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Calibrated Input File (TLK)
DU-145 Prostate Carcinoma Cells

/*
 REFERENCE:
  Algan O, Stobbe CC, Helt AM, Hanks GE, and Chapman JD. Radiation Inactiviation of Human
  Prostate Cancer Cells: The Role of Apoptosis Radiation Research. 146, 267-275 (1996)

 PREPARED BY: JULIEN PARTOUCHE (julien@tamu.edu)
 DATE: 21-JUL-2003
 REVISED: 02-AUG-2003 RD STEWART
 three-parameter fit instead of four-parameter fit
*/


MODEL: DRM=TLK CKM=QECK
CELL: DNA=5.667D+09 NC=46
IRAD: CL=DSB
CLRP: RHT=HT4R BMR=1.4853645E-03 PHI=PML A0=PMR
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data

! TLK model inputs (simple and complex double strand breaks)
DSB = 20 5 / !Radiation damage to DNA
HT4R = 0.25 1.5248097E+00 / !Half-times for DSB repair
PML = 3.0357103E-02 / !Probability a misrejoined DSB is lethal
PMR = 0.75 0.25 / !Probability DSB is rejoined correctly

! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10

! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09


!IRRADIATION CONDITIONS (single fraction)
RADX: ADR=RX1 AD=RX2
RX1 = 84 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 /

 


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