VC 2.00J 25-SEP-2003 20-NOV-2003 05:32:32 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\ppc1.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\ppc1.radx (8 exposures) XDAT: ..\xdat\ppc1.xdat (8 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 7.6195843E-05 2202 CLRP RHT 1.00000E-03 2.40000E+01 1.00000E+01 2.4995675E+00 2201 CLRP RHT 1.00000E-03 2.40000E+01 2.00000E+00 8.6337452E+00 1002 IRAD CL 1.00000E+00 2.00000E+01 5.00000E+00 1.0000000E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 1.12393E-02 (nfom=596, nsim=4768, nmx=8, nox=8, ndf=3, nap=4) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-1.470E-01 max=1.726E-01, mean=-1.2447E-02, stdev=9.5197E-02, var=9.0625E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.36982)= 7.3608E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93782)=5.939E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-5.198E-02 max=6.104E-02, mean=-4.4007E-03, stdev=3.3657E-02, var=1.1328E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.36982)= 7.3608E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93782)=5.939E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 7.17785E-12 4.41151E-03 25.000000 Complex DSB = 2.87114E-13 1.76460E-04 1.000000 Total DSB = 7.46496E-12 4.58797E-03 26.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 5.333333E-03 (=0.533%) PHI2= 5.333333E-03 (=0.533%) (1-A1)*PHI1= 5.333333E-03 (=0.533%) (1-A2)*PHI2= 5.333333E-03 (=0.533%) (1-A1)*(1-PHI1)= 9.946667E-01 (=99.467%) (1-A2)*(1-PHI2)= 9.946667E-01 (=99.467%) RHT1= 8.633745 h (=518.02 minute) RHT2= 2.499568 h (=149.97 minute) LAM1= 8.0283488E-02 (1/h) LAM2= 2.7730684E-01 (1/h) BMR= 7.6195843E-05 (1/h) LAM1/BMR= 1.0536466E+03 LAM2/BMR= 3.6393959E+03 (LAM1+LAM2)/BMR= 4.6930425E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.3333E-01 + 5.3333E-03 = 1.3866666E-01 (1/Gy) beta: 7.3869E-02 + 1.3370E-03 = 7.5205756E-02 (1/Gy^2) alpha/beta: 1.8438304 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (PPC1 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 2.4040E+01 6.0100E+00 2.5000E-01 1.03048E-01 1.25E-01 9.88925E-02 -4.2020E-02 2 4.7872E+01 1.1968E+01 2.5000E-01 4.63300E-03 1.25E-01 4.31851E-03 -7.2824E-02 3 7.1772E+01 1.7943E+01 2.5000E-01 1.60000E-04 1.25E-01 1.70265E-04 6.0289E-02 4 3.3580E-02 2.0148E+00 6.0000E+01 5.54660E-01 1.25E-01 5.50783E-01 -7.0398E-03 5 6.6613E-02 3.9968E+00 6.0000E+01 1.86990E-01 1.25E-01 1.78546E-01 -4.7295E-02 6 9.9722E-02 5.9833E+00 6.0000E+01 4.05600E-02 1.25E-01 3.53609E-02 -1.4703E-01 7 1.3289E-01 7.9735E+00 6.0000E+01 3.68000E-03 1.25E-01 4.44786E-03 1.7264E-01 8 1.6624E-01 9.9746E+00 6.0000E+01 3.70000E-04 1.25E-01 3.64069E-04 -1.6290E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-1.470E-01 max=1.726E-01, mean=-1.2447E-02, stdev=9.5197E-02, var=9.0625E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.36982)= 7.3608E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93782)=5.939E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-5.198E-02 max=6.104E-02, mean=-4.4007E-03, stdev=3.3657E-02, var=1.1328E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.36982)= 7.3608E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93782)=5.939E-01 (passed normality test) NOX=8, NPAR=4 CFE.SF: Cell survival data for PPC1 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 2.4040E+01 6.0100E+00 2.5000E-01 8.96952E-01 1.03048E-01 1.00E+01 2 2 4.7872E+01 1.1968E+01 2.5000E-01 9.95367E-01 4.63300E-03 1.00E+01 3 3 7.1772E+01 1.7943E+01 2.5000E-01 9.99840E-01 1.60000E-04 1.00E+01 4 4 3.3580E-02 2.0148E+00 6.0000E+01 4.45340E-01 5.54660E-01 1.00E+01 5 5 6.6613E-02 3.9968E+00 6.0000E+01 8.13010E-01 1.86990E-01 1.00E+01 6 6 9.9722E-02 5.9833E+00 6.0000E+01 9.59440E-01 4.05600E-02 1.00E+01 7 7 1.3289E-01 7.9735E+00 6.0000E+01 9.96320E-01 3.68000E-03 1.00E+01 8 8 1.6624E-01 9.9746E+00 6.0000E+01 9.99630E-01 3.70000E-04 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (PPC1). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 2.404E+01 1.200E+01 4.000E+02 6.0100E+00 3.7813E-01 2.2726E+00 2 2 4.787E+01 1.200E+01 4.000E+02 1.1968E+01 4.4908E-01 5.3746E+00 3 3 7.177E+01 1.200E+01 4.000E+02 1.7943E+01 4.8712E-01 8.7403E+00 4 4 3.358E-02 1.200E+01 4.000E+02 2.0148E+00 2.9254E-01 5.8940E-01 5 5 6.661E-02 1.200E+01 4.000E+02 3.9968E+00 4.1951E-01 1.6767E+00 6 6 9.972E-02 1.200E+01 4.000E+02 5.9833E+00 5.3565E-01 3.2050E+00 7 7 1.329E-01 1.200E+01 4.000E+02 7.9735E+00 7.0293E-01 5.6048E+00 8 8 1.662E-01 1.200E+01 4.000E+02 9.9746E+00 7.9221E-01 7.9020E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.46678 VC 2.00J 25-SEP-2003 20-NOV-2003 05:33:00 PM