VC 2.00J 25-SEP-2003 11-NOV-2003 09:24:23 AM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\bda\human\prostate\pc3\lpl\pc3.inp FNI: U:\bda\human\Prostate\pc3\lpl\pc3.inp FNO: U:\bda\human\Prostate\pc3\lpl\pc3.out RADX: U:\bda\human\Prostate\pc3\lpl\pc3.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- LPLM TABLE: Summary of LPL parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 RADIATION DAMAGE: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 1.14846E-11 7.05841E-03 40.000000 FL = 3.93160E-14 2.41636E-05 0.136935 DAMAGE REPAIR/MISREPAIR: A0= 9.500000E-01 (=95.000%) (1-A0)= 5.000000E-02 (=5.000%) RHT= 6.736513 h (=404.19 minute) LAM= 1.0289406E-01 (1/h) BMR= 1.9419944E-05 (1/h) LAM/BMR= 5.2983703E+03 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 0.136935 (1/Gy) beta = 0.037747 (1/Gy^2) alpha/beta = 3.627664 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 3.722E-04 1.389E-02 1.4267E-02 9.858347E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 2.278E-03 3.472E-02 3.6998E-02 9.636782E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 8.800E-03 6.939E-02 7.8192E-02 9.247872E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 3.291E-02 1.386E-01 1.7151E-01 8.423905E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 6.938E-02 2.077E-01 2.7705E-01 7.580135E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 1.158E-01 2.766E-01 3.9247E-01 6.753857E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 2.314E-01 4.143E-01 6.4571E-01 5.242909E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 3.683E-01 5.517E-01 9.2002E-01 3.985125E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 5.192E-01 6.889E-01 1.2081E+00 2.987707E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 6.791E-01 8.260E-01 1.5051E+00 2.219904E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 8.449E-01 9.631E-01 1.8080E+00 1.639777E-01 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 1.015E+00 1.100E+00 2.1148E+00 1.206627E-01 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 1.187E+00 1.237E+00 2.4240E+00 8.856788E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 1.361E+00 1.374E+00 2.7348E+00 6.490395E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 1.799E+00 1.716E+00 3.5159E+00 2.972148E-02 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 2.241E+00 2.059E+00 4.2994E+00 1.357666E-02 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 2.683E+00 2.401E+00 5.0838E+00 6.196473E-03 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 3.125E+00 2.744E+00 5.8684E+00 2.827278E-03 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 4.010E+00 3.428E+00 7.4380E+00 5.884549E-04 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 4.895E+00 4.113E+00 9.0076E+00 1.224702E-04 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 5.780E+00 4.798E+00 1.0577E+01 2.548852E-05 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 3.773E-04 1.390E-02 1.4276E-02 9.858256E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 2.356E-03 3.475E-02 3.7102E-02 9.635782E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.410E-03 6.949E-02 7.8900E-02 9.241326E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 3.754E-02 1.390E-01 1.7651E-01 8.381929E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 8.422E-02 2.084E-01 2.9267E-01 7.462712E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 1.493E-01 2.779E-01 4.2722E-01 6.523179E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 3.341E-01 4.168E-01 7.5092E-01 4.719304E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 5.907E-01 5.557E-01 1.1464E+00 3.177750E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 9.180E-01 6.945E-01 1.6125E+00 1.993849E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 1.315E+00 8.333E-01 2.1481E+00 1.167058E-01 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 1.780E+00 9.721E-01 2.7520E+00 6.379765E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 2.312E+00 1.111E+00 3.4232E+00 3.260649E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 2.911E+00 1.250E+00 4.1606E+00 1.559747E-02 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 3.575E+00 1.388E+00 4.9632E+00 6.990512E-03 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 5.513E+00 1.735E+00 7.2480E+00 7.116101E-04 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 7.837E+00 2.081E+00 9.9183E+00 4.926669E-05 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 1.053E+01 2.428E+00 1.2959E+01 2.353802E-06 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 1.358E+01 2.774E+00 1.6358E+01 7.868526E-08 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 2.071E+01 3.466E+00 2.4174E+01 3.172231E-11 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 2.911E+01 4.157E+00 3.3269E+01 3.558321E-15 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 3.871E+01 4.848E+00 4.3556E+01 1.212892E-19 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 4.017E+00 1.000E-01 2.500E-01 9.8583E-01 9.8583E-01 1.0000E+00 9.8583E-01 9.8583E-01 9.8603E-01 3 4.042E+00 2.500E-01 2.500E-01 9.6368E-01 9.6368E-01 1.0000E+00 9.6368E-01 9.6368E-01 9.6415E-01 4 4.083E+00 5.000E-01 2.500E-01 9.2479E-01 9.2479E-01 1.0000E+00 9.2479E-01 9.2479E-01 9.2564E-01 5 4.167E+00 1.000E+00 2.500E-01 8.4239E-01 8.4239E-01 1.0000E+00 8.4239E-01 8.4239E-01 8.4380E-01 6 4.250E+00 1.500E+00 2.500E-01 7.5801E-01 7.5801E-01 1.0000E+00 7.5801E-01 7.5801E-01 7.5974E-01 7 4.333E+00 2.000E+00 2.500E-01 6.7539E-01 6.7539E-01 1.0000E+00 6.7539E-01 6.7539E-01 6.7725E-01 8 4.500E+00 3.000E+00 2.500E-01 5.2429E-01 5.2429E-01 1.0000E+00 5.2429E-01 5.2429E-01 5.2611E-01 9 4.667E+00 4.000E+00 2.500E-01 3.9851E-01 3.9851E-01 1.0000E+00 3.9851E-01 3.9851E-01 4.0008E-01 10 4.833E+00 5.000E+00 2.500E-01 2.9877E-01 2.9877E-01 1.0000E+00 2.9877E-01 2.9877E-01 3.0004E-01 11 5.000E+00 6.000E+00 2.500E-01 2.2199E-01 2.2199E-01 1.0000E+00 2.2199E-01 2.2199E-01 2.2298E-01 12 5.167E+00 7.000E+00 2.500E-01 1.6398E-01 1.6398E-01 1.0000E+00 1.6398E-01 1.6398E-01 1.6473E-01 13 5.333E+00 8.000E+00 2.500E-01 1.2066E-01 1.2066E-01 1.0000E+00 1.2066E-01 1.2066E-01 1.2123E-01 14 5.500E+00 9.000E+00 2.500E-01 8.8568E-02 8.8568E-02 1.0000E+00 8.8568E-02 8.8568E-02 8.8986E-02 15 5.667E+00 1.000E+01 2.500E-01 6.4904E-02 6.4904E-02 1.0000E+00 6.4904E-02 6.4904E-02 6.5213E-02 16 6.083E+00 1.250E+01 2.500E-01 2.9721E-02 2.9721E-02 1.0000E+00 2.9721E-02 2.9721E-02 2.9864E-02 17 6.500E+00 1.500E+01 2.500E-01 1.3577E-02 1.3577E-02 1.0000E+00 1.3577E-02 1.3577E-02 1.3642E-02 18 6.917E+00 1.750E+01 2.500E-01 6.1965E-03 6.1965E-03 1.0000E+00 6.1965E-03 6.1965E-03 6.2263E-03 19 7.333E+00 2.000E+01 2.500E-01 2.8273E-03 2.8273E-03 1.0000E+00 2.8273E-03 2.8273E-03 2.8409E-03 20 8.167E+00 2.500E+01 2.500E-01 5.8845E-04 5.8845E-04 1.0000E+00 5.8845E-04 5.8845E-04 5.9129E-04 21 9.000E+00 3.000E+01 2.500E-01 1.2247E-04 1.2247E-04 1.0000E+00 1.2247E-04 1.2247E-04 1.2306E-04 22 9.833E+00 3.500E+01 2.500E-01 2.5489E-05 2.5489E-05 1.0000E+00 2.5489E-05 2.5489E-05 2.5611E-05 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 4.000E+00 1.000E-01 6.000E+01 9.8583E-01 9.8583E-01 1.0000E+00 9.8583E-01 9.8583E-01 9.8603E-01 25 4.000E+00 2.500E-01 6.000E+01 9.6358E-01 9.6358E-01 1.0000E+00 9.6358E-01 9.6358E-01 9.6407E-01 26 4.000E+00 5.000E-01 6.000E+01 9.2413E-01 9.2413E-01 1.0000E+00 9.2413E-01 9.2413E-01 9.2508E-01 27 4.001E+00 1.000E+00 6.000E+01 8.3819E-01 8.3819E-01 1.0000E+00 8.3819E-01 8.3819E-01 8.3990E-01 28 4.001E+00 1.500E+00 6.000E+01 7.4627E-01 7.4627E-01 1.0000E+00 7.4627E-01 7.4627E-01 7.4854E-01 29 4.001E+00 2.000E+00 6.000E+01 6.5232E-01 6.5232E-01 1.0000E+00 6.5232E-01 6.5232E-01 6.5496E-01 30 4.002E+00 3.000E+00 6.000E+01 4.7193E-01 4.7193E-01 1.0000E+00 4.7193E-01 4.7193E-01 4.7477E-01 31 4.003E+00 4.000E+00 6.000E+01 3.1777E-01 3.1777E-01 1.0000E+00 3.1777E-01 3.1777E-01 3.2031E-01 32 4.003E+00 5.000E+00 6.000E+01 1.9938E-01 1.9938E-01 1.0000E+00 1.9938E-01 1.9938E-01 2.0136E-01 33 4.004E+00 6.000E+00 6.000E+01 1.1671E-01 1.1671E-01 1.0000E+00 1.1671E-01 1.1671E-01 1.1808E-01 34 4.005E+00 7.000E+00 6.000E+01 6.3798E-02 6.3798E-02 1.0000E+00 6.3798E-02 6.3798E-02 6.4669E-02 35 4.006E+00 8.000E+00 6.000E+01 3.2606E-02 3.2606E-02 1.0000E+00 3.2606E-02 3.2606E-02 3.3112E-02 36 4.006E+00 9.000E+00 6.000E+01 1.5597E-02 1.5597E-02 1.0000E+00 1.5597E-02 1.5597E-02 1.5867E-02 37 4.007E+00 1.000E+01 6.000E+01 6.9905E-03 6.9905E-03 1.0000E+00 6.9905E-03 6.9905E-03 7.1240E-03 38 4.009E+00 1.250E+01 6.000E+01 7.1161E-04 7.1161E-04 1.0000E+00 7.1161E-04 7.1161E-04 7.2831E-04 39 4.010E+00 1.500E+01 6.000E+01 4.9267E-05 4.9267E-05 1.0000E+00 4.9267E-05 4.9267E-05 5.0631E-05 40 4.012E+00 1.750E+01 6.000E+01 2.3538E-06 2.3538E-06 1.0000E+00 2.3538E-06 2.3538E-06 2.4286E-06 41 4.014E+00 2.000E+01 6.000E+01 7.8685E-08 7.8685E-08 1.0000E+00 7.8685E-08 7.8685E-08 8.1494E-08 42 4.017E+00 2.500E+01 6.000E+01 3.1722E-11 3.1722E-11 1.0000E+00 3.1722E-11 3.1722E-11 3.3093E-11 43 4.021E+00 3.000E+01 6.000E+01 3.5583E-15 3.5583E-15 1.0000E+00 3.5583E-15 3.5583E-15 3.7370E-15 44 4.024E+00 3.500E+01 6.000E+01 1.2129E-19 1.2129E-19 1.0000E+00 1.2129E-19 1.2129E-19 1.2818E-19 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 2.500E-01 2.010E-01 0.00E+00 2.01032E-01 8.423E-07 8.423E-07 8.544E-07 3 2.500E-01 2.500E-01 5.064E-01 0.00E+00 5.06353E-01 2.074E-06 2.074E-06 2.152E-06 4 5.000E-01 2.500E-01 1.025E+00 0.00E+00 1.02459E+00 4.027E-06 4.027E-06 4.355E-06 5 1.000E+00 2.500E-01 2.092E+00 0.00E+00 2.09205E+00 7.490E-06 7.490E-06 8.891E-06 6 1.500E+00 2.500E-01 3.194E+00 0.00E+00 3.19414E+00 1.029E-05 1.029E-05 1.358E-05 7 2.000E+00 2.500E-01 4.324E+00 0.00E+00 4.32422E+00 1.241E-05 1.241E-05 1.838E-05 8 3.000E+00 2.500E-01 6.648E+00 0.00E+00 6.64783E+00 1.481E-05 1.481E-05 2.825E-05 9 4.000E+00 2.500E-01 9.031E+00 0.00E+00 9.03115E+00 1.530E-05 1.530E-05 3.838E-05 10 5.000E+00 2.500E-01 1.145E+01 0.00E+00 1.14534E+01 1.454E-05 1.454E-05 4.868E-05 11 6.000E+00 2.500E-01 1.390E+01 0.00E+00 1.39012E+01 1.311E-05 1.311E-05 5.908E-05 12 7.000E+00 2.500E-01 1.637E+01 0.00E+00 1.63655E+01 1.140E-05 1.140E-05 6.955E-05 13 8.000E+00 2.500E-01 1.884E+01 0.00E+00 1.88407E+01 9.661E-06 9.661E-06 8.007E-05 14 9.000E+00 2.500E-01 2.132E+01 0.00E+00 2.13230E+01 8.026E-06 8.026E-06 9.062E-05 15 1.000E+01 2.500E-01 2.381E+01 0.00E+00 2.38099E+01 6.567E-06 6.567E-06 1.012E-04 16 1.250E+01 2.500E-01 3.004E+01 0.00E+00 3.00381E+01 3.794E-06 3.794E-06 1.277E-04 17 1.500E+01 2.500E-01 3.627E+01 0.00E+00 3.62734E+01 2.093E-06 2.093E-06 1.541E-04 18 1.750E+01 2.500E-01 4.251E+01 0.00E+00 4.25110E+01 1.119E-06 1.119E-06 1.807E-04 19 2.000E+01 2.500E-01 4.875E+01 0.00E+00 4.87496E+01 5.857E-07 5.857E-07 2.072E-04 20 2.500E+01 2.500E-01 6.123E+01 0.00E+00 6.12273E+01 1.531E-07 1.531E-07 2.602E-04 21 3.000E+01 2.500E-01 7.371E+01 0.00E+00 7.37051E+01 3.836E-08 3.836E-08 3.132E-04 22 3.500E+01 2.500E-01 8.618E+01 0.00E+00 8.61830E+01 9.334E-09 9.334E-09 3.662E-04 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.000E+01 2.010E-01 0.00E+00 2.01046E-01 8.423E-07 8.423E-07 8.544E-07 25 2.500E-01 6.000E+01 5.066E-01 0.00E+00 5.06571E-01 2.075E-06 2.075E-06 2.153E-06 26 5.000E-01 6.000E+01 1.026E+00 0.00E+00 1.02630E+00 4.031E-06 4.031E-06 4.362E-06 27 1.000E+00 6.000E+01 2.105E+00 0.00E+00 2.10500E+00 7.499E-06 7.499E-06 8.946E-06 28 1.500E+00 6.000E+01 3.236E+00 0.00E+00 3.23568E+00 1.026E-05 1.026E-05 1.375E-05 29 2.000E+00 6.000E+01 4.418E+00 0.00E+00 4.41789E+00 1.225E-05 1.225E-05 1.878E-05 30 3.000E+00 6.000E+01 6.935E+00 0.00E+00 6.93522E+00 1.391E-05 1.391E-05 2.947E-05 31 4.000E+00 6.000E+01 9.654E+00 0.00E+00 9.65365E+00 1.304E-05 1.304E-05 4.103E-05 32 5.000E+00 6.000E+01 1.257E+01 0.00E+00 1.25699E+01 1.065E-05 1.065E-05 5.342E-05 33 6.000E+00 6.000E+01 1.568E+01 0.00E+00 1.56808E+01 7.777E-06 7.777E-06 6.664E-05 34 7.000E+00 6.000E+01 1.898E+01 0.00E+00 1.89831E+01 5.147E-06 5.147E-06 8.068E-05 35 8.000E+00 6.000E+01 2.247E+01 0.00E+00 2.24739E+01 3.114E-06 3.114E-06 9.551E-05 36 9.000E+00 6.000E+01 2.615E+01 0.00E+00 2.61501E+01 1.733E-06 1.733E-06 1.111E-04 37 1.000E+01 6.000E+01 3.001E+01 0.00E+00 3.00089E+01 8.915E-07 8.915E-07 1.275E-04 38 1.250E+01 6.000E+01 4.044E+01 0.00E+00 4.04355E+01 1.223E-07 1.223E-07 1.718E-04 39 1.500E+01 6.000E+01 5.194E+01 0.00E+00 5.19420E+01 1.087E-08 1.087E-08 2.207E-04 40 1.750E+01 6.000E+01 6.449E+01 0.00E+00 6.44876E+01 6.450E-10 6.450E-10 2.740E-04 41 2.000E+01 6.000E+01 7.803E+01 0.00E+00 7.80335E+01 2.609E-11 2.609E-11 3.316E-04 42 2.500E+01 6.000E+01 1.080E+02 0.00E+00 1.07981E+02 1.455E-14 1.455E-14 4.588E-04 43 3.000E+01 6.000E+01 1.415E+02 0.00E+00 1.41512E+02 2.139E-18 2.139E-18 6.012E-04 44 3.500E+01 6.000E+01 1.784E+02 0.00E+00 1.78380E+02 9.192E-23 9.192E-23 7.578E-04 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 2.500E-01 2.010E-01 8.423E-07 8.544E-07 6.8995E-05 6.9005E-05 6.8028E-05 3 2.500E-01 2.500E-01 5.064E-01 2.074E-06 2.152E-06 6.8995E-05 6.9021E-05 6.6514E-05 4 5.000E-01 2.500E-01 1.025E+00 4.027E-06 4.355E-06 6.8995E-05 6.9047E-05 6.3854E-05 5 1.000E+00 2.500E-01 2.092E+00 7.490E-06 8.891E-06 6.8995E-05 6.9101E-05 5.8210E-05 6 1.500E+00 2.500E-01 3.194E+00 1.029E-05 1.358E-05 6.8994E-05 6.9156E-05 5.2421E-05 7 2.000E+00 2.500E-01 4.324E+00 1.241E-05 1.838E-05 6.8994E-05 6.9213E-05 4.6746E-05 8 3.000E+00 2.500E-01 6.648E+00 1.481E-05 2.825E-05 6.8993E-05 6.9330E-05 3.6349E-05 9 4.000E+00 2.500E-01 9.031E+00 1.530E-05 3.838E-05 6.8993E-05 6.9450E-05 2.7677E-05 10 5.000E+00 2.500E-01 1.145E+01 1.454E-05 4.868E-05 6.8992E-05 6.9572E-05 2.0786E-05 11 6.000E+00 2.500E-01 1.390E+01 1.311E-05 5.908E-05 6.8991E-05 6.9696E-05 1.5472E-05 12 7.000E+00 2.500E-01 1.637E+01 1.140E-05 6.955E-05 6.8990E-05 6.9820E-05 1.1449E-05 13 8.000E+00 2.500E-01 1.884E+01 9.661E-06 8.007E-05 6.8990E-05 6.9945E-05 8.4397E-06 14 9.000E+00 2.500E-01 2.132E+01 8.026E-06 9.062E-05 6.8989E-05 7.0070E-05 6.2059E-06 15 1.000E+01 2.500E-01 2.381E+01 6.567E-06 1.012E-04 6.8988E-05 7.0195E-05 4.5559E-06 16 1.250E+01 2.500E-01 3.004E+01 3.794E-06 1.277E-04 6.8986E-05 7.0509E-05 2.0956E-06 17 1.500E+01 2.500E-01 3.627E+01 2.093E-06 1.541E-04 6.8985E-05 7.0823E-05 9.6154E-07 18 1.750E+01 2.500E-01 4.251E+01 1.119E-06 1.807E-04 6.8983E-05 7.1138E-05 4.4080E-07 19 2.000E+01 2.500E-01 4.875E+01 5.857E-07 2.072E-04 6.8981E-05 7.1452E-05 2.0201E-07 20 2.500E+01 2.500E-01 6.123E+01 1.531E-07 2.602E-04 6.8977E-05 7.2081E-05 4.2416E-08 21 3.000E+01 2.500E-01 7.371E+01 3.836E-08 3.132E-04 6.8974E-05 7.2710E-05 8.9048E-09 22 3.500E+01 2.500E-01 8.618E+01 9.334E-09 3.662E-04 6.8970E-05 7.3338E-05 1.8693E-09 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.000E+01 2.010E-01 8.423E-07 8.544E-07 6.8995E-05 6.9005E-05 6.8027E-05 25 2.500E-01 6.000E+01 5.066E-01 2.075E-06 2.153E-06 6.8995E-05 6.9021E-05 6.6507E-05 26 5.000E-01 6.000E+01 1.026E+00 4.031E-06 4.362E-06 6.8995E-05 6.9047E-05 6.3809E-05 27 1.000E+00 6.000E+01 2.105E+00 7.499E-06 8.946E-06 6.8995E-05 6.9101E-05 5.7920E-05 28 1.500E+00 6.000E+01 3.236E+00 1.026E-05 1.375E-05 6.8994E-05 6.9158E-05 5.1611E-05 29 2.000E+00 6.000E+01 4.418E+00 1.225E-05 1.878E-05 6.8994E-05 6.9218E-05 4.5152E-05 30 3.000E+00 6.000E+01 6.935E+00 1.391E-05 2.947E-05 6.8993E-05 6.9345E-05 3.2726E-05 31 4.000E+00 6.000E+01 9.654E+00 1.304E-05 4.103E-05 6.8992E-05 6.9482E-05 2.2080E-05 32 5.000E+00 6.000E+01 1.257E+01 1.065E-05 5.342E-05 6.8992E-05 6.9629E-05 1.3883E-05 33 6.000E+00 6.000E+01 1.568E+01 7.777E-06 6.664E-05 6.8991E-05 6.9786E-05 8.1444E-06 34 7.000E+00 6.000E+01 1.898E+01 5.147E-06 8.068E-05 6.8990E-05 6.9952E-05 4.4628E-06 35 8.000E+00 6.000E+01 2.247E+01 3.114E-06 9.551E-05 6.8989E-05 7.0128E-05 2.2866E-06 36 9.000E+00 6.000E+01 2.615E+01 1.733E-06 1.111E-04 6.8988E-05 7.0313E-05 1.0967E-06 37 1.000E+01 6.000E+01 3.001E+01 8.915E-07 1.275E-04 6.8986E-05 7.0508E-05 4.9288E-07 38 1.250E+01 6.000E+01 4.044E+01 1.223E-07 1.718E-04 6.8983E-05 7.1033E-05 5.0548E-08 39 1.500E+01 6.000E+01 5.194E+01 1.087E-08 2.207E-04 6.8980E-05 7.1613E-05 3.5281E-09 40 1.750E+01 6.000E+01 6.449E+01 6.450E-10 2.740E-04 6.8976E-05 7.2245E-05 1.7005E-10 41 2.000E+01 6.000E+01 7.803E+01 2.609E-11 3.316E-04 6.8972E-05 7.2928E-05 5.7383E-12 42 2.500E+01 6.000E+01 1.080E+02 1.455E-14 4.588E-04 6.8964E-05 7.4436E-05 2.3613E-15 43 3.000E+01 6.000E+01 1.415E+02 2.139E-18 6.012E-04 6.8954E-05 7.6126E-05 2.7088E-19 44 3.500E+01 6.000E+01 1.784E+02 9.192E-23 7.578E-04 6.8943E-05 7.7983E-05 9.4584E-24 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency LPLM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.137 (1/Gy), alpha/beta = 3.628 (Gy), lamda = 1.029E-01 (1/h). ====================================================================================================== --- Duration (h) --- Dose Dose Rate* ***** G FACTOR ***** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL GEFF SF1 SF2 ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 9.864E-01 1.518E+00 9.8603E-01 9.858347E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 9.666E-01 1.172E+00 9.6414E-01 9.636782E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 9.348E-01 1.030E+00 9.2562E-01 9.247872E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 8.758E-01 9.160E-01 8.4367E-01 8.423905E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 8.224E-01 8.436E-01 7.5938E-01 7.580135E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 7.739E-01 7.855E-01 6.7657E-01 6.753857E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 6.896E-01 6.914E-01 5.2463E-01 5.242909E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 6.192E-01 6.164E-01 3.9785E-01 3.985125E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 5.599E-01 5.546E-01 2.9728E-01 2.987707E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 5.097E-01 5.030E-01 2.1998E-01 2.219904E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 4.668E-01 4.593E-01 1.6172E-01 1.639777E-01 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 4.298E-01 4.219E-01 1.1839E-01 1.206627E-01 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 3.978E-01 3.897E-01 8.6417E-02 8.856788E-02 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 3.698E-01 3.617E-01 6.2961E-02 6.490395E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 3.136E-01 3.059E-01 2.8397E-02 2.972148E-02 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 2.716E-01 2.644E-01 1.2769E-02 1.357666E-02 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 2.392E-01 2.325E-01 5.7358E-03 6.196473E-03 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 2.135E-01 2.073E-01 2.5755E-03 2.827278E-03 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 1.755E-01 1.702E-01 5.1909E-04 5.884549E-04 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 1.489E-01 1.442E-01 1.0461E-04 1.224702E-04 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 1.292E-01 1.251E-01 2.1083E-05 2.548852E-05 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 9.999E-01 1.543E+00 9.8603E-01 9.858256E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 9.999E-01 1.216E+00 9.6407E-01 9.635782E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.997E-01 1.105E+00 9.2506E-01 9.241326E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 9.994E-01 1.048E+00 8.3974E-01 8.381929E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 9.991E-01 1.027E+00 7.4807E-01 7.462712E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.989E-01 1.016E+00 6.5397E-01 6.523179E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 9.983E-01 1.001E+00 4.7239E-01 4.719304E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 9.977E-01 9.912E-01 3.1654E-01 3.177750E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 9.971E-01 9.832E-01 1.9678E-01 1.993849E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 9.966E-01 9.761E-01 1.1351E-01 1.167058E-01 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 9.960E-01 9.697E-01 6.0762E-02 6.379765E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 9.954E-01 9.635E-01 3.0188E-02 3.260649E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 9.949E-01 9.577E-01 1.3922E-02 1.559747E-02 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 9.943E-01 9.521E-01 5.9604E-03 6.990512E-03 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 9.929E-01 9.387E-01 5.1682E-04 7.116101E-04 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 9.915E-01 9.259E-01 2.8238E-05 4.926669E-05 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 9.901E-01 9.138E-01 9.7411E-07 2.353802E-06 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 9.887E-01 9.020E-01 2.1258E-08 7.868526E-08 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 9.859E-01 8.796E-01 2.5833E-12 3.172231E-11 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 9.831E-01 8.584E-01 5.1467E-17 3.558321E-15 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 9.803E-01 8.383E-01 1.7073E-22 1.212892E-19 ------------------------------------------------------------------------------------------------------ GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/D)/(beta*D). In the formula for GEFF, SF is surviving fraction as computed using the LPL model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL. The SF estimates are: SF1=EXP{-dose*[alpha+gl*beta*dose]} and SF2=EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 4.017E+00 1.000E-01 9.8583E-01 9.8583E-01 9.8603E-01 3.7313E-01 3.7313E-01 3.7305E-01 3.7305E-01 3 4.042E+00 2.500E-01 9.6368E-01 9.6368E-01 9.6415E-01 3.8149E-01 3.8149E-01 3.8131E-01 3.8131E-01 4 4.083E+00 5.000E-01 9.2479E-01 9.2479E-01 9.2564E-01 3.9662E-01 3.9662E-01 3.9628E-01 3.9628E-01 5 4.167E+00 1.000E+00 8.4239E-01 8.4239E-01 8.4380E-01 4.3068E-01 4.3068E-01 4.3007E-01 4.3007E-01 6 4.250E+00 1.500E+00 7.5801E-01 7.5801E-01 7.5974E-01 4.6860E-01 4.6860E-01 4.6779E-01 4.6779E-01 7 4.333E+00 2.000E+00 6.7539E-01 6.7539E-01 6.7725E-01 5.0896E-01 5.0896E-01 5.0801E-01 5.0801E-01 8 4.500E+00 3.000E+00 5.2429E-01 5.2429E-01 5.2611E-01 5.9198E-01 5.9198E-01 5.9090E-01 5.9090E-01 9 4.667E+00 4.000E+00 3.9851E-01 3.9851E-01 4.0008E-01 6.7132E-01 6.7132E-01 6.7026E-01 6.7026E-01 10 4.833E+00 5.000E+00 2.9877E-01 2.9877E-01 3.0004E-01 7.4173E-01 7.4173E-01 7.4079E-01 7.4079E-01 11 5.000E+00 6.000E+00 2.2199E-01 2.2199E-01 2.2298E-01 8.0092E-01 8.0092E-01 8.0013E-01 8.0013E-01 12 5.167E+00 7.000E+00 1.6398E-01 1.6398E-01 1.6473E-01 8.4876E-01 8.4876E-01 8.4812E-01 8.4812E-01 13 5.333E+00 8.000E+00 1.2066E-01 1.2066E-01 1.2123E-01 8.8633E-01 8.8633E-01 8.8583E-01 8.8583E-01 14 5.500E+00 9.000E+00 8.8568E-02 8.8568E-02 8.8986E-02 9.1524E-01 9.1524E-01 9.1486E-01 9.1486E-01 15 5.667E+00 1.000E+01 6.4904E-02 6.4904E-02 6.5213E-02 9.3716E-01 9.3716E-01 9.3687E-01 9.3687E-01 16 6.083E+00 1.250E+01 2.9721E-02 2.9721E-02 2.9864E-02 9.7072E-01 9.7072E-01 9.7058E-01 9.7058E-01 17 6.500E+00 1.500E+01 1.3577E-02 1.3577E-02 1.3642E-02 9.8652E-01 9.8652E-01 9.8645E-01 9.8645E-01 18 6.917E+00 1.750E+01 6.1965E-03 6.1965E-03 6.2263E-03 9.9382E-01 9.9382E-01 9.9379E-01 9.9379E-01 19 7.333E+00 2.000E+01 2.8273E-03 2.8273E-03 2.8409E-03 9.9718E-01 9.9718E-01 9.9716E-01 9.9716E-01 20 8.167E+00 2.500E+01 5.8845E-04 5.8845E-04 5.9129E-04 9.9941E-01 9.9941E-01 9.9941E-01 9.9941E-01 21 9.000E+00 3.000E+01 1.2247E-04 1.2247E-04 1.2306E-04 9.9988E-01 9.9988E-01 9.9988E-01 9.9988E-01 22 9.833E+00 3.500E+01 2.5489E-05 2.5489E-05 2.5611E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 4.000E+00 1.000E-01 9.8583E-01 9.8583E-01 9.8603E-01 3.7313E-01 3.7313E-01 3.7306E-01 3.7306E-01 25 4.000E+00 2.500E-01 9.6358E-01 9.6358E-01 9.6407E-01 3.8153E-01 3.8153E-01 3.8134E-01 3.8134E-01 26 4.000E+00 5.000E-01 9.2413E-01 9.2413E-01 9.2508E-01 3.9688E-01 3.9688E-01 3.9650E-01 3.9650E-01 27 4.001E+00 1.000E+00 8.3819E-01 8.3819E-01 8.3990E-01 4.3249E-01 4.3249E-01 4.3175E-01 4.3175E-01 28 4.001E+00 1.500E+00 7.4627E-01 7.4627E-01 7.4854E-01 4.7413E-01 4.7413E-01 4.7306E-01 4.7306E-01 29 4.001E+00 2.000E+00 6.5232E-01 6.5232E-01 6.5496E-01 5.2084E-01 5.2084E-01 5.1946E-01 5.1946E-01 30 4.002E+00 3.000E+00 4.7193E-01 4.7193E-01 4.7477E-01 6.2380E-01 6.2380E-01 6.2203E-01 6.2203E-01 31 4.003E+00 4.000E+00 3.1777E-01 3.1777E-01 3.2031E-01 7.2777E-01 7.2777E-01 7.2593E-01 7.2593E-01 32 4.003E+00 5.000E+00 1.9938E-01 1.9938E-01 2.0136E-01 8.1923E-01 8.1923E-01 8.1762E-01 8.1762E-01 33 4.004E+00 6.000E+00 1.1671E-01 1.1671E-01 1.1808E-01 8.8985E-01 8.8985E-01 8.8862E-01 8.8862E-01 34 4.005E+00 7.000E+00 6.3798E-02 6.3798E-02 6.4669E-02 9.3819E-01 9.3819E-01 9.3738E-01 9.3738E-01 35 4.006E+00 8.000E+00 3.2606E-02 3.2606E-02 3.3112E-02 9.6792E-01 9.6792E-01 9.6743E-01 9.6743E-01 36 4.006E+00 9.000E+00 1.5597E-02 1.5597E-02 1.5867E-02 9.8452E-01 9.8452E-01 9.8426E-01 9.8426E-01 37 4.007E+00 1.000E+01 6.9905E-03 6.9905E-03 7.1240E-03 9.9303E-01 9.9303E-01 9.9290E-01 9.9290E-01 38 4.009E+00 1.250E+01 7.1161E-04 7.1161E-04 7.2831E-04 9.9929E-01 9.9929E-01 9.9927E-01 9.9927E-01 39 4.010E+00 1.500E+01 4.9267E-05 4.9267E-05 5.0631E-05 9.9995E-01 9.9995E-01 9.9995E-01 9.9995E-01 40 4.012E+00 1.750E+01 2.3538E-06 2.3538E-06 2.4286E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 4.014E+00 2.000E+01 7.8685E-08 7.8685E-08 8.1494E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 4.017E+00 2.500E+01 3.1722E-11 3.1722E-11 3.3093E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.021E+00 3.000E+01 3.5583E-15 3.5583E-15 3.7370E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.024E+00 3.500E+01 1.2129E-19 1.2129E-19 1.2818E-19 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 4.000E-01 1.667E-02 0.0000E+00 1.0000E-01 0.0000E+00 2.5000E-01 3 1.000E+00 4.167E-02 0.0000E+00 2.5000E-01 0.0000E+00 2.5000E-01 4 2.000E+00 8.333E-02 0.0000E+00 5.0000E-01 0.0000E+00 2.5000E-01 5 4.000E+00 1.667E-01 0.0000E+00 1.0000E+00 0.0000E+00 2.5000E-01 6 6.000E+00 2.500E-01 0.0000E+00 1.5000E+00 0.0000E+00 2.5000E-01 7 8.000E+00 3.333E-01 0.0000E+00 2.0000E+00 0.0000E+00 2.5000E-01 8 1.200E+01 5.000E-01 0.0000E+00 3.0000E+00 0.0000E+00 2.5000E-01 9 1.600E+01 6.667E-01 0.0000E+00 4.0000E+00 0.0000E+00 2.5000E-01 10 2.000E+01 8.333E-01 0.0000E+00 5.0000E+00 0.0000E+00 2.5000E-01 11 2.400E+01 1.000E+00 0.0000E+00 6.0000E+00 0.0000E+00 2.5000E-01 12 2.800E+01 1.167E+00 0.0000E+00 7.0000E+00 0.0000E+00 2.5000E-01 13 3.200E+01 1.333E+00 0.0000E+00 8.0000E+00 0.0000E+00 2.5000E-01 14 3.600E+01 1.500E+00 0.0000E+00 9.0000E+00 0.0000E+00 2.5000E-01 15 4.000E+01 1.667E+00 0.0000E+00 1.0000E+01 0.0000E+00 2.5000E-01 16 5.000E+01 2.083E+00 0.0000E+00 1.2500E+01 0.0000E+00 2.5000E-01 17 6.000E+01 2.500E+00 0.0000E+00 1.5000E+01 0.0000E+00 2.5000E-01 18 7.000E+01 2.917E+00 0.0000E+00 1.7500E+01 0.0000E+00 2.5000E-01 19 8.000E+01 3.333E+00 0.0000E+00 2.0000E+01 0.0000E+00 2.5000E-01 20 1.000E+02 4.167E+00 0.0000E+00 2.5000E+01 0.0000E+00 2.5000E-01 21 1.200E+02 5.000E+00 0.0000E+00 3.0000E+01 0.0000E+00 2.5000E-01 22 1.400E+02 5.833E+00 0.0000E+00 3.5000E+01 0.0000E+00 2.5000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.667E-03 6.944E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E+01 25 4.167E-03 1.736E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E+01 26 8.333E-03 3.472E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E+01 27 1.667E-02 6.944E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E+01 28 2.500E-02 1.042E-03 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E+01 29 3.333E-02 1.389E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E+01 30 5.000E-02 2.083E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E+01 31 6.667E-02 2.778E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E+01 32 8.333E-02 3.472E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E+01 33 1.000E-01 4.167E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E+01 34 1.167E-01 4.861E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E+01 35 1.333E-01 5.556E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E+01 36 1.500E-01 6.250E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E+01 37 1.667E-01 6.944E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E+01 38 2.083E-01 8.681E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E+01 39 2.500E-01 1.042E-02 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E+01 40 2.917E-01 1.215E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E+01 41 3.333E-01 1.389E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E+01 42 4.167E-01 1.736E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E+01 43 5.000E-01 2.083E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E+01 44 5.833E-01 2.431E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 6.25000E-03 VC 2.00J 25-SEP-2003 11-NOV-2003 09:24:23 AM