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Calibrated Input File (RMR)
DU-145 Prostate Carcinoma Cells

/*
 REFERENCE:
  Algan O, Stobbe CC, Helt AM, Hanks GE, and Chapman JD. Radiation Inactiviation of Human
  Prostate Cancer Cells: The Role of Apoptosis Radiation Research. 146, 267-275 (1996)
 

 PREPARED BY: JULIEN PARTOUCHE (julien@tamu.edu)
 DATE: 21-JUL-2003
*/

MODEL: DRM=RMR CKM=QECK !Model Specification
CELL: DNA=5.667D+09 NC=46
IRAD: CL=55 !Radiation damage to DNA
CLRP: RHT=7.4545310E+00 BMR= 1.2652244E-05 PHI= 4.8832831E-03 A0=0.00
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data

! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10

! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0E+00 RCUT=1.0D-09

!IRRADIATION CONDITIONS (single fraction)
RADX: ADR=RX1 AD=RX2
RX1 = 84 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 /

 


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