VC 2.00I 15-JUL-2003 02-AUG-2003 08:03:27 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\hx142\rmr\hx142.inp FNI: U:\archive\hx142\rmr\hx142.inp FNO: U:\archive\hx142\rmr\hx142.out RADX: U:\archive\hx142\rmr\hx142.radx (132 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- RMRM TABLE: Summary of RMR parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 7.17785E-12 4.41151E-03 25.000000 DAMAGE REPAIR/MISREPAIR: A0= 0.000000E+00 (=0.000%) (1-A0)*PHI= 2.136874E-02 (=2.137%) (1-A0)*(1-PHI)= 9.786313E-01 (=97.863%) RHT= 1.937661 h (=116.26 minute) LAM= 3.5772360E-01 (1/h) BMR= 9.1247273E-04 (1/h) LAM/BMR= 3.9203758E+02 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 0.534218 (1/Gy) beta = 0.182246 (1/Gy^2) alpha/beta = 2.931304 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 6.667E-01 7.267E+01 1.000E-01 1.500E-01 5.510E-02 1.067E-10 5.5101E-02 9.463897E-01 3 1.667E+00 7.367E+01 2.500E-01 1.500E-01 1.429E-01 2.178E-10 1.4289E-01 8.668473E-01 4 3.333E+00 7.533E+01 5.000E-01 1.500E-01 2.983E-01 2.968E-10 2.9835E-01 7.420428E-01 5 6.667E+00 7.867E+01 1.000E+00 1.500E-01 6.263E-01 2.992E-10 6.2626E-01 5.345900E-01 6 1.000E+01 7.000E+01 1.500E+00 1.500E-01 9.626E-01 5.185E-09 9.6259E-01 3.819029E-01 7 1.333E+01 7.333E+01 2.000E+00 1.500E-01 1.301E+00 5.268E-09 1.3013E+00 2.721707E-01 8 2.000E+01 8.000E+01 3.000E+00 1.500E-01 1.980E+00 5.298E-09 1.9804E+00 1.380187E-01 9 2.667E+01 8.667E+01 4.000E+00 1.500E-01 2.660E+00 5.300E-09 2.6597E+00 6.996722E-02 10 3.333E+01 9.333E+01 5.000E+00 1.500E-01 3.339E+00 5.300E-09 3.3391E+00 3.546824E-02 11 4.000E+01 1.000E+02 6.000E+00 1.500E-01 4.019E+00 5.300E-09 4.0185E+00 1.797976E-02 12 4.667E+01 1.067E+02 7.000E+00 1.500E-01 4.698E+00 5.300E-09 4.6979E+00 9.114398E-03 13 5.333E+01 1.133E+02 8.000E+00 1.500E-01 5.377E+00 5.300E-09 5.3773E+00 4.620320E-03 14 6.000E+01 1.200E+02 9.000E+00 1.500E-01 6.057E+00 5.300E-09 6.0567E+00 2.342158E-03 15 6.667E+01 1.267E+02 1.000E+01 1.500E-01 6.736E+00 5.300E-09 6.7361E+00 1.187299E-03 16 8.333E+01 1.433E+02 1.250E+01 1.500E-01 8.435E+00 5.300E-09 8.4346E+00 2.172303E-04 17 1.000E+02 1.600E+02 1.500E+01 1.500E-01 1.013E+01 5.300E-09 1.0133E+01 3.974484E-05 18 1.167E+02 1.767E+02 1.750E+01 1.500E-01 1.183E+01 5.300E-09 1.1832E+01 7.271784E-06 19 1.333E+02 1.933E+02 2.000E+01 1.500E-01 1.353E+01 5.300E-09 1.3530E+01 1.330458E-06 20 1.667E+02 2.267E+02 2.500E+01 1.500E-01 1.693E+01 5.300E-09 1.6927E+01 4.453707E-08 21 2.000E+02 2.600E+02 3.000E+01 1.500E-01 2.032E+01 5.300E-09 2.0324E+01 1.490878E-09 22 2.333E+02 2.933E+02 3.500E+01 1.500E-01 2.372E+01 5.300E-09 2.3721E+01 4.990713E-11 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 3.333E-01 7.233E+01 1.000E-01 3.000E-01 5.517E-02 1.074E-10 5.5167E-02 9.463274E-01 25 8.333E-01 7.283E+01 2.500E-01 3.000E-01 1.438E-01 2.473E-10 1.4379E-01 8.660702E-01 26 1.667E+00 7.367E+01 5.000E-01 3.000E-01 3.041E-01 2.991E-10 3.0411E-01 7.377800E-01 27 3.333E+00 7.533E+01 1.000E+00 3.000E-01 6.571E-01 6.583E-11 6.5709E-01 5.183580E-01 28 5.000E+00 7.700E+01 1.500E+00 3.000E-01 1.035E+00 1.042E-10 1.0354E+00 3.550939E-01 29 6.667E+00 7.867E+01 2.000E+00 3.000E-01 1.427E+00 1.248E-10 1.4268E+00 2.400838E-01 30 1.000E+01 7.000E+01 3.000E+00 3.000E-01 2.227E+00 9.543E-09 2.2267E+00 1.078874E-01 31 1.333E+01 7.333E+01 4.000E+00 3.000E-01 3.035E+00 9.682E-09 3.0347E+00 4.808962E-02 32 1.667E+01 7.667E+01 5.000E+00 3.000E-01 3.845E+00 9.719E-09 3.8449E+00 2.138869E-02 33 2.000E+01 8.000E+01 6.000E+00 3.000E-01 4.656E+00 9.729E-09 4.6557E+00 9.507408E-03 34 2.333E+01 8.333E+01 7.000E+00 3.000E-01 5.467E+00 9.732E-09 5.4666E+00 4.225437E-03 35 2.667E+01 8.667E+01 8.000E+00 3.000E-01 6.278E+00 9.733E-09 6.2776E+00 1.877858E-03 36 3.000E+01 9.000E+01 9.000E+00 3.000E-01 7.089E+00 9.733E-09 7.0886E+00 8.345435E-04 37 3.333E+01 9.333E+01 1.000E+01 3.000E-01 7.900E+00 9.733E-09 7.8996E+00 3.708803E-04 38 4.167E+01 1.017E+02 1.250E+01 3.000E-01 9.927E+00 9.733E-09 9.9271E+00 4.883091E-05 39 5.000E+01 1.100E+02 1.500E+01 3.000E-01 1.195E+01 9.733E-09 1.1955E+01 6.429182E-06 40 5.833E+01 1.183E+02 1.750E+01 3.000E-01 1.398E+01 9.733E-09 1.3982E+01 8.464798E-07 41 6.667E+01 1.267E+02 2.000E+01 3.000E-01 1.601E+01 9.733E-09 1.6010E+01 1.114493E-07 42 8.333E+01 1.433E+02 2.500E+01 3.000E-01 2.006E+01 9.733E-09 2.0065E+01 1.931965E-09 43 1.000E+02 1.600E+02 3.000E+01 3.000E-01 2.412E+01 9.733E-09 2.4120E+01 3.349045E-11 44 1.167E+02 1.767E+02 3.500E+01 3.000E-01 2.817E+01 9.733E-09 2.8175E+01 5.805542E-13 45 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 46 1.667E-01 7.217E+01 1.000E-01 6.000E-01 5.520E-02 1.076E-10 5.5201E-02 9.462948E-01 47 4.167E-01 7.242E+01 2.500E-01 6.000E-01 1.443E-01 2.608E-10 1.4429E-01 8.656381E-01 48 8.333E-01 7.283E+01 5.000E-01 6.000E-01 3.076E-01 1.631E-11 3.0764E-01 7.351770E-01 49 1.667E+00 7.367E+01 1.000E+00 6.000E-01 6.795E-01 1.278E-10 6.7950E-01 5.068713E-01 50 2.500E+00 7.450E+01 1.500E+00 6.000E-01 1.096E+00 0.000E+00 1.0962E+00 3.341496E-01 51 3.333E+00 7.533E+01 2.000E+00 6.000E-01 1.544E+00 0.000E+00 1.5441E+00 2.134946E-01 52 5.000E+00 7.700E+01 3.000E+00 6.000E-01 2.499E+00 0.000E+00 2.4992E+00 8.215154E-02 53 6.667E+00 6.667E+01 4.000E+00 6.000E-01 3.498E+00 1.667E-08 3.4985E+00 3.024343E-02 54 8.333E+00 6.833E+01 5.000E+00 6.000E-01 4.519E+00 1.718E-08 4.5194E+00 1.089515E-02 55 1.000E+01 7.000E+01 6.000E+00 6.000E-01 5.551E+00 1.743E-08 5.5510E+00 3.883480E-03 56 1.167E+01 7.167E+01 7.000E+00 6.000E-01 6.588E+00 1.756E-08 6.5878E+00 1.377039E-03 57 1.333E+01 7.333E+01 8.000E+00 6.000E-01 7.627E+00 1.762E-08 7.6272E+00 4.870372E-04 58 1.500E+01 7.500E+01 9.000E+00 6.000E-01 8.668E+00 1.765E-08 8.6678E+00 1.720417E-04 59 1.667E+01 7.667E+01 1.000E+01 6.000E-01 9.709E+00 1.766E-08 9.7090E+00 6.073492E-05 60 2.083E+01 8.083E+01 1.250E+01 6.000E-01 1.231E+01 1.767E-08 1.2313E+01 4.492765E-06 61 2.500E+01 8.500E+01 1.500E+01 6.000E-01 1.492E+01 1.768E-08 1.4917E+01 3.322140E-07 62 2.917E+01 8.917E+01 1.750E+01 6.000E-01 1.752E+01 1.768E-08 1.7522E+01 2.456368E-08 63 3.333E+01 9.333E+01 2.000E+01 6.000E-01 2.013E+01 1.768E-08 2.0127E+01 1.816202E-09 64 4.167E+01 1.017E+02 2.500E+01 6.000E-01 2.534E+01 1.768E-08 2.5336E+01 9.928955E-12 65 5.000E+01 1.100E+02 3.000E+01 6.000E-01 3.054E+01 1.768E-08 3.0545E+01 5.428038E-14 66 5.833E+01 1.183E+02 3.500E+01 6.000E-01 3.575E+01 1.768E-08 3.5754E+01 2.967441E-16 67 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 68 8.333E-02 7.208E+01 1.000E-01 1.200E+00 5.522E-02 1.077E-10 5.5219E-02 9.462781E-01 69 2.083E-01 7.221E+01 2.500E-01 1.200E+00 1.446E-01 2.670E-10 1.4455E-01 8.654100E-01 70 4.167E-01 7.242E+01 5.000E-01 1.200E+00 3.096E-01 2.876E-11 3.0961E-01 7.337331E-01 71 8.333E-01 7.283E+01 1.000E+00 1.200E+00 6.932E-01 1.687E-10 6.9323E-01 4.999592E-01 72 1.250E+00 7.325E+01 1.500E+00 1.200E+00 1.137E+00 0.000E+00 1.1368E+00 3.208376E-01 73 1.667E+00 7.367E+01 2.000E+00 1.200E+00 1.629E+00 0.000E+00 1.6291E+00 1.961108E-01 74 2.500E+00 7.450E+01 3.000E+00 1.200E+00 2.725E+00 0.000E+00 2.7248E+00 6.556001E-02 75 3.333E+00 7.533E+01 4.000E+00 1.200E+00 3.926E+00 0.000E+00 3.9262E+00 1.971771E-02 76 4.167E+00 7.617E+01 5.000E+00 1.200E+00 5.198E+00 0.000E+00 5.1978E+00 5.528768E-03 77 5.000E+00 7.700E+01 6.000E+00 1.200E+00 6.516E+00 7.229E-10 6.5159E+00 1.479725E-03 78 5.833E+00 6.583E+01 7.000E+00 1.200E+00 7.865E+00 2.761E-08 7.8650E+00 3.839652E-04 79 6.667E+00 6.667E+01 8.000E+00 1.200E+00 9.235E+00 2.816E-08 9.2346E+00 9.760220E-05 80 7.500E+00 6.750E+01 9.000E+00 1.200E+00 1.062E+01 2.853E-08 1.0618E+01 2.447229E-05 81 8.333E+00 6.833E+01 1.000E+01 1.200E+00 1.201E+01 2.877E-08 1.2010E+01 6.080319E-06 82 1.042E+01 7.042E+01 1.250E+01 1.200E+00 1.551E+01 2.909E-08 1.5514E+01 1.829583E-07 83 1.250E+01 7.250E+01 1.500E+01 1.200E+00 1.903E+01 2.920E-08 1.9032E+01 5.424517E-09 84 1.458E+01 7.458E+01 1.750E+01 1.200E+00 2.256E+01 2.924E-08 2.2556E+01 1.599726E-10 85 1.667E+01 7.667E+01 2.000E+01 1.200E+00 2.608E+01 2.926E-08 2.6082E+01 4.708557E-12 86 2.083E+01 8.083E+01 2.500E+01 1.200E+00 3.313E+01 2.927E-08 3.3135E+01 4.072411E-15 87 2.500E+01 8.500E+01 3.000E+01 1.200E+00 4.019E+01 2.927E-08 4.0188E+01 3.520548E-18 88 2.917E+01 8.917E+01 3.500E+01 1.200E+00 4.724E+01 2.927E-08 4.7241E+01 3.043280E-21 89 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 90 8.333E-03 7.201E+01 1.000E-01 1.200E+01 5.523E-02 1.078E-10 5.5235E-02 9.462629E-01 91 2.083E-02 7.202E+01 2.500E-01 1.200E+01 1.448E-01 2.734E-10 1.4480E-01 8.651974E-01 92 4.167E-02 7.204E+01 5.000E-01 1.200E+01 3.115E-01 4.084E-11 3.1151E-01 7.323430E-01 93 8.333E-02 7.208E+01 1.000E+00 1.200E+01 7.074E-01 0.000E+00 7.0738E-01 4.929344E-01 94 1.250E-01 7.212E+01 1.500E+00 1.200E+01 1.181E+00 0.000E+00 1.1815E+00 3.068312E-01 95 1.667E-01 7.217E+01 2.000E+00 1.200E+01 1.728E+00 0.000E+00 1.7282E+00 1.776115E-01 96 2.500E-01 7.225E+01 3.000E+00 1.200E+01 3.020E+00 7.647E-10 3.0196E+00 4.882261E-02 97 3.333E-01 7.233E+01 4.000E+00 1.200E+01 4.546E+00 8.596E-10 4.5461E+00 1.060865E-02 98 4.167E-01 7.242E+01 5.000E+00 1.200E+01 6.278E+00 9.227E-10 6.2780E+00 1.877225E-03 99 5.000E-01 7.250E+01 6.000E+00 1.200E+01 8.190E+00 9.747E-10 8.1900E+00 2.774097E-04 100 5.833E-01 7.258E+01 7.000E+00 1.200E+01 1.026E+01 1.036E-09 1.0261E+01 3.497759E-05 101 6.667E-01 7.267E+01 8.000E+00 1.200E+01 1.247E+01 1.089E-09 1.2472E+01 3.832741E-06 102 7.500E-01 7.275E+01 9.000E+00 1.200E+01 1.481E+01 1.145E-09 1.4808E+01 3.708289E-07 103 8.333E-01 7.283E+01 1.000E+01 1.200E+01 1.725E+01 1.160E-09 1.7254E+01 3.211898E-08 104 1.042E+00 7.304E+01 1.250E+01 1.200E+01 2.378E+01 1.240E-09 2.3779E+01 4.710095E-11 105 1.250E+00 7.325E+01 1.500E+01 1.200E+01 3.077E+01 1.302E-09 3.0774E+01 4.316740E-14 106 1.458E+00 7.346E+01 1.750E+01 1.200E+01 3.813E+01 1.348E-09 3.8128E+01 2.761130E-17 107 1.667E+00 7.367E+01 2.000E+01 1.200E+01 4.576E+01 1.383E-09 4.5760E+01 1.338215E-20 108 2.083E+00 6.208E+01 2.500E+01 1.200E+01 6.162E+01 8.689E-08 6.1623E+01 1.727272E-27 109 2.500E+00 6.250E+01 3.000E+01 1.200E+01 7.802E+01 8.962E-08 7.8021E+01 1.306378E-34 110 2.917E+00 6.292E+01 3.500E+01 1.200E+01 9.475E+01 9.132E-08 9.4748E+01 7.101845E-42 111 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 112 1.852E-03 7.200E+01 1.000E-01 5.400E+01 5.524E-02 1.078E-10 5.5236E-02 9.462616E-01 113 4.630E-03 7.200E+01 2.500E-01 5.400E+01 1.448E-01 2.740E-10 1.4482E-01 8.651787E-01 114 9.259E-03 7.201E+01 5.000E-01 5.400E+01 3.117E-01 4.186E-11 3.1168E-01 7.322187E-01 115 1.852E-02 7.202E+01 1.000E+00 5.400E+01 7.087E-01 0.000E+00 7.0869E-01 4.922880E-01 116 2.778E-02 7.203E+01 1.500E+00 5.400E+01 1.186E+00 0.000E+00 1.1857E+00 3.055205E-01 117 3.704E-02 7.204E+01 2.000E+00 5.400E+01 1.738E+00 0.000E+00 1.7380E+00 1.758764E-01 118 5.556E-02 7.206E+01 3.000E+00 5.400E+01 3.051E+00 7.794E-10 3.0507E+00 4.732806E-02 119 7.407E-02 7.207E+01 4.000E+00 5.400E+01 4.615E+00 8.748E-10 4.6154E+00 9.897808E-03 120 9.259E-02 7.209E+01 5.000E+00 5.400E+01 6.406E+00 9.329E-10 6.4058E+00 1.651971E-03 121 1.111E-01 7.211E+01 6.000E+00 5.400E+01 8.399E+00 1.013E-09 8.3989E+00 2.251045E-04 122 1.296E-01 7.213E+01 7.000E+00 5.400E+01 1.058E+01 1.084E-09 1.0575E+01 2.553896E-05 123 1.481E-01 7.215E+01 8.000E+00 5.400E+01 1.292E+01 1.155E-09 1.2918E+01 2.453912E-06 124 1.667E-01 7.217E+01 9.000E+00 5.400E+01 1.541E+01 1.185E-09 1.5412E+01 2.026839E-07 125 1.852E-01 7.219E+01 1.000E+01 5.400E+01 1.804E+01 1.234E-09 1.8044E+01 1.458037E-08 126 2.315E-01 7.223E+01 1.250E+01 5.400E+01 2.516E+01 1.341E-09 2.5155E+01 1.189037E-11 127 2.778E-01 7.228E+01 1.500E+01 5.400E+01 3.291E+01 1.431E-09 3.2913E+01 5.082231E-15 128 3.241E-01 7.232E+01 1.750E+01 5.400E+01 4.120E+01 1.500E-09 4.1204E+01 1.275058E-18 129 3.704E-01 7.237E+01 2.000E+01 5.400E+01 4.994E+01 1.557E-09 4.9939E+01 2.050571E-22 130 4.630E-01 7.246E+01 2.500E+01 5.400E+01 6.848E+01 1.644E-09 6.8478E+01 1.821683E-30 131 5.556E-01 6.056E+01 3.000E+01 5.400E+01 8.812E+01 1.120E-07 8.8117E+01 5.387341E-39 132 6.481E-01 6.065E+01 3.500E+01 5.400E+01 1.086E+02 1.166E-07 1.0858E+02 7.017405E-48 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 3.028E+00 1.000E-01 1.500E-01 9.4639E-01 9.4639E-01 1.0000E+00 9.4639E-01 9.4639E-01 9.4639E-01 3 3.069E+00 2.500E-01 1.500E-01 8.6685E-01 8.6685E-01 1.0000E+00 8.6685E-01 8.6685E-01 8.6685E-01 4 3.139E+00 5.000E-01 1.500E-01 7.4204E-01 7.4204E-01 1.0000E+00 7.4204E-01 7.4204E-01 7.4204E-01 5 3.278E+00 1.000E+00 1.500E-01 5.3459E-01 5.3459E-01 1.0000E+00 5.3459E-01 5.3459E-01 5.3459E-01 6 2.917E+00 1.500E+00 1.500E-01 3.8190E-01 3.8190E-01 1.0000E+00 3.8190E-01 3.8190E-01 3.8190E-01 7 3.056E+00 2.000E+00 1.500E-01 2.7217E-01 2.7217E-01 1.0000E+00 2.7217E-01 2.7217E-01 2.7217E-01 8 3.333E+00 3.000E+00 1.500E-01 1.3802E-01 1.3802E-01 1.0000E+00 1.3802E-01 1.3802E-01 1.3802E-01 9 3.611E+00 4.000E+00 1.500E-01 6.9967E-02 6.9967E-02 1.0000E+00 6.9967E-02 6.9967E-02 6.9967E-02 10 3.889E+00 5.000E+00 1.500E-01 3.5468E-02 3.5468E-02 1.0000E+00 3.5468E-02 3.5468E-02 3.5468E-02 11 4.167E+00 6.000E+00 1.500E-01 1.7980E-02 1.7980E-02 1.0000E+00 1.7980E-02 1.7980E-02 1.7980E-02 12 4.444E+00 7.000E+00 1.500E-01 9.1144E-03 9.1144E-03 1.0000E+00 9.1144E-03 9.1144E-03 9.1144E-03 13 4.722E+00 8.000E+00 1.500E-01 4.6203E-03 4.6203E-03 1.0000E+00 4.6203E-03 4.6203E-03 4.6203E-03 14 5.000E+00 9.000E+00 1.500E-01 2.3422E-03 2.3422E-03 1.0000E+00 2.3422E-03 2.3422E-03 2.3422E-03 15 5.278E+00 1.000E+01 1.500E-01 1.1873E-03 1.1873E-03 1.0000E+00 1.1873E-03 1.1873E-03 1.1873E-03 16 5.972E+00 1.250E+01 1.500E-01 2.1723E-04 2.1723E-04 1.0000E+00 2.1723E-04 2.1723E-04 2.1723E-04 17 6.667E+00 1.500E+01 1.500E-01 3.9745E-05 3.9745E-05 1.0000E+00 3.9745E-05 3.9745E-05 3.9745E-05 18 7.361E+00 1.750E+01 1.500E-01 7.2718E-06 7.2718E-06 1.0000E+00 7.2718E-06 7.2718E-06 7.2718E-06 19 8.056E+00 2.000E+01 1.500E-01 1.3305E-06 1.3305E-06 1.0000E+00 1.3305E-06 1.3305E-06 1.3305E-06 20 9.444E+00 2.500E+01 1.500E-01 4.4537E-08 4.4537E-08 1.0000E+00 4.4537E-08 4.4537E-08 4.4537E-08 21 1.083E+01 3.000E+01 1.500E-01 1.4909E-09 1.4909E-09 1.0000E+00 1.4909E-09 1.4909E-09 1.4909E-09 22 1.222E+01 3.500E+01 1.500E-01 4.9907E-11 4.9907E-11 1.0000E+00 4.9907E-11 4.9907E-11 4.9907E-11 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 3.014E+00 1.000E-01 3.000E-01 9.4633E-01 9.4633E-01 1.0000E+00 9.4633E-01 9.4633E-01 9.4633E-01 25 3.035E+00 2.500E-01 3.000E-01 8.6607E-01 8.6607E-01 1.0000E+00 8.6607E-01 8.6607E-01 8.6607E-01 26 3.069E+00 5.000E-01 3.000E-01 7.3778E-01 7.3778E-01 1.0000E+00 7.3778E-01 7.3778E-01 7.3778E-01 27 3.139E+00 1.000E+00 3.000E-01 5.1836E-01 5.1836E-01 1.0000E+00 5.1836E-01 5.1836E-01 5.1836E-01 28 3.208E+00 1.500E+00 3.000E-01 3.5509E-01 3.5509E-01 1.0000E+00 3.5509E-01 3.5509E-01 3.5509E-01 29 3.278E+00 2.000E+00 3.000E-01 2.4008E-01 2.4008E-01 1.0000E+00 2.4008E-01 2.4008E-01 2.4008E-01 30 2.917E+00 3.000E+00 3.000E-01 1.0789E-01 1.0789E-01 1.0000E+00 1.0789E-01 1.0789E-01 1.0789E-01 31 3.056E+00 4.000E+00 3.000E-01 4.8090E-02 4.8090E-02 1.0000E+00 4.8090E-02 4.8090E-02 4.8090E-02 32 3.194E+00 5.000E+00 3.000E-01 2.1389E-02 2.1389E-02 1.0000E+00 2.1389E-02 2.1389E-02 2.1389E-02 33 3.333E+00 6.000E+00 3.000E-01 9.5074E-03 9.5074E-03 1.0000E+00 9.5074E-03 9.5074E-03 9.5074E-03 34 3.472E+00 7.000E+00 3.000E-01 4.2254E-03 4.2254E-03 1.0000E+00 4.2254E-03 4.2254E-03 4.2254E-03 35 3.611E+00 8.000E+00 3.000E-01 1.8779E-03 1.8779E-03 1.0000E+00 1.8779E-03 1.8779E-03 1.8779E-03 36 3.750E+00 9.000E+00 3.000E-01 8.3454E-04 8.3454E-04 1.0000E+00 8.3454E-04 8.3454E-04 8.3454E-04 37 3.889E+00 1.000E+01 3.000E-01 3.7088E-04 3.7088E-04 1.0000E+00 3.7088E-04 3.7088E-04 3.7088E-04 38 4.236E+00 1.250E+01 3.000E-01 4.8831E-05 4.8831E-05 1.0000E+00 4.8831E-05 4.8831E-05 4.8831E-05 39 4.583E+00 1.500E+01 3.000E-01 6.4292E-06 6.4292E-06 1.0000E+00 6.4292E-06 6.4292E-06 6.4292E-06 40 4.931E+00 1.750E+01 3.000E-01 8.4648E-07 8.4648E-07 1.0000E+00 8.4648E-07 8.4648E-07 8.4648E-07 41 5.278E+00 2.000E+01 3.000E-01 1.1145E-07 1.1145E-07 1.0000E+00 1.1145E-07 1.1145E-07 1.1145E-07 42 5.972E+00 2.500E+01 3.000E-01 1.9320E-09 1.9320E-09 1.0000E+00 1.9320E-09 1.9320E-09 1.9320E-09 43 6.667E+00 3.000E+01 3.000E-01 3.3490E-11 3.3490E-11 1.0000E+00 3.3490E-11 3.3490E-11 3.3490E-11 44 7.361E+00 3.500E+01 3.000E-01 5.8055E-13 5.8055E-13 1.0000E+00 5.8055E-13 5.8055E-13 5.8055E-13 45 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 46 3.007E+00 1.000E-01 6.000E-01 9.4629E-01 9.4629E-01 1.0000E+00 9.4629E-01 9.4629E-01 9.4629E-01 47 3.017E+00 2.500E-01 6.000E-01 8.6564E-01 8.6564E-01 1.0000E+00 8.6564E-01 8.6564E-01 8.6564E-01 48 3.035E+00 5.000E-01 6.000E-01 7.3518E-01 7.3518E-01 1.0000E+00 7.3518E-01 7.3518E-01 7.3518E-01 49 3.069E+00 1.000E+00 6.000E-01 5.0687E-01 5.0687E-01 1.0000E+00 5.0687E-01 5.0687E-01 5.0687E-01 50 3.104E+00 1.500E+00 6.000E-01 3.3415E-01 3.3415E-01 1.0000E+00 3.3415E-01 3.3415E-01 3.3415E-01 51 3.139E+00 2.000E+00 6.000E-01 2.1349E-01 2.1349E-01 1.0000E+00 2.1349E-01 2.1349E-01 2.1349E-01 52 3.208E+00 3.000E+00 6.000E-01 8.2152E-02 8.2152E-02 1.0000E+00 8.2152E-02 8.2152E-02 8.2152E-02 53 2.778E+00 4.000E+00 6.000E-01 3.0243E-02 3.0243E-02 1.0000E+00 3.0243E-02 3.0243E-02 3.0243E-02 54 2.847E+00 5.000E+00 6.000E-01 1.0895E-02 1.0895E-02 1.0000E+00 1.0895E-02 1.0895E-02 1.0895E-02 55 2.917E+00 6.000E+00 6.000E-01 3.8835E-03 3.8835E-03 1.0000E+00 3.8835E-03 3.8835E-03 3.8835E-03 56 2.986E+00 7.000E+00 6.000E-01 1.3770E-03 1.3770E-03 1.0000E+00 1.3770E-03 1.3770E-03 1.3770E-03 57 3.056E+00 8.000E+00 6.000E-01 4.8704E-04 4.8704E-04 1.0000E+00 4.8704E-04 4.8704E-04 4.8704E-04 58 3.125E+00 9.000E+00 6.000E-01 1.7204E-04 1.7204E-04 1.0000E+00 1.7204E-04 1.7204E-04 1.7204E-04 59 3.194E+00 1.000E+01 6.000E-01 6.0735E-05 6.0735E-05 1.0000E+00 6.0735E-05 6.0735E-05 6.0735E-05 60 3.368E+00 1.250E+01 6.000E-01 4.4928E-06 4.4928E-06 1.0000E+00 4.4928E-06 4.4928E-06 4.4928E-06 61 3.542E+00 1.500E+01 6.000E-01 3.3221E-07 3.3221E-07 1.0000E+00 3.3221E-07 3.3221E-07 3.3221E-07 62 3.715E+00 1.750E+01 6.000E-01 2.4564E-08 2.4564E-08 1.0000E+00 2.4564E-08 2.4564E-08 2.4564E-08 63 3.889E+00 2.000E+01 6.000E-01 1.8162E-09 1.8162E-09 1.0000E+00 1.8162E-09 1.8162E-09 1.8162E-09 64 4.236E+00 2.500E+01 6.000E-01 9.9290E-12 9.9290E-12 1.0000E+00 9.9290E-12 9.9290E-12 9.9290E-12 65 4.583E+00 3.000E+01 6.000E-01 5.4280E-14 5.4280E-14 1.0000E+00 5.4280E-14 5.4280E-14 5.4280E-14 66 4.931E+00 3.500E+01 6.000E-01 2.9674E-16 2.9674E-16 1.0000E+00 2.9674E-16 2.9674E-16 2.9674E-16 67 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 68 3.003E+00 1.000E-01 1.200E+00 9.4628E-01 9.4628E-01 1.0000E+00 9.4628E-01 9.4628E-01 9.4628E-01 69 3.009E+00 2.500E-01 1.200E+00 8.6541E-01 8.6541E-01 1.0000E+00 8.6541E-01 8.6541E-01 8.6541E-01 70 3.017E+00 5.000E-01 1.200E+00 7.3373E-01 7.3373E-01 1.0000E+00 7.3373E-01 7.3373E-01 7.3373E-01 71 3.035E+00 1.000E+00 1.200E+00 4.9996E-01 4.9996E-01 1.0000E+00 4.9996E-01 4.9996E-01 4.9996E-01 72 3.052E+00 1.500E+00 1.200E+00 3.2084E-01 3.2084E-01 1.0000E+00 3.2084E-01 3.2084E-01 3.2084E-01 73 3.069E+00 2.000E+00 1.200E+00 1.9611E-01 1.9611E-01 1.0000E+00 1.9611E-01 1.9611E-01 1.9611E-01 74 3.104E+00 3.000E+00 1.200E+00 6.5560E-02 6.5560E-02 1.0000E+00 6.5560E-02 6.5560E-02 6.5560E-02 75 3.139E+00 4.000E+00 1.200E+00 1.9718E-02 1.9718E-02 1.0000E+00 1.9718E-02 1.9718E-02 1.9718E-02 76 3.174E+00 5.000E+00 1.200E+00 5.5288E-03 5.5288E-03 1.0000E+00 5.5288E-03 5.5288E-03 5.5288E-03 77 3.208E+00 6.000E+00 1.200E+00 1.4797E-03 1.4797E-03 1.0000E+00 1.4797E-03 1.4797E-03 1.4797E-03 78 2.743E+00 7.000E+00 1.200E+00 3.8397E-04 3.8397E-04 1.0000E+00 3.8397E-04 3.8397E-04 3.8397E-04 79 2.778E+00 8.000E+00 1.200E+00 9.7602E-05 9.7602E-05 1.0000E+00 9.7602E-05 9.7602E-05 9.7602E-05 80 2.812E+00 9.000E+00 1.200E+00 2.4472E-05 2.4472E-05 1.0000E+00 2.4472E-05 2.4472E-05 2.4472E-05 81 2.847E+00 1.000E+01 1.200E+00 6.0803E-06 6.0803E-06 1.0000E+00 6.0803E-06 6.0803E-06 6.0803E-06 82 2.934E+00 1.250E+01 1.200E+00 1.8296E-07 1.8296E-07 1.0000E+00 1.8296E-07 1.8296E-07 1.8296E-07 83 3.021E+00 1.500E+01 1.200E+00 5.4245E-09 5.4245E-09 1.0000E+00 5.4245E-09 5.4245E-09 5.4245E-09 84 3.108E+00 1.750E+01 1.200E+00 1.5997E-10 1.5997E-10 1.0000E+00 1.5997E-10 1.5997E-10 1.5997E-10 85 3.194E+00 2.000E+01 1.200E+00 4.7086E-12 4.7086E-12 1.0000E+00 4.7086E-12 4.7086E-12 4.7086E-12 86 3.368E+00 2.500E+01 1.200E+00 4.0724E-15 4.0724E-15 1.0000E+00 4.0724E-15 4.0724E-15 4.0724E-15 87 3.542E+00 3.000E+01 1.200E+00 3.5205E-18 3.5205E-18 1.0000E+00 3.5205E-18 3.5205E-18 3.5205E-18 88 3.715E+00 3.500E+01 1.200E+00 3.0433E-21 3.0433E-21 1.0000E+00 3.0433E-21 3.0433E-21 3.0433E-21 89 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 90 3.000E+00 1.000E-01 1.200E+01 9.4626E-01 9.4626E-01 1.0000E+00 9.4626E-01 9.4626E-01 9.4626E-01 91 3.001E+00 2.500E-01 1.200E+01 8.6520E-01 8.6520E-01 1.0000E+00 8.6520E-01 8.6520E-01 8.6520E-01 92 3.002E+00 5.000E-01 1.200E+01 7.3234E-01 7.3234E-01 1.0000E+00 7.3234E-01 7.3234E-01 7.3234E-01 93 3.003E+00 1.000E+00 1.200E+01 4.9293E-01 4.9293E-01 1.0000E+00 4.9293E-01 4.9293E-01 4.9293E-01 94 3.005E+00 1.500E+00 1.200E+01 3.0683E-01 3.0683E-01 1.0000E+00 3.0683E-01 3.0683E-01 3.0683E-01 95 3.007E+00 2.000E+00 1.200E+01 1.7761E-01 1.7761E-01 1.0000E+00 1.7761E-01 1.7761E-01 1.7761E-01 96 3.010E+00 3.000E+00 1.200E+01 4.8823E-02 4.8823E-02 1.0000E+00 4.8823E-02 4.8823E-02 4.8823E-02 97 3.014E+00 4.000E+00 1.200E+01 1.0609E-02 1.0609E-02 1.0000E+00 1.0609E-02 1.0609E-02 1.0609E-02 98 3.017E+00 5.000E+00 1.200E+01 1.8772E-03 1.8772E-03 1.0000E+00 1.8772E-03 1.8772E-03 1.8772E-03 99 3.021E+00 6.000E+00 1.200E+01 2.7741E-04 2.7741E-04 1.0000E+00 2.7741E-04 2.7741E-04 2.7741E-04 100 3.024E+00 7.000E+00 1.200E+01 3.4978E-05 3.4978E-05 1.0000E+00 3.4978E-05 3.4978E-05 3.4978E-05 101 3.028E+00 8.000E+00 1.200E+01 3.8327E-06 3.8327E-06 1.0000E+00 3.8327E-06 3.8327E-06 3.8327E-06 102 3.031E+00 9.000E+00 1.200E+01 3.7083E-07 3.7083E-07 1.0000E+00 3.7083E-07 3.7083E-07 3.7083E-07 103 3.035E+00 1.000E+01 1.200E+01 3.2119E-08 3.2119E-08 1.0000E+00 3.2119E-08 3.2119E-08 3.2119E-08 104 3.043E+00 1.250E+01 1.200E+01 4.7101E-11 4.7101E-11 1.0000E+00 4.7101E-11 4.7101E-11 4.7101E-11 105 3.052E+00 1.500E+01 1.200E+01 4.3167E-14 4.3167E-14 1.0000E+00 4.3167E-14 4.3167E-14 4.3167E-14 106 3.061E+00 1.750E+01 1.200E+01 2.7611E-17 2.7611E-17 1.0000E+00 2.7611E-17 2.7611E-17 2.7611E-17 107 3.069E+00 2.000E+01 1.200E+01 1.3382E-20 1.3382E-20 1.0000E+00 1.3382E-20 1.3382E-20 1.3382E-20 108 2.587E+00 2.500E+01 1.200E+01 1.7273E-27 1.7273E-27 1.0000E+00 1.7273E-27 1.7273E-27 1.7273E-27 109 2.604E+00 3.000E+01 1.200E+01 1.3064E-34 1.3064E-34 1.0000E+00 1.3064E-34 1.3064E-34 1.3064E-34 110 2.622E+00 3.500E+01 1.200E+01 7.1018E-42 7.1018E-42 1.0000E+00 7.1018E-42 7.1018E-42 7.1018E-42 111 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 112 3.000E+00 1.000E-01 5.400E+01 9.4626E-01 9.4626E-01 1.0000E+00 9.4626E-01 9.4626E-01 9.4626E-01 113 3.000E+00 2.500E-01 5.400E+01 8.6518E-01 8.6518E-01 1.0000E+00 8.6518E-01 8.6518E-01 8.6518E-01 114 3.000E+00 5.000E-01 5.400E+01 7.3222E-01 7.3222E-01 1.0000E+00 7.3222E-01 7.3222E-01 7.3222E-01 115 3.001E+00 1.000E+00 5.400E+01 4.9229E-01 4.9229E-01 1.0000E+00 4.9229E-01 4.9229E-01 4.9229E-01 116 3.001E+00 1.500E+00 5.400E+01 3.0552E-01 3.0552E-01 1.0000E+00 3.0552E-01 3.0552E-01 3.0552E-01 117 3.002E+00 2.000E+00 5.400E+01 1.7588E-01 1.7588E-01 1.0000E+00 1.7588E-01 1.7588E-01 1.7588E-01 118 3.002E+00 3.000E+00 5.400E+01 4.7328E-02 4.7328E-02 1.0000E+00 4.7328E-02 4.7328E-02 4.7328E-02 119 3.003E+00 4.000E+00 5.400E+01 9.8978E-03 9.8978E-03 1.0000E+00 9.8978E-03 9.8978E-03 9.8978E-03 120 3.004E+00 5.000E+00 5.400E+01 1.6520E-03 1.6520E-03 1.0000E+00 1.6520E-03 1.6520E-03 1.6520E-03 121 3.005E+00 6.000E+00 5.400E+01 2.2510E-04 2.2510E-04 1.0000E+00 2.2510E-04 2.2510E-04 2.2510E-04 122 3.005E+00 7.000E+00 5.400E+01 2.5539E-05 2.5539E-05 1.0000E+00 2.5539E-05 2.5539E-05 2.5539E-05 123 3.006E+00 8.000E+00 5.400E+01 2.4539E-06 2.4539E-06 1.0000E+00 2.4539E-06 2.4539E-06 2.4539E-06 124 3.007E+00 9.000E+00 5.400E+01 2.0268E-07 2.0268E-07 1.0000E+00 2.0268E-07 2.0268E-07 2.0268E-07 125 3.008E+00 1.000E+01 5.400E+01 1.4580E-08 1.4580E-08 1.0000E+00 1.4580E-08 1.4580E-08 1.4580E-08 126 3.010E+00 1.250E+01 5.400E+01 1.1890E-11 1.1890E-11 1.0000E+00 1.1890E-11 1.1890E-11 1.1890E-11 127 3.012E+00 1.500E+01 5.400E+01 5.0822E-15 5.0822E-15 1.0000E+00 5.0822E-15 5.0822E-15 5.0822E-15 128 3.014E+00 1.750E+01 5.400E+01 1.2751E-18 1.2751E-18 1.0000E+00 1.2751E-18 1.2751E-18 1.2751E-18 129 3.015E+00 2.000E+01 5.400E+01 2.0506E-22 2.0506E-22 1.0000E+00 2.0506E-22 2.0506E-22 2.0506E-22 130 3.019E+00 2.500E+01 5.400E+01 1.8217E-30 1.8217E-30 1.0000E+00 1.8217E-30 1.8217E-30 1.8217E-30 131 2.523E+00 3.000E+01 5.400E+01 5.3873E-39 5.3873E-39 1.0000E+00 5.3873E-39 5.3873E-39 5.3873E-39 132 2.527E+00 3.500E+01 5.400E+01 7.0174E-48 7.0174E-48 1.0000E+00 7.0174E-48 7.0174E-48 7.0174E-48 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 1.500E-01 2.445E+00 0.00E+00 2.44490E+00 9.834E-06 9.834E-06 1.039E-05 3 2.500E-01 1.500E-01 6.107E+00 0.00E+00 6.10711E+00 2.250E-05 2.250E-05 2.595E-05 4 5.000E-01 1.500E-01 1.220E+01 0.00E+00 1.22017E+01 3.848E-05 3.848E-05 5.186E-05 5 1.000E+00 1.500E-01 2.437E+01 0.00E+00 2.43737E+01 5.537E-05 5.537E-05 1.036E-04 6 1.500E+00 1.500E-01 3.654E+01 0.00E+00 3.65374E+01 5.930E-05 5.930E-05 1.553E-04 7 2.000E+00 1.500E-01 4.870E+01 0.00E+00 4.86987E+01 5.633E-05 5.633E-05 2.069E-04 8 3.000E+00 1.500E-01 7.302E+01 0.00E+00 7.30196E+01 4.283E-05 4.283E-05 3.103E-04 9 4.000E+00 1.500E-01 9.734E+01 0.00E+00 9.73403E+01 2.894E-05 2.894E-05 4.136E-04 10 5.000E+00 1.500E-01 1.217E+02 0.00E+00 1.21661E+02 1.833E-05 1.833E-05 5.169E-04 11 6.000E+00 1.500E-01 1.460E+02 0.00E+00 1.45981E+02 1.115E-05 1.115E-05 6.202E-04 12 7.000E+00 1.500E-01 1.703E+02 0.00E+00 1.70302E+02 6.594E-06 6.594E-06 7.235E-04 13 8.000E+00 1.500E-01 1.946E+02 0.00E+00 1.94623E+02 3.820E-06 3.820E-06 8.268E-04 14 9.000E+00 1.500E-01 2.189E+02 0.00E+00 2.18943E+02 2.178E-06 2.178E-06 9.301E-04 15 1.000E+01 1.500E-01 2.433E+02 0.00E+00 2.43264E+02 1.227E-06 1.227E-06 1.033E-03 16 1.250E+01 1.500E-01 3.041E+02 0.00E+00 3.04065E+02 2.805E-07 2.805E-07 1.291E-03 17 1.500E+01 1.500E-01 3.649E+02 0.00E+00 3.64867E+02 6.158E-08 6.158E-08 1.549E-03 18 1.750E+01 1.500E-01 4.257E+02 0.00E+00 4.25668E+02 1.314E-08 1.314E-08 1.807E-03 19 2.000E+01 1.500E-01 4.865E+02 0.00E+00 4.86470E+02 2.748E-09 2.748E-09 2.065E-03 20 2.500E+01 1.500E-01 6.081E+02 0.00E+00 6.08073E+02 1.149E-10 1.149E-10 2.581E-03 21 3.000E+01 1.500E-01 7.297E+02 0.00E+00 7.29676E+02 4.616E-12 4.616E-12 3.096E-03 22 3.500E+01 1.500E-01 8.513E+02 0.00E+00 8.51279E+02 1.802E-13 1.802E-13 3.611E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 3.000E-01 2.445E+00 0.00E+00 2.44483E+00 9.833E-06 9.833E-06 1.039E-05 25 2.500E-01 3.000E-01 6.106E+00 0.00E+00 6.10621E+00 2.248E-05 2.248E-05 2.595E-05 26 5.000E-01 3.000E-01 1.220E+01 0.00E+00 1.21959E+01 3.824E-05 3.824E-05 5.183E-05 27 1.000E+00 3.000E-01 2.434E+01 0.00E+00 2.43429E+01 5.363E-05 5.363E-05 1.035E-04 28 1.500E+00 3.000E-01 3.646E+01 0.00E+00 3.64646E+01 5.503E-05 5.503E-05 1.550E-04 29 2.000E+00 3.000E-01 4.857E+01 0.00E+00 4.85732E+01 4.956E-05 4.956E-05 2.064E-04 30 3.000E+00 3.000E-01 7.277E+01 0.00E+00 7.27733E+01 3.336E-05 3.336E-05 3.092E-04 31 4.000E+00 3.000E-01 9.697E+01 0.00E+00 9.69653E+01 1.981E-05 1.981E-05 4.120E-04 32 5.000E+00 3.000E-01 1.212E+02 0.00E+00 1.21155E+02 1.101E-05 1.101E-05 5.148E-04 33 6.000E+00 3.000E-01 1.453E+02 0.00E+00 1.45344E+02 5.871E-06 5.871E-06 6.175E-04 34 7.000E+00 3.000E-01 1.695E+02 0.00E+00 1.69533E+02 3.043E-06 3.043E-06 7.203E-04 35 8.000E+00 3.000E-01 1.937E+02 0.00E+00 1.93722E+02 1.545E-06 1.545E-06 8.230E-04 36 9.000E+00 3.000E-01 2.179E+02 0.00E+00 2.17911E+02 7.725E-07 7.725E-07 9.257E-04 37 1.000E+01 3.000E-01 2.421E+02 0.00E+00 2.42100E+02 3.814E-07 3.814E-07 1.028E-03 38 1.250E+01 3.000E-01 3.026E+02 0.00E+00 3.02573E+02 6.275E-08 6.275E-08 1.285E-03 39 1.500E+01 3.000E-01 3.630E+02 0.00E+00 3.63045E+02 9.912E-09 9.912E-09 1.542E-03 40 1.750E+01 3.000E-01 4.235E+02 0.00E+00 4.23518E+02 1.522E-09 1.522E-09 1.798E-03 41 2.000E+01 3.000E-01 4.840E+02 0.00E+00 4.83990E+02 2.290E-10 2.290E-10 2.055E-03 42 2.500E+01 3.000E-01 6.049E+02 0.00E+00 6.04935E+02 4.961E-12 4.961E-12 2.568E-03 43 3.000E+01 3.000E-01 7.259E+02 0.00E+00 7.25880E+02 1.032E-13 1.032E-13 3.080E-03 44 3.500E+01 3.000E-01 8.468E+02 0.00E+00 8.46825E+02 2.086E-15 2.086E-15 3.593E-03 45 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 46 1.000E-01 6.000E-01 2.445E+00 0.00E+00 2.44480E+00 9.832E-06 9.832E-06 1.039E-05 47 2.500E-01 6.000E-01 6.106E+00 0.00E+00 6.10571E+00 2.246E-05 2.246E-05 2.595E-05 48 5.000E-01 6.000E-01 1.219E+01 0.00E+00 1.21924E+01 3.809E-05 3.809E-05 5.182E-05 49 1.000E+00 6.000E-01 2.432E+01 0.00E+00 2.43205E+01 5.239E-05 5.239E-05 1.034E-04 50 1.500E+00 6.000E-01 3.640E+01 0.00E+00 3.64038E+01 5.169E-05 5.169E-05 1.547E-04 51 2.000E+00 6.000E-01 4.846E+01 0.00E+00 4.84559E+01 4.396E-05 4.396E-05 2.059E-04 52 3.000E+00 6.000E-01 7.250E+01 0.00E+00 7.25008E+01 2.531E-05 2.531E-05 3.081E-04 53 4.000E+00 6.000E-01 9.650E+01 0.00E+00 9.65015E+01 1.240E-05 1.240E-05 4.100E-04 54 5.000E+00 6.000E-01 1.205E+02 0.00E+00 1.20481E+02 5.577E-06 5.577E-06 5.119E-04 55 6.000E+00 6.000E-01 1.444E+02 0.00E+00 1.44449E+02 2.383E-06 2.383E-06 6.137E-04 56 7.000E+00 6.000E-01 1.684E+02 0.00E+00 1.68412E+02 9.853E-07 9.853E-07 7.155E-04 57 8.000E+00 6.000E-01 1.924E+02 0.00E+00 1.92373E+02 3.980E-07 3.980E-07 8.173E-04 58 9.000E+00 6.000E-01 2.163E+02 0.00E+00 2.16332E+02 1.581E-07 1.581E-07 9.190E-04 59 1.000E+01 6.000E-01 2.403E+02 0.00E+00 2.40291E+02 6.199E-08 6.199E-08 1.021E-03 60 1.250E+01 6.000E-01 3.002E+02 0.00E+00 3.00187E+02 5.728E-09 5.728E-09 1.275E-03 61 1.500E+01 6.000E-01 3.601E+02 0.00E+00 3.60083E+02 5.080E-10 5.080E-10 1.529E-03 62 1.750E+01 6.000E-01 4.200E+02 0.00E+00 4.19978E+02 4.380E-11 4.380E-11 1.783E-03 63 2.000E+01 6.000E-01 4.799E+02 0.00E+00 4.79873E+02 3.700E-12 3.700E-12 2.037E-03 64 2.500E+01 6.000E-01 5.997E+02 0.00E+00 5.99664E+02 2.527E-14 2.527E-14 2.545E-03 65 3.000E+01 6.000E-01 7.195E+02 0.00E+00 7.19455E+02 1.657E-16 1.657E-16 3.053E-03 66 3.500E+01 6.000E-01 8.392E+02 0.00E+00 8.39246E+02 1.057E-18 1.057E-18 3.560E-03 67 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 68 1.000E-01 1.200E+00 2.445E+00 0.00E+00 2.44478E+00 9.832E-06 9.832E-06 1.039E-05 69 2.500E-01 1.200E+00 6.105E+00 0.00E+00 6.10545E+00 2.246E-05 2.246E-05 2.595E-05 70 5.000E-01 1.200E+00 1.219E+01 0.00E+00 1.21904E+01 3.801E-05 3.801E-05 5.181E-05 71 1.000E+00 1.200E+00 2.431E+01 0.00E+00 2.43068E+01 5.165E-05 5.165E-05 1.033E-04 72 1.500E+00 1.200E+00 3.636E+01 0.00E+00 3.63632E+01 4.958E-05 4.958E-05 1.545E-04 73 2.000E+00 1.200E+00 4.837E+01 0.00E+00 4.83709E+01 4.031E-05 4.031E-05 2.056E-04 74 3.000E+00 1.200E+00 7.228E+01 0.00E+00 7.22752E+01 2.013E-05 2.013E-05 3.071E-04 75 4.000E+00 1.200E+00 9.607E+01 0.00E+00 9.60738E+01 8.049E-06 8.049E-06 4.082E-04 76 5.000E+00 1.200E+00 1.198E+02 0.00E+00 1.19802E+02 2.814E-06 2.814E-06 5.090E-04 77 6.000E+00 1.200E+00 1.435E+02 0.00E+00 1.43484E+02 9.021E-07 9.021E-07 6.096E-04 78 7.000E+00 1.200E+00 1.671E+02 0.00E+00 1.67135E+02 2.726E-07 2.726E-07 7.101E-04 79 8.000E+00 1.200E+00 1.908E+02 0.00E+00 1.90765E+02 7.910E-08 7.910E-08 8.104E-04 80 9.000E+00 1.200E+00 2.144E+02 0.00E+00 2.14382E+02 2.229E-08 2.229E-08 9.107E-04 81 1.000E+01 1.200E+00 2.380E+02 0.00E+00 2.37990E+02 6.147E-09 6.147E-09 1.011E-03 82 1.250E+01 1.200E+00 2.970E+02 0.00E+00 2.96986E+02 2.308E-10 2.308E-10 1.261E-03 83 1.500E+01 1.200E+00 3.560E+02 0.00E+00 3.55968E+02 8.200E-12 8.200E-12 1.512E-03 84 1.750E+01 1.200E+00 4.149E+02 0.00E+00 4.14944E+02 2.819E-13 2.819E-13 1.762E-03 85 2.000E+01 1.200E+00 4.739E+02 0.00E+00 4.73918E+02 9.474E-15 9.474E-15 2.012E-03 86 2.500E+01 1.200E+00 5.919E+02 0.00E+00 5.91865E+02 1.023E-17 1.023E-17 2.512E-03 87 3.000E+01 1.200E+00 7.098E+02 0.00E+00 7.09812E+02 1.060E-20 1.060E-20 3.012E-03 88 3.500E+01 1.200E+00 8.278E+02 0.00E+00 8.27759E+02 1.069E-23 1.069E-23 3.512E-03 89 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 90 1.000E-01 1.200E+01 2.445E+00 0.00E+00 2.44477E+00 9.832E-06 9.832E-06 1.039E-05 91 2.500E-01 1.200E+01 6.105E+00 0.00E+00 6.10520E+00 2.245E-05 2.245E-05 2.595E-05 92 5.000E-01 1.200E+01 1.219E+01 0.00E+00 1.21885E+01 3.794E-05 3.794E-05 5.180E-05 93 1.000E+00 1.200E+01 2.429E+01 0.00E+00 2.42926E+01 5.089E-05 5.089E-05 1.032E-04 94 1.500E+00 1.200E+01 3.632E+01 0.00E+00 3.63185E+01 4.736E-05 4.736E-05 1.543E-04 95 2.000E+00 1.200E+01 4.827E+01 0.00E+00 4.82718E+01 3.643E-05 3.643E-05 2.051E-04 96 3.000E+00 1.200E+01 7.198E+01 0.00E+00 7.19804E+01 1.493E-05 1.493E-05 3.059E-04 97 4.000E+00 1.200E+01 9.545E+01 0.00E+00 9.54539E+01 4.303E-06 4.303E-06 4.056E-04 98 5.000E+00 1.200E+01 1.187E+02 0.00E+00 1.18722E+02 9.469E-07 9.469E-07 5.044E-04 99 6.000E+00 1.200E+01 1.418E+02 0.00E+00 1.41810E+02 1.671E-07 1.671E-07 6.025E-04 100 7.000E+00 1.200E+01 1.647E+02 0.00E+00 1.64739E+02 2.448E-08 2.448E-08 6.999E-04 101 8.000E+00 1.200E+01 1.875E+02 0.00E+00 1.87528E+02 3.053E-09 3.053E-09 7.967E-04 102 9.000E+00 1.200E+01 2.102E+02 0.00E+00 2.10192E+02 3.311E-10 3.311E-10 8.929E-04 103 1.000E+01 1.200E+01 2.327E+02 0.00E+00 2.32746E+02 3.176E-11 3.176E-11 9.887E-04 104 1.250E+01 1.200E+01 2.887E+02 0.00E+00 2.88721E+02 5.776E-14 5.776E-14 1.226E-03 105 1.500E+01 1.200E+01 3.442E+02 0.00E+00 3.44226E+02 6.311E-17 6.311E-17 1.462E-03 106 1.750E+01 1.200E+01 3.994E+02 0.00E+00 3.99372E+02 4.683E-20 4.683E-20 1.696E-03 107 2.000E+01 1.200E+01 4.542E+02 0.00E+00 4.54240E+02 2.581E-23 2.581E-23 1.929E-03 108 2.500E+01 1.200E+01 5.634E+02 0.00E+00 5.63377E+02 4.131E-30 4.131E-30 2.391E-03 109 3.000E+01 1.200E+01 6.720E+02 0.00E+00 6.71979E+02 3.726E-37 3.726E-37 2.852E-03 110 3.500E+01 1.200E+01 7.803E+02 0.00E+00 7.80252E+02 2.351E-44 2.351E-44 3.311E-03 111 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 112 1.000E-01 5.400E+01 2.445E+00 0.00E+00 2.44476E+00 9.832E-06 9.832E-06 1.039E-05 113 2.500E-01 5.400E+01 6.105E+00 0.00E+00 6.10518E+00 2.245E-05 2.245E-05 2.595E-05 114 5.000E-01 5.400E+01 1.219E+01 0.00E+00 1.21883E+01 3.793E-05 3.793E-05 5.180E-05 115 1.000E+00 5.400E+01 2.429E+01 0.00E+00 2.42913E+01 5.082E-05 5.082E-05 1.032E-04 116 1.500E+00 5.400E+01 3.631E+01 0.00E+00 3.63143E+01 4.715E-05 4.715E-05 1.543E-04 117 2.000E+00 5.400E+01 4.826E+01 0.00E+00 4.82620E+01 3.607E-05 3.607E-05 2.051E-04 118 3.000E+00 5.400E+01 7.195E+01 0.00E+00 7.19493E+01 1.447E-05 1.447E-05 3.057E-04 119 4.000E+00 5.400E+01 9.538E+01 0.00E+00 9.53846E+01 4.012E-06 4.012E-06 4.053E-04 120 5.000E+00 5.400E+01 1.186E+02 0.00E+00 1.18594E+02 8.324E-07 8.324E-07 5.039E-04 121 6.000E+00 5.400E+01 1.416E+02 0.00E+00 1.41601E+02 1.354E-07 1.354E-07 6.016E-04 122 7.000E+00 5.400E+01 1.644E+02 0.00E+00 1.64425E+02 1.784E-08 1.784E-08 6.986E-04 123 8.000E+00 5.400E+01 1.871E+02 0.00E+00 1.87082E+02 1.950E-09 1.950E-09 7.948E-04 124 9.000E+00 5.400E+01 2.096E+02 0.00E+00 2.09588E+02 1.805E-10 1.805E-10 8.904E-04 125 1.000E+01 5.400E+01 2.320E+02 0.00E+00 2.31956E+02 1.437E-11 1.437E-11 9.853E-04 126 1.250E+01 5.400E+01 2.873E+02 0.00E+00 2.87345E+02 1.451E-14 1.451E-14 1.220E-03 127 1.500E+01 5.400E+01 3.421E+02 0.00E+00 3.42087E+02 7.384E-18 7.384E-18 1.453E-03 128 1.750E+01 5.400E+01 3.963E+02 0.00E+00 3.96296E+02 2.146E-21 2.146E-21 1.683E-03 129 2.000E+01 5.400E+01 4.501E+02 0.00E+00 4.50061E+02 3.919E-25 3.919E-25 1.911E-03 130 2.500E+01 5.400E+01 5.565E+02 0.00E+00 5.56522E+02 4.304E-33 4.304E-33 2.362E-03 131 3.000E+01 5.400E+01 6.619E+02 0.00E+00 6.61883E+02 1.513E-41 1.513E-41 2.809E-03 132 3.500E+01 5.400E+01 7.664E+02 0.00E+00 7.66424E+02 2.282E-50 2.282E-50 3.252E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 1.500E-01 2.445E+00 9.834E-06 1.039E-05 6.8995E-05 6.9118E-05 6.5413E-05 3 2.500E-01 1.500E-01 6.107E+00 2.250E-05 2.595E-05 6.8993E-05 6.9303E-05 6.0075E-05 4 5.000E-01 1.500E-01 1.220E+01 3.848E-05 5.186E-05 6.8992E-05 6.9610E-05 5.1654E-05 5 1.000E+00 1.500E-01 2.437E+01 5.537E-05 1.036E-04 6.8988E-05 7.0224E-05 3.7541E-05 6 1.500E+00 1.500E-01 3.654E+01 5.930E-05 1.553E-04 6.8985E-05 7.0837E-05 2.7053E-05 7 2.000E+00 1.500E-01 4.870E+01 5.633E-05 2.069E-04 6.8981E-05 7.1449E-05 1.9446E-05 8 3.000E+00 1.500E-01 7.302E+01 4.283E-05 3.103E-04 6.8974E-05 7.2675E-05 1.0031E-05 9 4.000E+00 1.500E-01 9.734E+01 2.894E-05 4.136E-04 6.8967E-05 7.3900E-05 5.1706E-06 10 5.000E+00 1.500E-01 1.217E+02 1.833E-05 5.169E-04 6.8960E-05 7.5126E-05 2.6646E-06 11 6.000E+00 1.500E-01 1.460E+02 1.115E-05 6.202E-04 6.8952E-05 7.6351E-05 1.3728E-06 12 7.000E+00 1.500E-01 1.703E+02 6.594E-06 7.235E-04 6.8945E-05 7.7576E-05 7.0706E-07 13 8.000E+00 1.500E-01 1.946E+02 3.820E-06 8.268E-04 6.8938E-05 7.8801E-05 3.6408E-07 14 9.000E+00 1.500E-01 2.189E+02 2.178E-06 9.301E-04 6.8931E-05 8.0025E-05 1.8743E-07 15 1.000E+01 1.500E-01 2.433E+02 1.227E-06 1.033E-03 6.8924E-05 8.1250E-05 9.6468E-08 16 1.250E+01 1.500E-01 3.041E+02 2.805E-07 1.291E-03 6.8906E-05 8.4311E-05 1.8315E-08 17 1.500E+01 1.500E-01 3.649E+02 6.158E-08 1.549E-03 6.8888E-05 8.7371E-05 3.4725E-09 18 1.750E+01 1.500E-01 4.257E+02 1.314E-08 1.807E-03 6.8871E-05 9.0430E-05 6.5759E-10 19 2.000E+01 1.500E-01 4.865E+02 2.748E-09 2.065E-03 6.8853E-05 9.3489E-05 1.2438E-10 20 2.500E+01 1.500E-01 6.081E+02 1.149E-10 2.581E-03 6.8817E-05 9.9604E-05 4.4361E-12 21 3.000E+01 1.500E-01 7.297E+02 4.616E-12 3.096E-03 6.8782E-05 1.0572E-04 1.5761E-13 22 3.500E+01 1.500E-01 8.513E+02 1.802E-13 3.611E-03 6.8746E-05 1.1182E-04 5.5808E-15 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 3.000E-01 2.445E+00 9.833E-06 1.039E-05 6.8995E-05 6.9118E-05 6.5409E-05 25 2.500E-01 3.000E-01 6.106E+00 2.248E-05 2.595E-05 6.8993E-05 6.9303E-05 6.0021E-05 26 5.000E-01 3.000E-01 1.220E+01 3.824E-05 5.183E-05 6.8992E-05 6.9610E-05 5.1357E-05 27 1.000E+00 3.000E-01 2.434E+01 5.363E-05 1.035E-04 6.8988E-05 7.0222E-05 3.6400E-05 28 1.500E+00 3.000E-01 3.646E+01 5.503E-05 1.550E-04 6.8985E-05 7.0833E-05 2.5152E-05 29 2.000E+00 3.000E-01 4.857E+01 4.956E-05 2.064E-04 6.8981E-05 7.1443E-05 1.7152E-05 30 3.000E+00 3.000E-01 7.277E+01 3.336E-05 3.092E-04 6.8974E-05 7.2663E-05 7.8394E-06 31 4.000E+00 3.000E-01 9.697E+01 1.981E-05 4.120E-04 6.8967E-05 7.3881E-05 3.5529E-06 32 5.000E+00 3.000E-01 1.212E+02 1.101E-05 5.148E-04 6.8960E-05 7.5100E-05 1.6063E-06 33 6.000E+00 3.000E-01 1.453E+02 5.871E-06 6.175E-04 6.8953E-05 7.6319E-05 7.2559E-07 34 7.000E+00 3.000E-01 1.695E+02 3.043E-06 7.203E-04 6.8946E-05 7.7537E-05 3.2763E-07 35 8.000E+00 3.000E-01 1.937E+02 1.545E-06 8.230E-04 6.8938E-05 7.8755E-05 1.4789E-07 36 9.000E+00 3.000E-01 2.179E+02 7.725E-07 9.257E-04 6.8931E-05 7.9973E-05 6.6741E-08 37 1.000E+01 3.000E-01 2.421E+02 3.814E-07 1.028E-03 6.8924E-05 8.1191E-05 3.0112E-08 38 1.250E+01 3.000E-01 3.026E+02 6.275E-08 1.285E-03 6.8907E-05 8.4236E-05 4.1133E-09 39 1.500E+01 3.000E-01 3.630E+02 9.912E-09 1.542E-03 6.8889E-05 8.7279E-05 5.6113E-10 40 1.750E+01 3.000E-01 4.235E+02 1.522E-09 1.798E-03 6.8871E-05 9.0322E-05 7.6456E-11 41 2.000E+01 3.000E-01 4.840E+02 2.290E-10 2.055E-03 6.8853E-05 9.3364E-05 1.0405E-11 42 2.500E+01 3.000E-01 6.049E+02 4.961E-12 2.568E-03 6.8818E-05 9.9446E-05 1.9213E-13 43 3.000E+01 3.000E-01 7.259E+02 1.032E-13 3.080E-03 6.8783E-05 1.0552E-04 3.5341E-15 44 3.500E+01 3.000E-01 8.468E+02 2.086E-15 3.593E-03 6.8747E-05 1.1160E-04 6.4790E-17 45 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 46 1.000E-01 6.000E-01 2.445E+00 9.832E-06 1.039E-05 6.8995E-05 6.9118E-05 6.5406E-05 47 2.500E-01 6.000E-01 6.106E+00 2.246E-05 2.595E-05 6.8993E-05 6.9303E-05 5.9991E-05 48 5.000E-01 6.000E-01 1.219E+01 3.809E-05 5.182E-05 6.8992E-05 6.9610E-05 5.1175E-05 49 1.000E+00 6.000E-01 2.432E+01 5.239E-05 1.034E-04 6.8988E-05 7.0221E-05 3.5593E-05 50 1.500E+00 6.000E-01 3.640E+01 5.169E-05 1.547E-04 6.8985E-05 7.0830E-05 2.3668E-05 51 2.000E+00 6.000E-01 4.846E+01 4.396E-05 2.059E-04 6.8981E-05 7.1437E-05 1.5251E-05 52 3.000E+00 6.000E-01 7.250E+01 2.531E-05 3.081E-04 6.8974E-05 7.2649E-05 5.9682E-06 53 4.000E+00 6.000E-01 9.650E+01 1.240E-05 4.100E-04 6.8967E-05 7.3858E-05 2.2337E-06 54 5.000E+00 6.000E-01 1.205E+02 5.577E-06 5.119E-04 6.8960E-05 7.5066E-05 8.1786E-07 55 6.000E+00 6.000E-01 1.444E+02 2.383E-06 6.137E-04 6.8953E-05 7.6274E-05 2.9621E-07 56 7.000E+00 6.000E-01 1.684E+02 9.853E-07 7.155E-04 6.8946E-05 7.7480E-05 1.0669E-07 57 8.000E+00 6.000E-01 1.924E+02 3.980E-07 8.173E-04 6.8939E-05 7.8687E-05 3.8324E-08 58 9.000E+00 6.000E-01 2.163E+02 1.581E-07 9.190E-04 6.8932E-05 7.9894E-05 1.3745E-08 59 1.000E+01 6.000E-01 2.403E+02 6.199E-08 1.021E-03 6.8925E-05 8.1100E-05 4.9256E-09 60 1.250E+01 6.000E-01 3.002E+02 5.728E-09 1.275E-03 6.8907E-05 8.4116E-05 3.7791E-10 61 1.500E+01 6.000E-01 3.601E+02 5.080E-10 1.529E-03 6.8890E-05 8.7130E-05 2.8946E-11 62 1.750E+01 6.000E-01 4.200E+02 4.380E-11 1.783E-03 6.8872E-05 9.0144E-05 2.2143E-12 63 2.000E+01 6.000E-01 4.799E+02 3.700E-12 2.037E-03 6.8855E-05 9.3157E-05 1.6919E-13 64 2.500E+01 6.000E-01 5.997E+02 2.527E-14 2.545E-03 6.8820E-05 9.9181E-05 9.8476E-16 65 3.000E+01 6.000E-01 7.195E+02 1.657E-16 3.053E-03 6.8785E-05 1.0520E-04 5.7104E-18 66 3.500E+01 6.000E-01 8.392E+02 1.057E-18 3.560E-03 6.8750E-05 1.1122E-04 3.3004E-20 67 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 68 1.000E-01 1.200E+00 2.445E+00 9.832E-06 1.039E-05 6.8995E-05 6.9118E-05 6.5405E-05 69 2.500E-01 1.200E+00 6.105E+00 2.246E-05 2.595E-05 6.8993E-05 6.9303E-05 5.9975E-05 70 5.000E-01 1.200E+00 1.219E+01 3.801E-05 5.181E-05 6.8992E-05 6.9610E-05 5.1075E-05 71 1.000E+00 1.200E+00 2.431E+01 5.165E-05 1.033E-04 6.8988E-05 7.0220E-05 3.5107E-05 72 1.500E+00 1.200E+00 3.636E+01 4.958E-05 1.545E-04 6.8985E-05 7.0828E-05 2.2724E-05 73 2.000E+00 1.200E+00 4.837E+01 4.031E-05 2.056E-04 6.8981E-05 7.1433E-05 1.4009E-05 74 3.000E+00 1.200E+00 7.228E+01 2.013E-05 3.071E-04 6.8974E-05 7.2637E-05 4.7621E-06 75 4.000E+00 1.200E+00 9.607E+01 8.049E-06 4.082E-04 6.8967E-05 7.3837E-05 1.4559E-06 76 5.000E+00 1.200E+00 1.198E+02 2.814E-06 5.090E-04 6.8960E-05 7.5032E-05 4.1483E-07 77 6.000E+00 1.200E+00 1.435E+02 9.021E-07 6.096E-04 6.8953E-05 7.6225E-05 1.1279E-07 78 7.000E+00 1.200E+00 1.671E+02 2.726E-07 7.101E-04 6.8946E-05 7.7416E-05 2.9725E-08 79 8.000E+00 1.200E+00 1.908E+02 7.910E-08 8.104E-04 6.8939E-05 7.8606E-05 7.6721E-09 80 9.000E+00 1.200E+00 2.144E+02 2.229E-08 9.107E-04 6.8932E-05 7.9796E-05 1.9528E-09 81 1.000E+01 1.200E+00 2.380E+02 6.147E-09 1.011E-03 6.8925E-05 8.0984E-05 4.9241E-10 82 1.250E+01 1.200E+00 2.970E+02 2.308E-10 1.261E-03 6.8908E-05 8.3954E-05 1.5360E-11 83 1.500E+01 1.200E+00 3.560E+02 8.200E-12 1.512E-03 6.8891E-05 8.6923E-05 4.7152E-13 84 1.750E+01 1.200E+00 4.149E+02 2.819E-13 1.762E-03 6.8874E-05 8.9891E-05 1.4380E-14 85 2.000E+01 1.200E+00 4.739E+02 9.474E-15 2.012E-03 6.8856E-05 9.2858E-05 4.3723E-16 86 2.500E+01 1.200E+00 5.919E+02 1.023E-17 2.512E-03 6.8822E-05 9.8789E-05 4.0231E-19 87 3.000E+01 1.200E+00 7.098E+02 1.060E-20 3.012E-03 6.8787E-05 1.0472E-04 3.6866E-22 88 3.500E+01 1.200E+00 8.278E+02 1.069E-23 3.512E-03 6.8753E-05 1.1064E-04 3.3672E-25 89 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 90 1.000E-01 1.200E+01 2.445E+00 9.832E-06 1.039E-05 6.8995E-05 6.9118E-05 6.5404E-05 91 2.500E-01 1.200E+01 6.105E+00 2.245E-05 2.595E-05 6.8993E-05 6.9303E-05 5.9961E-05 92 5.000E-01 1.200E+01 1.219E+01 3.794E-05 5.180E-05 6.8992E-05 6.9610E-05 5.0978E-05 93 1.000E+00 1.200E+01 2.429E+01 5.089E-05 1.032E-04 6.8988E-05 7.0220E-05 3.4614E-05 94 1.500E+00 1.200E+01 3.632E+01 4.736E-05 1.543E-04 6.8985E-05 7.0826E-05 2.1732E-05 95 2.000E+00 1.200E+01 4.827E+01 3.643E-05 2.051E-04 6.8981E-05 7.1428E-05 1.2686E-05 96 3.000E+00 1.200E+01 7.198E+01 1.493E-05 3.059E-04 6.8974E-05 7.2623E-05 3.5456E-06 97 4.000E+00 1.200E+01 9.545E+01 4.303E-06 4.056E-04 6.8967E-05 7.3805E-05 7.8297E-07 98 5.000E+00 1.200E+01 1.187E+02 9.469E-07 5.044E-04 6.8960E-05 7.4978E-05 1.4075E-07 99 6.000E+00 1.200E+01 1.418E+02 1.671E-07 6.025E-04 6.8954E-05 7.6141E-05 2.1122E-08 100 7.000E+00 1.200E+01 1.647E+02 2.448E-08 6.999E-04 6.8947E-05 7.7295E-05 2.7036E-09 101 8.000E+00 1.200E+01 1.875E+02 3.053E-09 7.967E-04 6.8940E-05 7.8443E-05 3.0065E-10 102 9.000E+00 1.200E+01 2.102E+02 3.311E-10 8.929E-04 6.8934E-05 7.9585E-05 2.9512E-11 103 1.000E+01 1.200E+01 2.327E+02 3.176E-11 9.887E-04 6.8927E-05 8.0720E-05 2.5927E-12 104 1.250E+01 1.200E+01 2.887E+02 5.776E-14 1.226E-03 6.8911E-05 8.3538E-05 3.9347E-15 105 1.500E+01 1.200E+01 3.442E+02 6.311E-17 1.462E-03 6.8894E-05 8.6332E-05 3.7267E-18 106 1.750E+01 1.200E+01 3.994E+02 4.683E-20 1.696E-03 6.8878E-05 8.9107E-05 2.4604E-21 107 2.000E+01 1.200E+01 4.542E+02 2.581E-23 1.929E-03 6.8862E-05 9.1868E-05 1.2294E-24 108 2.500E+01 1.200E+01 5.634E+02 4.131E-30 2.391E-03 6.8830E-05 9.7357E-05 1.6816E-31 109 3.000E+01 1.200E+01 6.720E+02 3.726E-37 2.852E-03 6.8798E-05 1.0282E-04 1.3432E-38 110 3.500E+01 1.200E+01 7.803E+02 2.351E-44 3.311E-03 6.8767E-05 1.0826E-04 7.6882E-46 111 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 112 1.000E-01 5.400E+01 2.445E+00 9.832E-06 1.039E-05 6.8995E-05 6.9118E-05 6.5404E-05 113 2.500E-01 5.400E+01 6.105E+00 2.245E-05 2.595E-05 6.8993E-05 6.9303E-05 5.9959E-05 114 5.000E-01 5.400E+01 1.219E+01 3.793E-05 5.180E-05 6.8992E-05 6.9610E-05 5.0969E-05 115 1.000E+00 5.400E+01 2.429E+01 5.082E-05 1.032E-04 6.8988E-05 7.0219E-05 3.4568E-05 116 1.500E+00 5.400E+01 3.631E+01 4.715E-05 1.543E-04 6.8985E-05 7.0825E-05 2.1639E-05 117 2.000E+00 5.400E+01 4.826E+01 3.607E-05 2.051E-04 6.8981E-05 7.1427E-05 1.2562E-05 118 3.000E+00 5.400E+01 7.195E+01 1.447E-05 3.057E-04 6.8974E-05 7.2621E-05 3.4370E-06 119 4.000E+00 5.400E+01 9.538E+01 4.012E-06 4.053E-04 6.8967E-05 7.3802E-05 7.3048E-07 120 5.000E+00 5.400E+01 1.186E+02 8.324E-07 5.039E-04 6.8960E-05 7.4971E-05 1.2385E-07 121 6.000E+00 5.400E+01 1.416E+02 1.354E-07 6.016E-04 6.8954E-05 7.6130E-05 1.7137E-08 122 7.000E+00 5.400E+01 1.644E+02 1.784E-08 6.986E-04 6.8947E-05 7.7280E-05 1.9736E-09 123 8.000E+00 5.400E+01 1.871E+02 1.950E-09 7.948E-04 6.8940E-05 7.8421E-05 1.9244E-10 124 9.000E+00 5.400E+01 2.096E+02 1.805E-10 8.904E-04 6.8934E-05 7.9554E-05 1.6124E-11 125 1.000E+01 5.400E+01 2.320E+02 1.437E-11 9.853E-04 6.8927E-05 8.0681E-05 1.1764E-12 126 1.250E+01 5.400E+01 2.873E+02 1.451E-14 1.220E-03 6.8911E-05 8.3469E-05 9.9248E-16 127 1.500E+01 5.400E+01 3.421E+02 7.384E-18 1.453E-03 6.8895E-05 8.6225E-05 4.3821E-19 128 1.750E+01 5.400E+01 3.963E+02 2.146E-21 1.683E-03 6.8879E-05 8.8953E-05 1.1342E-22 129 2.000E+01 5.400E+01 4.501E+02 3.919E-25 1.911E-03 6.8863E-05 9.1658E-05 1.8795E-26 130 2.500E+01 5.400E+01 5.565E+02 4.304E-33 2.362E-03 6.8832E-05 9.7012E-05 1.7672E-34 131 3.000E+01 5.400E+01 6.619E+02 1.513E-41 2.809E-03 6.8801E-05 1.0231E-04 5.5117E-43 132 3.500E+01 5.400E+01 7.664E+02 2.282E-50 3.252E-03 6.8771E-05 1.0756E-04 7.5480E-52 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency RMRM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.534 (1/Gy), alpha/beta = 2.931 (Gy) , lamda = 3.577E-01 (1/h). ====================================================================================================== --- Duration (h) --- Dose Dose Rate* ***** G FACTOR ***** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL GEFF SF1 SF2 ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 6.667E-01 7.267E+01 1.000E-01 1.500E-01 9.250E-01 9.213E-01 9.4638E-01 9.463897E-01 3 1.667E+00 7.367E+01 2.500E-01 1.500E-01 8.277E-01 8.198E-01 8.6677E-01 8.668473E-01 4 3.333E+00 7.533E+01 5.000E-01 1.500E-01 6.975E-01 6.856E-01 7.4164E-01 7.420428E-01 5 6.667E+00 7.867E+01 1.000E+00 1.500E-01 5.194E-01 5.050E-01 5.3319E-01 5.345900E-01 6 1.000E+01 7.000E+01 1.500E+00 1.500E-01 4.072E-01 3.933E-01 3.7973E-01 3.819029E-01 7 1.333E+01 7.333E+01 2.000E+00 1.500E-01 3.322E-01 3.195E-01 2.6967E-01 2.721707E-01 8 2.000E+01 8.000E+01 3.000E+00 1.500E-01 2.405E-01 2.303E-01 1.3572E-01 1.380187E-01 9 2.667E+01 8.667E+01 4.000E+00 1.500E-01 1.877E-01 1.793E-01 6.8280E-02 6.996722E-02 10 3.333E+01 9.333E+01 5.000E+00 1.500E-01 1.537E-01 1.466E-01 3.4349E-02 3.546824E-02 11 4.000E+01 1.000E+02 6.000E+00 1.500E-01 1.300E-01 1.239E-01 1.7279E-02 1.797976E-02 12 4.667E+01 1.067E+02 7.000E+00 1.500E-01 1.126E-01 1.073E-01 8.6924E-03 9.114398E-03 13 5.333E+01 1.133E+02 8.000E+00 1.500E-01 9.933E-02 9.461E-02 4.3727E-03 4.620320E-03 14 6.000E+01 1.200E+02 9.000E+00 1.500E-01 8.884E-02 8.459E-02 2.1997E-03 2.342158E-03 15 6.667E+01 1.267E+02 1.000E+01 1.500E-01 8.035E-02 7.648E-02 1.1066E-03 1.187299E-03 16 8.333E+01 1.433E+02 1.250E+01 1.500E-01 6.484E-02 6.169E-02 1.9862E-04 2.172303E-04 17 1.000E+02 1.600E+02 1.500E+01 1.500E-01 5.435E-02 5.169E-02 3.5650E-05 3.974484E-05 18 1.167E+02 1.767E+02 1.750E+01 1.500E-01 4.677E-02 4.448E-02 6.3988E-06 7.271784E-06 19 1.333E+02 1.933E+02 2.000E+01 1.500E-01 4.105E-02 3.904E-02 1.1485E-06 1.330458E-06 20 1.667E+02 2.267E+02 2.500E+01 1.500E-01 3.298E-02 3.136E-02 3.7001E-08 4.453707E-08 21 2.000E+02 2.600E+02 3.000E+01 1.500E-01 2.756E-02 2.620E-02 1.1920E-09 1.490878E-09 22 2.333E+02 2.933E+02 3.500E+01 1.500E-01 2.367E-02 2.250E-02 3.8403E-11 4.990713E-11 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 3.333E-01 7.233E+01 1.000E-01 3.000E-01 9.614E-01 9.574E-01 9.4632E-01 9.463274E-01 25 8.333E-01 7.283E+01 2.500E-01 3.000E-01 9.076E-01 8.985E-01 8.6598E-01 8.660702E-01 26 1.667E+00 7.367E+01 5.000E-01 3.000E-01 8.277E-01 8.121E-01 7.3726E-01 7.377800E-01 27 3.333E+00 7.533E+01 1.000E+00 3.000E-01 6.975E-01 6.742E-01 5.1616E-01 5.183580E-01 28 5.000E+00 7.700E+01 1.500E+00 3.000E-01 5.975E-01 5.708E-01 3.5122E-01 3.550939E-01 29 6.667E+00 7.867E+01 2.000E+00 3.000E-01 5.194E-01 4.915E-01 2.3526E-01 2.400838E-01 30 1.000E+01 7.000E+01 3.000E+00 3.000E-01 4.072E-01 3.804E-01 1.0326E-01 1.078874E-01 31 1.333E+01 7.333E+01 4.000E+00 3.000E-01 3.322E-01 3.079E-01 4.4807E-02 4.808962E-02 32 1.667E+01 7.667E+01 5.000E+00 3.000E-01 2.793E-01 2.576E-01 1.9375E-02 2.138869E-02 33 2.000E+01 8.000E+01 6.000E+00 3.000E-01 2.405E-01 2.211E-01 8.3690E-03 9.507408E-03 34 2.333E+01 8.333E+01 7.000E+00 3.000E-01 2.109E-01 1.934E-01 3.6139E-03 4.225437E-03 35 2.667E+01 8.667E+01 8.000E+00 3.000E-01 1.877E-01 1.718E-01 1.5604E-03 1.877858E-03 36 3.000E+01 9.000E+01 9.000E+00 3.000E-01 1.690E-01 1.545E-01 6.7371E-04 8.345435E-04 37 3.333E+01 9.333E+01 1.000E+01 3.000E-01 1.537E-01 1.403E-01 2.9088E-04 3.708803E-04 38 4.167E+01 1.017E+02 1.250E+01 3.000E-01 1.252E-01 1.141E-01 3.5630E-05 4.883091E-05 39 5.000E+01 1.100E+02 1.500E+01 3.000E-01 1.056E-01 9.612E-02 4.3642E-06 6.429182E-06 40 5.833E+01 1.183E+02 1.750E+01 3.000E-01 9.125E-02 8.302E-02 5.3457E-07 8.464798E-07 41 6.667E+01 1.267E+02 2.000E+01 3.000E-01 8.035E-02 7.305E-02 6.5479E-08 1.114493E-07 42 8.333E+01 1.433E+02 2.500E+01 3.000E-01 6.484E-02 5.890E-02 9.8241E-10 1.931965E-09 43 1.000E+02 1.600E+02 3.000E+01 3.000E-01 5.435E-02 4.934E-02 1.4740E-11 3.349045E-11 44 1.167E+02 1.767E+02 3.500E+01 3.000E-01 4.677E-02 4.245E-02 2.2114E-13 5.805542E-13 45 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 46 1.667E-01 7.217E+01 1.000E-01 6.000E-01 9.804E-01 9.763E-01 9.4629E-01 9.462948E-01 47 4.167E-01 7.242E+01 2.500E-01 6.000E-01 9.521E-01 9.424E-01 8.6554E-01 8.656381E-01 48 8.333E-01 7.283E+01 5.000E-01 6.000E-01 9.076E-01 8.897E-01 7.3458E-01 7.351770E-01 49 1.667E+00 7.367E+01 1.000E+00 6.000E-01 8.277E-01 7.972E-01 5.0406E-01 5.068713E-01 50 2.500E+00 7.450E+01 1.500E+00 6.000E-01 7.582E-01 7.190E-01 3.2883E-01 3.341496E-01 51 3.333E+00 7.533E+01 2.000E+00 6.000E-01 6.975E-01 6.526E-01 2.0661E-01 2.134946E-01 52 5.000E+00 7.700E+01 3.000E+00 6.000E-01 5.975E-01 5.466E-01 7.5566E-02 8.215154E-02 53 6.667E+00 6.667E+01 4.000E+00 6.000E-01 5.194E-01 4.670E-01 2.5957E-02 3.024343E-02 54 8.333E+00 6.833E+01 5.000E+00 6.000E-01 4.573E-01 4.057E-01 8.6130E-03 1.089515E-02 55 1.000E+01 7.000E+01 6.000E+00 6.000E-01 4.072E-01 3.575E-01 2.8041E-03 3.883480E-03 56 1.167E+01 7.167E+01 7.000E+00 6.000E-01 3.662E-01 3.190E-01 9.0337E-04 1.377039E-03 57 1.333E+01 7.333E+01 8.000E+00 6.000E-01 3.322E-01 2.875E-01 2.8935E-04 4.870372E-04 58 1.500E+01 7.500E+01 9.000E+00 6.000E-01 3.036E-01 2.615E-01 9.2387E-05 1.720417E-04 59 1.667E+01 7.667E+01 1.000E+01 6.000E-01 2.793E-01 2.396E-01 2.9446E-05 6.073492E-05 60 2.083E+01 8.083E+01 1.250E+01 6.000E-01 2.324E-01 1.979E-01 1.6832E-06 4.492765E-06 61 2.500E+01 8.500E+01 1.500E+01 6.000E-01 1.986E-01 1.684E-01 9.6060E-08 3.322140E-07 62 2.917E+01 8.917E+01 1.750E+01 6.000E-01 1.733E-01 1.464E-01 5.4803E-09 2.456368E-08 63 3.333E+01 9.333E+01 2.000E+01 6.000E-01 1.537E-01 1.295E-01 3.1262E-10 1.816202E-09 64 4.167E+01 1.017E+02 2.500E+01 6.000E-01 1.252E-01 1.052E-01 1.0173E-12 9.928955E-12 65 5.000E+01 1.100E+02 3.000E+01 6.000E-01 1.056E-01 8.851E-02 3.3104E-15 5.428038E-14 66 5.833E+01 1.183E+02 3.500E+01 6.000E-01 9.125E-02 7.640E-02 1.0772E-17 2.967441E-16 67 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 68 8.333E-02 7.208E+01 1.000E-01 1.200E+00 9.901E-01 9.860E-01 9.4627E-01 9.462781E-01 69 2.083E-01 7.221E+01 2.500E-01 1.200E+00 9.756E-01 9.655E-01 8.6531E-01 8.654100E-01 70 4.167E-01 7.242E+01 5.000E-01 1.200E+00 9.521E-01 9.328E-01 7.3309E-01 7.337331E-01 71 8.333E-01 7.283E+01 1.000E+00 1.200E+00 9.076E-01 8.725E-01 4.9677E-01 4.999592E-01 72 1.250E+00 7.325E+01 1.500E+00 1.200E+00 8.662E-01 8.182E-01 3.1458E-01 3.208376E-01 73 1.667E+00 7.367E+01 2.000E+00 1.200E+00 8.277E-01 7.691E-01 1.8791E-01 1.961108E-01 74 2.500E+00 7.450E+01 3.000E+00 1.200E+00 7.582E-01 6.841E-01 5.8061E-02 6.556001E-02 75 3.333E+00 7.533E+01 4.000E+00 1.200E+00 6.975E-01 6.137E-01 1.5439E-02 1.971771E-02 76 4.167E+00 7.617E+01 5.000E+00 1.200E+00 6.444E-01 5.546E-01 3.6724E-03 5.528768E-03 77 5.000E+00 7.700E+01 6.000E+00 1.200E+00 5.975E-01 5.046E-01 8.0419E-04 1.479725E-03 78 5.833E+00 6.583E+01 7.000E+00 1.200E+00 5.561E-01 4.620E-01 1.6562E-04 3.839652E-04 79 6.667E+00 6.667E+01 8.000E+00 1.200E+00 5.194E-01 4.253E-01 3.2589E-05 9.760220E-05 80 7.500E+00 6.750E+01 9.000E+00 1.200E+00 4.866E-01 3.936E-01 6.1992E-06 2.447229E-05 81 8.333E+00 6.833E+01 1.000E+01 1.200E+00 4.573E-01 3.659E-01 1.1500E-06 6.080319E-06 82 1.042E+01 7.042E+01 1.250E+01 1.200E+00 3.962E-01 3.103E-01 1.5872E-08 1.829583E-07 83 1.250E+01 7.250E+01 1.500E+01 1.200E+00 3.484E-01 2.687E-01 2.0683E-10 5.424517E-09 84 1.458E+01 7.458E+01 1.750E+01 1.200E+00 3.103E-01 2.366E-01 2.6228E-12 1.599726E-10 85 1.667E+01 7.667E+01 2.000E+01 1.200E+00 2.793E-01 2.112E-01 3.2831E-14 4.708557E-12 86 2.083E+01 8.083E+01 2.500E+01 1.200E+00 2.324E-01 1.736E-01 5.0667E-18 4.072411E-15 87 2.500E+01 8.500E+01 3.000E+01 1.200E+00 1.986E-01 1.473E-01 7.7699E-22 3.520548E-18 88 2.917E+01 8.917E+01 3.500E+01 1.200E+00 1.733E-01 1.279E-01 1.1898E-25 3.043280E-21 89 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 90 8.333E-03 7.201E+01 1.000E-01 1.200E+01 9.990E-01 9.948E-01 9.4626E-01 9.462629E-01 91 2.083E-02 7.202E+01 2.500E-01 1.200E+01 9.975E-01 9.871E-01 8.6509E-01 8.651974E-01 92 4.167E-02 7.204E+01 5.000E-01 1.200E+01 9.951E-01 9.744E-01 7.3166E-01 7.323430E-01 93 8.333E-02 7.208E+01 1.000E+00 1.200E+01 9.901E-01 9.501E-01 4.8936E-01 4.929344E-01 94 1.250E-01 7.212E+01 1.500E+00 1.200E+01 9.853E-01 9.270E-01 2.9959E-01 3.068312E-01 95 1.667E-01 7.217E+01 2.000E+00 1.200E+01 9.804E-01 9.050E-01 1.6811E-01 1.776115E-01 96 2.500E-01 7.225E+01 3.000E+00 1.200E+01 9.708E-01 8.639E-01 4.0965E-02 4.882261E-02 97 3.333E-01 7.233E+01 4.000E+00 1.200E+01 9.614E-01 8.262E-01 7.1526E-03 1.060865E-02 98 4.167E-01 7.242E+01 5.000E+00 1.200E+01 9.521E-01 7.916E-01 9.0365E-04 1.877225E-03 99 5.000E-01 7.250E+01 6.000E+00 1.200E+01 9.430E-01 7.598E-01 8.3398E-05 2.774097E-04 100 5.833E-01 7.258E+01 7.000E+00 1.200E+01 9.339E-01 7.303E-01 5.6745E-06 3.497759E-05 101 6.667E-01 7.267E+01 8.000E+00 1.200E+01 9.250E-01 7.029E-01 2.8721E-07 3.832741E-06 102 7.500E-01 7.275E+01 9.000E+00 1.200E+01 9.163E-01 6.774E-01 1.0909E-08 3.708289E-07 103 8.333E-01 7.283E+01 1.000E+01 1.200E+01 9.076E-01 6.536E-01 3.1352E-10 3.211898E-08 104 1.042E+00 7.304E+01 1.250E+01 1.200E+01 8.865E-01 6.005E-01 1.3677E-14 4.710095E-11 105 1.250E+00 7.325E+01 1.500E+01 1.200E+01 8.662E-01 5.551E-01 1.2411E-19 4.316740E-14 106 1.458E+00 7.346E+01 1.750E+01 1.200E+01 8.466E-01 5.156E-01 2.6223E-25 2.761130E-17 107 1.667E+00 7.367E+01 2.000E+01 1.200E+01 8.277E-01 4.812E-01 1.4325E-31 1.338215E-20 108 2.083E+00 6.208E+01 2.500E+01 1.200E+01 7.917E-01 4.238E-01 1.0819E-45 1.727272E-27 109 2.500E+00 6.250E+01 3.000E+01 1.200E+01 7.582E-01 3.780E-01 1.0730E-61 1.306378E-34 110 2.917E+00 6.292E+01 3.500E+01 1.200E+01 7.269E-01 3.407E-01 2.5460E-79 7.101845E-42 111 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 112 1.852E-03 7.200E+01 1.000E-01 5.400E+01 9.998E-01 9.955E-01 9.4625E-01 9.462616E-01 113 4.630E-03 7.200E+01 2.500E-01 5.400E+01 9.994E-01 9.890E-01 8.6508E-01 8.651787E-01 114 9.259E-03 7.201E+01 5.000E-01 5.400E+01 9.989E-01 9.782E-01 7.3153E-01 7.322187E-01 115 1.852E-02 7.202E+01 1.000E+00 5.400E+01 9.978E-01 9.573E-01 4.8867E-01 4.922880E-01 116 2.778E-02 7.203E+01 1.500E+00 5.400E+01 9.967E-01 9.375E-01 2.9819E-01 3.055205E-01 117 3.704E-02 7.204E+01 2.000E+00 5.400E+01 9.956E-01 9.185E-01 1.6626E-01 1.758764E-01 118 5.556E-02 7.206E+01 3.000E+00 5.400E+01 9.934E-01 8.828E-01 3.9476E-02 4.732806E-02 119 7.407E-02 7.207E+01 4.000E+00 5.400E+01 9.912E-01 8.500E-01 6.5570E-03 9.897808E-03 120 9.259E-02 7.209E+01 5.000E+00 5.400E+01 9.890E-01 8.197E-01 7.6369E-04 1.651971E-03 121 1.111E-01 7.211E+01 6.000E+00 5.400E+01 9.869E-01 7.916E-01 6.2515E-05 2.251045E-04 122 1.296E-01 7.213E+01 7.000E+00 5.400E+01 9.847E-01 7.655E-01 3.6052E-06 2.553896E-05 123 1.481E-01 7.215E+01 8.000E+00 5.400E+01 9.826E-01 7.411E-01 1.4681E-07 2.453912E-06 124 1.667E-01 7.217E+01 9.000E+00 5.400E+01 9.804E-01 7.183E-01 4.2310E-09 2.026839E-07 125 1.852E-01 7.219E+01 1.000E+01 5.400E+01 9.783E-01 6.969E-01 8.6496E-11 1.458037E-08 126 2.315E-01 7.223E+01 1.250E+01 5.400E+01 9.730E-01 6.489E-01 1.1678E-15 1.189037E-11 127 2.778E-01 7.228E+01 1.500E+01 5.400E+01 9.677E-01 6.072E-01 1.9363E-21 5.082231E-15 128 3.241E-01 7.232E+01 1.750E+01 5.400E+01 9.625E-01 5.707E-01 4.0813E-28 1.275058E-18 129 3.704E-01 7.237E+01 2.000E+01 5.400E+01 9.573E-01 5.385E-01 1.1312E-35 2.050571E-22 130 4.630E-01 7.246E+01 2.500E+01 5.400E+01 9.470E-01 4.839E-01 2.2566E-53 1.821683E-30 131 5.556E-01 6.056E+01 3.000E+01 5.400E+01 9.369E-01 4.395E-01 1.9935E-74 5.387341E-39 132 6.481E-01 6.065E+01 3.500E+01 5.400E+01 9.270E-01 4.026E-01 1.0031E-98 7.017405E-48 ------------------------------------------------------------------------------------------------------ GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/D)/(beta*D). In the formula for GEFF, SF is surviving fraction as computed using the RMR model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL. The SF estimates are: SF1=EXP{-dose*[alpha+gl*beta*dose]} and SF2=EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 3.028E+00 1.000E-01 9.4639E-01 9.4639E-01 9.4639E-01 3.8814E-01 3.8814E-01 3.8814E-01 3.8814E-01 3 3.069E+00 2.500E-01 8.6685E-01 8.6685E-01 8.6685E-01 4.2027E-01 4.2027E-01 4.2027E-01 4.2027E-01 4 3.139E+00 5.000E-01 7.4204E-01 7.4204E-01 7.4204E-01 4.7614E-01 4.7614E-01 4.7614E-01 4.7614E-01 5 3.278E+00 1.000E+00 5.3459E-01 5.3459E-01 5.3459E-01 5.8591E-01 5.8591E-01 5.8591E-01 5.8591E-01 6 2.917E+00 1.500E+00 3.8190E-01 3.8190E-01 3.8190E-01 6.8256E-01 6.8256E-01 6.8256E-01 6.8256E-01 7 3.056E+00 2.000E+00 2.7217E-01 2.7217E-01 2.7217E-01 7.6172E-01 7.6172E-01 7.6172E-01 7.6172E-01 8 3.333E+00 3.000E+00 1.3802E-01 1.3802E-01 1.3802E-01 8.7108E-01 8.7108E-01 8.7108E-01 8.7108E-01 9 3.611E+00 4.000E+00 6.9967E-02 6.9967E-02 6.9967E-02 9.3242E-01 9.3242E-01 9.3242E-01 9.3242E-01 10 3.889E+00 5.000E+00 3.5468E-02 3.5468E-02 3.5468E-02 9.6515E-01 9.6515E-01 9.6515E-01 9.6515E-01 11 4.167E+00 6.000E+00 1.7980E-02 1.7980E-02 1.7980E-02 9.8218E-01 9.8218E-01 9.8218E-01 9.8218E-01 12 4.444E+00 7.000E+00 9.1144E-03 9.1144E-03 9.1144E-03 9.9093E-01 9.9093E-01 9.9093E-01 9.9093E-01 13 4.722E+00 8.000E+00 4.6203E-03 4.6203E-03 4.6203E-03 9.9539E-01 9.9539E-01 9.9539E-01 9.9539E-01 14 5.000E+00 9.000E+00 2.3422E-03 2.3422E-03 2.3422E-03 9.9766E-01 9.9766E-01 9.9766E-01 9.9766E-01 15 5.278E+00 1.000E+01 1.1873E-03 1.1873E-03 1.1873E-03 9.9881E-01 9.9881E-01 9.9881E-01 9.9881E-01 16 5.972E+00 1.250E+01 2.1723E-04 2.1723E-04 2.1723E-04 9.9978E-01 9.9978E-01 9.9978E-01 9.9978E-01 17 6.667E+00 1.500E+01 3.9745E-05 3.9745E-05 3.9745E-05 9.9996E-01 9.9996E-01 9.9996E-01 9.9996E-01 18 7.361E+00 1.750E+01 7.2718E-06 7.2718E-06 7.2718E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 19 8.056E+00 2.000E+01 1.3305E-06 1.3305E-06 1.3305E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 20 9.444E+00 2.500E+01 4.4537E-08 4.4537E-08 4.4537E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 1.083E+01 3.000E+01 1.4909E-09 1.4909E-09 1.4909E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 1.222E+01 3.500E+01 4.9907E-11 4.9907E-11 4.9907E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 3.014E+00 1.000E-01 9.4633E-01 9.4633E-01 9.4633E-01 3.8816E-01 3.8816E-01 3.8816E-01 3.8816E-01 25 3.035E+00 2.500E-01 8.6607E-01 8.6607E-01 8.6607E-01 4.2060E-01 4.2060E-01 4.2060E-01 4.2060E-01 26 3.069E+00 5.000E-01 7.3778E-01 7.3778E-01 7.3778E-01 4.7817E-01 4.7817E-01 4.7817E-01 4.7817E-01 27 3.139E+00 1.000E+00 5.1836E-01 5.1836E-01 5.1836E-01 5.9550E-01 5.9550E-01 5.9550E-01 5.9550E-01 28 3.208E+00 1.500E+00 3.5509E-01 3.5509E-01 3.5509E-01 7.0111E-01 7.0111E-01 7.0111E-01 7.0111E-01 29 3.278E+00 2.000E+00 2.4008E-01 2.4008E-01 2.4008E-01 7.8656E-01 7.8656E-01 7.8656E-01 7.8656E-01 30 2.917E+00 3.000E+00 1.0789E-01 1.0789E-01 1.0789E-01 8.9773E-01 8.9773E-01 8.9773E-01 8.9773E-01 31 3.056E+00 4.000E+00 4.8090E-02 4.8090E-02 4.8090E-02 9.5305E-01 9.5305E-01 9.5305E-01 9.5305E-01 32 3.194E+00 5.000E+00 2.1389E-02 2.1389E-02 2.1389E-02 9.7884E-01 9.7884E-01 9.7884E-01 9.7884E-01 33 3.333E+00 6.000E+00 9.5074E-03 9.5074E-03 9.5074E-03 9.9054E-01 9.9054E-01 9.9054E-01 9.9054E-01 34 3.472E+00 7.000E+00 4.2254E-03 4.2254E-03 4.2254E-03 9.9578E-01 9.9578E-01 9.9578E-01 9.9578E-01 35 3.611E+00 8.000E+00 1.8779E-03 1.8779E-03 1.8779E-03 9.9812E-01 9.9812E-01 9.9812E-01 9.9812E-01 36 3.750E+00 9.000E+00 8.3454E-04 8.3454E-04 8.3454E-04 9.9917E-01 9.9917E-01 9.9917E-01 9.9917E-01 37 3.889E+00 1.000E+01 3.7088E-04 3.7088E-04 3.7088E-04 9.9963E-01 9.9963E-01 9.9963E-01 9.9963E-01 38 4.236E+00 1.250E+01 4.8831E-05 4.8831E-05 4.8831E-05 9.9995E-01 9.9995E-01 9.9995E-01 9.9995E-01 39 4.583E+00 1.500E+01 6.4292E-06 6.4292E-06 6.4292E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 40 4.931E+00 1.750E+01 8.4648E-07 8.4648E-07 8.4648E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 5.278E+00 2.000E+01 1.1145E-07 1.1145E-07 1.1145E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 5.972E+00 2.500E+01 1.9320E-09 1.9320E-09 1.9320E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 6.667E+00 3.000E+01 3.3490E-11 3.3490E-11 3.3490E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 7.361E+00 3.500E+01 5.8055E-13 5.8055E-13 5.8055E-13 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 45 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 46 3.007E+00 1.000E-01 9.4629E-01 9.4629E-01 9.4629E-01 3.8818E-01 3.8818E-01 3.8818E-01 3.8818E-01 47 3.017E+00 2.500E-01 8.6564E-01 8.6564E-01 8.6564E-01 4.2078E-01 4.2078E-01 4.2078E-01 4.2078E-01 48 3.035E+00 5.000E-01 7.3518E-01 7.3518E-01 7.3518E-01 4.7942E-01 4.7942E-01 4.7942E-01 4.7942E-01 49 3.069E+00 1.000E+00 5.0687E-01 5.0687E-01 5.0687E-01 6.0238E-01 6.0238E-01 6.0238E-01 6.0238E-01 50 3.104E+00 1.500E+00 3.3415E-01 3.3415E-01 3.3415E-01 7.1595E-01 7.1595E-01 7.1595E-01 7.1595E-01 51 3.139E+00 2.000E+00 2.1349E-01 2.1349E-01 2.1349E-01 8.0776E-01 8.0776E-01 8.0776E-01 8.0776E-01 52 3.208E+00 3.000E+00 8.2152E-02 8.2152E-02 8.2152E-02 9.2113E-01 9.2113E-01 9.2113E-01 9.2113E-01 53 2.778E+00 4.000E+00 3.0243E-02 3.0243E-02 3.0243E-02 9.7021E-01 9.7021E-01 9.7021E-01 9.7021E-01 54 2.847E+00 5.000E+00 1.0895E-02 1.0895E-02 1.0895E-02 9.8916E-01 9.8916E-01 9.8916E-01 9.8916E-01 55 2.917E+00 6.000E+00 3.8835E-03 3.8835E-03 3.8835E-03 9.9612E-01 9.9612E-01 9.9612E-01 9.9612E-01 56 2.986E+00 7.000E+00 1.3770E-03 1.3770E-03 1.3770E-03 9.9862E-01 9.9862E-01 9.9862E-01 9.9862E-01 57 3.056E+00 8.000E+00 4.8704E-04 4.8704E-04 4.8704E-04 9.9951E-01 9.9951E-01 9.9951E-01 9.9951E-01 58 3.125E+00 9.000E+00 1.7204E-04 1.7204E-04 1.7204E-04 9.9983E-01 9.9983E-01 9.9983E-01 9.9983E-01 59 3.194E+00 1.000E+01 6.0735E-05 6.0735E-05 6.0735E-05 9.9994E-01 9.9994E-01 9.9994E-01 9.9994E-01 60 3.368E+00 1.250E+01 4.4928E-06 4.4928E-06 4.4928E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 61 3.542E+00 1.500E+01 3.3221E-07 3.3221E-07 3.3221E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 62 3.715E+00 1.750E+01 2.4564E-08 2.4564E-08 2.4564E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 63 3.889E+00 2.000E+01 1.8162E-09 1.8162E-09 1.8162E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 64 4.236E+00 2.500E+01 9.9290E-12 9.9290E-12 9.9290E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 65 4.583E+00 3.000E+01 5.4280E-14 5.4280E-14 5.4280E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 66 4.931E+00 3.500E+01 2.9674E-16 2.9674E-16 2.9674E-16 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 67 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 68 3.003E+00 1.000E-01 9.4628E-01 9.4628E-01 9.4628E-01 3.8818E-01 3.8818E-01 3.8818E-01 3.8818E-01 69 3.009E+00 2.500E-01 8.6541E-01 8.6541E-01 8.6541E-01 4.2088E-01 4.2088E-01 4.2088E-01 4.2088E-01 70 3.017E+00 5.000E-01 7.3373E-01 7.3373E-01 7.3373E-01 4.8011E-01 4.8011E-01 4.8011E-01 4.8011E-01 71 3.035E+00 1.000E+00 4.9996E-01 4.9996E-01 4.9996E-01 6.0656E-01 6.0656E-01 6.0656E-01 6.0656E-01 72 3.052E+00 1.500E+00 3.2084E-01 3.2084E-01 3.2084E-01 7.2554E-01 7.2554E-01 7.2554E-01 7.2554E-01 73 3.069E+00 2.000E+00 1.9611E-01 1.9611E-01 1.9611E-01 8.2192E-01 8.2192E-01 8.2192E-01 8.2192E-01 74 3.104E+00 3.000E+00 6.5560E-02 6.5560E-02 6.5560E-02 9.3654E-01 9.3654E-01 9.3654E-01 9.3654E-01 75 3.139E+00 4.000E+00 1.9718E-02 1.9718E-02 1.9718E-02 9.8048E-01 9.8048E-01 9.8048E-01 9.8048E-01 76 3.174E+00 5.000E+00 5.5288E-03 5.5288E-03 5.5288E-03 9.9449E-01 9.9449E-01 9.9449E-01 9.9449E-01 77 3.208E+00 6.000E+00 1.4797E-03 1.4797E-03 1.4797E-03 9.9852E-01 9.9852E-01 9.9852E-01 9.9852E-01 78 2.743E+00 7.000E+00 3.8397E-04 3.8397E-04 3.8397E-04 9.9962E-01 9.9962E-01 9.9962E-01 9.9962E-01 79 2.778E+00 8.000E+00 9.7602E-05 9.7602E-05 9.7602E-05 9.9990E-01 9.9990E-01 9.9990E-01 9.9990E-01 80 2.812E+00 9.000E+00 2.4472E-05 2.4472E-05 2.4472E-05 9.9998E-01 9.9998E-01 9.9998E-01 9.9998E-01 81 2.847E+00 1.000E+01 6.0803E-06 6.0803E-06 6.0803E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 82 2.934E+00 1.250E+01 1.8296E-07 1.8296E-07 1.8296E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 83 3.021E+00 1.500E+01 5.4245E-09 5.4245E-09 5.4245E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 84 3.108E+00 1.750E+01 1.5997E-10 1.5997E-10 1.5997E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 85 3.194E+00 2.000E+01 4.7086E-12 4.7086E-12 4.7086E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 86 3.368E+00 2.500E+01 4.0724E-15 4.0724E-15 4.0724E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 87 3.542E+00 3.000E+01 3.5205E-18 3.5205E-18 3.5205E-18 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 88 3.715E+00 3.500E+01 3.0433E-21 3.0433E-21 3.0433E-21 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 89 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 90 3.000E+00 1.000E-01 9.4626E-01 9.4626E-01 9.4626E-01 3.8819E-01 3.8819E-01 3.8819E-01 3.8819E-01 91 3.001E+00 2.500E-01 8.6520E-01 8.6520E-01 8.6520E-01 4.2097E-01 4.2097E-01 4.2097E-01 4.2097E-01 92 3.002E+00 5.000E-01 7.3234E-01 7.3234E-01 7.3234E-01 4.8078E-01 4.8078E-01 4.8078E-01 4.8078E-01 93 3.003E+00 1.000E+00 4.9293E-01 4.9293E-01 4.9293E-01 6.1083E-01 6.1083E-01 6.1083E-01 6.1083E-01 94 3.005E+00 1.500E+00 3.0683E-01 3.0683E-01 3.0683E-01 7.3577E-01 7.3577E-01 7.3577E-01 7.3577E-01 95 3.007E+00 2.000E+00 1.7761E-01 1.7761E-01 1.7761E-01 8.3727E-01 8.3727E-01 8.3727E-01 8.3727E-01 96 3.010E+00 3.000E+00 4.8823E-02 4.8823E-02 4.8823E-02 9.5235E-01 9.5235E-01 9.5235E-01 9.5235E-01 97 3.014E+00 4.000E+00 1.0609E-02 1.0609E-02 1.0609E-02 9.8945E-01 9.8945E-01 9.8945E-01 9.8945E-01 98 3.017E+00 5.000E+00 1.8772E-03 1.8772E-03 1.8772E-03 9.9812E-01 9.9812E-01 9.9812E-01 9.9812E-01 99 3.021E+00 6.000E+00 2.7741E-04 2.7741E-04 2.7741E-04 9.9972E-01 9.9972E-01 9.9972E-01 9.9972E-01 100 3.024E+00 7.000E+00 3.4978E-05 3.4978E-05 3.4978E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 101 3.028E+00 8.000E+00 3.8327E-06 3.8327E-06 3.8327E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 102 3.031E+00 9.000E+00 3.7083E-07 3.7083E-07 3.7083E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 103 3.035E+00 1.000E+01 3.2119E-08 3.2119E-08 3.2119E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 104 3.043E+00 1.250E+01 4.7101E-11 4.7101E-11 4.7101E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 105 3.052E+00 1.500E+01 4.3167E-14 4.3167E-14 4.3167E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 106 3.061E+00 1.750E+01 2.7611E-17 2.7611E-17 2.7611E-17 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 107 3.069E+00 2.000E+01 1.3382E-20 1.3382E-20 1.3382E-20 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 108 2.587E+00 2.500E+01 1.7273E-27 1.7273E-27 1.7273E-27 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 109 2.604E+00 3.000E+01 1.3064E-34 1.3064E-34 1.3064E-34 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 110 2.622E+00 3.500E+01 7.1018E-42 7.1018E-42 7.1018E-42 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 111 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 112 3.000E+00 1.000E-01 9.4626E-01 9.4626E-01 9.4626E-01 3.8819E-01 3.8819E-01 3.8819E-01 3.8819E-01 113 3.000E+00 2.500E-01 8.6518E-01 8.6518E-01 8.6518E-01 4.2098E-01 4.2098E-01 4.2098E-01 4.2098E-01 114 3.000E+00 5.000E-01 7.3222E-01 7.3222E-01 7.3222E-01 4.8084E-01 4.8084E-01 4.8084E-01 4.8084E-01 115 3.001E+00 1.000E+00 4.9229E-01 4.9229E-01 4.9229E-01 6.1123E-01 6.1123E-01 6.1123E-01 6.1123E-01 116 3.001E+00 1.500E+00 3.0552E-01 3.0552E-01 3.0552E-01 7.3674E-01 7.3674E-01 7.3674E-01 7.3674E-01 117 3.002E+00 2.000E+00 1.7588E-01 1.7588E-01 1.7588E-01 8.3872E-01 8.3872E-01 8.3872E-01 8.3872E-01 118 3.002E+00 3.000E+00 4.7328E-02 4.7328E-02 4.7328E-02 9.5377E-01 9.5377E-01 9.5377E-01 9.5377E-01 119 3.003E+00 4.000E+00 9.8978E-03 9.8978E-03 9.8978E-03 9.9015E-01 9.9015E-01 9.9015E-01 9.9015E-01 120 3.004E+00 5.000E+00 1.6520E-03 1.6520E-03 1.6520E-03 9.9835E-01 9.9835E-01 9.9835E-01 9.9835E-01 121 3.005E+00 6.000E+00 2.2510E-04 2.2510E-04 2.2510E-04 9.9977E-01 9.9977E-01 9.9977E-01 9.9977E-01 122 3.005E+00 7.000E+00 2.5539E-05 2.5539E-05 2.5539E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 123 3.006E+00 8.000E+00 2.4539E-06 2.4539E-06 2.4539E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 124 3.007E+00 9.000E+00 2.0268E-07 2.0268E-07 2.0268E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 125 3.008E+00 1.000E+01 1.4580E-08 1.4580E-08 1.4580E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 126 3.010E+00 1.250E+01 1.1890E-11 1.1890E-11 1.1890E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 127 3.012E+00 1.500E+01 5.0822E-15 5.0822E-15 5.0822E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 128 3.014E+00 1.750E+01 1.2751E-18 1.2751E-18 1.2751E-18 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 129 3.015E+00 2.000E+01 2.0506E-22 2.0506E-22 2.0506E-22 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 130 3.019E+00 2.500E+01 1.8217E-30 1.8217E-30 1.8217E-30 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 131 2.523E+00 3.000E+01 5.3873E-39 5.3873E-39 5.3873E-39 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 132 2.527E+00 3.500E+01 7.0174E-48 7.0174E-48 7.0174E-48 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 6.667E-01 2.778E-02 0.0000E+00 1.0000E-01 0.0000E+00 1.5000E-01 3 1.667E+00 6.944E-02 0.0000E+00 2.5000E-01 0.0000E+00 1.5000E-01 4 3.333E+00 1.389E-01 0.0000E+00 5.0000E-01 0.0000E+00 1.5000E-01 5 6.667E+00 2.778E-01 0.0000E+00 1.0000E+00 0.0000E+00 1.5000E-01 6 1.000E+01 4.167E-01 0.0000E+00 1.5000E+00 0.0000E+00 1.5000E-01 7 1.333E+01 5.556E-01 0.0000E+00 2.0000E+00 0.0000E+00 1.5000E-01 8 2.000E+01 8.333E-01 0.0000E+00 3.0000E+00 0.0000E+00 1.5000E-01 9 2.667E+01 1.111E+00 0.0000E+00 4.0000E+00 0.0000E+00 1.5000E-01 10 3.333E+01 1.389E+00 0.0000E+00 5.0000E+00 0.0000E+00 1.5000E-01 11 4.000E+01 1.667E+00 0.0000E+00 6.0000E+00 0.0000E+00 1.5000E-01 12 4.667E+01 1.944E+00 0.0000E+00 7.0000E+00 0.0000E+00 1.5000E-01 13 5.333E+01 2.222E+00 0.0000E+00 8.0000E+00 0.0000E+00 1.5000E-01 14 6.000E+01 2.500E+00 0.0000E+00 9.0000E+00 0.0000E+00 1.5000E-01 15 6.667E+01 2.778E+00 0.0000E+00 1.0000E+01 0.0000E+00 1.5000E-01 16 8.333E+01 3.472E+00 0.0000E+00 1.2500E+01 0.0000E+00 1.5000E-01 17 1.000E+02 4.167E+00 0.0000E+00 1.5000E+01 0.0000E+00 1.5000E-01 18 1.167E+02 4.861E+00 0.0000E+00 1.7500E+01 0.0000E+00 1.5000E-01 19 1.333E+02 5.556E+00 0.0000E+00 2.0000E+01 0.0000E+00 1.5000E-01 20 1.667E+02 6.944E+00 0.0000E+00 2.5000E+01 0.0000E+00 1.5000E-01 21 2.000E+02 8.333E+00 0.0000E+00 3.0000E+01 0.0000E+00 1.5000E-01 22 2.333E+02 9.722E+00 0.0000E+00 3.5000E+01 0.0000E+00 1.5000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 3.333E-01 1.389E-02 0.0000E+00 1.0000E-01 0.0000E+00 3.0000E-01 25 8.333E-01 3.472E-02 0.0000E+00 2.5000E-01 0.0000E+00 3.0000E-01 26 1.667E+00 6.944E-02 0.0000E+00 5.0000E-01 0.0000E+00 3.0000E-01 27 3.333E+00 1.389E-01 0.0000E+00 1.0000E+00 0.0000E+00 3.0000E-01 28 5.000E+00 2.083E-01 0.0000E+00 1.5000E+00 0.0000E+00 3.0000E-01 29 6.667E+00 2.778E-01 0.0000E+00 2.0000E+00 0.0000E+00 3.0000E-01 30 1.000E+01 4.167E-01 0.0000E+00 3.0000E+00 0.0000E+00 3.0000E-01 31 1.333E+01 5.556E-01 0.0000E+00 4.0000E+00 0.0000E+00 3.0000E-01 32 1.667E+01 6.944E-01 0.0000E+00 5.0000E+00 0.0000E+00 3.0000E-01 33 2.000E+01 8.333E-01 0.0000E+00 6.0000E+00 0.0000E+00 3.0000E-01 34 2.333E+01 9.722E-01 0.0000E+00 7.0000E+00 0.0000E+00 3.0000E-01 35 2.667E+01 1.111E+00 0.0000E+00 8.0000E+00 0.0000E+00 3.0000E-01 36 3.000E+01 1.250E+00 0.0000E+00 9.0000E+00 0.0000E+00 3.0000E-01 37 3.333E+01 1.389E+00 0.0000E+00 1.0000E+01 0.0000E+00 3.0000E-01 38 4.167E+01 1.736E+00 0.0000E+00 1.2500E+01 0.0000E+00 3.0000E-01 39 5.000E+01 2.083E+00 0.0000E+00 1.5000E+01 0.0000E+00 3.0000E-01 40 5.833E+01 2.431E+00 0.0000E+00 1.7500E+01 0.0000E+00 3.0000E-01 41 6.667E+01 2.778E+00 0.0000E+00 2.0000E+01 0.0000E+00 3.0000E-01 42 8.333E+01 3.472E+00 0.0000E+00 2.5000E+01 0.0000E+00 3.0000E-01 43 1.000E+02 4.167E+00 0.0000E+00 3.0000E+01 0.0000E+00 3.0000E-01 44 1.167E+02 4.861E+00 0.0000E+00 3.5000E+01 0.0000E+00 3.0000E-01 45 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 46 1.667E-01 6.944E-03 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E-01 47 4.167E-01 1.736E-02 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E-01 48 8.333E-01 3.472E-02 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E-01 49 1.667E+00 6.944E-02 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E-01 50 2.500E+00 1.042E-01 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E-01 51 3.333E+00 1.389E-01 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E-01 52 5.000E+00 2.083E-01 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E-01 53 6.667E+00 2.778E-01 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E-01 54 8.333E+00 3.472E-01 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E-01 55 1.000E+01 4.167E-01 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E-01 56 1.167E+01 4.861E-01 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E-01 57 1.333E+01 5.556E-01 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E-01 58 1.500E+01 6.250E-01 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E-01 59 1.667E+01 6.944E-01 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E-01 60 2.083E+01 8.681E-01 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E-01 61 2.500E+01 1.042E+00 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E-01 62 2.917E+01 1.215E+00 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E-01 63 3.333E+01 1.389E+00 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E-01 64 4.167E+01 1.736E+00 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E-01 65 5.000E+01 2.083E+00 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E-01 66 5.833E+01 2.431E+00 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E-01 67 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 68 8.333E-02 3.472E-03 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+00 69 2.083E-01 8.681E-03 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+00 70 4.167E-01 1.736E-02 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+00 71 8.333E-01 3.472E-02 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+00 72 1.250E+00 5.208E-02 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+00 73 1.667E+00 6.944E-02 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+00 74 2.500E+00 1.042E-01 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+00 75 3.333E+00 1.389E-01 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+00 76 4.167E+00 1.736E-01 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+00 77 5.000E+00 2.083E-01 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+00 78 5.833E+00 2.431E-01 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+00 79 6.667E+00 2.778E-01 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+00 80 7.500E+00 3.125E-01 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+00 81 8.333E+00 3.472E-01 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+00 82 1.042E+01 4.340E-01 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+00 83 1.250E+01 5.208E-01 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+00 84 1.458E+01 6.076E-01 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+00 85 1.667E+01 6.944E-01 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+00 86 2.083E+01 8.681E-01 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+00 87 2.500E+01 1.042E+00 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+00 88 2.917E+01 1.215E+00 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+00 89 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 90 8.333E-03 3.472E-04 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+01 91 2.083E-02 8.681E-04 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+01 92 4.167E-02 1.736E-03 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+01 93 8.333E-02 3.472E-03 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+01 94 1.250E-01 5.208E-03 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+01 95 1.667E-01 6.944E-03 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+01 96 2.500E-01 1.042E-02 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+01 97 3.333E-01 1.389E-02 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+01 98 4.167E-01 1.736E-02 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+01 99 5.000E-01 2.083E-02 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+01 100 5.833E-01 2.431E-02 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+01 101 6.667E-01 2.778E-02 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+01 102 7.500E-01 3.125E-02 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+01 103 8.333E-01 3.472E-02 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+01 104 1.042E+00 4.340E-02 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+01 105 1.250E+00 5.208E-02 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+01 106 1.458E+00 6.076E-02 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+01 107 1.667E+00 6.944E-02 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+01 108 2.083E+00 8.681E-02 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+01 109 2.500E+00 1.042E-01 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+01 110 2.917E+00 1.215E-01 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+01 111 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 112 1.852E-03 7.716E-05 0.0000E+00 1.0000E-01 0.0000E+00 5.4000E+01 113 4.630E-03 1.929E-04 0.0000E+00 2.5000E-01 0.0000E+00 5.4000E+01 114 9.259E-03 3.858E-04 0.0000E+00 5.0000E-01 0.0000E+00 5.4000E+01 115 1.852E-02 7.716E-04 0.0000E+00 1.0000E+00 0.0000E+00 5.4000E+01 116 2.778E-02 1.157E-03 0.0000E+00 1.5000E+00 0.0000E+00 5.4000E+01 117 3.704E-02 1.543E-03 0.0000E+00 2.0000E+00 0.0000E+00 5.4000E+01 118 5.556E-02 2.315E-03 0.0000E+00 3.0000E+00 0.0000E+00 5.4000E+01 119 7.407E-02 3.086E-03 0.0000E+00 4.0000E+00 0.0000E+00 5.4000E+01 120 9.259E-02 3.858E-03 0.0000E+00 5.0000E+00 0.0000E+00 5.4000E+01 121 1.111E-01 4.630E-03 0.0000E+00 6.0000E+00 0.0000E+00 5.4000E+01 122 1.296E-01 5.401E-03 0.0000E+00 7.0000E+00 0.0000E+00 5.4000E+01 123 1.481E-01 6.173E-03 0.0000E+00 8.0000E+00 0.0000E+00 5.4000E+01 124 1.667E-01 6.944E-03 0.0000E+00 9.0000E+00 0.0000E+00 5.4000E+01 125 1.852E-01 7.716E-03 0.0000E+00 1.0000E+01 0.0000E+00 5.4000E+01 126 2.315E-01 9.645E-03 0.0000E+00 1.2500E+01 0.0000E+00 5.4000E+01 127 2.778E-01 1.157E-02 0.0000E+00 1.5000E+01 0.0000E+00 5.4000E+01 128 3.241E-01 1.350E-02 0.0000E+00 1.7500E+01 0.0000E+00 5.4000E+01 129 3.704E-01 1.543E-02 0.0000E+00 2.0000E+01 0.0000E+00 5.4000E+01 130 4.630E-01 1.929E-02 0.0000E+00 2.5000E+01 0.0000E+00 5.4000E+01 131 5.556E-01 2.315E-02 0.0000E+00 3.0000E+01 0.0000E+00 5.4000E+01 132 6.481E-01 2.701E-02 0.0000E+00 3.5000E+01 0.0000E+00 5.4000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 1.25000E-02 VC 2.00I 15-JUL-2003 02-AUG-2003 08:03:27 PM