VC 2.00J 25-SEP-2003 11-NOV-2003 03:00:27 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\pc3.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\pc3.radx (8 exposures) XDAT: ..\xdat\pc3.xdat (8 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 1.5520561E-04 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 3.2075369E-03 2202 CLRP RHT 1.00000E-03 2.40000E+01 8.00000E+00 9.8389317E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 1.39472E-02 (nfom=347, nsim=2776, nmx=8, nox=8, ndf=4, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-1.754E-01 max=1.458E-01, mean=-5.0784E-03, stdev=1.1916E-01, var=1.4199E-02 Student's T test (mean=0, NDF=4): Pr>ABS(0.12054)= 9.0986E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.92457)=4.729E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-6.203E-02 max=5.154E-02, mean=-1.7955E-03, stdev=4.2129E-02, var=1.7748E-03 Student's T test (mean=0, NDF=4): Pr>ABS(0.12054)= 9.0986E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.92457)=4.729E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 3.207537E-03 (=0.321%) PHI2= 3.207537E-03 (=0.321%) (1-A1)*PHI1= 3.207537E-03 (=0.321%) (1-A2)*PHI2= 3.207537E-03 (=0.321%) (1-A1)*(1-PHI1)= 9.967925E-01 (=99.679%) (1-A2)*(1-PHI2)= 9.967925E-01 (=99.679%) RHT1= 0.250000 h (=15.00 minute) RHT2= 9.838932 h (=590.34 minute) LAM1= 2.7725887E+00 (1/h) LAM2= 7.0449435E-02 (1/h) BMR= 1.5520561E-04 (1/h) LAM1/BMR= 1.7863972E+04 LAM2/BMR= 4.5391036E+02 (LAM1+LAM2)/BMR= 1.8317882E+04 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 9.6226E-02 + 3.2075E-02 = 1.2830148E-01 (1/Gy) beta: 1.0259E-02 + 3.1227E-02 = 4.1485604E-02 (1/Gy^2) alpha/beta: 3.0926747 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (PC3 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 2.4000E+01 6.0000E+00 2.5000E-01 2.08547E-01 1.25E-01 2.32932E-01 1.0469E-01 2 4.7752E+01 1.1938E+01 2.5000E-01 3.13760E-02 1.25E-01 3.67306E-02 1.4578E-01 3 7.1572E+01 1.7893E+01 2.5000E-01 5.80823E-03 1.25E-01 5.43495E-03 -6.8681E-02 4 3.3588E-02 2.0153E+00 6.0000E+01 7.15134E-01 1.25E-01 6.41630E-01 -1.1456E-01 5 6.6543E-02 3.9926E+00 6.0000E+01 3.63164E-01 1.25E-01 3.08961E-01 -1.7543E-01 6 9.9663E-02 5.9798E+00 6.0000E+01 1.15640E-01 1.25E-01 1.13321E-01 -2.0466E-02 7 1.3269E-01 7.9612E+00 6.0000E+01 2.84121E-02 1.25E-01 3.26235E-02 1.2909E-01 8 1.6589E-01 9.9535E+00 6.0000E+01 7.74348E-03 1.25E-01 7.43819E-03 -4.1044E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-1.754E-01 max=1.458E-01, mean=-5.0784E-03, stdev=1.1916E-01, var=1.4199E-02 Student's T test (mean=0, NDF=4): Pr>ABS(0.12054)= 9.0986E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.92457)=4.729E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-6.203E-02 max=5.154E-02, mean=-1.7955E-03, stdev=4.2129E-02, var=1.7748E-03 Student's T test (mean=0, NDF=4): Pr>ABS(0.12054)= 9.0986E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.92457)=4.729E-01 (passed normality test) NOX=8, NPAR=3 CFE.SF: Cell survival data for PC3 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 2.4000E+01 6.0000E+00 2.5000E-01 7.91453E-01 2.08547E-01 1.00E+01 2 2 4.7752E+01 1.1938E+01 2.5000E-01 9.68624E-01 3.13760E-02 1.00E+01 3 3 7.1572E+01 1.7893E+01 2.5000E-01 9.94192E-01 5.80823E-03 1.00E+01 4 4 3.3588E-02 2.0153E+00 6.0000E+01 2.84866E-01 7.15134E-01 1.00E+01 5 5 6.6543E-02 3.9926E+00 6.0000E+01 6.36836E-01 3.63164E-01 1.00E+01 6 6 9.9663E-02 5.9798E+00 6.0000E+01 8.84360E-01 1.15640E-01 1.00E+01 7 7 1.3269E-01 7.9612E+00 6.0000E+01 9.71588E-01 2.84121E-02 1.00E+01 8 8 1.6589E-01 9.9535E+00 6.0000E+01 9.92257E-01 7.74348E-03 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (PC3). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 2.400E+01 1.200E+01 4.000E+02 6.0000E+00 2.6127E-01 1.5676E+00 2 2 4.775E+01 1.200E+01 4.000E+02 1.1938E+01 2.8997E-01 3.4617E+00 3 3 7.157E+01 1.200E+01 4.000E+02 1.7893E+01 2.8774E-01 5.1485E+00 4 4 3.359E-02 1.200E+01 4.000E+02 2.0153E+00 1.6637E-01 3.3529E-01 5 5 6.654E-02 1.200E+01 4.000E+02 3.9926E+00 2.5369E-01 1.0129E+00 6 6 9.966E-02 1.200E+01 4.000E+02 5.9798E+00 3.6076E-01 2.1573E+00 7 7 1.327E-01 1.200E+01 4.000E+02 7.9612E+00 4.4729E-01 3.5609E+00 8 8 1.659E-01 1.200E+01 4.000E+02 9.9535E+00 4.8836E-01 4.8609E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.30470 VC 2.00J 25-SEP-2003 11-NOV-2003 03:00:45 PM