VC 2.00J 25-SEP-2003 20-NOV-2003 06:41:16 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: c:\kbem\bin\vc.exe c:\kbem\archive\human\prostate\du145b\tlk\du145.inp FNI: C:\KBEM\archive\human\Prostate\du145b\tlk\du145.inp FNO: C:\KBEM\archive\human\Prostate\du145b\tlk\du145.out RADX: C:\KBEM\archive\human\Prostate\du145b\tlk\du145.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 1.43557E-12 8.82301E-04 5.000000 Total DSB = 1.00490E-11 6.17611E-03 35.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 4.060298E-03 (=0.406%) PHI2= 4.060298E-03 (=0.406%) (1-A1)*PHI1= 4.060298E-03 (=0.406%) (1-A2)*PHI2= 4.060298E-03 (=0.406%) (1-A1)*(1-PHI1)= 9.959397E-01 (=99.594%) (1-A2)*(1-PHI2)= 9.959397E-01 (=99.594%) RHT1= 0.250000 h (=15.00 minute) RHT2= 13.286850 h (=797.21 minute) LAM1= 2.7725887E+00 (1/h) LAM2= 5.2167909E-02 (1/h) BMR= 2.2304598E-04 (1/h) LAM1/BMR= 1.2430570E+04 LAM2/BMR= 2.3388859E+02 (LAM1+LAM2)/BMR= 1.2664459E+04 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.2181E-01 + 2.0301E-02 = 1.4211043E-01 (1/Gy) beta: 1.1816E-02 + 1.6057E-02 = 2.7873247E-02 (1/Gy^2) alpha/beta: 5.0984526 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 1.444E-02 3.299E-03 1.7741E-02 9.824158E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 3.683E-02 8.094E-03 4.4924E-02 9.560703E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 7.572E-02 1.569E-02 9.1406E-02 9.126469E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 1.587E-01 2.952E-02 1.8824E-01 8.284200E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 2.480E-01 4.170E-02 2.8969E-01 7.484974E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 3.428E-01 5.244E-02 3.9522E-01 6.735293E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 5.464E-01 7.025E-02 6.1670E-01 5.397242E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 7.654E-01 8.411E-02 8.4947E-01 4.276416E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 9.962E-01 9.488E-02 1.0911E+00 3.358621E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 1.236E+00 1.033E-01 1.3395E+00 2.619738E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 1.484E+00 1.098E-01 1.5933E+00 2.032491E-01 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 1.736E+00 1.149E-01 1.8513E+00 1.570312E-01 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 1.994E+00 1.188E-01 2.1126E+00 1.209290E-01 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 2.254E+00 1.219E-01 2.3763E+00 9.289097E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 2.917E+00 1.269E-01 3.0435E+00 4.766836E-02 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 3.588E+00 1.296E-01 3.7174E+00 2.429598E-02 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 4.264E+00 1.311E-01 4.3950E+00 1.233835E-02 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 4.943E+00 1.319E-01 5.0746E+00 6.253634E-03 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 6.304E+00 1.325E-01 6.4363E+00 1.602259E-03 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 7.667E+00 1.327E-01 7.7994E+00 4.099776E-04 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 9.030E+00 1.327E-01 9.1629E+00 1.048632E-04 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 1.448E-02 3.334E-03 1.7809E-02 9.823482E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 3.723E-02 8.304E-03 4.5533E-02 9.554881E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 7.790E-02 1.651E-02 9.4408E-02 9.099116E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 1.694E-01 3.263E-02 2.0202E-01 8.170796E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 2.741E-01 4.838E-02 3.2251E-01 7.243283E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 3.918E-01 6.377E-02 4.5557E-01 6.340859E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 6.647E-01 9.351E-02 7.5820E-01 4.685101E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 9.857E-01 1.219E-01 1.1076E+00 3.303530E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 1.352E+00 1.492E-01 1.5016E+00 2.227749E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 1.763E+00 1.752E-01 1.9382E+00 1.439681E-01 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 2.215E+00 2.003E-01 2.4154E+00 8.933255E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 2.707E+00 2.243E-01 2.9315E+00 5.331865E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 3.237E+00 2.473E-01 3.4847E+00 3.066281E-02 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 3.804E+00 2.695E-01 4.0735E+00 1.701782E-02 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 5.370E+00 3.214E-01 5.6913E+00 3.375190E-03 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 7.132E+00 3.688E-01 7.5007E+00 5.527133E-04 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 9.071E+00 4.121E-01 9.4829E+00 7.614017E-05 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 1.117E+01 4.520E-01 1.1622E+01 8.968565E-06 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 1.579E+01 5.229E-01 1.6314E+01 8.222930E-08 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 2.090E+01 5.840E-01 2.1481E+01 4.685488E-10 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 2.641E+01 6.371E-01 2.7050E+01 1.787597E-12 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 4.017E+00 1.000E-01 2.500E-01 9.8242E-01 9.8242E-01 1.0000E+00 9.8242E-01 9.8242E-01 9.8566E-01 3 4.042E+00 2.500E-01 2.500E-01 9.5607E-01 9.5607E-01 1.0000E+00 9.5607E-01 9.5607E-01 9.6384E-01 4 4.083E+00 5.000E-01 2.500E-01 9.1265E-01 9.1265E-01 1.0000E+00 9.1265E-01 9.1265E-01 9.2708E-01 5 4.167E+00 1.000E+00 2.500E-01 8.2842E-01 8.2842E-01 1.0000E+00 8.2842E-01 8.2842E-01 8.5324E-01 6 4.250E+00 1.500E+00 2.500E-01 7.4850E-01 7.4850E-01 1.0000E+00 7.4850E-01 7.4850E-01 7.8037E-01 7 4.333E+00 2.000E+00 2.500E-01 6.7353E-01 6.7353E-01 1.0000E+00 6.7353E-01 6.7353E-01 7.0979E-01 8 4.500E+00 3.000E+00 2.500E-01 5.3972E-01 5.3972E-01 1.0000E+00 5.3972E-01 5.3972E-01 5.7901E-01 9 4.667E+00 4.000E+00 2.500E-01 4.2764E-01 4.2764E-01 1.0000E+00 4.2764E-01 4.2764E-01 4.6517E-01 10 4.833E+00 5.000E+00 2.500E-01 3.3586E-01 3.3586E-01 1.0000E+00 3.3586E-01 3.3586E-01 3.6929E-01 11 5.000E+00 6.000E+00 2.500E-01 2.6197E-01 2.6197E-01 1.0000E+00 2.6197E-01 2.6197E-01 2.9047E-01 12 5.167E+00 7.000E+00 2.500E-01 2.0325E-01 2.0325E-01 1.0000E+00 2.0325E-01 2.0325E-01 2.2684E-01 13 5.333E+00 8.000E+00 2.500E-01 1.5703E-01 1.5703E-01 1.0000E+00 1.5703E-01 1.5703E-01 1.7615E-01 14 5.500E+00 9.000E+00 2.500E-01 1.2093E-01 1.2093E-01 1.0000E+00 1.2093E-01 1.2093E-01 1.3619E-01 15 5.667E+00 1.000E+01 2.500E-01 9.2891E-02 9.2891E-02 1.0000E+00 9.2891E-02 9.2891E-02 1.0493E-01 16 6.083E+00 1.250E+01 2.500E-01 4.7668E-02 4.7668E-02 1.0000E+00 4.7668E-02 4.7668E-02 5.4121E-02 17 6.500E+00 1.500E+01 2.500E-01 2.4296E-02 2.4296E-02 1.0000E+00 2.4296E-02 2.4296E-02 2.7659E-02 18 6.917E+00 1.750E+01 2.500E-01 1.2338E-02 1.2338E-02 1.0000E+00 1.2338E-02 1.2338E-02 1.4067E-02 19 7.333E+00 2.000E+01 2.500E-01 6.2536E-03 6.2536E-03 1.0000E+00 6.2536E-03 6.2536E-03 7.1351E-03 20 8.167E+00 2.500E+01 2.500E-01 1.6023E-03 1.6023E-03 1.0000E+00 1.6023E-03 1.6023E-03 1.8293E-03 21 9.000E+00 3.000E+01 2.500E-01 4.0998E-04 4.0998E-04 1.0000E+00 4.0998E-04 4.0998E-04 4.6815E-04 22 9.833E+00 3.500E+01 2.500E-01 1.0486E-04 1.0486E-04 1.0000E+00 1.0486E-04 1.0486E-04 1.1975E-04 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 4.000E+00 1.000E-01 6.000E+01 9.8235E-01 9.8235E-01 1.0000E+00 9.8235E-01 9.8235E-01 9.8563E-01 25 4.000E+00 2.500E-01 6.000E+01 9.5549E-01 9.5549E-01 1.0000E+00 9.5549E-01 9.5549E-01 9.6346E-01 26 4.000E+00 5.000E-01 6.000E+01 9.0991E-01 9.0991E-01 1.0000E+00 9.0991E-01 9.0991E-01 9.2506E-01 27 4.001E+00 1.000E+00 6.000E+01 8.1708E-01 8.1708E-01 1.0000E+00 8.1708E-01 8.1708E-01 8.4418E-01 28 4.001E+00 1.500E+00 6.000E+01 7.2433E-01 7.2433E-01 1.0000E+00 7.2433E-01 7.2433E-01 7.6023E-01 29 4.001E+00 2.000E+00 6.000E+01 6.3409E-01 6.3409E-01 1.0000E+00 6.3409E-01 6.3409E-01 6.7584E-01 30 4.002E+00 3.000E+00 6.000E+01 4.6851E-01 4.6851E-01 1.0000E+00 4.6851E-01 4.6851E-01 5.1443E-01 31 4.003E+00 4.000E+00 6.000E+01 3.3035E-01 3.3035E-01 1.0000E+00 3.3035E-01 3.3035E-01 3.7320E-01 32 4.003E+00 5.000E+00 6.000E+01 2.2277E-01 2.2277E-01 1.0000E+00 2.2277E-01 2.2277E-01 2.5861E-01 33 4.004E+00 6.000E+00 6.000E+01 1.4397E-01 1.4397E-01 1.0000E+00 1.4397E-01 1.4397E-01 1.7154E-01 34 4.005E+00 7.000E+00 6.000E+01 8.9333E-02 8.9333E-02 1.0000E+00 8.9333E-02 8.9333E-02 1.0914E-01 35 4.006E+00 8.000E+00 6.000E+01 5.3319E-02 5.3319E-02 1.0000E+00 5.3319E-02 5.3319E-02 6.6723E-02 36 4.006E+00 9.000E+00 6.000E+01 3.0663E-02 3.0663E-02 1.0000E+00 3.0663E-02 3.0663E-02 3.9267E-02 37 4.007E+00 1.000E+01 6.000E+01 1.7018E-02 1.7018E-02 1.0000E+00 1.7018E-02 1.7018E-02 2.2282E-02 38 4.009E+00 1.250E+01 6.000E+01 3.3752E-03 3.3752E-03 1.0000E+00 3.3752E-03 3.3752E-03 4.6546E-03 39 4.010E+00 1.500E+01 6.000E+01 5.5271E-04 5.5271E-04 1.0000E+00 5.5271E-04 5.5271E-04 7.9919E-04 40 4.012E+00 1.750E+01 6.000E+01 7.6140E-05 7.6140E-05 1.0000E+00 7.6140E-05 7.6140E-05 1.1498E-04 41 4.014E+00 2.000E+01 6.000E+01 8.9686E-06 8.9686E-06 1.0000E+00 8.9686E-06 8.9686E-06 1.4094E-05 42 4.017E+00 2.500E+01 6.000E+01 8.2229E-08 8.2229E-08 1.0000E+00 8.2229E-08 8.2229E-08 1.3872E-07 43 4.021E+00 3.000E+01 6.000E+01 4.6855E-10 4.6855E-10 1.0000E+00 4.6855E-10 4.6855E-10 8.4019E-10 44 4.024E+00 3.500E+01 6.000E+01 1.7876E-12 1.7876E-12 1.0000E+00 1.7876E-12 1.7876E-12 3.3804E-12 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 2.500E-01 3.482E+00 0.00E+00 3.48226E+00 1.454E-05 1.454E-05 1.480E-05 3 2.500E-01 2.500E-01 8.705E+00 0.00E+00 8.70508E+00 3.537E-05 3.537E-05 3.700E-05 4 5.000E-01 2.500E-01 1.741E+01 0.00E+00 1.74086E+01 6.752E-05 6.752E-05 7.398E-05 5 1.000E+00 2.500E-01 3.481E+01 0.00E+00 3.48118E+01 1.226E-04 1.226E-04 1.479E-04 6 1.500E+00 2.500E-01 5.221E+01 0.00E+00 5.22103E+01 1.661E-04 1.661E-04 2.219E-04 7 2.000E+00 2.500E-01 6.960E+01 0.00E+00 6.96048E+01 1.992E-04 1.992E-04 2.958E-04 8 3.000E+00 2.500E-01 1.044E+02 0.00E+00 1.04383E+02 2.394E-04 2.394E-04 4.435E-04 9 4.000E+00 2.500E-01 1.392E+02 0.00E+00 1.39151E+02 2.528E-04 2.528E-04 5.912E-04 10 5.000E+00 2.500E-01 1.739E+02 0.00E+00 1.73909E+02 2.481E-04 2.481E-04 7.388E-04 11 6.000E+00 2.500E-01 2.087E+02 0.00E+00 2.08660E+02 2.322E-04 2.322E-04 8.864E-04 12 7.000E+00 2.500E-01 2.434E+02 0.00E+00 2.43407E+02 2.101E-04 2.101E-04 1.034E-03 13 8.000E+00 2.500E-01 2.781E+02 0.00E+00 2.78149E+02 1.855E-04 1.855E-04 1.181E-03 14 9.000E+00 2.500E-01 3.129E+02 0.00E+00 3.12887E+02 1.607E-04 1.607E-04 1.329E-03 15 1.000E+01 2.500E-01 3.476E+02 0.00E+00 3.47624E+02 1.371E-04 1.371E-04 1.476E-03 16 1.250E+01 2.500E-01 4.345E+02 0.00E+00 4.34457E+02 8.794E-05 8.794E-05 1.845E-03 17 1.500E+01 2.500E-01 5.213E+02 0.00E+00 5.21283E+02 5.377E-05 5.377E-05 2.213E-03 18 1.750E+01 2.500E-01 6.081E+02 0.00E+00 6.08105E+02 3.185E-05 3.185E-05 2.581E-03 19 2.000E+01 2.500E-01 6.949E+02 0.00E+00 6.94925E+02 1.844E-05 1.844E-05 2.949E-03 20 2.500E+01 2.500E-01 8.686E+02 0.00E+00 8.68564E+02 5.904E-06 5.904E-06 3.685E-03 21 3.000E+01 2.500E-01 1.042E+03 0.00E+00 1.04220E+03 1.812E-06 1.812E-06 4.420E-03 22 3.500E+01 2.500E-01 1.216E+03 0.00E+00 1.21584E+03 5.405E-07 5.405E-07 5.154E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 6.000E+01 3.482E+00 0.00E+00 3.48219E+00 1.454E-05 1.454E-05 1.480E-05 25 2.500E-01 6.000E+01 8.704E+00 0.00E+00 8.70447E+00 3.535E-05 3.535E-05 3.699E-05 26 5.000E-01 6.000E+01 1.741E+01 0.00E+00 1.74056E+01 6.731E-05 6.731E-05 7.397E-05 27 1.000E+00 6.000E+01 3.480E+01 0.00E+00 3.47980E+01 1.208E-04 1.208E-04 1.479E-04 28 1.500E+00 6.000E+01 5.218E+01 0.00E+00 5.21775E+01 1.606E-04 1.606E-04 2.217E-04 29 2.000E+00 6.000E+01 6.954E+01 0.00E+00 6.95444E+01 1.874E-04 1.874E-04 2.955E-04 30 3.000E+00 6.000E+01 1.042E+02 0.00E+00 1.04242E+02 2.075E-04 2.075E-04 4.429E-04 31 4.000E+00 6.000E+01 1.389E+02 0.00E+00 1.38892E+02 1.949E-04 1.949E-04 5.901E-04 32 5.000E+00 6.000E+01 1.735E+02 0.00E+00 1.73498E+02 1.642E-04 1.642E-04 7.371E-04 33 6.000E+00 6.000E+01 2.081E+02 0.00E+00 2.08062E+02 1.272E-04 1.272E-04 8.839E-04 34 7.000E+00 6.000E+01 2.426E+02 0.00E+00 2.42585E+02 9.205E-05 9.205E-05 1.030E-03 35 8.000E+00 6.000E+01 2.771E+02 0.00E+00 2.77069E+02 6.275E-05 6.275E-05 1.177E-03 36 9.000E+00 6.000E+01 3.115E+02 0.00E+00 3.11515E+02 4.057E-05 4.057E-05 1.323E-03 37 1.000E+01 6.000E+01 3.459E+02 0.00E+00 3.45927E+02 2.500E-05 2.500E-05 1.469E-03 38 1.250E+01 6.000E+01 4.318E+02 0.00E+00 4.31809E+02 6.188E-06 6.188E-06 1.834E-03 39 1.500E+01 6.000E+01 5.175E+02 0.00E+00 5.17499E+02 1.214E-06 1.214E-06 2.197E-03 40 1.750E+01 6.000E+01 6.030E+02 0.00E+00 6.03017E+02 1.949E-07 1.949E-07 2.560E-03 41 2.000E+01 6.000E+01 6.884E+02 0.00E+00 6.88378E+02 2.620E-08 2.620E-08 2.921E-03 42 2.500E+01 6.000E+01 8.587E+02 0.00E+00 8.58686E+02 2.995E-10 2.995E-10 3.643E-03 43 3.000E+01 6.000E+01 1.029E+03 0.00E+00 1.02852E+03 2.044E-12 2.044E-12 4.362E-03 44 3.500E+01 6.000E+01 1.198E+03 0.00E+00 1.19795E+03 9.078E-15 9.078E-15 5.078E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 2.500E-01 3.482E+00 1.454E-05 1.480E-05 6.8994E-05 6.9171E-05 6.7954E-05 3 2.500E-01 2.500E-01 8.705E+00 3.537E-05 3.700E-05 6.8993E-05 6.9434E-05 6.6384E-05 4 5.000E-01 2.500E-01 1.741E+01 6.752E-05 7.398E-05 6.8990E-05 6.9873E-05 6.3769E-05 5 1.000E+00 2.500E-01 3.481E+01 1.226E-04 1.479E-04 6.8985E-05 7.0750E-05 5.8610E-05 6 1.500E+00 2.500E-01 5.221E+01 1.661E-04 2.219E-04 6.8980E-05 7.1626E-05 5.3612E-05 7 2.000E+00 2.500E-01 6.960E+01 1.992E-04 2.958E-04 6.8975E-05 7.2503E-05 4.8833E-05 8 3.000E+00 2.500E-01 1.044E+02 2.394E-04 4.435E-04 6.8965E-05 7.4255E-05 4.0077E-05 9 4.000E+00 2.500E-01 1.392E+02 2.528E-04 5.912E-04 6.8954E-05 7.6007E-05 3.2504E-05 10 5.000E+00 2.500E-01 1.739E+02 2.481E-04 7.388E-04 6.8944E-05 7.7757E-05 2.6116E-05 11 6.000E+00 2.500E-01 2.087E+02 2.322E-04 8.864E-04 6.8934E-05 7.9507E-05 2.0829E-05 12 7.000E+00 2.500E-01 2.434E+02 2.101E-04 1.034E-03 6.8924E-05 8.1257E-05 1.6515E-05 13 8.000E+00 2.500E-01 2.781E+02 1.855E-04 1.181E-03 6.8914E-05 8.3006E-05 1.3035E-05 14 9.000E+00 2.500E-01 3.129E+02 1.607E-04 1.329E-03 6.8904E-05 8.4755E-05 1.0249E-05 15 1.000E+01 2.500E-01 3.476E+02 1.371E-04 1.476E-03 6.8893E-05 8.6503E-05 8.0354E-06 16 1.250E+01 2.500E-01 4.345E+02 8.794E-05 1.845E-03 6.8868E-05 9.0872E-05 4.3317E-06 17 1.500E+01 2.500E-01 5.213E+02 5.377E-05 2.213E-03 6.8843E-05 9.5240E-05 2.3139E-06 18 1.750E+01 2.500E-01 6.081E+02 3.185E-05 2.581E-03 6.8817E-05 9.9605E-05 1.2290E-06 19 2.000E+01 2.500E-01 6.949E+02 1.844E-05 2.949E-03 6.8792E-05 1.0397E-04 6.5019E-07 20 2.500E+01 2.500E-01 8.686E+02 5.904E-06 3.685E-03 6.8741E-05 1.1269E-04 1.8056E-07 21 3.000E+01 2.500E-01 1.042E+03 1.812E-06 4.420E-03 6.8690E-05 1.2141E-04 4.9775E-08 22 3.500E+01 2.500E-01 1.216E+03 5.405E-07 5.154E-03 6.8640E-05 1.3012E-04 1.3645E-08 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 6.000E+01 3.482E+00 1.454E-05 1.480E-05 6.8994E-05 6.9171E-05 6.7950E-05 25 2.500E-01 6.000E+01 8.704E+00 3.535E-05 3.699E-05 6.8993E-05 6.9434E-05 6.6343E-05 26 5.000E-01 6.000E+01 1.741E+01 6.731E-05 7.397E-05 6.8990E-05 6.9872E-05 6.3578E-05 27 1.000E+00 6.000E+01 3.480E+01 1.208E-04 1.479E-04 6.8985E-05 7.0749E-05 5.7808E-05 28 1.500E+00 6.000E+01 5.218E+01 1.606E-04 2.217E-04 6.8980E-05 7.1625E-05 5.1880E-05 29 2.000E+00 6.000E+01 6.954E+01 1.874E-04 2.955E-04 6.8975E-05 7.2500E-05 4.5971E-05 30 3.000E+00 6.000E+01 1.042E+02 2.075E-04 4.429E-04 6.8965E-05 7.4248E-05 3.4786E-05 31 4.000E+00 6.000E+01 1.389E+02 1.949E-04 5.901E-04 6.8955E-05 7.5994E-05 2.5105E-05 32 5.000E+00 6.000E+01 1.735E+02 1.642E-04 7.371E-04 6.8944E-05 7.7737E-05 1.7318E-05 33 6.000E+00 6.000E+01 2.081E+02 1.272E-04 8.839E-04 6.8934E-05 7.9477E-05 1.1442E-05 34 7.000E+00 6.000E+01 2.426E+02 9.205E-05 1.030E-03 6.8924E-05 8.1216E-05 7.2552E-06 35 8.000E+00 6.000E+01 2.771E+02 6.275E-05 1.177E-03 6.8914E-05 8.2952E-05 4.4229E-06 36 9.000E+00 6.000E+01 3.115E+02 4.057E-05 1.323E-03 6.8904E-05 8.4686E-05 2.5967E-06 37 1.000E+01 6.000E+01 3.459E+02 2.500E-05 1.469E-03 6.8894E-05 8.6418E-05 1.4706E-06 38 1.250E+01 6.000E+01 4.318E+02 6.188E-06 1.834E-03 6.8869E-05 9.0739E-05 3.0626E-07 39 1.500E+01 6.000E+01 5.175E+02 1.214E-06 2.197E-03 6.8844E-05 9.5050E-05 5.2535E-08 40 1.750E+01 6.000E+01 6.030E+02 1.949E-07 2.560E-03 6.8819E-05 9.9350E-05 7.5645E-09 41 2.000E+01 6.000E+01 6.884E+02 2.620E-08 2.921E-03 6.8794E-05 1.0364E-04 9.2950E-10 42 2.500E+01 6.000E+01 8.587E+02 2.995E-10 3.643E-03 6.8744E-05 1.1220E-04 9.2258E-12 43 3.000E+01 6.000E+01 1.029E+03 2.044E-12 4.362E-03 6.8694E-05 1.2072E-04 5.6564E-14 44 3.500E+01 6.000E+01 1.198E+03 9.078E-15 5.078E-03 6.8645E-05 1.2922E-04 2.3099E-16 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.1421 (1/Gy), alpha/beta = 5.0985 (Gy), lamda1 = 2.773E+00 (1/h), lamda2 = 5.217E-02 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 4.000E-01 9.640E+01 1.000E-01 2.500E-01 7.137E-01 9.931E-01 1.266E+01 9.8565E-01 9.824158E-01 3 1.000E+00 9.700E+01 2.500E-01 2.500E-01 4.774E-01 9.828E-01 5.394E+00 9.6380E-01 9.560703E-01 4 2.000E+00 9.800E+01 5.000E-01 2.500E-01 2.959E-01 9.661E-01 2.921E+00 9.2699E-01 9.126469E-01 5 4.000E+00 1.000E+02 1.000E+00 2.500E-01 1.641E-01 9.339E-01 1.655E+00 8.5296E-01 8.284200E-01 6 6.000E+00 1.020E+02 1.500E+00 2.500E-01 1.130E-01 9.033E-01 1.220E+00 7.7973E-01 7.484974E-01 7 8.000E+00 1.040E+02 2.000E+00 2.500E-01 8.610E-02 8.743E-01 9.956E-01 7.0861E-01 6.735293E-01 8 1.200E+01 1.080E+02 3.000E+00 2.500E-01 5.831E-02 8.203E-01 7.589E-01 5.7633E-01 5.397242E-01 9 1.600E+01 1.120E+02 4.000E+00 2.500E-01 4.407E-02 7.713E-01 6.301E-01 4.6073E-01 4.276416E-01 10 2.000E+01 1.160E+02 5.000E+00 2.500E-01 3.542E-02 7.269E-01 5.460E-01 3.6320E-01 3.358621E-01 11 2.400E+01 1.200E+02 6.000E+00 2.500E-01 2.960E-02 6.863E-01 4.852E-01 2.8309E-01 2.619738E-01 12 2.800E+01 1.240E+02 7.000E+00 2.500E-01 2.543E-02 6.494E-01 4.382E-01 2.1862E-01 2.032491E-01 13 3.200E+01 1.280E+02 8.000E+00 2.500E-01 2.229E-02 6.156E-01 4.005E-01 1.6757E-01 1.570312E-01 14 3.600E+01 1.320E+02 9.000E+00 2.500E-01 1.984E-02 5.846E-01 3.692E-01 1.2767E-01 1.209290E-01 15 4.000E+01 1.360E+02 1.000E+01 2.500E-01 1.787E-02 5.561E-01 3.427E-01 9.6791E-02 9.289097E-02 16 5.000E+01 1.460E+02 1.250E+01 2.500E-01 1.432E-02 4.944E-01 2.909E-01 4.7675E-02 4.766836E-02 17 6.000E+01 1.560E+02 1.500E+01 2.500E-01 1.195E-02 4.437E-01 2.529E-01 2.3130E-02 2.429598E-02 18 7.000E+01 1.660E+02 1.750E+01 2.500E-01 1.025E-02 4.016E-01 2.235E-01 1.1122E-02 1.233835E-02 19 8.000E+01 1.760E+02 2.000E+01 2.500E-01 8.976E-03 3.662E-01 2.002E-01 5.3192E-03 6.253634E-03 20 1.000E+02 1.960E+02 2.500E+01 2.500E-01 7.187E-03 3.103E-01 1.655E-01 1.2068E-03 1.602259E-03 21 1.200E+02 2.160E+02 3.000E+01 2.500E-01 5.993E-03 2.685E-01 1.410E-01 2.7250E-04 4.099776E-04 22 1.400E+02 2.360E+02 3.500E+01 2.500E-01 5.139E-03 2.364E-01 1.227E-01 6.1428E-05 1.048632E-04 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 1.667E-03 9.600E+01 1.000E-01 6.000E+01 9.985E-01 1.000E+00 1.291E+01 9.8561E-01 9.823482E-01 25 4.167E-03 9.600E+01 2.500E-01 6.000E+01 9.962E-01 9.999E-01 5.743E+00 9.6342E-01 9.554881E-01 26 8.333E-03 9.601E+01 5.000E-01 6.000E+01 9.923E-01 9.999E-01 3.351E+00 9.2496E-01 9.099116E-01 27 1.667E-02 9.602E+01 1.000E+00 6.000E+01 9.848E-01 9.997E-01 2.149E+00 8.4383E-01 8.170796E-01 28 2.500E-02 9.603E+01 1.500E+00 6.000E+01 9.773E-01 9.996E-01 1.744E+00 7.5937E-01 7.243283E-01 29 3.333E-02 9.603E+01 2.000E+00 6.000E+01 9.699E-01 9.994E-01 1.537E+00 6.7418E-01 6.340859E-01 30 5.000E-02 9.605E+01 3.000E+00 6.000E+01 9.553E-01 9.991E-01 1.323E+00 5.1052E-01 4.685101E-01 31 6.667E-02 9.607E+01 4.000E+00 6.000E+01 9.411E-01 9.988E-01 1.209E+00 3.6678E-01 3.303530E-01 32 8.333E-02 9.608E+01 5.000E+00 6.000E+01 9.272E-01 9.986E-01 1.135E+00 2.5025E-01 2.227749E-01 33 1.000E-01 9.610E+01 6.000E+00 6.000E+01 9.136E-01 9.983E-01 1.082E+00 1.6229E-01 1.439681E-01 34 1.167E-01 9.612E+01 7.000E+00 6.000E+01 9.004E-01 9.980E-01 1.040E+00 1.0013E-01 8.933255E-02 35 1.333E-01 9.613E+01 8.000E+00 6.000E+01 8.874E-01 9.977E-01 1.006E+00 5.8823E-02 5.331865E-02 36 1.500E-01 9.615E+01 9.000E+00 6.000E+01 8.747E-01 9.974E-01 9.770E-01 3.2930E-02 3.066281E-02 37 1.667E-01 9.617E+01 1.000E+01 6.000E+01 8.622E-01 9.971E-01 9.516E-01 1.7580E-02 1.701782E-02 38 2.083E-01 9.621E+01 1.250E+01 6.000E+01 8.323E-01 9.964E-01 8.989E-01 2.9886E-03 3.375190E-03 39 2.500E-01 9.625E+01 1.500E+01 6.000E+01 8.040E-01 9.957E-01 8.561E-01 3.8340E-04 5.527133E-04 40 2.917E-01 9.629E+01 1.750E+01 6.000E+01 7.772E-01 9.949E-01 8.196E-01 3.7470E-05 7.614017E-05 41 3.333E-01 9.633E+01 2.000E+01 6.000E+01 7.517E-01 9.942E-01 7.875E-01 2.8136E-06 8.968565E-06 42 4.167E-01 9.642E+01 2.500E+01 6.000E+01 7.047E-01 9.928E-01 7.325E-01 7.4118E-09 8.222930E-08 43 5.000E-01 9.650E+01 3.000E+01 6.000E+01 6.622E-01 9.914E-01 6.864E-01 7.3830E-12 4.685488E-10 44 5.833E-01 9.658E+01 3.500E+01 6.000E+01 6.237E-01 9.899E-01 6.466E-01 2.9001E-15 1.787597E-12 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 4.017E+00 1.000E-01 9.8242E-01 9.8242E-01 9.8566E-01 3.7441E-01 3.7441E-01 3.7319E-01 3.7319E-01 3 4.042E+00 2.500E-01 9.5607E-01 9.5607E-01 9.6384E-01 3.8440E-01 3.8440E-01 3.8143E-01 3.8143E-01 4 4.083E+00 5.000E-01 9.1265E-01 9.1265E-01 9.2708E-01 4.0146E-01 4.0146E-01 3.9571E-01 3.9571E-01 5 4.167E+00 1.000E+00 8.2842E-01 8.2842E-01 8.5324E-01 4.3674E-01 4.3674E-01 4.2603E-01 4.2603E-01 6 4.250E+00 1.500E+00 7.4850E-01 7.4850E-01 7.8037E-01 4.7308E-01 4.7308E-01 4.5824E-01 4.5824E-01 7 4.333E+00 2.000E+00 6.7353E-01 6.7353E-01 7.0979E-01 5.0991E-01 5.0991E-01 4.9175E-01 4.9175E-01 8 4.500E+00 3.000E+00 5.3972E-01 5.3972E-01 5.7901E-01 5.8291E-01 5.8291E-01 5.6046E-01 5.6046E-01 9 4.667E+00 4.000E+00 4.2764E-01 4.2764E-01 4.6517E-01 6.5205E-01 6.5205E-01 6.2803E-01 6.2803E-01 10 4.833E+00 5.000E+00 3.3586E-01 3.3586E-01 3.6929E-01 7.1472E-01 7.1472E-01 6.9122E-01 6.9122E-01 11 5.000E+00 6.000E+00 2.6197E-01 2.6197E-01 2.9047E-01 7.6953E-01 7.6953E-01 7.4791E-01 7.4791E-01 12 5.167E+00 7.000E+00 2.0325E-01 2.0325E-01 2.2684E-01 8.1607E-01 8.1607E-01 7.9705E-01 7.9705E-01 13 5.333E+00 8.000E+00 1.5703E-01 1.5703E-01 1.7615E-01 8.5468E-01 8.5468E-01 8.3849E-01 8.3849E-01 14 5.500E+00 9.000E+00 1.2093E-01 1.2093E-01 1.3619E-01 8.8610E-01 8.8610E-01 8.7268E-01 8.7268E-01 15 5.667E+00 1.000E+01 9.2891E-02 9.2891E-02 1.0493E-01 9.1129E-01 9.1129E-01 9.0038E-01 9.0038E-01 16 6.083E+00 1.250E+01 4.7668E-02 4.7668E-02 5.4121E-02 9.5345E-01 9.5345E-01 9.4732E-01 9.4732E-01 17 6.500E+00 1.500E+01 2.4296E-02 2.4296E-02 2.7659E-02 9.7600E-01 9.7600E-01 9.7272E-01 9.7272E-01 18 6.917E+00 1.750E+01 1.2338E-02 1.2338E-02 1.4067E-02 9.8774E-01 9.8774E-01 9.8603E-01 9.8603E-01 19 7.333E+00 2.000E+01 6.2536E-03 6.2536E-03 7.1351E-03 9.9377E-01 9.9377E-01 9.9289E-01 9.9289E-01 20 8.167E+00 2.500E+01 1.6023E-03 1.6023E-03 1.8293E-03 9.9840E-01 9.9840E-01 9.9817E-01 9.9817E-01 21 9.000E+00 3.000E+01 4.0998E-04 4.0998E-04 4.6815E-04 9.9959E-01 9.9959E-01 9.9953E-01 9.9953E-01 22 9.833E+00 3.500E+01 1.0486E-04 1.0486E-04 1.1975E-04 9.9990E-01 9.9990E-01 9.9988E-01 9.9988E-01 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 4.000E+00 1.000E-01 9.8235E-01 9.8235E-01 9.8563E-01 3.7443E-01 3.7443E-01 3.7320E-01 3.7320E-01 25 4.000E+00 2.500E-01 9.5549E-01 9.5549E-01 9.6346E-01 3.8462E-01 3.8462E-01 3.8157E-01 3.8157E-01 26 4.000E+00 5.000E-01 9.0991E-01 9.0991E-01 9.2506E-01 4.0256E-01 4.0256E-01 3.9651E-01 3.9651E-01 27 4.001E+00 1.000E+00 8.1708E-01 8.1708E-01 8.4418E-01 4.4172E-01 4.4172E-01 4.2991E-01 4.2991E-01 28 4.001E+00 1.500E+00 7.2433E-01 7.2433E-01 7.6023E-01 4.8465E-01 4.8465E-01 4.6756E-01 4.6756E-01 29 4.001E+00 2.000E+00 6.3409E-01 6.3409E-01 6.7584E-01 5.3042E-01 5.3042E-01 5.0873E-01 5.0873E-01 30 4.002E+00 3.000E+00 4.6851E-01 4.6851E-01 5.1443E-01 6.2593E-01 6.2593E-01 5.9784E-01 5.9784E-01 31 4.003E+00 4.000E+00 3.3035E-01 3.3035E-01 3.7320E-01 7.1867E-01 7.1867E-01 6.8853E-01 6.8853E-01 32 4.003E+00 5.000E+00 2.2277E-01 2.2277E-01 2.5861E-01 8.0029E-01 8.0029E-01 7.7212E-01 7.7212E-01 33 4.004E+00 6.000E+00 1.4397E-01 1.4397E-01 1.7154E-01 8.6592E-01 8.6592E-01 8.4236E-01 8.4236E-01 34 4.005E+00 7.000E+00 8.9333E-02 8.9333E-02 1.0914E-01 9.1454E-01 9.1454E-01 8.9661E-01 8.9661E-01 35 4.006E+00 8.000E+00 5.3319E-02 5.3319E-02 6.6723E-02 9.4808E-01 9.4808E-01 9.3545E-01 9.3545E-01 36 4.006E+00 9.000E+00 3.0663E-02 3.0663E-02 3.9267E-02 9.6980E-01 9.6980E-01 9.6149E-01 9.6149E-01 37 4.007E+00 1.000E+01 1.7018E-02 1.7018E-02 2.2282E-02 9.8313E-01 9.8313E-01 9.7796E-01 9.7796E-01 38 4.009E+00 1.250E+01 3.3752E-03 3.3752E-03 4.6546E-03 9.9663E-01 9.9663E-01 9.9536E-01 9.9536E-01 39 4.010E+00 1.500E+01 5.5271E-04 5.5271E-04 7.9919E-04 9.9945E-01 9.9945E-01 9.9920E-01 9.9920E-01 40 4.012E+00 1.750E+01 7.6140E-05 7.6140E-05 1.1498E-04 9.9992E-01 9.9992E-01 9.9989E-01 9.9989E-01 41 4.014E+00 2.000E+01 8.9686E-06 8.9686E-06 1.4094E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 42 4.017E+00 2.500E+01 8.2229E-08 8.2229E-08 1.3872E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.021E+00 3.000E+01 4.6855E-10 4.6855E-10 8.4019E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.024E+00 3.500E+01 1.7876E-12 1.7876E-12 3.3804E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 4.000E-01 1.667E-02 0.0000E+00 1.0000E-01 0.0000E+00 2.5000E-01 3 1.000E+00 4.167E-02 0.0000E+00 2.5000E-01 0.0000E+00 2.5000E-01 4 2.000E+00 8.333E-02 0.0000E+00 5.0000E-01 0.0000E+00 2.5000E-01 5 4.000E+00 1.667E-01 0.0000E+00 1.0000E+00 0.0000E+00 2.5000E-01 6 6.000E+00 2.500E-01 0.0000E+00 1.5000E+00 0.0000E+00 2.5000E-01 7 8.000E+00 3.333E-01 0.0000E+00 2.0000E+00 0.0000E+00 2.5000E-01 8 1.200E+01 5.000E-01 0.0000E+00 3.0000E+00 0.0000E+00 2.5000E-01 9 1.600E+01 6.667E-01 0.0000E+00 4.0000E+00 0.0000E+00 2.5000E-01 10 2.000E+01 8.333E-01 0.0000E+00 5.0000E+00 0.0000E+00 2.5000E-01 11 2.400E+01 1.000E+00 0.0000E+00 6.0000E+00 0.0000E+00 2.5000E-01 12 2.800E+01 1.167E+00 0.0000E+00 7.0000E+00 0.0000E+00 2.5000E-01 13 3.200E+01 1.333E+00 0.0000E+00 8.0000E+00 0.0000E+00 2.5000E-01 14 3.600E+01 1.500E+00 0.0000E+00 9.0000E+00 0.0000E+00 2.5000E-01 15 4.000E+01 1.667E+00 0.0000E+00 1.0000E+01 0.0000E+00 2.5000E-01 16 5.000E+01 2.083E+00 0.0000E+00 1.2500E+01 0.0000E+00 2.5000E-01 17 6.000E+01 2.500E+00 0.0000E+00 1.5000E+01 0.0000E+00 2.5000E-01 18 7.000E+01 2.917E+00 0.0000E+00 1.7500E+01 0.0000E+00 2.5000E-01 19 8.000E+01 3.333E+00 0.0000E+00 2.0000E+01 0.0000E+00 2.5000E-01 20 1.000E+02 4.167E+00 0.0000E+00 2.5000E+01 0.0000E+00 2.5000E-01 21 1.200E+02 5.000E+00 0.0000E+00 3.0000E+01 0.0000E+00 2.5000E-01 22 1.400E+02 5.833E+00 0.0000E+00 3.5000E+01 0.0000E+00 2.5000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 1.667E-03 6.944E-05 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E+01 25 4.167E-03 1.736E-04 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E+01 26 8.333E-03 3.472E-04 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E+01 27 1.667E-02 6.944E-04 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E+01 28 2.500E-02 1.042E-03 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E+01 29 3.333E-02 1.389E-03 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E+01 30 5.000E-02 2.083E-03 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E+01 31 6.667E-02 2.778E-03 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E+01 32 8.333E-02 3.472E-03 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E+01 33 1.000E-01 4.167E-03 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E+01 34 1.167E-01 4.861E-03 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E+01 35 1.333E-01 5.556E-03 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E+01 36 1.500E-01 6.250E-03 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E+01 37 1.667E-01 6.944E-03 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E+01 38 2.083E-01 8.681E-03 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E+01 39 2.500E-01 1.042E-02 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E+01 40 2.917E-01 1.215E-02 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E+01 41 3.333E-01 1.389E-02 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E+01 42 4.167E-01 1.736E-02 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E+01 43 5.000E-01 2.083E-02 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E+01 44 5.833E-01 2.431E-02 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 1.01500E-02 VC 2.00J 25-SEP-2003 20-NOV-2003 06:41:17 PM