VC 2.00I 15-JUL-2003 02-AUG-2003 10:54:01 AM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\du145.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\du145.radx (7 exposures) XDAT: ..\xdat\du145.xdat (7 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 1.4853645E-03 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 3.0357103E-02 2202 CLRP RHT 1.00000E-02 1.20000E+01 8.00000E+00 1.5248097E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 1.77155E-02 (nfom=360, nsim=2520, nmx=7, nox=7, ndf=3, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-2.279E-01 max=1.631E-01, mean=1.8677E-02, stdev=1.3242E-01, var=1.7534E-02 Student's T test (mean=0, NDF=3): Pr>ABS(0.37317)= 7.3383E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.91685)=4.625E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-8.615E-02 max=6.164E-02, mean=7.0592E-03, stdev=5.0049E-02, var=2.5049E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.37317)= 7.3383E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.91685)=4.625E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 5.74228E-12 3.52920E-03 20.000000 Complex DSB = 1.43557E-12 8.82301E-04 5.000000 Total DSB = 7.17785E-12 4.41151E-03 25.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 3.035710E-02 (=3.036%) PHI2= 3.035710E-02 (=3.036%) (1-A1)*PHI1= 7.589276E-03 (=0.759%) (1-A2)*PHI2= 2.276783E-02 (=2.277%) (1-A1)*(1-PHI1)= 2.424107E-01 (=24.241%) (1-A2)*(1-PHI2)= 7.272322E-01 (=72.723%) RHT1= 0.250000 h (=15.00 minute) RHT2= 1.524810 h (=91.49 minute) LAM1= 2.7725887E+00 (1/h) LAM2= 4.5457947E-01 (1/h) BMR= 1.4853645E-03 (1/h) LAM1/BMR= 1.8666049E+03 LAM2/BMR= 3.0603900E+02 (LAM1+LAM2)/BMR= 2.1726439E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.5179E-01 + 1.1384E-01 = 2.6562465E-01 (1/Gy) beta: 3.6782E-02 + 2.0089E-02 = 5.6870807E-02 (1/Gy^2) alpha/beta: 4.6706679 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (DU 145 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 5.4651E-06 4.5907E-04 8.4000E+01 1.00290E+00 1.43E-01 9.99878E-01 -3.0223E-03 2 1.1971E-02 1.0056E+00 8.4000E+01 6.91070E-01 1.43E-01 7.23696E-01 4.5083E-02 3 2.3873E-02 2.0053E+00 8.4000E+01 4.93390E-01 1.43E-01 4.71554E-01 -4.6305E-02 4 3.5624E-02 2.9924E+00 8.4000E+01 2.66000E-01 1.43E-01 2.80068E-01 5.0232E-02 5 4.7689E-02 4.0059E+00 8.4000E+01 1.24820E-01 1.43E-01 1.49144E-01 1.6309E-01 6 5.9469E-02 4.9954E+00 8.4000E+01 9.07040E-02 1.43E-01 7.38667E-02 -2.2794E-01 7 7.1396E-02 5.9973E+00 8.4000E+01 2.83880E-02 1.43E-01 3.33820E-02 1.4960E-01 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-2.279E-01 max=1.631E-01, mean=1.8677E-02, stdev=1.3242E-01, var=1.7534E-02 Student's T test (mean=0, NDF=3): Pr>ABS(0.37317)= 7.3383E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.91685)=4.625E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-8.615E-02 max=6.164E-02, mean=7.0592E-03, stdev=5.0049E-02, var=2.5049E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.37317)= 7.3383E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.91685)=4.625E-01 (passed normality test) NOX=7, NPAR=3 CFE.SF: Cell survival data for DU 145 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 5.4651E-06 4.5907E-04 8.4000E+01 -2.90000E-03 1.00290E+00 1.00E+01 2 2 1.1971E-02 1.0056E+00 8.4000E+01 3.08930E-01 6.91070E-01 1.00E+01 3 3 2.3873E-02 2.0053E+00 8.4000E+01 5.06610E-01 4.93390E-01 1.00E+01 4 4 3.5624E-02 2.9924E+00 8.4000E+01 7.34000E-01 2.66000E-01 1.00E+01 5 5 4.7689E-02 4.0059E+00 8.4000E+01 8.75180E-01 1.24820E-01 1.00E+01 6 6 5.9469E-02 4.9954E+00 8.4000E+01 9.09296E-01 9.07040E-02 1.00E+01 7 7 7.1396E-02 5.9973E+00 8.4000E+01 9.71612E-01 2.83880E-02 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (DU 145). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 5.465E-06 1.200E+01 4.000E+02 4.5907E-04 -6.3080E+00 -2.8958E-03 2 2 1.197E-02 1.200E+01 4.000E+02 1.0056E+00 3.6746E-01 3.6951E-01 3 3 2.387E-02 1.200E+01 4.000E+02 2.0053E+00 3.5229E-01 7.0646E-01 4 4 3.562E-02 1.200E+01 4.000E+02 2.9924E+00 4.4254E-01 1.3243E+00 5 5 4.769E-02 1.200E+01 4.000E+02 4.0059E+00 5.1945E-01 2.0809E+00 6 6 5.947E-02 1.200E+01 4.000E+02 4.9954E+00 4.8047E-01 2.4002E+00 7 7 7.140E-02 1.200E+01 4.000E+02 5.9973E+00 5.9390E-01 3.5618E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.23307 VC 2.00I 15-JUL-2003 02-AUG-2003 10:54:15 AM