E-04 1.310E-04 3.276E-04 9 4.000E+00 2.500E-01 1.026E+02 0.00E+00 1.02650E+02 1.130E-04 1.130E-04 4.362E-04 10 5.000E+00 2.500E-01 1.282E+02 0.00E+00 1.28182E+02 8.842E-05 8.842E-05 5.446E-04 11 6.000E+00 2.500E-01 1.537E+02 0.00E+00 1.53691E+02 6.490E-05 6.490E-05 6.530E-04 12 7.000E+00 2.500E-01 1.792E+02 0.00E+00 1.79184E+02 4.558E-05 4.558E-05 7.612E-04 13 8.000E+00 2.500E-01 2.047E+02 0.00E+00 2.04667E+02 3.101E-05 3.101E-05 8.695E-04 14 9.000E+00 2.500E-01 2.301E+02 0.00E+00 2.30141E+02 2.062E-05 2.062E-05 9.776E-04 15 1.000E+01 2.500E-01 2.556E+02 0.00E+00 2.55610E+02 1.346E-05 1.346E-05 1.086E-03 16 1.250E+01 2.500E-01 3.193E+02 0.00E+00 3.19269E+02 4.397E-06 4.397E-06 1.356E-03 17 1.500E+01 2.500E-01 3.829E+02 0.00E+00 3.82917E+02 1.365E-06 1.365E-06 1.626E-03 18 1.750E+01 2.500E-01 4.466E+02 0.00E+00 4.46562E+02 4.105E-07 4.105E-07 1.896E-03 19 2.000E+01 2.500E-01 5.102E+02 0.00E+00 5.10205E+02 1.208E-07 1.208E-07 2.166E-03 20 2.500E+01 2.500E-01 6.375E+02 0.00E+00 6.37490E+02 9.987E-09 9.987E-09 2.706E-03 21 3.000E+01 2.500E-01 7.648E+02 0.00E+00 7.64775E+02 7.925E-10 7.925E-10 3.245E-03 22 3.500E+01 2.500E-01 8.921E+02 0.00E+00 8.92059E+02 6.115E-11 6.115E-11 3.784E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.000E+01 2.584E+00 0.00E+00 2.58427E+00 1.081E-05 1.081E-05 1.098E-05 25 2.500E-01 6.000E+01 6.458E+00 0.00E+00 6.45787E+00 2.631E-05 2.631E-05 2.745E-05 26 5.000E-01 6.000E+01 1.291E+01 0.00E+00 1.29065E+01 4.995E-05 4.995E-05 5.485E-05 27 1.000E+00 6.000E+01 2.578E+01 0.00E+00 2.57764E+01 8.760E-05 8.760E-05 1.095E-04 28 1.500E+00 6.000E+01 3.861E+01 0.00E+00 3.86107E+01 1.112E-04 1.112E-04 1.641E-04 29 2.000E+00 6.000E+01 5.141E+01 0.00E+00 5.14100E+01 1.211E-04 1.211E-04 2.185E-04 30 3.000E+00 6.000E+01 7.691E+01 0.00E+00 7.69075E+01 1.096E-04 1.096E-04 3.268E-04 31 4.000E+00 6.000E+01 1.023E+02 0.00E+00 1.02275E+02 7.742E-05 7.742E-05 4.346E-04 32 5.000E+00 6.000E+01 1.275E+02 0.00E+00 1.27518E+02 4.528E-05 4.528E-05 5.418E-04 33 6.000E+00 6.000E+01 1.526E+02 0.00E+00 1.52642E+02 2.258E-05 2.258E-05 6.485E-04 34 7.000E+00 6.000E+01 1.777E+02 0.00E+00 1.77653E+02 9.768E-06 9.768E-06 7.547E-04 35 8.000E+00 6.000E+01 2.026E+02 0.00E+00 2.02554E+02 3.712E-06 3.712E-06 8.605E-04 36 9.000E+00 6.000E+01 2.274E+02 0.00E+00 2.27351E+02 1.251E-06 1.251E-06 9.658E-04 37 1.000E+01 6.000E+01 2.520E+02 0.00E+00 2.52048E+02 3.766E-07 3.766E-07 1.071E-03 38 1.250E+01 6.000E+01 3.134E+02 0.00E+00 3.13375E+02 1.190E-08 1.190E-08 1.331E-03 39 1.500E+01 6.000E+01 3.742E+02 0.00E+00 3.74155E+02 2.089E-10 2.089E-10 1.589E-03 40 1.750E+01 6.000E+01 4.344E+02 0.00E+00 4.34437E+02 2.166E-12 2.166E-12 1.845E-03 41 2.000E+01 6.000E+01 4.943E+02 0.00E+00 4.94264E+02 1.396E-14 1.396E-14 2.098E-03 42 2.500E+01 6.000E+01 6.127E+02 0.00E+00 6.12696E+02 1.637E-19 1.637E-19 2.601E-03 43 3.000E+01 6.000E+01 7.297E+02 0.00E+00 7.29704E+02 4.441E-25 4.441E-25 3.096E-03 44 3.500E+01 6.000E+01 8.455E+02 0.00E+00 8.45490E+02 3.453E-31 3.453E-31 3.587E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 2.500E-01 2.584E+00 1.081E-05 1.098E-05 6.8994E-05 6.9125E-05 6.8048E-05 3 2.500E-01 2.500E-01 6.458E+00 2.632E-05 2.745E-05 6.8993E-05 6.9321E-05 6.6477E-05 4 5.000E-01 2.500E-01 1.291E+01 5.003E-05 5.486E-05 6.8991E-05 6.9646E-05 6.3518E-05 5 1.000E+00 2.500E-01 2.579E+01 8.842E-05 1.096E-04 6.8988E-05 7.0295E-05 5.6722E-05 6 1.500E+00 2.500E-01 3.864E+01 1.143E-04 1.642E-04 6.8984E-05 7.0942E-05 4.9392E-05 7 2.000E+00 2.500E-01 5.147E+01 1.287E-04 2.187E-04 6.8980E-05 7.1589E-05 4.2117E-05 8 3.000E+00 2.500E-01 7.708E+01 1.310E-04 3.276E-04 6.8973E-05 7.2880E-05 2.9151E-05 9 4.000E+00 2.500E-01 1.026E+02 1.130E-04 4.362E-04 6.8965E-05 7.4168E-05 1.9219E-05 10 5.000E+00 2.500E-01 1.282E+02 8.842E-05 5.446E-04 6.8958E-05 7.5454E-05 1.2250E-05 11 6.000E+00 2.500E-01 1.537E+02 6.490E-05 6.530E-04 6.8950E-05 7.6739E-05 7.6269E-06 12 7.000E+00 2.500E-01 1.792E+02 4.558E-05 7.612E-04 6.8943E-05 7.8023E-05 4.6716E-06 13 8.000E+00 2.500E-01 2.047E+02 3.101E-05 8.695E-04 6.8935E-05 7.9306E-05 2.8289E-06 14 9.000E+00 2.500E-01 2.301E+02 2.062E-05 9.776E-04 6.8928E-05 8.0589E-05 1.6994E-06 15 1.000E+01 2.500E-01 2.556E+02 1.346E-05 1.086E-03 6.8920E-05 8.1871E-05 1.0152E-06 16 1.250E+01 2.500E-01 3.193E+02 4.397E-06 1.356E-03 6.8902E-05 8.5076E-05 2.7586E-07 17 1.500E+01 2.500E-01 3.829E+02 1.365E-06 1.626E-03 6.8883E-05 8.8279E-05 7.4115E-08 18 1.750E+01 2.500E-01 4.466E+02 4.105E-07 1.896E-03 6.8864E-05 9.1481E-05 1.9808E-08 19 2.000E+01 2.500E-01 5.102E+02 1.208E-07 2.166E-03 6.8846E-05 9.4683E-05 5.2789E-09 20 2.500E+01 2.500E-01 6.375E+02 9.987E-09 2.706E-03 6.8809E-05 1.0108E-04 3.7310E-10 21 3.000E+01 2.500E-01 7.648E+02 7.925E-10 3.245E-03 6.8771E-05 1.0748E-04 2.6250E-11 22 3.500E+01 2.500E-01 8.921E+02 6.115E-11 3.784E-03 6.8734E-05 1.1387E-04 1.8401E-12 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.000E+01 2.584E+00 1.081E-05 1.098E-05 6.8994E-05 6.9125E-05 6.8046E-05 25 2.500E-01 6.000E+01 6.458E+00 2.631E-05 2.745E-05 6.8993E-05 6.9321E-05 6.6461E-05 26 5.000E-01 6.000E+01 1.291E+01 4.995E-05 5.485E-05 6.8991E-05 6.9646E-05 6.3429E-05 27 1.000E+00 6.000E+01 2.578E+01 8.760E-05 1.095E-04 6.8988E-05 7.0294E-05 5.6211E-05 28 1.500E+00 6.000E+01 3.861E+01 1.112E-04 1.641E-04 6.8984E-05 7.0941E-05 4.8063E-05 29 2.000E+00 6.000E+01 5.141E+01 1.211E-04 2.185E-04 6.8980E-05 7.1586E-05 3.9684E-05 30 3.000E+00 6.000E+01 7.691E+01 1.096E-04 3.268E-04 6.8973E-05 7.2871E-05 2.4438E-05 31 4.000E+00 6.000E+01 1.023E+02 7.742E-05 4.346E-04 6.8965E-05 7.4149E-05 1.3210E-05 32 5.000E+00 6.000E+01 1.275E+02 4.528E-05 5.418E-04 6.8958E-05 7.5421E-05 6.3033E-06 33 6.000E+00 6.000E+01 1.526E+02 2.258E-05 6.485E-04 6.8950E-05 7.6686E-05 2.6698E-06 34 7.000E+00 6.000E+01 1.777E+02 9.768E-06 7.547E-04 6.8943E-05 7.7946E-05 1.0088E-06 35 8.000E+00 6.000E+01 2.026E+02 3.712E-06 8.605E-04 6.8936E-05 7.9200E-05 3.4170E-07 36 9.000E+00 6.000E+01 2.274E+02 1.251E-06 9.658E-04 6.8929E-05 8.0449E-05 1.0421E-07 37 1.000E+01 6.000E+01 2.520E+02 3.766E-07 1.071E-03 6.8921E-05 8.1692E-05 2.8738E-08 38 1.250E+01 6.000E+01 3.134E+02 1.190E-08 1.331E-03 6.8903E-05 8.4779E-05 7.5790E-10 39 1.500E+01 6.000E+01 3.742E+02 2.089E-10 1.589E-03 6.8886E-05 8.7838E-05 1.1546E-11 40 1.750E+01 6.000E+01 4.344E+02 2.166E-12 1.845E-03 6.8868E-05 9.0872E-05 1.0670E-13 41 2.000E+01 6.000E+01 4.943E+02 1.396E-14 2.098E-03 6.8850E-05 9.3881E-05 6.2437E-16 42 2.500E+01 6.000E+01 6.127E+02 1.637E-19 2.601E-03 6.8816E-05 9.9836E-05 6.2837E-21 43 3.000E+01 6.000E+01 7.297E+02 4.441E-25 3.096E-03 6.8782E-05 1.0572E-04 1.5164E-26 44 3.500E+01 6.000E+01 8.455E+02 3.453E-31 3.587E-03 6.8748E-05 1.1153E-04 1.0738E-32 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.1387 (1/Gy), alpha/beta = 1.8438 (Gy), lamda1 = 8.028E-02 (1/h), lamda2 = 2.773E-01 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 9.894E-01 9.640E-01 2.447E+00 9.8550E-01 9.844159E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 9.738E-01 9.136E-01 1.537E+00 9.6152E-01 9.589747E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 9.486E-01 8.382E-01 1.211E+00 9.1656E-01 9.120153E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 9.010E-01 7.137E-01 1.009E+00 8.1369E-01 8.069221E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 8.570E-01 6.164E-01 9.106E-01 7.0307E-01 6.962235E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 8.163E-01 5.394E-01 8.415E-01 5.9368E-01 5.883176E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 7.434E-01 4.269E-01 7.392E-01 4.0037E-01 3.999882E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 6.804E-01 3.504E-01 6.613E-01 2.5505E-01 2.591252E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 6.256E-01 2.958E-01 5.982E-01 1.5591E-01 1.623500E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 5.777E-01 2.554E-01 5.454E-01 9.2494E-02 9.938801E-02 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 5.357E-01 2.244E-01 5.006E-01 5.3695E-02 5.987437E-02 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 4.987E-01 2.000E-01 4.621E-01 3.0684E-02 3.567070E-02 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 4.659E-01 1.803E-01 4.286E-01 1.7336E-02 2.108765E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 4.367E-01 1.641E-01 3.994E-01 9.7133E-03 1.239991E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 3.764E-01 1.338E-01 3.402E-01 2.2312E-03 3.242457E-03 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 3.297E-01 1.130E-01 2.956E-01 5.0359E-04 8.395511E-04 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 2.928E-01 9.772E-02 2.610E-01 1.1277E-04 2.165229E-04 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 2.630E-01 8.609E-02 2.334E-01 2.5164E-05 5.575359E-05 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 2.181E-01 6.952E-02 1.924E-01 1.2481E-06 3.691042E-06 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 1.861E-01 5.830E-02 1.635E-01 6.1813E-08 2.442353E-07 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 1.621E-01 5.019E-02 1.421E-01 3.0604E-09 1.615969E-08 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 1.000E+00 9.998E-01 2.481E+00 9.8549E-01 9.843904E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 9.999E-01 9.996E-01 1.587E+00 9.6140E-01 9.587494E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.998E-01 9.992E-01 1.286E+00 9.1564E-01 9.107346E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 9.996E-01 9.985E-01 1.129E+00 8.0748E-01 7.996566E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 9.993E-01 9.977E-01 1.072E+00 6.8585E-01 6.775063E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.991E-01 9.969E-01 1.039E+00 5.6109E-01 5.543527E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 9.987E-01 9.954E-01 9.995E-01 3.3558E-01 3.353662E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 9.982E-01 9.939E-01 9.727E-01 1.7278E-01 1.781487E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 9.978E-01 9.923E-01 9.513E-01 7.6604E-02 8.357593E-02 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 9.973E-01 9.908E-01 9.329E-01 2.9250E-02 3.481446E-02 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 9.969E-01 9.893E-01 9.163E-01 9.6213E-03 1.294244E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 9.964E-01 9.878E-01 9.010E-01 2.7268E-03 4.314338E-03 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 9.960E-01 9.863E-01 8.866E-01 6.6599E-04 1.295369E-03 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 9.956E-01 9.848E-01 8.730E-01 1.4021E-04 3.517865E-04 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 9.944E-01 9.810E-01 8.418E-01 1.4908E-06 8.939693E-06 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 9.933E-01 9.773E-01 8.135E-01 6.2930E-09 1.314461E-07 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 9.922E-01 9.736E-01 7.874E-01 1.0580E-11 1.174208E-09 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 9.911E-01 9.699E-01 7.633E-01 7.1069E-15 6.650669E-12 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 9.889E-01 9.626E-01 7.199E-01 2.0718E-22 6.293988E-17 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 9.868E-01 9.553E-01 6.816E-01 1.5990E-31 1.434370E-22 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 9.846E-01 9.482E-01 6.476E-01 3.3510E-42 9.627585E-29 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 4.017E+00 1.000E-01 9.8442E-01 9.8442E-01 9.8550E-01 3.7366E-01 3.7366E-01 3.7325E-01 3.7325E-01 3 4.042E+00 2.500E-01 9.5897E-01 9.5897E-01 9.6155E-01 3.8329E-01 3.8329E-01 3.8230E-01 3.8230E-01 4 4.083E+00 5.000E-01 9.1202E-01 9.1202E-01 9.1671E-01 4.0171E-01 4.0171E-01 3.9983E-01 3.9983E-01 5 4.167E+00 1.000E+00 8.0692E-01 8.0692E-01 8.1454E-01 4.4623E-01 4.4623E-01 4.4284E-01 4.4284E-01 6 4.250E+00 1.500E+00 6.9622E-01 6.9622E-01 7.0530E-01 4.9846E-01 4.9846E-01 4.9396E-01 4.9396E-01 7 4.333E+00 2.000E+00 5.8832E-01 5.8832E-01 5.9775E-01 5.5526E-01 5.5526E-01 5.5005E-01 5.5005E-01 8 4.500E+00 3.000E+00 3.9999E-01 3.9999E-01 4.0824E-01 6.7033E-01 6.7033E-01 6.6482E-01 6.6482E-01 9 4.667E+00 4.000E+00 2.5913E-01 2.5913E-01 2.6530E-01 7.7173E-01 7.7173E-01 7.6698E-01 7.6698E-01 10 4.833E+00 5.000E+00 1.6235E-01 1.6235E-01 1.6658E-01 8.5014E-01 8.5014E-01 8.4656E-01 8.4656E-01 11 5.000E+00 6.000E+00 9.9388E-02 9.9388E-02 1.0213E-01 9.0539E-01 9.0539E-01 9.0291E-01 9.0291E-01 12 5.167E+00 7.000E+00 5.9874E-02 5.9874E-02 6.1589E-02 9.4188E-01 9.4188E-01 9.4027E-01 9.4027E-01 13 5.333E+00 8.000E+00 3.5671E-02 3.5671E-02 3.6719E-02 9.6496E-01 9.6496E-01 9.6395E-01 9.6395E-01 14 5.500E+00 9.000E+00 2.1088E-02 2.1088E-02 2.1718E-02 9.7913E-01 9.7913E-01 9.7852E-01 9.7852E-01 15 5.667E+00 1.000E+01 1.2400E-02 1.2400E-02 1.2775E-02 9.8768E-01 9.8768E-01 9.8731E-01 9.8731E-01 16 6.083E+00 1.250E+01 3.2425E-03 3.2425E-03 3.3421E-03 9.9676E-01 9.9676E-01 9.9666E-01 9.9666E-01 17 6.500E+00 1.500E+01 8.3955E-04 8.3955E-04 8.6552E-04 9.9916E-01 9.9916E-01 9.9913E-01 9.9913E-01 18 6.917E+00 1.750E+01 2.1652E-04 2.1652E-04 2.2324E-04 9.9978E-01 9.9978E-01 9.9978E-01 9.9978E-01 19 7.333E+00 2.000E+01 5.5754E-05 5.5754E-05 5.7484E-05 9.9994E-01 9.9994E-01 9.9994E-01 9.9994E-01 20 8.167E+00 2.500E+01 3.6910E-06 3.6910E-06 3.8057E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 9.000E+00 3.000E+01 2.4424E-07 2.4424E-07 2.5182E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 9.833E+00 3.500E+01 1.6160E-08 1.6160E-08 1.6662E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 4.000E+00 1.000E-01 9.8439E-01 9.8439E-01 9.8549E-01 3.7367E-01 3.7367E-01 3.7325E-01 3.7325E-01 25 4.000E+00 2.500E-01 9.5875E-01 9.5875E-01 9.6143E-01 3.8337E-01 3.8337E-01 3.8235E-01 3.8235E-01 26 4.000E+00 5.000E-01 9.1073E-01 9.1073E-01 9.1580E-01 4.0223E-01 4.0223E-01 4.0019E-01 4.0019E-01 27 4.001E+00 1.000E+00 7.9966E-01 7.9966E-01 8.0848E-01 4.4948E-01 4.4948E-01 4.4554E-01 4.4554E-01 28 4.001E+00 1.500E+00 6.7751E-01 6.7751E-01 6.8861E-01 5.0788E-01 5.0788E-01 5.0227E-01 5.0227E-01 29 4.001E+00 2.000E+00 5.5435E-01 5.5435E-01 5.6636E-01 5.7444E-01 5.7444E-01 5.6759E-01 5.6759E-01 30 4.002E+00 3.000E+00 3.3537E-01 3.3537E-01 3.4606E-01 7.1508E-01 7.1508E-01 7.0747E-01 7.0747E-01 31 4.003E+00 4.000E+00 1.7815E-01 1.7815E-01 1.8559E-01 8.3682E-01 8.3682E-01 8.3062E-01 8.3062E-01 32 4.003E+00 5.000E+00 8.3576E-02 8.3576E-02 8.7862E-02 9.1982E-01 9.1982E-01 9.1589E-01 9.1589E-01 33 4.004E+00 6.000E+00 3.4814E-02 3.4814E-02 3.6920E-02 9.6578E-01 9.6578E-01 9.6375E-01 9.6375E-01 34 4.005E+00 7.000E+00 1.2942E-02 1.2942E-02 1.3840E-02 9.8714E-01 9.8714E-01 9.8626E-01 9.8626E-01 35 4.006E+00 8.000E+00 4.3143E-03 4.3143E-03 4.6506E-03 9.9569E-01 9.9569E-01 9.9536E-01 9.9536E-01 36 4.006E+00 9.000E+00 1.2954E-03 1.2954E-03 1.4071E-03 9.9871E-01 9.9871E-01 9.9859E-01 9.9859E-01 37 4.007E+00 1.000E+01 3.5179E-04 3.5179E-04 3.8495E-04 9.9965E-01 9.9965E-01 9.9962E-01 9.9962E-01 38 4.009E+00 1.250E+01 8.9397E-06 8.9397E-06 9.9518E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 39 4.010E+00 1.500E+01 1.3145E-07 1.3145E-07 1.4863E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 40 4.012E+00 1.750E+01 1.1742E-09 1.1742E-09 1.3467E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 4.014E+00 2.000E+01 6.6507E-12 6.6507E-12 7.7278E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 4.017E+00 2.500E+01 6.2940E-17 6.2940E-17 7.4835E-17 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.021E+00 3.000E+01 1.4344E-22 1.4344E-22 1.7393E-22 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.024E+00 3.500E+01 9.6276E-29 9.6276E-29 1.1873E-28 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 4.000E-01 1.667E-02 0.0000E+00 1.0000E-01 0.0000E+00 2.5000E-01 3 1.000E+00 4.167E-02 0.0000E+00 2.5000E-01 0.0000E+00 2.5000E-01 4 2.000E+00 8.333E-02 0.0000E+00 5.0000E-01 0.0000E+00 2.5000E-01 5 4.000E+00 1.667E-01 0.0000E+00 1.0000E+00 0.0000E+00 2.5000E-01 6 6.000E+00 2.500E-01 0.0000E+00 1.5000E+00 0.0000E+00 2.5000E-01 7 8.000E+00 3.333E-01 0.0000E+00 2.0000E+00 0.0000E+00 2.5000E-01 8 1.200E+01 5.000E-01 0.0000E+00 3.0000E+00 0.0000E+00 2.5000E-01 9 1.600E+01 6.667E-01 0.0000E+00 4.0000E+00 0.0000E+00 2.5000E-01 10 2.000E+01 8.333E-01 0.0000E+00 5.0000E+00 0.0000E+00 2.5000E-01 11 2.400E+01 1.000E+00 0.0000E+00 6.0000E+00 0.0000E+00 2.5000E-01 12 2.800E+01 1.167E+00 0.0000E+00 7.0000E+00 0.0000E+00 2.5000E-01 13 3.200E+01 1.333E+00 0.0000E+00 8.0000E+00 0.0000E+00 2.5000E-01 14 3.600E+01 1.500E+00 0.0000E+00 9.0000E+00 0.0000E+00 2.5000E-01 15 4.000E+01 1.667E+00 0.0000E+00 1.0000E+01 0.0000E+00 2.5000E-01 16 5.000E+01 2.083E+00 0.0000E+00 1.2500E+01 0.0000E+00 2.5000E-01 17 6.000E+01 2.500E+00 0.0000E+00 1.5000E+01 0.0000E+00 2.5000E-01 18 7.000E+01 2.917E+00 0.0000E+00 1.7500E+01 0.0000E+00 2.5000E-01 19 8.000E+01 3.333E+00 0.0000E+00 2.0000E+01 0.0000E+00 2.5000E-01 20 1.000E+02 4.167E+00 0.0000E+00 2.5000E+01 0.0000E+00 2.5000E-01 21 1.200E+02 5.000E+00 0.0000E+00 3.0000E+01 0.0000E+00 2.5000E-01 22 1.400E+02 5.833E+00 0.0000E+00 3.5000E+01 0.0000E+00 2.5000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.667E-03 6.944E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E+01 25 4.167E-03 1.736E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E+01 26 8.333E-03 3.472E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E+01 27 1.667E-02 6.944E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E+01 28 2.500E-02 1.042E-03 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E+01 29 3.333E-02 1.389E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E+01 30 5.000E-02 2.083E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E+01 31 6.667E-02 2.778E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E+01 32 8.333E-02 3.472E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E+01 33 1.000E-01 4.167E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E+01 34 1.167E-01 4.861E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E+01 35 1.333E-01 5.556E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E+01 36 1.500E-01 6.250E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E+01 37 1.667E-01 6.944E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E+01 38 2.083E-01 8.681E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E+01 39 2.500E-01 1.042E-02 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E+01 40 2.917E-01 1.215E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E+01 41 3.333E-01 1.389E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E+01 42 4.167E-01 1.736E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E+01 43 5.000E-01 2.083E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E+01 44 5.833E-01 2.431E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 9.15000E-03 VC 2.00J 25-SEP-2003 20-NOV-2003 05:35:43 PM