VC 2.00J 25-SEP-2003 20-NOV-2003 09:13:18 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\pc3.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\pc3.radx (6 exposures) XDAT: ..\xdat\pc3.xdat (6 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 5.8143562E-05 2200 CLRP RHT 1.00000E-03 2.40000E+01 6.00000E+00 5.3166260E+00 2201 CLRP RHT 1.00000E-03 2.40000E+01 1.00000E+00 5.3164918E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 1.63390E-02 (nfom=1138, nsim=6828, nmx=6, nox=6, ndf=2, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-1.673E-01 max=1.517E-01, mean=1.0655E-03, stdev=1.0738E-01, var=1.1532E-02 Student's T test (mean=0, NDF=2): Pr>ABS(0.02430)= 9.8282E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95200)=7.731E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-6.832E-02 max=6.194E-02, mean=4.3499E-04, stdev=4.3840E-02, var=1.9219E-03 Student's T test (mean=0, NDF=2): Pr>ABS(0.02430)= 9.8282E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95200)=7.731E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 1.000000E-02 (=1.000%) PHI2= 1.000000E-02 (=1.000%) (1-A1)*PHI1= 1.000000E-02 (=1.000%) (1-A2)*PHI2= 1.000000E-02 (=1.000%) (1-A1)*(1-PHI1)= 9.900000E-01 (=99.000%) (1-A2)*(1-PHI2)= 9.900000E-01 (=99.000%) RHT1= 5.316492 h (=318.99 minute) RHT2= 5.316626 h (=319.00 minute) LAM1= 1.3037680E-01 (1/h) LAM2= 1.3037351E-01 (1/h) BMR= 5.8143562E-05 (1/h) LAM1/BMR= 2.2423256E+03 LAM2/BMR= 2.2422690E+03 (LAM1+LAM2)/BMR= 4.4845946E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 3.0000E-01 + 1.0000E-01 = 4.0000000E-01 (1/Gy) beta: 6.4219E-02 + 2.1407E-02 = 8.5625928E-02 (1/Gy^2) alpha/beta: 4.6714822 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (PC3 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 1.7100E-02 1.0260E+00 6.0000E+01 6.45343E-01 1.67E-01 6.06815E-01 -6.3493E-02 2 3.3767E-02 2.0260E+00 6.0000E+01 3.08808E-01 1.67E-01 3.15560E-01 2.1396E-02 3 4.9867E-02 2.9920E+00 6.0000E+01 1.22397E-01 1.67E-01 1.44289E-01 1.5172E-01 4 6.6200E-02 3.9720E+00 6.0000E+01 6.57900E-02 1.67E-01 5.63590E-02 -1.6734E-01 5 8.3367E-02 5.0020E+00 6.0000E+01 1.75520E-02 1.67E-01 1.80026E-02 2.5030E-02 6 1.0008E-01 6.0050E+00 6.0000E+01 4.92200E-03 1.67E-01 5.12215E-03 3.9075E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-1.673E-01 max=1.517E-01, mean=1.0655E-03, stdev=1.0738E-01, var=1.1532E-02 Student's T test (mean=0, NDF=2): Pr>ABS(0.02430)= 9.8282E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95200)=7.731E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-6.832E-02 max=6.194E-02, mean=4.3499E-04, stdev=4.3840E-02, var=1.9219E-03 Student's T test (mean=0, NDF=2): Pr>ABS(0.02430)= 9.8282E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95200)=7.731E-01 (passed normality test) NOX=6, NPAR=3 CFE.SF: Cell survival data for PC3 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 1.7100E-02 1.0260E+00 6.0000E+01 3.54657E-01 6.45343E-01 1.00E+01 2 2 3.3767E-02 2.0260E+00 6.0000E+01 6.91192E-01 3.08808E-01 1.00E+01 3 3 4.9867E-02 2.9920E+00 6.0000E+01 8.77603E-01 1.22397E-01 1.00E+01 4 4 6.6200E-02 3.9720E+00 6.0000E+01 9.34210E-01 6.57900E-02 1.00E+01 5 5 8.3367E-02 5.0020E+00 6.0000E+01 9.82448E-01 1.75520E-02 1.00E+01 6 6 1.0008E-01 6.0050E+00 6.0000E+01 9.95078E-01 4.92200E-03 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (PC3). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 1.710E-02 1.200E+01 4.000E+02 1.0260E+00 4.2687E-01 4.3797E-01 2 2 3.377E-02 1.200E+01 4.000E+02 2.0260E+00 5.7998E-01 1.1750E+00 3 3 4.987E-02 1.200E+01 4.000E+02 2.9920E+00 7.0203E-01 2.1005E+00 4 4 6.620E-02 1.200E+01 4.000E+02 3.9720E+00 6.8512E-01 2.7213E+00 5 5 8.337E-02 1.200E+01 4.000E+02 5.0020E+00 8.0819E-01 4.0426E+00 6 6 1.001E-01 1.200E+01 4.000E+02 6.0050E+00 8.8494E-01 5.3140E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.64588 VC 2.00J 25-SEP-2003 20-NOV-2003 09:13:57 PM