VC 2.00J 25-SEP-2003 20-NOV-2003 10:33:38 AM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: c:\kbem\bin\vc.exe c:\kbem\archive\human\prostate\ppc1\lpl\ppc1.inp FNI: C:\KBEM\archive\human\Prostate\ppc1\lpl\ppc1.inp FNO: C:\KBEM\archive\human\Prostate\ppc1\lpl\ppc1.out RADX: C:\KBEM\archive\human\Prostate\ppc1\lpl\ppc1.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- LPLM TABLE: Summary of LPL parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 RADIATION DAMAGE: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 8.61342E-12 5.29381E-03 30.000000 FL = 3.13692E-14 1.92795E-05 0.109257 DAMAGE REPAIR/MISREPAIR: A0= 9.500000E-01 (=95.000%) (1-A0)= 5.000000E-02 (=5.000%) RHT= 9.098287 h (=545.90 minute) LAM= 7.6184360E-02 (1/h) BMR= 5.1941386E-05 (1/h) LAM/BMR= 1.4667371E+03 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 0.109257 (1/Gy) beta = 0.076701 (1/Gy^2) alpha/beta = 1.424455 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 7.582E-04 1.289E-02 1.3649E-02 9.864439E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 4.659E-03 3.210E-02 3.6761E-02 9.639067E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 1.812E-02 6.381E-02 8.1925E-02 9.213411E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 6.858E-02 1.262E-01 1.9474E-01 8.230468E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 1.463E-01 1.873E-01 3.3356E-01 7.163712E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 2.469E-01 2.474E-01 4.9425E-01 6.100267E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 5.029E-01 3.651E-01 8.6799E-01 4.197954E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 8.139E-01 4.804E-01 1.2943E+00 2.740811E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 1.164E+00 5.939E-01 1.7580E+00 1.723940E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 1.542E+00 7.062E-01 2.2481E+00 1.056036E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 1.939E+00 8.176E-01 2.7569E+00 6.348756E-02 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 2.351E+00 9.284E-01 3.2791E+00 3.766346E-02 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 2.772E+00 1.039E+00 3.8107E+00 2.213364E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 3.200E+00 1.149E+00 4.3489E+00 1.292045E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 4.290E+00 1.423E+00 5.7125E+00 3.304279E-03 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 5.393E+00 1.697E+00 7.0894E+00 8.339175E-04 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 6.502E+00 1.970E+00 8.4718E+00 2.092813E-04 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 7.614E+00 2.243E+00 9.8567E+00 5.239668E-05 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 9.839E+00 2.789E+00 1.2629E+01 3.276330E-06 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 1.207E+01 3.336E+00 1.5402E+01 2.046890E-07 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 1.429E+01 3.882E+00 1.8175E+01 1.278597E-08 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 7.659E-04 1.292E-02 1.3686E-02 9.864068E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 4.777E-03 3.229E-02 3.7063E-02 9.636158E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 1.904E-02 6.452E-02 8.3561E-02 9.198351E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 7.564E-02 1.288E-01 2.0447E-01 8.150763E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 1.690E-01 1.930E-01 3.6197E-01 6.963021E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 2.984E-01 2.569E-01 5.5531E-01 5.738932E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 6.625E-01 3.842E-01 1.0467E+00 3.511104E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 1.162E+00 5.108E-01 1.6730E+00 1.876872E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 1.792E+00 6.367E-01 2.4291E+00 8.811846E-02 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 2.548E+00 7.620E-01 3.3100E+00 3.651549E-02 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 3.424E+00 8.867E-01 4.3112E+00 1.341794E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 4.417E+00 1.011E+00 5.4281E+00 4.391424E-03 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 5.522E+00 1.134E+00 6.6567E+00 1.285426E-03 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 6.735E+00 1.258E+00 7.9929E+00 3.378536E-04 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 1.022E+01 1.563E+00 1.1780E+01 7.653449E-06 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 1.430E+01 1.866E+00 1.6164E+01 9.551110E-08 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 1.893E+01 2.167E+00 2.1096E+01 6.885935E-10 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 2.407E+01 2.466E+00 2.6535E+01 2.991740E-12 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 3.573E+01 3.058E+00 3.8785E+01 1.431399E-17 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 4.901E+01 3.643E+00 5.2657E+01 1.353325E-23 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 6.372E+01 4.224E+00 6.7940E+01 3.118315E-30 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 4.017E+00 1.000E-01 2.500E-01 9.8644E-01 9.8644E-01 1.0000E+00 9.8644E-01 9.8644E-01 9.8838E-01 3 4.042E+00 2.500E-01 2.500E-01 9.6391E-01 9.6391E-01 1.0000E+00 9.6391E-01 9.6391E-01 9.6853E-01 4 4.083E+00 5.000E-01 2.500E-01 9.2134E-01 9.2134E-01 1.0000E+00 9.2134E-01 9.2134E-01 9.2984E-01 5 4.167E+00 1.000E+00 2.500E-01 8.2305E-01 8.2305E-01 1.0000E+00 8.2305E-01 8.2305E-01 8.3708E-01 6 4.250E+00 1.500E+00 2.500E-01 7.1637E-01 7.1637E-01 1.0000E+00 7.1637E-01 7.1637E-01 7.3334E-01 7 4.333E+00 2.000E+00 2.500E-01 6.1003E-01 6.1003E-01 1.0000E+00 6.1003E-01 6.1003E-01 6.2790E-01 8 4.500E+00 3.000E+00 2.500E-01 4.1980E-01 4.1980E-01 1.0000E+00 4.1980E-01 4.1980E-01 4.3578E-01 9 4.667E+00 4.000E+00 2.500E-01 2.7408E-01 2.7408E-01 1.0000E+00 2.7408E-01 2.7408E-01 2.8623E-01 10 4.833E+00 5.000E+00 2.500E-01 1.7239E-01 1.7239E-01 1.0000E+00 1.7239E-01 1.7239E-01 1.8081E-01 11 5.000E+00 6.000E+00 2.500E-01 1.0560E-01 1.0560E-01 1.0000E+00 1.0560E-01 1.0560E-01 1.1109E-01 12 5.167E+00 7.000E+00 2.500E-01 6.3488E-02 6.3488E-02 1.0000E+00 6.3488E-02 6.3488E-02 6.6930E-02 13 5.333E+00 8.000E+00 2.500E-01 3.7663E-02 3.7663E-02 1.0000E+00 3.7663E-02 3.7663E-02 3.9766E-02 14 5.500E+00 9.000E+00 2.500E-01 2.2134E-02 2.2134E-02 1.0000E+00 2.2134E-02 2.2134E-02 2.3395E-02 15 5.667E+00 1.000E+01 2.500E-01 1.2920E-02 1.2920E-02 1.0000E+00 1.2920E-02 1.2920E-02 1.3667E-02 16 6.083E+00 1.250E+01 2.500E-01 3.3043E-03 3.3043E-03 1.0000E+00 3.3043E-03 3.3043E-03 3.4990E-03 17 6.500E+00 1.500E+01 2.500E-01 8.3392E-04 8.3392E-04 1.0000E+00 8.3392E-04 8.3392E-04 8.8345E-04 18 6.917E+00 1.750E+01 2.500E-01 2.0928E-04 2.0928E-04 1.0000E+00 2.0928E-04 2.0928E-04 2.2176E-04 19 7.333E+00 2.000E+01 2.500E-01 5.2397E-05 5.2397E-05 1.0000E+00 5.2397E-05 5.2397E-05 5.5524E-05 20 8.167E+00 2.500E+01 2.500E-01 3.2763E-06 3.2763E-06 1.0000E+00 3.2763E-06 3.2763E-06 3.4721E-06 21 9.000E+00 3.000E+01 2.500E-01 2.0469E-07 2.0469E-07 1.0000E+00 2.0469E-07 2.0469E-07 2.1692E-07 22 9.833E+00 3.500E+01 2.500E-01 1.2786E-08 1.2786E-08 1.0000E+00 1.2786E-08 1.2786E-08 1.3550E-08 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 4.000E+00 1.000E-01 6.000E+01 9.8641E-01 9.8641E-01 1.0000E+00 9.8641E-01 9.8641E-01 9.8838E-01 25 4.000E+00 2.500E-01 6.000E+01 9.6362E-01 9.6362E-01 1.0000E+00 9.6362E-01 9.6362E-01 9.6842E-01 26 4.000E+00 5.000E-01 6.000E+01 9.1984E-01 9.1984E-01 1.0000E+00 9.1984E-01 9.1984E-01 9.2898E-01 27 4.001E+00 1.000E+00 6.000E+01 8.1508E-01 8.1508E-01 1.0000E+00 8.1508E-01 8.1508E-01 8.3119E-01 28 4.001E+00 1.500E+00 6.000E+01 6.9630E-01 6.9630E-01 1.0000E+00 6.9630E-01 6.9630E-01 7.1684E-01 29 4.001E+00 2.000E+00 6.000E+01 5.7389E-01 5.7389E-01 1.0000E+00 5.7389E-01 5.7389E-01 5.9634E-01 30 4.002E+00 3.000E+00 6.000E+01 3.5111E-01 3.5111E-01 1.0000E+00 3.5111E-01 3.5111E-01 3.7148E-01 31 4.003E+00 4.000E+00 6.000E+01 1.8769E-01 1.8769E-01 1.0000E+00 1.8769E-01 1.8769E-01 2.0205E-01 32 4.003E+00 5.000E+00 6.000E+01 8.8118E-02 8.8118E-02 1.0000E+00 8.8118E-02 8.8118E-02 9.6456E-02 33 4.004E+00 6.000E+00 6.000E+01 3.6515E-02 3.6515E-02 1.0000E+00 3.6515E-02 3.6515E-02 4.0617E-02 34 4.005E+00 7.000E+00 6.000E+01 1.3418E-02 1.3418E-02 1.0000E+00 1.3418E-02 1.3418E-02 1.5157E-02 35 4.006E+00 8.000E+00 6.000E+01 4.3914E-03 4.3914E-03 1.0000E+00 4.3914E-03 4.3914E-03 5.0351E-03 36 4.006E+00 9.000E+00 6.000E+01 1.2854E-03 1.2854E-03 1.0000E+00 1.2854E-03 1.2854E-03 1.4952E-03 37 4.007E+00 1.000E+01 6.000E+01 3.3785E-04 3.3785E-04 1.0000E+00 3.3785E-04 3.3785E-04 3.9846E-04 38 4.009E+00 1.250E+01 6.000E+01 7.6534E-06 7.6534E-06 1.0000E+00 7.6534E-06 7.6534E-06 9.3252E-06 39 4.010E+00 1.500E+01 6.000E+01 9.5511E-08 9.5511E-08 1.0000E+00 9.5511E-08 9.5511E-08 1.1991E-07 40 4.012E+00 1.750E+01 6.000E+01 6.8859E-10 6.8859E-10 1.0000E+00 6.8859E-10 6.8859E-10 8.8867E-10 41 4.014E+00 2.000E+01 6.000E+01 2.9917E-12 2.9917E-12 1.0000E+00 2.9917E-12 2.9917E-12 3.9607E-12 42 4.017E+00 2.500E+01 6.000E+01 1.4314E-17 1.4314E-17 1.0000E+00 1.4314E-17 1.4314E-17 1.9834E-17 43 4.021E+00 3.000E+01 6.000E+01 1.3533E-23 1.3533E-23 1.0000E+00 1.3533E-23 1.3533E-23 1.9507E-23 44 4.024E+00 3.500E+01 6.000E+01 3.1183E-30 3.1183E-30 1.0000E+00 3.1183E-30 3.1183E-30 4.6528E-30 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 2.500E-01 1.520E-01 0.00E+00 1.52025E-01 6.373E-07 6.373E-07 6.461E-07 3 2.500E-01 2.500E-01 3.878E-01 0.00E+00 3.87805E-01 1.589E-06 1.589E-06 1.648E-06 4 5.000E-01 2.500E-01 8.003E-01 0.00E+00 8.00269E-01 3.134E-06 3.134E-06 3.401E-06 5 1.000E+00 2.500E-01 1.691E+00 0.00E+00 1.69118E+00 5.916E-06 5.916E-06 7.188E-06 6 1.500E+00 2.500E-01 2.658E+00 0.00E+00 2.65838E+00 8.094E-06 8.094E-06 1.130E-05 7 2.000E+00 2.500E-01 3.690E+00 0.00E+00 3.68977E+00 9.566E-06 9.566E-06 1.568E-05 8 3.000E+00 2.500E-01 5.906E+00 0.00E+00 5.90613E+00 1.054E-05 1.054E-05 2.510E-05 9 4.000E+00 2.500E-01 8.277E+00 0.00E+00 8.27684E+00 9.641E-06 9.641E-06 3.518E-05 10 5.000E+00 2.500E-01 1.076E+01 0.00E+00 1.07570E+01 7.881E-06 7.881E-06 4.572E-05 11 6.000E+00 2.500E-01 1.331E+01 0.00E+00 1.33147E+01 5.976E-06 5.976E-06 5.659E-05 12 7.000E+00 2.500E-01 1.593E+01 0.00E+00 1.59274E+01 4.297E-06 4.297E-06 6.769E-05 13 8.000E+00 2.500E-01 1.858E+01 0.00E+00 1.85792E+01 2.974E-06 2.974E-06 7.896E-05 14 9.000E+00 2.500E-01 2.126E+01 0.00E+00 2.12587E+01 2.000E-06 2.000E-06 9.035E-05 15 1.000E+01 2.500E-01 2.396E+01 0.00E+00 2.39578E+01 1.315E-06 1.315E-06 1.018E-04 16 1.250E+01 2.500E-01 3.076E+01 0.00E+00 3.07580E+01 4.319E-07 4.319E-07 1.307E-04 17 1.500E+01 2.500E-01 3.760E+01 0.00E+00 3.75970E+01 1.332E-07 1.332E-07 1.598E-04 18 1.750E+01 2.500E-01 4.445E+01 0.00E+00 4.44525E+01 3.953E-08 3.953E-08 1.889E-04 19 2.000E+01 2.500E-01 5.132E+01 0.00E+00 5.13150E+01 1.143E-08 1.143E-08 2.181E-04 20 2.500E+01 2.500E-01 6.505E+01 0.00E+00 6.50472E+01 9.056E-10 9.056E-10 2.764E-04 21 3.000E+01 2.500E-01 7.878E+01 0.00E+00 7.87820E+01 6.852E-11 6.852E-11 3.348E-04 22 3.500E+01 2.500E-01 9.252E+01 0.00E+00 9.25172E+01 5.026E-12 5.026E-12 3.931E-04 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.000E+01 1.520E-01 0.00E+00 1.52045E-01 6.374E-07 6.374E-07 6.462E-07 25 2.500E-01 6.000E+01 3.881E-01 0.00E+00 3.88127E-01 1.590E-06 1.590E-06 1.650E-06 26 5.000E-01 6.000E+01 8.028E-01 0.00E+00 8.02822E-01 3.138E-06 3.138E-06 3.412E-06 27 1.000E+00 6.000E+01 1.711E+00 0.00E+00 1.71081E+00 5.926E-06 5.926E-06 7.271E-06 28 1.500E+00 6.000E+01 2.722E+00 0.00E+00 2.72180E+00 8.055E-06 8.055E-06 1.157E-05 29 2.000E+00 6.000E+01 3.834E+00 0.00E+00 3.83370E+00 9.350E-06 9.350E-06 1.629E-05 30 3.000E+00 6.000E+01 6.352E+00 0.00E+00 6.35213E+00 9.479E-06 9.479E-06 2.700E-05 31 4.000E+00 6.000E+01 9.251E+00 0.00E+00 9.25052E+00 7.379E-06 7.379E-06 3.931E-05 32 5.000E+00 6.000E+01 1.251E+01 0.00E+00 1.25142E+01 4.686E-06 4.686E-06 5.318E-05 33 6.000E+00 6.000E+01 1.613E+01 0.00E+00 1.61292E+01 2.503E-06 2.503E-06 6.855E-05 34 7.000E+00 6.000E+01 2.008E+01 0.00E+00 2.00824E+01 1.145E-06 1.145E-06 8.535E-05 35 8.000E+00 6.000E+01 2.436E+01 0.00E+00 2.43615E+01 4.546E-07 4.546E-07 1.035E-04 36 9.000E+00 6.000E+01 2.895E+01 0.00E+00 2.89546E+01 1.582E-07 1.582E-07 1.230E-04 37 1.000E+01 6.000E+01 3.385E+01 0.00E+00 3.38507E+01 4.860E-08 4.860E-08 1.439E-04 38 1.250E+01 6.000E+01 4.735E+01 0.00E+00 4.73479E+01 1.540E-09 1.540E-09 2.012E-04 39 1.500E+01 6.000E+01 6.252E+01 0.00E+00 6.25221E+01 2.538E-11 2.538E-11 2.657E-04 40 1.750E+01 6.000E+01 7.924E+01 0.00E+00 7.92393E+01 2.319E-13 2.319E-13 3.367E-04 41 2.000E+01 6.000E+01 9.738E+01 0.00E+00 9.73805E+01 1.238E-15 1.238E-15 4.138E-04 42 2.500E+01 6.000E+01 1.375E+02 0.00E+00 1.37521E+02 8.364E-21 8.364E-21 5.843E-04 43 3.000E+01 6.000E+01 1.822E+02 0.00E+00 1.82220E+02 1.048E-26 1.048E-26 7.741E-04 44 3.500E+01 6.000E+01 2.309E+02 0.00E+00 2.30885E+02 3.058E-33 3.058E-33 9.808E-04 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 2.500E-01 1.520E-01 6.373E-07 6.461E-07 6.8995E-05 6.9003E-05 6.8067E-05 3 2.500E-01 2.500E-01 3.878E-01 1.589E-06 1.648E-06 6.8995E-05 6.9015E-05 6.6524E-05 4 5.000E-01 2.500E-01 8.003E-01 3.134E-06 3.401E-06 6.8995E-05 6.9036E-05 6.3605E-05 5 1.000E+00 2.500E-01 1.691E+00 5.916E-06 7.188E-06 6.8995E-05 6.9080E-05 5.6856E-05 6 1.500E+00 2.500E-01 2.658E+00 8.094E-06 1.130E-05 6.8994E-05 6.9129E-05 4.9522E-05 7 2.000E+00 2.500E-01 3.690E+00 9.566E-06 1.568E-05 6.8994E-05 6.9181E-05 4.2202E-05 8 3.000E+00 2.500E-01 5.906E+00 1.054E-05 2.510E-05 6.8993E-05 6.9293E-05 2.9089E-05 9 4.000E+00 2.500E-01 8.277E+00 9.641E-06 3.518E-05 6.8993E-05 6.9412E-05 1.9025E-05 10 5.000E+00 2.500E-01 1.076E+01 7.881E-06 4.572E-05 6.8992E-05 6.9537E-05 1.1988E-05 11 6.000E+00 2.500E-01 1.331E+01 5.976E-06 5.659E-05 6.8991E-05 6.9666E-05 7.3570E-06 12 7.000E+00 2.500E-01 1.593E+01 4.297E-06 6.769E-05 6.8991E-05 6.9798E-05 4.4313E-06 13 8.000E+00 2.500E-01 1.858E+01 2.974E-06 7.896E-05 6.8990E-05 6.9932E-05 2.6339E-06 14 9.000E+00 2.500E-01 2.126E+01 2.000E-06 9.035E-05 6.8989E-05 7.0067E-05 1.5508E-06 15 1.000E+01 2.500E-01 2.396E+01 1.315E-06 1.018E-04 6.8988E-05 7.0203E-05 9.0705E-07 16 1.250E+01 2.500E-01 3.076E+01 4.319E-07 1.307E-04 6.8986E-05 7.0545E-05 2.3310E-07 17 1.500E+01 2.500E-01 3.760E+01 1.332E-07 1.598E-04 6.8984E-05 7.0890E-05 5.9116E-08 18 1.750E+01 2.500E-01 4.445E+01 3.953E-08 1.889E-04 6.8982E-05 7.1236E-05 1.4908E-08 19 2.000E+01 2.500E-01 5.132E+01 1.143E-08 2.181E-04 6.8980E-05 7.1581E-05 3.7506E-09 20 2.500E+01 2.500E-01 6.505E+01 9.056E-10 2.764E-04 6.8976E-05 7.2273E-05 2.3679E-10 21 3.000E+01 2.500E-01 7.878E+01 6.852E-11 3.348E-04 6.8972E-05 7.2965E-05 1.4935E-11 22 3.500E+01 2.500E-01 9.252E+01 5.026E-12 3.931E-04 6.8968E-05 7.3657E-05 9.4178E-13 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.000E+01 1.520E-01 6.374E-07 6.462E-07 6.8995E-05 6.9003E-05 6.8065E-05 25 2.500E-01 6.000E+01 3.881E-01 1.590E-06 1.650E-06 6.8995E-05 6.9015E-05 6.6504E-05 26 5.000E-01 6.000E+01 8.028E-01 3.138E-06 3.412E-06 6.8995E-05 6.9036E-05 6.3501E-05 27 1.000E+00 6.000E+01 1.711E+00 5.926E-06 7.271E-06 6.8995E-05 6.9081E-05 5.6307E-05 28 1.500E+00 6.000E+01 2.722E+00 8.055E-06 1.157E-05 6.8994E-05 6.9132E-05 4.8137E-05 29 2.000E+00 6.000E+01 3.834E+00 9.350E-06 1.629E-05 6.8994E-05 6.9188E-05 3.9707E-05 30 3.000E+00 6.000E+01 6.352E+00 9.479E-06 2.700E-05 6.8993E-05 6.9315E-05 2.4337E-05 31 4.000E+00 6.000E+01 9.251E+00 7.379E-06 3.931E-05 6.8993E-05 6.9461E-05 1.3037E-05 32 5.000E+00 6.000E+01 1.251E+01 4.686E-06 5.318E-05 6.8992E-05 6.9626E-05 6.1353E-06 33 6.000E+00 6.000E+01 1.613E+01 2.503E-06 6.855E-05 6.8990E-05 6.9808E-05 2.5491E-06 34 7.000E+00 6.000E+01 2.008E+01 1.145E-06 8.535E-05 6.8989E-05 7.0007E-05 9.3935E-07 35 8.000E+00 6.000E+01 2.436E+01 4.546E-07 1.035E-04 6.8988E-05 7.0223E-05 3.0838E-07 36 9.000E+00 6.000E+01 2.895E+01 1.582E-07 1.230E-04 6.8987E-05 7.0455E-05 9.0564E-08 37 1.000E+01 6.000E+01 3.385E+01 4.860E-08 1.439E-04 6.8985E-05 7.0701E-05 2.3887E-08 38 1.250E+01 6.000E+01 4.735E+01 1.540E-09 2.012E-04 6.8981E-05 7.1381E-05 5.4631E-10 39 1.500E+01 6.000E+01 6.252E+01 2.538E-11 2.657E-04 6.8977E-05 7.2146E-05 6.8907E-12 40 1.750E+01 6.000E+01 7.924E+01 2.319E-13 3.367E-04 6.8972E-05 7.2988E-05 5.0259E-14 41 2.000E+01 6.000E+01 9.738E+01 1.238E-15 4.138E-04 6.8967E-05 7.3902E-05 2.2110E-16 42 2.500E+01 6.000E+01 1.375E+02 8.364E-21 5.843E-04 6.8955E-05 7.5925E-05 1.0868E-21 43 3.000E+01 6.000E+01 1.822E+02 1.048E-26 7.741E-04 6.8942E-05 7.8176E-05 1.0580E-27 44 3.500E+01 6.000E+01 2.309E+02 3.058E-33 9.808E-04 6.8928E-05 8.0627E-05 2.5142E-34 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency LPLM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.109 (1/Gy), alpha/beta = 1.424 (Gy), lamda = 7.618E-02 (1/h). ====================================================================================================== --- Duration (h) --- Dose Dose Rate* ***** G FACTOR ***** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL GEFF SF1 SF2 ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 9.899E-01 3.550E+00 9.8838E-01 9.864439E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 9.751E-01 1.971E+00 9.6852E-01 9.639067E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 9.511E-01 1.424E+00 9.2973E-01 9.213411E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 9.057E-01 1.115E+00 8.3634E-01 8.230468E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 8.636E-01 9.832E-01 7.3131E-01 7.163712E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 8.244E-01 8.987E-01 6.2411E-01 6.100267E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 7.539E-01 7.826E-01 4.2819E-01 4.197954E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 6.925E-01 6.986E-01 2.7612E-01 2.740811E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 6.389E-01 6.319E-01 1.7011E-01 1.723940E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 5.917E-01 5.767E-01 1.0133E-01 1.056036E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 5.501E-01 5.301E-01 5.8875E-02 6.348756E-02 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 5.133E-01 4.899E-01 3.3588E-02 3.766346E-02 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 4.805E-01 4.551E-01 1.8905E-02 2.213364E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 4.512E-01 4.246E-01 1.0535E-02 1.292045E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 3.903E-01 3.627E-01 2.3749E-03 3.304279E-03 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 3.428E-01 3.158E-01 5.2353E-04 8.339175E-04 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 3.050E-01 2.793E-01 1.1422E-04 2.092813E-04 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 2.744E-01 2.500E-01 2.4797E-05 5.239668E-05 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 2.281E-01 2.065E-01 1.1623E-06 3.276330E-06 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 1.948E-01 1.756E-01 5.4357E-08 2.046890E-07 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 1.699E-01 1.527E-01 2.5408E-09 1.278597E-08 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 1.000E+00 3.599E+00 9.8838E-01 9.864068E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 9.999E-01 2.034E+00 9.6840E-01 9.636158E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.998E-01 1.509E+00 9.2886E-01 9.198351E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 9.996E-01 1.241E+00 8.3034E-01 8.150763E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 9.994E-01 1.148E+00 7.1437E-01 6.963021E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.992E-01 1.098E+00 5.9152E-01 5.738932E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 9.987E-01 1.041E+00 3.6160E-01 3.511104E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 9.983E-01 1.007E+00 1.8973E-01 1.876872E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 9.979E-01 9.819E-01 8.5456E-02 8.811846E-02 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 9.975E-01 9.613E-01 3.3049E-02 3.651549E-02 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 9.970E-01 9.436E-01 1.0976E-02 1.341794E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 9.966E-01 9.277E-01 3.1312E-03 4.391424E-03 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 9.962E-01 9.132E-01 7.6741E-04 1.285426E-03 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 9.958E-01 8.996E-01 1.6161E-04 3.378536E-04 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 9.947E-01 8.690E-01 1.6963E-06 7.653449E-06 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 9.937E-01 8.417E-01 6.9293E-09 9.551110E-08 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 9.926E-01 8.167E-01 1.1050E-11 6.885935E-10 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 9.916E-01 7.937E-01 6.8989E-15 2.991740E-12 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 9.895E-01 7.521E-01 1.6334E-22 1.431399E-17 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 9.874E-01 7.153E-01 9.4165E-32 1.353325E-23 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 9.853E-01 6.824E-01 1.3533E-42 3.118315E-30 ------------------------------------------------------------------------------------------------------ GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/D)/(beta*D). In the formula for GEFF, SF is surviving fraction as computed using the LPL model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL. The SF estimates are: SF1=EXP{-dose*[alpha+gl*beta*dose]} and SF2=EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 4.017E+00 1.000E-01 9.8644E-01 9.8644E-01 9.8838E-01 3.7290E-01 3.7290E-01 3.7218E-01 3.7218E-01 3 4.042E+00 2.500E-01 9.6391E-01 9.6391E-01 9.6853E-01 3.8140E-01 3.8140E-01 3.7964E-01 3.7964E-01 4 4.083E+00 5.000E-01 9.2134E-01 9.2134E-01 9.2984E-01 3.9798E-01 3.9798E-01 3.9462E-01 3.9462E-01 5 4.167E+00 1.000E+00 8.2305E-01 8.2305E-01 8.3708E-01 4.3909E-01 4.3909E-01 4.3297E-01 4.3297E-01 6 4.250E+00 1.500E+00 7.1637E-01 7.1637E-01 7.3334E-01 4.8852E-01 4.8852E-01 4.8030E-01 4.8030E-01 7 4.333E+00 2.000E+00 6.1003E-01 6.1003E-01 6.2790E-01 5.4334E-01 5.4334E-01 5.3371E-01 5.3371E-01 8 4.500E+00 3.000E+00 4.1980E-01 4.1980E-01 4.3578E-01 6.5718E-01 6.5718E-01 6.4676E-01 6.4676E-01 9 4.667E+00 4.000E+00 2.7408E-01 2.7408E-01 2.8623E-01 7.6027E-01 7.6027E-01 7.5109E-01 7.5109E-01 10 4.833E+00 5.000E+00 1.7239E-01 1.7239E-01 1.8081E-01 8.4165E-01 8.4165E-01 8.3460E-01 8.3460E-01 11 5.000E+00 6.000E+00 1.0560E-01 1.0560E-01 1.1109E-01 8.9978E-01 8.9978E-01 8.9486E-01 8.9486E-01 12 5.167E+00 7.000E+00 6.3488E-02 6.3488E-02 6.6930E-02 9.3849E-01 9.3849E-01 9.3526E-01 9.3526E-01 13 5.333E+00 8.000E+00 3.7663E-02 3.7663E-02 3.9766E-02 9.6304E-01 9.6304E-01 9.6101E-01 9.6101E-01 14 5.500E+00 9.000E+00 2.2134E-02 2.2134E-02 2.3395E-02 9.7811E-01 9.7811E-01 9.7688E-01 9.7688E-01 15 5.667E+00 1.000E+01 1.2920E-02 1.2920E-02 1.3667E-02 9.8716E-01 9.8716E-01 9.8643E-01 9.8643E-01 16 6.083E+00 1.250E+01 3.3043E-03 3.3043E-03 3.4990E-03 9.9670E-01 9.9670E-01 9.9651E-01 9.9651E-01 17 6.500E+00 1.500E+01 8.3392E-04 8.3392E-04 8.8345E-04 9.9917E-01 9.9917E-01 9.9912E-01 9.9912E-01 18 6.917E+00 1.750E+01 2.0928E-04 2.0928E-04 2.2176E-04 9.9979E-01 9.9979E-01 9.9978E-01 9.9978E-01 19 7.333E+00 2.000E+01 5.2397E-05 5.2397E-05 5.5524E-05 9.9995E-01 9.9995E-01 9.9994E-01 9.9994E-01 20 8.167E+00 2.500E+01 3.2763E-06 3.2763E-06 3.4721E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 9.000E+00 3.000E+01 2.0469E-07 2.0469E-07 2.1692E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 9.833E+00 3.500E+01 1.2786E-08 1.2786E-08 1.3550E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 4.000E+00 1.000E-01 9.8641E-01 9.8641E-01 9.8838E-01 3.7291E-01 3.7291E-01 3.7218E-01 3.7218E-01 25 4.000E+00 2.500E-01 9.6362E-01 9.6362E-01 9.6842E-01 3.8151E-01 3.8151E-01 3.7968E-01 3.7968E-01 26 4.000E+00 5.000E-01 9.1984E-01 9.1984E-01 9.2898E-01 3.9858E-01 3.9858E-01 3.9496E-01 3.9496E-01 27 4.001E+00 1.000E+00 8.1508E-01 8.1508E-01 8.3119E-01 4.4261E-01 4.4261E-01 4.3553E-01 4.3553E-01 28 4.001E+00 1.500E+00 6.9630E-01 6.9630E-01 7.1684E-01 4.9843E-01 4.9843E-01 4.8829E-01 4.8829E-01 29 4.001E+00 2.000E+00 5.7389E-01 5.7389E-01 5.9634E-01 5.6333E-01 5.6333E-01 5.5083E-01 5.5083E-01 30 4.002E+00 3.000E+00 3.5111E-01 3.5111E-01 3.7148E-01 7.0391E-01 7.0391E-01 6.8971E-01 6.8971E-01 31 4.003E+00 4.000E+00 1.8769E-01 1.8769E-01 2.0205E-01 8.2887E-01 8.2887E-01 8.1705E-01 8.1705E-01 32 4.003E+00 5.000E+00 8.8118E-02 8.8118E-02 9.6456E-02 9.1565E-01 9.1565E-01 9.0805E-01 9.0805E-01 33 4.004E+00 6.000E+00 3.6515E-02 3.6515E-02 4.0617E-02 9.6414E-01 9.6414E-01 9.6020E-01 9.6020E-01 34 4.005E+00 7.000E+00 1.3418E-02 1.3418E-02 1.5157E-02 9.8667E-01 9.8667E-01 9.8496E-01 9.8496E-01 35 4.006E+00 8.000E+00 4.3914E-03 4.3914E-03 5.0351E-03 9.9562E-01 9.9562E-01 9.9498E-01 9.9498E-01 36 4.006E+00 9.000E+00 1.2854E-03 1.2854E-03 1.4952E-03 9.9872E-01 9.9872E-01 9.9851E-01 9.9851E-01 37 4.007E+00 1.000E+01 3.3785E-04 3.3785E-04 3.9846E-04 9.9966E-01 9.9966E-01 9.9960E-01 9.9960E-01 38 4.009E+00 1.250E+01 7.6534E-06 7.6534E-06 9.3252E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 39 4.010E+00 1.500E+01 9.5511E-08 9.5511E-08 1.1991E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 40 4.012E+00 1.750E+01 6.8859E-10 6.8859E-10 8.8867E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 4.014E+00 2.000E+01 2.9917E-12 2.9917E-12 3.9607E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 4.017E+00 2.500E+01 1.4314E-17 1.4314E-17 1.9834E-17 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.021E+00 3.000E+01 1.3533E-23 1.3533E-23 1.9507E-23 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.024E+00 3.500E+01 3.1183E-30 3.1183E-30 4.6528E-30 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 4.000E-01 1.667E-02 0.0000E+00 1.0000E-01 0.0000E+00 2.5000E-01 3 1.000E+00 4.167E-02 0.0000E+00 2.5000E-01 0.0000E+00 2.5000E-01 4 2.000E+00 8.333E-02 0.0000E+00 5.0000E-01 0.0000E+00 2.5000E-01 5 4.000E+00 1.667E-01 0.0000E+00 1.0000E+00 0.0000E+00 2.5000E-01 6 6.000E+00 2.500E-01 0.0000E+00 1.5000E+00 0.0000E+00 2.5000E-01 7 8.000E+00 3.333E-01 0.0000E+00 2.0000E+00 0.0000E+00 2.5000E-01 8 1.200E+01 5.000E-01 0.0000E+00 3.0000E+00 0.0000E+00 2.5000E-01 9 1.600E+01 6.667E-01 0.0000E+00 4.0000E+00 0.0000E+00 2.5000E-01 10 2.000E+01 8.333E-01 0.0000E+00 5.0000E+00 0.0000E+00 2.5000E-01 11 2.400E+01 1.000E+00 0.0000E+00 6.0000E+00 0.0000E+00 2.5000E-01 12 2.800E+01 1.167E+00 0.0000E+00 7.0000E+00 0.0000E+00 2.5000E-01 13 3.200E+01 1.333E+00 0.0000E+00 8.0000E+00 0.0000E+00 2.5000E-01 14 3.600E+01 1.500E+00 0.0000E+00 9.0000E+00 0.0000E+00 2.5000E-01 15 4.000E+01 1.667E+00 0.0000E+00 1.0000E+01 0.0000E+00 2.5000E-01 16 5.000E+01 2.083E+00 0.0000E+00 1.2500E+01 0.0000E+00 2.5000E-01 17 6.000E+01 2.500E+00 0.0000E+00 1.5000E+01 0.0000E+00 2.5000E-01 18 7.000E+01 2.917E+00 0.0000E+00 1.7500E+01 0.0000E+00 2.5000E-01 19 8.000E+01 3.333E+00 0.0000E+00 2.0000E+01 0.0000E+00 2.5000E-01 20 1.000E+02 4.167E+00 0.0000E+00 2.5000E+01 0.0000E+00 2.5000E-01 21 1.200E+02 5.000E+00 0.0000E+00 3.0000E+01 0.0000E+00 2.5000E-01 22 1.400E+02 5.833E+00 0.0000E+00 3.5000E+01 0.0000E+00 2.5000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.667E-03 6.944E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E+01 25 4.167E-03 1.736E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E+01 26 8.333E-03 3.472E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E+01 27 1.667E-02 6.944E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E+01 28 2.500E-02 1.042E-03 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E+01 29 3.333E-02 1.389E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E+01 30 5.000E-02 2.083E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E+01 31 6.667E-02 2.778E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E+01 32 8.333E-02 3.472E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E+01 33 1.000E-01 4.167E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E+01 34 1.167E-01 4.861E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E+01 35 1.333E-01 5.556E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E+01 36 1.500E-01 6.250E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E+01 37 1.667E-01 6.944E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E+01 38 2.083E-01 8.681E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E+01 39 2.500E-01 1.042E-02 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E+01 40 2.917E-01 1.215E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E+01 41 3.333E-01 1.389E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E+01 42 4.167E-01 1.736E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E+01 43 5.000E-01 2.083E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E+01 44 5.833E-01 2.431E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 5.73333E-03 VC 2.00J 25-SEP-2003 20-NOV-2003 10:33:38 AM