VC 2.00J 25-SEP-2003 11-NOV-2003 03:02:08 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: p:\usr\bin\vc.exe p:\archive\human\prostate\pc3\tlk\pc3.inp FNI: P:\archive\human\Prostate\pc3\tlk\pc3.inp FNO: P:\archive\human\Prostate\pc3\tlk\pc3.out RADX: P:\archive\human\Prostate\pc3\tlk\pc3.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 3.207537E-03 (=0.321%) PHI2= 3.207537E-03 (=0.321%) (1-A1)*PHI1= 3.207537E-03 (=0.321%) (1-A2)*PHI2= 3.207537E-03 (=0.321%) (1-A1)*(1-PHI1)= 9.967925E-01 (=99.679%) (1-A2)*(1-PHI2)= 9.967925E-01 (=99.679%) RHT1= 0.250000 h (=15.00 minute) RHT2= 9.838932 h (=590.34 minute) LAM1= 2.7725887E+00 (1/h) LAM2= 7.0449435E-02 (1/h) BMR= 1.5520561E-04 (1/h) LAM1/BMR= 1.7863972E+04 LAM2/BMR= 4.5391037E+02 (LAM1+LAM2)/BMR= 1.8317883E+04 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 9.6226E-02 + 3.2075E-02 = 1.2830148E-01 (1/Gy) beta: 1.0259E-02 + 3.1227E-02 = 4.1485603E-02 (1/Gy^2) alpha/beta: 3.0926747 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 1.321E-02 1.137E-03 1.4345E-02 9.857570E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 3.427E-02 2.774E-03 3.7046E-02 9.636322E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 7.229E-02 5.329E-03 7.7620E-02 9.253159E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 1.580E-01 9.854E-03 1.6790E-01 8.454368E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 2.551E-01 1.370E-02 2.6881E-01 7.642888E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 3.618E-01 1.696E-02 3.7875E-01 6.847155E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 5.984E-01 2.209E-02 6.2053E-01 5.376575E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 8.589E-01 2.580E-02 8.8468E-01 4.128463E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 1.137E+00 2.848E-02 1.1650E+00 3.119235E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 1.427E+00 3.041E-02 1.4570E+00 2.329324E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 1.726E+00 3.181E-02 1.7575E+00 1.724805E-01 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 2.031E+00 3.282E-02 2.0640E+00 1.269391E-01 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 2.341E+00 3.355E-02 2.3750E+00 9.301035E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 2.655E+00 3.408E-02 2.6892E+00 6.793278E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 3.449E+00 3.484E-02 3.4835E+00 3.070054E-02 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 4.249E+00 3.518E-02 4.2844E+00 1.378143E-02 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 5.053E+00 3.533E-02 5.0884E+00 6.168020E-03 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 5.858E+00 3.540E-02 5.8936E+00 2.756897E-03 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 7.470E+00 3.544E-02 7.5056E+00 5.499759E-04 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 9.083E+00 3.545E-02 9.1182E+00 1.096552E-04 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 1.070E+01 3.545E-02 1.0731E+01 2.186087E-05 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 1.324E-02 1.153E-03 1.4393E-02 9.857097E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 3.465E-02 2.872E-03 3.7520E-02 9.631753E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 7.442E-02 5.709E-03 8.0127E-02 9.229990E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 1.691E-01 1.128E-02 1.8036E-01 8.349729E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 2.835E-01 1.673E-02 3.0020E-01 7.406691E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 4.172E-01 2.204E-02 4.3919E-01 6.445559E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 7.405E-01 3.232E-02 7.7282E-01 4.617084E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 1.136E+00 4.213E-02 1.1778E+00 3.079587E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 1.599E+00 5.153E-02 1.6509E+00 1.918833E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 2.129E+00 6.053E-02 2.1890E+00 1.120254E-01 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 2.720E+00 6.915E-02 2.7894E+00 6.145605E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 3.372E+00 7.742E-02 3.4494E+00 3.176435E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 4.081E+00 8.537E-02 4.1665E+00 1.550718E-02 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 4.845E+00 9.300E-02 4.9382E+00 7.167533E-03 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 6.982E+00 1.108E-01 7.0926E+00 8.312723E-04 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 9.417E+00 1.271E-01 9.5437E+00 7.165276E-05 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 1.212E+01 1.420E-01 1.2264E+01 4.717823E-06 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 1.507E+01 1.556E-01 1.5230E+01 2.430347E-07 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 2.164E+01 1.798E-01 2.1817E+01 3.351224E-10 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 2.896E+01 2.006E-01 2.9163E+01 2.161695E-13 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 3.694E+01 2.186E-01 3.7158E+01 7.286364E-17 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 4.017E+00 1.000E-01 2.500E-01 9.8576E-01 9.8576E-01 1.0000E+00 9.8576E-01 9.8576E-01 9.8688E-01 3 4.042E+00 2.500E-01 2.500E-01 9.6363E-01 9.6363E-01 1.0000E+00 9.6363E-01 9.6363E-01 9.6631E-01 4 4.083E+00 5.000E-01 2.500E-01 9.2532E-01 9.2532E-01 1.0000E+00 9.2532E-01 9.2532E-01 9.3026E-01 5 4.167E+00 1.000E+00 2.500E-01 8.4544E-01 8.4544E-01 1.0000E+00 8.4544E-01 8.4544E-01 8.5381E-01 6 4.250E+00 1.500E+00 2.500E-01 7.6429E-01 7.6429E-01 1.0000E+00 7.6429E-01 7.6429E-01 7.7483E-01 7 4.333E+00 2.000E+00 2.500E-01 6.8472E-01 6.8472E-01 1.0000E+00 6.8472E-01 6.8472E-01 6.9643E-01 8 4.500E+00 3.000E+00 2.500E-01 5.3766E-01 5.3766E-01 1.0000E+00 5.3766E-01 5.3766E-01 5.4967E-01 9 4.667E+00 4.000E+00 2.500E-01 4.1285E-01 4.1285E-01 1.0000E+00 4.1285E-01 4.1285E-01 4.2364E-01 10 4.833E+00 5.000E+00 2.500E-01 3.1192E-01 3.1192E-01 1.0000E+00 3.1192E-01 3.1192E-01 3.2093E-01 11 5.000E+00 6.000E+00 2.500E-01 2.3293E-01 2.3293E-01 1.0000E+00 2.3293E-01 2.3293E-01 2.4012E-01 12 5.167E+00 7.000E+00 2.500E-01 1.7248E-01 1.7248E-01 1.0000E+00 1.7248E-01 1.7248E-01 1.7805E-01 13 5.333E+00 8.000E+00 2.500E-01 1.2694E-01 1.2694E-01 1.0000E+00 1.2694E-01 1.2694E-01 1.3117E-01 14 5.500E+00 9.000E+00 2.500E-01 9.3010E-02 9.3010E-02 1.0000E+00 9.3010E-02 9.3010E-02 9.6184E-02 15 5.667E+00 1.000E+01 2.500E-01 6.7933E-02 6.7933E-02 1.0000E+00 6.7933E-02 6.7933E-02 7.0287E-02 16 6.083E+00 1.250E+01 2.500E-01 3.0701E-02 3.0701E-02 1.0000E+00 3.0701E-02 3.0701E-02 3.1789E-02 17 6.500E+00 1.500E+01 2.500E-01 1.3781E-02 1.3781E-02 1.0000E+00 1.3781E-02 1.3781E-02 1.4275E-02 18 6.917E+00 1.750E+01 2.500E-01 6.1680E-03 6.1680E-03 1.0000E+00 6.1680E-03 6.1680E-03 6.3898E-03 19 7.333E+00 2.000E+01 2.500E-01 2.7569E-03 2.7569E-03 1.0000E+00 2.7569E-03 2.7569E-03 2.8562E-03 20 8.167E+00 2.500E+01 2.500E-01 5.4998E-04 5.4998E-04 1.0000E+00 5.4998E-04 5.4998E-04 5.6982E-04 21 9.000E+00 3.000E+01 2.500E-01 1.0966E-04 1.0966E-04 1.0000E+00 1.0966E-04 1.0966E-04 1.1361E-04 22 9.833E+00 3.500E+01 2.500E-01 2.1861E-05 2.1861E-05 1.0000E+00 2.1861E-05 2.1861E-05 2.2650E-05 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 4.000E+00 1.000E-01 6.000E+01 9.8571E-01 9.8571E-01 1.0000E+00 9.8571E-01 9.8571E-01 9.8685E-01 25 4.000E+00 2.500E-01 6.000E+01 9.6318E-01 9.6318E-01 1.0000E+00 9.6318E-01 9.6318E-01 9.6595E-01 26 4.000E+00 5.000E-01 6.000E+01 9.2300E-01 9.2300E-01 1.0000E+00 9.2300E-01 9.2300E-01 9.2828E-01 27 4.001E+00 1.000E+00 6.000E+01 8.3497E-01 8.3497E-01 1.0000E+00 8.3497E-01 8.3497E-01 8.4445E-01 28 4.001E+00 1.500E+00 6.000E+01 7.4067E-01 7.4067E-01 1.0000E+00 7.4067E-01 7.4067E-01 7.5316E-01 29 4.001E+00 2.000E+00 6.000E+01 6.4456E-01 6.4456E-01 1.0000E+00 6.4456E-01 6.4456E-01 6.5892E-01 30 4.002E+00 3.000E+00 6.000E+01 4.6171E-01 4.6171E-01 1.0000E+00 4.6171E-01 4.6171E-01 4.7687E-01 31 4.003E+00 4.000E+00 6.000E+01 3.0796E-01 3.0796E-01 1.0000E+00 3.0796E-01 3.0796E-01 3.2121E-01 32 4.003E+00 5.000E+00 6.000E+01 1.9188E-01 1.9188E-01 1.0000E+00 1.9188E-01 1.9188E-01 2.0203E-01 33 4.004E+00 6.000E+00 6.000E+01 1.1203E-01 1.1203E-01 1.0000E+00 1.1203E-01 1.1203E-01 1.1902E-01 34 4.005E+00 7.000E+00 6.000E+01 6.1456E-02 6.1456E-02 1.0000E+00 6.1456E-02 6.1456E-02 6.5856E-02 35 4.006E+00 8.000E+00 6.000E+01 3.1764E-02 3.1764E-02 1.0000E+00 3.1764E-02 3.1764E-02 3.4321E-02 36 4.006E+00 9.000E+00 6.000E+01 1.5507E-02 1.5507E-02 1.0000E+00 1.5507E-02 1.5507E-02 1.6889E-02 37 4.007E+00 1.000E+01 6.000E+01 7.1675E-03 7.1675E-03 1.0000E+00 7.1675E-03 7.1675E-03 7.8661E-03 38 4.009E+00 1.250E+01 6.000E+01 8.3127E-04 8.3127E-04 1.0000E+00 8.3127E-04 8.3127E-04 9.2872E-04 39 4.010E+00 1.500E+01 6.000E+01 7.1653E-05 7.1653E-05 1.0000E+00 7.1653E-05 7.1653E-05 8.1364E-05 40 4.012E+00 1.750E+01 6.000E+01 4.7178E-06 4.7178E-06 1.0000E+00 4.7178E-06 4.7178E-06 5.4375E-06 41 4.014E+00 2.000E+01 6.000E+01 2.4303E-07 2.4303E-07 1.0000E+00 2.4303E-07 2.4303E-07 2.8396E-07 42 4.017E+00 2.500E+01 6.000E+01 3.3512E-10 3.3512E-10 1.0000E+00 3.3512E-10 3.3512E-10 4.0114E-10 43 4.021E+00 3.000E+01 6.000E+01 2.1617E-13 2.1617E-13 1.0000E+00 2.1617E-13 2.1617E-13 2.6419E-13 44 4.024E+00 3.500E+01 6.000E+01 7.2864E-17 7.2864E-17 1.0000E+00 7.2864E-17 7.2864E-17 9.0668E-17 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 2.500E-01 3.986E+00 0.00E+00 3.98565E+00 1.670E-05 1.670E-05 1.694E-05 3 2.500E-01 2.500E-01 9.963E+00 0.00E+00 9.96295E+00 4.080E-05 4.080E-05 4.234E-05 4 5.000E-01 2.500E-01 1.992E+01 0.00E+00 1.99224E+01 7.834E-05 7.834E-05 8.467E-05 5 1.000E+00 2.500E-01 3.983E+01 0.00E+00 3.98321E+01 1.431E-04 1.431E-04 1.693E-04 6 1.500E+00 2.500E-01 5.973E+01 0.00E+00 5.97312E+01 1.940E-04 1.940E-04 2.538E-04 7 2.000E+00 2.500E-01 7.962E+01 0.00E+00 7.96212E+01 2.317E-04 2.317E-04 3.383E-04 8 3.000E+00 2.500E-01 1.194E+02 0.00E+00 1.19379E+02 2.727E-04 2.727E-04 5.072E-04 9 4.000E+00 2.500E-01 1.591E+02 0.00E+00 1.59115E+02 2.791E-04 2.791E-04 6.760E-04 10 5.000E+00 2.500E-01 1.988E+02 0.00E+00 1.98835E+02 2.635E-04 2.635E-04 8.447E-04 11 6.000E+00 2.500E-01 2.385E+02 0.00E+00 2.38543E+02 2.360E-04 2.360E-04 1.013E-03 12 7.000E+00 2.500E-01 2.782E+02 0.00E+00 2.78243E+02 2.038E-04 2.038E-04 1.182E-03 13 8.000E+00 2.500E-01 3.179E+02 0.00E+00 3.17936E+02 1.714E-04 1.714E-04 1.350E-03 14 9.000E+00 2.500E-01 3.576E+02 0.00E+00 3.57625E+02 1.413E-04 1.413E-04 1.519E-03 15 1.000E+01 2.500E-01 3.973E+02 0.00E+00 3.97311E+02 1.146E-04 1.146E-04 1.687E-03 16 1.250E+01 2.500E-01 4.965E+02 0.00E+00 4.96517E+02 6.472E-05 6.472E-05 2.108E-03 17 1.500E+01 2.500E-01 5.957E+02 0.00E+00 5.95716E+02 3.485E-05 3.485E-05 2.529E-03 18 1.750E+01 2.500E-01 6.949E+02 0.00E+00 6.94912E+02 1.819E-05 1.819E-05 2.949E-03 19 2.000E+01 2.500E-01 7.941E+02 0.00E+00 7.94106E+02 9.289E-06 9.289E-06 3.369E-03 20 2.500E+01 2.500E-01 9.925E+02 0.00E+00 9.92494E+02 2.315E-06 2.315E-06 4.209E-03 21 3.000E+01 2.500E-01 1.191E+03 0.00E+00 1.19088E+03 5.536E-07 5.536E-07 5.048E-03 22 3.500E+01 2.500E-01 1.389E+03 0.00E+00 1.38927E+03 1.287E-07 1.287E-07 5.887E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.000E+01 3.986E+00 0.00E+00 3.98561E+00 1.670E-05 1.670E-05 1.694E-05 25 2.500E-01 6.000E+01 9.962E+00 0.00E+00 9.96248E+00 4.078E-05 4.078E-05 4.234E-05 26 5.000E-01 6.000E+01 1.992E+01 0.00E+00 1.99199E+01 7.814E-05 7.814E-05 8.466E-05 27 1.000E+00 6.000E+01 3.982E+01 0.00E+00 3.98196E+01 1.413E-04 1.413E-04 1.692E-04 28 1.500E+00 6.000E+01 5.970E+01 0.00E+00 5.96998E+01 1.879E-04 1.879E-04 2.537E-04 29 2.000E+00 6.000E+01 7.956E+01 0.00E+00 7.95608E+01 2.179E-04 2.179E-04 3.381E-04 30 3.000E+00 6.000E+01 1.192E+02 0.00E+00 1.19227E+02 2.339E-04 2.339E-04 5.066E-04 31 4.000E+00 6.000E+01 1.588E+02 0.00E+00 1.58822E+02 2.078E-04 2.078E-04 6.748E-04 32 5.000E+00 6.000E+01 1.983E+02 0.00E+00 1.98349E+02 1.617E-04 1.617E-04 8.426E-04 33 6.000E+00 6.000E+01 2.378E+02 0.00E+00 2.37811E+02 1.132E-04 1.132E-04 1.010E-03 34 7.000E+00 6.000E+01 2.772E+02 0.00E+00 2.77211E+02 7.236E-05 7.236E-05 1.177E-03 35 8.000E+00 6.000E+01 3.166E+02 0.00E+00 3.16551E+02 4.271E-05 4.271E-05 1.344E-03 36 9.000E+00 6.000E+01 3.558E+02 0.00E+00 3.55834E+02 2.343E-05 2.343E-05 1.511E-03 37 1.000E+01 6.000E+01 3.951E+02 0.00E+00 3.95062E+02 1.202E-05 1.202E-05 1.678E-03 38 1.250E+01 6.000E+01 4.929E+02 0.00E+00 4.92907E+02 1.740E-06 1.740E-06 2.093E-03 39 1.500E+01 6.000E+01 5.905E+02 0.00E+00 5.90456E+02 1.796E-07 1.796E-07 2.506E-03 40 1.750E+01 6.000E+01 6.877E+02 0.00E+00 6.87736E+02 1.377E-08 1.377E-08 2.919E-03 41 2.000E+01 6.000E+01 7.848E+02 0.00E+00 7.84770E+02 8.092E-10 8.092E-10 3.330E-03 42 2.500E+01 6.000E+01 9.782E+02 0.00E+00 9.78183E+02 1.390E-12 1.390E-12 4.149E-03 43 3.000E+01 6.000E+01 1.171E+03 0.00E+00 1.17084E+03 1.073E-15 1.073E-15 4.964E-03 44 3.500E+01 6.000E+01 1.363E+03 0.00E+00 1.36284E+03 4.208E-19 4.208E-19 5.775E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 2.500E-01 3.986E+00 1.670E-05 1.694E-05 6.8994E-05 6.9196E-05 6.8211E-05 3 2.500E-01 2.500E-01 9.963E+00 4.080E-05 4.234E-05 6.8992E-05 6.9497E-05 6.6970E-05 4 5.000E-01 2.500E-01 1.992E+01 7.834E-05 8.467E-05 6.8989E-05 6.9999E-05 6.4771E-05 5 1.000E+00 2.500E-01 3.983E+01 1.431E-04 1.693E-04 6.8984E-05 7.1003E-05 6.0028E-05 6 1.500E+00 2.500E-01 5.973E+01 1.940E-04 2.538E-04 6.8978E-05 7.2005E-05 5.5033E-05 7 2.000E+00 2.500E-01 7.962E+01 2.317E-04 3.383E-04 6.8972E-05 7.3008E-05 4.9989E-05 8 3.000E+00 2.500E-01 1.194E+02 2.727E-04 5.072E-04 6.8960E-05 7.5011E-05 4.0330E-05 9 4.000E+00 2.500E-01 1.591E+02 2.791E-04 6.760E-04 6.8949E-05 7.7012E-05 3.1794E-05 10 5.000E+00 2.500E-01 1.988E+02 2.635E-04 8.447E-04 6.8937E-05 7.9013E-05 2.4646E-05 11 6.000E+00 2.500E-01 2.385E+02 2.360E-04 1.013E-03 6.8925E-05 8.1012E-05 1.8870E-05 12 7.000E+00 2.500E-01 2.782E+02 2.038E-04 1.182E-03 6.8914E-05 8.3011E-05 1.4318E-05 13 8.000E+00 2.500E-01 3.179E+02 1.714E-04 1.350E-03 6.8902E-05 8.5009E-05 1.0791E-05 14 9.000E+00 2.500E-01 3.576E+02 1.413E-04 1.519E-03 6.8890E-05 8.7007E-05 8.0925E-06 15 1.000E+01 2.500E-01 3.973E+02 1.146E-04 1.687E-03 6.8879E-05 8.9004E-05 6.0463E-06 16 1.250E+01 2.500E-01 4.965E+02 6.472E-05 2.108E-03 6.8850E-05 9.3994E-05 2.8857E-06 17 1.500E+01 2.500E-01 5.957E+02 3.485E-05 2.529E-03 6.8821E-05 9.8982E-05 1.3641E-06 18 1.750E+01 2.500E-01 6.949E+02 1.819E-05 2.949E-03 6.8792E-05 1.0397E-04 6.4128E-07 19 2.000E+01 2.500E-01 7.941E+02 9.289E-06 3.369E-03 6.8763E-05 1.0895E-04 3.0037E-07 20 2.500E+01 2.500E-01 9.925E+02 2.315E-06 4.209E-03 6.8705E-05 1.1891E-04 6.5400E-08 21 3.000E+01 2.500E-01 1.191E+03 5.536E-07 5.048E-03 6.8647E-05 1.2887E-04 1.4131E-08 22 3.500E+01 2.500E-01 1.389E+03 1.287E-07 5.887E-03 6.8589E-05 1.3881E-04 3.0345E-09 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.000E+01 3.986E+00 1.670E-05 1.694E-05 6.8994E-05 6.9196E-05 6.8207E-05 25 2.500E-01 6.000E+01 9.962E+00 4.078E-05 4.234E-05 6.8992E-05 6.9497E-05 6.6938E-05 26 5.000E-01 6.000E+01 1.992E+01 7.814E-05 8.466E-05 6.8989E-05 6.9999E-05 6.4609E-05 27 1.000E+00 6.000E+01 3.982E+01 1.413E-04 1.692E-04 6.8984E-05 7.1002E-05 5.9285E-05 28 1.500E+00 6.000E+01 5.970E+01 1.879E-04 2.537E-04 6.8978E-05 7.2004E-05 5.3331E-05 29 2.000E+00 6.000E+01 7.956E+01 2.179E-04 3.381E-04 6.8972E-05 7.3005E-05 4.7056E-05 30 3.000E+00 6.000E+01 1.192E+02 2.339E-04 5.066E-04 6.8960E-05 7.5003E-05 3.4630E-05 31 4.000E+00 6.000E+01 1.588E+02 2.078E-04 6.748E-04 6.8949E-05 7.6997E-05 2.3712E-05 32 5.000E+00 6.000E+01 1.983E+02 1.617E-04 8.426E-04 6.8937E-05 7.8988E-05 1.5157E-05 33 6.000E+00 6.000E+01 2.378E+02 1.132E-04 1.010E-03 6.8926E-05 8.0975E-05 9.0713E-06 34 7.000E+00 6.000E+01 2.772E+02 7.236E-05 1.177E-03 6.8914E-05 8.2959E-05 5.0983E-06 35 8.000E+00 6.000E+01 3.166E+02 4.271E-05 1.344E-03 6.8902E-05 8.4939E-05 2.6980E-06 36 9.000E+00 6.000E+01 3.558E+02 2.343E-05 1.511E-03 6.8891E-05 8.6916E-05 1.3478E-06 37 1.000E+01 6.000E+01 3.951E+02 1.202E-05 1.678E-03 6.8879E-05 8.8890E-05 6.3712E-07 38 1.250E+01 6.000E+01 4.929E+02 1.740E-06 2.093E-03 6.8851E-05 9.3813E-05 7.7984E-08 39 1.500E+01 6.000E+01 5.905E+02 1.796E-07 2.506E-03 6.8822E-05 9.8718E-05 7.0734E-09 40 1.750E+01 6.000E+01 6.877E+02 1.377E-08 2.919E-03 6.8794E-05 1.0361E-04 4.8880E-10 41 2.000E+01 6.000E+01 7.848E+02 8.092E-10 3.330E-03 6.8765E-05 1.0848E-04 2.6365E-11 42 2.500E+01 6.000E+01 9.782E+02 1.390E-12 4.149E-03 6.8709E-05 1.1820E-04 3.9610E-14 43 3.000E+01 6.000E+01 1.171E+03 1.073E-15 4.964E-03 6.8653E-05 1.2786E-04 2.7640E-17 44 3.500E+01 6.000E+01 1.363E+03 4.208E-19 5.775E-03 6.8597E-05 1.3749E-04 1.0018E-20 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.1283 (1/Gy), alpha/beta = 3.0927 (Gy), lamda1 = 2.773E+00 (1/h), lamda2 = 7.045E-02 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 7.137E-01 9.907E-01 3.652E+00 9.8687E-01 9.857570E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 4.774E-01 9.769E-01 1.917E+00 9.6629E-01 9.636322E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 2.959E-01 9.546E-01 1.299E+00 9.3019E-01 9.253159E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 1.641E-01 9.123E-01 9.546E-01 8.5345E-01 8.454368E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 1.130E-01 8.728E-01 8.180E-01 7.7384E-01 7.642888E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 8.610E-02 8.359E-01 7.361E-01 6.9451E-01 6.847155E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 5.831E-02 7.690E-01 6.311E-01 5.4531E-01 5.376575E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 4.407E-02 7.101E-01 5.596E-01 4.1676E-01 4.128463E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 3.542E-02 6.582E-01 5.047E-01 3.1209E-01 3.119235E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 2.960E-02 6.123E-01 4.601E-01 2.3015E-01 2.329324E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 2.543E-02 5.714E-01 4.227E-01 1.6776E-01 1.724805E-01 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 2.229E-02 5.349E-01 3.908E-01 1.2122E-01 1.269391E-01 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 1.984E-02 5.023E-01 3.632E-01 8.7019E-02 9.301035E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 1.787E-02 4.729E-01 3.390E-01 6.2156E-02 6.793278E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 1.432E-02 4.114E-01 2.900E-01 2.6415E-02 3.070054E-02 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 1.195E-02 3.628E-01 2.528E-01 1.1092E-02 1.378143E-02 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 1.025E-02 3.239E-01 2.238E-01 4.6302E-03 6.168020E-03 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 8.976E-03 2.921E-01 2.005E-01 1.9271E-03 2.756897E-03 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 7.187E-03 2.436E-01 1.658E-01 3.3262E-04 5.499759E-04 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 5.993E-03 2.086E-01 1.411E-01 5.7319E-05 1.096552E-04 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 5.139E-03 1.822E-01 1.228E-01 9.8736E-06 2.186087E-05 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 9.985E-01 1.000E+00 3.768E+00 9.8684E-01 9.857097E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 9.962E-01 9.999E-01 2.100E+00 9.6593E-01 9.631753E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.923E-01 9.998E-01 1.540E+00 9.2821E-01 9.229990E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 9.848E-01 9.996E-01 1.255E+00 8.4399E-01 8.349729E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 9.773E-01 9.994E-01 1.154E+00 7.5184E-01 7.406691E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.699E-01 9.992E-01 1.100E+00 6.5625E-01 6.445559E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 9.553E-01 9.988E-01 1.039E+00 4.7056E-01 4.617084E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 9.411E-01 9.984E-01 1.001E+00 3.1145E-01 3.079587E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 9.272E-01 9.980E-01 9.732E-01 1.9043E-01 1.918833E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 9.136E-01 9.977E-01 9.503E-01 1.0766E-01 1.120254E-01 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 9.004E-01 9.973E-01 9.304E-01 5.6324E-02 6.145605E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 8.874E-01 9.969E-01 9.126E-01 2.7288E-02 3.176435E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 8.747E-01 9.965E-01 8.963E-01 1.2253E-02 1.550718E-02 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 8.622E-01 9.961E-01 8.811E-01 5.1023E-03 7.167533E-03 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 8.323E-01 9.951E-01 8.468E-01 4.1246E-04 8.312723E-04 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 8.040E-01 9.942E-01 8.163E-01 2.1119E-05 7.165276E-05 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 7.772E-01 9.932E-01 7.886E-01 6.9104E-07 4.717823E-06 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 7.517E-01 9.922E-01 7.632E-01 1.4569E-08 2.430347E-07 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 7.047E-01 9.903E-01 7.177E-01 1.7826E-12 3.351224E-10 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 6.622E-01 9.884E-01 6.780E-01 4.0713E-17 2.161695E-13 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 6.237E-01 9.864E-01 6.428E-01 1.8107E-22 7.286364E-17 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 4.017E+00 1.000E-01 9.8576E-01 9.8576E-01 9.8688E-01 3.7316E-01 3.7316E-01 3.7274E-01 3.7274E-01 3 4.042E+00 2.500E-01 9.6363E-01 9.6363E-01 9.6631E-01 3.8150E-01 3.8150E-01 3.8048E-01 3.8048E-01 4 4.083E+00 5.000E-01 9.2532E-01 9.2532E-01 9.3026E-01 3.9641E-01 3.9641E-01 3.9445E-01 3.9445E-01 5 4.167E+00 1.000E+00 8.4544E-01 8.4544E-01 8.5381E-01 4.2937E-01 4.2937E-01 4.2579E-01 4.2579E-01 6 4.250E+00 1.500E+00 7.6429E-01 7.6429E-01 7.7483E-01 4.6567E-01 4.6567E-01 4.6078E-01 4.6078E-01 7 4.333E+00 2.000E+00 6.8472E-01 6.8472E-01 6.9643E-01 5.0423E-01 5.0423E-01 4.9836E-01 4.9836E-01 8 4.500E+00 3.000E+00 5.3766E-01 5.3766E-01 5.4967E-01 5.8411E-01 5.8411E-01 5.7714E-01 5.7714E-01 9 4.667E+00 4.000E+00 4.1285E-01 4.1285E-01 4.2364E-01 6.6176E-01 6.6176E-01 6.5466E-01 6.5466E-01 10 4.833E+00 5.000E+00 3.1192E-01 3.1192E-01 3.2093E-01 7.3204E-01 7.3204E-01 7.2547E-01 7.2547E-01 11 5.000E+00 6.000E+00 2.3293E-01 2.3293E-01 2.4012E-01 7.9221E-01 7.9221E-01 7.8653E-01 7.8653E-01 12 5.167E+00 7.000E+00 1.7248E-01 1.7248E-01 1.7805E-01 8.4157E-01 8.4157E-01 8.3690E-01 8.3690E-01 13 5.333E+00 8.000E+00 1.2694E-01 1.2694E-01 1.3117E-01 8.8079E-01 8.8079E-01 8.7707E-01 8.7707E-01 14 5.500E+00 9.000E+00 9.3010E-02 9.3010E-02 9.6184E-02 9.1118E-01 9.1118E-01 9.0830E-01 9.0830E-01 15 5.667E+00 1.000E+01 6.7933E-02 6.7933E-02 7.0287E-02 9.3432E-01 9.3432E-01 9.3213E-01 9.3213E-01 16 6.083E+00 1.250E+01 3.0701E-02 3.0701E-02 3.1789E-02 9.6977E-01 9.6977E-01 9.6871E-01 9.6871E-01 17 6.500E+00 1.500E+01 1.3781E-02 1.3781E-02 1.4275E-02 9.8631E-01 9.8631E-01 9.8583E-01 9.8583E-01 18 6.917E+00 1.750E+01 6.1680E-03 6.1680E-03 6.3898E-03 9.9385E-01 9.9385E-01 9.9363E-01 9.9363E-01 19 7.333E+00 2.000E+01 2.7569E-03 2.7569E-03 2.8562E-03 9.9725E-01 9.9725E-01 9.9715E-01 9.9715E-01 20 8.167E+00 2.500E+01 5.4998E-04 5.4998E-04 5.6982E-04 9.9945E-01 9.9945E-01 9.9943E-01 9.9943E-01 21 9.000E+00 3.000E+01 1.0966E-04 1.0966E-04 1.1361E-04 9.9989E-01 9.9989E-01 9.9989E-01 9.9989E-01 22 9.833E+00 3.500E+01 2.1861E-05 2.1861E-05 2.2650E-05 9.9998E-01 9.9998E-01 9.9998E-01 9.9998E-01 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 4.000E+00 1.000E-01 9.8571E-01 9.8571E-01 9.8685E-01 3.7317E-01 3.7317E-01 3.7275E-01 3.7275E-01 25 4.000E+00 2.500E-01 9.6318E-01 9.6318E-01 9.6595E-01 3.8168E-01 3.8168E-01 3.8062E-01 3.8062E-01 26 4.000E+00 5.000E-01 9.2300E-01 9.2300E-01 9.2828E-01 3.9733E-01 3.9733E-01 3.9523E-01 3.9523E-01 27 4.001E+00 1.000E+00 8.3497E-01 8.3497E-01 8.4445E-01 4.3389E-01 4.3389E-01 4.2980E-01 4.2980E-01 28 4.001E+00 1.500E+00 7.4067E-01 7.4067E-01 7.5316E-01 4.7679E-01 4.7679E-01 4.7088E-01 4.7088E-01 29 4.001E+00 2.000E+00 6.4456E-01 6.4456E-01 6.5892E-01 5.2490E-01 5.2490E-01 5.1741E-01 5.1741E-01 30 4.002E+00 3.000E+00 4.6171E-01 4.6171E-01 4.7687E-01 6.3021E-01 6.3021E-01 6.2072E-01 6.2072E-01 31 4.003E+00 4.000E+00 3.0796E-01 3.0796E-01 3.2121E-01 7.3495E-01 7.3495E-01 7.2527E-01 7.2527E-01 32 4.003E+00 5.000E+00 1.9188E-01 1.9188E-01 2.0203E-01 8.2540E-01 8.2540E-01 8.1707E-01 8.1707E-01 33 4.004E+00 6.000E+00 1.1203E-01 1.1203E-01 1.1902E-01 8.9402E-01 8.9402E-01 8.8779E-01 8.8779E-01 34 4.005E+00 7.000E+00 6.1456E-02 6.1456E-02 6.5856E-02 9.4039E-01 9.4039E-01 9.3627E-01 9.3627E-01 35 4.006E+00 8.000E+00 3.1764E-02 3.1764E-02 3.4321E-02 9.6873E-01 9.6873E-01 9.6626E-01 9.6626E-01 36 4.006E+00 9.000E+00 1.5507E-02 1.5507E-02 1.6889E-02 9.8461E-01 9.8461E-01 9.8325E-01 9.8325E-01 37 4.007E+00 1.000E+01 7.1675E-03 7.1675E-03 7.8661E-03 9.9286E-01 9.9286E-01 9.9216E-01 9.9216E-01 38 4.009E+00 1.250E+01 8.3127E-04 8.3127E-04 9.2872E-04 9.9917E-01 9.9917E-01 9.9907E-01 9.9907E-01 39 4.010E+00 1.500E+01 7.1653E-05 7.1653E-05 8.1364E-05 9.9993E-01 9.9993E-01 9.9992E-01 9.9992E-01 40 4.012E+00 1.750E+01 4.7178E-06 4.7178E-06 5.4375E-06 1.0000E+00 1.0000E+00 9.9999E-01 9.9999E-01 41 4.014E+00 2.000E+01 2.4303E-07 2.4303E-07 2.8396E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 4.017E+00 2.500E+01 3.3512E-10 3.3512E-10 4.0114E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.021E+00 3.000E+01 2.1617E-13 2.1617E-13 2.6419E-13 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.024E+00 3.500E+01 7.2864E-17 7.2864E-17 9.0668E-17 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 4.000E-01 1.667E-02 0.0000E+00 1.0000E-01 0.0000E+00 2.5000E-01 3 1.000E+00 4.167E-02 0.0000E+00 2.5000E-01 0.0000E+00 2.5000E-01 4 2.000E+00 8.333E-02 0.0000E+00 5.0000E-01 0.0000E+00 2.5000E-01 5 4.000E+00 1.667E-01 0.0000E+00 1.0000E+00 0.0000E+00 2.5000E-01 6 6.000E+00 2.500E-01 0.0000E+00 1.5000E+00 0.0000E+00 2.5000E-01 7 8.000E+00 3.333E-01 0.0000E+00 2.0000E+00 0.0000E+00 2.5000E-01 8 1.200E+01 5.000E-01 0.0000E+00 3.0000E+00 0.0000E+00 2.5000E-01 9 1.600E+01 6.667E-01 0.0000E+00 4.0000E+00 0.0000E+00 2.5000E-01 10 2.000E+01 8.333E-01 0.0000E+00 5.0000E+00 0.0000E+00 2.5000E-01 11 2.400E+01 1.000E+00 0.0000E+00 6.0000E+00 0.0000E+00 2.5000E-01 12 2.800E+01 1.167E+00 0.0000E+00 7.0000E+00 0.0000E+00 2.5000E-01 13 3.200E+01 1.333E+00 0.0000E+00 8.0000E+00 0.0000E+00 2.5000E-01 14 3.600E+01 1.500E+00 0.0000E+00 9.0000E+00 0.0000E+00 2.5000E-01 15 4.000E+01 1.667E+00 0.0000E+00 1.0000E+01 0.0000E+00 2.5000E-01 16 5.000E+01 2.083E+00 0.0000E+00 1.2500E+01 0.0000E+00 2.5000E-01 17 6.000E+01 2.500E+00 0.0000E+00 1.5000E+01 0.0000E+00 2.5000E-01 18 7.000E+01 2.917E+00 0.0000E+00 1.7500E+01 0.0000E+00 2.5000E-01 19 8.000E+01 3.333E+00 0.0000E+00 2.0000E+01 0.0000E+00 2.5000E-01 20 1.000E+02 4.167E+00 0.0000E+00 2.5000E+01 0.0000E+00 2.5000E-01 21 1.200E+02 5.000E+00 0.0000E+00 3.0000E+01 0.0000E+00 2.5000E-01 22 1.400E+02 5.833E+00 0.0000E+00 3.5000E+01 0.0000E+00 2.5000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.667E-03 6.944E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E+01 25 4.167E-03 1.736E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E+01 26 8.333E-03 3.472E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E+01 27 1.667E-02 6.944E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E+01 28 2.500E-02 1.042E-03 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E+01 29 3.333E-02 1.389E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E+01 30 5.000E-02 2.083E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E+01 31 6.667E-02 2.778E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E+01 32 8.333E-02 3.472E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E+01 33 1.000E-01 4.167E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E+01 34 1.167E-01 4.861E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E+01 35 1.333E-01 5.556E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E+01 36 1.500E-01 6.250E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E+01 37 1.667E-01 6.944E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E+01 38 2.083E-01 8.681E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E+01 39 2.500E-01 1.042E-02 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E+01 40 2.917E-01 1.215E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E+01 41 3.333E-01 1.389E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E+01 42 4.167E-01 1.736E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E+01 43 5.000E-01 2.083E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E+01 44 5.833E-01 2.431E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 8.60000E-03 VC 2.00J 25-SEP-2003 11-NOV-2003 03:02:09 PM